YU55199A - Stereoselektivna mikrobska redukcija jednog racemskog tetralona - Google Patents

Stereoselektivna mikrobska redukcija jednog racemskog tetralona

Info

Publication number
YU55199A
YU55199A YU55199A YU55199A YU55199A YU 55199 A YU55199 A YU 55199A YU 55199 A YU55199 A YU 55199A YU 55199 A YU55199 A YU 55199A YU 55199 A YU55199 A YU 55199A
Authority
YU
Yugoslavia
Prior art keywords
formula
tetralone
reduction
enzime
subject matter
Prior art date
Application number
YU55199A
Other languages
English (en)
Inventor
Knight Morse Brook
Susan Jane Truesdell
John Wing Wong
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of YU55199A publication Critical patent/YU55199A/sh
Publication of RS49702B publication Critical patent/RS49702B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Prikazani pronalazak se odnosi na postupak za izvodjenje sledece stereoselektivne redukcije jednog racemskog tetralona: i obuhvata: dovodjenje u dodir jedinjenja formule (I) sa jednim mikroorganizmom, ili enzimskim sistemom za redukovanje koji je u stanju da izvrsi predmetno redukovanje a koji sadrzi jedan enzim izveden iz pomenutog mikroorganizma i jedan ko-faktor za pomenuti enzim, i inkubaciju dobijene mesavine pod uslovima dovoljnim da se dobije (4R) tetralol formule (II) a ostavlja u sustini nereagovani (4S) tetralon formule (V) ili "hiralni tetralon". Hiralni se tetralon moze koristiti u sintezi sertralina. Predmetni postupak dalje sadrzi, ako se zeli, razdvajanje (4S) tetralona formule (V) od (4R) tetralola formule (II). (4R) tetralol moze se potom oksidisati da bi se dobilo jedinjenje formule (I) pa se predmetna mikrobska redukcija moze ponoviti da bi se dobilo jos vise zeljenog (4S) tetralona formule (V).
YUP-551/99A 1998-10-29 1999-10-27 Stereoselektivna mikrobska redukcija racemskog tetralona RS49702B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10623398P 1998-10-29 1998-10-29

Publications (2)

Publication Number Publication Date
YU55199A true YU55199A (sh) 2003-04-30
RS49702B RS49702B (sr) 2007-12-31

Family

ID=22310267

Country Status (27)

Country Link
US (1) US6589777B1 (sh)
EP (1) EP0997535B1 (sh)
JP (2) JP3106135B2 (sh)
KR (2) KR100432309B1 (sh)
CN (1) CN1252277C (sh)
AR (1) AR018967A1 (sh)
AT (1) ATE328107T1 (sh)
AU (1) AU751282B2 (sh)
BR (1) BR9904964A (sh)
CA (1) CA2287560C (sh)
CY (1) CY1105148T1 (sh)
CZ (1) CZ293579B6 (sh)
DE (1) DE69931574T2 (sh)
DK (1) DK0997535T3 (sh)
ES (1) ES2264244T3 (sh)
HK (1) HK1027596A1 (sh)
HU (1) HUP9903941A3 (sh)
ID (1) ID23591A (sh)
IL (1) IL132500A0 (sh)
IN (1) IN191494B (sh)
PL (1) PL336331A1 (sh)
PT (1) PT997535E (sh)
RS (1) RS49702B (sh)
RU (1) RU2235784C2 (sh)
TR (1) TR199902668A2 (sh)
TW (1) TWI224141B (sh)
ZA (1) ZA996786B (sh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN187170B (sh) * 2000-01-04 2002-02-23 Sun Pharmaceutical Ind Ltd
JP4303117B2 (ja) * 2001-11-28 2009-07-29 株式会社カネカ ２−アミノテトラリン誘導体の製造方法およびその中間体
WO2015071861A2 (en) * 2013-11-14 2015-05-21 Biocon Limited Fungus mediated stereo-selective bioreduction of keto intermediates of pharmaceutically active compounds to their corresponding hydroxy compounds
CN104293856A (zh) * 2014-10-30 2015-01-21 青岛科技大学 一种细胞催化生产氟吡啶乙酮的方法
CN107418981B (zh) * 2017-06-27 2020-04-07 中山大学 白地霉菌株不对称催化还原卤代芳香酮的方法
CN107746861B (zh) * 2017-11-20 2020-06-23 浙江工业大学 一种(r)-1-(2-三氟甲基苯基)乙醇的生物制备方法
KR102319188B1 (ko) * 2019-06-04 2021-10-29 (주)이엔씨파워 횡단보도용 양면 표지판

