WO2007074602A1 - Cosmetique pour le cuir chevelu et les cheveux - Google Patents

Cosmetique pour le cuir chevelu et les cheveux Download PDF

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Publication number
WO2007074602A1
WO2007074602A1 PCT/JP2006/323755 JP2006323755W WO2007074602A1 WO 2007074602 A1 WO2007074602 A1 WO 2007074602A1 JP 2006323755 W JP2006323755 W JP 2006323755W WO 2007074602 A1 WO2007074602 A1 WO 2007074602A1
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Prior art keywords
acid
hair
derivatives
scalp
extract
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PCT/JP2006/323755
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English (en)
Japanese (ja)
Inventor
Nobuyasu Satou
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Lion Corporation
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Publication date
Application filed by Lion Corporation filed Critical Lion Corporation
Priority to JP2007551869A priority Critical patent/JP5453715B2/ja
Publication of WO2007074602A1 publication Critical patent/WO2007074602A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin

Definitions

  • the present invention relates to a skin external preparation composition that promotes percutaneous absorption of an active ingredient for nourishing hair by applying it externally to scalp hair, and more specifically, improves the percutaneous absorption of an active ingredient for nourishing hair. Therefore, the present invention relates to a scalp hair cosmetic composition that exhibits a hair-restoring effect more effectively and has an excellent feeling during use.
  • Patent Document 1 Japanese Patent Laid-Open No. 4217926
  • a base of a transdermal absorption preparation contains nicergoline as an active ingredient
  • Patent Document 2 Japanese Patent Laid-Open No. 5-25046
  • Patent Document 3 Japanese Patent Laid-Open No.
  • Patent Document 1 Japanese Patent Laid-Open No. 4217926
  • Patent Document 2 JP-A-5-25046
  • Patent Document 3 Japanese Patent Laid-Open No. 2000-119195
  • Patent Document 4 Japanese Patent Laid-Open No. 4-145015
  • Patent Document 5 JP 2001-302462 A
  • Patent Document 6 JP-A-58-180407
  • the present invention improves the percutaneous absorption of active ingredients for nourishing hair by applying it externally to the scalp hair, and particularly has an effect of promoting hair growth and preventing hair loss by applying it externally to the scalp.
  • An object of the present invention is to provide a scalp hair cosmetic that is excellent in use feeling during use.
  • the present inventor has proposed that menthol and an amino acid-based nonionic surfactant promote the skin absorption of an active ingredient for nourishing hair, and combine these ingredients and the active ingredient for nourishing hair. It has been found that when a material is used, there is no stickiness and the feeling of use is excellent, and the present invention has been made.
  • the present invention provides:
  • One or more hair-growth active ingredients selected from the following (A) cell activator, (B) blood flow improving agent, (C) anti-inflammatory agent, (D) bactericidal agent and (E) local stimulant A scalp and hair cosmetic containing menthol and an amino acid-based nonionic surfactant of 0.01 to less than 3% by mass
  • A Cell activating agent: pantothenic acid and derivatives thereof, adenosine, bracente extract, photosensitizer, piotin, pentadecanoic acid glyceride, adenine and derivatives thereof, thymine and derivatives thereof, guanine and derivatives thereof, cytosine and derivatives thereof, uracil and derivatives thereof Derivatives, astilbine and its derivatives, and mono-trogoaiacol
  • B Blood flow improver: salty calp mouthpiece, vitamin E derivative, sempri extract, cephalanthin, nicotinamide, carrot extract and minoxidil
  • Anti-inflammatory agents glycyrrhetinic acid and its derivatives, and glycyrrhizic acid and its derivatives
