ZA200203697B - A method of microencapsulation. - Google Patents
A method of microencapsulation. Download PDFInfo
- Publication number
- ZA200203697B ZA200203697B ZA200203697A ZA200203697A ZA200203697B ZA 200203697 B ZA200203697 B ZA 200203697B ZA 200203697 A ZA200203697 A ZA 200203697A ZA 200203697 A ZA200203697 A ZA 200203697A ZA 200203697 B ZA200203697 B ZA 200203697B
- Authority
- ZA
- South Africa
- Prior art keywords
- microcapsules
- anyone
- oil
- substance
- water
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 49
- 239000003094 microcapsule Substances 0.000 claims description 86
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 72
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 44
- 239000000126 substance Substances 0.000 claims description 32
- 239000003960 organic solvent Substances 0.000 claims description 30
- 239000000463 material Substances 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 23
- 239000000243 solution Substances 0.000 claims description 21
- 229940088594 vitamin Drugs 0.000 claims description 20
- 229930003231 vitamin Natural products 0.000 claims description 20
- 239000011782 vitamin Substances 0.000 claims description 20
- 235000013343 vitamin Nutrition 0.000 claims description 19
- -1 poly(alkyl) Polymers 0.000 claims description 15
- 239000003921 oil Substances 0.000 claims description 13
- 239000000839 emulsion Substances 0.000 claims description 12
- 229920006395 saturated elastomer Polymers 0.000 claims description 12
- 239000006185 dispersion Substances 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 229920000642 polymer Polymers 0.000 claims description 8
- 235000019165 vitamin E Nutrition 0.000 claims description 8
- 239000011709 vitamin E Substances 0.000 claims description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 235000015872 dietary supplement Nutrition 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 5
- 229920003134 Eudragit® polymer Polymers 0.000 claims description 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 239000000049 pigment Substances 0.000 claims description 4
- 235000019154 vitamin C Nutrition 0.000 claims description 4
- 239000011718 vitamin C Substances 0.000 claims description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 3
- 229930003268 Vitamin C Natural products 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000008406 cosmetic ingredient Substances 0.000 claims description 2
- 239000006052 feed supplement Substances 0.000 claims description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims 10
- 235000019156 vitamin B Nutrition 0.000 claims 2
- 239000011720 vitamin B Substances 0.000 claims 2
- 235000019168 vitamin K Nutrition 0.000 claims 2
- 239000011712 vitamin K Substances 0.000 claims 2
- 229930003270 Vitamin B Natural products 0.000 claims 1
- 229930003448 Vitamin K Natural products 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 239000002417 nutraceutical Substances 0.000 claims 1
- 235000021436 nutraceutical agent Nutrition 0.000 claims 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 description 36
- 239000012074 organic phase Substances 0.000 description 19
- 239000008346 aqueous phase Substances 0.000 description 18
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 13
- 239000013505 freshwater Substances 0.000 description 10
