WO2015173427A3 - Composition a action rapide d'insuline comprenant un compose anionique substitue et un compose polyanionique - Google Patents

Composition a action rapide d'insuline comprenant un compose anionique substitue et un compose polyanionique Download PDF

Info

Publication number
WO2015173427A3
WO2015173427A3 PCT/EP2015/060820 EP2015060820W WO2015173427A3 WO 2015173427 A3 WO2015173427 A3 WO 2015173427A3 EP 2015060820 W EP2015060820 W EP 2015060820W WO 2015173427 A3 WO2015173427 A3 WO 2015173427A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
rapid
substituted anionic
acting insulin
insulin composition
Prior art date
Application number
PCT/EP2015/060820
Other languages
English (en)
Other versions
WO2015173427A4 (fr
WO2015173427A2 (fr
Inventor
Olivier Soula
Richard Charvet
Bertrand Alluis
Original Assignee
Adocia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adocia filed Critical Adocia
Priority to EP15726556.2A priority Critical patent/EP3142686A2/fr
Publication of WO2015173427A2 publication Critical patent/WO2015173427A2/fr
Publication of WO2015173427A3 publication Critical patent/WO2015173427A3/fr
Publication of WO2015173427A4 publication Critical patent/WO2015173427A4/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)

Abstract

L'invention concerne une composition, sous forme de solution aqueuse, comprenant de l'insuline sous forme hexamèrique, au moins un composé anionique substitué de structure non saccharidique et au moins un composé polyanionique différent dudit composé anionique substitué.
PCT/EP2015/060820 2014-05-14 2015-05-15 Composition a action rapide d'insuline comprenant un compose anionique substitue et un compose polyanionique WO2015173427A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15726556.2A EP3142686A2 (fr) 2014-05-14 2015-05-15 Composition a action rapide d'insuline comprenant un compose anionique substitue et un compose polyanionique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1454313 2014-05-14
FR1454313 2014-05-14

Publications (3)

Publication Number Publication Date
WO2015173427A2 WO2015173427A2 (fr) 2015-11-19
WO2015173427A3 true WO2015173427A3 (fr) 2016-03-31
WO2015173427A4 WO2015173427A4 (fr) 2016-06-09

Family

ID=51688148

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2015/060820 WO2015173427A2 (fr) 2014-05-14 2015-05-15 Composition a action rapide d'insuline comprenant un compose anionique substitue et un compose polyanionique

Country Status (3)

Country Link
US (1) US9795678B2 (fr)
EP (1) EP3142686A2 (fr)
WO (1) WO2015173427A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2919804B1 (fr) 2012-11-13 2018-01-31 Adocia Formulation à action rapide d'insuline comprenant un composé anionique substitué
AR102869A1 (es) 2014-12-16 2017-03-29 Lilly Co Eli Composiciones de insulina de rápida acción
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
EP3377038A1 (fr) * 2015-11-16 2018-09-26 Adocia Composition a action rapide d'insuline comprenant un compose anionique substitue et un compose polyanionique
GB201607918D0 (en) 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
WO2018153506A1 (fr) 2017-02-22 2018-08-30 Adocia Composition d'insuline à action rapide contenant un sel d'acide citrique
CN110662551B (zh) * 2017-06-01 2023-07-18 伊莱利利公司 速效胰岛素组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0093551A2 (fr) * 1982-04-30 1983-11-09 Ajinomoto Co., Inc. Composition pharmaceutique
WO2013021143A1 (fr) * 2011-08-10 2013-02-14 Adocia Solution injectable d'au moins une insuline basale
WO2013064787A1 (fr) * 2011-11-02 2013-05-10 Adocia Formulation à action rapide d'insuline comprenant un oligosaccharide

