JP6179513B2 - Hair restorer composition - Google Patents

Hair restorer composition Download PDF

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JP6179513B2
JP6179513B2 JP2014523635A JP2014523635A JP6179513B2 JP 6179513 B2 JP6179513 B2 JP 6179513B2 JP 2014523635 A JP2014523635 A JP 2014523635A JP 2014523635 A JP2014523635 A JP 2014523635A JP 6179513 B2 JP6179513 B2 JP 6179513B2
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salicylate
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利江 廣畠
利江 廣畠
青野 恵
恵 青野
俊輔 廣島
俊輔 廣島
恭史 柿澤
恭史 柿澤
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Lion Corp
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Description

本発明は、清涼感と温感の両方を感じることができる育毛剤組成物に関する。   The present invention relates to a hair restorer composition capable of feeling both a refreshing feeling and a warm feeling.

育毛効果は、通常、育毛養毛剤を長期間に亘って継続使用することで得られるが、従来の育毛剤は、いずれも一回の使用で効果実感を得ることができず、長期使用に繋がっていないという問題があった。   The hair-growth effect is usually obtained by continuous use of a hair-growth nourishing agent over a long period of time, but none of the conventional hair-growth agents can achieve an effect when used once, leading to long-term use. There was no problem.

一方、育毛養毛剤を長期間使用しても、消費者が求めているレベルの育毛効果まで十分に達成できていないのが現状であった。
なお、本発明に関連する先行技術文献としては、下記のものが挙げられる。
On the other hand, even if the hair restoring agent is used for a long period of time, the level of hair restoring effect required by consumers has not been sufficiently achieved.
In addition, the following are mentioned as prior art documents relevant to the present invention.

特開2001−354579号公報JP 2001-354579 A

本発明は、上記事情に鑑みなされたもので、一度の塗布でも頭皮に十分な清涼感及び温感に由来する満足感を与え、血流量を向上させることができると共に、長期間に亘って使用したときの有効成分による育毛効果(抜け毛防止、発毛促進)に優れた育毛剤組成物を提供することを目的とする。   The present invention has been made in view of the above circumstances, and even when applied once, the scalp can be provided with a sufficient feeling of refreshment and warmth, can improve blood flow, and can be used over a long period of time. An object of the present invention is to provide a hair restorer composition excellent in hair growth effect (prevention of hair loss, promotion of hair growth) due to an active ingredient at the time.

本発明者らは、上記目的を達成するために鋭意検討した結果、(A)育毛有効成分、(D)エタノール、及び(E)精製水を含む育毛剤組成物に、(B)特定のサリチル酸誘導体と、(C)特定の清涼剤とを組み合わせて特定の割合で配合することで、驚くべきことに、後述する図1に示されるように、頭皮に塗布すると塗布直後は清涼感を強く感じられ、その後すぐに清涼感が弱まると共に温感が強くなるため、この清涼感と温感のバランスが一度の塗布でも使用者に対して従来にない高い満足感を与えることができることを見出すと共に、温感が継続するため頭皮の血流量を十分に上げることができることを見出した。しかも、このようにして得られる温感は、従来温感付与成分として用いられているトウガラシチンキ等のエキス類に比べて少量で強く感じられ、トウガラシチンキ等のように刺激を伴うことのない温感であることを見出し、本発明をなすに至った。   As a result of intensive studies to achieve the above object, the inventors of the present invention have (B) a specific salicylic acid in (B) a specific hair-recovery composition containing (A) a hair-growth active ingredient, (D) ethanol, and (E) purified water. Surprisingly, as shown in FIG. 1 to be described later, when a derivative is combined with (C) a specific refreshing agent and blended at a specific ratio, a refreshing feeling is felt immediately after application to the scalp. After that, since the refreshing feeling weakens and the warming feeling becomes stronger immediately after that, it is found that the balance between the refreshing feeling and the warm feeling can give the user a high satisfaction that has never been seen before, It has been found that the blood flow in the scalp can be sufficiently increased because the warm feeling continues. In addition, the warm feeling obtained in this way is felt in a small amount compared to extracts such as chili pepper tincture that have been used as a conventional warming ingredient, and is not accompanied by irritation such as chili pepper tincture. It was found to be a feeling and the present invention was made.