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 8
- 238000005538 encapsulation Methods 0.000 description 8
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 6
- 238000013019 agitation Methods 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 229930003427 Vitamin E Natural products 0.000 description 5
- 239000001058 brown pigment Substances 0.000 description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- 229940046009 vitamin E Drugs 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 239000011162 core material Substances 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000004062 sedimentation Methods 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 239000004408 titanium dioxide Substances 0.000 description 4
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 3
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000013270 controlled release Methods 0.000 description 3
- 230000002500 effect on skin Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 229940108325 retinyl palmitate Drugs 0.000 description 3
- 235000019172 retinyl palmitate Nutrition 0.000 description 3
- 239000011769 retinyl palmitate Substances 0.000 description 3
- 239000012798 spherical particle Substances 0.000 description 3
- 229930003799 tocopherol Natural products 0.000 description 3
- 235000010384 tocopherol Nutrition 0.000 description 3
- 229960001295 tocopherol Drugs 0.000 description 3
- 239000011732 tocopherol Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000004141 Sodium laurylsulphate Substances 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000011859 microparticle Substances 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 238000005191 phase separation Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- TVACALAUIQMRDF-UHFFFAOYSA-N dodecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCOP(O)(O)=O TVACALAUIQMRDF-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000021474 generally recognized As safe (food) Nutrition 0.000 description 1
- 235000021472 generally recognized as safe Nutrition 0.000 description 1
- 235000021473 generally recognized as safe (food ingredients) Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical group O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001490 poly(butyl methacrylate) polymer Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003244 pro-oxidative effect Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
- Y10T428/2987—Addition polymer from unsaturated monomers only
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Obesity (AREA)
- Cosmetics (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9927202A GB2356386A (en) | 1999-11-17 | 1999-11-17 | Microencapsulation |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200203697B true ZA200203697B (en) | 2003-05-09 |
Family
ID=10864684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200203697A ZA200203697B (en) | 1999-11-17 | 2002-05-09 | A method of microencapsulation. |
Country Status (13)
Country | Link |
---|---|
US (1) | US6932984B1 (fr) |
EP (2) | EP1231904A2 (fr) |
JP (1) | JP5175415B2 (fr) |
KR (1) | KR100717581B1 (fr) |
CN (1) | CN1391467A (fr) |
AU (1) | AU774354B2 (fr) |
CA (1) | CA2389688C (fr) |
GB (1) | GB2356386A (fr) |
HK (1) | HK1052304A1 (fr) |
IL (1) | IL149637A0 (fr) |
MX (1) | MXPA02004919A (fr) |
WO (1) | WO2001035933A2 (fr) |
