KR102132713B1 - Composition for improving hair and scalp condition - Google Patents

Abstract

The present invention relates to a composition for hair tonic that can provide a refreshing feeling and prevent hair loss by smoothing nutrient supply by activating long cooling duration and blood circulation of hair roots.

Description

Composition for improving hair or scalp condition {Composition for improving hair and scalp condition}

The present specification relates to a composition for improving hair or scalp condition, more specifically a composition for hair tonic, which can provide a refreshing feeling and prevent hair loss by providing long cooling duration and activating blood circulation of hair roots to facilitate nutrient supply.

Alopecia patients are also rapidly increasing due to the increase in the elderly population. Alopecia does not have a direct effect on life, but there are many problems in terms of beauty such as making it look older. Accordingly, various methods have been used, such as hair transplantation, transdermal and oral administration of hair loss inhibitors, and wearing wigs.

Wearing a wig is most desirable from a health standpoint, as it does not require medication or surgery. However, the air circulation is not smooth when wearing a wig, and it is very uncomfortable because it feels frustrating and hot. In particular, people with severe hair loss should wear it in the summer, but when the weather is hot, discomfort is exacerbated.

In the case of sports or soldiers wearing hats such as golf or baseball, the air circulation to the head is not smooth, like a wig, and it is very uncomfortable because it gives a frustrating and hot feeling. In addition, farmers and workers who need to work outdoors in hot weather are exposed to heat, which adversely affects their health, as well as death due to heat sickness. As such, the environment in everyday life, which is not very important, can cause serious problems that take people's lives.

Meanwhile, when water or alcohol comes into contact with our skin, it feels cool. This is due to the heat of vaporization of the material. In other words, in the liquid or solid state, molecules are bound to each other by van der waals force, hydrogen bond, etc., and in order to turn into a gas, they break these bonds and move away by a distance of 1000 times or more. At this time, energy required is absorbed from the surroundings, and this is called heat of vaporization or heat of evaporation. The heat of vaporization of water is 40.65 kJ/mol, and the heat of vaporization of ethanol is 38.6 kJ/mol. The reason why you feel refreshed when water or alcohol comes into contact with your skin is caused by this heat of vaporization. Because water or ethanol has a fast vaporization due to low heat of vaporization, the cooling effect does not last long, and most materials have a high heat of vaporization, so it is difficult to vaporize near room temperature and thus cannot exhibit a cooling effect.

On the other hand, menthol stimulates the cold and menthol receptor 1 (CMR1) called Transient receptor potential cation channel subfamily M member 8 (TRPM8) in our skin, not because of the heat of vaporization, so that it feels refreshing (ACS Chemical Neuroscience, 3, 248-267, 2012).

In Korean Patent 10-2015-0035481, a hair growth agent composition was developed using menthol and its derivatives, salicylic acid and its derivatives to feel warm after cooling. In the preceding literature, the initial (about 0-5 minutes) was expressed as a refreshing feeling, and since then, a warm feeling due to salicylic acid was exhibited.

As in the above document, in general, menthol has an advantage of being inexpensive and showing a certain cooling effect, but has a disadvantage that it cannot exhibit a sufficient cooling duration due to strong volatility. According to WO 2006/103401 A2, as a result of examining the cooling duration of an ointment containing 1% cooling agent, WS-3, a type of menthol and a cooling agent, is about 20 minutes and WS-5 is about 35 minutes, resulting in a very short cooling duration. Was reported.

Therefore, there is an urgent need for a new hair tonic product that can maintain a constant refreshing feeling in the hair tonic product.

Korean Patent Publication No. 10-2015-0035481 International Patent Publication WO 2006/103401 A2

Accordingly, the present inventors wear wigs, wear hats, outdoor exercise, and work to alleviate the body's body temperature and tightness, provide blood circulation to the scalp, provide a feeling of refreshment, and prevent heat disease. It is intended to provide a tonic composition.

The object of the present invention is not limited to the object mentioned above. The object of the present invention will be more apparent from the following description, and will be realized by means described in the claims and combinations thereof.

