WO2014006983A1 - Composition d'agent de pousse des cheveux - Google Patents

Composition d'agent de pousse des cheveux Download PDF

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Publication number
WO2014006983A1
WO2014006983A1 PCT/JP2013/063559 JP2013063559W WO2014006983A1 WO 2014006983 A1 WO2014006983 A1 WO 2014006983A1 JP 2013063559 W JP2013063559 W JP 2013063559W WO 2014006983 A1 WO2014006983 A1 WO 2014006983A1
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Prior art keywords
hair
salicylate
mass
component
extract
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PCT/JP2013/063559
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English (en)
Japanese (ja)
Inventor
利江 廣畠
青野　恵
俊輔 廣島
恭史 柿澤
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ライオン株式会社
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Priority to JP2014523635A priority Critical patent/JP6179513B2/ja
Priority to KR1020147020877A priority patent/KR101891509B1/ko
Priority to CN201380035413.7A priority patent/CN104470492A/zh
Publication of WO2014006983A1 publication Critical patent/WO2014006983A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to a hair restorer composition capable of feeling both refreshing feeling and warm feeling.
  • the hair-growth effect is usually obtained by continuous use of a hair-growth nourishing agent over a long period of time, but none of the conventional hair-growth agents can achieve an effect when used once, leading to long-term use. There was no problem.
  • the present invention has been made in view of the above circumstances, and even when applied once, the scalp can be provided with a sufficient feeling of refreshment and warmth, can improve blood flow, and can be used over a long period of time.
  • An object of the present invention is to provide a hair restorer composition excellent in hair growth effect (prevention of hair loss, promotion of hair growth) due to an active ingredient at the time.
  • the inventors of the present invention have (B) a specific salicylic acid in (B) a specific hair-recovery composition containing (A) a hair-growth active ingredient, (D) ethanol, and (E) purified water.
  • a derivative is combined with (C) a specific refreshing agent and blended at a specific ratio, a refreshing feeling is felt immediately after application to the scalp.
  • the refreshing feeling weakens and the warming feeling becomes stronger immediately after that, it is found that the balance between the refreshing feeling and the warm feeling can give the user a high satisfaction that has never been seen before, It has been found that the blood flow in the scalp can be sufficiently increased because the warm feeling continues.
  • the warm feeling obtained in this way is felt in a small amount compared to extracts such as chili pepper tincture that have been used as a conventional warming ingredient, and is not accompanied by irritation such as chili pepper tincture. It was found to be a feeling and the present invention was made.
  • the present invention provides the following hair restorer composition.
  • A 6-benzylaminopurine, pentadecanoic acid glyceride, minoxidil, capronium chloride, t-flavanone and hypericum extract
  • B glycolic salicylate, methyl salicylate, dipropylene glycol salicylate, octyl salicylate, salicylic acid A salicylic acid derivative selected from phenyl and homomenthyl salicylate
  • C a refreshing agent selected from 1-menthol, menthyl glyceryl ether and mint oil
  • D ethanol
  • E A hair restorer composition containing purified water and having a mass ratio of 0.5 to 50 represented by (B) / (C).
  • the hair restorer composition of the present invention has a strong refreshing feeling immediately after application to the scalp, and immediately after that, the refreshing feeling weakens and the warmth becomes stronger. High satisfaction can be given to the person. Moreover, since this warm feeling continues, the blood flow volume of a scalp can fully be raised. Moreover, the warm sensation by the composition of the present invention is an unprecedented warm sensation that does not involve irritation such as chili pepper tincture, and can be used over a long period of time to prevent hair loss and promote hair growth.
  • the composition of the present invention comprises: (A) hair-growth active ingredient, (B) a salicylic acid derivative, (C) freshener, (D) ethanol, (E) A refreshing / warm hair-growing composition containing purified water.
