WO2012104584A1 - Silicone wound dressing laminate and method for making the same - Google Patents

Silicone wound dressing laminate and method for making the same Download PDF

Info

Publication number
WO2012104584A1
WO2012104584A1 PCT/GB2012/000099 GB2012000099W WO2012104584A1 WO 2012104584 A1 WO2012104584 A1 WO 2012104584A1 GB 2012000099 W GB2012000099 W GB 2012000099W WO 2012104584 A1 WO2012104584 A1 WO 2012104584A1
Authority
WO
WIPO (PCT)
Prior art keywords
layer
silicone
base layer
substrate
wound dressing
Prior art date
Application number
PCT/GB2012/000099
Other languages
English (en)
French (fr)
Inventor
Deborah Addison
Sally Stephens
Patrick Joseph BROSNAN
Original Assignee
Systagenix Wound Management Ip Co. B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Systagenix Wound Management Ip Co. B.V. filed Critical Systagenix Wound Management Ip Co. B.V.
Priority to EP12705381.7A priority Critical patent/EP2670369B1/de
Priority to US13/982,650 priority patent/US10568767B2/en
Publication of WO2012104584A1 publication Critical patent/WO2012104584A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
    • A61F13/01029—Non-adhesive bandages or dressings characterised by the structure of the dressing made of multiple layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A61F13/0213—Adhesive bandages or dressings with fluid retention members the fluid retention member being a layer of hydrocolloid, gel forming material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A61F13/0223—Adhesive bandages or dressings with fluid retention members characterized by parametric properties of the fluid retention layer, e.g. absorbency, wicking capacity, liquid distribution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A61F13/0226—Adhesive bandages or dressings with fluid retention members characterised by the support layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00217—Wound bandages not adhering to the wound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00655—Plasters adhesive
    • A61F2013/00659—Plasters adhesive polymeric base