従って、本発明は、下記育毛剤組成物を提供する。
[1]
(A)6−ベンジルアミノプリン、ペンタデカン酸グリセリド、ミノキシジル、塩化カプロニウム、t−フラバノン及びオトギリソウエキスから選ばれる育毛有効成分:0.1〜5質量%と、
(B)サリチル酸グリコール、サリチル酸メチル、サリチル酸ジプロピレングリコール、サリチル酸オクチル、サリチル酸フェニル及びサリチル酸ホモメンチルから選ばれるサリチル酸誘導体:0.01〜5質量%と、
(C)l−メントール、メンチルグリセリルエーテル及びハッカ油から選ばれる清涼剤:0.01〜5質量%と、
(D)エタノール:55〜85質量%と、
(E)精製水:12〜43質量%
を含有し、(B)/(C)で示される含有質量比が0.5〜50であり、(D)/(E)で示される含有質量比が1.3〜4.4である育毛剤組成物。
[2]
(B)成分が、サリチル酸グリコール、サリチル酸メチル及びサリチル酸ジプロピレングリコールから選ばれる[1]記載の育毛剤組成物。
[3]
(A)成分の配合量が0.1〜3質量%である[1]又は[2]記載の育毛剤組成物。
[4]
更に、(F)トウガラシチンキ、ショウキョウエキス及びビワ葉エキスから選ばれる成分を含有する[1]〜[]のいずれかに記載の育毛剤組成物。
[5]
(F)トウガラシチンキの配合量が、エキス純分として0.00003質量%以上であり、(F)ショウキョウエキス及びビワ葉エキスの配合量が、エキス純分として0.0001質量%以上である[]記載の育毛剤組成物。
[6]
更に、(G)経皮吸収促進剤を含有する[1]〜[]のいずれかに記載の育毛剤組成物。
[7]
(G)成分が、平均分子量280〜420のポリエチレングリコールである[]記載の育毛剤組成物。
[8]
(G)成分の配合量が0.01〜5質量%である[]又は[]記載の育毛剤組成物。
[9]
塗布後0〜5分の間は清涼感を感じさせ、次いで、この清涼感が弱まると共に塗布後3〜7分の間は温感を感じさせ、その後継続して温感を感じさせる清涼感・温感育毛剤組成物である[1]〜[]のいずれかに記載の育毛剤組成物。
[10]
女性用の育毛トニック、頭皮用エッセンス、育毛スプレー又は育毛ヘアジェルである[1]〜[]のいずれかに記載の育毛剤組成物。
Accordingly, the present invention provides the following hair restorer composition.
[1]
(A) A hair-growth active ingredient selected from 6-benzylaminopurine, pentadecanoic acid glyceride, minoxidil, capronium chloride, t-flavanone and hypericum extract : 0.1 to 5% by mass ;
(B) Salicylic acid derivative selected from glycolic salicylate, methyl salicylate, dipropylene glycol salicylate, octyl salicylate, phenyl salicylate and homomenthyl salicylate : 0.01 to 5% by mass ;
(C) A refreshing agent selected from 1-menthol, menthyl glyceryl ether and mint oil : 0.01 to 5% by mass ;
(D) ethanol : 55-85% by mass ;
(E) Purified water : 12 to 43% by mass , the content mass ratio represented by (B) / (C) is 0.5 to 50, and the content mass represented by (D) / (E) A hair restorer composition having a ratio of 1.3 to 4.4.
[2]
(B) The hair restorer composition according to [1], wherein the component is selected from glycol salicylate, methyl salicylate, and dipropylene glycol salicylate.
[3]
(A) The hair restorer composition according to [1] or [2] , wherein the compounding amount of the component is 0.1 to 3% by mass.
[4]
Furthermore, (F) The hair restorer composition in any one of [1]-[ 3 ] containing the component chosen from a pepper tincture, a ginger leaf extract, and a loquat leaf extract.
[5]
(F) The amount of pepper tincture is 0.00003% by mass or more as a pure extract, and the amount of (F) pepper extract and loquat leaf extract is 0.0001% by mass or more as a pure extract. [ 4 ] The hair restorer composition according to [ 4 ].
[6]
Furthermore, (G) The hair restorer composition in any one of [1]-[ 5 ] containing a transdermal absorption promoter.
[7]
(G) The hair restorer composition according to [ 6 ], wherein the component is polyethylene glycol having an average molecular weight of 280 to 420.
[8]
(G) The hair restorer composition of [ 6 ] or [ 7 ] description whose compounding quantity of a component is 0.01-5 mass%.
[9]
A feeling of coolness is felt for 0 to 5 minutes after application, then this refreshing feeling is weakened and a feeling of warmth is felt for 3 to 7 minutes after application, and then a feeling of warmth is felt continuously. The hair restorer composition according to any one of [1] to [ 8 ], which is a warm hair restorer composition.
[10]
The hair-restoring agent composition according to any one of [1] to [ 9 ], which is a hair-growth tonic for women, an essence for scalp, a hair-growth spray, or a hair-growth hair gel.

本発明の育毛剤組成物は、頭皮に塗布した直後は清涼感を強く感じられ、その後すぐに清涼感が弱まると共に温感が強くなり、この清涼感と温感のバランスは一度の塗布でも使用者に高い満足感を与えることができる。また、この温感が継続するため頭皮の血流量を十分に上げることができる。しかも、本発明の組成物による温感はトウガラシチンキのような刺激を伴うことのない従来にない温感であり、長期間に亘って使用することで抜け毛を防止し、発毛を促進できる。   The hair restorer composition of the present invention gives a strong refreshing feeling immediately after being applied to the scalp, and immediately after that, the refreshing feeling weakens and the warmth becomes stronger, and the balance between this refreshing feeling and warmth is used even once. High satisfaction can be given to the person. Moreover, since this warm feeling continues, the blood flow volume of a scalp can fully be raised. Moreover, the warm sensation by the composition of the present invention is an unprecedented warm sensation that does not involve irritation such as chili pepper tincture, and can be used over a long period of time to prevent hair loss and promote hair growth.

清涼感及び温感の感じ方を示すグラフである。It is a graph which shows how to feel refreshing feeling and warm feeling.

本発明の組成物は、
(A)育毛有効成分、
(B)サリチル酸誘導体、
(C)清涼剤、
(D)エタノール、
(E)精製水
を含有する清涼感・温感育毛剤組成物である。
なお、本発明において、清涼感・温感育毛剤組成物とは、頭皮に塗布後まず清涼感を感じ、次に温感を感じることができる育毛剤組成物をいう。具体的には、清涼感を感じ始めるのは塗布後、0〜5分、特に0分以上3分未満が好ましく、温感を感じ始めるのは塗布後3〜7分、特に3〜5分であることが好ましい。
The composition of the present invention comprises:
(A) hair-growth active ingredient,
(B) a salicylic acid derivative,
(C) freshener,
(D) ethanol,
(E) A refreshing / warm hair-growing composition containing purified water.
In the present invention, the refreshing / warm hair-growing composition refers to a hair-growing composition that can first feel a refreshing feeling and then a warm feeling after being applied to the scalp. Specifically, it is 0 to 5 minutes after application, particularly 0 to less than 3 minutes after starting application, and 3 to 7 minutes after application, particularly 3 to 5 minutes after application. Preferably there is.

[(A)育毛有効成分]
本発明で用いられる(A)成分は、育毛効果(抜け毛防止、発毛促進)を有する公知の育毛有効成分であって、例えば、6−ベンジルアミノプリン、ペンタデカン酸グリセリド、ミノキシジル、塩化カプロニウム、t−フラバノン、オトギリソウエキス等が挙げられる。これらは1種単独で又は2種以上を適宜組み合わせて用いることができるが、育毛効果の点から、6−ベンジルアミノプリン、ペンタデカン酸グリセリド、ミノキシジルが好ましく、抜け毛改善、発毛促進効果の点から、より好ましくは6−ベンジルアミノプリン、ペンタデカン酸グリセリドである。
[(A) Hair-growth active ingredient]
The component (A) used in the present invention is a known hair-growth active ingredient having a hair-growth effect (hair loss prevention, hair growth promotion), such as 6-benzylaminopurine, pentadecanoic acid glyceride, minoxidil, capronium chloride, t -Flavanone, hypericum extract and the like. These can be used alone or in combination of two or more, but from the viewpoint of hair growth effect, 6-benzylaminopurine, pentadecanoic acid glyceride and minoxidil are preferable, from the viewpoint of hair loss improvement and hair growth promoting effect. More preferably, it is 6-benzylaminopurine or pentadecanoic acid glyceride.

