ZA200200221B - Aminothiazole derivatives and their use as CRF receptor ligands. - Google Patents
Aminothiazole derivatives and their use as CRF receptor ligands. Download PDFInfo
- Publication number
- ZA200200221B ZA200200221B ZA200200221A ZA200200221A ZA200200221B ZA 200200221 B ZA200200221 B ZA 200200221B ZA 200200221 A ZA200200221 A ZA 200200221A ZA 200200221 A ZA200200221 A ZA 200200221A ZA 200200221 B ZA200200221 B ZA 200200221B
- Authority
- ZA
- South Africa
- Prior art keywords
- methylphenyl
- alkyl
- methylthiazol
- chloro
- methoxy
- Prior art date
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9909144A FR2796380B3 (fr) | 1999-07-15 | 1999-07-15 | Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200200221B true ZA200200221B (en) | 2003-04-30 |
Family
ID=9548107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200200221A ZA200200221B (en) | 1999-07-15 | 2002-01-10 | Aminothiazole derivatives and their use as CRF receptor ligands. |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US6586456B1 (zh) |
| EP (1) | EP1200419B1 (zh) |
| JP (1) | JP4949582B2 (zh) |
| KR (1) | KR100707320B1 (zh) |
| CN (1) | CN1167692C (zh) |
| AR (1) | AR024747A1 (zh) |
| AT (1) | ATE264315T1 (zh) |
| AU (1) | AU772683B2 (zh) |
| BR (1) | BR0012478B1 (zh) |
| CA (1) | CA2378792C (zh) |
| CO (1) | CO5200792A1 (zh) |
| CZ (1) | CZ300937B6 (zh) |
| DE (1) | DE60009911T2 (zh) |
| DK (1) | DK1200419T3 (zh) |
| EA (1) | EA005159B1 (zh) |
| EE (1) | EE05004B1 (zh) |
| ES (1) | ES2220504T3 (zh) |
| FR (1) | FR2796380B3 (zh) |
| HK (1) | HK1045692B (zh) |
| HU (1) | HU229069B1 (zh) |
| IL (2) | IL147282A0 (zh) |
| IS (1) | IS2314B (zh) |
| ME (1) | MEP26608A (zh) |
| MX (1) | MXPA02000545A (zh) |
| NO (1) | NO324352B1 (zh) |
| NZ (1) | NZ516397A (zh) |
| PL (1) | PL206515B1 (zh) |
| PT (1) | PT1200419E (zh) |
| RS (1) | RS50443B (zh) |
| SI (1) | SI1200419T1 (zh) |
| SK (1) | SK287069B6 (zh) |
| TR (1) | TR200200125T2 (zh) |
| TW (1) | TWI278453B (zh) |
| UA (1) | UA73125C2 (zh) |
| WO (1) | WO2001005776A1 (zh) |
| ZA (1) | ZA200200221B (zh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1320365A4 (en) * | 2000-09-21 | 2004-03-17 | Bristol Myers Squibb Co | SUBSTITUTED AZOLE DERIVATIVES AS AN INHIBITOR OF THE CORTICOTROPIN RELEASE FACTOR |
| WO2003015777A1 (en) * | 2001-08-13 | 2003-02-27 | Lion Bioscience Ag | Nr1h4 nuclear receptor binding compounds |
| WO2003033128A2 (en) | 2001-10-12 | 2003-04-24 | Duke University | Methods for image analysis of high-density synthetic dna microarrays |
| EP2270034A3 (en) | 2004-06-03 | 2011-06-01 | Athlomics Pty Ltd | Agents and methods for diagnosing stress |
| CA2575466A1 (en) * | 2004-08-13 | 2006-02-23 | Genentech, Inc. | Thiazole based inhibitors of atp-utilizing enzymes |
| EP1834641A1 (en) * | 2006-03-16 | 2007-09-19 | Sanofi-Aventis | Use of CRF1 receptor antagonists for preparing a drug for treating metabolic syndrome and/or obesity and/or dyslipoproteinemia |
| HUP0900267A2 (en) * | 2009-04-30 | 2011-03-28 | Sanofi Aventis | Process for preparing of thiazole amines and intermediates thereof |
| WO2013160317A2 (en) * | 2012-04-23 | 2013-10-31 | Holsboermaschmeyer Neurochemie Gmbh | Crhr1 antagonists for use in the treatment of patients having crh overactivity |
| GB201210686D0 (en) | 2012-06-15 | 2012-08-01 | Holsboermaschmeyer Neurochemie Gmbh | V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level |
| GB201310782D0 (en) | 2013-06-17 | 2013-07-31 | Max Planck Innovation Gmbh | Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms |
| JP6585625B2 (ja) | 2014-01-21 | 2019-10-02 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
| JP2022000473A (ja) * | 2018-12-07 | 2022-01-04 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト、その医薬製剤および固体形態 |