ZA (1) | ZA200203697B (fr) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7838037B2 (en) * | 1999-11-17 | 2010-11-23 | Tagra Biotechnologies Ltd. | Method of microencapsulation |
KR100489318B1 (ko) * | 2001-08-25 | 2005-05-17 | 이원목 | 비타민 마이크로캡슐을 포함하는 섬유 유연제 조성물 |
KR100829719B1 (ko) * | 2001-12-20 | 2008-05-15 | 주식회사 코리아나화장품 | 주름개선 활성물질을 함유하는 분말형 화장료 조성물 |
JP4630597B2 (ja) * | 2003-08-04 | 2011-02-09 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 環境ホルモン排泄促進剤 |
US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
KR101051557B1 (ko) * | 2004-12-23 | 2011-07-22 | (주)아모레퍼시픽 | 비타민 k1을 포집시킨 고분자 마이크로캡슐의 제조 방법및 이를 함유하는 화장료 조성물 |
KR100799991B1 (ko) * | 2006-06-29 | 2008-01-31 | (주)에이티 랩 | 주름개선용 기능성 화장료 조성물 |
FR2906457B1 (fr) * | 2006-10-03 | 2008-11-28 | Oreal | Composition a effet bonne mine. |
FR2917966B1 (fr) * | 2007-06-29 | 2009-10-02 | Oreal | Produit cosmetique de soin des matieres keratiniques |
US8206731B2 (en) | 2007-12-12 | 2012-06-26 | Conopco, Inc. | Self-tanning effects |
US20090162306A1 (en) * | 2007-12-21 | 2009-06-25 | Conopco, Inc., D/B/A Unilever | Topical composition comprising coloring antioxidants |
WO2009138978A2 (fr) * | 2008-05-12 | 2009-11-19 | Tagra Biotechnologies Ltd | Compositions pour application topique comprenant des colorants microencapsulés |
US20090317341A1 (en) * | 2008-06-18 | 2009-12-24 | Conopco, Inc., D/B/A Unilever | Compositions for Lightening Skin Color |
FR2940023B1 (fr) | 2008-12-18 | 2011-03-18 | Oreal | Procede de maquillage et dispositif pour la mise en oeuvre d'un tel procede, comportant un applicateur vibrant |
US20100196577A1 (en) * | 2009-02-03 | 2010-08-05 | Tropicana Products, Inc. | Microencapsulated citrus phytochemicals comprising citrus limonoids and application to sports drinks |
US20100196554A1 (en) * | 2009-02-03 | 2010-08-05 | Tropicana Products, Inc. | Microencapsulated citrus phytochemicals comprising citrus limonoids and application to beverages |
US20100196549A1 (en) * | 2009-02-03 | 2010-08-05 | Tropicana Products, Inc. | Microencapsulated citrus phytochemicals and application to sports drinks |
US9545117B2 (en) * | 2009-02-03 | 2017-01-17 | Tropicana Products, Inc. | Microencapsulated citrus phytochemicals and application to beverages |
CN101513394B (zh) * | 2009-03-30 | 2011-04-27 | 浙江新和成股份有限公司 | 连续化纳米分散维生素a微胶囊的制备方法 |
US20110274763A1 (en) * | 2009-05-19 | 2011-11-10 | Nyden Bo Magnus | Slow releasing microcapsules and microspheres containing an active substance |
KR100978583B1 (ko) * | 2009-09-02 | 2010-08-27 | (주)바이오제닉스 | 화장품용 색조캡슐 조성물, 이의 제조방법 및 이를 이용한 화장품 제제 |
WO2011042902A2 (fr) | 2009-10-07 | 2011-04-14 | Tagra Biotechnologies Ltd | Microcapsules comprenant du peroxyde de benzoyle et compositions topiques comprenant celles-ci |
US9205395B2 (en) * | 2009-10-15 | 2015-12-08 | Encapsys, Llc | Encapsulation |
CN103764271A (zh) | 2011-05-16 | 2014-04-30 | 塔格拉生物科技有限公司 | 包含黑色颜料的微囊 |
CN102198117B (zh) * | 2011-06-17 | 2013-02-27 | 中国林业科学研究院林产化学工业研究所 | 一种温敏性高分子微胶囊及其制备方法和应用 |
EP2550863A1 (fr) | 2011-07-27 | 2013-01-30 | Bayer Intellectual Property GmbH | Particules contenant une matière active à base de polyacrylate |
WO2013040149A1 (fr) | 2011-09-16 | 2013-03-21 | Revlon Consumer Products | Microcapsules et procédés de production de microcapsules |
WO2013093890A2 (fr) | 2011-12-23 | 2013-06-27 | L'oreal | Procédé de maquillage de la peau |
