WO2016104730A1 - 泡吐出容器入り液体口腔用組成物 - Google Patents
泡吐出容器入り液体口腔用組成物 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Definitions
- the present invention relates to a liquid oral cavity composition containing a foam discharge container.
- the foam composition is directly applied from the discharge port to the oral cavity at the time of use.
- a feeling of use and the like can be brought about.
- various surfactants are used in order to impart desired performance.
- Patent Document 1 in addition to dextranase, a liquid oral preparation containing a nonionic surfactant such as polyoxyethylene hydrogenated castor oil is directly injected into the mouth with a specific foam density, thereby Increases retention in dental plaque.
- Patent Document 2 discloses an oral preparation obtained by filling a container with a liquid oral composition containing an anionic surfactant such as phosphoric monoesters, and the composition is directly foamed. In order to improve usability, etc.
- Patent Documents 3 to 4 disclose a foamy oral composition that is filled in a non-gas atmospheric container containing a specific amount of an anionic surfactant and a nonionic surfactant or an amphoteric surfactant. It is intended to improve dispersibility and foam quality in the oral cavity.
- Patent Document 1 JP 2000-44448 (Patent Document 2) JP 10-167743 (Patent Document 3) JP 8-333226 (Patent Document 4) JP 9-295923 A
- the present invention includes the following components (A), (B) and (C):
- the content of component (a-1) is 1.2% by mass or less Or the component (a-1) is not contained
- the content of the component (a-2) is 0.25% by mass or more and 1.5% by mass or less
- the content of ethanol is 3% by mass or less
- the present invention directly discharges a liquid oral cavity composition containing a foam discharge container from the discharge port provided in the foam discharge container into the oral cavity, and the liquid oral composition containing the foam discharge container via the discharge port is foamed. It is related with the usage method of the liquid oral cavity composition containing the said foam discharge container applied to intraoral.
- Patent Document 1 If only a nonionic surfactant is used as a surfactant as in Patent Document 1, it may be difficult to hold foam well in the oral cavity where saliva also intervenes. Further, as in Patent Document 2, if an anionic surfactant is used and the amount of ethanol is large, it is easy to defoam and clogging may occur in the porous member provided in the foam discharge container. Furthermore, as in Patent Documents 3 to 4, even when an anionic surfactant is combined with a nonionic surfactant or an amphoteric surfactant, the content of these surfactants and the content of other components such as ethanol are factors. When stored at a low temperature, the viscosity increases rapidly, and the dischargeability from the container may decrease, and there is still room for improvement.
- the present invention relates to a liquid oral cavity composition containing a foam discharge container that effectively suppresses an increase in viscosity at a low temperature while maintaining good foam quality and has high storage stability.
- the present inventor has made various studies, and as a surfactant, a specific polyol and water are used while using one or two or more selected from a specific anionic surfactant and an amphoteric surfactant in a limited amount. In combination with a specific amount, and by limiting the content of ethanol, abrasive powder, binder, nonionic surfactant, and specific sugar alcohol, respectively, resulting in good foam quality, after storage at low temperature In addition, it has been found that a liquid oral cavity composition containing a foam discharge container capable of exhibiting excellent storage stability while having an excellent discharge property while suppressing an increase in viscosity can be obtained.
- liquid oral cavity composition containing a foam discharge container of the present invention when applied to the oral cavity in the form of foam from the container, it provides good foam quality even when saliva is present, and exhibits excellent usability It can be used, and even after storage at a low temperature, it can exhibit a high storage stability while maintaining a suitable viscosity and good discharge properties, and also has a good discharge even after storage at a high temperature. Can demonstrate its sexuality. Furthermore, it is possible to promote the adsorptivity of the bactericidal agent in the oral cavity, and the oral environment can be effectively improved.
- the composition for liquid oral cavity containing a foam discharge container of the present invention comprises an anionic surfactant selected from N-acyl amino acid salt, alkyl sulfate ester salt, alkyl phosphate salt, and ⁇ -olefin sulfonate salt as component (A) (A-1) and one or more surfactants selected from amphoteric surfactant (a-2) in a total amount of 0.3% by mass to 2.5% by mass, and a component ( The content of a-1) is 1.2% by mass or less, or the component (a-1) is not contained and the content of the component (a-2) is 0.25% by mass or more and 1.5% by mass or less. It is below mass%.
- anionic surfactant selected from N-acyl amino acid salt, alkyl sulfate ester salt, alkyl phosphate salt, and ⁇ -olefin sulfonate salt
- the component (A) surfactant is composed of N-acyl amino acid salt, alkyl sulfate ester salt, alkyl phosphate salt, and ⁇ -olefin sulfonate salt.
- amphoteric surfactant of component (a-2) is contained in an amount of 0.25% by mass to 1.5% by mass and does not contain the anionic surfactant of component (a-1).
- the anionic surfactant of the component (a-1) when contained in an amount of 1.2% by mass or less, the amphoteric surfactant of the component (a-2) together with the component (a-1) What is necessary is just to contain by 25 to 1.5 mass%.
- the anionic surfactant of the component (a-1) which can provide good foam quality, but easily forms precipitates in a low temperature environment, while containing the surfactant of the component (A) in a limited amount.
- the liquid oral cavity composition in the foam discharge container of the present invention is a composition applied to the oral cavity, unlike skin cleansing agents such as hand soap, face wash, body cleaning agent, hair shampoo and the like.
- the anionic surfactants and amphoteric surfactants the cationic fungicide used as necessary should reduce the harmfulness and irritation, so the content of these surfactants is limited.
- the foam discharged from the container may have an appropriate foam viscosity with good elongation.
- this not only allows the foam to spread smoothly in the oral cavity environment where saliva is present, but also allows the foam to be well maintained even when diluted with saliva due to the viscosity provided by the appropriate foam viscosity.
- the liquid oral cavity composition containing a foam discharge container of the present invention suppresses an increase in the viscosity of the liquid even at a low temperature, the foam viscosity discharged from the container is high, so that good discharge properties can be obtained and the oral cavity can be obtained. It is possible to obtain a good foam quality which spreads in the inside and is excellent in foaminess.
- One or more anionic surfactants selected from N-acyl amino acid salts, alkyl sulfates, alkyl phosphates, and ⁇ -olefin sulfonates of component (a-1) include N-lauroyl Acyl sarcosine salts such as sarcosine salt and N-myristoyl sarcosine salt; N-methyl acyl taurine salts such as N-lauroyl methyl taurine salt and N-myristoyl methyl taurine salt; N such as N-lauroyl taurine salt and N-myristoyl taurine salt N-acyl glutamates such as N-lauroyl glutamate, N-myristoyl glutamate, N-palmitoyl glutamate and N-cocoyl glutamate; alkyl sulfates such as lauryl sulfate and myristyl sulfate; Alkyl phosphates such as lauryl phosphate The number of
- N-lauroylmethyl taurate, N-myristoyl glutamate, and lauryl sulfate are more preferable from the viewpoint of good cutting ability and bactericidal or wettability when applied to the oral cavity.
- These salts are preferably alkali metal salts, more preferably sodium salts and potassium salts, and sodium salts. Preferred. From the viewpoint of foamability, it is preferable that the anionic surfactant of component (a-1) contains at least sodium lauryl sulfate.
- the content of component (a-1) is from the viewpoint of effectively suppressing the generation of precipitates at low temperatures when such component (a-1) is contained, and from the viewpoint of maintaining good foam quality in the oral cavity.
- it is 1.2% by mass or less, preferably 1% by mass or less, more preferably 0.8% by mass or less, and preferably 0%. It is 1% by mass or more, more preferably 0.2% by mass or more, or the component (a-1) is contained without containing the component (a-1) anionic surfactant.
- the content of the component (a-1) is 1.2% by mass or less, preferably 0.1% by mass or more and 1.2% by mass in the liquid oral cavity composition in the foam discharge container of the present invention. % Or less, more preferably 0.2 to 1% by mass, still more preferably 0.2 to 0.8% by mass, or no component (a-1) is contained.
- the liquid oral cavity composition containing a foam discharge container of the present invention preferably contains no fatty acid or salt thereof as an anionic surfactant other than the component (a-1).
- fatty acids or salts thereof include coconut oil fatty acids, myristic acid, lauric acid, palmitic acid, stearic acid, and mixtures thereof, or salts thereof.
- the content of these fatty acids or salts thereof is from the viewpoint of suppressing the increase in viscosity at low temperatures, effectively suppressing the generation of precipitates, and improving the flavor while ensuring the dischargeability from the container.
- liquid oral cavity composition containing a foam discharge container it is preferably 0.2% by mass or less, more preferably 0.1% by mass or less, still more preferably 0.01% by mass or less, and preferably 0%. More preferably, it exceeds the mass% or does not contain a fatty acid or a salt thereof.
- the liquid oral cavity composition in the foam discharge container of the present invention may contain an anionic surfactant other than the component (a-1) and the fatty acid or a salt thereof. From the viewpoint of enhancing the feeling of use by reducing internal irritation and the like, and from the viewpoint of dischargeability from the container, the content is preferably less than the content of component (a-1).
- anionic surfactant other than the component (a-1) and fatty acid or salt thereof examples include sodium dodecylbenzenesulfonate, ⁇ -sulfo fatty acid alkyl ester / sodium, higher fatty acid sulfonated monoglyceride salt, hydrogenated coconut fatty acid monoglyceride mono Examples thereof include sodium sulfate and sodium lauryl sulfoacetate.
