WO2014035206A3 - 색전용 마이크로스피어의 제조방법 및 약물 함유 나노수송체가 결합된 마이크로스피어의 제조방법 - Google Patents

색전용 마이크로스피어의 제조방법 및 약물 함유 나노수송체가 결합된 마이크로스피어의 제조방법 Download PDF

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WO2014035206A3
WO2014035206A3 PCT/KR2013/007867 KR2013007867W WO2014035206A3 WO 2014035206 A3 WO2014035206 A3 WO 2014035206A3 KR 2013007867 W KR2013007867 W KR 2013007867W WO 2014035206 A3 WO2014035206 A3 WO 2014035206A3
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microspheres
drug
present
emboli
bound
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PCT/KR2013/007867
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English (en)
French (fr)
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WO2014035206A2 (ko
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이재휘
곽병국
김형민
이가현
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중앙대학교 산학협력단
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Priority claimed from KR1020120096589A external-priority patent/KR101395956B1/ko
Priority claimed from KR1020120096590A external-priority patent/KR101440681B1/ko
Application filed by 중앙대학교 산학협력단 filed Critical 중앙대학교 산학협력단
Priority to EP13833842.1A priority Critical patent/EP2891485B1/en
Priority to JP2015529687A priority patent/JP5957610B2/ja
Priority to US14/424,988 priority patent/US20150224221A1/en
Publication of WO2014035206A2 publication Critical patent/WO2014035206A2/ko
Publication of WO2014035206A3 publication Critical patent/WO2014035206A3/ko

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A—HUMAN NECESSITIES
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract

본 발명은 동결건조된 색전용 마이크로스피어의 회복성 최적화 공정 및 약물 함유 나노수송체가 결합된 키토산 마이크로스피어에 관한 것으로, 보다 구체적으로는 마이크로스피어의 안정된 보관을 위한 동결건조 처리 전에 동결건조 보호제로 트레할로스(trehalose)를 첨가하고, 동결건조 처리된 마이크로스피어를 와동시켜 재수화하는 회복성 최적화 공정 및 약물/키토산의 비율에 따라서 약물 함유 나노수송체가 결합된 키토산 마이크로스피어로부터 방출되는 약물의 양이 조절되므로, 정밀하게 약물 방출 조절이 가능하도록 한 마이크로스피어 및 이의 제조방법에 관한 것이다. 본 발명에 따른 최적화 공정을 이용하면, 색전용 마이크로스피어의 동결건조 처리 후에도 물리적 성질, 형태, 및 약물 방출정도를 유지할 수 있는 장점이 있으며, 본 발명에 따른 약물 함유 나노수송체가 결합된 키토산 마이크로스피어는, 혈관 내에서 안정적으로 색전을 일으키며, 약물의 방출이 정밀하게 조절되므로 항암치료에 사용될 수 있다.
PCT/KR2013/007867 2012-08-31 2013-08-30 색전용 마이크로스피어의 제조방법 및 약물 함유 나노수송체가 결합된 마이크로스피어의 제조방법 WO2014035206A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP13833842.1A EP2891485B1 (en) 2012-08-31 2013-08-30 Method for preparing microspheres for emboli, and method for preparing microspheres to which drug-containing carrier is bound
JP2015529687A JP5957610B2 (ja) 2012-08-31 2013-08-30 塞栓用のミクロスフェアの製造方法及び薬物含有ナノ輸送体が結合されたミクロスフェアの製造方法
US14/424,988 US20150224221A1 (en) 2012-08-31 2013-08-30 Method for preparing microspheres for emboli, and method for preparing microspheres to which drug-containing carrier is bound

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1020120096589A KR101395956B1 (ko) 2012-08-31 2012-08-31 약물 함유 나노수송체가 결합된 키토산 색전미세구 및 이의 제조방법
KR10-2012-0096590 2012-08-31
KR10-2012-0096589 2012-08-31
KR1020120096590A KR101440681B1 (ko) 2012-08-31 2012-08-31 색전용 마이크로스피어의 제조방법

Publications (2)

Publication Number Publication Date
WO2014035206A2 WO2014035206A2 (ko) 2014-03-06
WO2014035206A3 true WO2014035206A3 (ko) 2014-04-24

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Application Number Title Priority Date Filing Date
PCT/KR2013/007867 WO2014035206A2 (ko) 2012-08-31 2013-08-30 색전용 마이크로스피어의 제조방법 및 약물 함유 나노수송체가 결합된 마이크로스피어의 제조방법

Country Status (4)

Country Link
US (1) US20150224221A1 (ko)
EP (1) EP2891485B1 (ko)
JP (1) JP5957610B2 (ko)
WO (1) WO2014035206A2 (ko)

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