WO2014006983A1

WO2014006983A1 - Hair growing agent composition

Info

Publication number: WO2014006983A1
Application number: PCT/JP2013/063559
Authority: WO
Inventors: 利江廣畠; 青野　恵; 俊輔廣島; 恭史柿澤
Original assignee: ライオン株式会社
Priority date: 2012-07-05
Filing date: 2013-05-15
Publication date: 2014-01-09
Also published as: KR101891509B1; KR20150035481A; JP6179513B2; JPWO2014006983A1; CN104470492A

Abstract

Provided is a hair growing agent composition comprising: (A) a hair growing active ingredient selected from 6- benzylaminopurine, pentadecanoic acid glyceride, minoxidil, carpronium chloride, t-flavanone and St. John's wort extract; (B) a salicylic acid derivative selected from glycol salicylate, methyl salicylate, dipropylene glycol salicylate, octyl salicylate, phenyl salicylate and homomenthyl salicylate; (C) an algefacient selected from l-menthol, menthyl glyceryl ether and peppermint oil; (D) ethanol; and purified water, wherein the mass ratio of the content represented by (B)/(C) is 1 to 50. This hair growing agent composition is capable of imparting sufficient warm sensation to the scalp even with one application thereby improving blood flow, and exhibits excellent hair growing effects (prevents hair loss and promotes hair growth) by the active ingredient when used for a prolonged period of time.

Description

Hair restorer composition

The present invention relates to a hair restorer composition capable of feeling both refreshing feeling and warm feeling.

The hair-growth effect is usually obtained by continuous use of a hair-growth nourishing agent over a long period of time, but none of the conventional hair-growth agents can achieve an effect when used once, leading to long-term use. There was no problem.

On the other hand, even if the hair restoring agent is used for a long period of time, the level of hair restoring effect required by consumers has not been sufficiently achieved.
In addition, the following are mentioned as prior art documents relevant to the present invention.

JP 2001-354579 A

The present invention has been made in view of the above circumstances, and even when applied once, the scalp can be provided with a sufficient feeling of refreshment and warmth, can improve blood flow, and can be used over a long period of time. An object of the present invention is to provide a hair restorer composition excellent in hair growth effect (prevention of hair loss, promotion of hair growth) due to an active ingredient at the time.

As a result of intensive studies to achieve the above object, the inventors of the present invention have (B) a specific salicylic acid in (B) a specific hair-recovery composition containing (A) a hair-growth active ingredient, (D) ethanol, and (E) purified water. Surprisingly, as shown in FIG. 1 to be described later, when a derivative is combined with (C) a specific refreshing agent and blended at a specific ratio, a refreshing feeling is felt immediately after application to the scalp. After that, since the refreshing feeling weakens and the warming feeling becomes stronger immediately after that, it is found that the balance between the refreshing feeling and the warm feeling can give the user a high satisfaction that has never been seen before, It has been found that the blood flow in the scalp can be sufficiently increased because the warm feeling continues. In addition, the warm feeling obtained in this way is felt in a small amount compared to extracts such as chili pepper tincture that have been used as a conventional warming ingredient, and is not accompanied by irritation such as chili pepper tincture. It was found to be a feeling and the present invention was made.

Accordingly, the present invention provides the following hair restorer composition.
[1]
(A) 6-benzylaminopurine, pentadecanoic acid glyceride, minoxidil, capronium chloride, t-flavanone and hypericum extract, (B) glycolic salicylate, methyl salicylate, dipropylene glycol salicylate, octyl salicylate, salicylic acid A salicylic acid derivative selected from phenyl and homomenthyl salicylate;
(C) a refreshing agent selected from 1-menthol, menthyl glyceryl ether and mint oil;
(D) ethanol,
(E) A hair restorer composition containing purified water and having a mass ratio of 0.5 to 50 represented by (B) / (C).
[2]
(B) The hair restorer composition according to [1], wherein the component is selected from glycol salicylate, methyl salicylate, and dipropylene glycol salicylate.
[3]
The hair restorer composition according to [1] or [2], wherein the blending amount of component (B) is 0.01 to 5% by mass and the blending amount of component (C) is 0.01 to 5% by mass.
[4]
The hair restorer composition according to any one of [1] to [3], wherein the amount of component (D) is 55% by mass or more and the amount of component (E) is 12 to 43% by mass.
[5]
The hair restoring composition according to any one of [1] to [4], further comprising (F) a component selected from pepper tincture, ginger extract and loquat leaf extract.
[6]
The hair-restoring agent composition according to any one of [1] to [5], further comprising (G) a transdermal absorption enhancer.