- the content of the anionic surfactant is preferably 0.2% by mass or less, more preferably 0.1% by mass in the liquid oral cavity composition in the foam discharge container of the present invention.
- sodium dodecylbenzenesulfonate, ⁇ -sulfo fatty acid alkyl ester / sodium, and higher fatty acid sulfonated monoglyceride salts are preferably not contained.
- Component (a-2) amphoteric surfactants include betaine acetate such as lauryldimethylaminoacetic acid betaine; imidazolinium betaine such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazolium betaine; Alkylsulfobetaines such as laurylsulfobetaine and laurylhydroxysulfobetaine; coconut oil fatty acid amide alkylbetaines such as coconut oil fatty acid amidepropylbetaine; long-chain alkylimidazoline betaine salts such as sodium N-alkyl-1-hydroxyethylimidazoline betaine 1 type, or 2 or more types.
- betaine acetate such as lauryldimethylaminoacetic acid betaine
- imidazolinium betaine such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazolium betaine
- coconut oil fatty acid amide alkylbetaine and alkylsulfobetaine are used.
- coconut oil fatty acid amide alkyl betaine is more preferable
- coconut oil fatty acid amide alkyl betaine having 2 to 5 carbon atoms of alkyl is more preferable
- coconut oil fatty acid amide propyl betaine is further more preferable.
- the content of the component (a-2) is a viewpoint that effectively suppresses the generation of precipitates at a low temperature even when the liquid oral cavity composition in a foam discharge container of the present invention contains the component (a-1). From the viewpoint of maintaining an appropriate viscosity after low-temperature storage, it is 0.25% by mass or more, preferably 0.3% by mass or more in the liquid oral cavity composition containing a foam discharge container of the present invention. More preferably, it is 0.4 mass% or more.
- the content of the component (a-2) is the foam discharge container of the present invention from the viewpoint of preventing the generation of precipitates at low temperatures and ensuring good foam quality and flavor while suppressing the increase in viscosity at low temperatures.
- the composition for entering liquid oral cavity it is 1.5% by mass or less, preferably 1.2% by mass or less, more preferably 1% by mass or less.
- the content of the component (a-2) is 0.25% by mass or more and 1.5% by mass or less, preferably 0.3 to 1.2% by mass, more preferably 0.3 to 1.2% by mass.
- the content is 1% by mass, and more preferably 0.4 to 1% by mass.
- the content of one or more surfactants selected from the component (a-1) and the component (a-2) is good foam quality in the oral cavity where saliva is also present.
- the total amount is 0.3% by mass or more, preferably 0.4% by mass or more, and more preferably 0.5% by mass. % Or more, and more preferably 0.6% by mass or more.
- the content of one or more surfactants selected from component (a-1) and component (a-2) in component (A) is effective for good taste and feeling in the oral cavity.
- the total composition in the liquid oral cavity composition of the present invention is 2.5% by mass or less, preferably 2.2% by mass or less, more preferably 2%. It is at most mass%, more preferably at most 1.7 mass%, even more preferably at most 1.3 mass%.
- the content of one or more surfactants selected from the component (a-1) and the component (a-2) in the component (A) is the composition for liquid oral cavity in the foam discharge container of the present invention.
- the total amount is 0.3% by mass or more and 2.5% by mass or less.
- the total content of the component (A) surfactant is preferably 0.4 to 2.2% by mass, more preferably 0.5 to 2% by mass, The amount is preferably 0.6 to 1.7% by mass, and more preferably 0.6 to 1.3% by mass.
- the mass ratio of the component (a-2) to the component (a-1) ((a-2) / (a- 1)) is preferably 0.5 or more, more preferably 0.55, from the viewpoint of improving low-temperature storage stability while effectively suppressing the generation of precipitates at low temperatures and maintaining an appropriate viscosity. It is above, More preferably, it is 0.6 or more, More preferably, it is 0.65 or more. Further, the mass ratio ((a-2) / (a-1)) of the component (a-2) and the component (a-1) maintains good foam quality, and has excellent dischargeability from the container and foam.
- the mass ratio ((a-2) / (a-1)) of component (a-2) to component (a-1) is preferably 0.5 to 3, more preferably 0.55 to 2.5, more preferably 0.6 to 2, even more preferably 0.65 to 1.8, and even more preferably 0.65 to 1.3.
- the composition for liquid oral cavity containing a foam discharge container of the present invention includes, as component (B), one or more polyols selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol having an average molecular weight of 1000 or less in total. 10 mass% or more and 40 mass% or less are contained. Thereby, good foam quality and excellent storage stability at low temperature can be effectively combined. Especially, it is preferable to use the 1 type (s) or 2 or more types of polyol chosen from glycerol, propylene glycol, and butylene glycol as a component (B).
- the average molecular weight of the polyethylene glycol means a mass average molecular weight measured by GPC (gel permeation chromatography).
- the weight average molecular weight of the polyethylene glycol used as the component (B) is 1000 or less, preferably 850 or less, from the viewpoint of low-temperature storage stability and prevention of clogging of the porous member of the foam discharge container. From a foam quality viewpoint, Preferably it is 200 or more, More preferably, it is 400 or more.
- the content of the component (B) is such that, after low-temperature storage, the liquid oral composition containing the foam discharge container of the present invention is isopropylmethylphenol, etc.
- a total of 10 mass in the liquid oral cavity composition containing the foam discharge container of the present invention is % Or more, preferably 12% by mass or more, and more preferably 15% by mass or more.
- the content of the component (B) is the foam of the present invention from the viewpoint of securing good dischargeability from the container and excellent usability, from the viewpoint of suppressing an increase in viscosity, and from the viewpoint of enhancing low-temperature storage stability.
- the total amount is 40% by mass or less, preferably 37% by mass or less, more preferably 35% by mass or less, and further preferably 32% by mass or less.
- the content of the component (B) is 10 to 40% by mass in total, preferably 12 to 37% by mass in the liquid oral cavity composition in the foam discharge container of the present invention, More preferably, it is 15 to 35% by mass, and still more preferably 15 to 32% by mass.
- the content of polyethylene glycol having an average molecular weight of 1000 or less used as the component (B) is preferably 7% by mass or less, more preferably 5% by mass or less, from the viewpoint of moderate viscosity after low-temperature storage. Preferably it is 3 mass% or less, More preferably, it is 2 mass% or less, and the thing which does not contain polyethyleneglycol may be sufficient.
- the mass ratio ((B) / (A)) of the component (B) and the component (A) is preferably 6 or more from the viewpoint of securing good foamability while ensuring good foam quality. Yes, more preferably 8 or more, still more preferably 10 or more, and even more preferably 12 or more. Moreover, the mass ratio ((B) / (A)) of the component (B) and the component (A) is the viewpoint of achieving both an appropriate viscosity and storage stability after low-temperature storage, and the foam of the present invention as described later.
- the composition for liquid oral cavity containing a discharge container contains a specific bactericidal agent such as isopropylmethylphenol or a specific anti-inflammatory agent, it is preferably 130 or less from the viewpoint of effectively increasing the adsorptivity in the oral cavity. More preferably, it is 90 or less, More preferably, it is 70 or less, More preferably, it is 55 or less, More preferably, it is 52 or less.
- the mass ratio of component (A) to component (B) ((B) / (A)) is preferably 6 to 130, more preferably 8 to 90, and still more preferably 8 to 70. More preferably, it is 10 to 55, and still more preferably 12 to 52.
- the liquid oral cavity composition containing a foam discharge container of the present invention contains 50% by mass or more and 89% by mass or less of water as the component (C).
- the water of component (C) in the present invention includes not only purified water and ion exchange water blended in a liquid oral cavity composition containing a foam discharge container, but also water contained in each blended component. It means the total moisture contained in the composition.
- Content of a component (C) is 50 mass% in the liquid oral cavity composition containing a foam discharge container of this invention from a viewpoint which ensures the outstanding preservation
- the content of the component (C) is such that the liquid foam composition containing the foam discharge container according to the present invention is isopropylmethylphenol or the like, as described later, in view of maintaining good foam quality and dischargeability from the container.
- a bactericidal agent or a specific anti-inflammatory agent in the case of containing a bactericidal agent or a specific anti-inflammatory agent, from the viewpoint of enhancing the adsorptivity in the oral cavity, it is 89% by mass or less in the liquid oral cavity composition containing the foam discharge container of the present invention. Therefore, it is preferably 86% by mass or less, and more preferably 83% by mass or less.
- the content of the component (C) is 50% by mass or more and 89% by mass or less, preferably 55 to 86% by mass, more preferably in the liquid oral cavity composition in the foam discharge container of the present invention. Is from 60 to 83% by mass, more preferably from 65 to 83% by mass.
- the mass ratio of component (A) to component (C) has a sufficiently high foam viscosity, and ensures good foam quality and prevents the occurrence of precipitates at low temperatures. From the viewpoint, it is preferably 0.5 ⁇ 10 ⁇ 2 or more, more preferably 0.6 ⁇ 10 ⁇ 2 or more, still more preferably 0.75 ⁇ 10 ⁇ 2 or more, and still more preferably 0.8. It is 8 ⁇ 10 ⁇ 2 or more. Further, the mass ratio ((A) / (C)) of the component (A) and the component (C) is preferably from the viewpoint of effectively suppressing the increase in viscosity at low temperatures and preventing the generation of precipitates after low temperature storage.
