ZA200203394B - Pharmaceutical compositions. - Google Patents
Pharmaceutical compositions. Download PDFInfo
- Publication number
- ZA200203394B ZA200203394B ZA200203394A ZA200203394A ZA200203394B ZA 200203394 B ZA200203394 B ZA 200203394B ZA 200203394 A ZA200203394 A ZA 200203394A ZA 200203394 A ZA200203394 A ZA 200203394A ZA 200203394 B ZA200203394 B ZA 200203394B
- Authority
- ZA
- South Africa
- Prior art keywords
- oxcarbazepine
- dosage form
- oral dosage
- patient
- food
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title description 2
- CTRLABGOLIVAIY-UHFFFAOYSA-N oxcarbazepine Chemical compound C1C(=O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 CTRLABGOLIVAIY-UHFFFAOYSA-N 0.000 claims description 79
- 229960001816 oxcarbazepine Drugs 0.000 claims description 73
- 239000006186 oral dosage form Substances 0.000 claims description 54
- 230000009246 food effect Effects 0.000 claims description 17
- 235000021471 food effect Nutrition 0.000 claims description 16
- 238000004090 dissolution Methods 0.000 claims description 12
- 235000013305 food Nutrition 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 11
- 238000000338 in vitro Methods 0.000 claims description 10
- 239000002552 dosage form Substances 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 7
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 description 31
- 238000000576 coating method Methods 0.000 description 20
- 239000000546 pharmaceutical excipient Substances 0.000 description 19
- 239000011248 coating agent Substances 0.000 description 17
- 239000000203 mixture Substances 0.000 description 17
- 238000009472 formulation Methods 0.000 description 12
- 239000008187 granular material Substances 0.000 description 12
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 11
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- 239000008186 active pharmaceutical agent Substances 0.000 description 7
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- 229940088679 drug related substance Drugs 0.000 description 7
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
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- 229950005425 sodium myristyl sulfate Drugs 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
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- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
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- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- MYOWBHNETUSQPA-UHFFFAOYSA-N tetradecane-1-sulfonic acid Chemical compound CCCCCCCCCCCCCCS(O)(=O)=O MYOWBHNETUSQPA-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
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- 229940116362 tragacanth Drugs 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
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- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB9925962.4A GB9925962D0 (en) | 1999-11-02 | 1999-11-02 | Organic compounds |
Publications (1)
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| ZA200203394A ZA200203394B (en) | 1999-11-02 | 2002-04-29 | Pharmaceutical compositions. |
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| JP (3) | JP2003514780A (no) |
| KR (1) | KR100493836B1 (no) |
| CN (1) | CN1407894A (no) |
| AT (1) | ATE401892T1 (no) |
| AU (1) | AU777705B2 (no) |
| BR (1) | BR0015188A (no) |
| CA (1) | CA2388609C (no) |
| CZ (1) | CZ302847B6 (no) |
| DE (1) | DE60039629D1 (no) |
| ES (1) | ES2311001T3 (no) |
| GB (1) | GB9925962D0 (no) |
| HK (1) | HK1050839B (no) |
| HU (1) | HU227685B1 (no) |
| IL (3) | IL149147A0 (no) |
| MX (1) | MXPA02004389A (no) |
| NO (1) | NO330947B1 (no) |
| NZ (1) | NZ518378A (no) |
| PL (1) | PL200273B1 (no) |
| RU (1) | RU2330666C2 (no) |
| SK (1) | SK287479B6 (no) |
| TR (1) | TR200200951T2 (no) |
| WO (1) | WO2001032183A2 (no) |
| ZA (1) | ZA200203394B (no) |