The hair restorer composition of the present invention has a strong refreshing feeling immediately after application to the scalp, and immediately after that, the refreshing feeling weakens and the warmth becomes stronger. High satisfaction can be given to the person. Moreover, since this warm feeling continues, the blood flow volume of a scalp can fully be raised. Moreover, the warm sensation by the composition of the present invention is an unprecedented warm sensation that does not involve irritation such as chili pepper tincture, and can be used over a long period of time to prevent hair loss and promote hair growth.

It is a graph which shows how to feel refreshing feeling and warm feeling.

The composition of the present invention comprises:
(A) hair-growth active ingredient,
(B) a salicylic acid derivative,
(C) freshener,
(D) ethanol,
(E) A refreshing / warm hair-growing composition containing purified water.
In the present invention, the refreshing / warm hair-growing composition refers to a hair-growing composition that can first feel a refreshing feeling and then a warm feeling after being applied to the scalp. Specifically, it is 0 to 5 minutes after application, especially 0 minutes to less than 3 minutes after starting application, and it is 3 to 7 minutes after application, particularly 3 to 5 minutes after application. Preferably there is.

[(A) Hair-growth active ingredient]
The component (A) used in the present invention is a known hair-growth active ingredient having a hair-growth effect (prevention of hair loss, hair growth promotion). For example, 6-benzylaminopurine, pentadecanoic acid glyceride, minoxidil, capronium chloride, t -Flavanone, hypericum extract and the like. These can be used alone or in appropriate combination of two or more. From the viewpoint of hair growth effect, 6-benzylaminopurine, pentadecanoic acid glyceride and minoxidil are preferable, and from the viewpoint of hair loss improvement and hair growth promoting effect. More preferred are 6-benzylaminopurine and pentadecanoic acid glycerides.

The blending amount of the component (A) is preferably 0.1 to 5% by mass, more preferably 0.5 to 3% by mass with respect to the total amount of the composition from the viewpoint of hair loss improvement and hair growth promoting effect. By setting it as the said range, hair loss improvement and the hair growth promotion effect increase more, and it can suppress that the background becomes sticky at the time of application | coating.

[(B) Salicylic acid derivative]
(B) By combining a salicylic acid derivative with a refreshing agent of the following component (C) at a predetermined ratio, surprisingly, the scalp first has a refreshing sensation, then a refreshing sensation and a warm sensation. It can be given in a smaller amount than conventional warming ingredients such as chili pepper tincture, and without causing irritation, a high warming effect can be obtained, and the warming imparting effect on the scalp and the blood flow improvement effect are dramatically improved improves. Examples of the component (B) include salicylic acid derivatives such as glycol salicylate, methyl salicylate, dipropylene glycol salicylate, octyl salicylate, phenyl salicylate, and homomenthyl salicylate. These can be used singly or in appropriate combination of two or more, but salicylate glycol, methyl salicylate and dipropylene glycol salicylate are preferred, more preferably from the viewpoint of imparting warmth and improving blood flow. Salicylic acid glycol.

The blending amount of the component (B) is preferably 0.01 to 5% by mass, more preferably 0.3 to 2% by mass with respect to the total amount of the composition from the viewpoint of imparting warmth and improving blood flow. . If it is less than 0.01% by mass, the imparting of warmth and the effect of improving blood flow may be inferior, and if it exceeds 5% by mass, the background may be sticky, the improvement of blood flow and the effect of imparting warmth may be inferior.

[(C) Coolant]
By blending the component (C) together with the component (B), as described above, a refreshing feeling and a warm feeling can be imparted to the scalp, and the effect of improving the blood flow can be remarkably enhanced. Examples of the component (C) include l-menthol, menthyl glyceryl ether, mint oil and the like. These can be used singly or in appropriate combination of two or more, but l-menthol is preferable from the viewpoint of imparting warmth and improving blood flow.