- the mass ratio ((A) / (C)) of component (A) to component (C) is preferably 0.5 ⁇ 10 ⁇ 2 to 5 ⁇ 10 ⁇ 2 , more preferably 0.6 ⁇ . 10 ⁇ 2 to 4.4 ⁇ 10 ⁇ 2 , more preferably 0.75 ⁇ 10 ⁇ 2 to 2.5 ⁇ 10 ⁇ 2 , and still more preferably 0.8 ⁇ 10 ⁇ 2 to 2 ⁇ 10. -2 .
- the liquid oral cavity composition containing a foam discharge container of the present invention is preferably transparent or translucent. Specifically, it is preferable that there is no precipitate, thereby preventing an increase in the pressing force of the foam discharge container, and clogging of the porous member of the foam discharge container can be prevented.
- Transparent in the present invention means that the transmittance of light having an absorption wavelength of 550 nm when a liquid oral composition is filled in a cell having an optical path length of 10 mm is 80% or more. It is preferably 90% or more, and more preferably 95% or more from the viewpoint of higher transparency. A quartz cell is used as the cell.
- the liquid oral cavity composition containing a foam discharge container of the present invention has an ethanol content of 3% by mass or less.
- the content of ethanol is 3% by mass or less in the liquid oral cavity composition containing the foam discharge container of the present invention, from the viewpoint of effectively enhancing the storage stability at low temperatures and ensuring good discharge properties.
- the liquid oral cavity composition containing a foam discharge container of the present invention does not contain ethanol.
- the content of ethanol is 3% by mass or less, preferably 0 to 3% by mass, more preferably 0 to 2.5% by mass in the liquid oral cavity composition of the present invention. %, More preferably 0 to 2% by mass, and still more preferably 0 to 1% by mass, or the liquid oral cavity composition containing a foam discharge container of the present invention preferably does not contain ethanol.
- the mass ratio of these ethanol and component (a-1) is preferably 15 or less, more preferably 10 or less, and even more preferably 8 or less, from the viewpoint of effectively suppressing an increase in viscosity at low temperatures.
- the content of the abrasive powder is 0.5% by mass or less.
- abrasive powder include light calcium carbonate, heavy calcium carbonate, zeolite, abrasive silica having an oil absorption of 50 to 150 mL / 100 g, dicalcium phosphate, tricalcium phosphate, insoluble sodium metaphosphate, aluminum hydroxide, Examples thereof include one or more selected from magnesium phosphate, calcium pyrophosphate, magnesium carbonate, and the like.
- the amount of oil absorption indicates the amount of oil that can be supported by silica, and the measurement method is specified by the method based on JIS K5101-13-2 (established in 2004) and specified by the amount of boiled oil absorbed. To do.
- the content of the abrasive powder is 0.5% by mass in the liquid oral cavity composition containing the foam discharge container of the present invention, from the viewpoint of ensuring low-temperature storage stability while ensuring good discharge properties from the container. Or less, preferably 0.4% by mass or less, more preferably 0.3% by mass or less, preferably more than 0% by mass, or the liquid oral cavity composition in a foam discharge container of the present invention is It is preferable that no abrasive powder is contained.
- the content of the abrasive powder is 0.5% by mass or less, preferably 0 to 0.5% by mass, more preferably in the liquid oral cavity composition in the foam discharge container of the present invention. It is preferably 0 to 0.4% by mass, more preferably 0 to 0.3% by mass, or the liquid oral cavity composition containing a foam discharge container of the present invention preferably does not contain an abrasive powder.
- the liquid oral cavity composition containing a foam discharge container of the present invention has a binder content of 0.3% by mass or less.
- binder examples include sodium alginate, carboxymethylcellulose or a salt thereof, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum , Tamarind gum, psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate, and a methoxyethylene maleic anhydride copolymer.
- the degree of etherification is One or two or more kinds selected from 0.7 to 2.0 carboxymethyl cellulose or a salt thereof, hydroxyethyl cellulose, carrageenan, and xanthan gum are preferable, and two or more kinds are more preferably used in combination.
- the content of the binder is 0.3 in the liquid oral cavity composition containing the foam discharge container of the present invention from the viewpoint of securing good dischargeability from the container and enhancing the storage stability at low temperature.
- % Or less preferably 0.28% by mass or less, more preferably 0.25% by mass or less, preferably from the viewpoint of ensuring good foam quality and feeling of use by increasing the foam viscosity. It is 0.05 mass% or more, More preferably, it is 0.1 mass% or more, or the liquid oral cavity composition in a foam discharge container of this invention does not need to contain a binder.
- the liquid oral cavity composition containing a foam discharge container of the present invention has a nonionic surfactant content of 1.2% by mass or less. By limiting the content of the nonionic surfactant in this way, it is possible to effectively suppress an increase in viscosity at low temperatures and improve storage stability.
- nonionic surfactants include polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester such as pentaglyceryl monomyristate, alkyl glucoside, polyglycerin fatty acid ester, polyoxyethylene monoalkyl (Or alkenyl) ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether such as polyoxyethylene nonylphenyl ether, amine oxide surfactant, mono- (or di-) ethanolamide, coconut oil Fatty acid alkanolamides such as fatty acid diethanolamide, glycerin fatty acid esters such as monoglyceryl stearate and decaglyceryl monostearate, decaglyceryl laurate Polyglycerol fatty acid esters, and one or more selected from polyethylene glycols such as polyethylene polypropylene glycol.
- the nonionic surfactants include
- the content of the nonionic surfactant is a viewpoint that effectively suppresses the increase in viscosity at a low temperature
- the liquid oral cavity composition of the present invention contains a specific bactericide such as isopropylmethylphenol as described later.
- a specific anti-inflammatory agent from the viewpoint of enhancing the adsorptivity in the oral cavity, in the liquid oral cavity composition containing the foam discharge container of the present invention, 1.2% by mass or less, Preferably it is 1.1 mass% or less, More preferably, it is 1.0 mass% or less, More preferably, it is 0.7 mass% or less, More preferably, it is 0.5 mass% or less, or this
- the liquid oral cavity composition in the foam discharge container of the invention may not contain a nonionic surfactant.
- the liquid oral cavity composition containing a foam discharge container of the present invention has a solid sugar alcohol content of 5% by mass or less at 20 ° C.
- a sugar alcohol is a polyol other than the component (B), and prevents the pressure at the time of discharge from becoming unnecessarily high.
- the pressure at the time of the first press after storage and the first discharge state after the storage From the viewpoint of improving, for example, effectively prevents clogging in the porous member due to the adhesion of the composition to the porous member of the foam discharge container, even after storage in a dry state or at a high temperature.
- Examples of the solid sugar alcohol at 20 ° C. include sorbitol, xylitol, erythritol, mannitol, and reduced palatinose.
- the content of the solid sugar alcohol at 20 ° C. is 5% by mass in the liquid oral cavity composition containing the foam discharge container of the present invention from the viewpoint of maintaining excellent discharge performance and improving the uniform foam performance. Or less, preferably 3% by mass or less, more preferably 1% by mass or less, still more preferably 0.5% by mass or less, and still more preferably 0.1% by mass or less. It is preferably 0.05% by mass or less, or preferably contains no sugar alcohol solid at 20 ° C.
- the liquid oral cavity composition containing a foam discharge container of the present invention may contain a thickening silica having an oil absorption of 180 to 350 mL / 100 g, that is, a silica having a large oil absorption, which is different from the abrasive silica.
- the content of the thickening silica is preferably 1% by mass or less, more preferably 0, in the liquid oral cavity composition in the foam discharge container of the present invention, from the viewpoint of securing good dischargeability from the container. .5% by mass or less.
- the oil absorption is specified by the same measurement method as that for the abrasive silica.
- the liquid oral cavity composition containing a foam discharge container of the present invention may further contain a cationic bactericidal agent in an amount of 0.005% by mass to 0.1% by mass.
- the liquid oral cavity composition in the foam discharge container of the present invention exhibits high low-temperature storage stability while maintaining an appropriate viscosity even after storage at low temperature while maintaining good foam quality. Effectively embedding a fungicide in a foam to effectively enhance the adsorptive properties of the oral cavity and the oral mucosal surface (including the gum surface) in the oral cavity, causing causative teeth, periodontal disease, bad breath, etc. It becomes possible to improve the bactericidal effect against the bacteria.
- the liquid oral cavity composition in the foam discharge container of the present invention includes these cationic bactericides and also contains triclosan and isopropylmethylphenol which are bactericides other than the cationic bactericides described later. It is possible to effectively enhance the adsorptivity of the bactericidal agent to the tooth surface and the oral mucosal surface in the oral cavity and exert an excellent bactericidal effect. That is, the liquid oral cavity composition in the foam discharge container of the present invention is also useful as an adsorption promoter in the oral cavity of one or more germicides selected from cationic germicide, triclosan, and isopropylmethylphenol. is there. The contents of triclosan and isopropylmethylphenol are as described later.
- Examples of the cationic bactericides include one or more selected from quaternary ammonium compounds and biguanide compounds.
