ES8706964A1 - Un procedimiento para fraccionar anticuerpos de suero. - Google Patents

Un procedimiento para fraccionar anticuerpos de suero.

Info

Publication number
ES8706964A1
ES8706964A1 ES528001A ES528001A ES8706964A1 ES 8706964 A1 ES8706964 A1 ES 8706964A1 ES 528001 A ES528001 A ES 528001A ES 528001 A ES528001 A ES 528001A ES 8706964 A1 ES8706964 A1 ES 8706964A1
Authority
ES
Spain
Prior art keywords
monoclonal antibodies
affinity purification
antibodies
antigens
environment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528001A
Other languages
English (en)
Other versions
ES528001A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hybritech Inc
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of ES8706964A1 publication Critical patent/ES8706964A1/es
Publication of ES528001A0 publication Critical patent/ES528001A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies

Abstract

PROCEDIMIENTO PARA FRACCIONAR ANTICUERPOS DE SUERO. COMPRENDE: A) INMOVILIZAR EL ANTIGENO SOBRE UN SOPORTE SOLIDO; B) PONER EN CONTACTO EL ANTIGENO CON LOS ANTICUERPOS DEL SUERO EN EL PRIMER MEDIO AMBIENTE, CONSISTENTE EN UN LIQUIDO A UN PH DETERMINADO, PARA FIJAR LOS ANTICUERPOS AL ANTIGENO; Y C) ELUIR UNA FRACCION DE LOS ANTICUERPOS DE LA ETAPA B) EN UN SEGUNDO MEDIO AMBIENTE CONSISTENTE EN UNA SOLUCION CON AGENTES CAOTROPICOS COMO BRK, IK Y GUANIDINA Y CON UN PH ENTRE 4 Y 10,5, PARA OBTENER UNA FRACCION QUE TENGA GRAN AFINIDAD POR UN ANTIGENO EN UN PRIMER MEDIO AMBIENTE Y UNA BAJA AFINIDAD POR EL ANTIGENO EN UN SEGUNDO MEDIO AMBIENTE.
ES528001A 1982-04-12 1983-12-13 Un procedimiento para fraccionar anticuerpos de suero. Expired ES8706964A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36778182A 1982-04-12 1982-04-12

Publications (2)

Publication Number Publication Date
ES8706964A1 true ES8706964A1 (es) 1987-07-01
ES528001A0 ES528001A0 (es) 1987-07-01

Family

ID=23448565

Family Applications (3)

Application Number Title Priority Date Filing Date
ES521371A Expired ES8404858A1 (es) 1982-04-12 1983-04-11 Un procedimiento para la purificacion de un anticuerpo.
ES528001A Expired ES8706964A1 (es) 1982-04-12 1983-12-13 Un procedimiento para fraccionar anticuerpos de suero.
ES528000A Expired ES8506902A1 (es) 1982-04-12 1983-12-13 Un procedimiento para la purificacion de un antigeno.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES521371A Expired ES8404858A1 (es) 1982-04-12 1983-04-11 Un procedimiento para la purificacion de un anticuerpo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES528000A Expired ES8506902A1 (es) 1982-04-12 1983-12-13 Un procedimiento para la purificacion de un antigeno.

Country Status (11)