The blending amount of the component (C) is preferably 0.01 to 5% by mass and more preferably 0.1 to 2% by mass with respect to the total amount of the composition from the viewpoint of imparting warmth and improving blood flow. If it is less than 0.01% by mass, the effect of imparting warmth and the effect of improving blood flow may be inferior, and if it exceeds 5% by mass, the effect of imparting warmth may be inferior.

Here, the blending ratio of the component (B) and the component (C) is (B) / (C), and the content ratio of the component (B) to the component (C) is improved in warmth and blood flow. From the viewpoint, it is 0.5 to 50, preferably 1 to 50, more preferably 1.5 to 20, and further preferably 2.5 to 10. When this mass ratio is less than 0.5, the blood flow and warming effect are inferior, and when it exceeds 50, the warming and blood flow improving effect is poor.

[(D) ethanol]
(D) Examples of ethanol include absolute ethanol and 95% by volume ethanol. From the viewpoint of imparting warmth to the scalp and improving blood flow, 55% by mass or more is preferable as absolute ethanol with respect to the total amount of the composition, and more preferably 60% by mass or more. The upper limit is not particularly limited, but may be 85% by mass or less, particularly 80% by mass or less from the viewpoint of not stimulating a person with sensitive skin. In addition, this compounding quantity is a compounding quantity containing the ethanol brought in from these extracts, when extracts, such as a plant extract, are mix | blended.

[(E) Purified water]
(E) Purified water is preferably 12 to 43% by mass, more preferably 18 to 37% by mass, based on the total amount of the composition, from the viewpoint of imparting warmth and improving blood flow. By setting it within the above range, a warmer feeling can be felt and the blood flow can be further improved. In addition, this compounding quantity is a compounding quantity containing the purified water brought in from these extracts, when extracts, such as a plant extract, are mix | blended.

Here, the preferable blending ratio of the component (D) and the component (E) is the content of the component (D) with respect to the component (E) represented by (D) / (E) in terms of warmth and blood flow improvement. The mass ratio is preferably 1.3 to 4.4, more preferably 1.4 to 4. By setting it within the above range, the blood flow volume increases, the warmth is more easily felt, and the scalp can be prevented from sticking. In this case, the hair-restoring agent composition of the present invention is particularly suitable for men and women because it has a feeling of use, has no stickiness, and is excellent in preventing hair loss. It is effective for women, because it can soften hair and show a large amount.

[(F) Extracts]
In the present invention, in addition to the components (A) to (E), an extract (F) can be blended in order to further improve warmth, blood flow and hair growth effect. (F) As a component, a shrimp extract, a loquat leaf extract, a red pepper tincture, etc. can be used individually by 1 type or in combination of 2 or more types as appropriate. Among these extracts, a pepper extract and a loquat leaf extract are more preferable because of lack of warmth and irritation. Solvents used for extraction of these extracts are not particularly limited, but include polyhydric alcohols such as water, lower alcohols such as methanol, ethanol, propanol and isopropanol, 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin. Examples thereof include ethers such as alcohol, ethyl ether and propyl ether, esters such as ethyl acetate and butyl acetate, polar organic solvents such as acetone and methyl ethyl ketone, physiological saline, and phosphate buffer.

A commercial item can be used as each extract of such (F) component.
For example, Falco Rex Showa E (Showa Extract 1.30% by mass (pure extract), water 69.45% by mass, absolute ethanol 29.25% by mass) (Ichimaru Falcos Co., Ltd.), Ginger tincture (1.00% by mass of ginger root extract (pure extract), 25.74% by mass of water, 73.26% by mass of absolute ethanol) (manufactured by Maruzen Pharmaceutical Co., Ltd.) and the like.

