PT2432467T - Antagonistas recetores de serotina 5-ht3 para utilização no tratamento de distúrbios vestibulares lesionais - Google Patents

Antagonistas recetores de serotina 5-ht3 para utilização no tratamento de distúrbios vestibulares lesionais

Info

Publication number
PT2432467T
PT2432467T PT107230609T PT10723060T PT2432467T PT 2432467 T PT2432467 T PT 2432467T PT 107230609 T PT107230609 T PT 107230609T PT 10723060 T PT10723060 T PT 10723060T PT 2432467 T PT2432467 T PT 2432467T
Authority
PT
Portugal
Prior art keywords
serotonin
treatment
receptor antagonists
vestibular disorders
lesional vestibular
Prior art date
Application number
PT107230609T
Other languages
English (en)
Inventor
Chabbert Christian
Venail Frédéric
Original Assignee
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP09305464.1A external-priority patent/EP2253316B1/en
Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med
Publication of PT2432467T publication Critical patent/PT2432467T/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4747—Quinolines; Isoquinolines spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A—HUMAN NECESSITIES
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT107230609T 2009-05-20 2010-05-20 Antagonistas recetores de serotina 5-ht3 para utilização no tratamento de distúrbios vestibulares lesionais PT2432467T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09305464.1A EP2253316B1 (en) 2009-05-20 2009-05-20 Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
EP09305996 2009-10-21

Publications (1)

Publication Number Publication Date
PT2432467T true PT2432467T (pt) 2018-04-04

Family

ID=42299223

Family Applications (1)

Application Number Title Priority Date Filing Date
PT107230609T PT2432467T (pt) 2009-05-20 2010-05-20 Antagonistas recetores de serotina 5-ht3 para utilização no tratamento de distúrbios vestibulares lesionais

Country Status (18)

Country Link
US (1) US8580730B2 (pt)
EP (1) EP2432467B1 (pt)
JP (2) JP5955767B2 (pt)
KR (1) KR101779991B1 (pt)
CN (1) CN102458400B (pt)
CA (1) CA2761762C (pt)
CY (1) CY1120661T1 (pt)
DK (1) DK2432467T3 (pt)
ES (1) ES2664599T3 (pt)
HR (1) HRP20180531T1 (pt)
HU (1) HUE037300T2 (pt)
IL (1) IL216258A (pt)
LT (1) LT2432467T (pt)
PL (1) PL2432467T3 (pt)
PT (1) PT2432467T (pt)
RU (1) RU2608458C2 (pt)
SI (1) SI2432467T1 (pt)
WO (1) WO2010133663A1 (pt)

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US9566233B2 (en) 2013-11-14 2017-02-14 Insys Development Company, Inc. Ondansetron sublingual spray formulation
WO2016161309A1 (en) 2015-04-01 2016-10-06 Colorado State University Research Foundation Optimized cancer stem cell vaccines
PT3297628T (pt) * 2015-05-18 2021-08-16 Sensorion Azasetron para uso no tratamento de perda auditiva
US10172833B2 (en) 2015-08-11 2019-01-08 Insys Development Company, Inc. Sublingual ondansetron spray
AU2017248618B2 (en) * 2016-04-14 2023-02-09 Sensorion (+)-azasetron for use in the treatment of ear disorders
PL3442537T3 (pl) * 2016-04-14 2024-07-15 Sensorion (+)-azasetron do zastosowania w leczeniu zaburzeń ucha
JP2019210240A (ja) * 2018-06-04 2019-12-12 学校法人慶應義塾 衝動抑制薬のスクリーニング方法、及び衝動抑制薬
KR102514860B1 (ko) 2020-12-01 2023-03-29 한국과학기술연구원 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물
US11986464B2 (en) * 2021-04-30 2024-05-21 University Of Kentucky Research Foundation 5HT3R antagonist for use in treating aneurysms and cardiovascular risk
WO2023190707A1 (ja) * 2022-03-30 2023-10-05 国立大学法人大阪大学 感音難聴の予防または治療用組成物

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JP2015107995A (ja) 2015-06-11
JP5992550B2 (ja) 2016-09-14
EP2432467A1 (en) 2012-03-28
CA2761762A1 (en) 2010-11-25
KR101779991B1 (ko) 2017-09-19
US8580730B2 (en) 2013-11-12
SI2432467T1 (en) 2018-06-29
RU2011151834A (ru) 2013-06-27
RU2608458C2 (ru) 2017-01-18
ES2664599T3 (es) 2018-04-20
JP5955767B2 (ja) 2016-07-20
IL216258A0 (en) 2012-01-31
HRP20180531T1 (hr) 2018-06-01
CA2761762C (en) 2018-09-04
CN102458400A (zh) 2012-05-16
CN102458400B (zh) 2014-10-08
US20120064094A1 (en) 2012-03-15
IL216258A (en) 2017-01-31
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HUE037300T2 (hu) 2018-08-28
WO2010133663A1 (en) 2010-11-25
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