YU47880B - Protein i postupak za dobijanje proteina - Google Patents

Protein i postupak za dobijanje proteina

Info

Publication number
YU47880B
YU47880B YU113889A YU113889A YU47880B YU 47880 B YU47880 B YU 47880B YU 113889 A YU113889 A YU 113889A YU 113889 A YU113889 A YU 113889A YU 47880 B YU47880 B YU 47880B
Authority
YU
Yugoslavia
Prior art keywords
protein
procedure
obtaining
dna strand
accessions
Prior art date
Application number
YU113889A
Other languages
English (en)
Other versions
YU113889A (en
Inventor
W. Altenburger
M.-H. Binger
R.A. Chizzonite
R.A. Kramer
P.T. Lomedico
J.S. Mcandrew
Original Assignee
F.Hoffmann-La Roche & Co. Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche & Co. Ag. filed Critical F.Hoffmann-La Roche & Co. Ag.
Publication of YU113889A publication Critical patent/YU113889A/xx
Publication of YU47880B publication Critical patent/YU47880B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/455—Eimeria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROTEIN I POSTUPAK ZA DOBIJANJE PROTEINA, protein koji ima jednu ili više antigenskih determinanti za površinski antigen Eimeria, naznačen time, što ima jedan od nizova amino kiselina prikazanih na slikama 17, 19 ili 21, ili je njegovo funkcionalni ekvivalent i specifično se vezuje za jedno ili više monoklonskih antitela deponovanih kod Američke Kolekcije Tipova Kultura i označenih pristupima br. HB 9707 do HB 9710 i HB 9712. Postupak za dobivanje proteina prema zahtevu 1, naznačen ti me, što obuhvata: a) kultivisanje organizma domaćina transformisanog rekom-binantnim vektorom koji obuhvata DNA niz koji kodira pomenuti protein pod uslovima u kojima je ovaj DNA niz eksprimiran, i b) izolovanje proteina iz ove kulture. Prijava sadrži još 1 nezavisan i 11 zavisnih zahteva.
YU113889A 1988-06-03 1989-06-02 Protein i postupak za dobijanje proteina YU47880B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20272188A 1988-06-03 1988-06-03

Publications (2)

Publication Number Publication Date
YU113889A YU113889A (en) 1991-10-31
YU47880B true YU47880B (sh) 1996-05-20

Family

ID=22750986

Family Applications (1)

Application Number Title Priority Date Filing Date
YU113889A YU47880B (sh) 1988-06-03 1989-06-02 Protein i postupak za dobijanje proteina

Country Status (22)