The loquat leaf extract is, for example, loquat extract-J (loan leaf extract 1.4% by mass (pure extract), water 49.3% by mass, absolute ethanol 49.3% by mass), loquat leaf extract CA (loan leaf extract). 1% by weight of extract (pure extract), 99% by weight of 1,3-butylene glycol), loquat extract BG-J (1.5% by weight of loquat leaf extract (pure extract), 49.25% by weight of water, 1% , 3-butylene glycol 49.25% by mass), loquat extract LA (0.96% by mass of loquat leaf extract (pure extract), 69.33% by mass of water, 29.71% by mass of absolute ethanol) (all of which are Maruzen Manufactured by Pharmaceutical Co., Ltd.), Falcolex Biwaleaf B (1.5% by mass of Biwa leaf extract (extracted extract), 49.25% by mass of water, 49.25% by mass of 1,3-butylene glycol), Falcolex Biwaleaf E (Biwa Extract 1.58 wt% (extract pure content), water 66.65 wt%, ethanol 31.77 mass%) (both Ichimaru Pharcos Co., Ltd.).

Examples of the pepper tincture include chili pepper tincture (capsicum fruit extract 0.30% by mass (extracted pure), 99.7% by mass absolute ethanol) (manufactured by Maruzen Pharmaceutical Co., Ltd.).

When the component (F) is blended, with respect to the ginger leaf extract and loquat leaf extract, the blending amount is 0. 0 as the pure extract with respect to the total amount of the composition in terms of hair loss improvement, warmth and blood flow improvement. 0001 mass% or more is preferable, More preferably, it is 0.003 mass% or more. By setting it as 0.0001 mass% or more, a blood flow rate and a warm feeling can be improved more. The upper limit is not particularly limited, but is preferably 0.07% by mass or less, more preferably 0.05% by mass or less, and particularly preferably 0.02% by mass or less as a pure extract from the point of not causing irritation.
Moreover, about chili pepper tincture, 0.00003 mass% or more is preferable as an extract pure part, More preferably, it is 0.0009 mass% or more. A feeling of warmth can be improved more by setting it as 0.00003 mass% or more. The upper limit is not particularly limited, but is preferably 0.015% by mass or less, particularly preferably 0.003% by mass or less from the viewpoint of not causing irritation.

[(G) Transdermal absorption enhancer]
The percutaneous absorption enhancer is a component that promotes absorption of (A) a hair-growth active ingredient from the skin, and also has an action of promoting blood flow, specifically, polyethylene glycol having an average molecular weight of 190 to 210. 200, polyethylene glycol 300 having an average molecular weight of 280 to 320, polyethylene glycol 400 having an average molecular weight of 380 to 420, polyethylene glycol 600 having an average molecular weight of 570 to 630, diisopropyl adipate, lecithin, myristyl lactate, lauryl lactate, ethyl lactate and the like And mono-, di- or triglycerides of medium chain fatty acids such as monocaprylic acid. Among these, polyethylene glycol 300 having an average molecular weight of 280 to 320 and polyethylene glycol 400 having an average molecular weight of 380 to 420 are preferable from the viewpoint of hair loss improvement and blood flow. In the present invention, the average molecular weight is measured by applying the test method (p1378) of polyethylene glycol 200 listed in the quasi-drug raw material standard 2006 (Pharmaceutical Daily).

(G) When mix | blending a component, the compounding quantity is 0.01 mass% or more from the point of hair loss improvement, the hair growth effect, and blood flow improvement with respect to the composition whole quantity, More preferably, it is 0.3 mass% or more. It is. By setting it as the said range, a blood flow rate can be improved more and the percutaneous absorption promotion effect can be heightened more. The upper limit is not particularly limited, but is preferably 5% by mass or less, and particularly preferably 3% by mass or less from the viewpoint that stickiness does not occur in terms of use.

[Other ingredients]
In the hair restorer composition of the present invention, an optional component other than the above-mentioned components that are usually blended in the hair restorer composition is used alone or in combination of two or more, as long as the effects of the present invention are not impaired. Can do. Examples of such components include nonionic surfactants, semipolar surfactants, amphoteric surfactants, anionic polymers, nonionic polymers, polyols other than the component (G), organic salts, humectants, tonic agents, Solubilizers, antioxidants such as dibutylhydroxytoluene and α-tocopherol, bactericides such as triclosan and trichlorocarban, viscosity modifiers such as fatty acid monoethanolamide and fatty acid diethanolamide, UV absorbers, antioxidants, protein derivatives Animal and plant extracts, anti-dandruff agents such as piroctone olamine and zinc pyrithione, anti-inflammatory agents such as dipotassium glycyrrhizinate, benzoic acid and salts thereof, parabens, preservatives such as caisson CG, citric acid, triethanolamine and the like pH adjusters, pearlizing agents such as ethylene glycol difatty acid esters, milk Agents, hydrotropes, vitamins, volatile oil, hydrophobic solvents, dilution solvents can optionally be added (F) extracts, other than the component, dyes, perfumes.