- Specific examples of the bactericidal agent belonging to the quaternary ammonium compound include cetylpyridinium chloride, benzethonium chloride, depotassium chloride, benzalkonium chloride, alkyldimethylammonium chloride, alkyltrimethylammonium chloride, and methylbenzethonium chloride. 1 type, or 2 or more types.
- Specific examples of the bactericide belonging to the biguanide compound include one or more selected from chlorhexidine and salts thereof.
- a quaternary ammonium compound as a cationic bactericidal agent 1 or 2 selected from cetylpyridinium chloride and benzethonium chloride is preferable, and cetylpyridinium chloride is more preferable.
- the content of the cationic bactericide is preferably 0.005% by mass or more, more preferably 0.005% by mass or more in the liquid oral cavity composition of the present invention from the viewpoint of effectively expressing the bactericidal action. It is 007 mass% or more.
- the content of the cationic bactericidal agent is preferably 0.1% by mass or less, more preferably in the liquid oral cavity composition in the foam discharge container of the present invention, from the viewpoint of securing a good usability. It is 0.08 mass% or less.
- the content of the cationic disinfectant is preferably 0.005% by mass or more and 0.1% by mass or less, more preferably 0.007 to 0.1% in the liquid oral cavity composition in the foam discharge container of the present invention. 0.08% by mass.
- the liquid oral cavity composition containing a foam discharge container of the present invention may further contain one or more selected from isopropylmethylphenol, triclosan, and glycyrrhizic acid or a salt thereof.
- isopropylmethylphenol and triclosan are bactericides other than the above cationic bactericides, so-called nonionic bactericides (non-cationic bactericides), and glycyrrhizic acid and its salts are anti-inflammatory agents.
- the liquid oral cavity composition of the present invention with a foam discharge container exhibits high low-temperature storage stability while maintaining an appropriate viscosity even after storage at low temperatures while maintaining good foam quality.
- a bactericidal agent or an anti-inflammatory agent can be effectively embedded in foam to effectively enhance the adsorptivity in the oral cavity.
- dipotassium glycyrrhizinate is preferable.
- one or two selected from triclosan and dipotassium glycyrrhizinate are more preferable.
- the content of one or more selected from isopropylmethylphenol, triclosan, and glycyrrhizic acid or a salt thereof is for the liquid oral cavity containing the foam discharge container of the present invention from the viewpoint of effectively expressing bactericidal action and anti-inflammatory effect.
- a composition Preferably it is 0.005 mass% or more, More preferably, it is 0.007 mass% or more.
- the content of one or more selected from isopropylmethylphenol, triclosan, and glycyrrhizic acid or a salt thereof is used for the liquid oral cavity containing the foam discharge container of the present invention from the viewpoint of securing a good feeling of use and flavor.
- a composition Preferably it is 0.1 mass% or less, More preferably, it is 0.08 mass% or less.
- the content of 1 type (s) or 2 or more types selected from isopropylmethylphenol, triclosan, and glycyrrhizic acid or a salt thereof is preferably 0.005% by mass in the liquid oral cavity composition in the foam discharge container of the present invention.
- the content is 0.1% by mass or less and more preferably 0.007 to 0.08% by mass.
- the content of isopropylmethylphenol is preferably 0.02% by mass or less in the liquid oral cavity composition in the foam discharge container of the present invention, from the viewpoint of enhancing stability after low-temperature storage, and more preferably 0.01% by mass or less.
- the liquid oral cavity composition containing a foam discharge container of the present invention may contain a polyol other than the above sugar alcohol that is solid at 20 ° C. as a polyol other than the component (B).
- the polyol that is solid at 20 ° C. include sugars such as trehalol, maltose, isomalt, and polyethylene glycol having a mass average molecular weight of more than 1000.
- the content of polyols other than the above sugar alcohol, which is solid at 20 ° C. is preferably 1% by mass or less in the liquid oral cavity composition of the present invention from the viewpoint of improving the dischargeability. More preferably 0.5% by mass or less, further preferably 0.1% by mass or less, still more preferably 0.05% by mass or less, or a solid at 20 ° C. other than the sugar alcohol. It is not necessary to contain a polyol.
- the liquid oral cavity composition in the foam discharge container of the present invention can also contain an oily component (X) which is an oily component other than the component (A), nonionic surfactant, isopropylmethylphenol, triclosan, and glycyrrhizic acid.
- oily component of component (X) include one or more selected from a fragrance, a preservative, a fungicide other than isopropylmethylphenol, triclosan, and a cationic fungicide, and a medicinal agent other than glycyrrhizic acid. Is mentioned.
- Preservatives include, for example, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, benzoic acid, sodium benzoate, methyl salicylate, potassium sorbate And sodium dehydroacetate.
- the fragrance may be any fragrance exhibiting oil solubility, for example, peppermint oil, spearmint oil, cinnamon oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, sage clary oil.
- Natural flavoring ingredients such as caraway oil, marjoram oil, bay oil, lemongrass oil, lemon balm oil, pimento berry oil, palmarosa oil, olibanum oil, pine needle oil, pettigren oil, neroli oil, rose oil, jasmine oil, and Perfume ingredients processed from these natural perfume ingredients; , Pretol, carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-1-menthoxypropane-1,2-diol, thymol, citronellyl acetate, linalool, linalyl acetate, geraniol, geranyl acetate, citronellol
- Examples of medicinal agents include anti-inflammatory agents such as azulenes, tocopherols, hinokitiol, glycyrrhetinic acid and dihydrocholesterol; plant extract oils such as chamomile oil and latania oil.
- Examples of the azulene include azulene, guaiazulene, and guaiazulene sulfonic acid.
- Examples of the tocopherol include dl- ⁇ -tocopherol acetate and tocopherol nicotinate.
- Examples of the glycyrrhetinic acid include ⁇ -glycyrrhetinic acid and ⁇ -glycyrrhetin. Examples include acids.
- the liquid oral cavity composition containing a foam discharge container of the present invention contains the oil component of the component (X), the mass ratio of the component (X) to the total content of the component (A) and the nonionic surfactant ((X) / ((A) + nonionic surfactant)) is a liquid oral composition containing a foam discharge container according to the present invention in terms of ensuring good usability in the oral cavity, and the isopropylmethylphenol and triclosan.
- one or more selected from glycyrrhizic acid or a salt thereof it is preferably 0.05 or more, more preferably 0.00 from the viewpoint of enhancing the adsorptivity in the oral cavity. It is 08 or more, more preferably 0.1 or more.
- the mass ratio of component (X) to the total content of component (A) and nonionic surfactant ((X) / ((A) + nonionic surfactant)) ensures storage stability at low temperatures. In view of the above, it is preferably 5 or less, more preferably 4.5 or less, and even more preferably 4 or less.
- the mass ratio of the component (X) to the total content of the component (A) and the nonionic surfactant ((X) / ((A) + nonionic surfactant)) is preferably 0.05 to 5. More preferably 0.08 to 4.5, and still more preferably 0.1 to 4.
- the content of the oil component of component (X) is in the liquid oral cavity composition containing the foam discharge container of the present invention from the viewpoint of ensuring storage stability at a low temperature while imparting a good flavor and feeling of use.
- it is 0.1 mass% or more, More preferably, it is 0.15 mass% or more, More preferably, it is 0.2 mass% or more, Preferably it is 2 mass% or less, More preferably, it is 1. It is 8 mass% or less, More preferably, it is 1.5 mass% or less.
- the liquid oral cavity composition containing a foam discharge container of the present invention can appropriately contain, for example, a pH adjuster, a pigment, a dye, and the like in addition to the above components within a range not inhibiting the effects of the present invention.
- the liquid oral cavity composition containing a foam discharge container of the present invention is filled in a foam discharge container having a discharge port.
- the liquid oral composition as a content is directly discharged into the oral cavity from the discharge opening provided in the foam discharge container.
- the liquid composition for oral cavity is applied to the oral cavity in the form of foam. As a result, it is possible to spread the liquid oral composition to every corner of the oral cavity while realizing an excellent feeling of use by providing a good foam quality, which is also useful as a foamy liquid oral composition. It is a highly composition.
- composition for liquid oral cavity containing a foam discharge container of the present invention contains one or two or more selected from the above-mentioned isopropylmethylphenol, triclosan, and glycyrrhizic acid or a salt thereof, or the above cationic fungicide.
- Triclosan, and isopropylmethylphenol even when containing one or more fungicides, as a foamy liquid oral composition, the adsorptivity of these components in the oral cavity is enhanced and the desired effect Such performance can be maintained well even after low-temperature storage.
- the foam discharge container filled with the liquid oral composition may be any one provided with a discharge port, and may be a non-aerosol type container or an aerosol type container.
- the non-aerosol type container is also referred to as a non-aerosol container, and is a normal pressure container that does not require a propellant such as compressed gas.
- a container examples include a squeeze type container and a pump type container.
- These containers have a viewpoint of forming a foamy composition satisfactorily when the contents pass through the discharge port, and the formed foam has good retention and homogeneity, and enhances the feeling of use, etc. From this point of view, it is preferable that any of these is a container in which a porous member provided with a mesh or a plurality of small holes is interposed in the flow path of the contents from the container main body to the discharge port.
- the squeeze-type container is also called a squeeze container, and by squeezing the trunk located in the deformable container body, the air that is pumped from the head space while passing through the porous member as needed The contents are mixed to form bubbles, and the bubbles are discharged from the discharge port.