Definitions

  • the present invention relates to wound dressings comprising a laminate of a base layer and a silicone-coated layer, wherein the silicone-coated layer is bonded to the base layer.
  • the invention also relates to methods of making such laminates.
  • Dressing materials for application to the surface of wounds should desirably be nonadherent to the moist wound surface.
  • a soft non-adherent or tacky (i.e. weakly adhesive) hydrophobic material is suitable for the wound contacting surface of the material.
  • the wound contacting material should desirably be liquid-permeable to allow passage of wound fluid, especially for heavily exuding wounds such as burns.
  • the material should also be non-irritating, inexpensive, and stable to common sterilization methods such as ionizing radiation.
  • Traditional "tulle gras" dressings generally consist of a layer of gauze coated with paraffin wax. Such dressings have a number of desirable properties, and for this reason have been used extensively for many years.
  • tulle gras dressings applied to a wound will usually remain in place simply by adhesion of the paraffin wax to the patient's skin (or to itself in the case of a dressing wrapped around a finger, for example) while a securing bandage is applied.
  • Tulle gras dressings are also quite inexpensive.
  • tulle gras dressings do have a number of disadvantages. Principal amongst these is that, although initially non-adherent, they often become "dry" (in the sense of losing their paraffin coating) and consequently adhere to the wound to which they are applied.
  • EP-A-0251810 describes wound dressing s that overcome the above disadvantages by replacing the paraffin wax coating of conventional tulle gras by a tacky or non-tacky, hydrophobic silicone coating on a gauze or mesh substrate.
  • the gauze may be provided with a tacky silicone coating on one side and a non-tacky silicone coating having a different composition on the other side. Similar materials are described in WOA-8705206.
  • EP-A-0342950 describes similar wound dressings having a non-adherent silicone coating. The adherence of the silicone is reduced by addition of an amine-extended polyurethane.
  • WO-A-9319710 describes similar dressings further comprising a region of absorbent material laminated to the silicone-coated apertured substrate, and a fluid barrier layer behind the absorbent layer.
  • the above silicone-coated gauze dressings have achieved widespread use. However, a difficulty with the silicone-coated gauzes is that it can be difficult to laminate them securely to further dressing layers, such as a microorganism-impermeable semipermeable backing sheet or an absorbent layer. This is because the hydrophobic silicone is by its nature completely or substantially non-adherent. It would be desirable to make wound dressings having a laminated structure in which the apertured, silicone- coated wound contacting layer is securely bonded to one or more further layers, such as absorbent layers or continuous backing film layers.
  • WO-A-20100056544 describes gentle-to-skin silicone gel adhesives prepared by crosslinking a silicone prepolymer with electron beam or gamma radiation.
  • the adhesives may be applied to suitable substrates before crosslinking.
  • the present inventors have found that normally non-adherent silicone-coated substrates can be strongly bonded to further wound dressing layers, such as absorbent layers or backing sheets, without the use of adhesives or silicone primer layers. This bonding is achieved by applying a silicone-coated layer wherein the silicone is incompletely cured to the further layer, followed by final curing of the silicone with ionizing radiation.
  • the resulting laminates are useful as or in wound dressings.
  • the present invention provides a wound dressing comprising: a base layer and an apertured layer laminated to the base layer, said apertured layer comprising an apertured substrate and a silicone coating layer on said substrate, wherein the apertured layer has been bonded to the base layer by ionizing radiation-induced bonding of the silicone coating to said base layer.
  • the present invention provides a wound dressing comprising: a base layer and an apertured layer laminated to the base layer, said apertured layer comprising an apertured substrate and a silicone coating layer on said substrate, wherein the silicone coating is directly covalently bonded to the base layer.
  • the present invention provides a wound dressing comprising: a base layer and an apertured layer laminated to the base layer, said apertured layer comprising an apertured substrate and a silicone coating layer on said substrate, wherein the apertured layer is directly bonded to the base layer and the peel strength required to separate the apertured layer from the base layer is greater than about 200mN/cm, preferably greater than about 300mN/cm, for example from about 400 m /cm to about lOOO mN/cm.
  • the invention provides a method of making a wound dressing comprising the steps of: providing an apertured substrate layer; coating the substrate layer with a fluid silicone prepolymer composition; thermally partially curing said silicone prepolymer composition to form a partially cured silicone coating on the substrate; laminating the coated substrate layer to a base layer to form a laminate having said partially cured silicone coating in contact with a surface of the base layer; followed by exposing the laminate to ionizing radiation, to further cure the partially cured silicone coating and to bond the silicone coating to said surface of the base layer. It appears that the final cure with ionizing radiation results in chemical (e.g.
  • wound dressing refers primarily to products for topical application to wounds. However, it may encompass products for application to internal wounds. The products of the present invention may also be useful for application to intact skin, for example for transdermal administration of medicaments.
  • the base layer suitably provides a protective covering, cusWoning, mechanical support and/or liquid absorbency to the wound dressing.
  • the base layer is formed from a material that is hydrophilic, suitably a material that does not swell or dissolve significantly in water or wound fluid.
  • the base layer is in the form of a sheet, for example a sheet having an uncompressed thickness of from about 0.2mm to about 15mm, for example from about 0.5 mm to about 5mm.
  • the base layer may be any of the layers conventionally used to form layers over a wound contacting layer in a laminated wound dressing, for example absorbent layers or backing layers.
  • the base layer is a backing layer in the form of a sheet of continous semipermeable or impermeable polymer.
  • the base layer may be an absorbent layer for example a hydrophilic foam, a sponge, a film, or a textile layer.
  • the textile may be nonwoven, knitted or woven.
  • the base layer may be a layer of pressure-sensitive adhesive, for example a layer of adhesive coated on a backing sheet. In these embodiments, the bonding between the silicone coating and the adhesive layer is stronger than would be expected simply from the effect of the adhesive, as will be explained further below.
  • the present invention achieves strong bonding between the silicone coating and base layer surfaces that are normally incompatible with and non-adherent to silicone, including hydrophilic surfaces such as polyurethane or hydrocolloid surfaces. This bonding is achieved without the use of a silicone primer to improve adhesion, i.e. it is direct bonding between the silicone and the material of the base layer.
  • the base layer is (a) a semipermeable or impermeable polymer film, or (b) a hydrophilic foam sheet, or (c) a nonwoven web.
  • Suitable semipermeable or impermeable polymer films for the base layer include any of the semipermeable films conventionally used to form a backing sheet of wound dressings.
  • the films are suitably continuous, i.e. they do not comprise macroscopic apertures that would allow passage of wound fluid.
  • the base layer in these embodiments is also microorganism-impermeable.
  • Suitable continuous conformable base layers of this type will suitably have a moisture vapor transmission rate (MVTR) of the base layer alone of 300 to 5000 g/m 2 /24hrs, suitably 500 to 2000 g/m 2 /24hrs at 37.5 °C at 100% to 10% relative humidity difference. It has been found that such moisture vapor transmission rates allow the wound under the dressing to heal under moist conditions without causing the skin surrounding the wound to macerate.
  • the base layer thickness in these embodiments is suitably in the range of 10 to 1000 micrometers, more suitably 100 to 500 micrometers.
  • Suitable polymers for forming the base layer in these embodiments include polyurethanes and poly alkoxyalkyl acrylates and methacrylates.
  • the base layer in these embodiments comprises a continuous layer of a high density blocked polyurethane foam that is predominantly closed-cell.
  • a suitable backing sheet material is the polyurethane film available under the Registered Trade Mark ESTANE 5714F. Also suitable are elastomeric polymeric esters such as Du Pont HYTREL (Registered Trade Mark).
  • Suitable hydrophilic foam sheets for use as the base layer include polyurethane foams. carboxylated butadiene-styrene rubber, polyacrylate, polyvinylic or cellulosic foams.
  • the hydrophilic foam may be open-cell or closed-cell.
  • the foam comprises a polyurethane, and more suitably it comprises at least 50% by weight of one or more polyurethanes, for example at least 75% by weight thereof.
  • the hydrophilic polyurethane foam materials are formed by reacting particular diisocyanates or isocyanate-capped prepolymers with suitable chain extending compounds having amine and/or alcohol multiple functionality. Chain terminating compounds such as mono-amines or monohydric alcohols may be included in the reaction mixture. Water may be included in the reaction mixture, since it reacts with isocyanate to liberate carbon dioxide for foaming the mixture.
  • the hydrophilic foams used in the base layers of the invention may also have the property of swelling and expanding when water is absorbed.
  • the degree of swelling of the hydrophilic foams on complete saturation with an aqueous medium is typically at least 100% (expressed in terms of increase in volume), and suitably at least 200%.
  • Preferred foams swell by 400 to 800%. Despite this high degree of swelling, however, the foams of the invention retain their integrity even after absorption of large quantities of water.
  • T)'pically, the cells of the hydrophilic foams have an average diameter in the range 0.1 to 0.6 mm.
  • Suitably hydrophilic foams are as described in EP-A-0541391. These foam layers are available from Systagenix Wound Management under the Registered Trade Marks TELLE and HYPOL.
  • the basis weight of the hydrophilic foam when used as a base layer in the materials of the present invention is from 0.2 to 1.5 kg/m , more suitably 0.5 to 1.0 kg/m 2 .
  • Suitable textiles for use as the base layer include any of those conventionally used for absorbent products, including cellulose woven or nonwoven webs, or cellulose derivatives such as viscose, rayon or oxidized regenerated cellulose.
  • the fabric comprises at least about 10wt.% of hydrogel-forming absorbent fibers based on the dry weight of the fabric, for example, the fabric comprises at least about 20wt.% of the hydrogel-forming fibers, for example from about 30wt.% to about 50wt.% of such fibers.
  • hydrogel-forming fibers refers to fibers that can absorb at least about twice their own weight of water, suitably at least about four times their own weight of water, to form a hydrogel.
  • the fibers are normally insoluble in water.
  • Suitable materials for the hydrogel-forming fibers include alginates, carboxymethylcelluloses, hydroxyethyl- celluloses, polyacrylates, and hyaluronates. Suitable materials are calcium alginate and sodium carboxymethylcellulose and mixtures thereof.
  • the fabric comprises at least about 10wt.% based on the dry weight of the fabric of substantially non-water-absorbent textile fibers, and suitably it comprises at least about 20wt.% of such fibers, for example from about 30wt.% to about 60wt.% of such fibers.
  • Suitable non-absorbent textile fibers include polyamide fibers such as nylon fibers, polyolefin fibers, and viscose fibers.
  • the absorbent layer is similar to those described in WO03/053584.
  • the absorbent layer comprises or consists essentially of a nonwoven fabric made up of a mixture of from about 10wt.% to about 90wt.% of hydrogel-forming absorbent fibers and from about 90wt.% to about 1 wt.% of non-absorbent textile fibers.
  • at least some of the non-absorbent textile fibers are coated with metallic silver (Ag°) as an antimicrobial agent.
  • the amount of silver in the fabric is from about 0.1% to about lOwt.%, based on the dry weight of the fabric . Textiles of this kind are available from Systagenix Wound Management under the Registered Trade Mark SILVERCEL.
  • the basis weight of the textile base layer may be in the range of 50-500 g m , such as 100-400 g/m .
  • the uncompressed thickness of the textile layer may be in the range of from 0.5 mm to 10 mm, such as 1 mm to 4 mm.
  • the free (uncompressed) liquid absorbency measured for physiological saline may be in the range of 5 to 30 g/g at 25°C.
  • the base layer may be a layer of adhesive, in particular a pressure- sensitive adhesive.
  • the base layer adhesive may be moisture vapor transmitting and/or patterned to allow passage of water vapor therethrough.
  • the adhesive layer is suitably a continuous moisture vapor transmitting, pressure-sensitive adhesive layer of the type conventionally used for island-type wound dressings, for example, a pressure sensitive adhesive based on acrylate ester copolymers, polyvinyl ethyl ether and polyurethane as described for example in GB-A- 1280631.
  • the basis weight of the adhesive layer is suitably 20 to 250 g/m 2 , and more suitably 50 to 150 g m 2 .
  • Polyurethane-based pressure sensitive adhesives are preferred.
  • the base layer may comprise or consist of an odor absorbent textile, such as a charcoal cloth.
  • an odor absorbent textile such as a charcoal cloth.
  • GB-A-1301 101 EP-A-0053936 and GB-A-2127389 describe activated carbon cloth for use as an odor absorbent wound dressing, for example in the treatment of heavily infected wounds, varicose ulcers and fungating carcinomas.
  • the cloth is produced by carbonising a cellulosic cloth, such as a suitably treated woven viscose rayon cloth.
  • the activated carbon cloth is relatively friable, and tends to shed particles of carbon in use.
  • the silicone coated substrate may be bonded directly to the charcoal cloth, or it may be bonded to a scrim enclosing the charcoal cloth.
  • the base layer may comprise or consist of a second layer of the silicone coated apertured layer, which may be the same or different from the first layer of silicone coated apertured material.
  • the methods of the present invention can achieve strong bonding between layers of apertured, silicone- coated materials.
  • These embodiments allow the formation of envelopes of the silicone- coated substrate material having edges bonded together in face-to-face relation.
  • the envelopes can contain any of the wound dressing materials described above, in sheet or particulate form.
  • the silicone coated substrate is apertured, whereby the substrate is permeable to wound fluid.
  • the substrate may be a mesh or web or fabric suitably formed from a woven, nonwoven or knitted textile, or it may be a molded mesh.
  • the substrate is a fabric such as a gauze, or a mesh, having an array of apertures.
  • the size and shape of the apertures in the substrate are not critical, but the apertures should suitably be such as to ensure that the material can be adequately coated with silicone gel without them becoming occluded.
