WO2013180157A1 - 乳化化粧料組成物 - Google Patents
乳化化粧料組成物 Download PDFInfo
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- WO2013180157A1 WO2013180157A1 PCT/JP2013/064861 JP2013064861W WO2013180157A1 WO 2013180157 A1 WO2013180157 A1 WO 2013180157A1 JP 2013064861 W JP2013064861 W JP 2013064861W WO 2013180157 A1 WO2013180157 A1 WO 2013180157A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Definitions
- the present invention relates to an emulsified cosmetic composition.
- ⁇ -gel is a hydrated crystal structure and has a lamellar structure. Most of stratum corneum intercellular lipids present in the outermost stratum corneum of skin have this ⁇ -gel structure, and at the same time it suppresses invasion of substances from the outside and moisture transpiration from the inside. , By itself retaining moisture, it has the function of maintaining the skin's flexibility and smooth appearance. In the skin, the stratum corneum retains about 33% of water in the form of bound water, and stratum corneum intercellular lipids are about 13% bound water (where bound water is bound to constituent molecules. (It is defined as water) (Non-patent Document 1).
- Patent Document 1 discloses an emulsified composition containing ceramide or the like known as stratum corneum intercellular lipid.
- Patent Document 1 describes that an emulsified composition having a high moisturizing effect can be obtained by dispersing ceramide having a lamellar ⁇ -gel structure in water. This is because ceramide, which is easily crystallized, has an ⁇ -gel structure, improves fluidity, and aims to penetrate into the skin.
- Patent Document 2 discloses a cosmetic comprising a combination of compounds that are considered to have high moisturizing properties, such as low-molecular compounds such as amino acids and high-molecular compounds such as hyaluronic acid.
- the present invention includes the following components (A), (B), (C) and (D): (A) Sphingosine, pseudo-sphingosine, salts thereof, one or more compounds selected from ionic surfactants 0.1% by weight or more and 15% by weight or less, (B) one or more compounds selected from monoglycerin difatty acid ester and sorbitan difatty acid ester, (C) 1 selected from ceramide, alcohol having 12 to 22 carbon atoms, fatty acid ester having 12 to 22 monoglycerin monocarbons, alkyl glyceryl ether having 12 to 22 monocarbons, and fatty acid ester having 12 to 22 sorbitan monocarbons A species or two or more compounds, (D) contains water, In component (A), (B), (C), (1) A / (B + C) weight ratio is 0.04 or more and 1 or less, (2) The molar fraction of B / (B + C) is 0.02 or more and 0.45 or less, (3) The present invention relates to an emuls
- the present invention forms a lamellar ⁇ -gel structure film on the skin surface over a long period of time when applied to the skin, and is held between the layers of the lamellar structure and bound water and free water (layers of the lamellar structure).
- the present invention relates to an emulsified cosmetic composition that retains water that is not bound to lamella structure constituents), causes moisture to remain in the skin for a long time, and improves the skin condition.
- the present inventors include one or more compounds selected from component (A) sphingosine, pseudo-sphingosine, salts thereof, and ionic surfactant, component (B) monoglycerin difatty acid ester, and sorbitan difatty acid ester.
- component (C) ceramide, higher alcohol, monoglycerin monofatty acid ester, monoalkyl glyceryl ether, sorbitan monofatty acid ester selected from one or two or more compounds in a specific range
- the emulsified cosmetic composition that, when applied to the skin, forms a film having a lamellar ⁇ -gel structure on the skin surface and leaves moisture on the skin for a long time to improve the skin condition. It was found that a product was obtained.
- the emulsified cosmetic composition of the present invention can form a film having a flexible lamellar ⁇ -gel structure composed of a low molecular weight compound on the skin surface when applied to the skin and dried. Furthermore, moisture and other active ingredients can be held between layers of a lamellar ⁇ -gel structure. As a result, the occlusiveness and barrier function of the skin can be assisted, and a moist feeling can be improved.
- Component (A) used in the present invention is one or more compounds selected from sphingosine, pseudo-sphingosine, salts thereof, and ionic surfactant.
- sphingosine and pseudo-type sphingosine include sphingosine represented by general formula (1).
- R 1 represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 4 to 30 carbon atoms, which may be substituted by a hydroxyl group, a carbonyl group or an amino group;
- each of X 1 , X 2 and X 3 independently represents a hydrogen atom, a hydroxyl group or an acetoxy group, and
- X 4 represents a hydrogen atom, an acetyl group or a glyceryl group Together with an adjacent oxygen atom to form an oxo group (provided that when Y is a methine group, one of X 1 and X 2 is a hydrogen atom and the other does not exist.
- X 4 is an oxo group
- X 3 is not present when R.sup.3 is present.
- R 2 and R 3 each independently represents a hydrogen atom, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group
- a R each independently represents a hydrogen atom.
- an amidino group or hydro A linear or branched saturated or unsaturated hydrocarbon group having a total of 1 to 8 carbon atoms which may have a substituent selected from a sil group, a hydroxyalkoxy group, an alkoxy group and an acetoxy group; 2 or 3 is shown; the broken line indicates that it may be an unsaturated bond)
- R 1 is a straight chain or branched chain having 4 to 30 carbon atoms, preferably 7 to 22 carbon atoms optionally substituted with a hydroxyl group, a carbonyl group or an amino group. It is a chain or cyclic saturated or unsaturated hydrocarbon group.
- a linear or branched alkyl group having 10 to 20 carbon atoms a linear or branched alkyl group having 10 to 20 carbon atoms having a hydroxyl group at the Y-side end, and a branched chain in the case of a branched alkyl group.
- a linear or branched alkyl group having 10 to 20 carbon atoms a linear or branched alkyl group having 10 to 20 carbon atoms having a hydroxyl group at the Y-side end
- a branched chain in the case of a branched alkyl group are preferably methyl-branched.
- a tridecyl group, a tetradecyl group, a pentadecyl group, a hexadecyl group, a 1-hydroxytridecyl group, a 1-hydroxypentadecyl group, an isohexadecyl group, and an isostearyl group are preferable.
- Y represents a methylene group (CH 2 ), a methine group (CH), or an oxygen atom.
- X 1 , X 2 and X 3 each independently represent a hydrogen atom, a hydroxyl group or an acetoxy group, and X 4 represents an oxo group together with a hydrogen atom, an acetyl group, a glyceryl group or an adjacent oxygen atom.
- the substituent which forms is shown.
- X 1 , X 2 , and X 3 are preferably those in which 0 to 1 are hydroxyl groups, the remainder is a hydrogen atom, and X 4 is a hydrogen atom.
- Y is a methine group, only one of X 1 and X 2 is a hydrogen atom, and the other does not exist. Also, when X 4 forms an oxo group, X 3 does not exist.
- R 2 and R 3 each independently represent a hydrogen atom, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group, and R 3 is preferably a hydrogen atom.
- A represents a number of 2 or 3
- R represents R 4 and R 5 when a is 2
- R represents R 4 , R 5 and R 6 when a is 3.
- R 4 , R 5 and R 6 are each independently a hydrogen atom or an amidino group, or may have a substituent selected from a hydroxyl group, a hydroxyalkoxy group, an alkoxy group and an acetoxy group. 1 to 8 linear or branched, saturated or unsaturated hydrocarbon groups.
- the hydroxyalkoxy group which can be substituted with a hydrocarbon group is preferably a linear or branched hydroxyalkoxy group having 1 to 7 carbon atoms.
- the alkoxy group is preferably a linear or branched alkoxy group having 1 to 7 carbon atoms.
- R 4 , R 5 and R 6 include, for example, a hydrogen atom; a linear or branched alkyl group such as methyl, ethyl, propyl, 2-ethylhexyl and isopropyl; an alkenyl group such as vinyl and allyl; an amidino group; Hydroxymethyl, 2-hydroxyethyl, 1,1-dimethyl-2-hydroxyethyl, 2-hydroxypropyl, 2,3-dihydroxypropyl, 2-hydroxy-3-methoxypropyl, 2,3,4,5,6- Pentahydroxyhexyl, 1,1-bis (hydroxymethyl) ethyl, 2- (2-hydroxyethoxy) ethyl, 2-methoxyethyl, 1-methyl-2-hydroxyethyl, 3-hydroxypropyl, 3-methoxypropyl, Hydroxyl groups such as 1,1-bis (hydroxymethyl) -2-hydroxyethyl, hydroxyalkoxy And a hydrocarbon group having 1 to 8 carbon atoms substituted
- a hydrogen atom or a hydroxyl group such as a methyl group, 2-hydroxyethyl, 1,1-dimethyl-2-hydroxyethyl, 1,1-bis (hydroxymethyl) ethyl, 2- (2-hydroxyethoxy) ethyl, etc.
- An alkyl group which may be substituted with 1 to 3 groups selected from a group and a hydroxyalkoxy group is preferred.
