YU137891A - Postopek za izdelavo bifenilkarbonitrila - Google Patents
Postopek za izdelavo bifenilkarbonitrilaInfo
- Publication number
- YU137891A YU137891A YU137891A YU137891A YU137891A YU 137891 A YU137891 A YU 137891A YU 137891 A YU137891 A YU 137891A YU 137891 A YU137891 A YU 137891A YU 137891 A YU137891 A YU 137891A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- novel
- preparation
- formula
- certain
- biphenylcarbonitriles
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- WLPATYNQCGVFFH-UHFFFAOYSA-N 2-phenylbenzonitrile Chemical compound N#CC1=CC=CC=C1C1=CC=CC=C1 WLPATYNQCGVFFH-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 102000005862 Angiotensin II Human genes 0.000 abstract 1
- 101800000733 Angiotensin-2 Proteins 0.000 abstract 1
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
- 229950006323 angiotensin ii Drugs 0.000 abstract 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 abstract 1
- 150000001639 boron compounds Chemical class 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
- 229910052759 nickel Inorganic materials 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Glass Compositions (AREA)
- Turning (AREA)
- Electrotherapy Devices (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Air Bags (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909017482A GB9017482D0 (en) | 1990-08-09 | 1990-08-09 | Manufacturing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU137891A true YU137891A (sh) | 1994-06-10 |
Family
ID=10680408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU137891A YU137891A (sh) | 1990-08-09 | 1991-08-09 | Postopek za izdelavo bifenilkarbonitrila |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0470795B2 (OSRAM) |
| JP (1) | JP3001298B2 (OSRAM) |
| KR (1) | KR920004337A (OSRAM) |
| CN (1) | CN1059516A (OSRAM) |
| AT (1) | ATE117672T1 (OSRAM) |
| AU (1) | AU646473B2 (OSRAM) |
| CA (1) | CA2047369A1 (OSRAM) |
| CS (1) | CS241391A3 (OSRAM) |
| DE (1) | DE69106977T3 (OSRAM) |
| ES (1) | ES2067159T3 (OSRAM) |
| FI (1) | FI913640A7 (OSRAM) |
| GB (2) | GB9017482D0 (OSRAM) |
| HU (1) | HU207841B (OSRAM) |
| IL (1) | IL98862A0 (OSRAM) |
| NO (1) | NO174502B (OSRAM) |
| NZ (1) | NZ239026A (OSRAM) |
| PL (1) | PL291370A1 (OSRAM) |
| PT (1) | PT98608A (OSRAM) |
| RU (1) | RU2026285C1 (OSRAM) |
| TW (1) | TW198710B (OSRAM) |
| YU (1) | YU137891A (OSRAM) |
| ZA (1) | ZA915566B (OSRAM) |
| ZW (1) | ZW9591A1 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI903966A7 (fi) * | 1989-08-11 | 1991-02-12 | Ici Plc | Typpiyhdisteitä |
| DE4132632A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Substituierte imidazolyl-propensaeurederivate |
| DE4132633A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Cyclisch substituierte imidazolyl-propensaeurederivate |
| DE4132631A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Imidazolyl-propensaeurederivate |
| US5310928A (en) * | 1991-11-18 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Process for preparing biphenyltetrazole compounds |
| US5206374A (en) * | 1991-11-18 | 1993-04-27 | E. I. Du Pont De Nemours And Company | Process for preparing tetrazolylphenylboronic acid intermediates |