  • the apertures generally have an aspect ratio of from 1:1 to 5:1, and preferably from 1:1 to 2:1.
  • the apertures may be approximately circular or approximately square.
  • the apertures suitably have an average diameter of from 0.3 to 4 mm, and more suitably from 0.5 to 2 mm.
  • the substrate is suitably formed from any medically acceptable material, such as cellulose, polyolefins, polyesters, or polyamides.
  • An especially suitable material is cellulose acetate gauze.
  • Substrates having a weight of from 15 to 200 g/m 2 are generally found to be suitable for use in the products of the invention, and fabrics weighing from 50 to 150 g/m 2 are most suitable.
  • certain embodiments employ a fabric of from 80 to 120 g/m 2 .
  • the silicone-coated substrate product retains open apertures to allow passage of wound fluid through the coated substrate.
  • an array of apertures may extend through said silicone coatings and the substrate layer.
  • the open area of the coated substrate in the final product may for example be from about 1% to about 70%, for example from about 10% to about 50%.
  • the substrate is coated on both sides with the silicone coating, so that the face of the substrate opposite the base layer presents a silicone surface to the wound.
  • the wound facing silicone surface may be non-adherent, or it may be tacky.
  • the tackiness of the wound facing surface as measured by a loop tack test is suitably from about 0.4N to about 2N, more suitably from about 0.5N to about 1.5N.
  • the total coating weight of the silicone on the substrate is suitably from about 50 g/m 2 to about 500 g/m 2 , for example from about 80 g/m 2 to about 200 g/m 2 , typically from about 100 g/m 2 to about 150 g/m 2 .
  • the silicone is suitably a soft skin adhesive silicone composition. Suitable chemistry is described below.
  • the silicone is suitably hydrophobic.
  • the substrate may be printed or dyed with decorative or informative matter with little danger of the ink or dye being released into the wound to which the dressing is applied.
  • Visible indicia such a colour or writing, may be provided on the substrate.
  • the coated substrate is laminated to the base layer, and optionally to further layers, to form the wound dressings according to the invention.
  • Some of the laminate structures falling within the scope of the invention are as follows:
  • Embodiment 1 An absorbent base layer in the form of a sheet of absorbent material (or adsorbent material, such as charcoal cloth) having upper and lower surfaces, and having the silicone-coated substrate bonded to at least one of the surfaces to provide a nonadherent wound-contacting surface.
  • silicone-coated substrates are bonded to both surfaces to provide a dressing material that can be applied to the wound in either orientation.
  • Embodiment 2 a laminate according to Embodiment 1, further laminated to an adhesive-coated backing sheet to provide an absorbent dressing with a liquid- impermeable backing sheet.
  • the laminate is formed so that at least the wound facing surface of the absorbent layer opposite to the backing sheet is bonded to the silicone-coated substrate to provide a non-adherent wound contacting surface. Further layers, such as further absorbent layers, may be provided between the absorbent layer and the backing sheet.
  • Embodiment 3 Similar to Embodiment 2, but in the form of an island dressing such that the adhesive-coated backing sheet is larger than the absorbent layer whereby a margin of the backing sheet extends around the edges of the absorbent layer.
  • the silicone-coated substrate may be coterminous with the absorbent island, or it may extend beyond the edges of the island whereby a margin of the silicone- coated substrate is bonded to the backing sheet or to the adhesive coating on the backing sheet around the absorbent island.
  • Embodiment 4 This embodiment has the silicone-coated substrate directly bonded to a liquid-impermeable backing sheet, or to a layer of adhesive on the backing sheet, i.e. there is no absorbent layer. These embodiments are suitable for more lightly exuding wounds for which water vapour permeability through the semipermeable backing sheet is sufficient.
  • Embodiment 5 This embodiment has the silicone-coated substrate directly bonded to a liquid-impermeable backing sheet, or to a layer of adhesive on the backing sheet, and further comprising an absorbent layer or absorbent island over the silicone-coated substrate, i.e. the substrate is sandwiched between the absorbent layer and the base layer.
  • the substrate may extend to the edges of the backing sheet to provide a more skin-friendly surface to the margin of the dressing.
  • a further layer of the silicone-coated substrate may be bonded to the wound facing surface of the absorbent layer or island.
  • Embodiment 6 Two pieces (or one folded piece) of silicone coated substrate encasing an absorbent or adsorbent layer such as charcoal cloth.
  • the silicone coated substrate is larger than the absorbent /adsorbent layer whereby the substrate overlaps around the edges of the absorbent/adsorbent layer to form margins which are bonded together in face-to-face fashion to form an envelope of the silicone-coated substrate around the absorbent /adsorbent layer.
  • the wound dressing according to the present invention comprises less than 10% water prior to use as an absorbent, more suitably less than 5% water and more suitably it contains less than 2% of water before use.
  • the wound dressing according to the present invention has a maximum total uncompressed thickness of from about 0.2mm to about 15mm, for example from about 0.5 mm to about 5mm.
  • the wound dressing according to the present invention is in the form of a piece having a total area of from about 1cm 2 to about 1000cm 2 , for example from about 5cm to about 400cm .
  • the dressing may comprise one or more releasable cover sheets over the wound facing surface of the substrate opposite to the base layer to protect the substrate surface before use.
  • the cover sheets may comprise a film of polyethylene, polypropylene or fluorocarbons and papers coated with these materials.
  • the cover sheet is a release-coated paper sheet, such as a silicone release-coated paper sheet.
  • silicone-coated release papers are POLYSLIK (Registered Trade Mark) supplied by H.P. Smith & Co., offered in various formulations to control the degree of adhesion of the paper to the silicone coated substrate surface.
  • the cover sheets may comprise two or more parts, such as a first removable part having a first edge and a second removable part that meets the first part along the first edge.
  • a first removable part having a first edge and a second removable part that meets the first part along the first edge.
  • one of the parts is folded back to provide a folded-back margin, and the other part overlaps the said folded-back margin. This provides an easy-to-grasp margin on each part in the region of overlap to assist removal of the cover sheet by the care giver.
  • the cover sheets may comprise three parts, for example as described in detail in EP-A- 0117632.
  • the wound dressings of the invention are sterile and packaged in a microorganism-impermeable container.
  • the invention provides a method of making a wound dressing comprising the steps of: providing an apertured substrate layer; coating the substrate layer with a fluid silicone prepolymer composition; thermally partially curing said silicone prepolymer composition to form a partially cured silicone coating on the substrate; laminating the coated substrate layer to a base layer to form a laminate having said partially cured silicone coating in contact with a surface of the base layer; followed by exposing the laminate to ionizing radiation, to further cure the partially cured silicone coating and to bond the silicone coating to said surface of the base layer.
  • the substrate layer is suitably as previously described for the products of the invention.
  • the substrate layer is permeable to the fluid silicone prepolymer composition.
  • the step of coating may be performed in any conventional way, for example immersion, spraying, or doctor blade.
  • the step of coating suitably comprises passing the coated substrate through nip rollers to ensure smooth coating and penetration of the coating composition.
  • the step of coating is followed by a step of blowing gas (such as air) through the substrate to ensure that the apertures in the material are open after coating.
  • the fluid silicone coating composition is suitably substantially or completely solvent-free.
  • the methods of the present invention allow substrates having silicone coating on the upper and lower surfaces to be made with a single silicone coating composition on both surfaces.
  • the silicone composition is a so-called soft skin adhesive silicone elastomer.
  • silicones can be made by an addition reaction (hydrosilylation) between (a) a vinyl functional polydimethyl siloxane, such as bis-dimethyl vinyl PDMS, and (b) a hydrogen functional siloxane, such as dimethyl, methylhydrogen siloxane copolymers, hydrogen dimethylsiloxy terminated PDMS.
  • the cure reaction is catalyzed by a hydrosilylation catalyst, such as a noble metal catalyst, suitably a platinum catalyst.
  • the silicone prepolymer composition further comprises a polymerization inhibitor that is evaporated from said composition during said step of thermally partially curing, for example 2-methyl-3-butyn-2-ol.
  • the polymerization inhibitor is suitably present in an amount of from about 0.001wt.% to about lwt.%, for example from about 0.01wt.% to about 0. lwt.% before curing.
  • Silicone skin adhesive compositions are suitably supplied as two-part systems: Part A contains at least the vinyl prepolymer and the catalyst, while Part B contains the vinyl prepolymer and the SiH siloxane cross linker. The components are mixed immediately before use, optionally with addition of the polymerization inhibitor.
  • the silicone coating composition comprises or consists essentially of the following components:
  • (C) optionally a platinum group metal catalyst suitably in a quantity providing 0.1 to 500 weight parts as platinum group metal per 1,000,000 weight parts component (A);
  • a volatile polymerization inhibitor suitably selected from: alkyne alcohols such as 2-methyl-3-butyn-2-ol, 3,5-dimethyl-l-hexyn-3-ol, and phenylbutynol; ene-yne compounds such as 3-methyl-3-penten-l-yne and 3,5-dimethyl-3- hexen-l-yne; tetramethyltetrahexenyl-cyclotetrasiloxane; and benzotriazole.
  • alkyne alcohols such as 2-methyl-3-butyn-2-ol, 3,5-dimethyl-l-hexyn-3-ol, and phenylbutynol
  • ene-yne compounds such as 3-methyl-3-penten-l-yne and 3,5-dimethyl-3- hexen-l-yne
  • tetramethyltetrahexenyl-cyclotetrasiloxane and benzotriazole
  • the diorganopolysiloxane, component (A), used in the instant invention is the base component of the total composition.
  • This diorganopolysiloxane must contain at least 2 alkenyl groups in each molecule in order for this composition to cure into a rubbery elastic silicone rubber coating composition.
  • the diorganopolysiloxane (A) comprises essentially straight-chain organopolysiloxane with the average unit formula RnSiO(4 -n )/2, wherein is selected from substituted and unsubstituted monovalent hydrocarbon groups and n has a value of 1.9 to 2.1.
  • R may be exemplified by alkyl groups such as methyl, ethyl, propyl, and others; alkenyl groups such as vinyl, allyl, and others; aryl groups such as phenyl, and others; and haloalkyl groups such as 3,3,3-trifluoropropyl and others.
  • the diorganopolysiloxane (A) should have a viscosity at 25° C of at least 100 centipoise (1 d Pa.s).
  • the viscosity of diorganopolysiloxane (A) at 25° C is preferably from 1,000 centipoise (1 Pa.s) to 100,000 centipoise (100 Pa.s).
  • the diorganopolysiloxane (A) may be exemplified by dimethylvinylsiloxy-endblocked dimethylpolysiloxanes, dimethylvinylsiloxy-endblocked dimethylsiloxane-methylvinylsiloxane copolymers, and dimethylvinyl-siloxy-endblocked dimethylsiloxane-methylphenylsiloxane copolymers.
  • Component (B) an organopolysiloxane that contains at least 2 silicon-bonded hydrogen atoms in each molecule, is a crosslinker for the composition of the instant invention.
  • the organopolysiloxane (B) may be exemplified by trimethylsiloxy-endblocked methyl- hydrogenpolysiloxanes, trimethylsiloxy-endblocked dimethylsiloxanemethylhydrogen- siloxane copolymers, dimethylphenylsiloxy-endblocked methylphenylsiloxanemethyl- hydrogensiloxane copolymers, cyclic methylhydrogenpolysiloxanes, and copolymers that contain the dimethylhydrogensiloxy unit and Si04/2 unit.
  • the organohydrogenpolysiloxane (B) should be added in a quantity that the ratio between the number of moles of silicon-bonded hydrogen atoms in this organohydrogenpolysiloxane and the number of moles of alkenyl groups in component (A) has a value of 0.6:1 to 20:1.
  • the platinum group metal catalyst, component (C), used in the compositions is a curing catalyst.
  • the platinum group metal catalyst (C) may be exemplified by platinum micropowder, platinum black, chloroplatinic acid, platinum tetrachloride, olefin complexes of chloroplatinic acid, alcohol solutions of chloroplatinic acid, complexes between chloroplatinic acid and alkenylsiloxanes, rhodium compounds, and palladium compounds.
  • the platinum group metal catalyst (C) should be added generally at 0.1 to 500 weight parts as platinum group metal per 1 ,000,000 weight parts component (A), and is preferably used at 1 to 50 weight parts as platinum group metal per 1,000,000 weight parts component (A). The reaction will not develop adequately at less than 0.1 weight parts, while additions in excess of 500 weight parts are uneconomical.
  • the coated substrate is then subjected to thermal curing to partially cure the silicone.
  • the thermal coating is suitably performed continuously by passing the coated substrate through an oven. Suitable thermal curing conditions include exposure to a temperature of from about 80°C to about 200°C, for example about 120°C to about 180°C for a time of from about 1 minute to about 10 minutes, for example about 1.5 minutes to about 5 minutes.
  • the elevated temperature results in evaporation of the polymerization inhibitor from the silicone composition and therefore in polymerization of the silicone.
  • the resulting material is chemically polymerized, but capable of further curing by ionizing radiation as explained further below.
  • the partially thermally cured material is dimensionally stable, for example an elastomer or a gel, so that it can readily be laminated onto the base layer without substantial deformation.
  • the siliconized substrate is suitably laminated to the base layer after the step of thermal polymerizing since the silicone is no longer fluid at this stage so that handling is easier and the porosity of the substrate is preserved in the laminating step.
  • the siliconized substrate is only weakly adhered to the base layer at this stage.
  • the releasable cover sheet is applied over the surface of the substrate opposite the base layer also at this stage.
  • the releasable cover sheet is applied after the step of curing with ionizing radiation described below.
  • the partially cured material is then subjected to a final cure with ionizing radiation.
  • the ionizing radiation is suitably selected from e-beam radiation and gamma radiation.
  • E-beam and gamma ray curing are well-known. The cure depends on the specific equipment used, and those skilled in the art can define a dose calibration model for the specific equipment, geometry, and line speed, as well as other well understood process parameters.
  • a Model CB-300 electron beam generating apparatus available from Energy Sciences, Inc. (Wilmington, MA).
  • a support film e.g., polyester terephthalate support film