(A)成分の配合量は、組成物全量に対して、抜け毛改善、発毛促進効果の点から、0.1〜5質量%が好ましく、より好ましくは0.5〜3質量%である。上記範囲とすることで抜け毛改善、発毛促進効果がより高まり、塗布時に地肌がべたつくのをより抑えることができる。   The blending amount of the component (A) is preferably 0.1 to 5% by mass and more preferably 0.5 to 3% by mass with respect to the total amount of the composition from the viewpoint of hair loss improvement and hair growth promoting effect. By setting it as the said range, hair loss improvement and the hair growth promotion effect increase more, and it can suppress that the background becomes sticky at the time of application | coating.

[(B)サリチル酸誘導体]
(B)サリチル酸誘導体を、下記(C)成分の清涼剤と組み合わせて所定の割合で配合することで、意外なことに、頭皮に対して最初に清涼感、次いで清涼感が弱まると共に温感を与えることができ、従来のトウガラシチンキ等の温感付与成分よりも少量で、しかも刺激を与えることなく、高い温感効果が得られ、頭皮に対する温感付与効果、血流量向上効果が飛躍的に向上する。(B)成分としては、例えば、サリチル酸グリコール、サリチル酸メチル、サリチル酸ジプロピレングリコール、サリチル酸オクチル、サリチル酸フェニル、サリチル酸ホモメンチル等に代表されるサリチル酸誘導体が挙げられる。これらは1種単独で又は2種以上を適宜組み合わせて用いることができるが、温感を付与し、血流量を向上させる点から、サリチル酸グリコール、サリチル酸メチル、サリチル酸ジプロピレングリコールが好ましく、より好ましくはサリチル酸グリコールである。
[(B) Salicylic acid derivative]
(B) By combining a salicylic acid derivative with a refreshing agent of the following component (C) at a predetermined ratio, surprisingly, the scalp first has a refreshing sensation and then a refreshing sensation and a warm feeling. It can be given in a smaller amount than conventional warming ingredients such as chili pepper tincture, and without causing irritation, a high warming effect can be obtained, and the warming imparting effect on the scalp and the blood flow improvement effect are dramatically improved improves. Examples of the component (B) include salicylic acid derivatives such as glycol salicylate, methyl salicylate, dipropylene glycol salicylate, octyl salicylate, phenyl salicylate, and homomenthyl salicylate. These can be used singly or in appropriate combination of two or more, but salicylate glycol, methyl salicylate and dipropylene glycol salicylate are preferred, more preferably from the viewpoint of imparting warmth and improving blood flow. Salicylic acid glycol.

(B)成分の配合量は、組成物全量に対して、温感の付与、血流量向上の点から、0.01〜5質量%が好ましく、より好ましくは0.3〜2質量%である。0.01質量%未満では、温感の付与、血流量向上効果が劣る場合があり、5質量%を超えると、地肌がべたつき、血流量の向上及び温感付与効果が劣る場合がある。   The blending amount of the component (B) is preferably 0.01 to 5% by mass, more preferably 0.3 to 2% by mass with respect to the total amount of the composition from the viewpoint of imparting warmth and improving blood flow. . If it is less than 0.01% by mass, the imparting of warmth and the effect of improving blood flow may be inferior, and if it exceeds 5% by mass, the background may be sticky, the improvement of blood flow and the effect of imparting warmth may be inferior.

[(C)清涼剤]
(B)成分と共に(C)成分を配合することで、上記したように、頭皮に対して清涼感及び温感を付与し、血流量を向上させる効果を格段に高めることができる。(C)成分としては、例えば、l−メントール、メンチルグリセリルエーテル、ハッカ油等が挙げられる。これらは1種単独で又は2種以上を適宜組み合わせて用いることができるが、温感付与、血流量向上の点から、l−メントールが好ましい。
[(C) Coolant]
By blending the component (C) together with the component (B), as described above, a refreshing feeling and a warm feeling can be imparted to the scalp, and the effect of improving the blood flow can be remarkably enhanced. Examples of the component (C) include l-menthol, menthyl glyceryl ether, mint oil and the like. These can be used singly or in appropriate combination of two or more, but l-menthol is preferable from the viewpoint of imparting warmth and improving blood flow.

(C)成分の配合量は、組成物全量に対して、温感付与、血流量向上の点から、0.01〜5質量%が好ましく、0.1〜2質量%がより好ましい。0.01質量%未満では、温感付与効果、血流量向上効果が劣る場合があり、5質量%を超えると温感付与効果が劣る場合がある。   The blending amount of the component (C) is preferably 0.01 to 5% by mass and more preferably 0.1 to 2% by mass with respect to the total amount of the composition in terms of imparting warmth and improving blood flow. If it is less than 0.01% by mass, the effect of imparting warmth and the effect of improving blood flow may be inferior, and if it exceeds 5% by mass, the effect of imparting warmth may be inferior.

ここで、(B)成分と(C)成分の配合割合は、(B)/(C)で示される、(C)成分に対する(B)成分の含有質量比が、温感、血流量向上の点から、0.5〜50であり、好ましくは1〜50であり、より好ましくは1.5〜20であり、2.5〜10が更に好ましい。この質量比が0.5未満の場合、血流量及び温感向上効果が劣り、50を超えても温感、血流量向上効果が劣る。   Here, the blending ratio of the component (B) and the component (C) is (B) / (C), and the content ratio of the component (B) to the component (C) is improved in warmth and blood flow. From a point, it is 0.5-50, Preferably it is 1-50, More preferably, it is 1.5-20, 2.5-10 is still more preferable. When this mass ratio is less than 0.5, the blood flow and warming effect are inferior, and when it exceeds 50, the warming and blood flow improving effect is poor.

[(D)エタノール]
(D)エタノールとしては、無水エタノールや95体積%エタノールを挙げることができる。頭皮に対する温感付与、血流量の向上の点から、組成物全量に対して無水エタノールとして55質量%以上が好ましく、より好ましくは60質量%以上である。上限は特に制限されないが、敏感な肌の人に対して刺激を与えない点から、85質量%以下、特に80質量%以下とすることもできる。なお、この配合量は、植物エキス等のエキス類を配合した場合、これらエキス類から持ち込まれるエタノールを含む配合量である。
[(D) ethanol]
(D) Examples of ethanol include absolute ethanol and 95% by volume ethanol. From the viewpoint of imparting warmth to the scalp and improving blood flow, 55% by mass or more is preferable as absolute ethanol with respect to the total amount of the composition, and more preferably 60% by mass or more. The upper limit is not particularly limited, but may be 85% by mass or less, particularly 80% by mass or less from the viewpoint of not stimulating a person with sensitive skin. In addition, this compounding quantity is a compounding quantity containing the ethanol brought in from these extracts, when extracts, such as a plant extract, are mix | blended.