Country Link
EP (1) EP0105359A4 (es)
AT (1) AT393386B (es)
AU (1) AU622099B2 (es)
CA (1) CA1209907A (es)
CH (1) CH672028A5 (es)
DK (1) DK192191A (es)
ES (3) ES8404858A1 (es)
FI (1) FI88403C (es)
GB (1) GB2128630B (es)
IT (1) IT1219779B (es)
WO (1) WO1983003678A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328918D0 (en) * 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
GB8331071D0 (en) * 1983-11-22 1983-12-29 Karayiannis P Assay for dna/rna
US4666865A (en) * 1984-01-13 1987-05-19 Centocor, Inc. Immunoassay for biologically active human interferon-gamma employing unique monoclonal antibodies
US4789631A (en) * 1984-02-17 1988-12-06 Synbiotics Corporation Immunoassay for anti-dirofilaria immitis antibody
GB8426468D0 (en) * 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
AU5259786A (en) * 1985-01-30 1986-08-07 United States Of America, The Monoclonal antibodies against chlamydial genes specific lipopolysaccharide
US4859611A (en) * 1985-02-28 1989-08-22 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
US4818687A (en) * 1985-02-28 1989-04-04 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
IL75828A (en) * 1985-07-17 1991-06-10 Univ Ramot Immobilization by biologically active proteins
NZ218336A (en) * 1985-12-09 1991-08-27 Kirin Amgen Inc Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf)
US5175255A (en) * 1987-03-23 1992-12-29 Amgen Inc. Methods for purification of platelet-derived growth factor
US5190859A (en) * 1987-02-26 1993-03-02 Dana-Farber Cancer Institute, Inc. Purification of LFA-3
SE468653B (sv) * 1987-03-06 1993-02-22 Perstorp Biolytica Adsorbent foer isokratisk affinitetskromatografi
JPS6463599A (en) * 1987-05-01 1989-03-09 Xoma Corp Purification of immunoglobulin by selective anti-idiotype bond
DE3871799D1 (de) * 1987-07-14 1992-07-09 Univ Manchester Verfahren zur diagnose von infektionen, bei welchem lipopolyscaccharidantigene bestimmt werden.
CA1323567C (en) * 1987-10-05 1993-10-26 Gene R. Nathans Method for purification of antibodies
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
EP0941345A2 (en) * 1996-09-20 1999-09-15 The General Hospital Corporation Chimeric, humanized and single chain antibodies to alpha-2-antiplasmin
EP4238993A3 (en) * 2008-04-11 2023-11-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
SG190727A1 (en) 2010-11-30 2013-07-31 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
KR102147548B1 (ko) 2011-02-25 2020-08-24 추가이 세이야쿠 가부시키가이샤 ＦｃγＲＩＩｂ 특이적 Ｆｃ 항체
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
EP3517550A1 (en) 2011-11-30 2019-07-31 Chugai Seiyaku Kabushiki Kaisha Drug containing carrier into cell for forming immune complex
TWI808330B (zh) 2014-12-19 2023-07-11 日商中外製藥股份有限公司 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法
SG11201607165YA (en) 2014-12-19 2016-09-29 Chugai Pharmaceutical Co Ltd Anti-c5 antibodies and methods of use
EP3394098A4 (en) 2015-12-25 2019-11-13 Chugai Seiyaku Kabushiki Kaisha ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE
EP3494991A4 (en) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATING TO IL-8
JP7191833B2 (ja) 2017-01-30 2022-12-19 中外製薬株式会社 抗スクレロスチン抗体およびその使用
CN110724204B (zh) * 2019-11-18 2021-10-22 广东菲鹏制药股份有限公司 Fc融合蛋白的纯化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172124A (en) * 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
AU558931B2 (en) * 1981-02-26 1987-02-12 Unilever Plc A process and apparatus for the recovery of immunoglobulins
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies

Also Published As

Publication number Publication date
ES521371A0 (es) 1984-05-16
DK192191D0 (da) 1991-11-26
ES528000A0 (es) 1985-08-01
EP0105359A4 (en) 1984-08-20
ATA901983A (de) 1991-03-15
IT1219779B (it) 1990-05-24
GB8332644D0 (en) 1984-01-11
FI834530A (fi) 1983-12-09
FI834530A0 (fi) 1983-12-09
CA1209907A (en) 1986-08-19
AU7256987A (en) 1987-09-03
IT8320550A0 (it) 1983-04-12
EP0105359A1 (en) 1984-04-18
WO1983003678A1 (en) 1983-10-27
GB2128630A (en) 1984-05-02
DK192191A (da) 1991-11-26
GB2128630B (en) 1986-08-28
ES8404858A1 (es) 1984-05-16
FI88403C (fi) 1993-05-10
CH672028A5 (es) 1989-10-13
ES528001A0 (es) 1987-07-01
AU622099B2 (en) 1992-04-02
ES8506902A1 (es) 1985-08-01
FI88403B (fi) 1993-01-29
AT393386B (de) 1991-10-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971201