- the containers described in JP-A-7-215352, JP-A-58-174272, and JP-A-62-42787 can be used.
- the pump type container is also called a pump container.
- a pump container By pushing a pump head provided in a foam discharger having a discharge port, air and contents flowing in from outside while passing through a porous member as necessary. Are mixed to form bubbles, and the bubbles are discharged from the discharge port.
- an air cylinder for allowing air to flow in from the outside and a liquid cylinder serving as a flow path for the contents are provided, and a mixing chamber for mixing the air and the contents that are pumped by the pump head being pushed in.
- containers described in JP-A-7-315463, JP-A-8-230961 and JP-A-3-7963 can be used.
- An aerosol-type container also called an aerosol container, is a container filled with compressed gas as a propellant. When the contents are discharged from the discharge port, bubbles are formed while taking in the gas through the valve mechanism.
- the compressed gas to be used is preferably a gas containing 90% by mass or more of carbon dioxide gas.
- a squeeze container is preferable from the viewpoint of usability, that is, from the viewpoint of easily discharging the contents directly from the discharge port into the oral cavity, and from the viewpoint of excellent convenience and portability. More preferably, the container is provided with a mesh of # 90 to # 305 in the flow path of the contents from to the discharge port.
- the viscosity of the liquid oral cavity composition in the foam discharge container of the present invention is preferably 85 mPa ⁇ s or less, more preferably 65 mPa ⁇ s, even at 25 ° C. and ⁇ 5 ° C., from the viewpoint of improving discharge properties at low temperatures. s or less, more preferably 60 mPa ⁇ s or less, even more preferably 55 mPa ⁇ s or less, even more preferably 50 mPa ⁇ s or less, preferably 5 mPa ⁇ s or more, more preferably 10 mPa ⁇ s or less. -It is more than s.
- the viscosity of the liquid oral composition of the present invention was measured at 25 ° C.
- the following liquid oral cavity composition containing a foam discharge container and a method for using the same are disclosed.
- Component (a-1) is preferably N-lauroyl sarcosine salt, N-lauroylmethyl taurine salt, N-lauroyl taurine salt, N-myristoyl glutamate, N-lauroyl glutamate, lauryl sulfate, lauryl phosphorus
- the liquid oral cavity composition according to the above [1] which is one or two or more selected, preferably alkali metal salts thereof, more preferably sodium salts and potassium salts, and still more preferably sodium salts.
- the content of component (a-1) is 1.2% by mass or less, preferably 1% by mass or less, more preferably 0.8% by mass or less, preferably 0.1% by mass or less.
- the content of the anionic surfactant which is a fatty acid or a salt thereof is preferably 0.2% by mass or less, more preferably 0.1% by mass or less, and further preferably 0.01% by mass or less.
- Component (a-2) is preferably one or more selected from coconut oil fatty acid amide alkylbetaine and alkylsulfobetaine, more preferably coconut oil fatty acid amide alkylbetaine, and more preferably The liquid oral cavity composition in a foam discharge container according to any one of the above [1] to [4], wherein is a coconut oil fatty acid amidopropyl betaine.
- the content of one or more surfactants selected from the component (a-1) and the component (a-2) in the component (A) is preferably 0.4% by mass in total.
- the liquid oral cavity composition in any one of the above [1] to [5], which is preferably 1.7% by mass or less, and more preferably 1.3% by mass or less.
- the mass ratio ((a-2) / (a-1)) of the component (a-2) to the component (a-1) is preferably 0.5 or more, more preferably 0.55 or more.
- liquid oral cavity composition in any one of the above [1] to [6], which is more preferably 1.8 or less, and still more preferably 1.3 or less.
- Component (B) is preferably one or two or more polyols selected from glycerin, propylene glycol, and butylene glycol, and the liquid oral cavity containing one of the above [1] to [7] Composition. [9] The content of component (B) is, in total, preferably 12% by mass or more, more preferably 15% by mass or more, preferably 37% by mass or less, more preferably 35% by mass or less.
- the content of polyethylene glycol having an average molecular weight of 1000 or less used as the component (B) is preferably 7% by mass or less, more preferably 5% by mass or less, More preferably, it is 3% by mass or less, more preferably 2% by mass or less, or preferably it contains no polyethylene glycol having an average molecular weight of 1000 or less.
- Liquid oral composition The content of polyols other than solid sugar alcohol at 20 ° C. is preferably 1% by mass or less, more preferably 0.5% by mass or less, and further preferably 0.1% by mass or less.
- the composition is a liquid oral cavity composition in any one of the above [1] to [9], which is 0.05% by mass or less or does not contain a solid polyol at 20 ° C.
- the mass ratio ((B) / (A)) between the component (B) and the component (A) is preferably 6 or more, more preferably 8 or more, still more preferably 10 or more, and more More preferably, it is 12 or more, preferably 130 or less, more preferably 90 or less, still more preferably 70 or less, still more preferably 55 or less, and still more preferably 52 or less.
- the liquid oral cavity composition in any one of foam discharge containers.
- the content of component (C) is preferably 55% by mass or more, more preferably 60% by mass or more, still more preferably 65% by mass or more, and preferably 86% by mass or less.
- the mass ratio ((A) / (C)) of the component (A) to the component (C) is preferably 0.5 ⁇ 10 ⁇ 2 or more, more preferably 0.6 ⁇ 10 ⁇ 2 or more. More preferably 0.75 ⁇ 10 ⁇ 2 or more, still more preferably 0.8 ⁇ 10 ⁇ 2 or more, preferably 5 ⁇ 10 ⁇ 2 or less, more preferably 4.4 ⁇ . 10 ⁇ 2 or less, more preferably 2.5 ⁇ 10 ⁇ 2 or less, and even more preferably 2 ⁇ 10 ⁇ 2 or less.
- the content of ethanol is preferably 2.5% by mass or less, more preferably 2% by mass or less, still more preferably 1% by mass or less, preferably more than 0% by mass, or ethanol
- the content of the abrasive powder is preferably 0.4% by mass or less, more preferably 0.3% by mass or less, preferably more than 0% by mass, or contains no abrasive powder.
- the liquid oral cavity composition in any one of foam discharge containers.
- the content of the binder is preferably 0.28% by mass or less, more preferably 0.25% by mass or less, preferably 0.05% by mass or more, and more preferably 0.8% by mass.
- the content of the nonionic surfactant is preferably 1.1% by mass or less, more preferably 1.0% by mass or less, still more preferably 0.7% by mass or less, and still more preferably.
- the content of the solid sugar alcohol at 20 ° C. is preferably 3% by mass or less, more preferably 1% by mass or less, still more preferably 0.5% by mass or less, and still more preferably The liquid in a foam discharge container according to any one of the above [1] to [17], which is 0.1% by mass or less, more preferably 0.05% by mass or less, or does not contain a solid sugar alcohol at 20 ° C. Oral composition.
- sorbitol is one or more selected from sorbitol, xylitol, erythritol, mannitol, and reduced palatinose, and is contained in any one of the foam discharge containers of [1] to [18] above Liquid oral composition.
- a cationic fungicide is further contained, and the cationic fungicide is preferably one or more selected from quaternary ammonium compounds and biguanide compounds, and any one of the above [1] to [19] A composition for liquid oral cavity containing 1 foam discharge container.
- the content of the cationic fungicide is preferably 0.005% by mass or more, more preferably 0.007% by mass or more, preferably 0.1% by mass or less, more preferably 0.
- isopropylmethylphenol, triclosan, and one or more selected from glycyrrhizic acid or a salt thereof are contained, and the content thereof is preferably 0.005% by mass or more, more preferably 0. 0.007% by mass or more, preferably 0.1% by mass or less, more preferably 0.08% by mass or less, and the liquid oral cavity composition according to any one of the above [1] to [21] object.
- the composition for liquid oral cavity of [22] or [23] above, wherein the content of isopropylmethylphenol is preferably 0.02% by mass or less, more preferably 0.01% by mass or less. object.
- Oil component (X) which is an oil component other than component (A), nonionic surfactant, isopropylmethylphenol, triclosan, and glycyrrhizic acid, and the content of component (A) and nonionic surfactant
- the mass ratio of the component (X) to the total of ((X) / ((A) + nonionic surfactant)) is preferably 0.05 or more, more preferably 0.08 or more, Preferably it is 0.1 or more, preferably 5 or less, more preferably 4.5 or less, and further preferably 4 or less, the liquid in a foam discharge container according to any one of the above [1] to [24] Oral composition.
- the content of the oil component (X) is preferably 0.1% by mass or more, more preferably 0.15% by mass or more, further preferably 0.2% by mass or more, preferably
- the foam discharge container is preferably a non-aerosol container or an aerosol container having a discharge port, preferably a non-aerosol container selected from a squeeze container and a pump container.
- Liquid oral cavity composition in a foam discharge container is preferably a non-aerosol container or an aerosol container having a discharge port, preferably a non-aerosol container selected from a squeeze container and a pump container.
- the liquid oral cavity composition containing the foam ejection container is directly ejected into the oral cavity from the ejection opening provided in the foam ejection container, and the liquid oral composition containing the foam ejection container via the ejection opening is foamed into the oral cavity
- Adsorption amount of medicinal components in foam or liquid was evaluated according to the following method. In addition, those obtained by discharging each liquid oral composition obtained from the discharge port of the pump former container as a foam, and those obtained by using each liquid oral composition directly as a liquid are used. did.