- sphingosine represented by the general formula (1) a naturally occurring sphingosine represented by the following general formula (2) or a compound having the same structure, and a derivative thereof (hereinafter referred to as a natural sphingosine) or a general formula.
- Pseudo-type sphingosine having a sphingosine structure represented by (3) (hereinafter referred to as pseudo-type sphingosine) is preferable.
- a natural sphingosine represented by the general formula (2) A natural sphingosine represented by the general formula (2).
- R 7 represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 7 to 19 carbon atoms which may be substituted by a hydroxyl group;
- Y 1 represents a methylene group or a methine group;
- X 5 , X 6 and X 7 each independently represent a hydrogen atom, a hydroxyl group or an acetoxy group, and
- X 8 represents a hydrogen atom or together with an adjacent oxygen atom, forms an oxo group ( However, when Y 1 is a methine group, one of X 5 and X 6 represents a hydrogen atom and the other does not exist.When X 8 forms an oxo group, X 7 does not exist.);
- R 8 Represents a hydroxymethyl group or an acetoxymethyl group;
- a R 1 s are each independently a hydrogen atom or an amidino group, or have a substituent selected from a hydroxyl group, a hydroxyalkoxy group,
- R 7 is preferably a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 7 to 19 carbon atoms, and a linear saturated or unsaturated hydrocarbon group having 13 to 15 carbon atoms. More preferred. a is preferably 2, and each R 1 independently represents a hydrogen atom or a linear or branched alkyl group having 1 to 4 carbon atoms.
- natural sphingosine represented by the general formula (2) include natural sphingosine, dihydrosphingosine, phytosphingosine, sphingadienin, dehydrosphingosine, dehydrophytosphingosine, and N-alkyl derivatives thereof (for example, N-methyl form) and the like.
- These sphingosines may be either natural (D (+)) optically active or non-natural (L ( ⁇ )) optically active, or a mixture of natural and non-natural types. May be used.
- the relative configuration of the above compound may be a natural configuration, a non-natural configuration other than that, or a mixture thereof.
- PHYTOSPHINGOSINE (INCI name: 8th Edition) and those represented by the following formula are more preferable.
- D-Sphingosine (4-Sphingenine) (SIGMA-ALDRICH), DS-phytosphingosine (DOOSAN), and phytosphingosine (Cosmo Farm).
- R 9 represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 10 to 22 carbon atoms which may be substituted by a hydroxyl group;
- X 9 represents a hydrogen atom, an acetyl group or A glyceryl group;
- a R 2 each independently represents a hydrogen atom or an amidino group, or a total carbon which may have a substituent selected from a hydroxyl group, a hydroxyalkoxy group, an alkoxy group and an acetoxy group A linear or branched saturated or unsaturated hydrocarbon group of the number 1 to 8 and a represents a number of 2 or 3)
- R 9 is preferably an iso-branched alkyl group having 14 to 20 carbon atoms, and more preferably an isostearyl group.
- the isostearyl group is more preferably an isostearyl group obtained by using, as a raw material oil, an isosteal alcohol derived from a by-product during the production of dimer acid using a fatty acid derived from an animal or vegetable oil.
- R 2 represents R 10 and R 11
- R 2 is R 10 , R 11, and R 12 .
- R 10 , R 11 and R 12 are, for example, a hydrogen atom; a linear or branched alkyl group such as methyl, ethyl, propyl, 2-ethylhexyl and isopropyl; an alkenyl group such as vinyl and allyl; an amidino group; Hydroxymethyl, 2-hydroxyethyl, 1,1-dimethyl-2-hydroxyethyl, 2-hydroxypropyl, 2,3-dihydroxypropyl, 2-hydroxy-3-methoxypropyl, 2,3,4,5,6- Pentahydroxyhexyl, 1,1-bis (hydroxymethyl) ethyl, 2- (2-hydroxyethoxy) ethyl, 2-methoxyethyl, 1-methyl-2-hydroxyethyl, 3-hydroxypropyl, 3-methoxypropyl, Hydroxyl groups such as 1,1-bis (hydroxymethyl) -2-hydroxyethyl, hydroxyalkoxy groups And an alkyl group having 1 to 8 carbon atoms in
- R 10 and R 11 are hydrogen atom, and the other is 2-hydroxyethyl, 1,1-dimethyl-2-hydroxyethyl, 1,1-bis (hydroxymethyl) ethyl, 2- ( A secondary amine which is 2-hydroxyethoxy) ethyl is preferred.
- R 9 is an isostearyl group
- X 9 is a hydrogen atom
- R 10 is a hydrogen atom
- R 11 is a 2-hydroxyethyl group, 1,1-bis (hydroxymethyl) ethyl group, 1,1 It is preferable that 1 to 3 selected from hydroxyl group and hydroxyalkoxy group such as dimethyl-2-hydroxyethyl group or 2- (2-hydroxyethoxy) ethyl group are substituted alkyl groups.
- Specific examples of the pseudo-sphingosine include the following pseudo-sphingosines (i) to (iv).
- these sphingosine and pseudo-sphingosine salts include acidic amino acid salts such as glutamic acid and aspartic acid; basic amino acid salts such as arginine; inorganic acid salts such as phosphoric acid and hydrochloric acid; monocarboxylic acid salts such as acetic acid; succinic acid Examples thereof include carboxylic acid salts such as citric acid, lactic acid, and malic acid, and one or more selected from these are preferable.
- examples of the ionic surfactant include anionic surfactants, cationic surfactants, and amphoteric surfactants.
- examples of the anionic surfactant include fatty acids having 12 to 22 carbon atoms such as sodium laurate, potassium palmitate and arginine stearate or salts thereof; alkyl sulfates having 12 to 22 carbon atoms such as sodium lauryl sulfate and potassium lauryl sulfate.
- the cationic surfactant is preferably a quaternary ammonium salt, for example, alkyltrimethylammonium chloride such as stearyltrimethylammonium chloride or lauryltrimethylammonium chloride; dialkyldimethylammonium chloride, trialkylmethylammonium chloride, alkylamine salt, etc. Is mentioned.
- alkyltrimethylammonium chloride such as stearyltrimethylammonium chloride or lauryltrimethylammonium chloride
- amphoteric surfactant examples include alkyl dimethylamine oxide, alkyl carboxy betaine, alkyl sulfo betaine, amide amino acid salt, alkyl amide propyl betaine, and alkyl amide propyl betaine is preferable.
- sphingosine, pseudo-sphingosine or a salt thereof, and an anionic surfactant are more preferable from the viewpoint of emulsion stability.
- sphingosine, pseudo-type sphingosine or salts thereof pseudo-type sphingosine (ii) (1- (2-hydroxyethylamino) -3-isostearyloxy-2-propanol or a salt thereof) is preferable from an economical viewpoint. .
- anionic surfactant examples include fatty acids having 12 to 22 carbon atoms or salts thereof, polyoxyethylene alkyl ether phosphoric acids having 12 to 22 carbon atoms or salts thereof, and sodium N-alkyloylmethyltaurine having 12 to 22 carbon atoms.
- fatty acids having 12 to 22 carbon atoms or salts thereof polyoxyethylene alkyl ether phosphoric acids having 12 to 22 carbon atoms or salts thereof
- sodium N-alkyloylmethyltaurine having 12 to 22 carbon atoms.
- One or more selected from acyl glutamates having 12 to 22 N carbon atoms are preferred, and acyl glutamic acids having 12 to 22 N carbon atoms or salts thereof are more preferable from the viewpoint of feeling in use.
- N-stearoyl-L-glutamate As the acyl glutamate having 12 to 22 carbon atoms, N-stearoyl-L-glutamate is preferable, N-stearoyl-L-glutamic acid arginine salt, and N-stearoyl-L-glutamic acid potassium salt are preferable.
- the component (A) one or more kinds can be used, and more specifically, one kind can be used alone or two or more kinds can be used in combination.
- N-stearoyl-L-glutamate, 1- (2-hydroxyethylamino) -3-isostearyloxy-2-propanol, POE (4) sodium lauryl ether phosphate, and phytosphingosine can be used alone. it can.
- 1- (2-hydroxyethylamino) -3-isostearyloxy-2-propanol and phytosphingosine may be used in combination
- N-stearoyl-L-glutamate and POE (4) lauryl ether phosphate Sodium may be used in combination
- sodium dilauroyl glutamate and N-stearoyl-L-glutamate may be used in combination.
- Component (A) can be used alone or in combination of two or more.
- the content of the component (A) indicates the content of the compound excluding the counter ion, and is 0.1% by weight or more in the total composition, more preferably 0.2% by weight or more, and 0.5% by weight. The above is more preferable. Moreover, it is 15 weight% or less, Furthermore, 5 weight% or less is preferable and 3 weight% or less is more preferable. Within these ranges, the components described below can be stably dispersed, and a non-sticky feeling can be obtained, which is preferable.
- the content of component (A) is 0.1 to 15% by mass in the total composition, preferably 0.2 to 5% by weight, more preferably 0.5 to 3% by weight.