One aspect of the present invention, menthol (menthol), icilin (icilin), menthol derivatives and carboxamide (carboxamide)-based refreshing agent comprising any one or more of the refreshing agent; And cyclodextrin (cyclodextrin, CD); includes, the refresher provides a composition for improving the condition of the hair or scalp, in the form of inclusion in the ring of the cyclodextrin.

In one aspect of the present invention, the menthol derivative is any one or more of Frescolat MGA, Frescolat ML, Coolact 5 and Coolact P, and the carboxamide-based refreshing agent is WS-3, WS-23, WS-14, and Provided is a composition for improving hair or scalp condition, any one or more of WS-5.

In one aspect of the present invention, the refreshing agent is 0.01% by weight to 3% by weight relative to the total weight of the composition, and the cyclodextrin is 0.01% by weight to 3% by weight based on the total weight of the composition. to provide.

In one aspect of the present invention, the equivalent ratio of the cyclodextrin to the refreshing agent (equivalent ratio of CD/cooling agent) is an equivalent ratio of 0.01 to 4, and provides a composition for improving hair or scalp condition.

In one aspect of the present invention, the composition provides a composition for improving hair or scalp condition, further comprising at least one hair growth active ingredient selected from minoxidil, Carpronium chloride (CPC), Benzylaminopurine (BAP) and flavanone.

In one aspect of the invention, the composition comprises a freshener/CD inclusion body; oil; Emulsifiers; Moisturizing agent: Provides a composition for improving hair or scalp condition, comprising a hair growth active ingredient and a solvent.

In one aspect of the invention, the oil is olive oil, avocado oil, almond oil, malt oil, apricot seed oil, walnut colostrum oil, rose hip oil, macadamia oil, cacao oil, peppermint oil, perm oil, camellia oil, cottonseed oil, safflower seed oil and One or more selected from grapeseed oil, and the emulsifier is olive wax, emulsifying wax, candelilla wax, stearic acid, lecithin, cetos, and monta wax ), and the humectant is at least one selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol (PEG), and the solvent is water, a lower alcohol of C1-5, and a mixture of alcohol and water of C1-5 Provided is a composition for improving hair or scalp condition, which is one of the solvents.

In one aspect of the present invention, the composition further comprises any one or more of isoflavones, soybean extract, rat bean extract, ginseng extract, aronia extract, ginger extract and other ingredients of pipa extract, for improving hair or scalp condition Provided is a composition.

In one aspect of the present invention, the composition provides a composition that is a formulation selected from the group consisting of hair tonic, hair nutrient longevity, scalp treatment, hair treatment, hair rinse, hair shampoo and hair lotion.

In the present invention, in the case of wearing a wig, wearing a hat, outdoor work, etc., it is intended to provide a hair tonic composition capable of alleviating the tightness of the head, promoting blood circulation and refreshing feeling of the scalp, and preventing thermal diseases.

The effects of the present invention are not limited to the effects mentioned above. It should be understood that the effects of the present invention include all effects that can be deduced from the following description.

1 is the chemical structure of CD.
2 is the inclusion body structure of menthol-CD
3 is a schematic of the size of a menthol-CD inclusion.
4 is an illustration of various refreshing agents having a structure similar to menthol and their chemical structural formulas.

Unless otherwise specified, all numbers, values, and/or representations of ingredients, reaction conditions, and content of ingredients used herein are various of the measurements that occur in obtaining these values, among other things, those numbers are essentially different. As these are approximations that reflect uncertainty, it should be understood that in all cases they are modified by the term "about". In addition, when numerical ranges are disclosed in this description, these ranges are continuous, and include all values from the minimum value in this range to the maximum value including the maximum value, unless otherwise indicated. Further, when such a range refers to an integer, all integers including the minimum value to the maximum value including the maximum value are included unless otherwise indicated.