- a cylindrical container (inner diameter 2.5 cm) having no bottom surface and an open top surface was disposed on each silicone sheet, and the lower end of the side surface of the container was brought into close contact with the silicone sheet.
- 1.5 g each of the foam or liquid was put into another container, and the foam or liquid was applied to the surface of the silicone sheet surrounded and exposed on the side of the container. .
- a pipette tip was inserted from the upper surface of the container, and pipetting was performed for 30 seconds.
- the obtained silicone sheet was washed 3 times with 2 mL of purified water, 2 mL of the extract (the mobile phase shown below corresponding to each medicinal component) was applied for 30 seconds and recovered, and then by high performance liquid chromatography (HPLC), Each medicinal component was quantified (ng / cm 2 ) according to the following measurement conditions.
- Comparative Example 1 in which the ethanol content exceeds 3% by mass
- Comparative Example 2 in which the binder content exceeds 0.3% by mass
- the content of the nonionic surfactant Comparative Example 3 in which the content exceeds 1.2 mass%
- Comparative Example 4 in which the content of component (B) is less than 10 mass%, the content of component (a-2) while containing component (a-1) Is less than 0.25% by mass
- Comparative Example 6 in which the content of the component (a-1) exceeds 1.2% by mass, and the content of the solid sugar alcohol at 20 ° C. is 5% by mass.
- the Examples 1 to 34 all have high foam viscosity when discharged from the container and good foam quality, storage stability at low temperature and dischargeability from the container at low temperature, or It turns out that it is excellent in the discharge property after high temperature storage. Further, as shown in the results of Tables 5 to 6, in any of the examples, various medicinal ingredients were maintained while maintaining good foam quality, excellent storage stability at low temperature and dischargeability from the container. It can be seen that it exhibits high adsorptivity in the oral cavity.
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Abstract
Description
(特許文献2)特開平10-167943号公報
(特許文献3)特開平8-333226号公報
(特許文献4)特開平9-295923号公報
(A)N-アシルアミノ酸塩、アルキル硫酸エステル塩、アルキルリン酸塩、及びα-オレフィンスルホン酸塩から選ばれるアニオン界面活性剤(a-1)、並びに両性界面活性剤(a-2)から選ばれる1種又は2種以上の界面活性剤 合計で0.3質量%以上2.5質量%以下
(B)グリセリン、プロピレングリコール、ブチレングリコール、及び平均分子量1000以下のポリエチレングリコールから選ばれる1種又は2種以上のポリオール 合計で10質量%以上40質量%以下、並びに
(C)水 50質量%以上89質量%以下
を含有し、成分(a-1)の含有量が1.2質量%以下であるか、或いは成分(a-1)を含有せず、かつ成分(a-2)の含有量が0.25質量%以上1.5質量%以下であり、
さらに、エタノールの含有量が3質量%以下であり、研磨性紛体の含有量が0.5質量%以下であり、粘結剤の含有量が0.3質量%以下であり、ノニオン界面活性剤の含有量が1.2質量%以下であり、かつ20℃において固体の糖アルコールの含有量が5質量%以下である、泡吐出容器入り液体口腔用組成物に関するものである。
また、本発明は、泡吐出容器が備える吐出口から、泡吐出容器入り液体口腔用組成物を口腔内へ直接吐出して、吐出口を経由した泡吐出容器入り液体口腔用組成物を泡状で口腔内へ適用する、上記泡吐出容器入り液体口腔用組成物の使用方法に関するものである。
本発明の泡吐出容器入り液体口腔用組成物は、成分(A)として、N-アシルアミノ酸塩、アルキル硫酸エステル塩、アルキルリン酸塩、及びα-オレフィンスルホン酸塩から選ばれるアニオン界面活性剤(a-1)、並びに両性界面活性剤(a-2)から選ばれる1種又は2種以上の界面活性剤を合計で0.3質量%以上2.5質量%以下含有し、かつ成分(a-1)の含有量が1.2質量%以下であるか、或いは成分(a-1)を含有せず、かつ成分(a-2)の含有量が0.25質量%以上1.5質量%以下である。すなわち、本発明の泡吐出容器入り液体口腔用組成物において、成分(A)の界面活性剤は、N-アシルアミノ酸塩、アルキル硫酸エステル塩、アルキルリン酸塩、及びα-オレフィンスルホン酸塩から選ばれるアニオン界面活性剤(a-1)と両性界面活性剤(a-2)から選ばれる1種又は2種以上であって、これらの合計含有量が0.3質量%以上2.5質量%以下であり、成分(a-2)の両性界面活性剤を0.25質量%以上1.5質量%以下で含有するなかで、成分(a-1)のアニオン界面活性剤を含有しなくともよく、また成分(a-1)のアニオン界面活性剤を1.2質量%以下で含有する場合には、成分(a-1)とともに成分(a-2)の両性界面活性剤を0.25質量%以上1.5質量%以下で含有すればよい。このように、成分(A)の界面活性剤を限られた量で含有するなか、良好な泡質をもたらし得るものの低温環境下では析出物を生じやすい成分(a-1)のアニオン界面活性剤の含有を制限しつつ、さらに成分(a-2)の両性界面活性剤を特定量で含有することにより、成分(a-1)による析出物の発生を有効に抑制しながら、低温保存後においても適度な粘度を保持し、容器からの吐出性や使用感を高めつつ、優れた低温保存安定性を発揮することができる。
なかでも、起泡性や洗浄性の観点、及び安定性の観点から、成分(a-1)のアニオン界面活性剤として、N-ラウロイルサルコシン塩、N-ラウロイルメチルタウリン塩、N-ラウロイルタウリン塩、N-ミリストイル-L-グルタミン酸塩、N-ラウロイルグルタミン酸塩、及びラウリル硫酸塩、ラウリルリン酸塩、α-オレフィン(C14~16)スルホン酸塩から選ばれる1種又は2種以上が好ましく、泡切れの良さ、或いは口腔内に適用する際の殺菌性又は湿潤性の観点から、N-ラウロイルメチルタウリン塩、N-ミリストイルグルタミン酸塩、及びラウリル硫酸塩から選ばれる1種又は2種以上がより好ましく、これらの塩としては、アルカリ金属塩が好ましく、ナトリウム塩、カリウム塩がより好ましく、ナトリウム塩がさらに好ましい。また、発泡性の観点から、成分(a-1)のアニオン界面活性剤として、少なくともラウリル硫酸ナトリウムを含むものが好ましい。
成分(B)として用いるポリエチレングリコールの質量平均分子量は、低温保存安定性と泡吐出容器の多孔質部材の目詰まりを防止する観点から、1000以下であって、好ましくは850以下であり、良好な泡質の観点から、好ましくは200以上であり、より好ましくは400以上である。
なお、吸油量とは、シリカが担持できる油量を示したものであり、測定方法はJIS K5101-13-2(2004年制定)に基づく方法により、吸収される煮あまに油の量により特定する。
[1]次の成分(A)、(B)並びに(C):
次の成分(A)、(B)並びに(C):
(A)N-アシルアミノ酸塩、アルキル硫酸エステル塩、アルキルリン酸塩、及びα-オレフィンスルホン酸塩から選ばれるアニオン界面活性剤(a-1)、並びに両性界面活性剤(a-2)から選ばれる1種又は2種以上の界面活性剤 合計で0.3質量%以上2.5質量%以下