  • (D) Fungicide Isopropylmethylphenol, salicylic acid, hinokitiol, benzalcoyl chloride, benzethonium chloride, trichlorocarbalide, zinc pyrithione, 1-hydroxy 2-pyridone compounds and their salts, and propolis
  • the hair-restoring hair is effective.
  • the percutaneous absorption of ingredients can be promoted, excellent hair growth can be demonstrated, and the scalp hair can improve the feeling of use of cosmetics.
  • FIG. 1 is a perspective view of a Franz diffusion cell used in the test of the present invention.
  • FIG. 2 is an explanatory diagram for explaining a test method using a Franz diffusion cell.
  • the hair-growth active ingredient of the present invention is selected from the following (A) cell activator, (B) blood flow improving agent, (C) anti-inflammatory agent, (D) fungicide, and (E) local stimulant power 1 type or 2 types or more.
  • (A) Cell activating agent pantothenic acid and its derivatives, adenosine, bracent extract, photosensitizer, piotin, pentadecanoic acid glyceride, adenine and its derivatives, thymine and its derivatives Derivatives, guanine and its derivatives, cytosine and its derivatives, uracil and its derivatives, istilbin and its derivatives, and mono-troguaiacol
  • Blood flow improver salty calp mouthpiece, vitamin E derivative, sempri extract, cephalanthin, nicotinamide, carrot extract and minoxidil
  • Anti-inflammatory agents glycyrrhetinic acid and its derivatives, and glycyrrhizic acid and its derivatives
  • (D) Fungicide Isopropylmethylphenol, salicylic acid, hinokitiol, benzalcoyl chloride, benzethonium chloride, trichlorocarbalide, zinc pyrithione, 1-hydroxy 2-pyridone compounds and their salts, and propolis
  • pantothenic acid such as pentadecanoic acid glyceride, pantothel alcohol, and non-tuethyl ether, and derivatives thereof, and adenosine are preferred.
  • vitamin E derivatives such as calp mouth-mume and tocopherol acetate, assembly extract, and nicotinamide are preferable.
  • the anti-inflammatory agent include glycyrrhetinic acid such as j8-glycyrrhetinic acid and stearyl glycyrrhetinic acid and derivatives thereof, glycyrrhizic acid, ammonium glycyrrhizinate, trisodium glycyrrhizinate, Glycyrrhizic acid and its derivatives such as dipotassium glycyrrhizinate and methyl glycyrrhizinate are preferred, and among them, ⁇ -darlicylretinoic acid and dipotassium glycyrrhizinate are preferred.
  • glycyrrhetinic acid such as j8-glycyrrhetinic acid and stearyl glycyrrhetinic acid and derivatives thereof
  • glycyrrhizic acid ammonium glyc
  • 1-hydroxy 2-pyridone compounds such as isopropylmethylphenol, salicylic acid, hinokitiol, zinc pyrithione, pyrotatone olamine, and salts thereof are preferable.
  • the amount of the scalp hair cosmetic composition of the cell-activating agent is usually 0.001 to 5.0 mass 0/0, 0.01 to 4.0 mass 0/0 force transducer preferred, more preferably 0.
  • the upper limit of the blending amount is more preferably 2.0% by mass or less.
  • the amount of the scalp hair cosmetic composition of the blood flow improving agent is usually 0.5 001-5. 0 wt 0/0, 0.01 to 2 . 0 mass 0/0 force transducer preferred, more preferably 0. 05 ⁇ : L 0 mass%. If the amount is too small, sufficient effects may not be obtained.
  • the amount of the scalp hair cosmetic composition of the anti-inflammatory agent is usually 0 001-2 0 mass 0/0, 0. 01 ⁇ :. . L 0 mass 0/0 force transducer preferred, more preferably 0.05 to 0.5 wt%. If the amount is too small, a sufficient effect may not be obtained, and if too much, it may be uneconomical.
  • the amount of scalp hair in I ⁇ fee fungicide is usually 0.00 1 to 2.0 mass 0/0, 0.005 to 1. 0 weight 0/0 force transducer preferred, more preferably 0.01 to 0.5 wt%. If the amount is too small, a sufficient effect may not be obtained.
  • the amount of the scalp hair cosmetic composition of topical stimulant is usually 0.00001 to 2 mass 0/0, 0.00005 to 0.5 mass 0 / 0 force is more preferable than a child force ⁇ is 0.0001-0. 1% by mass. If the amount is too small, sufficient effects may not be obtained.
