KR910000183A - 재조합 포자충증 백신 - Google Patents

재조합 포자충증 백신 Download PDF

Info

Publication number
KR910000183A
KR910000183A KR1019890007661A KR890007661A KR910000183A KR 910000183 A KR910000183 A KR 910000183A KR 1019890007661 A KR1019890007661 A KR 1019890007661A KR 890007661 A KR890007661 A KR 890007661A KR 910000183 A KR910000183 A KR 910000183A
Authority
KR
South Korea
Prior art keywords
protein
recombinant vector
dna sequence
host organism
vaccine
Prior art date
Application number
KR1019890007661A
Other languages
English (en)
Other versions
KR0156545B1 (ko
Inventor
알텐브르거 베르너
빙거 매리-헬렌
안토니 치조니트 리차드
앨랜 크레이머 리차드
토마스 로메디코 피터
제이. 맥앤드류 스테펜
Original Assignee
쟝-작끄 오가이
에프.호프만-라 로슈 앤드 캄파니 아크티엔게젤샤프트
프리돌린 클라우스너
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쟝-작끄 오가이, 에프.호프만-라 로슈 앤드 캄파니 아크티엔게젤샤프트, 프리돌린 클라우스너 filed Critical 쟝-작끄 오가이
Publication of KR910000183A publication Critical patent/KR910000183A/ko
Application granted granted Critical
Publication of KR0156545B1 publication Critical patent/KR0156545B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/455—Eimeria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

재조합 포자충증 백신
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 에이메리아 테넬라(Eimeria tenella)포자층의 ELISA의 결과를 도시한 것이다.

Claims (30)