(B)グリセリン、プロピレングリコール、ブチレングリコール、及び平均分子量1000以下のポリエチレングリコールから選ばれる1種又は2種以上のポリオール 合計で10質量%以上40質量%以下、並びに
(C)水 50質量%以上89質量%以下
を含有し、成分(a-1)の含有量が1.2質量%以下であるか、或いは成分(a-1)を含有せず、かつ成分(a-2)の含有量が0.25質量%以上1.5質量%以下であり、
さらに、エタノールの含有量が3質量%以下であり、研磨性紛体の含有量が0.5質量%以下であり、粘結剤の含有量が0.3質量%以下であり、ノニオン界面活性剤の含有量が1.2質量%以下であり、かつ20℃において固体の糖アルコールの含有量が5質量%以下である、泡吐出容器入り液体口腔用組成物。
[3]成分(a-1)の含有量は、1.2質量%以下であって、好ましくは1質量%以下であり、より好ましくは0.8質量%以下であり、好ましくは0.1質量%以上であり、より好ましくは0.2質量%以上であり、或いは成分(a-1)を含有しない上記[1]又は[2]の泡吐出容器入り液体口腔用組成物。
[4]脂肪酸又はその塩であるアニオン界面活性剤の含有量は、好ましくは0.2質量%以下であり、より好ましくは0.1質量%以下であり、さらに好ましくは0.01質量%以下であり、好ましくは0質量%を超え、或いはさらに好ましくは脂肪酸又はその塩であるアニオン界面活性剤を含有しない上記[1]~[3]いずれか1の泡吐出容器入り液体口腔用組成物。
[6]成分(A)の、成分(a-1)及び成分(a-2)から選ばれる1種又は2種以上の界面活性剤の含有量は、合計で、好ましくは0.4質量%以上であり、より好ましくは0.5質量%以上であり、さらに好ましくは0.6質量%以上であり、好ましくは2.2質量%以下であり、より好ましくは2質量%以下であり、さらに好ましくは1.7質量%以下であり、よりさらに好ましくは1.3質量%以下である上記[1]~[5]いずれか1の泡吐出容器入り液体口腔用組成物。
[7]成分(a-2)と成分(a-1)の質量比((a-2)/(a-1))は、好ましくは0.5以上であり、より好ましくは0.55以上であり、さらに好ましくは0.6以上であり、よりさらに好ましくは0.65以上であり、好ましくは3以下であり、より好ましくは2.5以下であり、さらに好ましくは2以下であり、よりさらに好ましくは1.8以下であり、よりさらに好ましくは1.3以下である上記[1]~[6]いずれか1の泡吐出容器入り液体口腔用組成物。
[9]成分(B)の含有量は、合計で、好ましくは12質量%以上であり、より好ましくは15質量%以上であり、好ましくは37質量%以下であり、より好ましくは35質量%以下であり、さらに好ましくは32質量%以下であり、成分(B)として用いる平均分子量1000以下のポリエチレングリコールの含有量は、好ましくは7質量%以下であり、より好ましくは5質量%以下であり、さらに好ましくは3質量%以下であり、よりさらに好ましくは2質量%以下であり、或いは好ましくは平均分子量1000以下のポリエチレングリコールを含有しない上記[1]~[8]いずれか1の泡吐出容器入り液体口腔用組成物。
[10]20℃において固体の糖アルコール以外のポリオールの含有量は、好ましくは1質量%以下であり、より好ましくは0.5質量%以下であり、さらに好ましくは0.1質量%以下であり、よりさらに好ましくは0.05質量%以下であり、或いは20℃において固体のポリオールを含有しない上記[1]~[9]いずれか1の泡吐出容器入り液体口腔用組成物。
[11]成分(B)と成分(A)の質量比((B)/(A))は、好ましくは6以上であり、より好ましくは8以上であり、さらに好ましくは10以上であり、よりさらに好ましくは12以上であり、好ましくは130以下であり、より好ましくは90以下であり、さらに好ましくは70以下であり、よりさらに好ましくは55以下であり、よりさらに好ましくは52以下である上記[1]~[10]いずれか1の泡吐出容器入り液体口腔用組成物。
[13]成分(A)と成分(C)の質量比((A)/(C))は、好ましくは0.5×10-2以上であり、より好ましくは0.6×10-2以上であり、さらに好ましくは0.75×10-2以上であり、よりさらに好ましくは0.8×10-2以上であり、好ましくは5×10-2以下であり、より好ましくは4.4×10-2以下であり、さらに好ましくは2.5×10-2以下であり、よりさらに好ましくは2×10-2以下である上記[1]~[12]いずれか1の泡吐出容器入り液体口腔用組成物。
[15]研磨性紛体の含有量は、好ましくは0.4質量%以下であり、より好ましくは0.3質量%以下であり、好ましくは0質量%を超え、或いは研磨性紛体を含有しない上記[1]~[14]いずれか1の泡吐出容器入り液体口腔用組成物。
[16]粘結剤の含有量は、好ましくは0.28質量%以下であり、より好ましくは0.25質量%以下であり、好ましくは0.05質量%以上であり、より好ましくは0.1質量%以上であり、或いは粘結剤を含有しない上記[1]~[15]いずれか1の泡吐出容器入り液体口腔用組成物。
[17]ノニオン界面活性剤の含有量は、好ましくは1.1質量%以下であり、より好ましくは1.0質量%以下であり、さらに好ましくは0.7質量%以下であり、よりさらに好ましくは0.5質量%以下であり、或いはノニオン界面活性剤を含有しない上記[1]~[16]いずれか1の泡吐出容器入り液体口腔用組成物。
[18]20℃において固体の糖アルコールの含有量は、好ましくは3質量%以下であり、より好ましくは1質量%以下であり、さらに好ましくは0.5質量%以下であり、よりさらに好ましくは0.1質量%以下であり、よりさらに好ましくは0.05質量%以下であり、或いは20℃において固体の糖アルコールを含有しない上記[1]~[17]いずれか1の泡吐出容器入り液体口腔用組成物。
[19]20℃において固体の糖アルコールは、ソルビトール、キシリトール、エリスリトール、マンニトール、及び還元パラチノースから選ばれる1種又は2種以上である上記[1]~[18]いずれか1の泡吐出容器入り液体口腔用組成物。
[21]カチオン性殺菌剤の含有量は、好ましくは0.005質量%以上であり、より好ましくは0.007質量%以上であり、好ましくは0.1質量%以下であり、より好ましくは0.08質量%以下である上記[20]の泡吐出容器入り液体口腔用組成物。
[22]さらにイソプロピルメチルフェノール、トリクロサン、並びにグリチルリチン酸又はその塩から選ばれる1種又は2種以上を含有し、これらの含有量が、好ましくは0.005質量%以上であり、より好ましくは0.007質量%以上であり、好ましくは0.1質量%以下であり、より好ましくは0.08質量%以下である上記[1]~[21]いずれか1の泡吐出容器入り液体口腔用組成物。
[23]さらにカチオン性殺菌剤、トリクロサン、及びイソプロピルメチルフェノールから選ばれる1種又は2種以上の殺菌剤を含有する上記[1]~[19]いずれか1の泡吐出容器入り液体口腔用組成物。
[24]イソプロピルメチルフェノールの含有量は、好ましくは0.02質量%以下であり、より好ましくは0.01質量%以下である上記[22]又は[23]の泡吐出容器入り液体口腔用組成物。
[26]油性成分(X)は、香料、保存剤、及び薬効剤から選ばれる1種又は2種以上である上記[25]の泡吐出容器入り液体口腔用組成物。
[27]油性成分(X)の含有量は、好ましくは0.1質量%以上であり、より好ましくは0.15質量%以上であり、さらに好ましくは0.2質量%以上であり、好ましくは2質量%以下であり、より好ましくは1.8質量%以下であり、さらに好ましくは1.5質量%以下である上記[25]又は[26]の泡吐出容器入り液体口腔用組成物。
[29]泡状で容器から口腔内へ直接適用するための、上記[1]~[28]いずれか1の泡吐出容器入り液体口腔用組成物の使用。
[30]イソプロピルメチルフェノール、トリクロサン、並びにグリチルリチン酸又はその塩から選ばれる1種又は2種以上の、或いはカチオン性殺菌剤、トリクロサン、及びイソプロピルメチルフェノールから選ばれる1種又は2種以上の殺菌剤の、口腔内での吸着性を高めるための、上記[20]~[28]いずれか1の泡吐出容器入り液体口腔用組成物の使用。
[31]泡吐出容器が備える吐出口から、泡吐出容器入り液体口腔用組成物を口腔内へ直接吐出して、吐出口を経由した泡吐出容器入り液体口腔用組成物を泡状で口腔内へ適用する、上記[1]~[28]いずれか1の泡吐出容器入り液体口腔用組成物の使用方法。
(A)N-アシルアミノ酸塩、アルキル硫酸エステル塩、アルキルリン酸塩、及びα-オレフィンスルホン酸塩から選ばれるアニオン界面活性剤(a-1)、並びに両性界面活性剤(a-2)から選ばれる1種又は2種以上の界面活性剤 合計で0.3質量%以上2.5質量%以下
(B)グリセリン、プロピレングリコール、ブチレングリコール、及び平均分子量1000以下のポリエチレングリコールから選ばれる1種又は2種以上のポリオール 合計で10質量%以上40質量%以下、並びに
(C)水 50質量%以上89質量%以下
を含有し、成分(a-1)の含有量が1.2質量%以下であるか、或いは成分(a-1)を含有せず、かつ成分(a-2)の含有量が0.25質量%以上1.5質量%以下であり、
さらに、エタノールの含有量が3質量%以下であり、研磨性紛体の含有量が0.5質量%以下であり、粘結剤の含有量が0.3質量%以下であり、ノニオン界面活性剤の含有量が1.2質量%以下であり、かつ20℃において固体の糖アルコールの含有量が5質量%以下である、泡状液体口腔用組成物。
[33]カチオン性殺菌剤、トリクロサン、及びイソプロピルメチルフェノールから選ばれる1種又は2種以上の殺菌剤の、口腔内における吸着促進剤である上記[32]の泡状液体口腔用組成物。
表1~6に示す処方にしたがって、液体口腔用組成物を調製し、以下の方法にしたがって、各測定及び評価を行った。
結果を表1~6に示す。