CN104168870B (zh) * | 2012-01-17 | 2017-04-19 | 欧莱雅 | 凝胶形式的变色组合物 |
WO2013106998A1 (fr) | 2012-01-17 | 2013-07-25 | L'oreal | Composition de modification de couleur sous forme d'une émulsion h/e |
ES2635015T3 (es) | 2012-01-17 | 2017-10-02 | L'oreal | Composición cosmética que comprende pigmentos encapsulados y partículas reflectantes predispersas en un aceite |
WO2013106996A1 (fr) | 2012-01-17 | 2013-07-25 | L'oreal | Composition de changement de couleur sous forme de gel |
WO2013107000A1 (fr) | 2012-01-17 | 2013-07-25 | L'oreal | Composition à changement de couleur |
KR101362479B1 (ko) * | 2012-02-15 | 2014-02-12 | 주식회사 나노브릭 | 캡슐 및 그 제조 방법 |
WO2014074797A1 (fr) | 2012-11-09 | 2014-05-15 | Civitas Therapeutics, Inc. | Poudres pulmonaires de densité ultra basse |
US8545878B1 (en) * | 2012-11-09 | 2013-10-01 | Civitas Therapeutics, Inc. | Capsules containing high doses of levodopa for pulmonary use |
KR101471447B1 (ko) * | 2012-11-30 | 2014-12-10 | (주)케이피티 | 코어씨드 및 감압-파괴성 벽층을 갖는 색상-변화 마이크로캡슐 및 이의 제조방법 |
WO2014082299A1 (fr) * | 2012-11-30 | 2014-06-05 | L'oreal | Composition de changement de couleur |
KR101456835B1 (ko) | 2012-11-30 | 2014-11-03 | (주)케이피티 | 색소코어 및 감압-파괴성 벽층을 갖는 색상-변화 마이크로캡슐 및 이의 제조방법 |
CN103125946A (zh) * | 2013-02-28 | 2013-06-05 | 河北科技大学 | 一种叶黄素纳米颗粒及其制备方法 |
EP2961370B1 (fr) | 2013-02-28 | 2020-12-23 | Tagra Biotechnologies Ltd | Microcapsules comprenant des agents de protection solaire |
EP2774597A1 (fr) | 2013-03-06 | 2014-09-10 | L'Oréal | Composition changeant de couleur sous forme d'émulsion comprenant un homopolymère ou copolymère acrylique réticulé partiellement neutralisé |
EP2774603A1 (fr) | 2013-03-06 | 2014-09-10 | L'Oréal | Composition à couleur changeante, sous forme d'émulsion contenant un agent gélifiant émulsifiant hydrophile |
DE102013204110A1 (de) | 2013-03-11 | 2014-09-25 | Beiersdorf Ag | Wirkstoffkombinationen aus Alkylamidothiazolen und einem oder mehreren Cyclodextrinen |
ES2754037T3 (es) | 2013-07-12 | 2020-04-15 | Oreal | Composición que cambia de color en forma de emulsión de aceite en agua que comprende un tensioactivo geminal |
EP2823804B1 (fr) | 2013-07-12 | 2019-08-21 | L'Oréal | Composition changeant de couleur comprenant des pigments et une grande quantité d'eau |
EP2823803B8 (fr) * | 2013-07-12 | 2020-02-26 | L'Oréal | Composition changeant de couleur en émulsion O/W sous forme d'oléosomes |
WO2015051054A2 (fr) * | 2013-10-04 | 2015-04-09 | The Procter & Gamble Company | Particule de distribution contenant un agent bénéfique |
PL3113761T3 (pl) | 2014-03-04 | 2020-11-16 | Tagra Biotechnologies Ltd | Mikrokapsułki zawierające składnik aktywny |
CN113876599A (zh) | 2014-03-04 | 2022-01-04 | 塔格拉生物技术有限公司 | 含着色剂的微胶囊 |
EP2939655A1 (fr) | 2014-04-30 | 2015-11-04 | L'Oréal | Composition comprenant des microcapsules contenant des particules réfléchissantes |
EP2939653A1 (fr) | 2014-04-30 | 2015-11-04 | L'Oréal | Composition comprenant des microcapsules contenant des particules avec un point élevé à l'état humide |
EP2939654A1 (fr) | 2014-04-30 | 2015-11-04 | L'Oréal | Composition comprenant des microcapsules contenant un élastomère de silicone |
US9186305B1 (en) * | 2014-05-19 | 2015-11-17 | Shiseido Company, Ltd. | Sunscreen products in which excessive whiteness due to titanium dioxide and zinc oxide is visually masked upon skin application |
