CY1120661T1 - Ανταγωνιστες υποδοχεα 5-ητ3 σεροτονινης για χρηση στη θεραπεια των αλλοιωτικων αιθουσαιων διαταραχων - Google Patents

Ανταγωνιστες υποδοχεα 5-ητ3 σεροτονινης για χρηση στη θεραπεια των αλλοιωτικων αιθουσαιων διαταραχων

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Publication number
CY1120661T1
CY1120661T1 CY181100353T CY181100353T CY1120661T1 CY 1120661 T1 CY1120661 T1 CY 1120661T1 CY 181100353 T CY181100353 T CY 181100353T CY 181100353 T CY181100353 T CY 181100353T CY 1120661 T1 CY1120661 T1 CY 1120661T1
Authority
CY
Cyprus
Prior art keywords
treatment
disorders
competitors
serotonine receptor
hall
Prior art date
Application number
CY181100353T
Other languages
English (en)
Inventor
Christian Chabbert
Frédéric Venail
Original Assignee
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP09305464.1A external-priority patent/EP2253316B1/en
Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med
Publication of CY1120661T1 publication Critical patent/CY1120661T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K9/0012—Galenical forms characterised by the site of application
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  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η εφεύρεση αφορά τους ανταγωνιστές ή αναστολείς υποδοχέα 5-ΗΤ3 σεροτονίνης 5-ΗΤ3 προς χρήση στη θεραπεία μιας αλλοιωτικής αιθουσαίας διαταραχής.
CY181100353T 2009-05-20 2018-03-30 Ανταγωνιστες υποδοχεα 5-ητ3 σεροτονινης για χρηση στη θεραπεια των αλλοιωτικων αιθουσαιων διαταραχων CY1120661T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09305464.1A EP2253316B1 (en) 2009-05-20 2009-05-20 Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
EP09305996 2009-10-21
PCT/EP2010/056953 WO2010133663A1 (en) 2009-05-20 2010-05-20 Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders
EP10723060.9A EP2432467B1 (en) 2009-05-20 2010-05-20 Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders

Publications (1)

Publication Number Publication Date
CY1120661T1 true CY1120661T1 (el) 2019-12-11

Family

ID=42299223

Family Applications (1)

Application Number Title Priority Date Filing Date
CY181100353T CY1120661T1 (el) 2009-05-20 2018-03-30 Ανταγωνιστες υποδοχεα 5-ητ3 σεροτονινης για χρηση στη θεραπεια των αλλοιωτικων αιθουσαιων διαταραχων

Country Status (18)

Country Link
US (1) US8580730B2 (el)
EP (1) EP2432467B1 (el)
JP (2) JP5955767B2 (el)
KR (1) KR101779991B1 (el)
CN (1) CN102458400B (el)
CA (1) CA2761762C (el)
CY (1) CY1120661T1 (el)
DK (1) DK2432467T3 (el)
ES (1) ES2664599T3 (el)
HR (1) HRP20180531T1 (el)
HU (1) HUE037300T2 (el)
IL (1) IL216258A (el)
LT (1) LT2432467T (el)
PL (1) PL2432467T3 (el)
PT (1) PT2432467T (el)
RU (1) RU2608458C2 (el)
SI (1) SI2432467T1 (el)
WO (1) WO2010133663A1 (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2930565A1 (en) * 2013-11-14 2015-05-21 Insys Pharma, Inc. Ondansetron sublingual spray formulation
WO2016161309A1 (en) 2015-04-01 2016-10-06 Colorado State University Research Foundation Optimized cancer stem cell vaccines
ES2882602T3 (es) * 2015-05-18 2021-12-02 Sensorion Azasetrón para usar en el tratamiento de la pérdida auditiva
US10172833B2 (en) 2015-08-11 2019-01-08 Insys Development Company, Inc. Sublingual ondansetron spray
US11612605B2 (en) * 2016-04-14 2023-03-28 Sensorion (+)-azasetron for use in the treatment of ear disorders
WO2017178645A1 (en) 2016-04-14 2017-10-19 Sensorion (+)-azasetron for use in the treatment of ear disorders
JP2019210240A (ja) * 2018-06-04 2019-12-12 学校法人慶應義塾 衝動抑制薬のスクリーニング方法、及び衝動抑制薬
KR102514860B1 (ko) 2020-12-01 2023-03-29 한국과학기술연구원 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물
US11986464B2 (en) * 2021-04-30 2024-05-21 University Of Kentucky Research Foundation 5HT3R antagonist for use in treating aneurysms and cardiovascular risk
WO2023190707A1 (ja) * 2022-03-30 2023-10-05 国立大学法人大阪大学 感音難聴の予防または治療用組成物