  • the chamber is flushed with an inert gas, e.g., nitrogen while the samples are e-beam cured. Multiple passes through the e- beam sterilizer may be needed.
  • gamma irradiation equipment includes equipment often used for gamma irradiation sterilization of products for medical applications.
  • Cobalt 60 sources are appropriate.
  • Total absorbed doses are suitably from 20 to 60 kGy, more suitably from about 35 to 50kGy and dose rates are suitably about 7 to 8 kGy/hour.
  • the step of further curing with ionizing radiation is effective to bond the silicone surface of the substrate strongly to the surface of the base layer. This is thought to be due to the ionizing radiation forming covalent bonds between the silicone and the base layer material.
  • the effect is seen also when the base layer is coated with a conventional pressure sensitive medical adhesive, such as a polyurethane-based pressure sensitive adhesive. In these cases, a bond is formed with the adhesive that has much higher peel strength than the bond formed with the adhesive before irradiation.
  • the method comprises the step of packaging the material in a microorganism- impermeable container prior to the step of further curing with ionizing radiation, whereby the step of further curing also sterilizes the material.
  • any of the products of the invention may be obtainable by a method according to the invention.
  • Any feature disclosed herein in relation to any one or more aspects of the invention is suitable for use in any of the other aspects defined herein.
  • Fig. 1 shows a perspective view of a product according to the invention packaged in a microorganism-impermeable pouch
  • Fig. 2 shows a perspective exploded view of a first product according to the invention
  • Fig. 3 shows a partially cut away view of part of the product of Fig. 2;
  • Fig. 4 shows a perspective exploded view of a second product according to the invention
  • Fig. 5 shows a partially cut away view of part of the product of Fig. 4;
  • Fig. 6 shows a perspective exploded view of a third product according to the invention
  • Fig. 7 shows a perspective exploded view of a fourth product according to the invention
  • Fig. 8 shows a partially cut away view of part of the product of Fig. 7;
  • Fig. 9 shows a perspective exploded view of a fifth product according to the invention.
  • Fig. 10 shows a partially cut away view of part of the product of Fig. 9;
  • Fig. 1 1 shows a perspective view of a sixth product according to the invention
  • Fig. 12 shows a perspective exploded view of a seventh product according to the invention.
  • FIG. 13 shows a perspective view of the product of Fig. 12;
  • Fig. 14 shows a perspective partially exploded view of an eighth product according to the invention;
  • Fig. 15 shows a perspective exploded view of a ninth product according to the invention.
  • Fig. 16 shows a perspective view of the product of Fig. 15 ;
  • Fig. 17 shows a schematic drawing of the loop tack test configuration used in Procedure 1 below.
  • Fig. 18 shows a schematic drawing of the peel strength test configuration used in Procedure 2 below.
  • a packaged wound dressing 1 according to the invention is shown.
  • the dressing 2 is sterile and packaged in a microorganism-impermeable envelope 3 of polypropylene or the like having a transparent window 4.
  • the siliconized substrate 5 in this and all of the other embodiments shown in the drawings comprises a substrate of cellulose acetate gauze of density 107 grams per square meter nominal, coated with a hydrophobic, tacky, crosslinked silicone gel, prepared as described below.
  • the silicone composition penetrates the gauze to form a single, chemically homogeneous silicone phase coating the strands of the gauze.
  • the coated substrate 5 has an array of apertures extending through the substrate and the silicone to allow passage of wound fluid through the material.
  • the nominal total coating weight of the silicone is 120-130 grams per square meter.
  • the upper siliconized surface is bonded to a base layer 6, which in this embodiment is a semipermeable microporous polyurethane backing layer, which may or may not be coated with a polyurethane pressure-sensitive adhesive layer.
  • the opposite surface of the siliconized substrate is covered by a release sheet 7 of siliconized paper that can be peeled off to expose the siliconized surface for application to a wound or to skin.
  • the product 10 comprises a siliconized substrate gauze 5 and releasable cover sheet 7 as before, but in this embodiment the base layer 11 is a sheet of water-absorbent hydrophilic polyurethane foam prepared as described in EP-A-0541391. The foam can absorb wound fluid and swell in use, while remaining strongly bonded to the siliconized gauze wound contacting layer 5.
  • the product according to this embodiment comprises a siliconized substrate gauze 5 as before, but in this embodiment the base layer 12 is a sheet of water- absorbent nonwoven textile, such as a nonwoven viscose web or a nonwoven alginate/nylon web.
  • the absorbent textile 12 can absorb wound fluid and swell in use, while remaining strongly bonded to the siliconized gauze wound contacting layer 5.
  • a backing sheet 14 of semipermeable film coated with adhesive 15 is applied over the opposite surface of the textile layer to prevent leakage of liquid from the back of the dressing.
  • the product according to this embodiment comprises a siliconized substrate gauze 5 laminated to a hydrophilic foam layer and cover sheet as for the embodiment of Fig. 4.
  • the embodiment of Figs 7 and 8 further comprises a backing sheet 14 of adhesive-coated semipermeable film as described for Fig. 6 that is applied over the opposite surface of the foam layer from the siliconized substrate to prevent leakage of liquid through the dressing.
  • the product 16 is an island dressing. It comprises a siliconized substrate gauze 5 laminated to a hydrophilic liquid- absorbent layer of textile material 17 and a polyurethane semipemeable backing sheet 1 as for the embodiment of Fig. 6.
  • a silicone-coated paper release sheet 7 is provided over the wound-facing surface of the gauze 5.
  • the area of the textile material 17 is less than that of the gauze 5 or the backing sheet 14, whereby a margin 18 of the backing sheet extends around all edges of the textile material.
  • the siliconized gauze is therefore directly bonded to the backing sheet over the margin, as well as to the wound-facing surface of the textile layer 17.
  • This bonding of the siliconized gauze to the margin 18 of the backing sheet 14 helps to keep the absorbent island in place on the backing sheet, and also provides the margin 18 with a skin-friendly, weakly adherent (tacky) siliconized surface for contact with the skin around a wound.
  • the island dressings are less prone to leakage of wound fluids from the edges of the dressing than the simple laminates described above.
  • the product 20 is an envelope-type dressing formed from upper and lower sheets 5,19 of siliconized gauze, which may be separate sheets or a single sheet folded over.
  • An island 17 of hydrophilic liquid-absorbent textile material is located centrally between the sheets 5,19.
  • the sheets 5,1 are bonded to the island 17 and to each other in the marginal area around the island 17.
  • the resulting envelope can be applied to a wound in either orientation.
  • the product 21 is an island dressing similar to that of Figs. 9 and 10. It comprises a siliconized substrate gauze 5 laminated to a hydrophilic liquid-absorbent layer of textile material 17 and a polyurethane semipemeable backing sheet 14 as for the embodiment of Fig. 6. A layer of polyurethane pressure-sensitive adhesive 15 is provided over the wound-facing surface of the backing sheet 14.
  • the gauze 5 is coterminous with the island 7 so that the margin 18 is solely adhesive-coated to provide adhesion to skin around a wound. Referring to Fig.
  • an alternative island dressing structure is shown wherein the siliconized gauze layer 5 is laminated directly to a semipermeable polyurethane backing sheet 14, and an absorbent island 17 is laminated over and bonded to the gauze layer 5.
  • the gauze layer 5 acts as a tie layer to bond the absorbent island 17 to the backing sheet.
  • a further siliconized gauze layer (not shown) may be bonded over the top of the absorbent layer, either coterminous with the absorbent layer 17 or coterminous with the backing sheet 14, in similar fashion as for the embodiments of Figs. 9-10 or 12-13.
  • this embodiment is a sandwich structure having upper and lower sheets of siliconized gauze 5,19 sandwiching and bonded to a layer of nonwoven textile absorbent material 12.
  • the layers 5,12 and 19 are coterminous, or a small margin 24 of layers 5,19 directly bonded to each other may extend around the edges of the dressing.
  • the products according to the invention may be made by a process according to the invention. This process starts from a continuous web of cellulose acetate gauze that is passed through a fluid silicone coating composition and nip rollers to coat and impregnate the gauze with the silicone composition.
  • the silicone coating composition is prepared by mixing Components A and B of a soft silicone skin adhesive silicone elastomer kit supplied by Dow Corning under product reference Q7-9177. The components are mixed in weight ratio 50:50.
  • Component A comprises a bis- dimethylvinyl terminated polydimethylsiloxane and a platinum catalyst.
  • Component B comprises a bis-hydride terminated polydimethylsiloxane. To the mixture is added 2- methyl-3-butyn-2-ol inhibitor at a concentration of 0.02wt.%.
  • the coated substrate then passes over a blower 17 to open the apertures of the coated substrate that may have been occluded by the silicone.
  • the coated gauze is then passed through an oven 18 held at 150°C. Typical conditions are 5 passes at 4.2m/min, total residence time 1.5 minutes. This results in thermal partial cure of the silicone coating.
  • the coated material is then allowed to cool, and the base layer and a release coated paper cover sheet are then continuously applied to the upper and lower surfaces.
  • the material is then cut and packaged as shown in Fig. 1, followed by gamma irradiation with 35-50kGy of Cobalt 60 radiation at 7-9kGy/hr to sterilize the products and complete the cure.
  • the irradiation curing results in a further increase in both hardness and tackiness of the silicone coating, and further bonds the silicone coating strongly to the base layer.
  • the tackiness of the silicone coatings produced by the methods of the invention was measured in a tensile tester, such as an Instron tester, using the set-up shown in Fig. 17.
  • Samples of the coated fully cured gauze laminates were cut to dimensions 5 x 9.5 cm. Margins of 1cm were marked out along the long edges by drawing straight lines 1cm from the long edges. The cover sheets were removed, and the sheet of coated gauze 30 was looped around and the 1cm margins 30,32 on opposed edges of one surface (opposite the surface being measured) were applied firmly to opposite sides of a 2mm thick metal spacer bar 34. Strips of polypropylene film 1cm wide 36,37 were then applied to the opposite surfaces of the coated gauze opposite the spacer bar 34 to prevent the coated gauze from adhering to the jaws of the measurement device.
  • the assembly of polypropylene strips, coated gauze and spacer bar was then gripped in the jaws 38 of the Instron tester.
  • the loop of coated gauze 40 having the surface under test outermost was then lowered onto a clean polycarbonate surface 42 of dimensions 15.5cm x 3.8cm so that the loop adheres to the surface, and raised to detach the loop from the surface. Lowering and raising are performed at 300mm/min, and the minimum distance between the jaws 38 and the polycarbonate surface 42 is 15mm.
  • the measured tack (in Newtons) is the maximum force measured while detaching the loop from the surface. Average of three measurements was used.
  • the peel strength of the laminates produced by the methods of the invention was measured in a tensile tester, such as an Instron tester, using the set-up shown schematically in Fig. 18.
  • the test strip 50 is positioned horizontally with the substrate layer and base layer in respective jaws 52,54 of the tester to give 180 degree peel.
  • the test was performed on strips of laminate of dimensions 25.4mm x 254mm.
  • the pull rate was 400nrai/minute.
  • the first sample comprises a silicone-coated gauze (ADAPTIC TOUCH available from Systagenix Wound Management Manufacturing Ltd., Gargrave, UK) laminated to a polyurethane hydrophilic foam sheet (TIELLE, available from Systagenix Wound Management Manufacturing Ltd., Gargrave, UK). Peel strength tests on the laminate before and after the final gamma sterilization and crossiinking step are shown in Table 1 below.
  • ADAPTIC TOUCH available from Systagenix Wound Management Manufacturing Ltd., Gargrave, UK
  • TIELLE available from Systagenix Wound Management Manufacturing Ltd., Gargrave, UK
  • the siliconized substrate adheres only weakly to the foam before irradiation, but exhibits strong bonding after irradiation.
  • Example 1 The method of Example 1 was repeated to prepare a laminate of a silicone-coated gauze (ADAPTIC TOUCH available from Systagenix Wound Management Manufacturing Ltd., Gargrave, UK) laminated to a semipermeable wound dressing backing sheet formed of 0.4mm high-density polyurethane foam of a blocked toluene di-isocyanate nature coated with an aliphatic polyurethane adhesive.
  • ADAPTIC TOUCH available from Systagenix Wound Management Manufacturing Ltd., Gargrave, UK
  • the siliconised apertured substrate can thus provide a non-adherent wound contacting surface to the polyurethane backing sheet.
  • Example 1 The method of Example 1 was repeated to prepare a laminate of a silicone-coated gauze (ADAPTIC TOUCH available from Systagenix Wound Management Manufacturing Ltd., Gargrave, UK) laminated to second sheet of the same silicone-coated gauze.
  • ADAPTIC TOUCH available from Systagenix Wound Management Manufacturing Ltd., Gargrave, UK
  • Peel strength tests on the laminate before and after the final gamma sterilization and crosslinking step are shown in Table 3 below.
  • Example 1 The method of Example 1 was repeated to prepare a laminate of a silicone-coated gauze (ADAPTIC TOUCH ® available from Systagenix Wound Management Manufacturing Ltd., Gar grave, UK) laminated to sheet of nonwoven textile (SILVERCEL ® available from Systagenix Wound Management Manufacturing Ltd., Gargrave, UK).
  • the textile is a calcium alginate needled felt dressing incorporating metallic-silver-coated nylon fibers.
  • the composition is as follows, by weight: calcium alginate and carboxymethyl cellulose (CMC) fibers 60% and silver coated nylon 40%.
  • the basis weight of the fabric layer is about 150 g/m 2 , and the uncompressed thickness of the fabric layer is about 2 mm.
  • the total silver content of the fabric is about 8 wt.%.
  • the siliconized substrate adheres only weakly to itself before irradiation, but exhibits strong bonding after irradiation. In fact, under the peel test conditions the siliconized substrate does not peel from the surface of the textile, but instead the textile itself peels apart.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
PCT/GB2012/000099 2011-01-31 2012-01-31 Silicone wound dressing laminate and method for making the same WO2012104584A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP12705381.7A EP2670369B1 (de) 2011-01-31 2012-01-31 Silikonwundverbandlaminat und herstellungsverfahren dafür
US13/982,650 US10568767B2 (en) 2011-01-31 2012-01-31 Silicone wound dressing laminate and method for making the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1101662.3 2011-01-31
GB1101662.3A GB2488749A (en) 2011-01-31 2011-01-31 Laminated silicone coated wound dressing