- Component (B) used in the present invention is one or more compounds selected from monoglycerin difatty acid esters and sorbitan difatty acid esters.
- the monoglycerin difatty acid ester is preferably a monoglycerin difatty acid ester having 12 to 22 carbon atoms. Examples include acid esters, glycerin dioleic acid esters, and glycerin diisostearic acid esters.
- the sorbitan difatty acid ester is preferably a fatty acid ester having 12 to 22 sorbitan dicarbons such as sorbitan dilaurate, sorbitan dimyristate, sorbitan dipalmitate, sorbitan distearate, sorbitan dibehenate, sorbitan dioleate, and the like. It is done. Among these, glyceryl distearate and sorbitan distearate are preferable from the viewpoint of storage stability.
- the component (B) used in the present invention forms a lamellar structure by combining the component (A) and the component (C) described later.
- the content of the component (B) is preferably 0.1% by weight or more, more preferably 0.5% by weight or more, and further preferably 1% by weight or more. Moreover, 14.8 weight% or less is preferable, Furthermore, 5 weight% or less is more preferable, 3.2 weight% or less is further more preferable. If it is this range, it is excellent in stability and there is also little stickiness at the time of application
- the content of component (B) is preferably from 0.1 to 14.8% by weight, more preferably from 0.5 to 5% by weight, even more preferably from 1 to 3.2% by weight, based on the total composition.
- Component (C) used in the present invention includes ceramide, alcohol having 12 to 22 carbon atoms, fatty acid ester having 12 to 22 monoglycerin monocarbons, alkyl glyceryl ether having 12 to 22 monocarbons, and 12 to 22 sorbitan monocarbons. It is 1 type, or 2 or more types of compounds chosen from these fatty acid ester. In addition, with two or more types of compounds, for example, even compounds classified into the same ceramide are regarded as two or more types if the structures are different. Examples of the ceramide of component (C) used in the present invention include those represented by the general formula (4).
- R 11 represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 4 to 30 carbon atoms or a hydrogen atom, which may be substituted by a hydroxyl group, a carbonyl group or an amino group.
- Z represents a methylene group, a methine group or an oxygen atom
- X 11 , X 12 and X 13 each independently represent a hydrogen atom, a hydroxyl group or an acetoxy group
- X 14 represents a hydrogen atom, an acetyl group or a glyceryl group; or shown, together with the adjacent oxygen atom, forms an oxo group (provided that when Z is a methine group, either X 11 and X 12 is a hydrogen atom, is .X 14 to the other is not present X 13 is not present when forming an oxo group.)
- R 12 and R 13 each independently represent a hydrogen atom, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group
- R 14 is a hydroxyl group, a carbonyl A linear or branched or cyclic saturated or unsaturated carbon atom having 5 to 60 carbon atoms, which may have an ether bond, ester bond or
- a saturated or unsaturated hydrocarbon group of the chain (provided that when R 11 is a hydrogen atom and Z is an oxygen atom, R 15 is a hydrocarbon group having 10 to 30 carbon atoms in total, and R 11 is a hydrocarbon group; R 15 is a hydrocarbon group having 1 to 8 carbon atoms in total); the broken line portion may indicate an unsaturated bond)
- R 11 may be a hydroxyl group, a carbonyl group or an amino group, which may be substituted, preferably a straight chain having 4 to 30 carbon atoms, preferably a hydroxyl group optionally having 7 to 22 carbon atoms, A branched or cyclic saturated or unsaturated hydrocarbon group or a hydrogen atom.
- Z represents a methylene group, a methine group or an oxygen atom.
- X 11 , X 12 and X 13 each independently represent a hydrogen atom, a hydroxyl group or an acetoxy group.
- X 11 , X 12 and X 13 0 to 1 are preferably a hydroxyl group and the remainder is a hydrogen atom.
- Z is a methine group, only one of X 11 and X 12 is a hydrogen atom, and the other does not exist.
- X 14 is preferably a hydrogen atom or a glyceryl group.
- R 12 and R 13 each represent a hydrogen atom, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group, preferred R 12 is a hydrogen atom or a hydroxymethyl group, and preferred R 13 is a hydrogen atom.
- R 14 may be a hydroxyl group, a carbonyl group or an amino group, may be substituted, and the main chain may have an ether bond, an ester bond or an amide bond.
- a cyclic saturated or unsaturated hydrocarbon group is shown.
- the hydroxyl group or amino group may be substituted a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 35 carbon atoms, or a hydroxyl group at the ⁇ position of the hydrocarbon group
- a straight-chain, branched or cyclic saturated or unsaturated fatty acid having 8 to 22 carbon atoms which may be substituted is an ester bond or an amide bond.
- the fatty acid to be bonded is preferably isostearic acid, 12-hydroxystearic acid or linoleic acid.
- R 15 represents a hydrogen atom, or may have a substituent selected from a hydroxyl group, a hydroxyalkoxy group, an alkoxy group, and an acetoxy group. It is a saturated hydrocarbon group.
- R 11 is a hydrogen atom and Z is an oxygen atom
- R 15 is a hydrocarbon group having a total carbon number of 10 to 30.
- R 11 is a hydrocarbon group
- R 15 is a hydrocarbon group having 1 to 8 carbon atoms in total.
- the hydroxyalkoxy group and the alkoxy group are preferably those having 1 to 7 carbon atoms.
- the ceramide represented by the general formula (4) is preferably a ceramide represented by the following general formula (5) or (6).
- R 21 represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 7 to 19 carbon atoms which may be substituted by a hydroxyl group
- Z 1 represents a methylene group or a methine group
- X 15 , X 16 and X 17 each independently represent a hydrogen atom, a hydroxyl group or an acetoxy group
- X 18 represents a hydrogen atom or together with an adjacent oxygen atom, forms an oxo group.
- R 22 represents a hydroxymethyl group or an acetoxymethyl group
- R 23 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms
- R 24 has 5 to 30 carbon atoms which may be substituted by a hydroxyl group Linear, branched or cyclic saturated or unsaturated hydrocarbon groups Or a linear or branched saturated or unsaturated fatty acid having 8 to 22 carbon atoms which may be substituted with a hydroxyl group at the ⁇ -terminus of the alkyl group; Indicates that it may be an unsaturated bond.
- R 21 is a linear alkyl group having 7 to 19 carbon atoms, more preferably 13 to 15 carbon atoms;
- R 24 is a linear alkyl group having 9 to 27 carbon atoms which may be substituted by a hydroxyl group, or linoleic acid Is a straight-chain alkyl group having 9 to 27 carbon atoms bonded with an ester.
- X 18 preferably represents a hydrogen atom or forms an oxo group together with an oxygen atom.
- R 24 is preferably tricosyl, 1-hydroxypentadecyl, 1-hydroxytricosyl, heptadecyl, 1-hydroxyundecyl, or a nonacosyl group in which linoleic acid is ester-bonded to the ⁇ position.
- ceramide types 1 to 7 in which sphingosine, dihydrosphingosine, phytosphingosine or sphingadienin is amidated for example, J. Lipid Res., 24: 759 (1983), FIG. And J. Lipid. Res., 35: 2069 (1994), porcine and human ceramides described in FIG.
- N-alkyl compounds for example, N-methyl compounds
- These ceramides may be either natural (D ( ⁇ )) optically active or non-natural (L (+)) optically active, or a mixture of natural and non-natural. May be used.
- the relative configuration of the above compound may be a natural configuration, a non-natural configuration other than that, or a mixture thereof.
- compounds of CERAMIDE1, CERAMIDE2, CERAMIDE3, CERAMIDE5, CERAMIDE6II hereinafter referred to as INCI, 8th Edition
- INCI 8th Edition
- ceramides include Ceramide ⁇ I, Ceramide III, Ceramide IIIA, Ceramide IIIB, Ceramide IIIC, Ceramide VI (above, Cosmo Farm), Ceramide TIC-001 (Takasago Inc.), CERAMIDE ⁇ II (Quest International), DS-Ceramide VI, DS-CLA-Phytoceramide, C6-Phytoceramide, DS-ceramide Y3S (DOOSAN), CERAMIDE2 (Cedama).
- R 25 represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group or a hydrogen atom having 10 to 22 carbon atoms which may be substituted with a hydroxyl group
- X 19 represents a hydrogen atom
- R 26 is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 22 carbon atoms which may be substituted with a hydroxyl group or an amino group; Or a hydrocarbon group having an ester bond with a linear or branched saturated or unsaturated fatty acid having 8 to 22 carbon atoms which may be substituted with a hydroxyl group at the ⁇ -terminal
- R 27 represents a hydrogen atom Or a hydroxyl group, a hydroxyalkoxy group, an alkoxy group or an acetoxy group which may be substituted is an alkyl group having 1 to 30 carbon atoms in total.