| FR2688507B1 (fr) * | 1992-03-16 | 1994-05-06 | Synthelabo | Derives de l'acide tetrazolylbenzeneboronique, leur preparation et leur utilisation comme intermediaires de synthese. |
| FR2689887B1 (fr) * | 1992-04-13 | 1995-06-23 | Sanofi Elf | Procede de preparation d'un derive de biphenyle. |
| FR2696746B1 (fr) * | 1992-10-12 | 1994-11-18 | Synthelabo | Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse. |
| DE4423061C1 (de) * | 1994-07-01 | 1996-01-18 | Hoechst Ag | Verfahren zur Herstellung von Biphenylen mit Palladacyclen als Katalysatoren |
| DE4426671A1 (de) * | 1994-07-28 | 1996-02-01 | Hoechst Ag | Verfahren zur Kreuzkupplung von aromatischen Borverbindungen mit aromatischen Halogenverbindungen oder Perfluoralkylsulfonaten |
| KR100354802B1 (ko) * | 1994-10-20 | 2002-12-26 | 한국화학연구원 | 테트라졸유도체의제조방법 |
| JP2928982B2 (ja) | 1994-10-27 | 1999-08-03 | 住化ファインケム株式会社 | ４’−ブロモメチル−２−シアノビフェニルの製造法 |
| DE19620023C2 (de) * | 1996-05-17 | 2001-03-08 | Celanese Chem Europe Gmbh | Verfahren zur Herstellung von Phosphinat- oder Phosphonatgruppen enthaltenden tertiären Phosphanen und neue Phosphinatgruppen enthaltende tertiäre Phosphane |
| US6194599B1 (en) | 1997-04-08 | 2001-02-27 | Catalytica, Inc. | Process for preparing biaryl compounds |
| US5922898A (en) * | 1997-04-08 | 1999-07-13 | Catalytica Pharmaceuticals, Inc. | Process for preparing biaryl compounds |
| CA2321791A1 (en) | 1998-03-18 | 1999-09-23 | Ciba Specialty Chemicals Holding Inc. | Coupling reactions with palladium catalysts |
| US6962999B2 (en) | 2001-07-25 | 2005-11-08 | Pharmacore, Inc. | Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles |
| DE10211597A1 (de) * | 2002-03-15 | 2003-10-02 | Merck Patent Gmbh | Verfahren zur Herstellung von Ringverbindungen |
| EP1474417B1 (en) | 2002-04-29 | 2006-03-22 | Teva Pharmaceutical Industries Ltd. | Processes for preparing losartan and losartan potassium |
| PT1535901E (pt) | 2002-06-12 | 2008-04-10 | Sumitomo Chemical Co | Processo para a produção de 4'-bromometil-2-cianobifenilo |
| US7105467B2 (en) | 2003-07-08 | 2006-09-12 | Pharmacore, Inc. | Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives |
| US7105707B2 (en) | 2003-12-17 | 2006-09-12 | Pharmacore, Inc. | Process for preparing alkynyl-substituted aromatic and heterocyclic compounds |
| JP2006151946A (ja) * | 2004-04-30 | 2006-06-15 | Konishi Kagaku Ind Co Ltd | ジアリール誘導体の製造方法 |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| EP2473476B1 (de) * | 2009-08-31 | 2015-01-14 | Bayer Intellectual Property GmbH | Tetraarylborat verfahren zur herstellung von substituierten biphenylen |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| CN105764916B (zh) | 2013-06-05 | 2021-05-18 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| JP5975081B2 (ja) * | 2013-09-30 | 2016-08-23 | ダイキン工業株式会社 | 含フッ素ビアリール化合物の製造方法 |
| JP2025508272A (ja) | 2021-11-02 | 2025-03-24 | フレア・セラピューティクス・インコーポレーテッド | Ｐｐａｒｇ逆アゴニストおよびその使用 |