Publications (1)

Publication Number Publication Date
WO2012104584A1 true WO2012104584A1 (en) 2012-08-09

Family

ID=43824886

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2012/000099 WO2012104584A1 (en) 2011-01-31 2012-01-31 Silicone wound dressing laminate and method for making the same

Country Status (4)

Country Link
US (2) US10568767B2 (de)
EP (1) EP2670369B1 (de)
GB (1) GB2488749A (de)
WO (1) WO2012104584A1 (de)

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2493960A (en) * 2011-08-25 2013-02-27 Brightwake Ltd Wound dressing comprising perforated sheet impregnated with silicone gel
WO2014108476A1 (de) * 2013-01-09 2014-07-17 Birgit Riesinger Flüssigkeitsdurchlässiger primärverband mit einer silikonbeschichtung
US20140330227A1 (en) 2010-03-16 2014-11-06 Kci Licensing, Inc. Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US20150119831A1 (en) 2013-10-30 2015-04-30 Kci Licensing, Inc. Condensate absorbing and dissipating system
USD733896S1 (en) 2012-05-04 2015-07-07 Genadyne Biotechnologies, Inc. Abdominal dressing
US20160166726A1 (en) * 2014-12-11 2016-06-16 Gergonne Sas Non adherent healing interface and associated compress and dressing
EP3092991A1 (de) * 2012-12-18 2016-11-16 Systagenix Wound Management IP Co. BV. Wundverband mit klebstoffrand
US9861532B2 (en) 2011-12-16 2018-01-09 Kci Licensing, Inc. Releasable medical drapes
US9925092B2 (en) 2013-10-30 2018-03-27 Kci Licensing, Inc. Absorbent conduit and system
US9956120B2 (en) 2013-10-30 2018-05-01 Kci Licensing, Inc. Dressing with sealing and retention interface
US10010656B2 (en) 2008-03-05 2018-07-03 Kci Licensing, Inc. Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US10016544B2 (en) 2013-10-30 2018-07-10 Kci Licensing, Inc. Dressing with differentially sized perforations
US10086107B2 (en) 2006-04-03 2018-10-02 Brightwake Limited Adhesive laminates and applications thereof
US10117978B2 (en) 2013-08-26 2018-11-06 Kci Licensing, Inc. Dressing interface with moisture controlling feature and sealing function
US10226566B2 (en) 2014-04-23 2019-03-12 Genadyne Biotechnologies, Inc. System and process for removing bodily fluids from a body opening
WO2019027401A3 (en) * 2017-05-05 2019-03-21 T.C. Istanbul Medipol Universitesi DRESSING ARTICLE
US10299966B2 (en) 2007-12-24 2019-05-28 Kci Usa, Inc. Reinforced adhesive backing sheet
US10357406B2 (en) 2011-04-15 2019-07-23 Kci Usa, Inc. Patterned silicone coating
US10398604B2 (en) 2014-12-17 2019-09-03 Kci Licensing, Inc. Dressing with offloading capability
US10406266B2 (en) 2014-05-02 2019-09-10 Kci Licensing, Inc. Fluid storage devices, systems, and methods
US10561534B2 (en) 2014-06-05 2020-02-18 Kci Licensing, Inc. Dressing with fluid acquisition and distribution characteristics
US10568767B2 (en) 2011-01-31 2020-02-25 Kci Usa, Inc. Silicone wound dressing laminate and method for making the same
US10632020B2 (en) 2014-02-28 2020-04-28 Kci Licensing, Inc. Hybrid drape having a gel-coated perforated mesh
US10842707B2 (en) 2012-11-16 2020-11-24 Kci Licensing, Inc. Medical drape with pattern adhesive layers and method of manufacturing same
US10940047B2 (en) 2011-12-16 2021-03-09 Kci Licensing, Inc. Sealing systems and methods employing a hybrid switchable drape
US10946124B2 (en) 2013-10-28 2021-03-16 Kci Licensing, Inc. Hybrid sealing tape
US10973694B2 (en) 2015-09-17 2021-04-13 Kci Licensing, Inc. Hybrid silicone and acrylic adhesive cover for use with wound treatment
US11026844B2 (en) 2014-03-03 2021-06-08 Kci Licensing, Inc. Low profile flexible pressure transmission conduit
US11096830B2 (en) 2015-09-01 2021-08-24 Kci Licensing, Inc. Dressing with increased apposition force
US11246975B2 (en) 2015-05-08 2022-02-15 Kci Licensing, Inc. Low acuity dressing with integral pump
US11944521B2 (en) 2015-11-13 2024-04-02 First Water Limited Compositions for application to wounds

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808376D0 (en) 2008-05-08 2008-06-18 Bristol Myers Squibb Co Wound dressing
GB0817796D0 (en) 2008-09-29 2008-11-05 Convatec Inc wound dressing
GB201020236D0 (en) 2010-11-30 2011-01-12 Convatec Technologies Inc A composition for detecting biofilms on viable tissues
CA2819475C (en) 2010-12-08 2019-02-12 Convatec Technologies Inc. Integrated system for assessing wound exudates
CA2819549C (en) 2010-12-08 2019-09-10 Convatec Technologies Inc. Wound exudate system accessory
GB201108229D0 (en) 2011-05-17 2011-06-29 Smith & Nephew Tissue healing
GB201115182D0 (en) 2011-09-02 2011-10-19 Trio Healthcare Ltd Skin contact material
GB2497406A (en) 2011-11-29 2013-06-12 Webtec Converting Llc Dressing with a perforated binder layer
GB201120693D0 (en) 2011-12-01 2012-01-11 Convatec Technologies Inc Wound dressing for use in vacuum therapy
US10182948B2 (en) 2012-08-16 2019-01-22 Beijing Beishute Maternity & Child Articles Co., Ltd. Method and device for making absorbent cores used in disposable hygiene pad
US20150354096A1 (en) 2012-12-20 2015-12-10 Convatec Technologies Inc. Processing of chemically modified cellulosic fibres
USD777332S1 (en) * 2013-10-29 2017-01-24 Beijing Beishute Maternity & Child Articles Co., Ltd. Absorbent pad
CN103611184A (zh) * 2013-11-27 2014-03-05 长春吉原生物科技有限公司 一种复合半透膜的水凝胶及其制备方法
USD770631S1 (en) * 2014-05-27 2016-11-01 Precision Medical Devices, Llc Device to close wounds
USD869960S1 (en) * 2014-05-30 2019-12-17 rotaris Marketing GmbH Floral packaging
USD785188S1 (en) * 2014-09-05 2017-04-25 Marie Cilone Bandage
EP3191041B1 (de) 2014-09-10 2022-06-08 C. R. Bard, Inc. Schützender verband für auf der haut positionierte medizinische vorrichtung
USD790071S1 (en) * 2015-10-19 2017-06-20 Mölnlycke Health Care Ab Wound dressing
USD745973S1 (en) * 2015-07-02 2015-12-22 Ronald D. Russo Re-sealable wound dressing
EP3373983A4 (de) * 2015-11-10 2019-06-12 Materials Modification Inc. Multifunktioneller transdermaler verband für wunden
US20170143103A1 (en) * 2015-11-19 2017-05-25 Giselle Howard Anti-wrinkling pad and method
WO2017127369A1 (en) * 2016-01-19 2017-07-27 Kci Usa, Inc. A silicone wound contact layer with silver
US20170209312A1 (en) * 2016-01-22 2017-07-27 Covidien Lp Absorbent articles including silicone
TW201800069A (zh) 2016-03-30 2018-01-01 康華特科技有限公司 傷口中微生物感染檢測方法
US20230213525A1 (en) 2016-03-30 2023-07-06 Qualizyme Diagnostics Gmbh & Co Kg Detecting microbial infection in wounds
US20190282406A1 (en) * 2016-05-18 2019-09-19 Ga International Inc. Stretchable bandage tape and method of use
JP2019525799A (ja) 2016-07-08 2019-09-12 コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ 流体収集装置
EP3871645B1 (de) 2016-07-08 2022-05-04 ConvaTec Technologies Inc. Flexibles unterdrucksystem
KR20190028725A (ko) 2016-07-08 2019-03-19 컨바텍 테크놀러지스 인크 체액 흐름 감지
CN108251044B (zh) * 2016-12-28 2020-12-25 比亚迪股份有限公司 一种有机硅底涂液和双玻组件
RU2019139911A (ru) 2017-06-07 2021-07-09 Кейсиай ЛАЙСЕНСИНГ, ИНК. Композитные перевязочные материалы для улучшенной грануляции и сниженной мацерации для лечения посредством отрицательного давления
US11471332B2 (en) 2017-06-07 2022-10-18 Kci Licensing, Inc. Systems, apparatuses, and methods for negative-pressure treatment with reduced tissue in-growth
US11607342B2 (en) 2017-06-07 2023-03-21 Kci Licensing, Inc. Peel and place dressing for negative-pressure therapy
KR20200016934A (ko) 2017-06-07 2020-02-17 케이씨아이 라이센싱 인코포레이티드 음압 치료를 이용한 육아 개선 및 침연 감소용 복합 드레싱재
WO2018226627A1 (en) 2017-06-07 2018-12-13 Kci Licensing, Inc. Composite dressings for improved granulation and reduced maceration with negative-pressure treatment
EP3634337B1 (de) 2017-06-07 2023-05-24 3M Innovative Properties Company Verfahren zur herstellung und montage einer gewebeschnittstelle aus zwei materialien für unterdrucktherapie
JP2020523077A (ja) 2017-06-07 2020-08-06 ケーシーアイ ライセンシング インコーポレイテッド 陰圧治療による肉芽形成の促進及び浸軟の低減のための複合ドレッシング
GB201804502D0 (en) * 2018-03-21 2018-05-02 Smith & Nephew Biocompatible encapsulation and component stress relief for sensor enabled negative pressure wound therapy dressings
USD851261S1 (en) 2018-05-11 2019-06-11 Avery Dennison Corporation Medical connection pad
USD876647S1 (en) * 2018-08-13 2020-02-25 Sian Fong Technology Industrial Co., Ltd. Health patch
CN109171862B (zh) * 2018-09-11 2024-08-20 李晓阳 一种适用于硬化剂治疗后的静脉压迫贴
EP3856266A1 (de) * 2018-09-25 2021-08-04 Systagenix Wound Management, Limited Wundverbandzusammensetzungen und verwendungen davon
USD916296S1 (en) 2018-11-12 2021-04-13 Mölnlycke Health Care Ab Wound dressing
US20200323694A1 (en) * 2019-04-09 2020-10-15 Bio Med Sciences, Inc. Layered apertured wound dressing, process of manufacture and useful articles thereof
SG11202112292QA (en) 2019-06-03 2021-12-30 Convatec Ltd Methods and devices to disrupt and contain pathogens
US11771819B2 (en) 2019-12-27 2023-10-03 Convatec Limited Low profile filter devices suitable for use in negative pressure wound therapy systems
US11331221B2 (en) 2019-12-27 2022-05-17 Convatec Limited Negative pressure wound dressing
US20210337901A1 (en) * 2020-04-30 2021-11-04 Daniel William Jette Attachable, removable, and disposable sweatband strip
US20240207143A1 (en) 2021-04-29 2024-06-27 Reza Mollaaghababa Articles for streamlined skin rejuvenation and wound healing using exosomes and prp
DE102021118759A1 (de) * 2021-07-20 2023-01-26 Paul Hartmann Ag Strahlenvernetzung und Sterilisation von Silicon