CN104226191B (zh) * | 2014-09-01 | 2017-04-19 | 南京理工大学 | 乙基纤维素多孔颗粒的常温制备方法 |
CN107530233A (zh) * | 2015-04-30 | 2018-01-02 | Kpt有限公司 | 用于化妆品原料的组合物和用于制备该组合物的方法 |
WO2017036542A1 (fr) * | 2015-09-03 | 2017-03-09 | L'oreal | Composition anhydre de soin et/ou de maquillage de matières kératiniques comprenant des microcapsules encapsulant une dispersion huileuse d'au moins un agent réfléchissant |
US10568818B2 (en) | 2015-09-03 | 2020-02-25 | L'oreal | Oil-in-water emulsion for caring for and/or making up keratin materials comprising microcapsules encapsulating an oily dispersion of at least one reflective agent |
JP6676149B2 (ja) * | 2015-09-03 | 2020-04-08 | ロレアル | 少なくとも1つの反射剤の油性分散体を封入するマイクロカプセルを含む、ケラチン物質をケアし、および/またはメイクアップするための油中水型エマルジョン |
JP6937293B2 (ja) | 2015-09-03 | 2021-09-22 | タグラ バイオテクノロジーズ リミテッド | 反射剤を封入したマイクロカプセル |
WO2017036538A1 (fr) * | 2015-09-03 | 2017-03-09 | L'oreal | Composition aqueuse pour le soin et/ou le maquillage de matières kératiniques qui comprend des microcapsules encapsulant une dispersion huileuse contenant au moins un agent réfléchissant |
WO2017036540A1 (fr) * | 2015-09-03 | 2017-03-09 | L'oreal | Gel aqueux pour le soin et/ou le maquillage de matières kératiniques comprenant des microcapsules encapsulant une dispersion huileuse d'au moins un agent réfléchissant |
WO2017036541A1 (fr) * | 2015-09-03 | 2017-03-09 | L'oreal | Poudre libre ou pressée pour le soin et/ou le maquillage de matières kératiniques comprenant des microcapsules encapsulant une dispersion huileuse d'au moins un agent réfléchissant |
CN105343723B (zh) * | 2015-12-15 | 2019-05-07 | 广西大海阳光药业有限公司 | 一种桔远止咳微囊的制备方法 |
WO2017179041A1 (fr) * | 2016-04-11 | 2017-10-19 | Tagra Biotechnologies Ltd. | Microcapsules encapsulant des matériaux de silicone |
BR102017010071A2 (pt) * | 2017-05-12 | 2018-12-04 | Natura Cosméticos S.A. | composição cosmética corporal, hidratante corporal, uso e método cosmético para homogeneização da tonalidade da pele |
CN107982095B (zh) * | 2017-10-19 | 2020-03-27 | 珀莱雅化妆品股份有限公司 | 一种具有抗皱功效的缓释固体微球的制备方法 |
CN108553336A (zh) * | 2018-04-11 | 2018-09-21 | 广州凯普秀科技有限公司 | 一种漱口珠及其制备方法和应用 |
FR3090325B1 (fr) | 2018-12-21 | 2021-01-01 | Oreal | Composition du type gel/gel comprenant des particules de nitrure de bore et au moins un pigment encapsule |
CN113091987B (zh) * | 2021-03-29 | 2022-02-22 | 山东大学 | 柔性微胶囊驻极体传感器及其制备方法 |
FR3122088B1 (fr) | 2021-04-21 | 2024-06-14 | Oreal | Composition changeant de couleur sous forme de gel aqueux |
CN113546586A (zh) * | 2021-07-22 | 2021-10-26 | 苏州来奇祥生物科技有限公司 | 一种利用三元共聚催化剂制备温控微胶囊的工艺方法 |
CN113925843B (zh) * | 2021-11-25 | 2023-10-10 | 华中药业股份有限公司 | 一种卡托普利缓释微胶囊及其制备方法 |
CN114984872A (zh) * | 2022-06-08 | 2022-09-02 | 顺德职业技术学院 | 维生素a微胶囊及其制备方法 |
KR102470009B1 (ko) * | 2022-06-10 | 2022-11-23 | 주식회사 엘지생활건강 | 자외선 차단 효율 상승효과를 갖는 유기 자외선 차단제 캡슐 |
CN115813800B (zh) * | 2022-12-20 | 2024-02-13 | 深圳市仙迪化妆品股份有限公司 | 一种化妆品用视黄醇类复合微粉及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2010115A1 (de) * | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
JPS523342B2 (fr) | 1972-01-26 | 1977-01-27 | ||
JPS5438164B2 (fr) * | 1972-05-29 | 1979-11-19 | ||
US4384975A (en) | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