[(E)精製水]
(E)精製水は、温感付与及び血流量向上の点から、組成物全量に対して12〜43質量%が好ましく、より好ましくは18〜37質量%である。上記範囲内とすることで、より温感が感じられ、血流量をより向上させることができる。なお、この配合量は、植物エキス等のエキス類を配合した場合、これらエキス類から持ち込まれる精製水を含む配合量である。
[(E) Purified water]
(E) Purified water is preferably 12 to 43% by mass, more preferably 18 to 37% by mass, based on the total amount of the composition, from the viewpoint of imparting warmth and improving blood flow. By setting it within the above range, a warmer feeling can be felt and the blood flow can be further improved. In addition, this compounding quantity is a compounding quantity containing the purified water brought in from these extracts, when extracts, such as a plant extract, are mix | blended.

ここで、(D)成分と(E)成分の好ましい配合割合は、温感、血流量向上の点から、(D)/(E)で示される、(E)成分に対する(D)成分の含有質量比が1.3〜4.4が好ましく、より好ましくは1.4〜4である。上記範囲内とすることで、血流量がより増加し、温感がより感じやすくなり、頭皮のべたつきを抑えることができる。この場合、本発明の育毛剤組成物は、特に使用実感でき、べたつきがなく、抜け毛防止効果に優れるため、男性用及び女性用として好適であり、特に温感付与効果に優れ、塗布時のべたつきがなく、毛髪をふんわりさせて量を多く見せることができるため、女性用として効果的である。   Here, the preferable blending ratio of the component (D) and the component (E) is the content of the component (D) with respect to the component (E) represented by (D) / (E) in terms of warmth and blood flow improvement. The mass ratio is preferably 1.3 to 4.4, more preferably 1.4 to 4. By setting it within the above range, the blood flow volume increases, the warmth is more easily felt, and the scalp can be prevented from sticking. In this case, the hair-restoring agent composition of the present invention is particularly suitable for men and women because it has a feeling of use, has no stickiness, and is excellent in preventing hair loss. It is effective for women, because it can soften hair and show a large amount.

[(F)エキス類]
本発明においては、上記(A)〜(E)成分に加え、温感、血流量及び育毛効果をより向上させるために、(F)エキス類を配合することができる。(F)成分としては、ショウキョウエキス、ビワ葉エキス、トウガラシチンキ等を1種単独で又は2種以上を適宜組み合わせて用いることができる。これらのエキスの中で、温感及び刺激感のなさからショウキョウエキス、ビワ葉エキスがより好ましい。これらのエキス類の抽出に用いる溶媒としては、特に限定されないが、水、メタノール、エタノール、プロパノール、イソプロパノール等の低級アルコール、1,3−ブチレングリコール、プロピレングリコール、ジプロピレングリコール、グリセリン等の多価アルコール、エチルエーテル、プロピルエーテル等のエーテル類、酢酸エチル、酢酸ブチル等のエステル類、アセトン、メチルエチルケトン等の極性有機溶媒、生理食塩水、リン酸緩衝液等が挙げられる。
[(F) Extracts]
In the present invention, in addition to the above components (A) to (E), (F) extracts can be blended in order to further improve warmth, blood flow and hair growth effect. (F) As a component, a shrimp extract, a loquat leaf extract, a red pepper tincture, etc. can be used individually by 1 type or in combination of 2 or more types as appropriate. Among these extracts, a pepper extract and a loquat leaf extract are more preferable because of lack of warmth and irritation. Solvents used for extraction of these extracts are not particularly limited, but are polyvalent, such as water, lower alcohols such as methanol, ethanol, propanol and isopropanol, 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin. Examples thereof include ethers such as alcohol, ethyl ether and propyl ether, esters such as ethyl acetate and butyl acetate, polar organic solvents such as acetone and methyl ethyl ketone, physiological saline, and phosphate buffer.

このような(F)成分の各エキス類としては、市販品を用いることができる。
ショウキョウエキスは、例えばファルコレックス ショウキョウE(ショウキョウエキス1.30質量%(エキス純分)、水69.45質量%、無水エタノール29.25質量%)(一丸ファルコス(株)製)、ショウキョウチンキ(ショウガ根エキス1.00質量%(エキス純分)、水25.74質量%、無水エタノール73.26質量%)(丸善製薬(株)製)等が挙げられる。
A commercial item can be used as each extract of such (F) component.
For example, Falco Rex Showa E (Showa Extract 1.30% by mass (pure extract), water 69.45% by mass, absolute ethanol 29.25% by mass) (Ichimaru Falcos Co., Ltd.), Ginger tincture (1.00% by mass of ginger root extract (pure extract), 25.74% by mass of water, 73.26% by mass of absolute ethanol) (manufactured by Maruzen Pharmaceutical Co., Ltd.) and the like.

ビワ葉エキスは、例えば、ビワ抽出液−J(ビワ葉エキス1.4質量%(エキス純分)、水49.3質量%、無水エタノール49.3質量%)、ビワ葉エキスCA(ビワ葉エキス1質量%(エキス純分)、1,3−ブチレングリコール99質量%)、ビワ抽出液BG−J(ビワ葉エキス1.5質量%(エキス純分)、水49.25質量%、1,3−ブチレングリコール49.25質量%)、ビワ抽出液LA(ビワ葉エキス0.96質量%(エキス純分)、水69.33質量%、無水エタノール29.71質量%)(いずれも丸善製薬(株)製)、ファルコレックス ビワリーフB(ビワ葉エキス1.5質量%(エキス純分)、水49.25質量%、1,3−ブチレングリコール49.25質量%)、ファルコレックス ビワリーフE(ビワ葉エキス1.58質量%(エキス純分)、水66.65質量%、エタノール31.77質量%)(いずれも一丸ファルコス(株)製)等が挙げられる。   The loquat leaf extract is, for example, loquat extract-J (loan leaf extract 1.4% by mass (pure extract), water 49.3% by mass, absolute ethanol 49.3% by mass), loquat leaf extract CA (lowa leaf). 1% by weight of extract (pure extract), 99% by weight of 1,3-butylene glycol), loquat extract BG-J (1.5% by weight of loquat leaf extract (pure extract), 49.25% by weight of water, 1 , 3-butylene glycol 49.25% by mass), loquat extract LA (0.96% by mass of loquat leaf extract (pure extract), 69.33% by mass of water, 29.71% by mass of absolute ethanol) (all are Maruzen) Manufactured by Pharmaceutical Co., Ltd.), Falco Rex Biwa Leaf B (1.5% by weight of Biwa leaf extract (extract), 49.25% by weight of water, 49.25% by weight of 1,3-butylene glycol), Falco Rex Biwa Leaf E (Biwa leaf d Kiss 1.58% by mass (extracted extract), water 66.65% by mass, ethanol 31.77% by mass) (all manufactured by Ichimaru Falcos Co., Ltd.) and the like.