- R 26 includes nonyl, tridecyl, pentadecyl, an undecyl group in which linoleic acid is ester-bonded to the ⁇ -position, a pentadecyl group in which linoleic acid is ester-bonded to the ⁇ -position, a pentadecyl group in which 12-hydroxystearic acid is ester-bonded to the ⁇ -position, An undecyl group in which methyl branched isostearic acid is amide-bonded at the ⁇ position is preferred.
- R 27 is an alkyl group having a total carbon number of 10 to 30, preferably a total carbon number of 12 to 20, which may be substituted by a hydroxyl group, a hydroxyalkoxy group, an alkoxy group or an acetoxy group.
- R 25 is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 10 to 22 carbon atoms which may be substituted by a hydroxyl group
- R 27 represents a hydrogen atom, It is preferably an alkyl group having 1 to 8 carbon atoms which may be substituted by a group, a hydroxyalkoxy group, an alkoxy group or an acetoxy group.
- the hydroxyalkoxy group or alkoxy group for R 27 those having 1 to 7 carbon atoms are preferred.
- R 25 is a hexadecyl group
- X 19 is a hydrogen atom
- R 26 is a pentadecyl group
- R 27 is a hydroxyethyl group
- R 25 is a hexadecyl group
- X 19 is a hydrogen atom
- R 26 is A pseudo-ceramide having a nonyl group and R 27 of hydroxyethyl group is preferred
- R 25 of the general formula (6) is a hexadecyl group
- X 19 is a hydrogen atom
- R 26 is a pentadecyl group
- R 27 is a hydroxyethyl group ( N- (hexadecyloxyhydroxypropyl) -N-hydroxyethylhexadecanamide) is more preferred.
- one or more ceramides can be used.
- Examples of the alcohol having 12 to 22 carbon atoms of component (C) include myristyl alcohol, cetanol, stearyl alcohol, behenyl alcohol, oleyl alcohol and the like. Of these, those having a linear alkyl group are preferred, more preferably alcohols having 16 to 22 carbon atoms, still more preferably alcohols having 16 to 18 carbon atoms, and even more preferably cetanol and stearyl alcohol.
- Examples of the fatty acid ester of 12 to 22 monoglycerin monocarbon of component (C) include glycerin monolaurate, glycerin monomyristic ester, glycerin monopalmitate, glycerin monostearate, glycerin monobehenate, Examples include glycerin monooleate and glycerin monoisostearate. Of these, fatty acid esters having 16 to 22 monoglycerol monocarbons are preferable, and glycerol monostearate and glycerol monobehenate are more preferable.
- Examples of the component (C) alkyl glyceryl ether having 12 to 22 mono carbon atoms include monodecyl glyceryl ether, monolauryl glyceryl ether, monomyristyl glyceryl ether, monocetyl glyceryl ether, monostearyl glyceryl ether, monobehenyl glyceryl ether and the like. Is mentioned. Of these, alkyl glyceryl ethers having 14 to 22 mono carbon atoms are preferred, and monostearyl glyceryl ether is more preferred.
- component (C) sorbitan monocarboxylic acid ester having 12 to 22 carbon atoms examples include sorbitan monolaurate, sorbitan monomyristate, sorbitan monopalmitate, sorbitan monostearate, sorbitan monobehenate and the like. Of these, fatty acid esters having 14 to 22 sorbitan monocarbons are preferred, and sorbitan monostearate is more preferred.
- component (C) from long-term storage stability and economical point of view, alcohol having 16 to 22 carbon atoms, fatty acid ester having 16 to 22 monoglycerin monocarbons, alkyl having 14 to 22 monocarbons. Glyceryl ether and sorbitan monofatty acid esters having 14 to 22 carbon atoms are preferred. Further, an alcohol having 16 to 22 carbon atoms and a fatty acid ester having 16 to 22 monoglycerol monocarbons are more preferable.
- the component (C) used in the present invention forms a lamellar structure by combining with the component (A) and the component (B).
- the content of the component (C) is preferably 0.2% by weight or more, more preferably 0.4% by weight or more, further preferably 0.7% by weight or more in the total composition. Moreover, 15 weight% or less is preferable, Furthermore, 12 weight% or less is more preferable, and 5 weight% or less is further more preferable. If it is this range, it is excellent in stability and there is also little stickiness at the time of application
- the content of component (C) is preferably 0.2 to 15% by weight, more preferably 0.4 to 12% by weight, and still more preferably 0.7 to 5% by weight in the total composition.
- a / (B + C) weight ratio is 0.04 or more and 1 or less
- the molar fraction of B / (B + C) is 0.02 or more and 0.45 or less
- the weight ratio of A / (B + C) indicates a range in which component (A) can stably emulsify components (B) and (C). Moreover, it has the function of maintaining the alignment of the molecules formed by the components (B) and (C) by electrostatic repulsion, which is important for forming a lamellar film. Further, when the composition of the present invention is applied to the skin, it plays a role of retaining the water of the component (D) and is important for maintaining the flexibility of the lamellar film formed on the skin surface. From the above viewpoint, the weight ratio of A / (B + C) is 0.04 or more, 1 or less, further preferably 0.5 or less, and more preferably 0.33 or less.
- the molar fraction of B / (B + C) is considered to be important for the arrangement of molecules formed by the components (B) and (C) to form a layered structure. From the above viewpoint, the molar fraction of B / (B + C) is 0.02 or more, 0.45 or less, further preferably 0.4 or less, and more preferably 0.35 or less.
- the maximum mole fraction occupied by one single component in the B + C component is considered to be necessary for stabilizing the layered structure because the arrangement of molecules formed by the components (B) and (C) forms a layered structure. It is done. More specifically, when a layered structure is formed, crystallization inside the layered structure is suppressed, and further, the fluidity of molecules in the layered structure is increased, and the flexibility of the film formed on the skin is maintained. There seems to be work. In addition, storage stability is improved. From the above viewpoint, the maximum mole fraction occupied by one compound single component in the B + C component is 0.2 or more, 0.8 or less, more preferably 0.75 or less, and more preferably 0.7 or less. preferable. From the same viewpoint, each component of components (B) and (C) is preferably one kind or a mixture of two or more kinds, and the compound species constituting components (B) and (C) Is preferably 3 or more, more preferably 4 or more.
- a component (B) + component (C) is 0.5 weight% or more in a whole composition from a moisture retention effect and a viewpoint of storage stability.
- 1% by weight or more is more preferable.
- 17 weight% or less is preferable, 10 weight% or less is more preferable, and 7 weight% or less is further more preferable.
- the total content of components (B) and (C) (component (B) + component (C)) is preferably 0.5 to 17% by weight, more preferably 1 to 17% by weight in the total composition, It is more preferably 1 to 10% by weight, still more preferably 1 to 7% by weight.
- the component (B) and (C) are composed of two or more compounds that can be used as the above components
- the component (B) And the average critical filling parameter of (C) is preferably 0.85 or more, more preferably 0.89 or more, further preferably 0.93 or more, preferably 1.1 or less, more preferably 1.07 or less. Preferably, it is 1.06 or less. Further, the average critical filling parameter of the components (B) and (C) is preferably 0.85 to 1.1, more preferably 0.89 to 1.07, and further preferably 0.93 to 1.06.
- the average critical filling parameter of components (B) and (C) is the critical filling parameter of each compound in a molar fraction where the sum of the compounds constituting component (B) and component (C) is 1. The sum of the values obtained by multiplying the mole fraction of each compound.
- the “critical packing parameter” means v / (l when the occupied volume of the hydrophobic group in the micelle shell is v, the length of the hydrophobic group is l, and the occupied area of the hydrophilic group at the micelle-solution interface is a.
- the critical packing parameter (hereinafter also referred to as “CPP”) is a general parameter for explaining the relationship between the molecular structure and the associating structure, and israelachvili shows the relationship between the critical packing parameter and the associating structure that can be taken stably.
- the ratio v / l of (hydrophobic group occupation volume / hydrophobic group length) is referred to as “hydrophobic group cross-sectional area” for convenience, and the critical packing parameter is (hydrophobic group cross-sectional area). / Occupied area of hydrophilic group).
- hydrophobic group cross-sectional area the ratio v / l of (hydrophobic group occupation volume / hydrophobic group length)
- the critical packing parameter is (hydrophobic group cross-sectional area). / Occupied area of hydrophilic group).
- the cross-sectional area (v / l) of the hydrophobic group is the cross-sectional area of 19.5 sq.
- Per alkyl chain from the direction perpendicular to the molecular axis in the ⁇ crystal of the aliphatic alcohol. Can be obtained by multiplying this by a correction coefficient (total carbon number of alkyl chain / maximum carbon number of alkyl chain).
- the cross-sectional area (a) of the hydrophilic group can be obtained by the following procedure. Search for possible conformations of a molecule in which the alkyl chain is replaced with the minimum length methyl group, calculate its conformational energy, and arrange in order of stability. Software such as Conflex (manufactured by Conflex) can be used for calculation of conformational search.