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2387201A (en) 1942-01-12 1945-10-16 Bonneville Ltd Mono-acyl ethylene diamines
US2847385A (en) 1954-10-07 1958-08-12 Ohio Commw Eng Co Detergent-soil suspending composition containing carboxymethyl dextran
IT1053718B (it) 1973-04-04 1981-10-10 Zambeletti Spa L Metodo per prolungare l azione di farmaci attraverso la formazione di composti mcromolecolari
US4006059A (en) 1974-07-29 1977-02-01 Purdue Research Foundation Hydrophobic noncovalent binding of proteins to support materials
US4011137A (en) 1974-08-26 1977-03-08 Standard Brands Incorporated Process for producing dextrose using mixed immobilized enzymes
US4126628A (en) 1977-03-28 1978-11-21 Canadian Patents And Development Limited Acylation of amino acids
JPS53137911A (en) 1977-05-06 1978-12-01 Showa Denko Kk Preparation of n-(alpha-hydroxyalkanoyl)-peptides
US4438029A (en) 1978-01-19 1984-03-20 Research Corporation Synthetic peptides
AU550068B2 (en) 1981-03-10 1986-02-27 Novo Nordisk A/S Zinc insulin stabilized with calcium or magnesium salts
DE3482551D1 (de) 1983-10-26 1990-07-26 Kanebo Ltd Proteinhaltiges emulgiermittel, dessen herstellung und dieses enthaltende emulgierte kosmetische zusammensetzung.
JPS61176532A (ja) 1985-01-30 1986-08-08 Green Cross Corp:The プラスミノ−ゲンアクチベ−タ−前駆体の安定化方法
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
PL149145B1 (en) 1986-12-17 1990-01-31 The method of obtaining of symmetrical diamides of citric acid
WO1988006599A1 (fr) 1987-02-25 1988-09-07 Novo Industri A/S Nouveaux derives d'insuline
DK111489D0 (da) 1989-03-08 1989-03-08 Novo Nordisk As Peptider
JPH03153653A (ja) 1989-11-10 1991-07-01 Kuraray Co Ltd Ｎ―（１―アルコキシカルボニルスチリル）フマルアミド酸およびその製造方法
AU641721B2 (en) 1989-12-21 1993-09-30 Novo Nordisk A/S Insulin preparations containing nicotinic acid or nicotinamide
CA2035248A1 (fr) 1990-02-06 1991-08-07 Shang-Ren Wu Composes de carbamate de vinyle eet compositions detergentes renfermant ce compose
AU653026B2 (en) 1991-06-07 1994-09-15 Teikoku Seiyaku Kabushiki Kaisha Physiologically active polypeptide-containing pharmaceutical composition
US5310937A (en) 1991-06-10 1994-05-10 American Cyanamid Company 2,5-dioxo-3-pyrroline-1-acetanilide fungicidal agents and method for the preparation thereof
US5204366A (en) 1991-06-10 1993-04-20 American Cyanamid Company 2,5-dioxo-3-pyrroline-1-acetanilide fungicidal agents, compositions and method for use thereof
NZ260933A (en) 1993-07-16 1996-07-26 Hercules Inc Cation-complexed polysaccharides; use in foods and pharmaceuticals
JPH0782225A (ja) 1993-09-14 1995-03-28 Fuji Photo Film Co Ltd アミノ酸誘導体及びその用途
JP3414539B2 (ja) 1994-05-11 2003-06-09 有限会社ドット 経鼻吸収用組成物
US5547929A (en) 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
KR100236393B1 (ko) 1996-02-02 1999-12-15 나까니시 히로유끼 사람성장호르몬을 함유하는 의약제제
AUPO066096A0 (en) 1996-06-26 1996-07-18 Peptide Delivery Systems Pty Ltd Oral delivery of peptides
DE69924232D1 (de) 1998-01-09 2005-04-21 Novo Nordisk As Stabilisierte insulin-zubereitungen
FR2781485B1 (fr) 1998-07-21 2003-08-08 Denis Barritault Polymeres biocompatibles leur procede de preparation et les compositions les contenant
US6991798B1 (en) 1998-08-07 2006-01-31 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
AU3841500A (en) 1999-04-22 2000-11-10 Sankyo Company Limited Resin-bearing ketoamides and process for the preparation thereof
US7115663B2 (en) 2000-09-06 2006-10-03 Emisphere Technologies, Inc. Cyanophenoxy carboxylic acid compounds and compositions for delivering active agents
EP1345629A2 (fr) 2000-12-29 2003-09-24 Advanced Inhalation Research, Inc. Particules a liberation prolongee destinees a etre inhalees
US20020141946A1 (en) 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
GB0119665D0 (en) 2001-08-10 2001-10-03 Isis Innovation Conjugates
CA2471144C (fr) 2002-01-09 2011-06-07 Emisphere Technologies, Inc. Polymorphes de 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate de sodium
AU2003291867A1 (en) 2002-12-03 2004-06-23 Biomep Inc. Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex
US7297690B2 (en) 2003-02-24 2007-11-20 Japan Science And Technology Agency Fluorescent lanthadine complex
DE602004029630D1 (de) 2003-03-04 2010-12-02 Technology Dev Co Ltd Injizierbare Insulinzubereitung mit Langzeitwirkung und Verfahren zur dessen Herstellung und Verwendung
EP1626653B1 (fr) 2003-04-22 2007-09-19 Biodel, Inc. Disque pour nettoyer et hydrater la peau
PT103003A (pt) 2003-08-04 2005-02-28 Inst Superior Tecnico Novos inibidores de metalo-enzimas com potencial aplicacao em medicina
CN100372862C (zh) 2003-11-05 2008-03-05 天津和美生物技术有限公司 具有抗癌活性的阿霉素衍生物及其制备方法和应用
DE10355251A1 (de) 2003-11-26 2005-06-23 Merck Patent Gmbh Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor
AU2005209199B2 (en) 2004-01-16 2008-09-11 Biodel Inc. Sublingual drug delivery device
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US20080248999A1 (en) 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
ES2398318T3 (es) 2004-03-12 2013-03-15 Biodel, Inc. Composiciones de suministro de fármacos de acción rápida
US20080096800A1 (en) 2004-03-12 2008-04-24 Biodel, Inc. Rapid mucosal gel or film insulin compositions
FR2914305B1 (fr) 2007-03-29 2009-07-03 Proteins & Peptides Man Dextran fonctionnalise par des amino-acides hydrophobes.
FR2891149B1 (fr) 2005-09-26 2007-11-30 Biodex Sarl Composition pharmaceutique a action cicatrisante comprenant un derive de dextrane soluble et un facteur de croissance derive des plaquettes.
US20070244467A1 (en) 2005-09-28 2007-10-18 Biodel, Inc., State Of Incorporation Delaware Self-Filling Two Chamber Injectable Device
