ZA200204814B - Substituted phenyl-piperazine derivatives, their preparation and use. - Google Patents
Substituted phenyl-piperazine derivatives, their preparation and use.Info
- Publication number
- ZA200204814B ZA200204814B ZA200204814A ZA200204814A ZA200204814B ZA 200204814 B ZA200204814 B ZA 200204814B ZA 200204814 A ZA200204814 A ZA 200204814A ZA 200204814 A ZA200204814 A ZA 200204814A ZA 200204814 B ZA200204814 B ZA 200204814B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparation
- substituted phenyl
- piperazine derivatives
- piperazine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA199901885 | 1999-12-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200204814B true ZA200204814B (en) | 2003-08-27 |
Family
ID=8108803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200204814A ZA200204814B (en) | 1999-12-30 | 2002-06-14 | Substituted phenyl-piperazine derivatives, their preparation and use. |
Country Status (28)
Country | Link |
---|---|
US (1) | US6699864B2 (fr) |
EP (1) | EP1246816B1 (fr) |
JP (1) | JP2003519224A (fr) |
KR (1) | KR100790916B1 (fr) |
CN (1) | CN1230432C (fr) |
AR (1) | AR029428A1 (fr) |
AT (1) | ATE261959T1 (fr) |
AU (1) | AU2152101A (fr) |
BG (1) | BG65262B1 (fr) |
BR (1) | BR0016952A (fr) |
CA (1) | CA2395705C (fr) |
CZ (1) | CZ20022319A3 (fr) |
DE (1) | DE60009155T2 (fr) |
EA (1) | EA006071B1 (fr) |
ES (1) | ES2213634T3 (fr) |
HU (1) | HUP0203722A3 (fr) |
IL (2) | IL150241A0 (fr) |
IS (1) | IS2174B (fr) |
MX (1) | MXPA02006223A (fr) |
NO (1) | NO322666B1 (fr) |
NZ (1) | NZ519647A (fr) |
PL (1) | PL199351B1 (fr) |
PT (1) | PT1246816E (fr) |
SK (1) | SK9442002A3 (fr) |
TR (2) | TR200400645T4 (fr) |
UA (1) | UA72948C2 (fr) |
WO (1) | WO2001049678A1 (fr) |
ZA (1) | ZA200204814B (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
DE10259244A1 (de) * | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | N-(Indolethyl-)cycloamin-Verbindungen |
JP4667366B2 (ja) | 2003-04-04 | 2011-04-13 | ハー・ルンドベック・アクチエゼルスカベット | セロトニン再取り込み阻害剤としての4−(2−フェニルスルファニル−フェニル)−ピペリジン誘導体 |
UA81300C2 (en) * | 2003-04-04 | 2007-12-25 | Lundbeck & Co As H | Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture |
EP1701940B1 (fr) | 2003-12-23 | 2008-05-28 | H.Lundbeck A/S | Dérivés de 2-(1h-indolylsulfanyl)-benzyl amine comme ssri |
SE0400441D0 (sv) | 2004-02-25 | 2004-02-25 | Active Biotech Ab | Novel Benzofurans and Indols |
AR052308A1 (es) | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
AR054393A1 (es) | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
US7629473B2 (en) | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
EP2439201B1 (fr) | 2006-06-16 | 2013-08-07 | H. Lundbeck A/S | Composés avec activité combiné sert, 5-ht3 et 5-ht1a |
WO2009049030A1 (fr) * | 2007-10-09 | 2009-04-16 | Triton Biopharma, Llc | Procédé d'utilisation de compositions ayant une activité anxiolytique et antidépressive, ainsi que neurologique autre et compositions de matière |
CA2718138A1 (fr) * | 2008-03-14 | 2009-09-17 | Timo Heinrich | Composes d'azaindole pour le traitement de troubles du systeme nerveux central |
EP3495347A1 (fr) | 2013-04-04 | 2019-06-12 | LEK Pharmaceuticals d.d. | Nouveau procédé de synthèse de la 1-(2-((2,4-dimethylphenyl)thio)phenyl)pipérazine |
WO2015169180A1 (fr) * | 2014-05-04 | 2015-11-12 | Sunshine Lake Pharma Co., Ltd. | Composés pipéraziniques substitués, procédés et utilisation associés |
CN105085491B (zh) * | 2014-05-05 | 2019-06-25 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
CN106243088B (zh) | 2015-06-03 | 2019-01-04 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
WO2017012579A1 (fr) * | 2015-07-23 | 2017-01-26 | 广东东阳光药业有限公司 | Composés d'indole substitués, méthodes d'utilisation et utilisations de ceux-ci |
JP7282082B2 (ja) * | 2017-09-29 | 2023-05-26 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | 置換ピリミジンピペラジン化合物及びその使用 |
CN111518012A (zh) * | 2020-05-27 | 2020-08-11 | 中国药科大学 | 含苯硫醚结构的化合物或其药学上可接受的盐、制备方法和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2138865A1 (de) * | 1970-08-15 | 1973-02-22 | Sumitomo Chemical Co | 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel |
GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
US5814644A (en) * | 1993-04-15 | 1998-09-29 | Merck Sharp & Dohme, Ltd. | Indole derivatives as dopamine D4 antagonists |
FR2712591B1 (fr) * | 1993-11-19 | 1996-02-09 | Pf Medicament | Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique. |
WO1997019039A1 (fr) | 1995-11-17 | 1997-05-29 | Novartis Ag | Synthese en phase solide de composes heterocycliques et d'une banque combinatoire de composes |
USH2007H1 (en) * | 1996-01-19 | 2001-12-04 | Fmc Corporation | Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines |
