AR018967A1 - Proceso para la reduccion microbiana estereoselectiva de una tetralona racemica. - Google Patents
Proceso para la reduccion microbiana estereoselectiva de una tetralona racemica.Info
- Publication number
- AR018967A1 AR018967A1 ARP990105423A ARP990105423A AR018967A1 AR 018967 A1 AR018967 A1 AR 018967A1 AR P990105423 A ARP990105423 A AR P990105423A AR P990105423 A ARP990105423 A AR P990105423A AR 018967 A1 AR018967 A1 AR 018967A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- tetralone
- tetralol
- produce
- reduction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente se refiere a procedimientos para llevar a cabo la siguiente reduccion microbiana estereoselectiva de una tetralona racémica que comprende:poner en contacto un compuesto de formula (I) con un microorganismo, o un sistema de reduccionenzim ática capaz de llevar a cabo la presente reduccion, quecomprende una enzima derivada de dicho microorganismo y un cofactor para dicha enzima, e incubar la mezcla resultante bajo condiciones suficientes paraproducir el (4R) tetralol de formula(II) y dejar sustancialmente sin reaccionar la (4S) tetralona de formula (V) tetralona quiral. La tetralona quiralse puede usar en la síntesis de sertralina. El presente procedimiento comprende además opcionalmente la separacion de la (4S) tetralonade form ula (V) del(4R)tetralol de formula (II). El (4R) tetralol se puede reciclar para producir el compuesto de formula (I) y el presente procedimiento se repite para producir más(4S) tetralona deseada de formula (V).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10623398P | 1998-10-29 | 1998-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR018967A1 true AR018967A1 (es) | 2001-12-12 |
Family
ID=22310267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990105423A AR018967A1 (es) | 1998-10-29 | 1999-10-27 | Proceso para la reduccion microbiana estereoselectiva de una tetralona racemica. |
Country Status (27)
Country | Link |
---|---|
US (1) | US6589777B1 (es) |
EP (1) | EP0997535B1 (es) |
JP (2) | JP3106135B2 (es) |
KR (2) | KR100432309B1 (es) |
CN (1) | CN1252277C (es) |
AR (1) | AR018967A1 (es) |
AT (1) | ATE328107T1 (es) |
AU (1) | AU751282B2 (es) |
BR (1) | BR9904964A (es) |
CA (1) | CA2287560C (es) |
CY (1) | CY1105148T1 (es) |
CZ (1) | CZ293579B6 (es) |
DE (1) | DE69931574T2 (es) |
DK (1) | DK0997535T3 (es) |
ES (1) | ES2264244T3 (es) |
HK (1) | HK1027596A1 (es) |
HU (1) | HUP9903941A3 (es) |
ID (1) | ID23591A (es) |
IL (1) | IL132500A0 (es) |
IN (1) | IN191494B (es) |
PL (1) | PL336331A1 (es) |
PT (1) | PT997535E (es) |
RS (1) | RS49702B (es) |
RU (1) | RU2235784C2 (es) |
TR (1) | TR199902668A2 (es) |
TW (1) | TWI224141B (es) |
ZA (1) | ZA996786B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN187170B (es) * | 2000-01-04 | 2002-02-23 | Sun Pharmaceutical Ind Ltd | |
JP4303117B2 (ja) * | 2001-11-28 | 2009-07-29 | 株式会社カネカ | 2−アミノテトラリン誘導体の製造方法およびその中間体 |
WO2015071861A2 (en) * | 2013-11-14 | 2015-05-21 | Biocon Limited | Fungus mediated stereo-selective bioreduction of keto intermediates of pharmaceutically active compounds to their corresponding hydroxy compounds |
CN104293856A (zh) * | 2014-10-30 | 2015-01-21 | 青岛科技大学 | 一种细胞催化生产氟吡啶乙酮的方法 |
CN107418981B (zh) * | 2017-06-27 | 2020-04-07 | 中山大学 | 白地霉菌株不对称催化还原卤代芳香酮的方法 |
CN107746861B (zh) * | 2017-11-20 | 2020-06-23 | 浙江工业大学 | 一种(r)-1-(2-三氟甲基苯基)乙醇的生物制备方法 |
KR102319188B1 (ko) * | 2019-06-04 | 2021-10-29 | (주)이엔씨파워 | 횡단보도용 양면 표지판 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4536518A (en) | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
US4857468A (en) * | 1985-04-13 | 1989-08-15 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Process for preparing optically active 2-halo-1-phenyl ethanol |
US5049497A (en) | 1986-08-25 | 1991-09-17 | Syntex (U.S.A.) Inc. | Novel process for the synthesis of the enantiomers of bicyclo(4.2.0)oct-2-en-7-one and derivatives |
US4839104A (en) | 1987-06-11 | 1989-06-13 | Pfizer, Inc. | Process for preparing sertraline intermediates |
