YU169190A - Benzoilgvanidini, postupak za njihovo dobijanje, njihova upotreba kao leka, lek koji ih sadrži - Google Patents

Benzoilgvanidini, postupak za njihovo dobijanje, njihova upotreba kao leka, lek koji ih sadrži

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Publication number
YU169190A
YU169190A YU169190A YU169190A YU169190A YU 169190 A YU169190 A YU 169190A YU 169190 A YU169190 A YU 169190A YU 169190 A YU169190 A YU 169190A YU 169190 A YU169190 A YU 169190A
Authority
YU
Yugoslavia
Prior art keywords
equal
alkyl
medicine
benzoylguanidines
obtaining
Prior art date
Application number
YU169190A
Other languages
English (en)
Other versions
YU48468B (sh
Inventor
H.C. Engelert
H.J. Lang
W. Linz
B. Schoelkens
W. Schlz
Original Assignee
Hoechst Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag. filed Critical Hoechst Ag.
Publication of YU169190A publication Critical patent/YU169190A/sh
Priority to HRP-1691/90A priority Critical patent/HRP940702B1/xx
Publication of YU48468B publication Critical patent/YU48468B/sh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/65—N-sulfonylisocyanates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/47—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/42—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Predlagamo benzoilgvanidine s formulo I kjer pomenijo, R(1) ali R(2)R(6)-S(O)n-ali in kjer vsakokrat drugi substituent R(1) ali R(2) pomeni H, F,Cl,Br, J,C1-C4-alkil, C1-C4-alkoksi, fenoksi, ki je nesubstituiran ali nosi enega do tri substituente iz skupine fluora, klora, metila ali metoksi, R(6)-S(O)n ali in kjer stoji R6 za C1-C6-alkil, C5-C7-cikloalkil, ciklopentilmetil, cikloheksilmetil ali za fenil, ki je nesubstituiran ali nosi enega do tri substituente iz skupine fluora, klora, metila ali metoksi, in kjer sta R(7) in R(8) enaka ali različna, in pomenita H, C1-C6-alkil ali stoji R(7) za fenil (CH2)m z m=1 do 4, ali fenil, ki je nesubstituiran ali nosi enega do dva substituenta iz skupine fluora, klora, metila ali metoksi, in kjer R(7) in R(8) lahko tudi stojita skupaj z ravno verižno ali razvejano C4-C7 verigo, pri čemer je veriga dodatno lahko prekinjena s O, S ali NR(9) in stoji R(9) za H ali metil in kjer R(7) in R(8) skupaj z dušikovim atomom na katerega sta vezana lahko pomenita dihidroindol, tetrahidrokinolin ali tetrahidroizokinolinski sistem, in R(3), R(4) in R(5) pomenijo vodik, C1-C2 alkil ali pri čemer lahko tvorita bodisi R(3) in R(4) skupaj (C2-C4)-alkilensko verigo ali R(4) in R(5) skupaj (C4-C7)-alkilensko verigo, in stoji n za nič, 1 ali 2, in njihove farmacevtsko sprejemljive soli, ki so primerni kot antiaritmična zdravila s kardiozaščitno komponento za profilakso infarktna in zdravljenje infarkta, kot tudi za zdravljenje angine pektoris, pri čemer jih lahko uporabimo tudi preventivno.
YU169190A 1989-09-06 1990-09-05 Benzoilguanidini i postupak za njihovo dobijanje YU48468B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HRP-1691/90A HRP940702B1 (en) 1989-09-06 1994-10-19 Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3929582A DE3929582A1 (de) 1989-09-06 1989-09-06 Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament

Publications (2)

Publication Number Publication Date
YU169190A true YU169190A (sh) 1993-05-28
YU48468B YU48468B (sh) 1998-08-14

Family

ID=6388731

Family Applications (1)

Application Number Title Priority Date Filing Date
YU169190A YU48468B (sh) 1989-09-06 1990-09-05 Benzoilguanidini i postupak za njihovo dobijanje

Country Status (32)

Country Link
US (2) US5091394A (sh)
EP (1) EP0416499B1 (sh)
JP (1) JPH07592B2 (sh)
KR (1) KR0159095B1 (sh)
CN (1) CN1049888C (sh)
AT (1) ATE121738T1 (sh)
AU (1) AU631007B2 (sh)
CA (1) CA2024700C (sh)
CY (1) CY2030A (sh)
CZ (1) CZ278318B6 (sh)
DE (2) DE3929582A1 (sh)
DK (1) DK0416499T3 (sh)
ES (1) ES2073487T3 (sh)
FI (1) FI105182B (sh)
HK (1) HK1008843A1 (sh)
HR (1) HRP940702B1 (sh)
HU (1) HU210770B (sh)
IE (1) IE67451B1 (sh)
IL (1) IL95581A (sh)
LT (1) LT3771B (sh)
LV (1) LV10427B (sh)
MA (1) MA21944A1 (sh)
MX (1) MX22240A (sh)
NO (1) NO179371C (sh)
NZ (1) NZ235168A (sh)
PH (1) PH30477A (sh)
PL (1) PL164167B1 (sh)
PT (1) PT95206B (sh)
RU (1) RU1836338C (sh)
SK (1) SK278583B6 (sh)
YU (1) YU48468B (sh)
ZA (1) ZA907062B (sh)

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LT3771B (en) 1996-03-25
DE3929582A1 (de) 1991-03-07
IE67451B1 (en) 1996-04-03
PH30477A (en) 1997-05-28
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KR0159095B1 (ko) 1999-01-15
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HUT55750A (en) 1991-06-28
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MA21944A1 (fr) 1991-04-01
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US5091394A (en) 1992-02-25
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PL286747A1 (en) 1991-09-23
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