トウガラシチンキは、例えばトウガラシチンキ(トウガラシ果実エキス0.30質量%(エキス純分)、無水エタノール99.7質量%)(丸善製薬(株)製)等が挙げられる。   Examples of the pepper tincture include chili pepper tincture (capsicum fruit extract 0.30 mass% (pure extract), anhydrous ethanol 99.7 mass%) (manufactured by Maruzen Pharmaceutical Co., Ltd.).

(F)成分を配合する場合、ショウキョウエキス、ビワ葉エキスについては、その配合量は、抜け毛改善、温感、血流量向上の点から、組成物全量に対して、エキス純分として0.0001質量%以上が好ましく、より好ましくは0.003質量%以上である。0.0001質量%以上とすることで血流量、温感をより向上させることができる。上限は特に制限されないが、刺激を生じさせない点から、エキス純分として0.07質量%以下が好ましく、0.05質量%以下がより好ましく、特に0.02質量%以下が好ましい。
また、トウガラシチンキについては、エキス純分として0.00003質量%以上が好ましく、より好ましくは0.0009質量%以上である。0.00003質量%以上とすることで温感をより向上させることができる。上限は特に制限されないが、刺激を生じさせない点から0.015質量%以下が好ましく、特に0.003質量%以下が好ましい。
When the component (F) is blended, with respect to the ginger leaf extract and loquat leaf extract, the blending amount is 0. 0 as the pure extract with respect to the total amount of the composition in terms of hair loss improvement, warmth and blood flow improvement. 0001 mass% or more is preferable, More preferably, it is 0.003 mass% or more. By setting it as 0.0001 mass% or more, a blood flow rate and a warm feeling can be improved more. The upper limit is not particularly limited, but is preferably 0.07% by mass or less, more preferably 0.05% by mass or less, and particularly preferably 0.02% by mass or less as a pure extract from the point of not causing irritation.
Moreover, about chili pepper tincture, 0.00003 mass% or more is preferable as an extract pure part, More preferably, it is 0.0009 mass% or more. A feeling of warmth can be improved more by setting it as 0.00003 mass% or more. The upper limit is not particularly limited, but is preferably 0.015% by mass or less, particularly preferably 0.003% by mass or less from the viewpoint of not causing irritation.

[(G)経皮吸収促進剤]
経皮吸収促進剤とは、(A)育毛有効成分の皮膚からの吸収を促進させる成分のことであり、血流量を促進させる作用もあり、具体的には、平均分子量190〜210のポリエチレングリコール200、平均分子量280〜320のポリエチレングリコール300、平均分子量380〜420のポリエチレングリコール400、平均分子量570〜630のポリエチレングリコール600、ジイソプロピルアジペート、レシチン、乳酸ミリスチル、乳酸ラウリル、乳酸エチル等の乳酸エステル類、モノカプリル酸等の中鎖脂肪酸のモノ、ジ又はトリグリセリド等が挙げられる。これらの中で、抜け毛改善、血流量の点から、平均分子量280〜320のポリエチレングリコール300、平均分子量380〜420のポリエチレングリコール400が好ましい。なお、本発明において、平均分子量の測定は、医薬部外品原料規格2006(薬事日報社)収載のポリエチレングリコール200の試験法(p1378)を準用する。
[(G) Transdermal absorption enhancer]
The transdermal absorption enhancer is a component that promotes absorption of (A) a hair-growth active ingredient from the skin, and also has an action of promoting blood flow, specifically, polyethylene glycol having an average molecular weight of 190 to 210. 200, polyethylene glycol 300 having an average molecular weight of 280-320, polyethylene glycol 400 having an average molecular weight of 380-420, polyethylene glycol 600 having an average molecular weight of 570-630, lactic acid esters such as diisopropyl adipate, lecithin, myristyl lactate, lauryl lactate and ethyl lactate And mono-, di- or triglycerides of medium chain fatty acids such as monocaprylic acid. Among these, polyethylene glycol 300 having an average molecular weight of 280 to 320 and polyethylene glycol 400 having an average molecular weight of 380 to 420 are preferable from the viewpoint of hair loss improvement and blood flow. In the present invention, the average molecular weight is measured by applying the test method (p1378) of polyethylene glycol 200 listed in the quasi-drug raw material standard 2006 (Pharmaceutical Daily).

(G)成分を配合する場合、その配合量は、組成物全量に対して抜け毛改善、育毛効果、血流量向上の点から0.01質量%以上が好ましく、より好ましくは0.3質量%以上である。上記範囲とすることで、血流量をより向上させ、経皮吸収促進効果をより高めることができる。上限は特に制限されないが、使用感上べたつきが生じない点から、5質量%以下、特に3質量%以下が好ましい。   (G) When mix | blending a component, the compounding quantity is 0.01 mass% or more from the point of hair loss improvement, the hair growth effect, and blood flow improvement with respect to the composition whole quantity, More preferably, it is 0.3 mass% or more. It is. By setting it as the said range, a blood flow rate can be improved more and the percutaneous absorption promotion effect can be heightened more. The upper limit is not particularly limited, but is preferably 5% by mass or less, and particularly preferably 3% by mass or less from the viewpoint that stickiness does not occur in terms of use.