US4777288A (en) | 1987-06-11 | 1988-10-11 | Pfizer Inc. | Process for preparing a 4,4-diphenylbutanoic acid derivative |
US4855500A (en) | 1988-05-04 | 1989-08-08 | Pfizer Inc. | Process for preparing a ketimine |
US5130338A (en) | 1989-08-30 | 1992-07-14 | Pfizer Inc. | Method of treating chemical dependencies using sertraline |
US4940731A (en) | 1989-08-30 | 1990-07-10 | Pfizer Inc. | Method of treating premature ejaculation using sertraline |
US4962128A (en) | 1989-11-02 | 1990-10-09 | Pfizer Inc. | Method of treating anxiety-related disorders using sertraline |
US5082970A (en) | 1991-03-06 | 1992-01-21 | Pfizer Inc. | Process for recycling amine isomer |
GB9114947D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
US5196607A (en) | 1992-02-14 | 1993-03-23 | Pfizer Inc. | Process for preparing ketone enantiomer |
DE59306681D1 (de) | 1992-03-13 | 1997-07-10 | Forschungszentrum Juelich Gmbh | Neue ketoester-reduktase, deren herstellung und verwendung für enzymatische redoxreaktionen |
US5248699A (en) | 1992-08-13 | 1993-09-28 | Pfizer Inc. | Sertraline polymorph |
DK0658211T4 (da) | 1992-08-28 | 2004-04-13 | Avecia Ltd | Enzymatisk, asymmetrisk reduktionsfremgangsmåde til fremstilling af 4H-thieno(2,3-6)thiopyranderivater |
US5466880A (en) | 1992-09-15 | 1995-11-14 | Pfizer Inc. | Process for preparing ketone enantiomer |
JP2686366B2 (ja) * | 1993-11-30 | 1997-12-08 | ファイザー・インコーポレーテッド | キラルテトラロンの製造方法 |
US5597826A (en) | 1994-09-14 | 1997-01-28 | Pfizer Inc. | Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist |
US5618707A (en) | 1996-01-04 | 1997-04-08 | Schering Corporation | Stereoselective microbial reduction of 5-fluorophenyl-5-oxo-pentanoic acid and a phenyloxazolidinone condensation product thereof |
-
1999
- 1999-10-21 IL IL13250099A patent/IL132500A0/xx not_active IP Right Cessation
- 1999-10-22 IN IN1409DE1999 patent/IN191494B/en unknown
- 1999-10-25 PT PT99308422T patent/PT997535E/pt unknown
- 1999-10-25 DE DE69931574T patent/DE69931574T2/de not_active Expired - Fee Related
- 1999-10-25 DK DK99308422T patent/DK0997535T3/da active
- 1999-10-25 TW TW088118421A patent/TWI224141B/zh not_active IP Right Cessation
- 1999-10-25 CZ CZ19993790A patent/CZ293579B6/cs not_active IP Right Cessation
- 1999-10-25 EP EP99308422A patent/EP0997535B1/en not_active Expired - Lifetime
- 1999-10-25 AT AT99308422T patent/ATE328107T1/de not_active IP Right Cessation
- 1999-10-25 ES ES99308422T patent/ES2264244T3/es not_active Expired - Lifetime
- 1999-10-26 US US09/427,424 patent/US6589777B1/en not_active Expired - Fee Related
- 1999-10-26 TR TR1999/02668A patent/TR199902668A2/xx unknown
- 1999-10-27 RS YUP-551/99A patent/RS49702B/sr unknown
- 1999-10-27 ID IDP990987D patent/ID23591A/id unknown
- 1999-10-27 AR ARP990105423A patent/AR018967A1/es active IP Right Grant
- 1999-10-27 CA CA002287560A patent/CA2287560C/en not_active Expired - Fee Related
- 1999-10-28 JP JP11307272A patent/JP3106135B2/ja not_active Expired - Fee Related
- 1999-10-28 AU AU57097/99A patent/AU751282B2/en not_active Ceased
- 1999-10-28 RU RU99122704/13A patent/RU2235784C2/ru not_active IP Right Cessation
- 1999-10-28 HU HU9903941A patent/HUP9903941A3/hu unknown
- 1999-10-28 ZA ZA9906786A patent/ZA996786B/xx unknown
- 1999-10-28 PL PL99336331A patent/PL336331A1/xx not_active IP Right Cessation
- 1999-10-28 KR KR10-1999-0047145A patent/KR100432309B1/ko not_active IP Right Cessation
- 1999-10-28 BR BR9904964-3A patent/BR9904964A/pt not_active Application Discontinuation
- 1999-10-28 CN CNB991233883A patent/CN1252277C/zh not_active Expired - Fee Related
-
2000
- 2000-06-30 JP JP2000198150A patent/JP3359905B2/ja not_active Expired - Fee Related
- 2000-10-23 HK HK00106703A patent/HK1027596A1/xx not_active IP Right Cessation
-
2003
- 2003-08-20 KR KR10-2003-0057440A patent/KR100432306B1/ko not_active IP Right Cessation
-
2006
- 2006-08-10 CY CY20061101126T patent/CY1105148T1/el unknown
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