[Usage]
The hair restorer composition (cool feeling (cool feeling) / warm hair restorer composition) of the present invention can be widely used as a hair restorer, a hair nourishing agent, a blood circulation promoter, and a hair loss improving agent, and is particularly preferably used as a hair restorer. . In this case, it can be used for external use in the form of a hair-growth tonic, scalp essence, hair-growth spray, hair-growth hair gel or the like. The hair restorer composition of the present invention can be obtained based on a conventional method by mixing the above essential components and optional components.

[Container, container material]
Examples of the container for filling the hair-restoring agent composition of the present invention include aluminum laminate tubes, EVAL tubes, aluminum tubes, glass-deposited plastic tubes, and the like, as well as dispenser containers and squeeze containers by mechanical or differential pressure, laminate film containers, A dropper container, a stick container, a bottle container, etc. are mentioned. The laminated film of aluminum laminated tube usually has two or more layers, and the material is synthetic resin such as polyethylene, polyethylene terephthalate, polyester, biaxially stretched polypropylene, unstretched polypropylene, polyacrylonitrile, ethylene vinyl acetate copolymer, etc. It is preferably made of paper, aluminum-deposited plastic, or the like. In consideration of strength, flexibility, weather resistance, etc., it is generally preferable to use one having 2 to 5 layers. As the bottle material, polyethylene, polypropylene, polyethylene terephthalate, polystyrene, polyvinyl chloride, ethylene-vinyl alcohol resin, acrylonitrile / styrene resin, ABS resin, polyamide, glass, etc. can be used in a single layer or in combination of two or more layers. .

Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

[Examples 1 to 56, Comparative Examples 1 to 5]
A hair restorer composition having the composition shown in the following table was prepared according to a conventional method and evaluated by the following method. The results are also shown in the table. In addition, in the following table | surface, the numerical value in () of polyoxyethylene tetraoleate (40) sorbit shows the average addition mole number of ethylene oxide. The blending amount of (D) ethanol and (E) purified water indicates the total amount contained in the composition. In addition, (D) ethanol is the quantity as absolute ethanol. Components (A) to (C) are pure equivalents. In the case of extracts, the upper part is solid, and the lower part indicates the amount of pure extract. Each composition of an Example and a comparative example was mix | blended so that the whole quantity might be 100 mass%.
All of the hair restorer compositions of the obtained examples were not sticky to the background.

[Improve hair loss]
<Evaluation method>
For 40 women in their 50s and 60s, use about 1.5mL of hair restorer composition at a time, twice a day (twice at intervals, for a total of 2 times) for 1 month. It was evaluated whether or not the number of hair loss after use decreased compared to before use.
<Evaluation criteria>
5 points: 36 or more out of 40 responded that hair loss was reduced. 4 points: 28 to 35 out of 40 responded that hair loss was reduced. 3 points: 20 to 27 or less out of 40 persons. 2 points: 12 to 19 out of 40 people answered that hair loss was reduced 1 point: 11 or less of 40 people answered that hair loss was reduced

[Hair growth effect]
<Evaluation method>
For 40 women in their 50s and 60s, use about 1.5mL of hair restorer composition at a time, twice a day (twice at intervals, for a total of 2 times) for 1 month. It was evaluated whether the hair after use increased compared to before use.
<Standard>
5 points: 36 or more out of 40 responded that their hair increased 4 points: 28 to 35 out of 40 responded that their hair increased 3 points: 20 or more out of 40 and 27 or less 2 points: 12 to 19 out of 40 people answered that hair increased 1 point: 11 or less of 40 people answered that hair increased