[その他の成分]
本発明の育毛剤組成物には、本発明の効果を損なわない範囲で、通常育毛剤組成物に配合される上記成分以外の任意成分を1種単独で又は2種以上を適宜組み合わせて用いることができる。このような成分としては、ノニオン性界面活性剤、半極性界面活性剤、両性界面活性剤、アニオン性ポリマー、ノニオン性ポリマー、(G)成分以外のポリオール類、有機塩類、保湿剤、トニック剤、可溶化剤、ジブチルヒドロキシトルエンやα−トコフェロール等の酸化防止剤、トリクロサン、トリクロロカルバン等の殺菌剤、脂肪酸モノエタノールアミド、脂肪酸ジエタノールアミド等の粘度調整剤、紫外線吸収剤、酸化防止剤、タンパク誘導体、動植物抽出液、ピロクトンオラミン、ジンクピリチオン等のフケ防止剤、グリチルリチン酸ジカリウム等の抗炎症剤、安息香酸及びその塩、パラベン類、ケーソンCG等の防腐剤、クエン酸、トリエタノールアミン等のpH調整剤、エチレングリコールジ脂肪酸エステル等のパール化剤、乳濁剤、ハイドロトロープ、ビタミン類、揮発性油分、疎水性溶媒、希釈性溶媒、(F)成分以外のエキス類、色素、香料等を任意に添加することができる。
[Other ingredients]
In the hair restorer composition of the present invention, an optional component other than the above-mentioned components that are usually blended in the hair restorer composition is used alone or in combination of two or more, as long as the effects of the present invention are not impaired. Can do. Examples of such components include nonionic surfactants, semipolar surfactants, amphoteric surfactants, anionic polymers, nonionic polymers, polyols other than the component (G), organic salts, humectants, tonic agents, Solubilizers, antioxidants such as dibutylhydroxytoluene and α-tocopherol, bactericides such as triclosan and trichlorocarban, viscosity modifiers such as fatty acid monoethanolamide and fatty acid diethanolamide, UV absorbers, antioxidants, protein derivatives Animal and plant extracts, anti-dandruff agents such as piroctone olamine, zinc pyrithione, anti-inflammatory agents such as dipotassium glycyrrhizinate, benzoic acid and salts thereof, parabens, preservatives such as caisson CG, citric acid, triethanolamine, etc. pH adjusters, pearlizing agents such as ethylene glycol difatty acid esters, milk Agents, hydrotropes, vitamins, volatile oil, hydrophobic solvents, dilution solvents can optionally be added (F) extracts, other than the component, dyes, perfumes.

[用途]
本発明の育毛剤組成物(清涼感(冷感)・温感育毛剤組成物)は、育毛剤、養毛剤、血行促進剤、抜け毛改善剤として広く利用でき、特に育毛剤として使用することが好ましい。この場合、育毛トニック、頭皮用エッセンス、育毛スプレー、育毛ヘアジェル等の形態で外用に使用することができる。本発明の育毛剤組成物は、上記必須成分及び任意成分を混合して、常法に基づいて得ることができる。
[Usage]
The hair restorer composition (cool feeling (cool feeling) / warm hair restorer composition) of the present invention can be widely used as a hair restorer, a hair nourishing agent, a blood circulation promoter, and a hair loss improving agent, and is particularly preferably used as a hair restorer. . In this case, it can be used for external use in the form of a hair-growth tonic, scalp essence, hair-growth spray, hair-growth hair gel or the like. The hair restorer composition of the present invention can be obtained based on a conventional method by mixing the above essential components and optional components.

[容器、容器材質]
本発明の育毛剤組成物を充填する容器としては、アルミニウムラミネートチューブ、EVALチューブ、アルミニウムチューブ、ガラス蒸着プラスチックチューブ等のチューブの他、機械的又は差圧によるディスペンサー容器及びスクイーズ容器、ラミネートフィルム容器、スポイト容器、スティック容器、ボトル容器等が挙げられる。アルミニウムラミネートチューブのラミネートフィルムは、通常2層以上の多層を有し、その材質はポリエチレン、ポリエチレンテレフタレート、ポリエステル、二軸延伸ポリプロピレン、無延伸ポリプロピレン、ポリアクリロニトリル、エチレン酢酸ビニル共重合体等の合成樹脂、紙、アルミニウム蒸着プラスチック等によって構成されることが好ましい。強度、柔軟性、耐候性等を考慮し、一般的には2〜5層のものを用いることが好ましい。ボトルの材質としては、ポリエチレン、ポリプロピレン、ポリエチレンテレフタレート、ポリスチレン、ポリ塩化ビニル、エチレン−ビニルアルコール樹脂、アクリロニトリル・スチレン樹脂、ABS樹脂、ポリアミド、ガラス等を単層ないし2層以上組み合わせて用いることができる。
[Container, container material]
Examples of the container for filling the hair-restoring agent composition of the present invention include aluminum laminate tubes, EVAL tubes, aluminum tubes, glass-deposited plastic tubes, and the like, as well as dispenser containers and squeeze containers by mechanical or differential pressure, laminate film containers, A dropper container, a stick container, a bottle container, etc. are mentioned. The laminated film of aluminum laminated tube usually has two or more layers, and the material is synthetic resin such as polyethylene, polyethylene terephthalate, polyester, biaxially stretched polypropylene, unstretched polypropylene, polyacrylonitrile, ethylene vinyl acetate copolymer, etc. It is preferably made of paper, aluminum-deposited plastic, or the like. In consideration of strength, flexibility, weather resistance, etc., it is generally preferable to use 2-5 layers. As the bottle material, polyethylene, polypropylene, polyethylene terephthalate, polystyrene, polyvinyl chloride, ethylene-vinyl alcohol resin, acrylonitrile / styrene resin, ABS resin, polyamide, glass, etc. can be used in a single layer or in combination of two or more layers. .

以下、実施例及び比較例を示し、本発明を具体的に説明するが、本発明は下記の実施例に制限されるものではない。   EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

[実施例1〜56、比較例1〜5]
下記表に示す組成の育毛剤組成物を常法に準じて調製し、下記方法で評価した。結果を表中に併記する。なお、下記表中、テトラオレイン酸ポリオキシエチレン(40)ソルビットの( )内の数値はエチレンオキサイドの平均付加モル数を示す。(D)エタノール及び(E)精製水の配合量は、組成物中に含まれる全量を示す。なお、(D)エタノールは無水エタノールとしての量である。(A)〜(C)成分は純分換算量である。エキス類は、上段が有姿、下段がエキス純分の配合量をそれぞれ示す。実施例及び比較例の各組成物は全量が100質量%となるように配合した。
得られた実施例の育毛剤組成物はいずれも地肌のべたつきのないものであった。
[Examples 1 to 56, Comparative Examples 1 to 5]
A hair restorer composition having the composition shown in the following table was prepared according to a conventional method and evaluated by the following method. The results are also shown in the table. In addition, in the following table | surface, the numerical value in () of polyoxyethylene tetraoleate (40) sorbit shows the average addition mole number of ethylene oxide. The blending amount of (D) ethanol and (E) purified water indicates the total amount contained in the composition. In addition, (D) ethanol is the quantity as absolute ethanol. Components (A) to (C) are pure equivalents. In the case of extracts, the upper part is solid, and the lower part indicates the amount of pure extract. Each composition of an Example and a comparative example was mix | blended so that the whole quantity might be 100 mass%.
All of the hair restorer compositions of the obtained examples were not sticky to the background.