In the present specification, when a range is described for a variable, it will be understood that the variable includes all values within the stated range including the described endpoints of the range. For example, a range of “5 to 10” includes values of 5, 6, 7, 8, 9, and 10, as well as any subrange of 6 to 10, 7 to 10, 6 to 9, 7 to 9, and the like. It will be understood to include, and include any value between integers pertinent to the stated range of ranges such as 5.5, 6.5, 7.5, 5.5 to 8.5 and 6.5 to 9, and the like. Also, for example, the range of “10% to 30%” is 10% to 15%, 12% to 10%, 11%, 12%, 13%, etc. and all integers including up to 30% It will be understood that it includes any subranges such as 18%, 20% to 30%, etc., and includes any value between valid integers within the scope of the stated range, such as 10.5%, 15.5%, 25.5%, and the like.

Hereinafter, the present invention will be described in detail.

In the composition for hair tonic, as described above, menthol is inexpensive and has a certain cooling effect, but has a disadvantage that it cannot exhibit a sufficient cooling duration due to strong volatility.

Accordingly, in the present invention, an inclusion complex phenomenon between cyclodextrin (CD) and menthol was used to increase the cooling duration. CD is an annular structure composed of glucose as shown in FIG. 1. Specifically, when this material encounters a hydrophobic material such as menthol in water, hydrophobic hydrocarbons are arranged on the inside of the ring structure and hydrophilic hydroxyl groups on the outside of the ring structure as shown in FIG. 2. Accordingly, the hydrophobic menthol is present in the ring of the CD and the size of the ring is calculated as shown in FIG. 3.

Menthol is inherently hydrophobic, and is poorly soluble in water. However, the inclusion of water increases the solubility in water. Therefore, the production of hair tonic becomes very smooth with or without a small amount of alcohol. Alcohol has the disadvantage of drying the skin and the risk of explosion or fire in use. In addition, when inclusion, van der daals and hydrophobic bonds occur between CD and menthol, and the heat of vaporization required to evaporate is increased, so more energy is required to vaporize menthol, thus lowering volatility and increasing the cooling duration. .

Various refreshing agents having a structure similar to menthol can be used in the present invention. These are menthol derivatives such as menthol derivatives, icilin, carboxamide refreshers, etc., by a mechanism similar to menthol. Menthol derivatives include Frescolat MGA, Frescolat ML, Coolact 5, Coolact P, etc., and carboxamide softeners include WS-3, WS-23, WS-14, and WS-5. This is as shown in FIG. 4.

Cooling agents such as the above have the disadvantage that the cooling duration is not long, similar to menthol. However, as shown in FIG. 4, since it is a hydrophobic material, it can be encapsulated with CD. Therefore, in the present invention, in order to prolong their cooling duration, they were used by inclusion with CD.

Hereinafter, various aspects of the present invention will be described.

One aspect of the present invention, menthol (menthol), icilin (icilin), menthol derivatives and carboxamide (carboxamide)-based refreshing agent comprising any one or more of the refreshing agent; And cyclodextrin (cyclodextrin, CD); includes, the refresher provides a composition for improving the condition of the hair or scalp, in the form of inclusion in the ring of the cyclodextrin.

In one aspect of the present invention, the menthol derivative is any one or more of Frescolat MGA, Frescolat ML, Coolact 5 and Coolact P, and the carboxamide-based refreshing agent is WS-3, WS-23, WS-14, and Provided is a composition for improving hair or scalp condition, any one or more of WS-5.

In one aspect of the present invention, the refreshing agent is 0.01% by weight to 3% by weight relative to the total weight of the composition, and the cyclodextrin is 0.01% by weight to 3% by weight based on the total weight of the composition. to provide.

In one aspect of the present invention, the equivalent ratio of the cyclodextrin to the refreshing agent (equivalent ratio of CD/cooling agent) is an equivalent ratio of 0.01 to 4, and provides a composition for improving hair or scalp condition.

In one aspect of the present invention, the composition provides a composition for improving hair or scalp condition, further comprising at least one hair growth active ingredient selected from minoxidil, Carpronium chloride (CPC), Benzylaminopurine (BAP) and flavanone.

In one aspect of the invention, the composition comprises a freshener/CD inclusion body; oil; Emulsifiers; Moisturizing agent: Provides a composition for improving hair or scalp condition, comprising a hair growth active ingredient and a solvent.