FR2766368B1 (fr) * | 1997-07-24 | 2000-03-31 | Univ Claude Bernard Lyon | Procede de preparation de nanocapsules de type vesiculaire, utilisables notamment comme vecteurs colloidaux de principes actifs pharmaceutiques ou autres |
-
1999
- 1999-11-17 GB GB9927202A patent/GB2356386A/en not_active Withdrawn
-
2000
- 2000-11-16 AU AU12986/01A patent/AU774354B2/en not_active Expired
- 2000-11-16 MX MXPA02004919A patent/MXPA02004919A/es active IP Right Grant
- 2000-11-16 WO PCT/IL2000/000759 patent/WO2001035933A2/fr active IP Right Grant
- 2000-11-16 EP EP00974775A patent/EP1231904A2/fr not_active Withdrawn
- 2000-11-16 JP JP2001537926A patent/JP5175415B2/ja not_active Expired - Lifetime
- 2000-11-16 IL IL14963700A patent/IL149637A0/xx active IP Right Grant
- 2000-11-16 CA CA2389688A patent/CA2389688C/fr not_active Expired - Lifetime
- 2000-11-16 KR KR1020027006154A patent/KR100717581B1/ko active IP Right Grant
- 2000-11-16 EP EP08017575A patent/EP2047844A3/fr not_active Ceased
- 2000-11-16 CN CN00815870A patent/CN1391467A/zh active Pending
- 2000-11-16 US US10/130,529 patent/US6932984B1/en not_active Expired - Lifetime
-
2002
- 2002-05-09 ZA ZA200203697A patent/ZA200203697B/en unknown
-
2003
- 2003-06-30 HK HK03104652.8A patent/HK1052304A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2001035933A3 (fr) | 2001-10-18 |
MXPA02004919A (es) | 2003-10-14 |
JP5175415B2 (ja) | 2013-04-03 |
US6932984B1 (en) | 2005-08-23 |
HK1052304A1 (zh) | 2003-09-11 |
EP2047844A3 (fr) | 2010-02-10 |
CN1391467A (zh) | 2003-01-15 |
CA2389688C (fr) | 2010-02-09 |
KR20020070279A (ko) | 2002-09-05 |
CA2389688A1 (fr) | 2001-05-25 |
IL149637A0 (en) | 2002-11-10 |
GB9927202D0 (en) | 2000-01-12 |
KR100717581B1 (ko) | 2007-05-15 |
AU1298601A (en) | 2001-05-30 |
EP2047844A2 (fr) | 2009-04-15 |
AU774354B2 (en) | 2004-06-24 |
EP1231904A2 (fr) | 2002-08-21 |
GB2356386A (en) | 2001-05-23 |
JP2003514008A (ja) | 2003-04-15 |
WO2001035933A2 (fr) | 2001-05-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU774354B2 (en) | A method of microencapsulation | |
EP1928594B1 (fr) | Procede permettant de produire des microcapsules a plusieurs couches | |
RU2606854C1 (ru) | Способ получения нанокапсул сухого экстракта шпината | |
JP4982178B2 (ja) | マイクロカプセル封入系およびその適用 | |
RU2555824C1 (ru) | Способ получения микрокапсул сухого экстракта топинамбура в пектине | |
Rabišková et al. | The influence of HLB on the encapsulation of oils by complex coacervation | |
RU2500404C2 (ru) | Способ получения микрокапсул лекарственных препаратов группы цефалоспоринов в интерфероне | |
IL149637A (en) | Method of microencapsulation | |
CN108042511A (zh) | 含紫草素的微胶囊及制备方法和用途 | |
CN100528956C (zh) | 包裹水溶性活性成分的纳米粒子及其制备方法 | |
RU2634256C2 (ru) | Способ получения нанокапсул сухого экстракта топинамбура | |
CN101411674A (zh) | 包含在微囊中的活性成分的化妆制剂 | |
WO2001064331A1 (fr) | Procede de production de microcapsules et/ou de nanocapsules | |
RU2555466C2 (ru) | Способ биоинкапсуляции | |
RU2555055C1 (ru) | Способ получения нанокапсул сульфата глюкозамина в ксантановой камеди | |
RU2557975C1 (ru) | Способ получения нанокапсул сульфата глюкозамина в каррагинане | |
RU2555472C2 (ru) | Способ получения микрокапсул антиоксидантов в пектине | |
RU2538678C2 (ru) | Способ биоинкапсуляции | |
RU2549959C2 (ru) | Способ биоинкапсуляции | |
IL189633A (en) | Method for production of double-layer and triple-layer microcapsules | |
RU2538646C1 (ru) | Способ биоинкапсуляции |