- those suitable for alignment at the interface that is, those having a smaller cross-sectional area in the major axis direction of the molecule and lower energy in the hydrated state are selected. Since the structure suitable for hydration of the polyoxyethylene chain is 7/2, the conformation is applied.
- a method such as COSMO method (A. Klamt and G. Schuurmann, J. Chem. Soc. Perkin Trans., 2 (1993) 799.) can be used.
- Calculating the van der Waals cross-sectional area of only the hydrophilic group when the molecule is projected in the long axis direction is taken as the cross-sectional area (a) of the hydrophilic group.
- the long axis of a molecule can be determined by calculating the moment of inertia of the molecular system.
- the Van der Waals cross section can be calculated from the ratio of points belonging to the cross section of the molecule to the points randomly generated in the rectangle by random numbers using a so-called Monte Carlo method by setting a rectangle circumscribing the cross section of the molecule.
- the critical filling parameter uses the average value.
- the water of component (D) is used as a solvent in the emulsified cosmetic composition, and the content is preferably 50% by weight or more, more preferably 60% by weight or more, and more preferably 98% by weight or less in the total composition. It is preferably 95% by weight or less, and is the balance of the above-mentioned components and other components constituting the emulsified cosmetic composition.
- the water content of component (D) is preferably from 50 to 98% by weight, more preferably from 60 to 95% by weight, based on the total composition.
- the emulsified cosmetic composition of the present invention can further contain a component (E) polyhydric alcohol.
- Polyhydric alcohol can improve the flexibility of the film formed on the skin surface when applied to the skin.
- examples of the polyhydric alcohol include glycerin, diglycerin, polyethylene glycol, 1,3-butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol and the like. These contents are preferably 1% by weight or more, more preferably 5% by weight, more preferably 30% by weight or less, and even more preferably 20% by weight or less in the total composition from the viewpoints of storage stability and usability.
- the content of the polyhydric alcohol is preferably 1 to 30% by weight and more preferably 5 to 20% by weight in the total composition.
- the emulsified cosmetic composition of the present invention can further contain a component (F) oily component.
- the oil component can improve the softness and smoothness of the film formed on the skin surface when applied to the skin.
- oily components include those other than the above-mentioned components, for example, hydrocarbon oils such as liquid paraffin, squalane and petrolatum; ether oils such as cetyldimethylbutyl ether, ethylene glycol dioctyl ether and glycerol monooleyl ether; octyldodecyl myristate, palmitic Isopropyl acid, butyl stearate, di-2-ethylhexyl adipate, neopentyl glycol dicaprate, trioctanoin, ester oils such as olive oil, etc .; higher fatty acids such as stearic acid, behenic acid, isomustic acid; dimethylpoly Siloxane, Cyclic dimethyl
- the content is preferably 1% by weight or more, preferably 20% by weight or less in the total composition, 15 More preferably, it is less than wt%. Further, the content of the oil component is preferably 1 to 20% by weight, more preferably 1 to 15% by weight in the total composition.
- the emulsified cosmetic composition of the present invention may further contain component (G) sterols.
- sterols include cholesterol and phytosterols.
- Phytosterol is a general term for plant sterols such as ⁇ -sitosterol, campesterol, stigmasterol, and brassicasterol, and the composition thereof is not particularly limited. These components can be used singly or in combination of two or more.
- the content is preferably 0.01% by weight or more in the total composition, and 0.1% by weight or more. Is more preferable, 2% by weight or less is preferable, and 0.5% by weight or less is more preferable.
- the content of sterols is preferably from 0.01 to 2% by weight, more preferably from 0.1 to 0.5% by weight, based on the total composition.
- the emulsified cosmetic composition of the present invention comprises active ingredients and additives used in normal cosmetics, for example, water-soluble vitamins such as ascorbic acid, nicotinic acid amide, and nicotinic acid; Extracts of animals and plants such as extracts, horsetail extracts, tea extracts, cucumber extracts, clove extracts, carrot extracts, hamamelis extracts, placenta extracts, seaweed extracts, maroni extract, yuzu extracts, asunalo extracts, royal jelly extracts, eucalyptus extracts, asunaro extracts Liquid: bases such as potassium hydroxide, sodium hydroxide, triethanolamine, sodium carbonate; acids such as citric acid, tartaric acid, lactic acid, phosphoric acid, succinic acid, adipic acid; carboxyvinyl polymer, sodium alginate, carrageenan, carboxymethyl Ceruleau Hydroxyethyl cellulose, guar gum, xanthan gum, carboxymethyl
- the emulsified cosmetic composition of the present invention has an ⁇ -gel ( ⁇ -type crystal) structure and suppresses precipitation of crystals ( ⁇ -type crystal).
- the ⁇ -gel can be confirmed by structural analysis using X-rays described later.
- the emulsified cosmetic composition of the present invention relates to the use for applying the emulsified cosmetic composition to the skin, drying it, forming a film having an ⁇ -gel structure on the skin surface, and moisturizing the skin.
- the emulsified cosmetic composition of the present invention relates to a method of applying an emulsified cosmetic composition to the skin, drying it, forming a film having an ⁇ -gel structure on the skin surface, and moisturizing the skin.
- the emulsified cosmetic composition of the present invention relates to use for producing a skin moisturizer.
- the present invention further discloses the following composition, production method, or application.
- the emulsified cosmetic composition of the present invention comprises the following components (A), (B), (C) and (D): (A) One or two or more compounds selected from sphingosine or a salt thereof, pseudo-type sphingosine or a salt thereof, and an ionic surfactant are preferably 0.1% by weight or more, more preferably 0.8%.
- One or more compounds selected from monoglycerin difatty acid ester and sorbitan difatty acid ester are preferably 0.1% by weight or more, more preferably 0.5% by weight or more, and still more preferably Is 1% by weight or more, preferably 14.8% by weight or less, more preferably 5% by weight or less, still more preferably 3.2% by weight or less,
- Species or two or more compounds are preferably 0.2% by weight or more, more preferably 0.4% by weight or more, still more preferably 0.7% by weight
- the ionic surfactant of component (A) is preferably a fatty acid having 12 to 22 carbon atoms or a salt thereof, a polyoxyethylene alkyl ether phosphoric acid having 12 to 22 carbon atoms or a salt thereof, or 12 to 12 carbon atoms.
- Component (A) is preferably one or more compounds selected from sphingosine or a salt thereof, 1- (2-hydroxyethylamino) -3-isostearyloxy-2-propanol or a salt thereof
- the content is preferably 0.1% by weight or more in the total composition, more preferably 0.2% by weight or more, still more preferably 0.5% by weight or more, and preferably 15% by weight or less.
- the component (B) is preferably one or more compounds selected from monoglycerin difatty acid esters, and the content is preferably 0.1% by weight or more in the total composition More preferably 0.5% by weight or more, more preferably 1% by weight or more, more preferably 14.8% by weight or less, more preferably 5% by weight or less, and still more preferably 3.2% by weight or less [1] to [5]
- the emulsified cosmetic composition according to any one of [5].
- Component (B) is preferably one or more compounds selected from sorbitan difatty acid esters, and the content is preferably 0.1% by weight or more in the total composition 0.5% by weight or more is more preferable, 1% by weight or more is more preferable, 14.8% by weight or less is preferable, 5% by weight or less is more preferable, and 3.2% by weight or less is more preferable [1] to [ [5]
- Component (C) is preferably an alcohol having 12 to 22 carbon atoms, more preferably one or more compounds selected from alcohols having 16 to 22 carbon atoms, The amount is preferably 0.2% by weight or more in the total composition, more preferably 0.4% by weight or more, still more preferably 0.7% by weight or more, preferably 15% by weight or less, and 12% by weight or less.
- the emulsified cosmetic composition according to any one of [1] to [9], more preferably 5% by weight or less.
- Component (C) is preferably a fatty acid ester having 12 to 22 monoglycerol monocarbons, more preferably one or two fatty acids selected from fatty acid esters having 16 to 22 monoglycerol monocarbons.
- the content of the compound is preferably 0.2% by weight or more, more preferably 0.4% by weight or more, still more preferably 0.7% by weight or more, and 15% by weight in the total composition.
- the emulsified cosmetic composition according to any one of [1] to [9], preferably 12% by weight or less, more preferably 5% by weight or less.
- Component (C) is preferably an alkyl glyceryl ether having 12 to 22 mono carbon atoms, more preferably one or more selected from alkyl glyceryl ethers having 14 to 22 mono carbon atoms.
- the content of the compound is preferably 0.2% by weight or more in the total composition, more preferably 0.4% by weight or more, further preferably 0.7% by weight or more, and 15% by weight or less.
- the emulsified cosmetic composition according to any one of [1] to [9], preferably 12% by weight or less, more preferably 5% by weight or less.