| JP7238130B2 (ja) | 2018-12-07 | 2023-03-13 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト、その医薬製剤および固体形態 |
| CN114502162A (zh) * | 2019-09-27 | 2022-05-13 | 纽罗克里生物科学有限公司 | Crf受体拮抗剂及使用方法 |
| US20230255942A1 (en) | 2020-06-10 | 2023-08-17 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonist for the treatment of congenital adrenal hyperplasia |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2692893B1 (fr) | 1992-06-24 | 1994-09-02 | Sanofi Elf | Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2714059B1 (fr) * | 1993-12-21 | 1996-03-08 | Sanofi Elf | Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2735777B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| FR2754258B1 (fr) * | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
-
1999
- 1999-07-15 FR FR9909144A patent/FR2796380B3/fr not_active Expired - Lifetime
-
2000
- 2000-07-11 IL IL14728200A patent/IL147282A0/xx active IP Right Grant
- 2000-07-11 HU HU0202387A patent/HU229069B1/hu not_active IP Right Cessation
- 2000-07-11 US US10/031,038 patent/US6586456B1/en not_active Expired - Lifetime
- 2000-07-11 PL PL352901A patent/PL206515B1/pl unknown
- 2000-07-11 PT PT00951647T patent/PT1200419E/pt unknown
- 2000-07-11 WO PCT/FR2000/001995 patent/WO2001005776A1/fr active IP Right Grant
- 2000-07-11 RS YUP-13/02A patent/RS50443B/sr unknown
- 2000-07-11 JP JP2001511437A patent/JP4949582B2/ja not_active Expired - Lifetime
- 2000-07-11 DE DE60009911T patent/DE60009911T2/de not_active Expired - Lifetime
- 2000-07-11 ES ES00951647T patent/ES2220504T3/es not_active Expired - Lifetime
- 2000-07-11 CZ CZ20020137A patent/CZ300937B6/cs not_active IP Right Cessation
- 2000-07-11 SK SK38-2002A patent/SK287069B6/sk not_active IP Right Cessation
- 2000-07-11 MX MXPA02000545A patent/MXPA02000545A/es active IP Right Grant
- 2000-07-11 EP EP00951647A patent/EP1200419B1/fr not_active Expired - Lifetime
- 2000-07-11 AT AT00951647T patent/ATE264315T1/de active
- 2000-07-11 SI SI200030377T patent/SI1200419T1/xx unknown
- 2000-07-11 CA CA002378792A patent/CA2378792C/en not_active Expired - Fee Related
- 2000-07-11 CN CNB008116911A patent/CN1167692C/zh not_active Expired - Fee Related
- 2000-07-11 EA EA200101234A patent/EA005159B1/ru not_active IP Right Cessation
- 2000-07-11 DK DK00951647T patent/DK1200419T3/da active
- 2000-07-11 EE EEP200200022A patent/EE05004B1/xx not_active IP Right Cessation
- 2000-07-11 AU AU64521/00A patent/AU772683B2/en not_active Ceased
- 2000-07-11 TR TR2002/00125T patent/TR200200125T2/xx unknown
- 2000-07-11 BR BRPI0012478-8B1A patent/BR0012478B1/pt not_active IP Right Cessation
- 2000-07-11 KR KR1020027000549A patent/KR100707320B1/ko not_active IP Right Cessation
- 2000-07-11 ME MEP-266/08A patent/MEP26608A/xx unknown
- 2000-07-11 NZ NZ516397A patent/NZ516397A/xx not_active IP Right Cessation
- 2000-07-13 CO CO00052852A patent/CO5200792A1/es active IP Right Grant
- 2000-07-14 TW TW089114114A patent/TWI278453B/zh not_active IP Right Cessation
- 2000-07-14 AR ARP000103626A patent/AR024747A1/es not_active Application Discontinuation
- 2000-11-07 UA UA2001129084A patent/UA73125C2/uk unknown
-
2001
- 2001-12-24 IL IL147282A patent/IL147282A/en not_active IP Right Cessation
-
2002
- 2002-01-03 IS IS6219A patent/IS2314B/is unknown
- 2002-01-10 ZA ZA200200221A patent/ZA200200221B/en unknown
- 2002-01-11 NO NO20020155A patent/NO324352B1/no not_active IP Right Cessation
- 2002-10-04 HK HK02107310.6A patent/HK1045692B/zh not_active IP Right Cessation
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2007
- 2007-04-25 US US11/740,001 patent/US8420679B2/en not_active Expired - Lifetime
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