In one aspect of the invention, the oil is olive oil, avocado oil, almond oil, malt oil, apricot seed oil, walnut colostrum oil, rose hip oil, macadamia oil, cacao oil, peppermint oil, perm oil, camellia oil, cottonseed oil, safflower seed oil and One or more selected from grapeseed oil, and the emulsifier is olive wax, emulsifying wax, candelilla wax, stearic acid, lecithin, cetos, and monta wax ), and the humectant is at least one selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol (PEG), and the solvent is water, a lower alcohol of C1-5, and a mixture of alcohol and water of C1-5 Provided is a composition for improving hair or scalp condition, which is one of the solvents.

In one aspect of the present invention, the composition further comprises any one or more of isoflavones, soybean extract, rat bean extract, ginseng extract, aronia extract, ginger extract and other ingredients of pipa extract, for improving hair or scalp condition Provided is a composition.

In one aspect of the present invention, the composition provides a composition that is a formulation selected from the group consisting of hair tonic, hair nutrient longevity, scalp treatment, hair treatment, hair rinse, hair shampoo and hair lotion. In addition, other ingredients in addition to the above-described essential ingredients in each formulation may be appropriately selected and blended without difficulty by those skilled in the art according to the type or purpose of use of other external agents. The composition according to the present specification can be provided in any formulation suitable for topical application. For example, a solution, an emulsion obtained by dispersing an oil phase in an aqueous phase, an emulsion obtained by dispersing an oil phase in an oil phase, suspension, solid, gel, powder, paste, micro needle, foam or aerosol composition may be provided in the form of a composition. have. Compositions of these formulations can be prepared according to conventional methods in the art.

Hereinafter, an embodiment of the present invention will be described.

The composition of the present invention comprises (A) a coolant/CD inclusion body; (B) oil; (C) emulsifiers; (D) Moisturizing agent: (E) Hair growth active ingredient: (F) Solvent; (G) A long-lasting hair tonic composition containing other ingredients.

(A) Softener/CD inclusion body

When menthol and CD are added to water and stirred, menthol melts and forms inclusion bodies bound to CD. Partially, it is present in a molten state, and most of it is dispersed as fine particles. The menthol and CD react at an equivalent ratio, and an equivalent ratio of CD/menthol is preferably 0.01 to 4. More preferably, 0.1-2 is suitable. When the equivalence ratio is 4 or more, the reaction amount of the inclusion body increases, but there may be many CDs, so the touch may not be good. Therefore, in order to increase the duration of cleanliness, the amount of CD should be relatively increased. If the amount of CD is decreased, the amount of non-encapsulated menthol increases, and the initial evaporation amount increases, so it is good to reduce the amount of CD to increase the refreshing feeling in the initial stage of use.

When making inclusion bodies, there are co-precipitation method, slurry method, paste method, etc.. Based on CD, it can be reacted by adding up to 40-45% of water. In general, the coolant/CD inclusion body is easier to disperse by making the inclusion body separately and using it in the formulation, rather than preparing it when mixing the hair tonic.

As a refreshing agent, not only menthol, but also icilin, Frescolat MGA, Frescolat ML, Coolact 5, Coolact P, WS-3, WS-23, WS-14, and WS-5 are hydrophobic compounds. You can make and use the prepared inclusion bodies. Similar to menthol, these compounds also bind CD in a mutual equivalence ratio. There are alpha type, beta type, gamma type, and the like in the CD. In the present invention, a beta type CD is generally suitable.

In the hair tonic composition prepared in this way, the component of the refreshing agent is suitably 0.01-3 wt%, more preferably 0.1-3 wt%. If it is less than 0.01 wt%, the cooling feeling may be low or the duration of cooling may be short, and when it exceeds 3 wt%, skin irritation and pain may occur.

In the hair tonic composition, CD is suitably 0.01-3 wt%, more preferably 0.05-1.5 wt%. When the content is less than 0.01 wt%, inclusion body formation may be small, and when it exceeds 3 wt%, the viscosity may be high and the touch may not be good.