- the component (C) is preferably one or more compounds selected from fatty acid esters having 12 to 22 sorbitan monocarbons, and the content is preferably 0. 2 wt% or more, 0.4 wt% or more is more preferable, 0.7 wt% or more is more preferable, 15 wt% or less is preferable, 12 wt% or less is more preferable, and 5 wt% or less is more preferable
- the emulsified cosmetic composition according to any one of [9].
- the component (C) is preferably one or more compounds selected from monoglycerin mono-C12 fatty acid esters, and the content is preferably 0 in the total composition. .2% by weight or more, 0.4% by weight or more is more preferable, 0.7% by weight or more is more preferable, 15% by weight or less is preferable, 12% by weight or less is more preferable, and 5% by weight or less is more preferable.
- the emulsified cosmetic composition according to any one of [9].
- fatty acid ester having 12 to 22 monoglycerol monocarbons as component (C) is preferably glycerol monobehenate.
- the total content of components (B) and (C) is preferably 0.5% by weight or more, more preferably 1% by weight or more, and preferably 17% by weight or less in the total composition, 10% by weight.
- the emulsified cosmetic composition according to any one of [1] to [19], more preferably 7% by weight or less, and still more preferably 7% by weight or less.
- Examples 1 to 26 Comparative Examples 1 to 5 Emulsified cosmetic compositions having the compositions shown in Tables 2 to 4 were produced, and the structure breakage by X-ray, the structure breakage of the dried film by X-ray, storage stability, the persistence of moist feeling, and the sense of protection were evaluated. . The results are also shown in Tables 2 to 4.
- the critical packing parameter (CPP) and molecular weight of each compound in the component (B) are as shown in Table 1 below.
- phase I The ingredients of phase I are heated and mixed at 80 to 95 ° C., and then added with phase II heated to 80 to 95 ° C. with propeller stirring (300 rpm) and emulsified, and gradually cooled to 25 ° C. Thus, an emulsified cosmetic composition was obtained.
- the ⁇ -type structure is a hexagonal system, and the lipophilic group is oriented perpendicular to the surface of the hydrophilic base layer, and a sharp single diffraction peak appears in the vicinity of a Bragg angle of 21-23 °. is there.
- What was detected immediately after production was the result of “structural breakup by X-ray” in the following examples and comparative examples, and what was detected after the accelerated storage test was “structural breakup of dry film by X-ray”. It is a result.
- Example 27 skin lotion
- an emulsified cosmetic composition skin lotion having the composition shown in Table 5 was produced, and structural analysis was performed by X-rays to provide storage stability, durability of moist feeling, and protection. evaluated. The results are also shown in Table 5.
- Example 28 (milky lotion)
- an emulsified cosmetic composition (milky lotion) having the composition shown in Table 6 was produced, and the structural analysis was performed by X-ray to evaluate the storage stability, the persistence of moist feeling, and the sense of protection. did. The results are also shown in Table 6.
- Example 29 body lotion
- an oil-in-water emulsified cosmetic composition having the composition shown in Table 7 was produced and subjected to structural analysis by X-rays. Storage stability, moist feeling persistence and The sense of protection was evaluated. The results are also shown in Table 7.
- Example 30 (cream)
- an oil-in-water emulsified cosmetic composition (cream) having the composition shown in Table 8 was produced, structural analysis was performed by X-ray, storage stability, persistence of moist feeling, and protection The feeling was evaluated. The results are also shown in Table 8.
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Abstract
Description
一方、特許文献2には、アミノ酸等の低分子化合物、ヒアルロン酸等の高分子化合物など、保湿性が高いとされている化合物の組み合わせによる化粧料が開示されている。
(A)スフィンゴシン、擬似型スフィンゴシン、これらの塩、イオン性界面活性剤から選ばれる1種又は2種以上の化合物 0.1重量%以上15重量%以下、
(B)モノグリセリンジ脂肪酸エステル、ソルビタンジ脂肪酸エステルから選ばれる1種又は2種以上の化合物、
(C)セラミド、炭素数12~22のアルコール、モノグリセリンモノ炭素数12~22の脂肪酸エステル、モノ炭素数12~22のアルキルグリセリルエーテル、ソルビタンモノ炭素数12~22の脂肪酸エステルから選ばれる1種又は2種以上の化合物、
(D)水
を含有し、
成分(A)、(B)、(C)において、
(1)A/(B+C)の重量比が、0.04以上1以下、
(2)B/(B+C)のモル分率が0.02以上0.45以下、
(3)B+C構成成分中の1化合物単成分の占める最大モル分率が0.2以上0.8以下
である乳化化粧料組成物に関する。
本発明で用いる成分(A)は、スフィンゴシン、擬似型スフィンゴシン、これらの塩、イオン性界面活性剤から選ばれる1種又は2種以上の化合物である。なお、ここで、2種以上の化合物とは、例えば、同じイオン性界面活性剤に分類される化合物であっても、構造が異なれば2種以上とみなす。