  • the menthol (1 menthol) of the present invention is used as a transdermal absorption enhancer of a hair-growing active ingredient.
  • the blending amount of menthol in the scalp and hair cosmetic is usually 0.001-5 mass%, 0.01-2.0 mass% is more preferable, 0.05-: L 0 mass%. More preferably, it is 0.25 to: L 0% by mass. Within this range, the effect of improving the skin absorption and feeling of use of the active nourishing hair ingredient can be obtained.
  • amino acid-based nonionic surfactant of the present invention is used as a percutaneous absorption enhancer of a nourishing hair active ingredient.
  • amino acid-based surfactants include amino acid-based surfactants represented by the following general formulas (1) to (4), one type alone or a combination of two or more types as appropriate. Can be used.
  • I ⁇ CO is independently a straight chain or branched long chain acyl group having 8 to 22 carbon atoms
  • R 1 is a saturated or unsaturated monovalent hydrocarbon group.
  • R 2 is a cholesterol group.
  • Ester-forming residue, ester-forming residue of a linear or branched higher alcohol having 8 to 33 carbon atoms, and a, b and c are all 0 or independently a number of 1 to 30.
  • examples of the compound represented by the general formula (1) include dihexyl decyl lauroyl glutamate, dioctyl dodecyl stearoyl glutamate, dioctyl dodecyl lauroyl glutamate, and the like.
  • Examples of the compound represented by the general formula (2) include lauroyl glutamic acid polyoxyethylene octyldodecyl ether diester, lauroyl glutamic acid polyoxyethylene stearyl ether diester, and the like.
  • pyroglutamic acid isostearate polyoxyethylene cured Mashi oil etc. are mentioned.
  • Examples of the compound represented by the general formula (4) include glyceryl pyroglutamate oleate, and examples of the other amino acid-based surfactant include polyoxyethylene glyceryl isostearate pyrodartrate.
  • examples of the other amino acid-based surfactant include polyoxyethylene glyceryl isostearate pyrodartrate.
  • the compounding amount of the amino acid-based non-ionic surfactant in the scalp hair cosmetic composition is 0.01 to less than 3% by mass, and preferably 0.1 to 3% by mass. If the amount is too small, the effect of promoting the percutaneous absorption of the active hair nurturing component cannot be sufficiently exerted, and if it is too large, stickiness will occur during use.
  • the scalp and hair cosmetic composition of the present invention is further improved in the effect of promoting percutaneous absorption of an active nourishing hair ingredient by combining a polyhydric alcohol and a liquid ester oil at 25 ° C.
  • a polyhydric alcohol examples include polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, ethylene glycol glycol, diethylene glycol, triethylene glycol, pentanediol, isoprene glycol, and hexanediol. These may be used alone or in appropriate combination of two or more.
  • the blending amount in the scalp hair cosmetic is preferably 0.05 to 5% by mass, more preferably 0.1 to 3% by mass.
  • the blended amount in the scalp and hair cosmetic is preferably 0.01 to 20% by mass, more preferably 0.1 to 10% by mass. .
  • an optional component can be blended depending on the purpose of use within a range not impairing the effects of the present invention.
  • examples of such components include anti-androgen hormones, moisturizers, vitamins, amino acids, purified water, ethanol, celluloses, surfactants other than the amino acid nonionic surfactants, fats and oils, and polymers.
  • examples include rosin, coloring materials, fragrances, and UV absorbers.
  • surfactants other than the amino acid-based nonionic surfactant include, for example, glycerin fatty acid ester and its alkylene glycol adduct, polyglycerin fatty acid ester with alkylene glycol, propylene glycol fatty acid ester and alkylene thereof.
