YU45726B - Postupak za dobijanje novih supstituisanih benzamida - Google Patents

Postupak za dobijanje novih supstituisanih benzamida

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Publication number
YU45726B
YU45726B YU107085A YU107085A YU45726B YU 45726 B YU45726 B YU 45726B YU 107085 A YU107085 A YU 107085A YU 107085 A YU107085 A YU 107085A YU 45726 B YU45726 B YU 45726B
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YU
Yugoslavia
Prior art keywords
hydrogen
formula
oxygen
atoms
group
Prior art date
Application number
YU107085A
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English (en)
Other versions
YU107085A (en
Inventor
I. Monkovic
D. Willner
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Publication of YU107085A publication Critical patent/YU107085A/xx
Publication of YU45726B publication Critical patent/YU45726B/sh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/42Oxygen atoms attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18Oxygen atoms
    • C07D263/20Oxygen atoms attached in position 2
    • C07D263/24Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH SUPSTITUISANIH BENZAMIDA formule: u kojoj je R3 vodonik ili, kada su R4 i R5 oba atomi vodonika, R3 moze da bude C1-4 alkoksi; R4 je vodonik, amino ili C1-4 alkoksi; R5 je vodonik, hloro, bromo, fluoro, trifluorometil, C1-4 alkiltio, C1-4 alkansulfinil, C1-4 alkansulfonil, sulfamil ili R6-(CO)-, ili R4 i R5, uzeti zajedno, mogu da predstavljaju -HN-N=N-; R6 je C1-4alkil, C2-4 alkenil ili C2-4alkinil; R1 predstavlja grupu formule: n je ceo broj sa vrednostima od 1 do 4; R7 i R8 su isti ili razliciti i predstavljaju C1-4 alkil, C2-4 alkenil, C2-4alkinil ili grupu formule: R10 je vodonik ili C1-4alkoksi; R17 je vodonik, halogen, C1-4alkil ili C1-4alkoksi; A je kiseonik ili S (O)p; R2 predstavlja grupu formule: X je kiseonik, sumpor ili =NOR16; Z je -(CH2)p-, kiseonik ili S (O)p; B predstavlja piridil ili oksazolidinil; m je 2 ili 3; p je O, 1 ili 2; q je ceo broj sa vrednostima od 0 do 4; r je 2 ili 3; R9 je vodonik ili C1-4alkil; R11, R12, R13, R15 i R16 su isti ili razliciti i predstavljaju vodonik, C1-4alkil, C2-4alkenil, C2-4alkinil, C1-4alkoksi-C1-4alkil, C5-7cikloalkil ili grupu formule: pod uslovom da, kada je R11, R15 ili R16 C2-4 alkenil ili C2-4 alkinil, nezasiceni ugljenikov atom ne mora da bude direktno vezan za atom kiseonika ili azota; R14 je vodonik, halogen, C1-4 alkil, C2-4alkenil, C2-4 alkinil, C5-7cikloalkil, hidroksi, C1-4alkoksi, C2-4alkeniloksi, C1-4alkoksikarbonil-C2-4-alkenil, hidrazino, acetilhidrazino, fenil ili grupa formule: R18 i R19 su isti ili razliciti i predstavljaju vodonik ili C1-4 alkil; R20 i R21 su oba atomi vodonika ili, uzeti zajedno, predstavljaju grupu formule: ili R12 i R13, uzeti zajedno sa ugljenikovim atomom za koji su vezani, obrazuju zasiceni prsten sa 5 do 7 atoma koji po potrebi sadrzi jedan ili vise hetero-atoma odabranih od kiseonika, azota i sumpora; ili R12 i R14, uzeti zajedno sa ugljenikovim atomima za koje su vezani, grade zasiceni ili nezasiceni prsten sa 5 do 7 atoma koji po potrebi sadrzi jedan ili vise hetero-atoma odabranih od kiseonika, azota i sumpora,; ili R14 i R15, uzeti zajedno sa ugljenikovim i kiseonikovim atomima za koje su vezani, grade zasiceni prsten sa 3 do 7 atoma koji sadrzi kiseonik; i njihovih netoksicnih, farmaceutski prihvatljivih soli, hidrata, solvata ili kvaternernih amonijumskih soli, naznacen ti me, sto jedinjenje formule: u kojoj su R1, R3, R4 i R5 kao jsto je definisano gore, reaguje sa jedinjenjem formule: R2-L u kojoj je R2 kao sto je definisano gore a L je odlazeca grupa kao sto je hloro, bromo, metnsulfoniloksi ili p-toluolsulfoniloksi, u prisustvu baze kao sredstvo za vezivanje kiseline, da bi se dobilo zeljeno jedinjenje formule (I) koje se, po potrebi, prevodi u svoju netoksicnu, farmaceutski prihvatljivu so, hidrat, solvat ili kvaternernu amonujumsku so.
YU107085A 1984-06-28 1985-06-20 Postupak za dobijanje novih supstituisanih benzamida YU45726B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62574284A 1984-06-28 1984-06-28
US06/729,513 US4808624A (en) 1984-06-28 1985-05-06 Pharmacologically active substituted benzamides