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| US20020022056A1 (en) | 1997-02-14 | 2002-02-21 | Burkhard Schlutermann | Oxacarbazepine film-coated tablets |
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| GB0221956D0 (en) * | 2002-09-20 | 2002-10-30 | Novartis Ag | Organic compounds |
| KR20060118426A (ko) * | 2003-09-03 | 2006-11-23 | 노파르티스 아게 | 당뇨병성 신경병증성 통증 치료 및 수면 개선을 위한옥스카르바제핀의 용도 |
| AR048672A1 (es) * | 2004-03-22 | 2006-05-17 | Novartis Ag | Tabletas de desintegracion que comprenden licarbazepina |
| US20090196919A1 (en) * | 2004-10-25 | 2009-08-06 | Ajay Singla | Oxcarbazepine dosage forms |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
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|---|---|---|---|---|
| CH649080A5 (de) * | 1981-04-16 | 1985-04-30 | Ciba Geigy Ag | 5h-dibenz(b,f)azepin-5-carboxamide als mittel zur prophylaxe und behandlung von zerebraler leistungsinsuffizienz. |
| FR2699077B1 (fr) * | 1992-12-16 | 1995-01-13 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes. |
| FR2702148B1 (fr) * | 1993-03-05 | 1995-04-07 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement du neuro-sida. |
| US5472714A (en) * | 1993-09-08 | 1995-12-05 | Ciba-Geigy Corporation | Double-layered oxcarbazepine tablets |
| ZA953078B (en) * | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
| US20020022056A1 (en) * | 1997-02-14 | 2002-02-21 | Burkhard Schlutermann | Oxacarbazepine film-coated tablets |
| CO4920215A1 (es) * | 1997-02-14 | 2000-05-29 | Novartis Ag | Tabletas de oxacarbazepina recubiertas de una pelicula y metodo para la produccion de estas formulaciones |
-
1999
- 1999-11-02 GB GBGB9925962.4A patent/GB9925962D0/en not_active Ceased
-
2000
- 2000-10-31 BR BR0015188-2A patent/BR0015188A/pt not_active IP Right Cessation
- 2000-10-31 CZ CZ20021529A patent/CZ302847B6/cs not_active IP Right Cessation
- 2000-10-31 AT AT00983101T patent/ATE401892T1/de active
- 2000-10-31 MX MXPA02004389A patent/MXPA02004389A/es unknown
- 2000-10-31 RU RU2002113752/15A patent/RU2330666C2/ru not_active IP Right Cessation
- 2000-10-31 ES ES00983101T patent/ES2311001T3/es not_active Expired - Lifetime
- 2000-10-31 AU AU19978/01A patent/AU777705B2/en not_active Ceased
- 2000-10-31 DE DE60039629T patent/DE60039629D1/de not_active Expired - Lifetime
- 2000-10-31 NZ NZ518378A patent/NZ518378A/en not_active IP Right Cessation
- 2000-10-31 HU HU0203556A patent/HU227685B1/hu not_active IP Right Cessation
- 2000-10-31 PL PL366314A patent/PL200273B1/pl unknown
- 2000-10-31 TR TR2002/00951T patent/TR200200951T2/xx unknown
- 2000-10-31 KR KR10-2002-7005613A patent/KR100493836B1/ko not_active IP Right Cessation
- 2000-10-31 IL IL14914700A patent/IL149147A0/xx unknown
- 2000-10-31 CA CA2388609A patent/CA2388609C/en not_active Expired - Fee Related
- 2000-10-31 EP EP00983101A patent/EP1242091B1/en not_active Expired - Lifetime
- 2000-10-31 JP JP2001534388A patent/JP2003514780A/ja not_active Withdrawn
- 2000-10-31 CN CN00814884A patent/CN1407894A/zh active Pending
- 2000-10-31 WO PCT/EP2000/010764 patent/WO2001032183A2/en active Application Filing
- 2000-10-31 SK SK584-2002A patent/SK287479B6/sk not_active IP Right Cessation
-
2002
- 2002-04-15 IL IL149147A patent/IL149147A/en not_active IP Right Cessation
- 2002-04-29 ZA ZA200203394A patent/ZA200203394B/en unknown
- 2002-04-30 NO NO20022058A patent/NO330947B1/no not_active IP Right Cessation
-
2003
- 2003-02-17 HK HK03101121.7A patent/HK1050839B/zh not_active IP Right Cessation
-
2005
- 2005-10-11 US US11/247,932 patent/US20060079502A1/en not_active Abandoned
-
2006
- 2006-10-18 US US11/582,801 patent/US20070037792A1/en not_active Abandoned
-
2007
- 2007-04-18 JP JP2007109439A patent/JP2007224041A/ja active Pending
-
2009
- 2009-03-23 US US12/408,770 patent/US20090252793A1/en not_active Abandoned
-
2010
- 2010-05-03 IL IL205504A patent/IL205504A0/en unknown
-
2012
- 2012-08-03 JP JP2012172912A patent/JP2012211202A/ja active Pending
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