Country Link
US (2) US5661015A (sh)
EP (1) EP0344808B1 (sh)
JP (1) JP3051130B2 (sh)
KR (1) KR0156545B1 (sh)
CN (3) CN1040126C (sh)
AR (1) AR241942A1 (sh)
AT (1) ATE120489T1 (sh)
AU (1) AU635704B2 (sh)
CA (1) CA1340538C (sh)
DE (1) DE68921923T2 (sh)
DK (1) DK272889A (sh)
ES (1) ES2070866T3 (sh)
FI (1) FI101453B (sh)
HU (1) HU212505B (sh)
IE (1) IE67544B1 (sh)
IL (1) IL90489A0 (sh)
MC (1) MC2039A1 (sh)
NO (1) NO303876B1 (sh)
NZ (1) NZ229377A (sh)
PT (1) PT90727B (sh)
YU (1) YU47880B (sh)
ZA (1) ZA893740B (sh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5174993A (en) * 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US5279960A (en) * 1984-07-05 1994-01-18 Enzon Corp. 25 KD coccidial antigen of eimeria tenella
US5273901A (en) * 1984-07-05 1993-12-28 Enzon Corp. Genetically engineered coccidiosis sporozoite 21.5 Kb antigen, ac-6b
US5824656A (en) * 1988-01-15 1998-10-20 Merck & Co., Inc. Recombinant and native group B eimeria tenella immunogens useful as coccidiosis vaccines
DE68927350T2 (de) * 1988-07-05 1997-04-24 British Tech Group Usa Gentechnologisch hergestellter coccidiose-impfstoff
ZA902147B (en) * 1989-03-28 1990-12-28 Akzo Nv Coccidiosis vaccine
ATE94208T1 (de) * 1989-06-21 1993-09-15 Akzo Nv Eimeria tenella-vakzin.
ZA9010461B (en) * 1990-01-26 1991-10-30 Hoffmann La Roche Recombinant coccidiosis vaccines-5-7 eimeria surface antigen
JPH07500483A (ja) * 1991-03-14 1995-01-19 ブリティッシュ・テクノロジー・グループ・ユーエスエイ・インコーポレーテッド 組換え体抗コクシジアワクチン
US6008342A (en) * 1991-07-12 1999-12-28 Roche Vitamins Inc. DNA encoding eimeria antigen
US5403581A (en) * 1991-07-12 1995-04-04 Hoffmann-La Roche Inc. Coccidiosis vaccines
JP3534774B2 (ja) 1995-06-07 2004-06-07 ファイザー・インク コクシジウム症に対する卵内予防接種
US6500438B2 (en) 1995-06-07 2002-12-31 Pfizer Incorporated In ovo vaccination against coccidiosis
ES2253746T3 (es) * 1995-07-03 2006-06-01 Akzo Nobel N.V. Vacuna contra la coccidiosis aviar.
AU2590997A (en) * 1996-03-29 1997-10-22 Life Technologies, Inc. Method for increasing viability and transformation efficiency of bacteria during storage at low temperatures
US6632923B1 (en) * 1996-11-27 2003-10-14 Boston Heart Foundation, Inc. Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
US6627205B2 (en) 1997-12-01 2003-09-30 Pfizer Incorporated Ovo vaccination against coccidiosis
US6984378B1 (en) 1999-02-26 2006-01-10 Pfizer, Inc. Method for the purification, recovery, and sporulation of cysts and oocysts
ZA200400479B (en) * 2001-07-06 2006-05-31 Abic Biolog Lab Teva Nucleic acids encoding recombinant 56 a 82 KDA antigens from gametocytes of Eimeria maxima and their use
KR100490669B1 (ko) * 2001-08-30 2005-05-19 (주)아비코아생명공학연구소 조류 콕시듐증을 유발하는 에이메리아 종의 포자소체 표면항원에 대한 ｓｃＦｖ 재조합 항체
WO2003020917A1 (en) 2001-08-30 2003-03-13 Embrex, Inc. Improved methods for producing oocysts
JP3995541B2 (ja) * 2002-06-28 2007-10-24 株式会社ゲン・コーポレーション 抗鶏コクシジウム症組成物
DE10330235A1 (de) * 2003-07-04 2005-01-20 Bayer Healthcare Ag Neues Eimeria Gen und Protein sowie deren Verwendung
US7348401B2 (en) * 2003-09-10 2008-03-25 Innate Biotech, Inc. Peptides that inhibit complement activation
DE602005021873D1 (de) * 2004-03-12 2010-07-29 Univ Georgia Neues impfstoffadjuvans und dessen herstellung und verwendung
US7087425B2 (en) * 2004-03-31 2006-08-08 Embrex, Inc. Method of purifying oocysts using enzymatic digestion of fecal debris
US20110078828A1 (en) * 2004-09-10 2011-03-31 Guardian Biotechnologies Inc. Multi epitope vaccine for poultry
DE602005003429T2 (de) * 2004-12-01 2008-10-02 Zeon Corp. Kodierende DNS für ein Eimeria Apical Membran Antigen 1 und dessen Verwendungen
CN100398156C (zh) * 2005-11-23 2008-07-02 南京农业大学 用于预防鸡球虫病的免疫调节型dna疫苗
US20080194006A1 (en) * 2007-02-08 2008-08-14 Embrex, Inc. Methods of releasing sporocysts from oocysts using controlled shear forces
US11701683B2 (en) 2010-12-22 2023-07-18 The Procter & Gamble Company Methods for foil stamping parts having asymmetrical edges
US10758601B2 (en) 2016-12-22 2020-09-01 Intervet Inc. Eimeria vaccine with improved efficacy
WO2020243240A1 (en) * 2019-05-28 2020-12-03 Case Western Reserve University Compositions and methods for preserving dna methylation