US20070086952A1 (en) 2005-09-29 2007-04-19 Biodel, Inc. Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
JP2007177182A (ja) 2005-12-28 2007-07-12 Dai Ichi Kogyo Seiyaku Co Ltd 乳化重合用乳化剤、ポリマーエマルションの製造方法及びポリマーエマルション
JP2007177185A (ja) 2005-12-28 2007-07-12 Dai Ichi Kogyo Seiyaku Co Ltd 乳化重合用乳化剤、ポリマーエマルションの製造方法及びポリマーエマルション
IL172896A0 (en) 2005-12-29 2006-06-11 Yeda Res & Dev Cxcr4 inhibition
WO2007098058A2 (fr) 2006-02-16 2007-08-30 Biodel, Inc. Procédé et dispositif d'administration sublinguale de médicaments par ionophorèse
JP2009532552A (ja) 2006-04-07 2009-09-10 アドシア 二官能化された多糖類
EP2012817A2 (fr) 2006-04-12 2009-01-14 Biodel, Inc. Formulations de combinaison d'insuline à action prolongée et à action rapide
US20120041079A1 (en) 2006-09-26 2012-02-16 Adocia Dextran functionalized by hydrophobic amino acids
WO2008062466A2 (fr) 2006-10-13 2008-05-29 Reliance Life Sciences Pvt. Ltd. Nouveaux agents chimiothérapeutiques contre l'inflammation et le cancer
GB0700523D0 (en) 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
WO2008152106A1 (fr) 2007-06-13 2008-12-18 Novo Nordisk A/S Formulation pharmaceutique contenant un dérivé d'insuline
FR2919188B1 (fr) 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
FR2927900B1 (fr) 2008-02-27 2010-09-17 Clariant Specialty Fine Chem Procede de preparation d'alpha-aminoacetals optiquement actifs.
WO2009127940A1 (fr) 2008-04-14 2009-10-22 Adocia Composition osteogenique comprenant un complexe facteur de croissance/polymere amphiphile un sel soluble de cation e un support organique
WO2009136500A1 (fr) 2008-05-07 2009-11-12 東洋紡績株式会社 L-succinyl aminoacylase et procédé de production d'un acide l-amino au moyen de cette dernière
FR2934999B1 (fr) 2008-08-13 2011-07-29 Adocia Polysaccharides fonctionnalises par des derives du tryptophane
WO2010028055A1 (fr) 2008-09-02 2010-03-11 Biodel, Inc. Insuline dotée d’un profil de libération basal
FR2940802A1 (fr) 2008-10-10 2010-07-09 Adocia Complexe entre l'insuline humaine et un polymere amphiphile et utilisation de ce complexe pour la preparation d'une formulation d'insuline humaine rapide.
BRPI0913684A2 (pt) 2008-09-26 2015-10-20 Adocia complexo composto por um polissacarídeo substituído por um triptofano ou um derivado de triptofano a partir de uma proteína ligadora à heparina, composição farmacêutica e seus usos
WO2010037180A1 (fr) 2008-10-03 2010-04-08 Glycan Biosciences Pty Ltd Conjugués d’oligosaccharides anioniques
FR2936800B1 (fr) 2008-10-06 2010-12-31 Adocia Polysaccharide comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe
US8759322B2 (en) 2008-11-05 2014-06-24 National University Corporation Tokyo Medical And Dental University Hyaluronic acid derivative and pharmaceutical composition thereof
FR2948573B1 (fr) 2009-07-31 2011-11-18 Adocia Nouvelle forme d'administration de complexes de proteines osteogeniques
US8728771B2 (en) 2008-12-11 2014-05-20 Toyo Boseki Kabushiki Kaisha L-succinylaminoacylase and process for producing L-amino acid using it
FR2944448B1 (fr) 2008-12-23 2012-01-13 Adocia Composition pharmaceutique stable comprenant au moins un anticorps monodonal et au moins un polysacharide amphiphile comprenant des substituants derives d'alcools hydrofobes ou d'amines hydrophobes.
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
FR2980796B1 (fr) 2011-09-30 2014-07-04 Adocia Oligosaccharides fonctionnalises
FR2943538B1 (fr) 2009-03-27 2011-05-20 Adocia Formulation a action rapide d'insuline recombinante humaine
US20120094902A1 (en) 2009-03-27 2012-04-19 Adocia Fast-acting insulin formulation
US9018190B2 (en) 2009-03-27 2015-04-28 Adocia Functionalized oligosaccharides
CN101920019B (zh) 2009-06-10 2012-06-06 浙江中医药大学 亲水性聚合物-葛根素特异性缀合的非溶血性缀合物
PT2612677E (pt) 2009-06-26 2015-09-10 Novo Nordisk As Preparação compreendendo insulina, nicotinamida e arginina
FR2958646B1 (fr) 2010-04-07 2012-05-18 Adocia Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive d'acide hydrophobe.
FR2958647B1 (fr) 2010-04-08 2013-08-23 Adocia Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive hydrophobe porte par un spacer au moins trivalent.
CN102834117B (zh) 2010-02-09 2015-11-25 阿道恰公司 通过至少两个由至少三价的间隔物所携带的疏水基团进行官能化的阴离子多糖
US8476238B2 (en) 2010-06-29 2013-07-02 Mycomagic Biotechnology Co., Ltd. Uses of an immunomodulatory protein (GMI) from Ganoderma microsporum
WO2012002450A1 (fr) 2010-06-30 2012-01-05 積水メディカル株式会社 D-succinylase et procédé de production d'un acide d-aminé l'utilisant
EP2590667A4 (fr) 2010-07-07 2013-11-27 Biodel Inc Compositions et procédés pour la modulation de la pharmacocinétique et de la pharmacodynamie de l'insuline
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
JP5903298B2 (ja) 2011-03-14 2016-04-13 東洋紡株式会社 Ｎ−サクシニル−ｄｌ−アミノ酸に対する向上されたｄ体選択性を有する改変型ｄ−サクシニラーゼ
WO2012153070A1 (fr) 2011-05-10 2012-11-15 Adocia Oligosaccharides fonctionnalisés
WO2012153071A2 (fr) 2011-05-10 2012-11-15 Adocia Polysaccharides à degré de fonctionnalisation modulable
CN103561862A (zh) 2011-05-18 2014-02-05 三菱瓦斯化学株式会社 吸氧剂
US20130231281A1 (en) 2011-11-02 2013-09-05 Adocia Rapid acting insulin formulation comprising an oligosaccharide
EP2919804B1 (fr) 2012-11-13 2018-01-31 Adocia Formulation à action rapide d'insuline comprenant un composé anionique substitué
JP2015010075A (ja) 2013-07-01 2015-01-19 学校法人神戸学院 γ−グルタミルシクロトランスフェラーゼ阻害剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0093551A2 (fr) * 1982-04-30 1983-11-09 Ajinomoto Co., Inc. Composition pharmaceutique
WO2013021143A1 (fr) * 2011-08-10 2013-02-14 Adocia Solution injectable d'au moins une insuline basale
WO2013064787A1 (fr) * 2011-11-02 2013-05-10 Adocia Formulation à action rapide d'insuline comprenant un oligosaccharide