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1280631A (en) 1968-07-09 1972-07-05 Smith & Nephew Adhesive materials
GB1301101A (en) 1969-01-08 1972-12-29 Secr Defence Improvements in the manufacture of carbon
EP0053936A2 (de) 1980-12-08 1982-06-16 Johnson & Johnson Products Inc. Chirurgische Verbände
GB2127389A (en) 1982-09-13 1984-04-11 Charcoal Cloth Ltd Activated carbon products and their manufacture
EP0117632A2 (de) 1983-01-27 1984-09-05 Johnson & Johnson Products Inc. Filmheftpflaster
WO1987005206A1 (en) 1986-03-10 1987-09-11 Mölnlycke AB Wound dressing
EP0251810A2 (de) 1986-07-04 1988-01-07 JOHNSON & JOHNSON Wundverband
US4871611A (en) * 1985-11-15 1989-10-03 Mead Release Products, Inc. Breathable backing or release liner and process for forming the same
EP0342950A2 (de) 1988-05-18 1989-11-23 SMITH & NEPHEW plc Wundverband
EP0541391A1 (de) 1991-11-07 1993-05-12 JOHNSON & JOHNSON MEDICAL, INC. Verfahren zur Herstellung von Polyurethan-Schaumstoff
WO1993019710A1 (en) 1992-03-30 1993-10-14 Mölnlycke AB An absorbent wound dressing
EP1002846A1 (de) * 1998-11-19 2000-05-24 Minnesota Mining And Manufacturing Company Klebeband für ein Windelverschlusssystem
WO2003053584A2 (en) 2001-12-20 2003-07-03 Board Of Regents, The University Of Texas System Dielectric gate and methods for fluid injection and control
US20050113732A1 (en) * 2001-04-19 2005-05-26 Roger Lawry Scar tissue treatment bandage and method
WO2010005654A2 (en) 2008-07-03 2010-01-14 Chevron U.S.A. Inc. System and method for separating a trace element from a liquid hydrocarbon feed