本発明で用いる成分(A)の化合物のうち、スフィンゴシン、擬似型スフィンゴシンとしては、一般式(1)で表わされるスフィンゴシンが挙げられる。
X1、X2、及びX3は、各々独立して水素原子、ヒドロキシル基又はアセトキシ基を示し、X4は、水素原子、アセチル基、グリセリル基、隣接する酸素原子と一緒になってオキソ基を形成する置換基を示す。X1、X2、及びX3のうち0~1個がヒドロキシル基で、残余が水素原子、及びX4が水素原子であるものが好ましい。なお、Yがメチン基のとき、X1とX2のいずれか一方のみが水素原子であり、他方は存在しない。また、X4がオキソ基を形成するとき、X3は存在しない。
また、aは2又は3の数を示し、aが2のときRはR4及びR5を示し、aが3のときRはR4、R5及びR6を示す。
R4、R5及びR6としては、例えば、水素原子;メチル、エチル、プロピル、2-エチルへキシル、イソプロピル等の直鎖又は分岐鎖アルキル基;ビニル、アリル等のアルケニル基;アミジノ基;ヒドロキシメチル、2-ヒドロキシエチル、1,1-ジメチル-2-ヒドロキシエチル、2-ヒドロキシプロピル、2,3-ジヒドロキシプロピル、2-ヒドロキシ-3-メトキシプロピル、2,3,4,5,6-ペンタヒドロキシへキシル、1,1-ビス(ヒドロキシメチル)エチル、2-(2-ヒドロキシエトキシ)エチル、2-メトキシエチル、1-メチル-2-ヒドロキシエチル、3-ヒドロキシプロピル、3-メトキシプロピル、1,1-ビス(ヒドロキシメチル)-2-ヒドロキシエチル等のヒドロキシル基、ヒドロキシアルコキシ基及びアルコキシ基から選ばれる1~6個が置換した総炭素数1~8の炭化水素基が挙げられる。
(I)一般式(2)で表わされる天然型スフィンゴシン。
これらのスフィンゴシンは天然型(D(+)体)の光学活性体を用いても、非天然型(L(-)体)の光学活性体を用いても、更に天然型と非天然型の混合物を用いてもよい。上記化合物の相対立体配置は、天然型の立体配置のものでも、それ以外の非天然型の立体配置のものでも良く、また、これらの混合物によるものでもよい。
これらのうち、PHYTOSPHINGOSINE(INCI名;8th Edition)及び次式で表わされるものがより好ましい。
また、aが2のときR2はR10及びR11を示し、aが3のときR2はR10、R11及びR12である。
これらのうち、R10及びR11のいずれか1つが水素原子で、他方が2-ヒドロキシエチル、1,1-ジメチル-2-ヒドロキシエチル、1,1-ビス(ヒドロキシメチル)エチル、2-(2-ヒドロキシエトキシ)エチルである2級アミンが好ましい。
擬似型スフィンゴシンの具体例としては、次の擬似型スフィンゴシン(i)~(iv)が挙げられる。
アニオン界面活性剤としては、例えば、ラウリン酸ナトリウム、パルミチン酸カリウム、ステアリン酸アルギニン等の炭素数12~22の脂肪酸又はその塩;ラウリル硫酸ナトリウム、ラウリル硫酸カリウム等の炭素数12~22のアルキル硫酸エステル又はその塩;ポリオキシエチレンラウリル硫酸トリエタノールアミン等の炭素数12~22のアルキルエーテル硫酸エステル又はその塩;ラウロイルサルコシンナトリウム等のN-炭素数12~22のアシルサルコシン又はその塩;モノステアリルリン酸ナトリウム等の炭素数12~22のアルキルリン酸又はその塩;ポリオキシエチレンオレイルエーテルリン酸ナトリウム、ポリオキシエチレンステアリルエーテルリン酸ナトリウム等のポリオキシエチレン炭素数12~22のアルキルエーテルリン酸又はその塩;ジ-2-エチルヘキシルスルホコハク酸ナトリウム等の炭素数12~24のジアルキルスルホコハク酸又はその塩;N-ステアロイル-N-メチルタウリンナトリウム等の炭素数12~22のN-アルキロイルメチルタウリン又はその塩;ジラウロイルグルタミン酸ナトリウム、N-ラウロイルグルタミン酸モノナトリウム、N-ステアロイル-L-グルタミン酸ナトリウム、N-ステアロイル-L-グルタミン酸アルギニン、N-ステアロイルグルタミン酸ナトリウム、N-ミリストイル-L-グルタミン酸ナトリウム等のN-炭素数12~22のアシルグルタミン酸又はその塩などが挙げられる。これらのうち、炭素数12~22の脂肪酸又はその塩、ポリオキシエチレン炭素数12~22のアルキルエーテルリン酸又はその塩、炭素数12~22のN-アルキロイルメチルタウリン又はその塩、N-炭素数12~22のアシルグルタミン酸又はその塩が好ましい。
本発明で用いる成分(B)は、モノグリセリンジ脂肪酸エステル、ソルビタンジ脂肪酸エステルから選ばれる1種又は2種以上の化合物である。なお、2種以上の化合物とは、例えば、モノグリセリンジ脂肪酸エステルに分類される化合物であっても、構造が異なれば2種以上とみなす。
モノグリセリンジ脂肪酸エステルとしては、モノグリセリンジ炭素数12~22の脂肪酸エステルが好ましく、例えば、グリセリンジラウリン酸エステル、グリセリンジミリスチン酸エステル、グリセリンジパルミチン酸エステル、グリセリンジステアリン酸エステル、グリセリンジベヘン酸エステル、グリセリンジオレイン酸エステル、グリセリンジイソステアリン酸エステル等が挙げられる。
ソルビタンジ脂肪酸エステルとしては、ソルビタンジ炭素数12~22の脂肪酸エステルが好ましく、例えば、ジラウリン酸ソルビタン、ジミリスチン酸ソルビタン、ジパルミチン酸ソルビタン、ジステアリン酸ソルビタン、ジベヘン酸ソルビタン、ジオレイン酸ソルビタン等が挙げられる。
これらの中で、保存安定性の点から、グリセリンジステアリン酸エステル、ジステアリン酸ソルビタンが好ましい。
本発明で用いる成分(C)は、セラミド、炭素数12~22のアルコール、モノグリセリンモノ炭素数12~22の脂肪酸エステル、モノ炭素数12~22のアルキルグリセリルエーテル、ソルビタンモノ炭素数12~22の脂肪酸エステルから選ばれる1種又は2種以上の化合物である。なお、2種以上の化合物とは、例えば、同じセラミドに分類される化合物であっても構造が異なれば2種以上とみなす。
本発明で用いる成分(C)のセラミドとしては、一般式(4)で表わされるものが挙げられる。
Zはメチレン基、メチン基又は酸素原子のいずれかを示す。
R12及びR13は、水素原子、ヒドロキシル基、ヒドロキシメチル基又はアセトキシメチル基を示し、好ましいR12は水素原子又はヒドロキシメチル基であり、好ましいR13は水素原子である。
(I)一般式(5)で表わされる天然由来のセラミド又は同構造の合成物及びその誘導体(以下、天然型セラミドと記載する。)。
これらのセラミドは天然型(D(-)体)の光学活性体を用いても、非天然型(L(+)体)の光学活性体を用いても、更に天然型と非天然型の混合物を用いてもよい。上記化合物の相対立体配置は、天然型の立体配置のものでも、それ以外の非天然型の立体配置のものでも良く、また、これらの混合物によるものでもよい。これらのうち、CERAMIDE1、CERAMIDE2、CERAMIDE3、CERAMIDE5、CERAMIDE6IIの化合物(以上、INCI、8th Edition)及び次式で表わされるものが好ましい。
(1)A/(B+C)の重量比が、0.04以上1以下、
(2)B/(B+C)のモル分率が0.02以上0.45以下、
(3)B+C構成成分中の1化合物単成分の占める最大モル分率が0.2以上0.8以下の関係を満たすことが重要である。
なお、成分(B)と(C)の平均臨界充填パラメータとは、成分(B)及び成分(C)を構成する化合物の合計を1とするモル分率において、各化合物の有する臨界充填パラメータに各化合物のモル分率を掛け合わせ、得られた値の総和をいう。
本発明において平均臨界充填パラメータの計算は以下のように行った。
アルキル鎖を最低の長さのメチル基に置き換えた分子の可能な配座を探索して、その配座エネルギーを計算し、その安定な順に並べる。配座探索の計算にはConflex(コンフレックス社製)などのソフトウエアを用いることができる。
平均臨界充填パラメータ=B1の臨界充填パラメータ×B1のモル分率+B2の臨界充填パラメータ×B2のモル分率により、計算される。
多価アルコールとしては、例えば、グリセリン、ジグリセリン、ポリエチレングリコール、1,3-ブチレングリコール、イソプレングリコール、プロピレングリコール、ジプロピレングリコールなどが挙げられる。
これらの含有量は、保存安定性、使用感の点から、全組成中に1重量%以上が好ましく、5重量%がより好ましく、30重量%以下が好ましく、20重量%以下がより好ましい。また、多価アルコールの含有量は、全組成中に1~30重量%が好ましく、5~20重量%がより好ましい。
油性成分としては、前記成分以外のもので、例えば、流動パラフィン、スクワラン、ワセリン等の炭化水素油;セチルジメチルブチルエーテル、エチレングリコールジオクチルエーテル、グリセロールモノオレイルエーテル等のエーテル油;ミリスチン酸オクチルドデシル、パルミチン酸イソプロピル、ステアリン酸ブチル、アジピン酸ジ-2-エチルヘキシル、ジカプリン酸ネオペンチルグリコール、トリオクタノイン、オリーブ油等の植物油等のエステル油;ステアリン酸、ベヘン酸、イソミリスチン酸等の高級脂肪酸;ジメチルポリシロキサン、環状ジメチルポリシロキサン、メチルフェニルポリシロキサン、アミノ変性シリコーン、カルボキシ変性シリコーン、アルコール変性シリコーン、アルキル変性シリコーン、ポリエーテル変性シリコーン、フッ素変性シリコーン等のシリコーン油;パーフルオロアルキルエチルリン酸、パーフルオロアルキルポリオキシエチレンリン酸、パーフルオロポリエーテル、ポリテトラフルオロエチレン等のフッ素系油などが挙げられる。
これらの油性成分は、1種又は2種以上を組み合わせて用いることができ、保存安定性の点から、含有量は、全組成中に1重量%以上が好ましく、20重量%以下が好ましく、15重量%以下がより好ましい。また、油性成分の含有量は、全組成中に1~20重量%が好ましく、1~15重量%がより好ましい。
これらの成分は、1種又は2種以上を組み合わせて用いることができ、水分保持能を高める点から、含有量は、全組成中に0.01重量%以上が好ましく、0.1重量%以上がより好ましく、2重量%以下が好ましく、0.5重量%以下がより好ましい。また、ステロール類の含有量は、全組成中に0.01~2重量%が好ましく、0.1~0.5重量%がより好ましい。
上述した実施形態に関し、本発明はさらに以下の組成物、製造方法、或いは用途を開示する。
