PL3248978T3 - Zdeuterowane związki morfinanu - Google Patents

Zdeuterowane związki morfinanu

Info

Publication number
PL3248978T3
PL3248978T3 PL17179704T PL17179704T PL3248978T3 PL 3248978 T3 PL3248978 T3 PL 3248978T3 PL 17179704 T PL17179704 T PL 17179704T PL 17179704 T PL17179704 T PL 17179704T PL 3248978 T3 PL3248978 T3 PL 3248978T3
Authority
PL
Poland
Prior art keywords
morphinan compounds
deuterated
deuterated morphinan
compounds
morphinan
Prior art date
Application number
PL17179704T
Other languages
English (en)
Inventor
Philip B. Graham
I. Robert Silverman
Original Assignee
Concert Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concert Pharmaceuticals Inc. filed Critical Concert Pharmaceuticals Inc.
Publication of PL3248978T3 publication Critical patent/PL3248978T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
PL17179704T 2008-09-19 2009-09-18 Zdeuterowane związki morfinanu PL3248978T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US9851108P 2008-09-19 2008-09-19
PCT/US2009/057476 WO2010033801A1 (en) 2008-09-19 2009-09-18 Morphinan compounds
EP11188848.3A EP2418211B1 (en) 2008-09-19 2009-09-18 Deuterated morphinane compounds
EP14179393.5A EP2805950B1 (en) 2008-09-19 2009-09-18 Deuterated morphinan compounds
EP17179704.6A EP3248978B1 (en) 2008-09-19 2009-09-18 Deuterated morphinan compounds
EP09792714A EP2334678B1 (en) 2008-09-19 2009-09-18 Morphinan compounds

Publications (1)

Publication Number Publication Date
PL3248978T3 true PL3248978T3 (pl) 2019-12-31

Family

ID=41213342

Family Applications (3)

Application Number Title Priority Date Filing Date
PL09792714T PL2334678T3 (pl) 2008-09-19 2009-09-18 Związki morfinanu
PL17179704T PL3248978T3 (pl) 2008-09-19 2009-09-18 Zdeuterowane związki morfinanu
PL11188848.3T PL2418211T3 (pl) 2008-09-19 2009-09-18 Zdeuterowane związki morfinanu

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL09792714T PL2334678T3 (pl) 2008-09-19 2009-09-18 Związki morfinanu

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL11188848.3T PL2418211T3 (pl) 2008-09-19 2009-09-18 Zdeuterowane związki morfinanu

Country Status (19)

Country Link
US (9) US8710072B2 (pl)
EP (5) EP2634187B1 (pl)
JP (2) JP5730769B2 (pl)
KR (2) KR101716512B1 (pl)
CN (1) CN102197037B (pl)
AU (1) AU2009293123B2 (pl)
BR (1) BRPI0918760A2 (pl)
CA (1) CA2737811C (pl)
DK (2) DK3248978T3 (pl)
EA (3) EA030882B1 (pl)
ES (4) ES2402088T3 (pl)
HK (1) HK1154856A1 (pl)
MX (2) MX2011002994A (pl)
PH (1) PH12013501341A1 (pl)
PL (3) PL2334678T3 (pl)
PT (2) PT3248978T (pl)
SI (1) SI2334678T1 (pl)
WO (1) WO2010033801A1 (pl)
ZA (1) ZA201102113B (pl)

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