Publications (2)

Publication Number Publication Date
YU107085A YU107085A (en) 1988-02-29
YU45726B true YU45726B (sh) 1992-07-20

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ID=27090001

Family Applications (1)

Application Number Title Priority Date Filing Date
YU107085A YU45726B (sh) 1984-06-28 1985-06-20 Postupak za dobijanje novih supstituisanih benzamida

Country Status (29)

Country Link
US (1) US4808624A (sh)
KR (1) KR920000270B1 (sh)
AR (1) AR244677A1 (sh)
AT (1) AT394363B (sh)
AU (1) AU592759B2 (sh)
BE (1) BE902760A (sh)
CH (1) CH663954A5 (sh)
CY (1) CY1597A (sh)
DE (1) DE3523076C2 (sh)
DK (1) DK170332B1 (sh)
ES (5) ES8609218A1 (sh)
FI (1) FI83768C (sh)
FR (1) FR2566773B1 (sh)
GB (1) GB2160871B (sh)
GR (1) GR851576B (sh)
HK (1) HK50991A (sh)
HU (1) HU195475B (sh)
IE (1) IE58705B1 (sh)
IL (1) IL75621A (sh)
IT (1) IT1200657B (sh)
LU (1) LU85978A1 (sh)
MY (1) MY102080A (sh)
NL (1) NL8501856A (sh)
NO (1) NO169485C (sh)
NZ (1) NZ212499A (sh)
PT (1) PT80731B (sh)
SE (1) SE502926C2 (sh)
SG (1) SG41691G (sh)
YU (1) YU45726B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH653670A5 (de) * 1983-03-03 1986-01-15 Hoffmann La Roche Benzamid-derivate.
US4820715A (en) * 1984-06-28 1989-04-11 Bristol-Myers Company Anti-emetic quinuclidinyl benzamides
US4772630A (en) * 1984-11-23 1988-09-20 Ciba-Geigy Corp. Benzamides and their salts
US4882356A (en) * 1987-03-10 1989-11-21 Nassar Munir N Stable injectable antiemetic compositions
FI871447A (fi) * 1986-04-07 1987-10-08 Bristol Myers Co Stabila injicerbara antivomitiva kompositioner.
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
FR2618149B1 (fr) * 1987-07-16 1989-09-22 Synthelabo Derives de n-aminoalkyl n-phenyl arylamides, leur preparation et leur application en therapeutique
GB8718346D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa Substituted benzamides
GB8718345D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa N-substituted benzamides
IT1216120B (it) * 1988-03-17 1990-02-22 Poli Ind Chimica Spa Derivati n_cicloalchilaminoetilbenzamidici, loro preparazione e composizioni farmaceutiche che li contengono.
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
US5395832A (en) * 1991-02-15 1995-03-07 Hokuriku Seiyaku Co., Ltd. Benzamide derivatives
CA2074061A1 (en) * 1991-08-26 1993-02-27 Ivo Monkovic Benzamide multidrug resistance reversing agents
US5723103A (en) * 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use
JP3933244B2 (ja) * 1997-04-04 2007-06-20 株式会社資生堂 アルキレンジアミン誘導体及び抗潰瘍剤、抗菌剤
PT2432467T (pt) 2009-05-20 2018-04-04 Inst Nat Sante Rech Med Antagonistas recetores de serotina 5-ht3 para utilização no tratamento de distúrbios vestibulares lesionais
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
KR101641836B1 (ko) 2015-06-25 2016-07-22 (주)유경 세균방지를 위한 복수형 우유냉각장치