(A)スフィンゴシン又はその塩、擬似型スフィンゴシン又はその塩、及びイオン性界面活性剤から選ばれる1種又は2種以上の化合物 0.1重量%以上15重量%以下、
(B)モノグリセリンジ脂肪酸エステル、ソルビタンジ脂肪酸エステルから選ばれる1種又は2種以上の化合物、
(C)セラミド、炭素数12~22のアルコール、モノグリセリンモノ炭素数12~22の脂肪酸エステル、モノ炭素数12~22のアルキルグリセリルエーテル、ソルビタンモノ炭素数12~22の脂肪酸エステルから選ばれる1種又は2種以上の化合物、
(D)水
を含有し、
成分(A)、(B)、(C)において、
(1)A/(B+C)の重量比が、0.04以上1以下、
(2)B/(B+C)のモル分率が0.02以上0.45以下、
(3)B+C構成成分中の1化合物単成分の占める最大モル分率が0.2以上0.8以下
である乳化化粧料組成物。
(A)スフィンゴシン又はその塩、擬似型スフィンゴシン又はその塩、及びイオン性界面活性剤から選ばれる1種又は2種以上の化合物を、好ましくは0.1重量%以上であり、より好ましくは0.2重量%以上、更に好ましくは0.5重量%以上、好ましくは、15重量%以下であり、より好ましくは5重量%以下、更に好ましくは3重量%以下、
(B)モノグリセリンジ脂肪酸エステル、ソルビタンジ脂肪酸エステルから選ばれる1種又は2種以上の化合物を、好ましくは、0.1重量%以上であり、より好ましくは0.5重量%以上、更に好ましくは1重量%以上、好ましくは14.8重量%以下であり、より好ましくは5重量%以下、更に好ましくは3.2重量%以下、
(C)セラミド、炭素数12~22のアルコール、モノグリセリンモノ炭素数12~22の脂肪酸エステル、モノ炭素数12~22のアルキルグリセリルエーテル、ソルビタンモノ炭素数12~22の脂肪酸エステルから選ばれる1種又は2種以上の化合物を、好ましくは0.2重量%以上であり、より好ましくは0.4重量%以上、更に好ましくは0.7重量%以上、好ましくは15重量%以下であり、より好ましくは12重量%以下、更に好ましくは5重量%以下、
(D)水
を含有し、
成分(A)、(B)、(C)において、
(1)A/(B+C)の重量比が、0.04以上であり、好ましくは0.5以下、より好ましくは0.33以下、
(2)B/(B+C)のモル分率が0.02以上であり、好ましくは0.4以下、より好ましくは0.35以下、
(3)B+C構成成分中の1化合物単成分の占める最大モル分率が0.2以上であり、好ましくは0.75以下、より好ましくは0.7以下である乳化化粧料組成物である[1]記載の乳化化粧料組成物。
(A)N-炭素数12~22のアシルグルタミン酸又はその塩から選ばれる1種又は2種以上の化合物を0.2重量%以上3重量%以下
(B)ジステアリン酸ソルビタンから選ばれる1種又は2種以上の化合物を0.1重量%以上3.2重量%以下、
(C)炭素数12~22のアルコール、モノグリセリンモノ炭素数12~22の脂肪酸エステルから選ばれる1種又は2種以上の化合物を0.7重量%以上5重量%以下、
(D)水
を含有し、
成分(A)、(B)、(C)において、
(1)A/(B+C)の重量比が、0.04以上0.33以下、
(2)B/(B+C)のモル分率が、0.02以上0.35以下、
(3)B+C構成成分中の1化合物の占める最大モル分率が0.2以上0.7以下
である乳化化粧料組成物。
表2~表4に示す組成の乳化化粧料組成物を製造し、X線による構造解折、X線による乾燥皮膜の構造解折、保存安定性、しっとり感の持続性、保護感を評価した。結果を表2~表4に併せて示す。
なお、本発明の実施例及び比較例において、成分(B)中の各化合物の臨界充填パラメータ(CPP)及び分子量は下記の表1のとおりである。
第I相の成分を、80~95℃で加熱混合し、これに、プロペラ撹拌下(300rpm)、80~95℃に加熱した第II相を加えて乳化し、25℃まで徐々に冷却して、乳化化粧料組成物を得た。
(1)X線による構造解折、及びX線による乾燥皮膜の構造解折:
各乳化化粧料組成物について、製造直後及び保存加速試験(-15℃~60℃のサイクル/1日、これを7日間行う)後において、2θ=10~30°の広角X線回折ピークより、WilsonとOttの方法(Wilson,D.A. and Ott,E., J.Chem.Phys., 2, 231-238(1934))に従い、結晶構造を決定した。α型構造は六方晶系のことであり、親油基が親水基層の面に対して直角に配向しており、Bragg角21~23°付近に鋭い一本の回折ピークが現れるのが特徴である。
製造直後検出したのが、下記実施例及び比較例における「X線による構造解折」の結果であり、なお、保存加速試験後検出したのが、「X線による乾燥皮膜の構造解折」の結果である。
50℃および-5℃で1ヶ月保存後の組成物の状態を、目視により、下記の基準によって評価した。
◎:変化無し。
○:外観、性状が僅かに変化(色の変化、減粘又は増粘等の変化。なお、商品に影響しない範囲)。
△:外観、性状が変化(色の変化、減粘又は増粘)。
×:外観、性状が大きく変化(分離又はゲル状など)。
10名の専門パネラーが、各乳化化粧料組成物を使用したときのしっとり感の持続性について官能評価し、次の基準により判定した。
◎:7名以上が良好(良い)と評価した。
○:5~6名が良好(良い)と評価した。
△:3~4名が良好(良い)と評価した。
×:2名以下が良好(良い)と評価した。
10名の専門パネラーが、各乳化化粧料組成物を使用したときの保護感(膜のようなもので、肌を均一に被覆しているような感じ)について官能評価し、次の基準により判定した。
◎:7名以上が良好(良い)と評価した。
○:5~6名が良好(良い)と評価した。
△:3~4名が良好(良い)と評価した。
×:2名以下が良好(良い)と評価した。
実施例1~26と同様にして、表5に示す組成の乳化化粧料組成物(化粧水)を製造し、X線による構造解析を行い、保存安定性、しっとり感の持続性、保護感を評価した。結果を表5に併せて示す。
実施例1~26と同様にして、表6に示す組成の乳化化粧料組成物(乳液)を製造し、X線による構造解析を行い、保存安定性、しっとり感の持続性及び保護感を評価した。結果を表6に併せて示す。
実施例1~26と同様にして、表7に示す組成の水中油型乳化化粧料組成物(ボディーローション)を製造し、X線による構造解析を行い、保存安定性、しっとり感の持続性及び保護感を評価した。結果を表7に併せて示す。
実施例1~26と同様にして、表8に示す組成の水中油型乳化化粧料組成物(クリーム)を製造し、X線による構造解析を行い、保存安定性、しっとり感の持続性及び保護感を評価した。結果を表8に併せて示す。
Claims (12)
- 次の成分(A)、(B)、(C)及び(D):
(A)スフィンゴシン、擬似型スフィンゴシン、これらの塩、イオン性界面活性剤から選ばれる1種又は2種以上の化合物 0.1重量%以上15重量%以下、
(B)モノグリセリンジ脂肪酸エステル、ソルビタンジ脂肪酸エステルから選ばれる1種又は2種以上の化合物、
(C)セラミド、炭素数12~22のアルコール、モノグリセリンモノ炭素数12~22の脂肪酸エステル、モノ炭素数12~22のアルキルグリセリルエーテル、ソルビタンモノ炭素数12~22の脂肪酸エステルから選ばれる1種又は2種以上の化合物、
(D)水
を含有し、
成分(A)、(B)、(C)において、
(1)A/(B+C)の重量比が、0.04以上1以下、
(2)B/(B+C)のモル分率が0.02以上0.45以下、
(3)B+C構成成分中の1化合物単成分の占める最大モル分率が0.2以上0.8以下
である乳化化粧料組成物。 - 成分(B)及び成分(C)の合計含有量(B)+(C)が、1重量%以上17重量%以下である請求項1に記載の乳化化粧料組成物。
- 成分(B)及び成分(C)を構成する化合物種の合計が、3種以上である請求項1又は2に記載の乳化化粧料組成物。
- 成分(B)と(C)の平均臨界充填パラメータが0.85以上1.1以下である請求項1~3のいずれか1項記載の乳化化粧料組成物。
- 成分(A)がアニオン界面活性剤である請求項1~4のいずれか1項記載の乳化化粧料組成物。
- 成分(A)が、炭素数12~22の脂肪酸塩、N-炭素数12~22のアシルグルタミン酸塩、ポリオキシエチレン炭素数12~22のアルキルエーテルリン酸塩、炭素数12~22のN‐アルキロイルメチルタウリン塩から選ばれる1種又は2種以上の化合物である請求項1~5のいずれか1項記載の乳化化粧料組成物。
- 成分(C)が、炭素数12~22のアルコール、モノグリセリンモノ炭素数12~22の脂肪酸エステルから選ばれる1種又は2種以上の化合物である請求項1~6のいずれか1項記載の乳化化粧料組成物。
- 成分(C)が、セタノール、ステアリルアルコール、グリセリンモノベヘン酸エステルから選ばれる1種又は2種以上の化合物である請求項1~7のいずれか1項記載の乳化化粧料組成物。
- 成分(B)が、モノグリセリンジ脂肪酸エステルから選ばれる1種又は2種以上の化合物である請求項1~8のいずれか1項記載の乳化化粧料組成物。
- 成分(A)の含有量が、好ましくは0.1重量%以上であり、より好ましくは0.2重量%以上、更に好ましくは0.5重量%以上、好ましくは、15重量%以下であり、より好ましくは5重量%以下、更に好ましくは3重量%以下であり、
成分(B)の含有量が、好ましくは、0.1重量%以上であり、より好ましくは0.5重量%以上、更に好ましくは1重量%以上、好ましくは14.8重量%以下であり、より好ましくは5重量%以下、更に好ましくは3.2重量%以下であり、
成分(C)の含有量が、好ましくは0.2重量%以上であり、より好ましくは0.4重量%以上、更に好ましくは0.7重量%以上、好ましくは15重量%以下であり、より好ましくは12重量%以下、更に好ましくは5重量%以下である、
請求項1~9のいずれか1項記載の乳化化粧料組成物。 - 請求項1~10のいずれか1項記載の乳化化粧料組成物を皮膚に塗布し、乾燥させ、α‐ゲル構造を有する皮膜を形成する皮膚保湿のための使用。
- 請求項1~10のいずれか1項記載の乳化化粧料組成物を皮膚に塗布し、乾燥させ、α‐ゲル構造を有する皮膜を形成し、皮膚を保湿する方法。
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