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4857468A (en) * 1985-04-13 1989-08-15 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for preparing optically active 2-halo-1-phenyl ethanol
US5049497A (en) 1986-08-25 1991-09-17 Syntex (U.S.A.) Inc. Novel process for the synthesis of the enantiomers of bicyclo(4.2.0)oct-2-en-7-one and derivatives
US4839104A (en) 1987-06-11 1989-06-13 Pfizer, Inc. Process for preparing sertraline intermediates
US4777288A (en) 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
US4855500A (en) 1988-05-04 1989-08-08 Pfizer Inc. Process for preparing a ketimine
US5130338A (en) 1989-08-30 1992-07-14 Pfizer Inc. Method of treating chemical dependencies using sertraline
US4940731A (en) 1989-08-30 1990-07-10 Pfizer Inc. Method of treating premature ejaculation using sertraline
US4962128A (en) 1989-11-02 1990-10-09 Pfizer Inc. Method of treating anxiety-related disorders using sertraline
US5082970A (en) 1991-03-06 1992-01-21 Pfizer Inc. Process for recycling amine isomer
GB9114947D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
US5196607A (en) 1992-02-14 1993-03-23 Pfizer Inc. Process for preparing ketone enantiomer
JP3672307B2 (ja) 1992-03-13 2005-07-20 フォルシュングスツェントルム・ユーリッヒ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 新規ケトエステル‐還元酵素，その製造方法及びこれを酵素酸化還元反応に使用する方法
US5248699A (en) 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
ES2093980T3 (es) 1992-08-28 1997-01-01 Zeneca Ltd Proceso de reduccion asimetrica, enzimatica, para producir derivados de 4h-tieno(2,3-6)tiopirano.
US5466880A (en) 1992-09-15 1995-11-14 Pfizer Inc. Process for preparing ketone enantiomer
US5750794A (en) * 1993-11-30 1998-05-12 Pfizer Inc. Process for preparing chiral tetralone
US5597826A (en) 1994-09-14 1997-01-28 Pfizer Inc. Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist
US5618707A (en) 1996-01-04 1997-04-08 Schering Corporation Stereoselective microbial reduction of 5-fluorophenyl-5-oxo-pentanoic acid and a phenyloxazolidinone condensation product thereof

Also Published As

Publication number Publication date
KR100432306B1 (ko) 2004-05-20
DE69931574D1 (de) 2006-07-06
DK0997535T3 (da) 2006-10-02
KR100432309B1 (ko) 2004-05-20
JP3106135B2 (ja) 2000-11-06
IL132500A0 (en) 2001-03-19
EP0997535A2 (en) 2000-05-03
CN1255551A (zh) 2000-06-07
HU9903941D0 (en) 1999-12-28
CY1105148T1 (el) 2010-03-03
CZ293579B6 (cs) 2004-06-16
ZA996786B (en) 2001-04-30
JP3359905B2 (ja) 2002-12-24
CA2287560C (en) 2003-08-19
CA2287560A1 (en) 2000-04-29
ATE328107T1 (de) 2006-06-15
AU751282B2 (en) 2002-08-08
DE69931574T2 (de) 2006-11-02
CN1252277C (zh) 2006-04-19
IN191494B (sh) 2003-12-06
KR20030071731A (ko) 2003-09-06
HK1027596A1 (en) 2001-01-19
PT997535E (pt) 2006-10-31
HUP9903941A2 (hu) 2000-12-28
JP2000135098A (ja) 2000-05-16
AU5709799A (en) 2000-05-04
RS49702B (sr) 2007-12-31
KR20000029385A (ko) 2000-05-25
ID23591A (id) 2000-05-04
RU2235784C2 (ru) 2004-09-10
TWI224141B (en) 2004-11-21
HUP9903941A3 (en) 2001-04-28
ES2264244T3 (es) 2006-12-16
EP0997535A3 (en) 2000-10-18
US6589777B1 (en) 2003-07-08
CZ379099A3 (cs) 2000-05-17
JP2001054397A (ja) 2001-02-27
PL336331A1 (en) 2000-05-08
EP0997535B1 (en) 2006-05-31
AR018967A1 (es) 2001-12-12
TR199902668A2 (xx) 2000-05-22
BR9904964A (pt) 2000-12-12

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