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2919292A1 (de) 1979-05-12 1980-11-20 Bayer Ag Substituierte harnstoffe, verfahren zu ihrer herstellung und ihre verwendung als pflanzenbakterizide
GB2100259B (en) 1981-06-13 1984-10-31 Merrell Toraude & Co Treatment of migraine with tropyl benzoate derivatives
NL8202031A (nl) 1982-05-17 1983-12-16 Stork Pmt Inrichting voor het verwijderen der ingewanden van geslacht gevogelte.
FR2531083B1 (fr) 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
FR2529548A1 (fr) 1982-07-02 1984-01-06 Delalande Sa Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
JPS5936675A (ja) 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4695578A (en) 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
NZ210940A (en) 1984-01-25 1989-08-29 Glaxo Group Ltd 1,2,3-trihydro-3-(1h-imidazol-1-ylmethyl)-4h-carbazol-4-one derivatives and pharmaceutical compositions
US4808624A (en) 1984-06-28 1989-02-28 Bristol-Myers Company Pharmacologically active substituted benzamides
DE3687080T2 (de) 1985-04-27 1993-03-25 Beecham Group Plc Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung.
ES2053451T3 (es) 1986-01-07 1994-08-01 Beecham Group Plc Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles.
DK134687A (da) 1986-03-17 1987-09-18 Glaxo Group Ltd Indolderivater
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4772459A (en) 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
US4906755A (en) 1986-11-03 1990-03-06 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds
ZA878096B (en) 1986-11-03 1988-04-26 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one and related compounds
GR871809B (en) 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
ES2059491T3 (es) 1987-06-29 1994-11-16 Duphar Int Res Derivados de indol con anillos condensados.
GB8718345D0 (en) 1987-08-03 1987-09-09 Fordonal Sa N-substituted benzamides
US5360800A (en) 1987-09-03 1994-11-01 Glaxo Group Limited Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
IL87658A (en) 1987-09-03 1994-06-24 Glaxo Group Ltd Tetrahydro-H-) -12-imidazolylmethyl (pyrido-) and azapino- (] B) -4,3 ([indole-1-ointments, their preparation and pharmaceutical preparations containing them
ZA886585B (en) 1987-09-08 1990-05-30 Lilly Co Eli Specific 5-ht,antagonists
IT1231413B (it) 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
CA1304082C (en) 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
GB8808433D0 (en) 1988-04-11 1988-05-11 Merck Sharp & Dohme Therapeutic agents
US4863921A (en) 1988-04-27 1989-09-05 Rorer Pharmaceutical Corporation Dibenzofurancarboxamides and their pharmaceutical compositions and methods
US5017573A (en) 1988-07-29 1991-05-21 Dainippon Pharmaceutical Co., Ltd. Indazole-3-carboxylic acid derivatives
JPH02160786A (ja) 1988-08-02 1990-06-20 Glaxo Group Ltd ラクタム誘導体
US5008272A (en) 1988-08-15 1991-04-16 Glaxo Group Limited Lactam derivatives
EP0381422B1 (en) 1989-02-02 1996-10-23 Yamanouchi Pharmaceutical Co. Ltd. Tetrahydrobenzimidazole derivatives
US4914207A (en) 1989-05-09 1990-04-03 Pfizer Inc. Arylthiazolylimidazoles
US4963689A (en) 1989-05-19 1990-10-16 Pfizer Inc. Heterocyclicguanidines as 5HT3 antagonists
PL166277B1 (pl) 1989-11-28 1995-04-28 Syntex Inc Sposób wytwarzania nowych zwiazków trójpierscieniowych PL PL PL PL
US5225407A (en) 1990-02-22 1993-07-06 Glaxo Group Limited 5-HT3 receptor antagonists for the treatment of autism
US5256665A (en) 1991-05-10 1993-10-26 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. Process for preparing new 2-piperazinylbenzimidazole
AU7707994A (en) 1993-09-30 1995-04-18 Tokyo Tanabe Company Limited Indoline derivative and 5-ht3 receptor antagonist containing the same as active ingredient
GB9423511D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
JP3702318B2 (ja) 1996-02-09 2005-10-05 日本電池株式会社 非水電解質電池用電極及びその電極を用いた非水電解質電池
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US6566131B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of Smad6 expression
US6410323B1 (en) 1999-08-31 2002-06-25 Isis Pharmaceuticals, Inc. Antisense modulation of human Rho family gene expression
US6107091A (en) 1998-12-03 2000-08-22 Isis Pharmaceuticals Inc. Antisense inhibition of G-alpha-16 expression
US5981732A (en) 1998-12-04 1999-11-09 Isis Pharmaceuticals Inc. Antisense modulation of G-alpha-13 expression
US6046321A (en) 1999-04-09 2000-04-04 Isis Pharmaceuticals Inc. Antisense modulation of G-alpha-i1 expression
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
CA2403397A1 (en) 2000-03-16 2001-09-20 Genetica, Inc. Methods and compositions for rna interference
GB0009914D0 (en) * 2000-04-20 2000-06-07 Metris Therapeutics Limited Device
US6365354B1 (en) 2000-07-31 2002-04-02 Isis Pharmaceuticals, Inc. Antisense modulation of lysophospholipase I expression
US6566135B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 6 expression
US20030044356A1 (en) * 2001-04-20 2003-03-06 Jin Auh Composition for nasal solution sprays having effective component of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one)
ATE356623T1 (de) 2002-01-18 2007-04-15 Aryx Therapeutics 5-ht3-rezeptorantagonisten und verwendungsverfahren
GB0213869D0 (en) * 2002-06-17 2002-07-31 Arakis Ltd The treatment of pain
CN1498613A (zh) * 2002-11-07 2004-05-26 北京东方凯恩医药科技有限公司 5－ht3受体拮抗剂鼻粘膜喷雾给药组合物及其用途
MXPA05007379A (es) * 2003-01-13 2006-02-10 Dynogen Pharmaceuticals Inc Metodo para tratar nauseas, vomito, esfuerzo por vomitar o cualquier combinacion de los mismos.
TWI355936B (en) 2003-02-18 2012-01-11 Helsinn Healthcare Sa Uses of palonosetron hydrochloride
US20040204466A1 (en) * 2003-04-14 2004-10-14 Orchid Chemicals And Pharmaceuticals Ltd. Treatment of bronchial asthma using 5-HT3 receptor antagonists
US20070259933A1 (en) 2006-05-04 2007-11-08 Xenoport, Inc. Compositions, dosage forms and methods of treating emesis
US20070265329A1 (en) 2006-05-12 2007-11-15 Devang Shah T Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
WO2009046168A1 (en) * 2007-10-02 2009-04-09 Avaxia Biologics, Inc. Antibody therapy for use in the digestive tract

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WO2010133663A1 (en) 2010-11-25
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IL216258A (en) 2017-01-31
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