[Blood flow]
<Evaluation method>
For 5 female subjects in their 40s to 50s, 67 μL of sample was applied to a specific area 2 cm square on the forearm, and 3 minutes later, blood flow T1 was measured using a laser blood flow meter OMEGAFLO (Omega Wave). did. Compared with the blood flow volume (T0) before applying the sample (blank), the blood flow volume increase rate was calculated by the following formula, and the average value of 5 persons was obtained.
Increasing rate of blood flow = {(T1-T0) / T0} × 100 (%)
<Evaluation criteria>
◎: Blood flow increased by 30% or more and 50% or less than blank ◎ ~ ○: Blood flow increased by 20% or more but less than 30% than blank ○: Blood flow increased by 15% or more but less than 20% than blank △: Blank Blood flow increased more than 10% but less than 15% more than ×: Blood flow increased less than 10% or no change from blank

[Warm feeling]
<Evaluation method>
Ten women in their 40s to 60s applied about 1.5 mL of the sample to the scalp in a towel-dried state after washing the hair, and evaluated the presence or absence of warm feeling 5 minutes after application. Evaluation was performed according to the following evaluation criteria, and an average value of 10 people was calculated.
<Evaluation criteria>
Very feel: 5 points Feel quite: 4 points Feel: 3 points Somewhat feel: 2 points Don't feel: 1 point
4.5 points or more and 5 points or less: ◎
4 or more and less than 4.5: ◎ to ○
3 points or more and less than 4 points: ○
2 points or more and less than 3 points: △
1 point or more and less than 2 points: ×

[Sensation of coolness]
<Evaluation method>
Ten women in their 40s to 60s applied about 1.5 mL of the sample to the scalp in a towel-dried state after shampooing, and evaluated whether there was a refreshing feeling within 5 minutes immediately after application. Evaluation was performed according to the following evaluation criteria, and an average value of 10 people was calculated.
<Evaluation criteria>
Very feel: 5 points Feel quite: 4 points Feel: 3 points Somewhat feel: 2 points Don't feel: 1 point
4.5 points or more and 5 points or less: ◎
4 or more and less than 4.5: ◎ to ○
3 points or more and less than 4 points: ○
2 points or more and less than 3 points: △
1 point or more and less than 2 points: ×

FIG. 1 shows a graph showing an example of how to feel cool and warm about one subject. A broken line indicates a refreshing feeling and a solid line indicates a warm feeling.

[No sense of irritation]
<Evaluation method>
Ten women in their 40s to 60s applied approximately 1.5 mL of the sample to the scalp in a towel-dried state after washing the hair, and evaluated the presence or absence of irritation after application. Evaluation was performed according to the following evaluation criteria, and an average value of 10 people was calculated.
<Evaluation criteria>
I do not feel at all: 5 points I do not feel: 4 points I do not feel a little: 3 points I feel: 2 points I feel very much: 1 point
4.5 points or more and 5 points or less: ◎
4 or more and less than 4.5: ◎ to ○
3 points or more and less than 4 points: ○
2 points or more and less than 3 points: △
1 point or more and less than 2 points: ×

The raw materials used in Examples and Comparative Examples are shown below.

Claims

(A) a hair-growth active ingredient selected from 6-benzylaminopurine, pentadecanoic acid glyceride, minoxidil, capronium chloride, t-flavanone and hypericum extract;
(B) a salicylic acid derivative selected from glycol salicylate, methyl salicylate, dipropylene glycol salicylate, octyl salicylate, phenyl salicylate and homomenthyl salicylate;
(C) a refreshing agent selected from 1-menthol, menthyl glyceryl ether and mint oil;
(D) ethanol,
(E) A hair restorer composition containing purified water and having a mass ratio of 0.5 to 50 represented by (B) / (C).
The hair restorer composition according to claim 1, wherein the component (B) is selected from glycol salicylate, methyl salicylate and dipropylene glycol salicylate.
3. The hair restorer composition according to claim 1 or 2, wherein the amount of component (B) is 0.01 to 5% by mass and the amount of component (C) is 0.01 to 5% by mass.
The hair restorer composition according to any one of claims 1 to 3, wherein the blending amount of the component (D) is 55% by mass or more and the blending amount of the component (E) is 12 to 43% by mass.
The hair-restoring agent composition according to any one of claims 1 to 4, further comprising (F) a component selected from chili pepper tincture, ginger extract and loquat leaf extract.
The hair restorer composition according to any one of claims 1 to 5, further comprising (G) a transdermal absorption enhancer.