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KALRA SANJAY ET AL: "Ultra-fast acting insulin analogues.", RECENT PATENTS ON ENDOCRINE, METABOLIC & IMMUNE DRUG DISCOVERY 2014, vol. 8, no. 2, 2014, pages 117 - 123, XP009183310, ISSN: 1872-2148 *
MONICA Z. MENZENSKI ET AL: "Self-assembly of supramolecular nanostructures from phenylalanine derived bolaamphiphiles", NEW JOURNAL OF CHEMISTRY, vol. 31, no. 9, 1 January 2007 (2007-01-01), pages 1674, XP055210714, ISSN: 1144-0546, DOI: 10.1039/b702586f *
R. MARCHELLI ET AL: "Chiral aminoacid containing acyclic ligands - II. Complexation of alkaline earth cations", TETRAHEDRON, vol. 38, no. 14, 1 January 1982 (1982-01-01), pages 2061 - 2067, XP055210711, ISSN: 0040-4020, DOI: 10.1016/0040-4020(82)85152-1 *
T. LODI ET AL: "Chiral aminoacid containing acyclic ligands-I. Syntheses and conformations", TETRAHEDRON, vol. 38, no. 14, 1 January 1982 (1982-01-01), pages 2055 - 2060, XP055210709, ISSN: 0040-4020, DOI: 10.1016/0040-4020(82)85151-X *