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1139272A (fr) * 1954-06-29 1957-06-27 Thomae Gmbh Dr K Perfectionnements apportés aux procédés pour fabriquer des dérivés de l'acide benzoïque
DE1078581B (de) * 1958-03-15 1960-03-31 Riedel De Haeen Ag Verfahren zur Herstellung von 1, 3-Dioxolanyl-(4)-methylaethern von o-Vanillinsaeureamiden
FR1526M (fr) * 1961-07-25 1962-10-15 Ile De France Nouveaux médicaments antiémétiques.
NL281394A (sh) * 1961-07-25
FR1525M (fr) * 1961-07-25 1962-11-16 Ile De France Médicaments antiémétiques nouveaux.
FR1407055A (fr) * 1963-03-05 1965-07-30 Ile De France Nouveau procédé de préparation de benzamides substitués
GB1019781A (sh) * 1963-03-05
GB1047028A (en) * 1963-11-15 1966-11-02 Rech S Et D Applic Scient Et M Improvements in or relating to 5-acetamido-salicylamide derivatives
BE692670A (sh) * 1966-01-22 1967-07-17
CH505852A (de) * 1968-03-21 1971-04-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Benzoxazepinonen
US3891671A (en) * 1968-08-01 1975-06-24 Ile De France N-(2-pyrrolidyl or piperidyl alkyl)-4-hydroxy benzamides
CA988534A (en) * 1969-02-26 1976-05-04 John Krapcho Benzamide derivatives and processes for their manufacture
FR2313935A1 (fr) * 1975-06-10 1977-01-07 Ile De France Nouveaux benzamides substitues, leurs derives et leur procede de preparation
US3966957A (en) * 1972-04-03 1976-06-29 A. H. Robins Company, Incorporated Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides
US3963745A (en) * 1972-04-03 1976-06-15 A. H. Robins Company, Incorporated Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides
FR2277815A1 (fr) * 1972-06-20 1976-02-06 Ile De France Nouveau procede de preparation du n(diethylaminoethyl) 2-methoxy 4-amino 5-chlorobenzamide
FR2281353A1 (fr) * 1972-06-22 1976-03-05 Ile De France Nouveau procede de preparation du n(diethylaminoethyl) 2-methoxy 4-amino 5-chlorobenzamide
JPS4969627A (sh) * 1972-10-31 1974-07-05
JPS5035125A (sh) * 1973-07-24 1975-04-03
FR2243933B1 (sh) * 1973-09-17 1978-06-30 Ile De France
JPS5126840A (en) * 1974-08-26 1976-03-05 Ile De France Nn jiarukiruaminoarukiru 22 arukokishi 44 chikan 55 harobenzuamido no seizoho
GB1574418A (en) * 1976-11-16 1980-09-03 Anphar Sa Piperidine derivatives
DE2721643A1 (de) * 1977-05-13 1978-11-23 Heumann Ludwig & Co Gmbh Verfahren zur herstellung von eckige klammer auf n,n-dialkylamino-alkyl eckige klammer zu -2-alkoxy-5-sulfamoylbenzamiden
US4207327A (en) * 1977-08-19 1980-06-10 A. H. Robins Company, Inc. N-(4-Pyrazolidinyl)benzamides and their amino precursors
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives

Also Published As

Publication number Publication date
NO169485B (no) 1992-03-23
ES8801191A1 (es) 1988-01-01
NL8501856A (nl) 1986-01-16
CY1597A (en) 1992-04-03
DE3523076C2 (de) 1994-09-22
FI852512L (fi) 1985-12-29
ES8705852A1 (es) 1987-05-16
SE8503207L (sv) 1985-12-29
SG41691G (en) 1991-07-26
KR920000270B1 (ko) 1992-01-11
SE502926C2 (sv) 1996-02-19
ES551393A0 (es) 1987-05-16
LU85978A1 (fr) 1986-01-24
MY102080A (en) 1992-03-31
AU592759B2 (en) 1990-01-25
CH663954A5 (de) 1988-01-29
GR851576B (sh) 1985-11-25
PT80731A (en) 1985-10-01
NO852561L (no) 1985-12-30
ES8801192A1 (es) 1988-01-01
US4808624A (en) 1989-02-28
AU4424285A (en) 1986-01-02
ES557364A0 (es) 1988-01-01
FI852512A0 (fi) 1985-06-25
HK50991A (en) 1991-07-12
DK291385A (da) 1985-12-29
SE8503207D0 (sv) 1985-06-27
ATA193185A (de) 1991-09-15
YU107085A (en) 1988-02-29
IE58705B1 (en) 1993-11-03
HUT38897A (en) 1986-07-28
NO169485C (no) 1992-07-01
NZ212499A (en) 1989-11-28
DK291385D0 (da) 1985-06-27
KR860000246A (ko) 1986-01-27
IL75621A (en) 1990-03-19
PT80731B (en) 1987-04-23
ES557365A0 (es) 1988-01-01
IE851623L (en) 1985-12-28
FR2566773A1 (fr) 1986-01-03
ES544527A0 (es) 1986-09-01
HU195475B (en) 1988-05-30
FR2566773B1 (fr) 1989-05-19
DK170332B1 (da) 1995-08-07
ES557076A0 (es) 1987-12-16
AR244677A1 (es) 1993-11-30
GB2160871B (en) 1988-07-27
GB8516320D0 (en) 1985-07-31
DE3523076A1 (de) 1986-01-09
IL75621A0 (en) 1985-10-31
IT1200657B (it) 1989-01-27
ES8801190A1 (es) 1987-12-16
FI83768B (fi) 1991-05-15
AT394363B (de) 1992-03-25
GB2160871A (en) 1986-01-02
IT8521325A0 (it) 1985-06-27
ES8609218A1 (es) 1986-09-01
FI83768C (fi) 1991-08-26
BE902760A (fr) 1985-12-30

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