  • the refreshing / warm hair-growing composition refers to a hair-growing composition that can first feel a refreshing feeling and then a warm feeling after being applied to the scalp. Specifically, it is 0 to 5 minutes after application, especially 0 minutes to less than 3 minutes after starting application, and it is 3 to 7 minutes after application, particularly 3 to 5 minutes after application. Preferably there is.
  • the component (A) used in the present invention is a known hair-growth active ingredient having a hair-growth effect (prevention of hair loss, hair growth promotion).
  • a hair-growth active ingredient having a hair-growth effect (prevention of hair loss, hair growth promotion).
  • 6-benzylaminopurine, pentadecanoic acid glyceride, minoxidil, capronium chloride, t -Flavanone, hypericum extract and the like can be used alone or in appropriate combination of two or more.
  • 6-benzylaminopurine, pentadecanoic acid glyceride and minoxidil are preferable, and from the viewpoint of hair loss improvement and hair growth promoting effect. More preferred are 6-benzylaminopurine and pentadecanoic acid glycerides.
  • the blending amount of the component (A) is preferably 0.1 to 5% by mass, more preferably 0.5 to 3% by mass with respect to the total amount of the composition from the viewpoint of hair loss improvement and hair growth promoting effect. By setting it as the said range, hair loss improvement and the hair growth promotion effect increase more, and it can suppress that the background becomes sticky at the time of application
  • (B) Salicylic acid derivative By combining a salicylic acid derivative with a refreshing agent of the following component (C) at a predetermined ratio, surprisingly, the scalp first has a refreshing sensation, then a refreshing sensation and a warm sensation. It can be given in a smaller amount than conventional warming ingredients such as chili pepper tincture, and without causing irritation, a high warming effect can be obtained, and the warming imparting effect on the scalp and the blood flow improvement effect are dramatically improved improves.
  • the component (B) include salicylic acid derivatives such as glycol salicylate, methyl salicylate, dipropylene glycol salicylate, octyl salicylate, phenyl salicylate, and homomenthyl salicylate. These can be used singly or in appropriate combination of two or more, but salicylate glycol, methyl salicylate and dipropylene glycol salicylate are preferred, more preferably from the viewpoint of imparting warmth and improving blood flow. Salicylic acid glycol.
  • the blending amount of the component (B) is preferably 0.01 to 5% by mass, more preferably 0.3 to 2% by mass with respect to the total amount of the composition from the viewpoint of imparting warmth and improving blood flow. . If it is less than 0.01% by mass, the imparting of warmth and the effect of improving blood flow may be inferior, and if it exceeds 5% by mass, the background may be sticky, the improvement of blood flow and the effect of imparting warmth may be inferior.
  • component (C) Coolant By blending the component (C) together with the component (B), as described above, a refreshing feeling and a warm feeling can be imparted to the scalp, and the effect of improving the blood flow can be remarkably enhanced.
  • the component (C) include l-menthol, menthyl glyceryl ether, mint oil and the like. These can be used singly or in appropriate combination of two or more, but l-menthol is preferable from the viewpoint of imparting warmth and improving blood flow.
  • the blending amount of the component (C) is preferably 0.01 to 5% by mass and more preferably 0.1 to 2% by mass with respect to the total amount of the composition from the viewpoint of imparting warmth and improving blood flow. If it is less than 0.01% by mass, the effect of imparting warmth and the effect of improving blood flow may be inferior, and if it exceeds 5% by mass, the effect of imparting warmth may be inferior.
  • the blending ratio of the component (B) and the component (C) is (B) / (C), and the content ratio of the component (B) to the component (C) is improved in warmth and blood flow.
  • it is 0.5 to 50, preferably 1 to 50, more preferably 1.5 to 20, and further preferably 2.5 to 10.
  • this mass ratio is less than 0.5, the blood flow and warming effect are inferior, and when it exceeds 50, the warming and blood flow improving effect is poor.
  • ethanol examples include absolute ethanol and 95% by volume ethanol. From the viewpoint of imparting warmth to the scalp and improving blood flow, 55% by mass or more is preferable as absolute ethanol with respect to the total amount of the composition, and more preferably 60% by mass or more.
