WO2013024815A3 - ブロック共重合体、および抗血栓コーティング剤 - Google Patents

ブロック共重合体、および抗血栓コーティング剤 Download PDF

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Publication number
WO2013024815A3
WO2013024815A3 PCT/JP2012/070487 JP2012070487W WO2013024815A3 WO 2013024815 A3 WO2013024815 A3 WO 2013024815A3 JP 2012070487 W JP2012070487 W JP 2012070487W WO 2013024815 A3 WO2013024815 A3 WO 2013024815A3
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WIPO (PCT)
Prior art keywords
block copolymer
coating agent
antithrombotic coating
antithrombotic
provision
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PCT/JP2012/070487
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English (en)
French (fr)
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WO2013024815A2 (ja
Inventor
原口　和敏
和臣 久保田
武久　敢
高田　哲生
典子 山東
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一般財団法人川村理化学研究所
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Application filed by 一般財団法人川村理化学研究所 filed Critical 一般財団法人川村理化学研究所
Priority to EP12823466.3A priority Critical patent/EP2746308B1/en
Priority to CN201280039648.9A priority patent/CN103781812B/zh
Priority to US14/237,664 priority patent/US9474835B2/en
Publication of WO2013024815A2 publication Critical patent/WO2013024815A2/ja
Publication of WO2013024815A3 publication Critical patent/WO2013024815A3/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
    • C09D133/24—Homopolymers or copolymers of amides or imides
    • C09D133/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D153/00—Coating compositions based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Coating compositions based on derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2438/00—Living radical polymerisation
    • C08F2438/03—Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Graft Or Block Polymers (AREA)
  • Materials For Medical Uses (AREA)
  • Paints Or Removers (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • External Artificial Organs (AREA)
  • Prostheses (AREA)

Abstract

　本発明では、膜形成能に優れ、且つ基材との接着性にも優れ、且つタンパク質を吸着しない性質を持つ共重合体、特にブロック共重合体を提供することにある。また、従来の抗血栓コーティング剤と比べて、抗血栓性および基材への接着性の両方に優れた特性を示す抗血栓コーティング剤、及びそれらをコーティングして得られる医療用具を提供することである。　（メタ）アクリル酸エステル系モノマー（ａ）の重合体（Ａ）と（メタ）アクリルアミド系モノマーの重合体（Ｂ）からなるブロック共重合体が、皮膜形成能に優れ、且つ基材との接着性が良好であり、該ブロック共重合体の提供により、上記課題を解決する。
PCT/JP2012/070487 2011-08-15 2012-08-10 ブロック共重合体、および抗血栓コーティング剤 WO2013024815A2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP12823466.3A EP2746308B1 (en) 2011-08-15 2012-08-10 Use of block copolymer and antithrombotic coating agent
CN201280039648.9A CN103781812B (zh) 2011-08-15 2012-08-10 嵌段共聚物的涂膜、以及抗血栓涂层剂
US14/237,664 US9474835B2 (en) 2011-08-15 2012-08-10 Block copolymer and antithrombotic coating agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011-177589 2011-08-15
JP2011177589 2011-08-15

Publications (2)

Publication Number Publication Date
WO2013024815A2 WO2013024815A2 (ja) 2013-02-21
WO2013024815A3 true WO2013024815A3 (ja) 2013-03-28

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US (1) US9474835B2 (ja)
EP (1) EP2746308B1 (ja)
JP (2) JP5439551B2 (ja)
CN (1) CN103781812B (ja)
WO (1) WO2013024815A2 (ja)

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JP5439551B2 (ja) 2011-08-15 2014-03-12 一般財団法人川村理化学研究所 ブロック共重合体の塗膜
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JP6278731B2 (ja) * 2014-02-24 2018-02-14 テルモ株式会社 抗血栓性医療材料、および該医療材料を利用した医療用具
WO2016133189A1 (ja) * 2015-02-20 2016-08-25 日産化学工業株式会社 生体適合性塗布膜形成用組成物
US10188774B2 (en) * 2015-03-10 2019-01-29 Terumo Kabushiki Kaisha Method for producing antithrombotic coating material
WO2016143787A1 (ja) * 2015-03-10 2016-09-15 国立大学法人山形大学 抗血栓性ブロック共重合体
JP2016193147A (ja) * 2015-04-01 2016-11-17 株式会社パイオラックスメディカルデバイス ステントの製造方法及び該製造方法によって得られるステント
JP2016198426A (ja) * 2015-04-14 2016-12-01 Dic株式会社 抗炎症性コーティング剤およびこれを用いた抗炎症性材料および医療用具
JP6597280B2 (ja) * 2015-12-21 2019-10-30 日立化成株式会社 ダイボンディングフィルム
WO2017155019A1 (ja) * 2016-03-10 2017-09-14 国立大学法人山形大学 蛋白質吸着抑制剤および蛋白質吸着抑制の方法
WO2017217363A1 (ja) * 2016-06-13 2017-12-21 東亞合成株式会社 モールディング樹脂組成物及び成形品
JP2018012811A (ja) * 2016-07-22 2018-01-25 東ソー株式会社 ブロック共重合体
JP6813996B2 (ja) * 2016-08-31 2021-01-13 大塚化学株式会社 ブロック共重合体、および、これを含有する樹脂改質剤、エポキシ樹脂組成物
WO2018116904A1 (ja) 2016-12-22 2018-06-28 Dic株式会社 細胞培養基材
US11427803B2 (en) 2016-12-22 2022-08-30 Fujifilm Corporation Cell culture substrate
KR102373743B1 (ko) 2017-06-26 2022-03-11 마루젠 세끼유가가꾸 가부시키가이샤 단백질 흡착 방지제, 단백질 흡착 방지막 및 이것을 이용하는 의료용구
JP7142541B2 (ja) * 2017-11-29 2022-09-27 大塚化学株式会社 ブロック共重合体を含有する重合生成物の製造方法
WO2020149385A1 (ja) * 2019-01-16 2020-07-23 積水フーラー株式会社 架橋性ブロック共重合体及びコーティング剤
WO2022030440A1 (ja) * 2020-08-07 2022-02-10 東亞合成株式会社 ビニル系重合体及びその製造方法
CN113150225B (zh) * 2021-05-11 2022-01-04 西南石油大学 双功能配体、3d聚合物分子刷及其制备方法

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Also Published As

Publication number Publication date
CN103781812B (zh) 2016-08-17
EP2746308B1 (en) 2016-11-30
JP2013056146A (ja) 2013-03-28
JP5439551B2 (ja) 2014-03-12
CN103781812A (zh) 2014-05-07
US9474835B2 (en) 2016-10-25
EP2746308A2 (en) 2014-06-25
EP2746308A4 (en) 2015-03-11
JP5492952B2 (ja) 2014-05-14
WO2013024815A2 (ja) 2013-02-21
JP2013057058A (ja) 2013-03-28
US20140235748A1 (en) 2014-08-21

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