  • the fragrance used is similar to the fragrance and fragrance composition described in JP 2003-113019 A, when blending a fragrance composition. It is preferable that the fragrance composition is blended in an amount of 0.0001 to 50% by mass, more preferably 0.0001 to 30% by mass based on the total amount of the scalp and hair cosmetic.
  • the scalp hair cosmetic composition of the present invention can be prepared for both scalp and hair by mixing the above ingredients, and if necessary, ethanol and water (remainder) based on a conventional method. It is suitable as. Specifically, essence, tonic, hair cream, shampoo, rinse, conditioner, etc. can be used.
  • the dosage form should be a uniform solution, lotion, It can be prepared in the form of a leu, cream, aerosol, etc.
  • a compressed gas selected from butane, propane, isobutane, liquid petroleum gas, flammable gas that also has dimethyl ether power, nitrogen gas, oxygen gas, carbon dioxide gas, and nitrous oxide gas. It is possible to use the mixture.
  • the scalp hair cosmetic of the present invention is selected from the above (A) cell activator, (B) blood flow improving agent, (C) anti-inflammatory agent, (D) fungicide, and (E) local stimulant. It is suitable as a transdermal absorption enhancer comprising a mixture containing one or more active hair-growing ingredients, menthol, and an amino acid-based nonionic surfactant 0.1 to less than 3% by mass.
  • Hair growth tonics having the compositions shown in Tables 1 to 3 were prepared based on conventional methods, and the skin permeability and the feeling of use (no stickiness) of the active hair growth ingredients in the hair growth tonic were evaluated. The results are also shown in Tables 1-3.
  • Skin permeability was measured using a glass Franz diffusion cell as shown in FIG. A method for measuring the skin permeability of active ingredients using a fluff type diffusion cell is described with reference to FIGS.
  • a guinea pig (HARTLEY, female), back-exfoliated skin (5) (5cm x 5cm), and a stratum corneum side on a Franz diffusion cell (1) (effective diffusion membrane area of about 4cm 2 )
  • the donor (2) phase and scissors were fixed so that the dermis side was the receptor (3) phase.
  • the receptor (3) side was filled with physiological saline, and then kept at 32 ° C in a constant temperature layer while stirring with a stirrer (4).
  • the physiological saline inside was sampled. Quantify the active ingredients of nourishing hair in physiological saline
  • the amount of the above-mentioned active ingredient (the amount of skin permeation) in the receptor (3) phase was measured.
  • the relative value (%) of the permeation amount of each composition was calculated when the permeation amount of the ethanol solution (control) with the blending concentration of each active ingredient was 100%.
  • UV absorptiometer (measurement wavelength: 210-300nm)
  • Hinokitiol 0.1 ⁇ Glycyrrhetinic acid 1.0 Polyethylene glycol 3 ⁇ 0 0.1 0.1 Glyceride pentadecanoate 2.5 ft acid D L ⁇ Tocopherol 0.1 0.1 Dioctyldodecyl stearoyl glutamate 2.0
  • composition% Carbohydrate Chloride Mouth 0.1% Dicalcium glycyrrhizinate 0.5 Glycerin 0.1
  • Cephalanthin 0.2 Polyethylene glycol 600 2. 0 Carrot extract 1. ⁇ Sorbitan laurate 0.5 Pyroglutamate isostearic acid POE (40) Hardened castor oil 1.5 Ethyl oleate 0.1 Chenic acid 0.3 Sucrose lauric acid Ester 0.5 Fragrance * 0.1 Diisostearyl malate 1.5
  • composition% A Oil phase part
  • Carpronium chloride 0.05 Alcohol nicotinic acid 0.2 Minoxidi / Les 0.02 Monolauric acid glyceryl 0.4 Proplenic ricinole 0.5 Lauroylglutamic acid POE (5) Steryl ether diester 1.5 Polyethylene glycol 300 0.3 Pistol glutamic acid isostearic acid POE (30) Hardened castor oil 0.5 Triglyceryl tri-2-ethylhexylate 0.5
  • the scalp hair cosmetics of Examples 24 to 38 were excellent in the feeling of use in which the skin permeability of the nourishing hair component was very sticky.
  • LGOD-2 NIPPON EMAL YON OTACILDOTE 'SIL-TERSI' ESTER