  1. 약 28,37,120 또는 200킬로 달톤 이상의 겉보기 분자량을 가지고 아메리칸 타입 컬춰 콜렉션(American Type Culture collection)에 기탁번호 HB 9707 내지 9712로 기탁된 하나 이상의 모노클로날 항체와 특이적으로 결합하는 에이메리아(Eimeria) 표면 항원의 면역반응성 및/또는 항원성 결정소 하나 이상을 갖는 단백질.
  2. 제1항에 있어서, 제15도에 나타낸 아미노산 서열을 갖거나 이의 작용성 등가물인 단백질.
  3. 제1항에 있어서, 제17도에 나타낸 아미노산 서열을 갖거나 이의 작용성 등가물인 단백질.
  4. 제1항에 있어서, 제19도에 나타낸 아미노산 서열을 갖거나 이의 작용성 등가물인 단백질.
  5. 제1항에 있어서, 제21도에 나타낸 아미노산 서열을 갖거나 이의 작용성 등가물인 단백질.
  6. 제1항에 있어서, 5항 중 어느 한 항에 있어서 청구된 단백질을 암호화하는 DNA서열.
  7. 제6항에 있어서, 제14도에 나타낸 뉴클레오 타이드 서열 전체 또는 일부를 함유함을 특징으로 하는 DNA서열.
  8. 제6항에 있어서, 제16도에 나타낸 뉴클레오 타이드 서열 전체 또는 일부를 함유함을 특징으로 하는 DNA서열.
  9. 제6항에 있어서, 제18도에 나타낸 뉴클레오 타이드 서열 전체 또는 일부를 함유함을 특징으로 하는 DNA서열.
  10. 제6항에 있어서, 제20도에 나타낸 뉴클레오 타이드 서열 전체 또는 일부를 함유함을 특징으로 하는 DNA서열.
  11. 제6항 내지 10항 중 어느 한 항에 있어서 청구된 DNA 서열을 함유함을 특징으로 하는 재조합 벡터.
  12. 제11항에 있어서, 재조합 벡터가 적합한 숙주 유기체에서 DNA 서열의 발현을 지시할 수 있는 재조합 벡터.
  13. 제11항 또는 12항에 있어서, 폭스바이러스(poxvirus)벡터인 재조합 백터.
  14. 제11항 또는 12항에 있어서, 이. 콜라이(E.coli)벡터인 재조합 백터.
  15. 제14항에 있어서, PEV /2-4인 재조합 벡터.
  16. 제11항 내지 15항 중 어느 한 항에서 청구된 재조합 벡터로 형질전환된 숙주 유기체.
  17. 제16항에 있어서, 재조합 벡터내에 함유된 제1항 내지 5항중 어느 한 항에 따른 단백질의 암호와 DNA서열을 발현할 수 있는 형질전환된 숙주 유기체.
  18. 제1항 내지 5항 중 어느 한 항에서 청구된 단백질에 대한 항체.
  19. 제18항에 있어서, 모노클로날 항체인 항체.
  20. 제19항에 있어서, ATCC HB 9707, HB 9708, HB 9709, HB 9710, HB9711 및 HB 9712로 이루어진 그룹중에서 선택되는 모노클로날 항체.
  21. 제1 내지 5항에 있어서, 포자충증에 대한 가금의 면역화를 위한 단백질.
  22. (a) 제1항 내지 5항 중 어느 한 항에서 청구된 단백질을 암호화하는 DNA서열을 함유하는 재조합 벡터로 형질전환된 숙주 유기체를 DNA 서열이 발현되는 조건하에서 배양하고, (b) 배양물로부터 단백질을 분리함을 특징으로 하는, 제1항 내지 5항 중 어느 한 항에서 청구된 단백질의 제조방법.
  23. 공지된 방법을 사용하여 제11항 내지 15항 중 어느 한 항에서 청구된 재조합 벡터로 숙주 유기체를 형질전환시킴을 특징으로 하는, 제16항 또는 17항에서 청구된 형질 전환된 숙주 유기체의 제조방법.
  24. 제1항 내지 5항 중 어느 한 항에 따른 단백질 하나 이상 및 생리학적으로 허용되는 담체를 함유함을 특징으로 하는, 포자충증에 대해 가금을 보호하기 위한 백신.
  25. 제13항에 따른 재조합 폭스바이러스 벡터를 함유함을 특징으로 하는, 포자충증에 대해 가금을 보호하기 위한 백신.
  26. 포자충증에 대해 가금을 보호할 수 있는 백신의 제조를 위한 제1항 내지 5항 중 어느 한 항에 따른 단백질의 용도.
  27. 제1항 내지 5항 중 어느 한 항에 있어서, 제22항에서 청구된 방법에 의해 제조되는 단백질.
  28. 제16항 또는 17항에 있어서, 제23항에서 청구된 방법에 의해 제조되는 형질전환된 숙주 유기체.
  29. 상기에 설명한 것과 같은 발명.
  30. 포자충증에 약한 어린 가축에 제24항 또는 25항에서 청구된 백신의 유효량을 투여함을 특징으로 하여, 포자충증에 대해 가금을 보호하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890007661A 1988-06-03 1989-06-03 재조합 포자충증 백신 KR0156545B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20272188A 1988-06-03 1988-06-03
US202,721 1988-06-03
US202721 1988-06-03

Publications (2)

Publication Number Publication Date
KR910000183A true KR910000183A (ko) 1991-01-29
KR0156545B1 KR0156545B1 (ko) 1998-11-16

Family

ID=22750986

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890007661A KR0156545B1 (ko) 1988-06-03 1989-06-03 재조합 포자충증 백신

Country Status (22)

Country Link
US (2) US5661015A (ko)
EP (1) EP0344808B1 (ko)
JP (1) JP3051130B2 (ko)
KR (1) KR0156545B1 (ko)
CN (3) CN1040126C (ko)
AR (1) AR241942A1 (ko)
AT (1) ATE120489T1 (ko)
AU (1) AU635704B2 (ko)
CA (1) CA1340538C (ko)
DE (1) DE68921923T2 (ko)
DK (1) DK272889A (ko)
ES (1) ES2070866T3 (ko)
FI (1) FI101453B (ko)
HU (1) HU212505B (ko)
IE (1) IE67544B1 (ko)
IL (1) IL90489A0 (ko)
MC (1) MC2039A1 (ko)
NO (1) NO303876B1 (ko)
NZ (1) NZ229377A (ko)
PT (1) PT90727B (ko)
YU (1) YU47880B (ko)
ZA (1) ZA893740B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100490669B1 (ko) * 2001-08-30 2005-05-19 (주)아비코아생명공학연구소 조류 콕시듐증을 유발하는 에이메리아 종의 포자소체 표면항원에 대한 ｓｃＦｖ 재조합 항체