The inclusion body increases the solubility in water rather than the cooling agent itself, but it is not very good. Therefore, when a nutrient containing inclusion bodies is used on the scalp, when there is no sweat, it is present in a solid state, so that the feeling of cooling is reduced, and when sweat or water is supplied by heat or exercise, the inclusion bodies are dissolved and the feeling of cooling is increased. Therefore, it is possible to obtain a very positive effect of improving the cooling sensation as the body temperature or temperature increases.

(B) Oil

Oil is used to prevent drying of the scalp and provide nutrients. Oils that can be used cannot be specified, and cosmetic oils are mostly suitable. More specifically, olive oil, avocado oil, almond oil, malt oil, apricot seed oil, walnut colostrum oil, rose hip oil, macadamia oil, cacao oil, peppermint oil, perm oil, camellia oil, cottonseed oil, safflower seed oil, grape seed oil, etc. Use above.

The oil in the hair tonic composition is suitably 1-5 wt%, more preferably 1-5 wt%. If it is less than 1 wt%, sufficient nutrient supply is difficult, and when it exceeds 5 wt%, the viscosity may be too high to be uncomfortable.

(C) emulsifier

Emulsifiers are used for the purpose of dispersing oil to make O/W emulsions into lotions. Most emulsifiers for cosmetics are suitable. More specifically, one or more selected from olive wax, emulsifying wax, candelilla wax, stearic acid, lecithin, cetos, and monta wax use.

The amount of the emulsifier is determined according to the amount of oil added. The emulsifier in the hair tonic composition is suitably 0.01-10 wt%, more preferably 0.5-5 wt%. If the content is less than 0.01 wt%, the emulsification is insufficient, and thus layer separation may occur. If the content exceeds 10 wt%, the viscosity may be too high, which may be inconvenient for use.

(D) Moisturizer

Moisturizer plays a role in preventing the skin from being moisturized or dried, and one or more are selected from glycerin, propylene glycol, butylene glycol, polyethylene glycol (PEG), sorbitol, hyaluronate, chondroitin sulfate, and low molecular collagen. It is used and usage is not limited.

(E) Active ingredients for hair growth

A number of compounds are known that promote blood circulation to the hair roots to facilitate the supply of nutrients, thereby providing a hair growth effect. The present invention uses at least one selected from minoxidil, Carpronium chloride (CPC), Benzylaminopurine (BAP), etc., which have been reported to promote hair circulation and promote hair growth, as an active ingredient for hair growth. The amount used depends on the recommended usage of each compound. For example, for minoxidil, 3% for women and 5% for men.

(F) solvent

In general, ethanol and purified water are used as a solvent for hair tonic. Ethanol can dry or damage the skin and cause fire and explosion. In other words, if you bring a hair tonic with a lot of ethanol in hot weather, an accident may occur by an explosion. Therefore, in the present invention, the content of ethanol is used at 0-20 wt% or less.

(G) Other ingredients

As other ingredients, extracts such as isoflavones, soybean extract, rat bean, ginseng, aronia, ginger, and loquat, which are vegetable extracts used as health functional food or cosmetic ingredients, may be additionally used.

Hereinafter, the present invention will be described in more detail through specific examples. The following examples are only examples for helping the understanding of the present invention, and the scope of the present invention is not limited thereto.

Examples 1-11 and Comparative Examples 1-11

<Manufacturing method>

Quantitative Beta-CD and cooling agent of each example were placed in a reaction vessel, half of the total purified water of each example was added, and then stirred at 70-80° C. for 1 hour with stirring to prepare a cooling agent/CD inclusion solution.

The composition (B), (C), (D), (E) and (G) of each example were put into a reaction vessel, half of the total purified water was added, and then stirred at 70-80° C. for 1 hour with stirring to obtain an emulsion. Make.

The above-mentioned separately prepared cooling agent/CD inclusion solution aqueous solution and ethanol are placed in a reaction container in which an emulsion is prepared, stirred at room temperature and mixed for 30 minutes to make a refreshing scalp nutrient. If necessary, the final product is completed through a fine grinding and stirring process with a homomixer or colloid mill at room temperature.

Table 1 shows the components of Example 1-11 of the present invention, and Table 2 shows the components of Comparative Example 1-11 of the present invention.