Family Cites Families (391)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3172808A (en) 1965-03-09 Method of treating wounds
US1355846A (en) 1920-02-06 1920-10-19 David A Rannells Medical appliance
US2547758A (en) 1949-01-05 1951-04-03 Wilmer B Keeling Instrument for treating the male urethra
US2632443A (en) 1949-04-18 1953-03-24 Eleanor P Lesher Surgical dressing
GB692578A (en) 1949-09-13 1953-06-10 Minnesota Mining & Mfg Improvements in or relating to drape sheets for surgical use
US2682873A (en) 1952-07-30 1954-07-06 Johnson & Johnson General purpose protective dressing
NL189176B (nl) 1956-07-13 1900-01-01 Hisamitsu Pharmaceutical Co Pleister op basis van een synthetische rubber.
US2969057A (en) 1957-11-04 1961-01-24 Brady Co W H Nematodic swab
US3066672A (en) 1960-09-27 1962-12-04 Jr William H Crosby Method and apparatus for serial sampling of intestinal juice
GB1052614A (de) 1964-06-04
US3367332A (en) 1965-08-27 1968-02-06 Gen Electric Product and process for establishing a sterile area of skin
US3520300A (en) 1967-03-15 1970-07-14 Amp Inc Surgical sponge and suction device
US3777016A (en) 1967-10-31 1973-12-04 J Gilbert Composition and method for the treat-ment of damaged skin
US3568675A (en) 1968-08-30 1971-03-09 Clyde B Harvey Fistula and penetrating wound dressing
US4141361A (en) 1970-02-09 1979-02-27 Snyder Manufacturing Co., Incorporated Evacuator
US3682180A (en) 1970-06-08 1972-08-08 Coilform Co Inc Drain clip for surgical drain
BE789293Q (fr) 1970-12-07 1973-01-15 Parke Davis & Co Pansement medico-chirugical pour brulures et lesions analogues
US3742952A (en) 1971-04-28 1973-07-03 Alpha Ind Inc Surgical suction pump assembly
US3779243A (en) 1971-10-15 1973-12-18 J Tussey Contamination free surgical evacuator
GB1386800A (en) 1971-10-27 1975-03-12 Johnson & Johnson Self-adhesive disposable surgical drape
US3852823A (en) 1972-03-08 1974-12-10 J Jones Method of sealing a bathing or shower cap to the head of the wearer
US3774611A (en) 1972-06-08 1973-11-27 J Tussey Stabilized contamination free surgical evacuator
US3983297A (en) 1972-06-14 1976-09-28 Teijin Limited Pressure-sensitive adhesive tape or drape
US3826254A (en) 1973-02-26 1974-07-30 Verco Ind Needle or catheter retaining appliance
US3903882A (en) * 1974-04-19 1975-09-09 American Cyanamid Co Composite dressing
US3967624A (en) 1975-04-04 1976-07-06 Johnson & Johnson Disposable diaper with tab fasteners having a perforated cover strip
DE2527706A1 (de) 1975-06-21 1976-12-30 Hanfried Dr Med Weigand Einrichtung zum einleiten von kontrastmittel in einen kuenstlichen darmausgang
US4060081A (en) * 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
GB1563695A (en) 1975-07-29 1980-03-26 Smith & Nephew Res Adhesive material
DE2640413C3 (de) 1976-09-08 1980-03-27 Richard Wolf Gmbh, 7134 Knittlingen Katheter-Überwachungsgerät
NL7710909A (nl) 1976-10-08 1978-04-11 Smith & Nephew Samengestelde hechtstrook.
GB1562244A (en) 1976-11-11 1980-03-05 Lock P M Wound dressing materials
US4080970A (en) 1976-11-17 1978-03-28 Miller Thomas J Post-operative combination dressing and internal drain tube with external shield and tube connector
US4139004A (en) 1977-02-17 1979-02-13 Gonzalez Jr Harry Bandage apparatus for treating burns
US4184510A (en) 1977-03-15 1980-01-22 Fibra-Sonics, Inc. Valued device for controlling vacuum in surgery
US4165748A (en) 1977-11-07 1979-08-28 Johnson Melissa C Catheter tube holder
US4256109A (en) 1978-07-10 1981-03-17 Nichols Robert L Shut off valve for medical suction apparatus
SE414994B (sv) 1978-11-28 1980-09-01 Landstingens Inkopscentral Venkateterforband
BR7908937A (pt) 1978-12-06 1981-06-30 Svedman Paul Dispositivo para tratamento de tecidos,por exemplo,pele
US4266545A (en) 1979-04-06 1981-05-12 Moss James P Portable suction device for collecting fluids from a closed wound
US4284079A (en) 1979-06-28 1981-08-18 Adair Edwin Lloyd Method for applying a male incontinence device
US4261363A (en) 1979-11-09 1981-04-14 C. R. Bard, Inc. Retention clips for body fluid drains
US4569348A (en) 1980-02-22 1986-02-11 Velcro Usa Inc. Catheter tube holder strap
WO1981002516A1 (en) 1980-03-11 1981-09-17 E Schmid Cushion for holding an element of grafted skin
US5445604A (en) 1980-05-22 1995-08-29 Smith & Nephew Associated Companies, Ltd. Wound dressing with conformable elastomeric wound contact layer
US4297995A (en) 1980-06-03 1981-11-03 Key Pharmaceuticals, Inc. Bandage containing attachment post
US4529402A (en) 1980-07-08 1985-07-16 Snyder Laboratories, Inc. Closed wound suction evacuator with rotary valve
NZ197782A (en) 1980-07-30 1985-07-31 Smith & Nephew Ass A moisture vapour transmitting elastic bandage
US4333468A (en) 1980-08-18 1982-06-08 Geist Robert W Mesentery tube holder apparatus
US4995382A (en) 1981-02-13 1991-02-26 Smith And Nephew Associated Companies Limited Wound dressing, manufacture and use
US4465485A (en) 1981-03-06 1984-08-14 Becton, Dickinson And Company Suction canister with unitary shut-off valve and filter features
US4392853A (en) 1981-03-16 1983-07-12 Rudolph Muto Sterile assembly for protecting and fastening an indwelling device
US4360015A (en) 1981-05-14 1982-11-23 Hartford Corporation Multilayer absorbent structure
US4373519A (en) 1981-06-26 1983-02-15 Minnesota Mining And Manufacturing Company Composite wound dressing
US4392858A (en) 1981-07-16 1983-07-12 Sherwood Medical Company Wound drainage device
US4419097A (en) 1981-07-31 1983-12-06 Rexar Industries, Inc. Attachment for catheter tube
AU550575B2 (en) 1981-08-07 1986-03-27 Richard Christian Wright Wound drainage device
SE429197B (sv) 1981-10-14 1983-08-22 Frese Nielsen Anordning for behandling av sar
DE3146266A1 (de) 1981-11-21 1983-06-01 B. Braun Melsungen Ag, 3508 Melsungen Kombinierte vorrichtung fuer eine medizinische saugdrainage
US4551139A (en) 1982-02-08 1985-11-05 Marion Laboratories, Inc. Method and apparatus for burn wound treatment
US4475909A (en) 1982-05-06 1984-10-09 Eisenberg Melvin I Male urinary device and method for applying the device
EP0097517B1 (de) 1982-06-22 1987-06-24 Smith and Nephew Associated Companies p.l.c. Wundverband, seine Herstellung und Verwendung
EP0100148B1 (de) 1982-07-06 1986-01-08 Dow Corning Limited Medizinischer chirurgischer Wundverband und Verfahren zu seiner Herstellung
US4548202A (en) 1983-06-20 1985-10-22 Ethicon, Inc. Mesh tissue fasteners
US4540412A (en) 1983-07-14 1985-09-10 The Kendall Company Device for moist heat therapy
US4543100A (en) 1983-11-01 1985-09-24 Brodsky Stuart A Catheter and drain tube retainer
GB8334484D0 (en) 1983-12-24 1984-02-01 Smith & Nephew Ass Surgical dressing
US4525374A (en) 1984-02-27 1985-06-25 Manresa, Inc. Treating hydrophobic filters to render them hydrophilic
GB2157958A (en) 1984-05-03 1985-11-06 Ernest Edward Austen Bedding Ball game net support
US4897081A (en) 1984-05-25 1990-01-30 Thermedics Inc. Percutaneous access device
US5215522A (en) 1984-07-23 1993-06-01 Ballard Medical Products Single use medical aspirating device and method
GB8419745D0 (en) 1984-08-02 1984-09-05 Smith & Nephew Ass Wound dressing
US4872450A (en) 1984-08-17 1989-10-10 Austad Eric D Wound dressing and method of forming same
US4826494A (en) 1984-11-09 1989-05-02 Stryker Corporation Vacuum wound drainage system
US4655754A (en) 1984-11-09 1987-04-07 Stryker Corporation Vacuum wound drainage system and lipids baffle therefor
US4605399A (en) 1984-12-04 1986-08-12 Complex, Inc. Transdermal infusion device
US4664652A (en) 1985-02-07 1987-05-12 Snyder Laboratories, Inc. Wound evacuator
GB8509977D0 (en) 1985-04-18 1985-05-30 Juhasz L Wound dressings
US5037397A (en) 1985-05-03 1991-08-06 Medical Distributors, Inc. Universal clamp
GB2176401A (en) 1985-06-12 1986-12-31 Vernon Carus Ltd Wound dressing
US4640688A (en) 1985-08-23 1987-02-03 Mentor Corporation Urine collection catheter
US4710165A (en) 1985-09-16 1987-12-01 Mcneil Charles B Wearable, variable rate suction/collection device
US4758220A (en) 1985-09-26 1988-07-19 Alcon Laboratories, Inc. Surgical cassette proximity sensing and latching apparatus
US4733659A (en) 1986-01-17 1988-03-29 Seton Company Foam bandage
EP0256060A1 (de) 1986-01-31 1988-02-24 OSMOND, Roger L. W. Absaugungssystem für wund-, magen- und darmdrainage
JPS62139523U (de) 1986-02-14 1987-09-03
US4838883A (en) 1986-03-07 1989-06-13 Nissho Corporation Urine-collecting device
DE3778195D1 (de) * 1986-04-07 1992-05-21 Agency Ind Science Techn Antithrombogenisches material.
JPS62275456A (ja) 1986-05-22 1987-11-30 帝三製薬株式会社 創傷保護材
DE3772453D1 (de) 1986-05-28 1991-10-02 Lohmann Therapie Syst Lts Fixiersystem zur befestigung von kathetern, kanuelen oder dgl. auf der hautoberflaeche.
JPS62281965A (ja) 1986-05-29 1987-12-07 テルモ株式会社 カテ−テルおよびカテ−テル用固定部材
GB8621884D0 (en) 1986-09-11 1986-10-15 Bard Ltd Catheter applicator
GB2195255B (en) 1986-09-30 1991-05-01 Vacutec Uk Limited Apparatus for vacuum treatment of an epidermal surface
US4743232A (en) 1986-10-06 1988-05-10 The Clinipad Corporation Package assembly for plastic film bandage
DE3634569A1 (de) 1986-10-10 1988-04-21 Sachse Hans E Kondomkatheter, ein harnroehrenkatheter zur verhinderung von aufsteigenden infektionen
NL8602662A (nl) 1986-10-23 1988-05-16 Patentico Ltd In vormvaste toestand te brengen afdekblad.
JPS63135179A (ja) 1986-11-26 1988-06-07 立花　俊郎 薬物の経皮投与具
GB8628564D0 (en) 1986-11-28 1987-01-07 Smiths Industries Plc Anti-foaming agent suction apparatus
US4867150A (en) 1987-01-20 1989-09-19 The B. F. Goodrich Company Perforated elastomeric soft film and wound dressing made therewith
CN87101823B (zh) * 1987-03-12 1988-10-05 铁汉 医用不粘敷料
GB8706116D0 (en) 1987-03-14 1987-04-15 Smith & Nephew Ass Adhesive dressings
US4787888A (en) 1987-06-01 1988-11-29 University Of Connecticut Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)
US5356386A (en) 1987-06-05 1994-10-18 Uresil Corporation Apparatus for locating body cavities
US4863449A (en) 1987-07-06 1989-09-05 Hollister Incorporated Adhesive-lined elastic condom cathether
US4930997A (en) 1987-08-19 1990-06-05 Bennett Alan N Portable medical suction device
US5176663A (en) 1987-12-02 1993-01-05 Pal Svedman Dressing having pad with compressibility limiting elements
US5018515A (en) 1987-12-14 1991-05-28 The Kendall Company See through absorbent dressing
US4906240A (en) 1988-02-01 1990-03-06 Matrix Medica, Inc. Adhesive-faced porous absorbent sheet and method of making same
US4832008A (en) 1988-02-09 1989-05-23 The Kendall Company Wound dressing with release sheets strip
US4981474A (en) 1988-02-16 1991-01-01 Baxter Travenol Laboratories, Inc. Body fluid drainage device
US4985019A (en) 1988-03-11 1991-01-15 Michelson Gary K X-ray marker
GB8812096D0 (en) 1988-05-21 1988-06-22 Smith & Nephew Ass Adhesive sheet
GB8812803D0 (en) 1988-05-28 1988-06-29 Smiths Industries Plc Medico-surgical containers
US5374261A (en) 1990-07-24 1994-12-20 Yoon; Inbae Multifunctional devices for use in endoscopic surgical procedures and methods-therefor
US4919654A (en) 1988-08-03 1990-04-24 Kalt Medical Corporation IV clamp with membrane
US5000741A (en) 1988-08-22 1991-03-19 Kalt Medical Corporation Transparent tracheostomy tube dressing
JPH046760Y2 (de) 1988-12-27 1992-02-24
JPH02270874A (ja) 1989-01-16 1990-11-05 Roussel Uclaf アザビシクロ化合物及びそれらの塩、それらの製造方法、それらを含有する製薬組成物並びにそれらの薬剤としての使用
GB8906100D0 (en) 1989-03-16 1989-04-26 Smith & Nephew Laminates
US5100396A (en) 1989-04-03 1992-03-31 Zamierowski David S Fluidic connection system and method
US5261893A (en) 1989-04-03 1993-11-16 Zamierowski David S Fastening system and method
US5527293A (en) 1989-04-03 1996-06-18 Kinetic Concepts, Inc. Fastening system and method
US4969880A (en) 1989-04-03 1990-11-13 Zamierowski David S Wound dressing and treatment method
US5266372A (en) 1989-04-24 1993-11-30 Nitto Denko Corporation Fixing tape
JP2719671B2 (ja) 1989-07-11 1998-02-25 日本ゼオン株式会社 創傷被覆材
US5358494A (en) 1989-07-11 1994-10-25 Svedman Paul Irrigation dressing
US5232453A (en) 1989-07-14 1993-08-03 E. R. Squibb & Sons, Inc. Catheter holder
GB2235877A (en) 1989-09-18 1991-03-20 Antonio Talluri Closed wound suction apparatus
US5423778A (en) 1989-12-14 1995-06-13 Elof Eriksson System and method for transplantation of cells
US5152757A (en) 1989-12-14 1992-10-06 Brigham And Women's Hospital System for diagnosis and treatment of wounds
US5270358A (en) 1989-12-28 1993-12-14 Minnesota Mining And Manufacturing Company Composite of a disperesed gel in an adhesive matrix
US6680113B1 (en) 1989-12-29 2004-01-20 3M Innovative Properties Company Multi-layered dressing
US5112323A (en) 1990-02-08 1992-05-12 Snyder Laboratories, Inc. Wound evacuator
US5134994A (en) 1990-02-12 1992-08-04 Say Sam L Field aspirator in a soft pack with externally mounted container
US4996128A (en) 1990-03-12 1991-02-26 Nova Manufacturing, Inc. Rechargeable battery
US5092858A (en) 1990-03-20 1992-03-03 Becton, Dickinson And Company Liquid gelling agent distributor device
US5092323A (en) 1990-06-29 1992-03-03 Hollister Incorporated Moisture-absorbing, site-revealing adhesive dressing