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5174993A (en) * 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US5279960A (en) * 1984-07-05 1994-01-18 Enzon Corp. 25 KD coccidial antigen of eimeria tenella
US5273901A (en) * 1984-07-05 1993-12-28 Enzon Corp. Genetically engineered coccidiosis sporozoite 21.5 Kb antigen, ac-6b
US5824656A (en) * 1988-01-15 1998-10-20 Merck & Co., Inc. Recombinant and native group B eimeria tenella immunogens useful as coccidiosis vaccines
DE68927350T2 (de) * 1988-07-05 1997-04-24 British Tech Group Usa Gentechnologisch hergestellter coccidiose-impfstoff
ZA902147B (en) * 1989-03-28 1990-12-28 Akzo Nv Coccidiosis vaccine
ATE94208T1 (de) * 1989-06-21 1993-09-15 Akzo Nv Eimeria tenella-vakzin.
ZA9010461B (en) * 1990-01-26 1991-10-30 Hoffmann La Roche Recombinant coccidiosis vaccines-5-7 eimeria surface antigen
JPH07500483A (ja) * 1991-03-14 1995-01-19 ブリティッシュ・テクノロジー・グループ・ユーエスエイ・インコーポレーテッド 組換え体抗コクシジアワクチン
US6008342A (en) * 1991-07-12 1999-12-28 Roche Vitamins Inc. DNA encoding eimeria antigen
US5403581A (en) * 1991-07-12 1995-04-04 Hoffmann-La Roche Inc. Coccidiosis vaccines
JP3534774B2 (ja) 1995-06-07 2004-06-07 ファイザー・インク コクシジウム症に対する卵内予防接種
US6500438B2 (en) 1995-06-07 2002-12-31 Pfizer Incorporated In ovo vaccination against coccidiosis
ES2253746T3 (es) * 1995-07-03 2006-06-01 Akzo Nobel N.V. Vacuna contra la coccidiosis aviar.
AU2590997A (en) * 1996-03-29 1997-10-22 Life Technologies, Inc. Method for increasing viability and transformation efficiency of bacteria during storage at low temperatures
US6632923B1 (en) * 1996-11-27 2003-10-14 Boston Heart Foundation, Inc. Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
US6627205B2 (en) 1997-12-01 2003-09-30 Pfizer Incorporated Ovo vaccination against coccidiosis
US6984378B1 (en) 1999-02-26 2006-01-10 Pfizer, Inc. Method for the purification, recovery, and sporulation of cysts and oocysts
ZA200400479B (en) * 2001-07-06 2006-05-31 Abic Biolog Lab Teva Nucleic acids encoding recombinant 56 a 82 KDA antigens from gametocytes of Eimeria maxima and their use
WO2003020917A1 (en) 2001-08-30 2003-03-13 Embrex, Inc. Improved methods for producing oocysts
JP3995541B2 (ja) * 2002-06-28 2007-10-24 株式会社ゲン・コーポレーション 抗鶏コクシジウム症組成物
DE10330235A1 (de) * 2003-07-04 2005-01-20 Bayer Healthcare Ag Neues Eimeria Gen und Protein sowie deren Verwendung
US7348401B2 (en) * 2003-09-10 2008-03-25 Innate Biotech, Inc. Peptides that inhibit complement activation
DE602005021873D1 (de) * 2004-03-12 2010-07-29 Univ Georgia Neues impfstoffadjuvans und dessen herstellung und verwendung
US7087425B2 (en) * 2004-03-31 2006-08-08 Embrex, Inc. Method of purifying oocysts using enzymatic digestion of fecal debris
US20110078828A1 (en) * 2004-09-10 2011-03-31 Guardian Biotechnologies Inc. Multi epitope vaccine for poultry
DE602005003429T2 (de) * 2004-12-01 2008-10-02 Zeon Corp. Kodierende DNS für ein Eimeria Apical Membran Antigen 1 und dessen Verwendungen
CN100398156C (zh) * 2005-11-23 2008-07-02 南京农业大学 用于预防鸡球虫病的免疫调节型dna疫苗
US20080194006A1 (en) * 2007-02-08 2008-08-14 Embrex, Inc. Methods of releasing sporocysts from oocysts using controlled shear forces
US11701683B2 (en) 2010-12-22 2023-07-18 The Procter & Gamble Company Methods for foil stamping parts having asymmetrical edges
US10758601B2 (en) 2016-12-22 2020-09-01 Intervet Inc. Eimeria vaccine with improved efficacy
WO2020243240A1 (en) * 2019-05-28 2020-12-03 Case Western Reserve University Compositions and methods for preserving dna methylation