<Evaluation method>

0.1 ml of the composition of each Example and Comparative Example is taken and placed in each well of a 24-well dish and left for 2 hours in an incubator at 37° C. without closing the lid to allow evaporation. Next, add 1 ml of distilled water to each well, mix well, and seal it in a sample bottle.

First, the retention time of each sample is performed by performing LC/MS analysis on standard samples such as menthol, icilin, Frescolat MGA, Frescolat ML, Coolact 5, Coolact P, WS-3, WS-23, WS-14, and WS-5. Investigate (retention time). The amount of residual coolant was determined from the composition of each of the following Examples and Comparative Examples (initial sample) and the area of the peak appearing near the retention time of the sample after 2 hours of standing:

Residual refresher ratio (%) = (LC/MS peak area of sample after 2 hours of standing) x 100/(LC/MS peak area of initial sample)

<Results and Discussion>

As a result of examining the percentage (%) of the residual coolant in Examples and Comparative Examples, when the same refresher was used, the inclusion body containing beta-CD was higher.

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The embodiments of the present invention have been described above with reference to the accompanying drawings, but those of ordinary skill in the art to which the present invention pertains can be implemented in other specific forms without changing the present invention to its technical spirit or essential features. You will understand that there is. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive.

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Claims (9)

In the method for producing a composition for improving the condition of the hair or scalp,
The above method,
a) adding a refreshing agent and cyclodextrin (CD) to the solvent, and stirring the mixture under a temperature condition of 70°C to 80°C for 0.5 to 2 hours to prepare a cooling agent/CD inclusion solution solution;
b) adding an oil, an emulsifying agent, a moisturizing agent, and a hair growth active ingredient to a solvent and stirring for 0.5 to 2 hours under a temperature condition of 70°C to 80°C to prepare an emulsion; And
c) mixing the aqueous coolant/CD inclusion solution of step a), the emulsion of step b) and the solvent under normal temperature conditions for 15 minutes to 1 hour;
The refreshing agent is any one of menthol, icilin, menthol derivatives and carboxamide-based refreshing agents,
The coolant/CD inclusion body is a form in which the refreshing agent is enclosed in a ring of cyclodextrin,
With respect to the total weight of the composition, the refreshing agent is 0.01% to 3% by weight, the cyclodextrin is 0.01% to 3% by weight, the oil is 1% to 3% by weight, the emulsifying agent is 1% to 3% by weight, and the moisturizing agent 1% by weight to 3% by weight, the active ingredient for hair growth is 5% by weight to 15% by weight, a method for preparing a composition for improving hair or scalp condition.
delete delete According to claim 1,
A method for preparing a composition for improving hair or scalp condition, wherein the equivalent ratio of the cyclodextrin to the refreshing agent (equivalent ratio of CD/cooling agent) is an equivalent ratio of 0.01 to 4.
According to claim 1,
The active ingredient in hair growth is at least one selected from minoxidil, Carpronium chloride (CPC), Benzylaminopurine (BAP), flavanone, isoflavone, soybean extract, rat bean extract, ginseng extract, aronia extract, ginger extract and pipa extract, hair or Method of preparing a composition for improving the scalp condition.
delete According to claim 1,
The oil is at least one selected from olive oil, avocado oil, almond oil, malt oil, apricot seed oil, walnut colostrum oil, rose hip oil, macadamia oil, cacao oil, peppermint oil, perm oil, camellia oil, cottonseed oil, safflower seed oil and grape seed oil ,
The emulsifier is at least one selected from olive wax, emulsifying wax, candelilla wax, stearic acid, lecithin, cetos, and monta wax.
The humectant is at least one selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol (PEG),
The solvent is any one of water, a lower solvent of C1-5 and a mixed solvent of alcohol and water of C1-5, a method for preparing a composition for improving hair or scalp condition.
delete In the composition for improving the condition of hair or scalp, produced by the method of any one of claims 1, 4, 5, and 7,
The composition is a composition selected from the group consisting of hair tonic, hair nutrient makeup, scalp treatment, hair treatment, hair rinse, hair shampoo and hair lotion.

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