ES2128266B1 (es) * | 1997-07-08 | 2000-01-16 | Vita Invest Sa | Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes. |
ATE360818T1 (de) | 1999-06-15 | 2007-05-15 | Aventis Pharma Inc | Festphasensynthese von n,n-disubstituierten diazacycloalkylcarboxy-derivaten |
JP2003519227A (ja) * | 1999-12-30 | 2003-06-17 | ハー・ルンドベック・アクチエゼルスカベット | 置換されたベンゼン誘導体の製造方法 |
-
2000
- 2000-12-20 CZ CZ20022319A patent/CZ20022319A3/cs unknown
- 2000-12-20 HU HU0203722A patent/HUP0203722A3/hu unknown
- 2000-12-20 JP JP2001550218A patent/JP2003519224A/ja active Pending
- 2000-12-20 NZ NZ519647A patent/NZ519647A/en unknown
- 2000-12-20 WO PCT/DK2000/000721 patent/WO2001049678A1/fr active IP Right Grant
- 2000-12-20 BR BR0016952-8A patent/BR0016952A/pt not_active Application Discontinuation
- 2000-12-20 DE DE60009155T patent/DE60009155T2/de not_active Expired - Fee Related
- 2000-12-20 TR TR2004/00645T patent/TR200400645T4/xx unknown
- 2000-12-20 EA EA200200732A patent/EA006071B1/ru not_active IP Right Cessation
- 2000-12-20 CN CNB008192057A patent/CN1230432C/zh not_active Expired - Fee Related
- 2000-12-20 PT PT00984924T patent/PT1246816E/pt unknown
- 2000-12-20 ES ES00984924T patent/ES2213634T3/es not_active Expired - Lifetime
- 2000-12-20 AU AU21521/01A patent/AU2152101A/en not_active Abandoned
- 2000-12-20 EP EP00984924A patent/EP1246816B1/fr not_active Expired - Lifetime
- 2000-12-20 MX MXPA02006223A patent/MXPA02006223A/es active IP Right Grant
- 2000-12-20 TR TR2002/01683T patent/TR200201683T2/xx unknown
- 2000-12-20 IL IL15024100A patent/IL150241A0/xx unknown
- 2000-12-20 UA UA2002065260A patent/UA72948C2/uk unknown
- 2000-12-20 AT AT00984924T patent/ATE261959T1/de not_active IP Right Cessation
- 2000-12-20 PL PL355539A patent/PL199351B1/pl not_active IP Right Cessation
- 2000-12-20 CA CA002395705A patent/CA2395705C/fr not_active Expired - Fee Related
- 2000-12-20 SK SK944-2002A patent/SK9442002A3/sk unknown
- 2000-12-20 KR KR1020027008608A patent/KR100790916B1/ko not_active IP Right Cessation
- 2000-12-28 AR ARP000106987A patent/AR029428A1/es unknown
-
2002
- 2002-06-13 IS IS6420A patent/IS2174B/is unknown
- 2002-06-14 ZA ZA200204814A patent/ZA200204814B/xx unknown
- 2002-06-16 IL IL150241A patent/IL150241A/en not_active IP Right Cessation
- 2002-06-20 US US10/177,261 patent/US6699864B2/en not_active Expired - Fee Related
- 2002-06-28 NO NO20023146A patent/NO322666B1/no not_active IP Right Cessation
- 2002-07-17 BG BG106930A patent/BG65262B1/bg unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA200107983B (en) | New compounds, their preparation and use. | |
HK1048999A1 (zh) | 氮雜䓬吲衍生物,它們的製備和應用 | |
HK1047743A1 (en) | New use and novel n-azabicyclo-amide derivatives. | |
ZA200104196B (en) | Azepinoindole derivatives, the production and use thereof. | |
ZA200007638B (en) | Pyrazoline derivatives, their preparation and application as medicaments. | |
ZA200201806B (en) | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof. | |
AU3958100A (en) | New compounds, their preparation and use | |
AU3958200A (en) | New compounds, their preparation and use | |
HUP0105414A3 (en) | Pyrrolo-isoquinoline, azepino- and diazepino-indole derivatives, their use and pharmaceutical compisitions containing them | |
AU3957900A (en) | New compounds, their preparation and use | |
ZA200204814B (en) | Substituted phenyl-piperazine derivatives, their preparation and use. | |
ZA200001746B (en) | 3-amino-3-arylpropan-1-ol derivatives, and their preparation and use. | |
HUP0105039A3 (en) | Fungicidal propargylether derivatives, preparation and use thereof | |
ZA200003706B (en) | Cyclobutene derivatives, their preparation and their therapeutic uses. | |
ZA996814B (en) | Aluminosilicate compositions, preparation and use. | |
ZA200001490B (en) | (Poly)thiaalkynoic compounds and their derivatives, compositions comprising them and their use. | |
HK1049655A1 (en) | Substituted norbornylamino derivatives, productionand use thereof and medicaments containing them. | |
ZA989664B (en) | 3-substituted tetrahydropyrimidinone derivatives, their preparation and use. | |
HUP0201810A3 (en) | Sootepenseone and its derivatives, their preparation and use as medicament | |
ZA200001747B (en) | 3-Amino-3-arylpropan-1-ol derivatives, their preparation and use. | |
ZA200109571B (en) | Novel compounds, their use and preparation. | |
PL362573A1 (en) | Imidazolidine derivatives, their preparation, and their use as antinflamatory agent. | |
HUP0203678A3 (en) | Nitro-sulfobenzamide-derivatives, preparation and use thereof | |
HK1058518A1 (en) | Substituted phenyl-piperazine derivatives, their preparation and use | |
SI1246816T1 (en) | Substituted phenyl-piperazine derivatives, their preparation and use |