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237224A (en) 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
DE2814039C3 (de) 1978-03-31 1981-02-19 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von Hybrid-Bakterien
EP0135073A3 (en) * 1983-08-19 1987-05-27 American Cyanamid Company Antigens and monoclonal antibodies reactive against merozites of eimeria spp.
US4650676A (en) 1983-08-19 1987-03-17 American Cyanamid Company Antigens and monoclonal antibodies reactive against merozoites of Eimeria spp.
US4710377A (en) * 1983-08-19 1987-12-01 American Cyanamid Company Antigens and monoclonal antibodies reactive against sporozoites of Eimeria spp.
EP0135712A3 (en) * 1983-08-19 1987-05-27 American Cyanamid Company Antigens and monoclonal antibodies reactive against sporozoites of eimeria spp.
US4874705A (en) * 1985-05-16 1989-10-17 Solvay & Cie, S.A. DNA encoding an antigenic protein derived from Eimeria tenella and vaccines for prevention of coccidiosis caused by Eimeria tenella
US5187080A (en) * 1984-06-05 1993-02-16 Solvay & Cie S.A. DNA encoding an antigenic protein derived from Eimeria tenella and vaccines for prevention of coccidiosis caused by Eimeria tenella
CA1340520C (en) * 1984-06-05 1999-05-04 Karel Z. Newman Jr. Antigenic proteins and vaccines containing them and protective antibodies directed to them for prevention of coccidiosis caused by eimeria tenella and eimeria necatrix
US4639372A (en) 1984-06-29 1987-01-27 Merck & Co., Inc. Coccidiosis vaccine
WO1986000528A1 (en) * 1984-07-05 1986-01-30 Genex Corporation Cloned gene and method for making and using the same
US5273901A (en) * 1984-07-05 1993-12-28 Enzon Corp. Genetically engineered coccidiosis sporozoite 21.5 Kb antigen, ac-6b
ES2109254T3 (es) * 1985-12-03 1998-01-16 Dimminaco Ag Sa Ltd Proteinas antigenas y vacunas que las contienen para la prevencion de cocidiosis.
EP0241139A3 (en) * 1986-03-13 1989-04-19 Merck & Co. Inc. Anti-idiotypic vaccine for coccidiosis
US5496550A (en) * 1986-08-14 1996-03-05 Chilwalner Method of reducing the output of Eimeria oocysts from a newborn chick
ATE145245T1 (de) * 1987-03-06 1996-11-15 Amgen Boulder Inc Polypeptide zur verwendung bei der diagnose von kokkidien-infektion und rekombinant-dns, verfahren zur herstellung derselben
EP0315073A2 (en) * 1987-11-02 1989-05-10 Matsushita Electric Industrial Co., Ltd. A composition for pattern forming materials
NZ227595A (en) * 1988-01-15 1991-11-26 Merck & Co Inc Recombinant production of eimeria tenella antigens and their use
NZ227597A (en) * 1988-01-15 1991-11-26 Merck & Co Inc Eimeria tenella group b immunogens and their production
AU620366B2 (en) * 1988-02-12 1992-02-20 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Cloned genes coding for avian coccidiosis antigens which induce a cell-mediated response and method of producing the same
DE3926461A1 (de) * 1989-07-15 1991-01-24 Suttner Gmbh & Co Kg Ventilpistole, insbesondere fuer ein hochdruckreinigungsgeraet