  • the upper limit is not particularly limited, but may be 85% by mass or less, particularly 80% by mass or less from the viewpoint of not stimulating a person with sensitive skin.
  • this compounding quantity is a compounding quantity containing the ethanol brought in from these extracts, when extracts, such as a plant extract, are mix
  • Purified water is preferably 12 to 43% by mass, more preferably 18 to 37% by mass, based on the total amount of the composition, from the viewpoint of imparting warmth and improving blood flow. By setting it within the above range, a warmer feeling can be felt and the blood flow can be further improved.
  • this compounding quantity is a compounding quantity containing the purified water brought in from these extracts, when extracts, such as a plant extract, are mix
  • the preferable blending ratio of the component (D) and the component (E) is the content of the component (D) with respect to the component (E) represented by (D) / (E) in terms of warmth and blood flow improvement.
  • the mass ratio is preferably 1.3 to 4.4, more preferably 1.4 to 4.
  • the hair-restoring agent composition of the present invention is particularly suitable for men and women because it has a feeling of use, has no stickiness, and is excellent in preventing hair loss. It is effective for women, because it can soften hair and show a large amount.
  • an extract (F) in addition to the components (A) to (E), an extract (F) can be blended in order to further improve warmth, blood flow and hair growth effect.
  • a shrimp extract, a loquat leaf extract, a red pepper tincture, etc. can be used individually by 1 type or in combination of 2 or more types as appropriate.
  • a pepper extract and a loquat leaf extract are more preferable because of lack of warmth and irritation.
  • Solvents used for extraction of these extracts are not particularly limited, but include polyhydric alcohols such as water, lower alcohols such as methanol, ethanol, propanol and isopropanol, 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin.
  • polyhydric alcohols such as water, lower alcohols such as methanol, ethanol, propanol and isopropanol, 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin.
  • ethers such as alcohol, ethyl ether and propyl ether, esters such as ethyl acetate and butyl acetate, polar organic solvents such as acetone and methyl ethyl ketone, physiological saline, and phosphate buffer.
  • a commercial item can be used as each extract of such (F) component.
  • Falco Rex Showa E Showa Extract 1.30% by mass (pure extract), water 69.45% by mass, absolute ethanol 29.25% by mass) (Ichimaru Falcos Co., Ltd.), Ginger tincture (1.00% by mass of ginger root extract (pure extract), 25.74% by mass of water, 73.26% by mass of absolute ethanol) (manufactured by Maruzen Pharmaceutical Co., Ltd.) and the like.
  • the loquat leaf extract is, for example, loquat extract-J (loan leaf extract 1.4% by mass (pure extract), water 49.3% by mass, absolute ethanol 49.3% by mass), loquat leaf extract CA (loan leaf extract). 1% by weight of extract (pure extract), 99% by weight of 1,3-butylene glycol), loquat extract BG-J (1.5% by weight of loquat leaf extract (pure extract), 49.25% by weight of water, 1% , 3-butylene glycol 49.25% by mass), loquat extract LA (0.96% by mass of loquat leaf extract (pure extract), 69.33% by mass of water, 29.71% by mass of absolute ethanol) (all of which are Maruzen Manufactured by Pharmaceutical Co., Ltd.), Falcolex Biwaleaf B (1.5% by mass of Biwa leaf extract (extracted extract), 49.25% by mass of water, 49.25% by mass of 1,3-butylene glycol), Falcolex Biwal
  • pepper tincture examples include chili pepper tincture (capsicum fruit extract 0.30% by mass (extracted pure), 99.7% by mass absolute ethanol) (manufactured by Maruzen Pharmaceutical Co., Ltd.).
  • the blending amount is 0. 0 as the pure extract with respect to the total amount of the composition in terms of hair loss improvement, warmth and blood flow improvement.