得られた各液体口腔用組成物をガラス瓶に充填し、-5℃で3日間保存した後、BL粘度計(東機産業(株)社製、M1ローター、回転数:30rpm/1分間)を用い、-5℃に保持したままでの液粘度(mPa・s)を測定した。
得られた各液体口腔用組成物100gをポンプフォーマー容器(大和製罐(株)、F5ポンプフォーマー、メッシュ:2枚、メッシュサイズ:#255/#255)に充填し、吐出口から内容物を吐出させ、BH粘度計(東機産業(株)社製、H2ローター、回転数:5rpm/1分間)を用い、室温(25℃)にて泡粘度(mPa・s)を測定した。
得られた各液体口腔用組成物をガラス瓶に充填し、-5℃で3日間保存した後、ガラス瓶の外側から内容物の液体口腔用組成物を目視により観察し、以下の基準にしたがって評価した。
A:完全に透明で均一であった
a:概ね透明で均一であった
B:多少白濁していたものの、均一であった
C:白濁していたものの、析出物までは確認されなかった
D:析出物が確認された
得られた各液体口腔用組成物100gを上記ポンプフォーマー容器に充填し、吐出口から内容物を吐出させた際の泡質に関し、以下の基準にしたがって目視で評価した。
A:泡立ちがよく、泡のキメが細かく均一である
B:泡立ちはよいが、泡のキメが不均一である
C:ポンプを押しにくいため内容物を十分に吐出できない
D:ポンプの押圧性はよいが泡立ちが悪くキメが荒い
《高温保存後の吐出口の状態》
得られた各液体口腔用組成物100gを上記ポンプフォーマー容器に充填し、吐出口から内容物を吐出させた後に、40℃で14日間保存した後、ポンプフィーマの多孔質部材(メッシュ)を取り出し、目視で観察を行い以下の基準に従って評価した。
《高温保存後の吐出口の状態》
A:メッシュに付着物がみられない
B:メッシュに付着物がみられる
C:メッシュに固形の付着物がみられる
薬用成分(塩化セチルピリジニウム、塩化ベンゼトニウム、トリクロサン、グリチルリチン酸ジカリウム)の口腔内での吸着性を以下の方法にしたがって評価した。なお、得られた各液体口腔用組成物を上記ポンプフォーマー容器の吐出口から吐出させたものを泡として採用し、得られた各液体口腔用組成物をそのまま直接用いたものを液として採用した。
得られたシリコーンシートを精製水2mLで3回洗浄し、抽出液2mL(各薬用成分に対応した下記に示す移動相)を30秒間適用して回収した後、高速液体クロマトグラフィー(HPLC)により、下記測定条件にしたがって各薬用成分の定量(ng/cm2)を行った。
装置:日立高速液体クロマトグラム La chromElite
・塩化セチルピリジニウム及び塩化ベンゼトニウムの定量
検出器:紫外吸光光度計(測定波長:CPC=260nm、BTC=215nm)
カラム:CAPCELL PAK SCX UG80(4.6×100mm、5μm)(資生堂(株))
カラム温度:40℃
移動相:メタノール/水の混液(3:1)+0.05mol/L 過塩素酸ナトリウム-水和物
流量:1.2mL/分
検出器:紫外吸光光度計(測定波長:280nm)
カラム:L-column ODS(4.6×100mm、5μm)(化学物質評価研究機構)
カラム温度:40℃
移動相:メタノール/水の混液(4:1)+0.1w/v% リン酸
流量:1.0mL/分
検出器:紫外吸光光度計(測定波長:254nm)
カラム:L-column ODS(4.6×100mm、5μm)(化学物質評価研究機構)
カラム温度:40℃
移動相:メタノール/水の混液(65:35)+0.1w/v% リン酸
流量:1.0mL/分
また、表5~6の結果に示すように、いずれの実施例においても、良好な泡質や低温での優れた保存安定性と容器からの吐出性とを保持しつつ、種々の薬用成分について口腔内での高い吸着性を発揮することがわかる。
Claims (13)
- 次の成分(A)、(B)並びに(C):
(A)N-アシルアミノ酸塩、アルキル硫酸エステル塩、アルキルリン酸塩、及びα-オレフィンスルホン酸塩から選ばれるアニオン界面活性剤(a-1)、並びに両性界面活性剤(a-2)から選ばれる1種又は2種以上の界面活性剤 合計で0.3質量%以上2.5質量%以下
(B)グリセリン、プロピレングリコール、ブチレングリコール、及び平均分子量1000以下のポリエチレングリコールから選ばれる1種又は2種以上のポリオール 合計で10質量%以上40質量%以下、並びに
(C)水 50質量%以上89質量%以下
を含有し、成分(a-1)の含有量が1.2質量%以下であるか、或いは成分(a-1)を含有せず、かつ成分(a-2)の含有量が0.25質量%以上1.5質量%以下であり、
さらに、エタノールの含有量が3質量%以下であり、研磨性紛体の含有量が0.5質量%以下であり、粘結剤の含有量が0.3質量%以下であり、ノニオン界面活性剤の含有量が1.2質量%以下であり、かつ20℃において固体の糖アルコールの含有量が5質量%以下である、泡吐出容器入り液体口腔用組成物。 - 成分(a-1)の含有量が、0.1質量%以上1.2質量%以下である請求項1に記載の泡吐出容器入り液体口腔用組成物。
- さらに、カチオン性殺菌剤を0.005質量%以上0.1質量%以下含有する請求項1又は2に記載の泡吐出容器入り液体口腔用組成物。
- さらに、イソプロピルメチルフェノール、トリクロサン、並びにグリチルリチン酸又はその塩から選ばれる1種又は2種以上を含有する請求項1~3のいずれか1項に記載の泡吐出容器入り液体口腔用組成物。
- 成分(A)、ノニオン界面活性剤、イソプロピルメチルフェノール、トリクロサン、及びグリチルリチン酸以外の油性成分である油性成分(X)を含有し、かつ
成分(A)及びノニオン界面活性剤の含有量の合計に対する成分(X)の質量比((X)/((A)+ノニオン界面活性剤))が、0.05以上5以下である請求項1~4のいずれか1項に記載の泡吐出容器入り液体口腔用組成物。 - 成分(A)と成分(C)の質量比((A)/(C))が、0.5×10-2以上5×10-2以下である請求項1~5のいずれか1項に記載の泡吐出容器入り液体口腔用組成物。
- 成分(a-2)と成分(a-1)の質量比((a-2)/(a-1))が、0.5以上3以下である請求項1~6のいずれか1項に記載の泡吐出容器入り液体口腔用組成物。
- 成分(a-2)が、ヤシ油脂肪酸アミドアルキルベタイン、及びアルキルスルホベタインから選ばれる1種又は2種以上である請求項1~7のいずれか1項に記載の泡吐出容器入り液体口腔用組成物。
- 成分(X)の含有量が、0.1質量%以上2質量%以下である請求項5~8のいずれか1項に記載の泡吐出容器入り液体口腔用組成物。
- 泡吐出容器が、吐出口を備えるスクイズ容器又はポンプ容器から選ばれるノンエアゾール容器である請求項1~9のいずれか1項に記載の泡吐出容器入り液体口腔用組成物。
- 泡吐出容器が備える吐出口から、泡吐出容器入り液体口腔用組成物を口腔内へ直接吐出して、吐出口を経由した泡吐出容器入り液体口腔用組成物を泡状で口腔内へ適用する、請求項1~10のいずれか1項に記載の泡吐出容器入り液体口腔用組成物の使用方法。
- 次の成分(A)、(B)並びに(C):
(A)N-アシルアミノ酸塩、アルキル硫酸エステル塩、アルキルリン酸塩、及びα-オレフィンスルホン酸塩から選ばれるアニオン界面活性剤(a-1)、並びに両性界面活性剤(a-2)から選ばれる1種又は2種以上の界面活性剤 合計で0.3質量%以上2.5質量%以下
(B)グリセリン、プロピレングリコール、ブチレングリコール、及び平均分子量1000以下のポリエチレングリコールから選ばれる1種又は2種以上のポリオール 合計で10質量%以上40質量%以下、並びに
(C)水 50質量%以上89質量%以下
を含有し、成分(a-1)の含有量が1.2質量%以下であるか、或いは成分(a-1)を含有せず、かつ成分(a-2)の含有量が0.25質量%以上1.5質量%以下であり、
さらに、エタノールの含有量が3質量%以下であり、研磨性紛体の含有量が0.5質量%以下であり、粘結剤の含有量が0.3質量%以下であり、ノニオン界面活性剤の含有量が1.2質量%以下であり、かつ20℃において固体の糖アルコールの含有量が5質量%以下である、泡状液体口腔用組成物。 - カチオン性殺菌剤、トリクロサン、及びイソプロピルメチルフェノールから選ばれる1種又は2種以上の殺菌剤の、口腔内における吸着促進剤である請求項12に記載の泡状液体口腔用組成物。
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WO2017104152A1 (ja) * | 2015-12-14 | 2017-06-22 | 花王株式会社 | 泡吐出容器入り液体口腔用組成物 |
JP2018104320A (ja) * | 2016-12-26 | 2018-07-05 | 花王株式会社 | 口腔用エアゾール剤 |
JP2018123086A (ja) * | 2017-02-01 | 2018-08-09 | 花王株式会社 | 泡吐出容器入り液体口腔用組成物 |
JP2019001741A (ja) * | 2017-06-14 | 2019-01-10 | 花王株式会社 | 泡吐出容器入り液体口腔用組成物 |
JP2019094274A (ja) * | 2017-11-20 | 2019-06-20 | 花王株式会社 | 泡吐出容器入り液体口腔用組成物 |
JP2019182752A (ja) * | 2018-04-03 | 2019-10-24 | 花王株式会社 | 液体口腔用組成物 |
JP2021167287A (ja) * | 2020-04-10 | 2021-10-21 | 花王株式会社 | 泡吐出容器入り液体口腔用組成物 |
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JP7158433B2 (ja) | 2020-04-10 | 2022-10-21 | 花王株式会社 | 泡吐出容器入り液体口腔用組成物 |
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