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237224A (en) 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
DE2814039C3 (de) 1978-03-31 1981-02-19 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von Hybrid-Bakterien
EP0135073A3 (en) * 1983-08-19 1987-05-27 American Cyanamid Company Antigens and monoclonal antibodies reactive against merozites of eimeria spp.
US4650676A (en) 1983-08-19 1987-03-17 American Cyanamid Company Antigens and monoclonal antibodies reactive against merozoites of Eimeria spp.
US4710377A (en) * 1983-08-19 1987-12-01 American Cyanamid Company Antigens and monoclonal antibodies reactive against sporozoites of Eimeria spp.
EP0135712A3 (en) * 1983-08-19 1987-05-27 American Cyanamid Company Antigens and monoclonal antibodies reactive against sporozoites of eimeria spp.
US4874705A (en) * 1985-05-16 1989-10-17 Solvay & Cie, S.A. DNA encoding an antigenic protein derived from Eimeria tenella and vaccines for prevention of coccidiosis caused by Eimeria tenella
US5187080A (en) * 1984-06-05 1993-02-16 Solvay & Cie S.A. DNA encoding an antigenic protein derived from Eimeria tenella and vaccines for prevention of coccidiosis caused by Eimeria tenella
CA1340520C (en) * 1984-06-05 1999-05-04 Karel Z. Newman Jr. Antigenic proteins and vaccines containing them and protective antibodies directed to them for prevention of coccidiosis caused by eimeria tenella and eimeria necatrix
US4639372A (en) 1984-06-29 1987-01-27 Merck & Co., Inc. Coccidiosis vaccine
WO1986000528A1 (en) * 1984-07-05 1986-01-30 Genex Corporation Cloned gene and method for making and using the same
US5273901A (en) * 1984-07-05 1993-12-28 Enzon Corp. Genetically engineered coccidiosis sporozoite 21.5 Kb antigen, ac-6b
ES2109254T3 (es) * 1985-12-03 1998-01-16 Dimminaco Ag Sa Ltd Proteinas antigenas y vacunas que las contienen para la prevencion de cocidiosis.
EP0241139A3 (en) * 1986-03-13 1989-04-19 Merck & Co. Inc. Anti-idiotypic vaccine for coccidiosis
US5496550A (en) * 1986-08-14 1996-03-05 Chilwalner Method of reducing the output of Eimeria oocysts from a newborn chick
ATE145245T1 (de) * 1987-03-06 1996-11-15 Amgen Boulder Inc Polypeptide zur verwendung bei der diagnose von kokkidien-infektion und rekombinant-dns, verfahren zur herstellung derselben
EP0315073A2 (en) * 1987-11-02 1989-05-10 Matsushita Electric Industrial Co., Ltd. A composition for pattern forming materials
NZ227595A (en) * 1988-01-15 1991-11-26 Merck & Co Inc Recombinant production of eimeria tenella antigens and their use
NZ227597A (en) * 1988-01-15 1991-11-26 Merck & Co Inc Eimeria tenella group b immunogens and their production
AU620366B2 (en) * 1988-02-12 1992-02-20 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Cloned genes coding for avian coccidiosis antigens which induce a cell-mediated response and method of producing the same
DE3926461A1 (de) * 1989-07-15 1991-01-24 Suttner Gmbh & Co Kg Ventilpistole, insbesondere fuer ein hochdruckreinigungsgeraet

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100490669B1 (ko) * 2001-08-30 2005-05-19 (주)아비코아생명공학연구소 조류 콕시듐증을 유발하는 에이메리아 종의 포자소체 표면항원에 대한 ｓｃＦｖ 재조합 항체