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Abstract

Selon la présente invention, en préparant un cosmétique pour les cheveux contenant un ou plusieurs ingrédients actifs de croissance des cheveux choisis parmi (A) un activateur cellulaire, (B) un agent d'amélioration de la circulation sanguine, (C) un agent anti-inflammatoire, (D) un bactéricide et (E) un stimulant local, le menthol, et un tensioactif non-ionique à base d'acide aminé en une quantité de 0,01 % en masse ou plus et moins de 3 % en masse, un cosmétique pour le cuir chevelu et les cheveux qui a une absorption transdermique améliorée d'ingrédient(s) actif(s) de croissance des cheveux par application externe de celui-ci sur le cuir chevelu et les cheveux, a un effet favorisant la croissance des cheveux et un effet de prévention de la chute des cheveux en particulier par application sur le cuir chevelu, et a en outre une excellente sensation d'utilisation lorsqu'il est utilisé.
PCT/JP2006/323755 2005-12-26 2006-11-29 Cosmetique pour le cuir chevelu et les cheveux WO2007074602A1 (fr)

Priority Applications (1)

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JP2005371888 2005-12-26

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WO2009150902A1 (fr) * 2008-06-09 2009-12-17 大塚製薬株式会社 Composition pour utilisation externe
JP2011148773A (ja) * 2009-12-21 2011-08-04 Lion Corp 頭皮頭髪化粧料
JP2011153122A (ja) * 2009-12-28 2011-08-11 Lion Corp 化粧料組成物
CN102475633A (zh) * 2010-11-22 2012-05-30 陈翰民 毛发生长促进剂
WO2012068714A1 (fr) * 2010-11-22 2012-05-31 Chen Han-Min Activateur de pousse des cheveux
JP2012184220A (ja) * 2011-02-17 2012-09-27 Lion Corp 頭皮頭髪化粧料
JP2013510174A (ja) * 2009-11-09 2013-03-21 アラーガン インコーポレイテッド 発毛を刺激する組成物および方法
WO2014006983A1 (fr) * 2012-07-05 2014-01-09 ライオン株式会社 Composition d'agent de pousse des cheveux
WO2014065274A1 (fr) * 2012-10-23 2014-05-01 野口 秀人 Solution à permanente, et conditionneur pour cheveux
JP2014084293A (ja) * 2012-10-23 2014-05-12 Sogo Akita パーマ液および頭髪用調整剤
JP2014177438A (ja) * 2013-03-15 2014-09-25 Sogo Akita パーマ液および頭髪用調整剤
JP2015078134A (ja) * 2013-10-15 2015-04-23 株式会社プロテックス・ジャパン 頭皮および頭髪用化粧料組成物
JP2015134736A (ja) * 2014-01-17 2015-07-27 ニベア花王株式会社 グリチルレチン酸の毛穴浸透促進剤、抗菌組成物、防臭用組成物、及び制汗防臭用組成物
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
JP2016069334A (ja) * 2014-09-30 2016-05-09 株式会社ダリヤ 育毛化粧料
JP2016132635A (ja) * 2015-01-19 2016-07-25 サンスター株式会社 化粧料組成物
WO2018158990A1 (fr) * 2017-03-02 2018-09-07 株式会社マンダム Produit de soin du cuir chevelu
JP7039086B1 (ja) * 2021-09-01 2022-03-22 新日本製薬株式会社 化粧料組成物、ホワイトニングジェル化粧料、目元用クリーム化粧料及びファンデーション用クリーム化粧料

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