[抜け毛改善]
<評価方法>
50〜60歳代の女性40名に対して、育毛剤組成物を1回につき約1.5mLを1日2回(間隔をあけて1回ずつ合計2回使用)、1ヶ月間連続使用し、使用前に比べて使用後の抜け毛の本数が減ったか否かについて評価を行った。
<評価基準>
5点:40名中36名以上が、抜け毛が減ったと回答した
4点:40名中28名以上35名以下が、抜け毛が減ったと回答した
3点:40名中20名以上27名以下が、抜け毛が減ったと回答した
2点:40名中12名以上19名以下が、抜け毛が減ったと回答した
1点:40名中11名以下が、抜け毛が減ったと回答した
[Improve hair loss]
<Evaluation method>
For 40 women in their 50s and 60s, use about 1.5mL of hair restorer composition twice a day (twice at a time and once for a total of 2 times) and use continuously for 1 month. It was evaluated whether or not the number of hair loss after use decreased compared to before use.
<Evaluation criteria>
5 points: 36 or more out of 40 responded that hair loss was reduced. 4 points: 28 to 35 out of 40 responded that hair loss was reduced. 3 points: 20 to 27 or less out of 40 persons. 2 points: 12 to 19 out of 40 people answered that hair loss was reduced 1 point: 11 or less of 40 people answered that hair loss was reduced

[育毛効果]
<評価方法>
50〜60歳代の女性40名に対して、育毛剤組成物を1回につき約1.5mLを1日2回(間隔をあけて1回ずつ合計2回使用)、1ヶ月間連続使用し、使用前に比べて使用後の髪が増えたか否かについて評価を行った。
<基準>
5点:40名中36名以上が、髪が増えたと回答した
4点:40名中28名以上35名以下が、髪が増えたと回答した
3点:40名中20名以上27名以下が、髪が増えたと回答した
2点:40名中12名以上19名以下が、髪が増えたと回答した
1点:40名中11名以下が、髪が増えたと回答した
[Hair growth effect]
<Evaluation method>
For 40 women in their 50s and 60s, use about 1.5mL of hair restorer composition twice a day (twice at a time and once for a total of 2 times) and use continuously for 1 month. It was evaluated whether the hair after use increased compared to before use.
<Standard>
5 points: 36 or more out of 40 responded that their hair increased 4 points: 28 to 35 out of 40 responded that their hair increased 3 points: 20 or more out of 40 and 27 or less 2 points: 12 to 19 out of 40 people answered that hair increased 1 point: 11 or less of 40 people answered that hair increased

[血流量]
<評価方法>
40〜50歳代の女性被験者5名について、前腕内腹部2cm四方の特定部位に試料67μLを塗布し、3分後にレーザー血流量計OMEGAFLO(オメガウェーブ(株))を用いて血流量T1を測定した。試料を塗布する前(ブランク)の血流量(T0)と比較し、下記式にて血流量の増加率について算出して5名の平均値を求めた。
血流量の増加率={(T1−T0)/T0}×100(%)
<評価基準>
◎ :ブランクより血流量が30%以上50%以下増加した
◎〜○:ブランクより血流量が20%以上30%未満増加した
○ :ブランクより血流量が15%以上20%未満増加した
△ :ブランクより血流量が10%以上15%未満増加した
× :ブランクより血流量が10%未満増加もしくは変化なし
[Blood flow]
<Evaluation method>
For 5 female subjects in their 40s and 50s, 67 μL of sample was applied to a specific area 2 cm square on the forearm abdomen, and after 3 minutes, blood flow T1 was measured using a laser blood flow meter OMEGAFLO (Omega Wave Co., Ltd.). did. Compared with the blood flow volume (T0) before applying the sample (blank), the blood flow volume increase rate was calculated by the following formula, and the average value of 5 persons was obtained.
Increasing rate of blood flow = {(T1-T0) / T0} × 100 (%)
<Evaluation criteria>
◎: Blood flow increased by 30% or more and 50% or less than blank ◎ to ○: Blood flow increased by 20% or more but less than 30% than blank ○: Blood flow increased by 15% or more but less than 20% than blank △: Blank Blood flow increased more than 10% but less than 15% more than ×: Blood flow increased less than 10% or no change from blank

[温感]
<評価方法>
40〜60歳代の女性10名が、洗髪後のタオルドライの状態で試料を頭皮に約1.5mL塗布し、塗布後5分後の温感の有無を評価した。下記の評価基準で評価し、10名の平均値を算出した。
<評価基準>
非常に感じる :5点
かなり感じる :4点
感じる :3点
やや感じる :2点
感じない :1点
<判断基準>
4.5点以上5点以下:◎
4点以上4.5点未満:◎〜○
3点以上4点未満 :○
2点以上3点未満 :△
1点以上2点未満 :×
[Warm feeling]
<Evaluation method>
Ten women in their 40s and 60s applied about 1.5 mL of the sample to the scalp in a towel-dried state after shampooing, and evaluated the presence or absence of warm feeling 5 minutes after application. Evaluation was performed according to the following evaluation criteria, and an average value of 10 people was calculated.
<Evaluation criteria>
Very feel: 5 points Feel quite: 4 points Feel: 3 points Somewhat feel: 2 points Don't feel: 1 point
4.5 points or more and 5 points or less: ◎
4 or more and less than 4.5: ◎ to ○
3 points or more and less than 4 points: ○
2 points or more and less than 3 points: △
1 point or more and less than 2 points: ×

[清涼感]
<評価方法>
40〜60歳代の女性10名が、洗髪後のタオルドライの状態で試料を頭皮に約1.5mL塗布し、塗布直後〜5分以内の清涼感の有無を評価した。下記の評価基準で評価し、10名の平均値を算出した。
<評価基準>
非常に感じる :5点
かなり感じる :4点
感じる :3点
やや感じる :2点
感じない :1点
<判断基準>
4.5点以上5点以下:◎
4点以上4.5点未満:◎〜○
3点以上4点未満 :○
2点以上3点未満 :△
1点以上2点未満 :×
[Sensation of coolness]
<Evaluation method>
Ten women in their 40s to 60s applied about 1.5 mL of the sample to the scalp in a towel-dried state after shampooing, and evaluated the presence or absence of a refreshing feeling within 5 minutes immediately after application. Evaluation was performed according to the following evaluation criteria, and an average value of 10 people was calculated.
<Evaluation criteria>
Very feel: 5 points Feel quite: 4 points Feel: 3 points Somewhat feel: 2 points Don't feel: 1 point
4.5 points or more and 5 points or less: ◎
4 or more and less than 4.5: ◎ to ○
3 points or more and less than 4 points: ○
2 points or more and less than 3 points: △
1 point or more and less than 2 points: ×

被験者1名についての清涼感及び温感の感じ方の例を示すグラフを図1に示す。破線は清涼感、実線は温感を示す。   The graph which shows the example of how to feel the refreshing feeling and warmth about one test subject is shown in FIG. A broken line indicates a refreshing feeling and a solid line indicates a warm feeling.