Also Published As

Publication number Publication date
CA1340538C (en) 1999-05-11
CN1076204C (zh) 2001-12-19
FI101453B1 (fi) 1998-06-30
PT90727A (pt) 1989-12-29
CN1186695A (zh) 1998-07-08
CN1187368A (zh) 1998-07-15
MC2039A1 (fr) 1990-05-30
ZA893740B (en) 1990-02-28
KR0156545B1 (ko) 1998-11-16
DE68921923D1 (de) 1995-05-04
JP3051130B2 (ja) 2000-06-12
PT90727B (pt) 1994-11-30
YU113889A (en) 1991-10-31
AU635704B2 (en) 1993-04-01
JPH037594A (ja) 1991-01-14
DK272889D0 (da) 1989-06-02
ES2070866T3 (es) 1995-06-16
AR241942A1 (es) 1993-01-29
EP0344808B1 (en) 1995-03-29
ATE120489T1 (de) 1995-04-15
US5661015A (en) 1997-08-26
DE68921923T2 (de) 1995-08-10
NZ229377A (en) 1992-06-25
IE891812L (en) 1989-12-03
DK272889A (da) 1989-12-04
CN1077438C (zh) 2002-01-09
EP0344808A1 (en) 1989-12-06
FI892714A (fi) 1989-12-04
US20030175311A1 (en) 2003-09-18
NO892251L (no) 1989-12-04
HUT52963A (en) 1990-09-28
NO303876B1 (no) 1998-09-14
FI892714A0 (fi) 1989-06-02
IL90489A0 (en) 1990-01-18
FI101453B (fi) 1998-06-30
AU3601689A (en) 1989-12-07
CN1040126C (zh) 1998-10-07
YU47880B (sh) 1996-05-20
NO892251D0 (no) 1989-06-02
IE67544B1 (en) 1996-04-17
HU212505B (en) 1996-07-29
CN1038837A (zh) 1990-01-17

Similar Documents

Publication Publication Date Title
KR910000183A (ko) 재조합 포자충증 백신
Wright et al. The development of a recombinant Babesia vaccine
RU2432364C2 (ru) ПОЛИКЛОНАЛЬНОЕ АНТИТЕЛО ПРОТИВ Nogo, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ПРИМЕНЕНИЕ АНТИТЕЛА ДЛЯ ИЗГОТОВЛЕНИЯ ЛЕКАРСТВЕННОГО СРЕДСТВА
AU585512B2 (en) Antigenic proteins and vaccines containing them and protective antibodies directed to them for prevention of coccidiosis caused by eimeria tenella and eimeria necatrix
SK56394A3 (en) Anti-vaccine of streptococcus suis infection and method of its production
Schaefer et al. Characterization and formulation of multiple epitope-specific neutralizing monoclonal antibodies for passive immunization against cryptosporidiosis
US20150293118A1 (en) Cross-reactive determinants and methods for their identification
KR900013983A (ko) 콕시디오시스 왁찐
Nelson et al. Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products
Fernandez et al. Protective effect against Rhodococcus equi infection in mice of IgG purified from horses vaccinated with virulence associated protein (VapA)-enriched antigens
EP0603406B1 (en) Fowl mycoplasma antigen, gene thereof, recombinant vector containing said gene, and vaccine prepared by utilizing the same
CA2180309A1 (en) Coccidiosis poultry vaccine
Seed Trypanosoma gambiense and T. equiperdum: Characterization of variant specific antigens
Srivastava et al. Specificity and inhibitory activity of antibodies to Plasmodium falciparum aldolase.
US7279167B2 (en) Infectious Salmon Anaemia virus vaccine
US6203801B1 (en) Coccidiosis polypeptide and vaccines
Mahoney et al. Immunization against babesiosis: current studies and future outlook
WO1995020658A3 (en) Diagnosis and treatment of infections due to streptococci and enterococci
KR930703445A (ko) 톡소플라스마 곤디(toxoplasma gondii)의 단백질 항원의 클로닝 및 발현
Takagi et al. Purification of hemagglutinin from Haemophilus paragallinarum using monoclonal antibody
US20020006408A1 (en) Vaccines against eimeria mediated disorder
US6680061B1 (en) Coccidiosis vaccines
CN104450626B (zh) 抗chMDA5蛋白单克隆抗体及其制备方法和应用
EP0872486A1 (en) Eimeria proteins as vaccines
ZA906667B (en) Antigens and polypeptides derived from babesia(12d3 antigen)

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20070102

Year of fee payment: 9

LAPS Lapse due to unpaid annual fee