  • 0001 mass% or more is preferable, More preferably, it is 0.003 mass% or more. By setting it as 0.0001 mass% or more, a blood flow rate and a warm feeling can be improved more.
  • the upper limit is not particularly limited, but is preferably 0.07% by mass or less, more preferably 0.05% by mass or less, and particularly preferably 0.02% by mass or less as a pure extract from the point of not causing irritation.
  • 0.00003 mass% or more is preferable as an extract pure part, More preferably, it is 0.0009 mass% or more. A feeling of warmth can be improved more by setting it as 0.00003 mass% or more.
  • the upper limit is not particularly limited, but is preferably 0.015% by mass or less, particularly preferably 0.003% by mass or less from the viewpoint of not causing irritation.
  • the percutaneous absorption enhancer is a component that promotes absorption of (A) a hair-growth active ingredient from the skin, and also has an action of promoting blood flow, specifically, polyethylene glycol having an average molecular weight of 190 to 210.
  • polyethylene glycol 300 having an average molecular weight of 280 to 320 polyethylene glycol 400 having an average molecular weight of 380 to 420, polyethylene glycol 600 having an average molecular weight of 570 to 630, diisopropyl adipate, lecithin, myristyl lactate, lauryl lactate, ethyl lactate and the like And mono-, di- or triglycerides of medium chain fatty acids such as monocaprylic acid.
  • polyethylene glycol 300 having an average molecular weight of 280 to 320 and polyethylene glycol 400 having an average molecular weight of 380 to 420 are preferable from the viewpoint of hair loss improvement and blood flow.
  • the average molecular weight is measured by applying the test method (p1378) of polyethylene glycol 200 listed in the quasi-drug raw material standard 2006 (Pharmaceutical Daily).
  • the compounding quantity is 0.01 mass% or more from the point of hair loss improvement, the hair growth effect, and blood flow improvement with respect to the composition whole quantity, More preferably, it is 0.3 mass% or more. It is. By setting it as the said range, a blood flow rate can be improved more and the percutaneous absorption promotion effect can be heightened more.
  • the upper limit is not particularly limited, but is preferably 5% by mass or less, and particularly preferably 3% by mass or less from the viewpoint that stickiness does not occur in terms of use.
  • an optional component other than the above-mentioned components that are usually blended in the hair restorer composition is used alone or in combination of two or more, as long as the effects of the present invention are not impaired. Can do.
  • nonionic surfactants examples include nonionic surfactants, semipolar surfactants, amphoteric surfactants, anionic polymers, nonionic polymers, polyols other than the component (G), organic salts, humectants, tonic agents, Solubilizers, antioxidants such as dibutylhydroxytoluene and ⁇ -tocopherol, bactericides such as triclosan and trichlorocarban, viscosity modifiers such as fatty acid monoethanolamide and fatty acid diethanolamide, UV absorbers, antioxidants, protein derivatives Animal and plant extracts, anti-dandruff agents such as piroctone olamine and zinc pyrithione, anti-inflammatory agents such as dipotassium glycyrrhizinate, benzoic acid and salts thereof, parabens, preservatives such as caisson CG, citric acid, triethanolamine and the like pH adjusters, pearlizing agents such as ethylene glycol difatty acid esters, milk Agents
  • the hair restorer composition (cool feeling (cool feeling) / warm hair restorer composition) of the present invention can be widely used as a hair restorer, a hair nourishing agent, a blood circulation promoter, and a hair loss improving agent, and is particularly preferably used as a hair restorer. . In this case, it can be used for external use in the form of a hair-growth tonic, scalp essence, hair-growth spray, hair-growth hair gel or the like.
  • the hair restorer composition of the present invention can be obtained based on a conventional method by mixing the above essential components and optional components.
  • Examples of the container for filling the hair-restoring agent composition of the present invention include aluminum laminate tubes, EVAL tubes, aluminum tubes, glass-deposited plastic tubes, and the like, as well as dispenser containers and squeeze containers by mechanical or differential pressure, laminate film containers, A dropper container, a stick container, a bottle container, etc. are mentioned.