| CN117623932A (zh) * | 2023-11-30 | 2024-03-01 | 江苏康恒化工有限公司 | 中间体2，2’-二硝基联苯的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| WO1989003821A1 (en) * | 1987-10-19 | 1989-05-05 | The Secretary Of State For Defence In Her Britanni | Laterally cyano- and fluoro-substituted terphenyls |
| CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| FI903966A7 (fi) * | 1989-08-11 | 1991-02-12 | Ici Plc | Typpiyhdisteitä |
-
1990
- 1990-08-09 GB GB909017482A patent/GB9017482D0/en active Pending
-
1991
- 1991-07-15 ZW ZW95/91A patent/ZW9591A1/xx unknown
- 1991-07-16 ZA ZA915566A patent/ZA915566B/xx unknown
- 1991-07-16 IL IL98862A patent/IL98862A0/xx unknown
- 1991-07-16 AU AU80436/91A patent/AU646473B2/en not_active Ceased
- 1991-07-16 GB GB919115244A patent/GB9115244D0/en active Pending
- 1991-07-18 CA CA002047369A patent/CA2047369A1/en not_active Abandoned
- 1991-07-18 NZ NZ239026A patent/NZ239026A/en unknown
- 1991-07-24 HU HU912481A patent/HU207841B/hu not_active IP Right Cessation
- 1991-07-29 CN CN91105206A patent/CN1059516A/zh active Pending
- 1991-07-30 FI FI913640A patent/FI913640A7/fi unknown
- 1991-08-02 CS CS912413A patent/CS241391A3/cs unknown
- 1991-08-05 DE DE69106977T patent/DE69106977T3/de not_active Expired - Fee Related
- 1991-08-05 ES ES91307184T patent/ES2067159T3/es not_active Expired - Lifetime
- 1991-08-05 EP EP91307184A patent/EP0470795B2/en not_active Expired - Lifetime
- 1991-08-05 AT AT91307184T patent/ATE117672T1/de active
- 1991-08-08 NO NO913086A patent/NO174502B/no unknown
- 1991-08-08 PT PT98608A patent/PT98608A/pt not_active Application Discontinuation
- 1991-08-08 RU SU915001352A patent/RU2026285C1/ru active
- 1991-08-08 KR KR1019910013873A patent/KR920004337A/ko not_active Withdrawn
- 1991-08-08 PL PL29137091A patent/PL291370A1/xx unknown
- 1991-08-08 JP JP3199442A patent/JP3001298B2/ja not_active Expired - Fee Related
- 1991-08-09 YU YU137891A patent/YU137891A/sh unknown
- 1991-08-12 TW TW080106352A patent/TW198710B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| FI913640A0 (fi) | 1991-07-30 |
| NO174502C (OSRAM) | 1994-05-18 |
| FI913640A7 (fi) | 1992-02-10 |
| HU912481D0 (en) | 1991-12-30 |
| ATE117672T1 (de) | 1995-02-15 |
| DE69106977D1 (de) | 1995-03-09 |
| RU2026285C1 (ru) | 1995-01-09 |
| AU8043691A (en) | 1992-02-13 |
| DE69106977T2 (de) | 1995-05-24 |
| JPH04253949A (ja) | 1992-09-09 |
| CN1059516A (zh) | 1992-03-18 |
| PT98608A (pt) | 1992-06-30 |
| GB9017482D0 (en) | 1990-09-26 |
| PL291370A1 (en) | 1992-11-16 |
| TW198710B (OSRAM) | 1993-01-21 |
| CS241391A3 (en) | 1992-03-18 |
| NO174502B (no) | 1994-02-07 |
| CA2047369A1 (en) | 1992-02-10 |
| HUT59662A (en) | 1992-06-29 |
| GB9115244D0 (en) | 1991-08-28 |
| HU207841B (en) | 1993-06-28 |
| ZW9591A1 (en) | 1992-06-10 |
| EP0470795B2 (en) | 2001-02-21 |
| ES2067159T3 (es) | 1995-03-16 |
| KR920004337A (ko) | 1992-03-27 |
| IL98862A0 (en) | 1992-07-15 |
| NO913086L (no) | 1992-02-10 |
| NO913086D0 (no) | 1991-08-08 |
| JP3001298B2 (ja) | 2000-01-24 |
| EP0470795B1 (en) | 1995-01-25 |
| NZ239026A (en) | 1993-12-23 |
| EP0470795A1 (en) | 1992-02-12 |
| ZA915566B (en) | 1992-04-29 |
| AU646473B2 (en) | 1994-02-24 |
| DE69106977T3 (de) | 2001-07-19 |
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