Also Published As

Publication number Publication date
US20160082106A1 (en) 2016-03-24
WO2015173427A4 (fr) 2016-06-09
WO2015173427A2 (fr) 2015-11-19
US9795678B2 (en) 2017-10-24
EP3142686A2 (fr) 2017-03-22

Similar Documents

Publication Publication Date Title
PL3577110T3 (pl) Związki podstawione 8-oksetan-3-ylo-3,8-diazabicyklo[3.2.1]oktan-3-ylem jako inhibitory hiv
WO2015173427A3 (fr) Composition a action rapide d'insuline comprenant un compose anionique substitue et un compose polyanionique
WO2016094810A3 (fr) Compositions de cannabinoïdes microencapsulées
WO2016040248A3 (fr) Compositions détergentes contenant un tensioactif ramifié
WO2015082046A3 (fr) Oxépines substituées
MX2016016666A (es) Derivados de acido boronico y usos terapeuticos de los mismos.
MX2016015093A (es) Derivados de acido boronico y sus usos terapeuticos.
PH12015500900A1 (en) A stabilized pemetrexed formulation
WO2015142001A3 (fr) Composé doté d'une action cardiotonique et composition pharmaceutique permettant de prévenir ou de traiter l'insuffisance cardiaque et contenant ledit composé
PH12015502755A1 (en) Insulin glargine / lixisenatide fixed ratio formulation
PH12017501084A1 (en) Insulin glargine/lixisenatide fixed ratio formulation
WO2015063416A3 (fr) Compositions stables de poly (3,4-ethylenedioxythiophene) et de stabilisants anioniques a acidité limitée
GEP201706760B (en) Novel abexinostate salt, associated crystalline form, preparation method thereof and the pharmaceutical compositions containing same
HUE062561T2 (hu) Legalább két eltérõ nanorészecskéket és egy gyógyászati vegyületet kombináló gyógyászati készítmény, annak elõállítása és alkalmazásai
EP3363803B8 (fr) Composé d'acide borique peptoïde à base d'urée, composition pharmaceutique contenant ce composé, procédé de préparation et utilisations de celui-ci
MX366499B (es) Composicion farmaceutica liquida.
WO2015104720A3 (fr) Compositions parentérales de bendamustine
EP3476850A4 (fr) Composé d'acide borique substitué, composition pharmaceutique le comprenant et son application
WO2014105777A8 (fr) Sel de dichlohydrate de cobicistat
WO2016020408A3 (fr) Composés pour prévenir l'ototoxicité
WO2015044434A3 (fr) Fluoro-9-méthyl-β-carboline
WO2015018567A3 (fr) Formulation contenant de l'éthanolamide caprylique et/ou de l'éthanolamide caprique en combinaison avec un agent tensioactif
WO2017087914A3 (fr) Biocapteurs d'urée et leurs utilisations
WO2017079403A3 (fr) Nanoparticules polymères
EP3283060A4 (fr) Compositions, composés bolaamphiphiles, et leurs utilisations

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15726556

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2015726556

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2015726556

Country of ref document: EP