  • the laminated film of aluminum laminated tube usually has two or more layers, and the material is synthetic resin such as polyethylene, polyethylene terephthalate, polyester, biaxially stretched polypropylene, unstretched polypropylene, polyacrylonitrile, ethylene vinyl acetate copolymer, etc. It is preferably made of paper, aluminum-deposited plastic, or the like.
  • polyethylene, polypropylene, polyethylene terephthalate, polystyrene, polyvinyl chloride, ethylene-vinyl alcohol resin, acrylonitrile / styrene resin, ABS resin, polyamide, glass, etc. can be used in a single layer or in combination of two or more layers. .
  • Examples 1 to 56, Comparative Examples 1 to 5 A hair restorer composition having the composition shown in the following table was prepared according to a conventional method and evaluated by the following method. The results are also shown in the table.
  • surface the numerical value in () of polyoxyethylene tetraoleate (40) sorbit shows the average addition mole number of ethylene oxide.
  • the blending amount of (D) ethanol and (E) purified water indicates the total amount contained in the composition.
  • (D) ethanol is the quantity as absolute ethanol.
  • Components (A) to (C) are pure equivalents. In the case of extracts, the upper part is solid, and the lower part indicates the amount of pure extract.
  • Each composition of an Example and a comparative example was mix
  • Increasing rate of blood flow ⁇ (T1-T0) / T0 ⁇ ⁇ 100 (%) ⁇ Evaluation criteria> ⁇ : Blood flow increased by 30% or more and 50% or less than blank ⁇ ⁇ ⁇ : Blood flow increased by 20% or more but less than 30% than blank ⁇ : Blood flow increased by 15% or more but less than 20% than blank ⁇ : Blank Blood flow increased more than 10% but less than 15% more than ⁇ : Blood flow increased less than 10% or no change from blank
  • FIG. 1 shows a graph showing an example of how to feel cool and warm about one subject.
  • a broken line indicates a refreshing feeling and a solid line indicates a warm feeling.

Abstract

L'invention concerne une composition d'agent de pousse des cheveux comprenant : (A) un principe actif de pousse des cheveux choisi parmi la 6-benzylaminopurine, un glycéride d'acide pentadécanoïque, le minoxidil, le chlorure de carpronium, la t-flavanone et un extrait de millepertuis commun ; (B) un dérivé de l'acide salicylique choisi parmi le salicylate de glycol, le salicylate de méthyle, le salicylate de dipropylène glycol, le salicylate d'octyle, le salicylate de phényle et le salicylate d'homomenthyle ; (C) un agent de rafraîchissement choisi parmi le 1-menthol, le menthyl glycéryl éther et l'essence de menthe poivrée ; (D) de l'éthanol ; et de l'eau purifiée, le rapport en masse de la teneur représenté par (B)/(C) étant 1 à 50. Cette composition d'agent de pousse des cheveux est apte à conférer une sensation chaude suffisante au cuir chevelu même avec une application, permettant ainsi d'améliorer la circulation sanguine, et présente d'excellents effets de pousse des cheveux (empêche la perte des cheveux et favorise la pousse des cheveux) par le principe actif lorsqu'elle est utilisée pendant une période prolongée de temps.
PCT/JP2013/063559 2012-07-05 2013-05-15 Composition d'agent de pousse des cheveux WO2014006983A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2014523635A JP6179513B2 (ja) 2012-07-05 2013-05-15 育毛剤組成物
KR1020147020877A KR101891509B1 (ko) 2012-07-05 2013-05-15 육모제 조성물
CN201380035413.7A CN104470492A (zh) 2012-07-05 2013-05-15 生发剂组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012151423 2012-07-05
JP2012-151423 2012-07-05

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WO2014006983A1 true WO2014006983A1 (fr) 2014-01-09

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