[刺激感のなさ]
<評価方法>
40〜60歳代の女性10名が、洗髪後のタオルドライの状態で試料を頭皮に約1.5mL塗布し、塗布後の刺激感の有無を評価した。下記の評価基準で評価し、10名の平均値を算出した。
<評価基準>
全く感じない :5点
感じない :4点
やや感じない :3点
感じる :2点
非常に感じる :1点
<判断基準>
4.5点以上5点以下:◎
4点以上4.5点未満:◎〜○
3点以上4点未満 :○
2点以上3点未満 :△
1点以上2点未満 :×
[No sense of irritation]
<Evaluation method>
Ten women in their 40s and 60s applied about 1.5 mL of the sample to the scalp in a towel-dried state after washing the hair, and evaluated the presence or absence of irritation after application. Evaluation was performed according to the following evaluation criteria, and an average value of 10 people was calculated.
<Evaluation criteria>
I do not feel at all: 5 points I do not feel: 4 points I do not feel a little: 3 points I feel: 2 points I feel very much: 1 point
4.5 points or more and 5 points or less: ◎
4 or more and less than 4.5: ◎ to ○
3 points or more and less than 4 points: ○
2 points or more and less than 3 points: △
1 point or more and less than 2 points: ×

Figure 0006179513
Figure 0006179513

Figure 0006179513
Figure 0006179513

Figure 0006179513
Figure 0006179513

Figure 0006179513
Figure 0006179513

Figure 0006179513
Figure 0006179513

Figure 0006179513
Figure 0006179513

Figure 0006179513
Figure 0006179513

Figure 0006179513
Figure 0006179513

実施例及び比較例で使用した原料を下記に示す。

Figure 0006179513
The raw materials used in Examples and Comparative Examples are shown below.
Figure 0006179513

Claims (10)

(A)6−ベンジルアミノプリン、ペンタデカン酸グリセリド、ミノキシジル、塩化カプロニウム、t−フラバノン及びオトギリソウエキスから選ばれる育毛有効成分:0.1〜5質量%と、
(B)サリチル酸グリコール、サリチル酸メチル、サリチル酸ジプロピレングリコール、サリチル酸オクチル、サリチル酸フェニル及びサリチル酸ホモメンチルから選ばれるサリチル酸誘導体:0.01〜5質量%と、
(C)l−メントール、メンチルグリセリルエーテル及びハッカ油から選ばれる清涼剤:0.01〜5質量%と、
(D)エタノール:55〜85質量%と、
(E)精製水:12〜43質量%
を含有し、(B)/(C)で示される含有質量比が0.5〜50であり、(D)/(E)で示される含有質量比が1.3〜4.4である育毛剤組成物。
(A) A hair-growth active ingredient selected from 6-benzylaminopurine, pentadecanoic acid glyceride, minoxidil, capronium chloride, t-flavanone and hypericum extract : 0.1 to 5% by mass ;
(B) Salicylic acid derivative selected from glycolic salicylate, methyl salicylate, dipropylene glycol salicylate, octyl salicylate, phenyl salicylate and homomenthyl salicylate : 0.01 to 5% by mass ;
(C) A refreshing agent selected from 1-menthol, menthyl glyceryl ether and mint oil : 0.01 to 5% by mass ;
(D) ethanol : 55-85% by mass ;
(E) Purified water : 12 to 43% by mass , the content mass ratio represented by (B) / (C) is 0.5 to 50, and the content mass represented by (D) / (E) A hair restorer composition having a ratio of 1.3 to 4.4.
(B)成分が、サリチル酸グリコール、サリチル酸メチル及びサリチル酸ジプロピレングリコールから選ばれる請求項1記載の育毛剤組成物。   The hair restorer composition according to claim 1, wherein the component (B) is selected from glycol salicylate, methyl salicylate and dipropylene glycol salicylate. (A)成分の配合量が0.1〜3質量%である請求項1又は2記載の育毛剤組成物。 (A) The hair restorer composition of Claim 1 or 2 whose compounding quantity of a component is 0.1-3 mass%. 更に、(F)トウガラシチンキ、ショウキョウエキス及びビワ葉エキスから選ばれる成分を含有する請求項1〜のいずれか1項記載の育毛剤組成物。 Furthermore, the hair-restoring agent composition of any one of Claims 1-3 containing the component chosen from (F) chili pepper tincture, a ginger leaf extract, and a loquat leaf extract. (F)トウガラシチンキの配合量が、エキス純分として0.00003質量%以上であり、(F)ショウキョウエキス及びビワ葉エキスの配合量が、エキス純分として0.0001質量%以上である請求項記載の育毛剤組成物。 (F) The amount of pepper tincture is 0.00003% by mass or more as a pure extract, and the amount of (F) pepper extract and loquat leaf extract is 0.0001% by mass or more as a pure extract. The hair restorer composition according to claim 4 . 更に、(G)経皮吸収促進剤を含有する請求項1〜のいずれか1項記載の育毛剤組成物。 Furthermore, the hair restorer composition of any one of Claims 1-5 containing (G) transdermal absorption promoter. (G)成分が、平均分子量280〜420のポリエチレングリコールである請求項記載の育毛剤組成物。 The hair restorer composition according to claim 6 , wherein the component (G) is polyethylene glycol having an average molecular weight of 280 to 420. (G)成分の配合量が0.01〜5質量%である請求項又は記載の育毛剤組成物。 (G) The hair restorer composition of Claim 6 or 7 whose compounding quantity of a component is 0.01-5 mass%. 塗布後0〜5分の間は清涼感を感じさせ、次いで、この清涼感が弱まると共に塗布後3〜7分の間は温感を感じさせ、その後継続して温感を感じさせる清涼感・温感育毛剤組成物である請求項1〜のいずれか1項記載の育毛剤組成物。 A feeling of coolness is felt for 0 to 5 minutes after application, then this refreshing feeling is weakened and a feeling of warmth is felt for 3 to 7 minutes after application, and then a feeling of warmth is felt continuously. The hair restorer composition according to any one of claims 1 to 8 , which is a warm hair restorer composition. 女性用の育毛トニック、頭皮用エッセンス、育毛スプレー又は育毛ヘアジェルである請求項1〜のいずれか1項記載の育毛剤組成物。 The hair-growth composition according to any one of claims 1 to 9 , which is a hair-growth tonic for women, an essence for scalp, a hair-growth spray, or a hair-growth hair gel.
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