Also Published As

Publication number Publication date
CA1340538C (en) 1999-05-11
CN1076204C (zh) 2001-12-19
FI101453B1 (fi) 1998-06-30
PT90727A (pt) 1989-12-29
CN1186695A (zh) 1998-07-08
CN1187368A (zh) 1998-07-15
MC2039A1 (fr) 1990-05-30
ZA893740B (en) 1990-02-28
KR0156545B1 (ko) 1998-11-16
KR910000183A (ko) 1991-01-29
DE68921923D1 (de) 1995-05-04
JP3051130B2 (ja) 2000-06-12
PT90727B (pt) 1994-11-30
YU113889A (en) 1991-10-31
AU635704B2 (en) 1993-04-01
JPH037594A (ja) 1991-01-14
DK272889D0 (da) 1989-06-02
ES2070866T3 (es) 1995-06-16
AR241942A1 (es) 1993-01-29
EP0344808B1 (en) 1995-03-29
ATE120489T1 (de) 1995-04-15
US5661015A (en) 1997-08-26
DE68921923T2 (de) 1995-08-10
NZ229377A (en) 1992-06-25
IE891812L (en) 1989-12-03
DK272889A (da) 1989-12-04
CN1077438C (zh) 2002-01-09
EP0344808A1 (en) 1989-12-06
FI892714A (fi) 1989-12-04
US20030175311A1 (en) 2003-09-18
NO892251L (no) 1989-12-04
HUT52963A (en) 1990-09-28
NO303876B1 (no) 1998-09-14
FI892714A0 (fi) 1989-06-02
IL90489A0 (en) 1990-01-18
FI101453B (fi) 1998-06-30
AU3601689A (en) 1989-12-07
CN1040126C (zh) 1998-10-07
NO892251D0 (no) 1989-06-02
IE67544B1 (en) 1996-04-17
HU212505B (en) 1996-07-29
CN1038837A (zh) 1990-01-17

Similar Documents

Publication Publication Date Title
YU47880B (sh) Protein i postupak za dobijanje proteina
CA2180425A1 (en) Purified primate ctla-8 antigens and related reagents
CA2406240C (en) Hcv anti-core monoclonal antibodies
ES8706964A1 (es) Un procedimiento para fraccionar anticuerpos de suero.
DE60039596D1 (de) Verfahren zur herstellung von monoklonalen antikörpern
AU1273695A (en) Monoclonal antibodies specific for phf-tau, hybridomas secreting them, antigen recognition by these antibodies and their applications
HUP9802401A2 (hu) Az emberi gp39-protein különböző epitópjaira specifikus monoklonális antitestek, valamint eljárások az ilyen antitestek diagnosztikai és terápiás alkalmazására
HUP0202796A2 (en) Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
JPWO2021181994A5 (sh)
PT100637A (pt) Receptor ctla4 e metodos para a sua utilizacao
PT97159A (pt) Processo para a preparacao de uma proteina do antigenio de superficie da hepatite b ou de um seu fragmento e processo para a preparacao de uma vacina
CA2399790A1 (en) Cd40 ligand adjuvant for respiratory syncytial virus
WO2020132091A3 (en) Antibodies that neutralize hepatitis b virus and uses thereof
HUP0103650A2 (hu) Vírusburok-proteinek epitópjai és az ellenük termelt ellenanyagok alkalmazása HCV-vírusantigén gazdaszövetből történő kimutatására
Jemmerson et al. Mapping antigenic sites on proteins: Implications for the design of synthetic vaccines.
DE69531311D1 (de) Monoklonale antikörper spezifisch für endprodukte der fortgeschrittenen glycosylation in biologischen proben
ES8404186A1 (es) "un procedimiento para obtener al menos un polipeptido que presenta la antigenicidad de los antigenos e del virus de la hepatitis b".
CN105229036A (zh) 在疏水性相互作用位点内引入了静电相互作用的蛋白及其制备方法
DK430583D0 (da) Polypeptider samt deres fremstilling og anvendelse
ATE298798T1 (de) Fusionsproteine zwischen antigene aminosäuresequenzen und beta - 2- mikroglobulin
WO1996021734A3 (en) P15 and tyrosinase melanoma antigens and their use in diagnostic and therapeutic methods
WO1999013907A3 (en) Methods to improve immunogenicity of antigens and specificity of antibodies
ATE101345T1 (de) Selektive entfernung von immunkomplexen.
RU2004108115A (ru) Рекомбинантные антитела и композиции, а также способы их создания и использования
DE69737323D1 (de) Adhesin aus heliobacter pylori, welches an blutgruppenantigene bindet