US5151314A (en) 1991-01-31 1992-09-29 Johnson & Johnson Medical, Inc. Three-layer laminated panel
AU641580B2 (en) 1991-02-28 1993-09-23 National Starch And Chemical Investment Holding Corporation Water vapor permeable pressure sensitive adhesive composition
US5180375A (en) 1991-05-02 1993-01-19 Feibus Miriam H Woven surgical drain and woven surgical sponge
US5149331A (en) 1991-05-03 1992-09-22 Ariel Ferdman Method and device for wound closure
US5653224A (en) 1991-06-10 1997-08-05 Creative Integration & Design, Inc. Nasal dilator with areas of adhesive engagement of varying strength
CA2071391C (en) 1991-07-29 1998-05-05 Thomas H. Gilman Vented wound dressing
US5387207A (en) 1991-08-12 1995-02-07 The Procter & Gamble Company Thin-unit-wet absorbent foam materials for aqueous body fluids and process for making same
SE502780C2 (sv) 1991-09-25 1996-01-08 Siemens Elema Ab Avfuktningsanordning
US5342329A (en) 1991-10-11 1994-08-30 Inmed Ltda. Portable disposable device for post-surgical suction
US5278100A (en) 1991-11-08 1994-01-11 Micron Technology, Inc. Chemical vapor deposition technique for depositing titanium silicide on semiconductor wafers
US5636643A (en) 1991-11-14 1997-06-10 Wake Forest University Wound treatment employing reduced pressure
US5645081A (en) 1991-11-14 1997-07-08 Wake Forest University Method of treating tissue damage and apparatus for same
US5279550A (en) 1991-12-19 1994-01-18 Gish Biomedical, Inc. Orthopedic autotransfusion system
US5585178A (en) 1991-12-31 1996-12-17 Minnesota Mining & Manufacturing Company Composite adhesive tape
AU4102493A (en) 1992-03-16 1994-11-08 Envirosurgical, Inc. Surgery plume filter device and method of filtering
US5167613A (en) 1992-03-23 1992-12-01 The Kendall Company Composite vented wound dressing
FR2690617B1 (fr) 1992-04-29 1994-06-24 Cbh Textile Pansement adhesif transparent.
US5678564A (en) 1992-08-07 1997-10-21 Bristol Myers Squibb Liquid removal system
US5419769A (en) 1992-10-23 1995-05-30 Smiths Industries Medical Systems, Inc. Suction systems
US5429590A (en) 1992-12-01 1995-07-04 Nitto Denko Corporation Medical water-absorptive polymer and dressing for wound and medical bandage using the same
EP0604103B1 (de) * 1992-12-15 1999-03-17 JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. Hydrogellaminat, Wundverbände und Verbundmaterialien und Verfahren zu deren Herstellung
DK169711B1 (da) 1993-01-15 1995-01-23 Coloplast As Hudpladeprodukt
DE4306478A1 (de) 1993-03-02 1994-09-08 Wolfgang Dr Wagner Drainagevorrichtung, insbesondere Pleuradrainagevorrichtung, und Drainageverfahren
DE4308649C2 (de) 1993-03-18 1995-11-16 Lohmann Gmbh & Co Kg Medizinisches Pflastermaterial sowie Verfahren zu seiner Herstellung und dessen Verwendung
US5342376A (en) 1993-05-03 1994-08-30 Dermagraphics, Inc. Inserting device for a barbed tissue connector
US6241747B1 (en) 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
NZ250994A (en) 1993-05-27 1995-09-26 Ndm Acquisition Corp Wound dressing comprising a hydrogel layer bound to a porous backing layer which is bound to a thin film layer by adhesive
US5344415A (en) 1993-06-15 1994-09-06 Deroyal Industries, Inc. Sterile system for dressing vascular access site
IE69360B1 (en) 1993-07-01 1996-09-04 Abbott Lab Gelling treatment for suction drainage system
US5437651A (en) 1993-09-01 1995-08-01 Research Medical, Inc. Medical suction apparatus
US5447492A (en) 1993-12-20 1995-09-05 New Dimensions In Medicine, Inc. External fixation dressing for accommodating a retaining pin
US5549584A (en) 1994-02-14 1996-08-27 The Kendall Company Apparatus for removing fluid from a wound
DE4406158A1 (de) 1994-02-25 1995-08-31 Rhein Chemie Rheinau Gmbh Polyurethanelastomere mit verminderter Gasdurchlässigkeit
ES2118004T3 (es) 1994-03-30 1998-09-01 Smith & Nephew Articulos medicos.
US6086995A (en) 1994-05-13 2000-07-11 Decora North America Self-wound self-adhesive surface covering material
US5556375A (en) 1994-06-16 1996-09-17 Hercules Incorporated Wound dressing having a fenestrated base layer
US5607388A (en) 1994-06-16 1997-03-04 Hercules Incorporated Multi-purpose wound dressing
US5664270A (en) 1994-07-19 1997-09-09 Kinetic Concepts, Inc. Patient interface system
DK0777504T3 (da) 1994-08-22 1999-06-28 Kinetic Concepts Inc Sårdræningsudstyr
US6228873B1 (en) 1994-12-09 2001-05-08 The Regents Of The University Of California Method for enhancing outflow of aqueous humor in treatment of glaucoma
SE503779C2 (sv) 1994-12-30 1996-09-02 Moelnlycke Ab Absorberande alster, omfattande ett mottagningsutrymme i ett lagringsskikt, som vid vätning ökar i omfång vinkelrätt mot alstrets yta samt absorptionskropp
DE69610819T2 (de) 1995-01-26 2002-11-21 Advanced Medical Solutions Ltd., Winsford Wundverband
DE29504378U1 (de) 1995-03-15 1995-09-14 MTG Medizinisch, technische Gerätebau GmbH, 66299 Friedrichsthal Elektronisch geregelte Niedervakuumpumpe für die Thorax- und Wunddrainage
US5634893A (en) 1995-04-24 1997-06-03 Haemonetics Corporation Autotransfusion apparatus
DE19517699C2 (de) 1995-05-13 1999-11-04 Wilhelm Fleischmann Vorrichtung zur Vakuumversiegelung einer Wunde
GB9523253D0 (en) 1995-11-14 1996-01-17 Mediscus Prod Ltd Portable wound treatment apparatus
US5736470A (en) 1996-06-25 1998-04-07 Omega Research, Inc. Pressure sensitive adhesive article and method of making
US5776119A (en) 1996-09-30 1998-07-07 Bilbo; Sharon C. Portable suction unit
GB9701178D0 (en) 1997-01-21 1997-03-12 Smith & Nephew Dressings
US5998561A (en) * 1997-03-11 1999-12-07 Jeneric/Pentron Incorporated Catalyst and composition for silicone dental impression materials
GB2324732B (en) 1997-05-02 2001-09-26 Johnson & Johnson Medical Absorbent wound dressings
NL1006457C2 (nl) 1997-07-03 1999-01-05 Polymedics N V Drainagesysteem toe te passen bij een open wond, hierbij gebruikt element voor het aanbrengen van een drainagebuis of -slang en werkwijze voor het toepassen van het drainagesysteem.
US6135116A (en) 1997-07-28 2000-10-24 Kci Licensing, Inc. Therapeutic method for treating ulcers
US6290685B1 (en) 1998-06-18 2001-09-18 3M Innovative Properties Company Microchanneled active fluid transport devices
GB9719520D0 (en) 1997-09-12 1997-11-19 Kci Medical Ltd Surgical drape and suction heads for wound treatment
AU755496B2 (en) 1997-09-12 2002-12-12 Kci Licensing, Inc. Surgical drape and suction head for wound treatment
US5919476A (en) 1997-09-29 1999-07-06 Pmt Corporation Reinforced gel sheeting for scar treatment
US6972141B1 (en) 1997-12-12 2005-12-06 3M Innovative Properties Company Removable adhesive tape laminate and separable fastener
US6071267A (en) 1998-02-06 2000-06-06 Kinetic Concepts, Inc. Medical patient fluid management interface system and method
US6458109B1 (en) 1998-08-07 2002-10-01 Hill-Rom Services, Inc. Wound treatment apparatus
US20030225355A1 (en) 1998-10-01 2003-12-04 Butler Charles E. Composite material for wound repair
US6488643B1 (en) 1998-10-08 2002-12-03 Kci Licensing, Inc. Wound healing foot wrap
US6736270B2 (en) 1998-10-30 2004-05-18 Varco I/P, Inc. Glued screens for shale shakers
US6627215B1 (en) 1998-12-30 2003-09-30 Oligos Etc. Inc. Devices for improved wound management
GB2348136B (en) 1999-03-24 2003-06-04 Johnson & Johnson Medical Ltd Wound dressings having low adherency
US6287316B1 (en) 1999-03-26 2001-09-11 Ethicon, Inc. Knitted surgical mesh
US7799004B2 (en) 2001-03-05 2010-09-21 Kci Licensing, Inc. Negative pressure wound treatment apparatus and infection identification system and method
US6856821B2 (en) 2000-05-26 2005-02-15 Kci Licensing, Inc. System for combined transcutaneous blood gas monitoring and vacuum assisted wound closure
US6695823B1 (en) 1999-04-09 2004-02-24 Kci Licensing, Inc. Wound therapy device
US6991643B2 (en) 2000-12-20 2006-01-31 Usgi Medical Inc. Multi-barbed device for retaining tissue in apposition and methods of use
US6495229B1 (en) 1999-09-17 2002-12-17 Avery Dennison Corporation Pattern coated adhesive article
US6638605B1 (en) 1999-11-16 2003-10-28 Allegiance Corporation Intermittently bonded nonwoven disposable surgical laminates
US6764462B2 (en) 2000-11-29 2004-07-20 Hill-Rom Services Inc. Wound treatment apparatus
KR20030009325A (ko) 1999-11-29 2003-01-29 힐-롬 서비시즈, 인크. 상처 치료 장치
EP1267763B1 (de) * 2000-01-03 2006-11-29 Biomed Sciences Inc. Wundverband, herstellungsverfahren und daraus erstellbare gegenstände
JP4330751B2 (ja) 2000-02-14 2009-09-16 富士フイルム株式会社 放射線画像取得方法および装置ならびにそのためのセル間隔検出方法および装置
US6566575B1 (en) 2000-02-15 2003-05-20 3M Innovative Properties Company Patterned absorbent article for wound dressing
US6548727B1 (en) 2000-02-17 2003-04-15 3M Innovative Properties Company Foam/film composite medical articles
EP1257313B1 (de) 2000-02-24 2004-05-12 Venetec International, Inc. Universelles katheterbefestigungssystem
ATE556683T1 (de) 2000-03-10 2012-05-15 3M Innovative Properties Co Verfahren zur herstellung von medizinischer verbänden mit unterschiedlichen klebern
KR20030027884A (ko) 2000-03-21 2003-04-07 킴벌리-클라크 월드와이드, 인크. 영구적으로 습윤성인 초흡수성 섬유
GB0011202D0 (en) 2000-05-09 2000-06-28 Kci Licensing Inc Abdominal wound dressing
BR0102116B1 (pt) 2000-05-10 2010-09-21 componente para um membro de circuito de respiração.
US7559324B2 (en) 2000-06-21 2009-07-14 Fisher & Paykel Healthcare Limited Conduit with heated wick
US6855135B2 (en) 2000-11-29 2005-02-15 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
US6685681B2 (en) 2000-11-29 2004-02-03 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
PT1343510E (pt) 2000-11-29 2010-07-15 Convatec Technologies Inc MATERIAIS ANTIMICROBIANOS ESTáVEIS ‚ LUZ
US6695867B2 (en) 2002-02-21 2004-02-24 Integrated Vascular Systems, Inc. Plunger apparatus and methods for delivering a closure device
US6541098B2 (en) 2000-12-22 2003-04-01 Avery Dennison Corporation Three-dimensional flexible adhesive film structures
US7329417B2 (en) 2001-02-08 2008-02-12 Coloplast A/S Medical dressing comprising an antimicrobial silver compound
WO2002070003A1 (en) 2001-02-14 2002-09-12 Genzyme Corporation Altered peptide ligands
US7070584B2 (en) 2001-02-20 2006-07-04 Kci Licensing, Inc. Biocompatible wound dressing
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US6540705B2 (en) 2001-02-22 2003-04-01 Core Products International, Inc. Ankle brace providing upper and lower ankle adjustment
US7236606B2 (en) 2001-03-07 2007-06-26 Harman International Industries, Incorporated Sound system having a HF horn coaxially aligned in the mouth of a midrange horn
US6695824B2 (en) 2001-04-16 2004-02-24 The United States Of America As Represented By The Secretary Of The Army Wound dressing system
US7645269B2 (en) 2001-04-30 2010-01-12 Kci Licensing, Inc. Gradient wound treatment system and method
AU2002316630A1 (en) 2001-07-12 2003-01-29 Hill-Rom Services, Inc. Control of vacuum level rate of change
GB2377939B (en) 2001-07-26 2005-04-20 Johnson & Johnson Medical Ltd Apertured sheet materials
US7004915B2 (en) 2001-08-24 2006-02-28 Kci Licensing, Inc. Negative pressure assisted tissue treatment system
SE524111C2 (sv) 2001-09-28 2004-06-29 Jan Otto Solem En metod och en anordning för organåterställning
US6787682B2 (en) 2001-11-05 2004-09-07 Hollister Incorporated Absorbent foam wound dressing
US6648862B2 (en) 2001-11-20 2003-11-18 Spheric Products, Ltd. Personally portable vacuum desiccator
GB2382305B (en) 2001-11-23 2004-12-15 Johnson & Johnson Medical Ltd Absorbent wound dressings containing a hydrogel layer
GB2382775B (en) * 2001-12-06 2005-05-25 Johnson & Johnson Medical Ltd Controlled release therapeutic wound dressings
DE60217925T2 (de) 2001-12-20 2007-11-08 Noble Fiber Technologies, Llc Metallisches silber enthaltende wundverbände
WO2003068283A2 (en) 2002-02-15 2003-08-21 Coloplast A/S A wound care device
US6693180B2 (en) 2002-04-04 2004-02-17 China Textile Institute Composite sponge wound dressing made of β-Chitin and Chitosan and method for producing the same
EP3424472A1 (de) 2002-04-10 2019-01-09 KCI Medical Resources Zugangsöffnungen in einem vakuumverband
US20030212357A1 (en) 2002-05-10 2003-11-13 Pace Edgar Alan Method and apparatus for treating wounds with oxygen and reduced pressure
US20030225347A1 (en) 2002-06-03 2003-12-04 Argenta Louis C. Directed tissue growth employing reduced pressure
US20050224978A1 (en) 2002-06-24 2005-10-13 Kohichiro Kawate Heat curable adhesive composition, article, semiconductor apparatus and method
US20040002676A1 (en) 2002-06-28 2004-01-01 Siegwart Kathleen Ann Adhesive bandage having a selectively placed layer
DE10230121A1 (de) 2002-07-04 2004-02-05 Basf Ag Verfahren zur Herstellung von diskreten Mustern klebender Beschichtungen auf einem Substrat
US7846141B2 (en) 2002-09-03 2010-12-07 Bluesky Medical Group Incorporated Reduced pressure treatment system
PT1536845E (pt) 2002-09-11 2007-06-01 Johnson & Johnson Medical Ltd Materiais de penso compreendendo complexos de polissacarídeos aniónicos com prata
GB2392836B (en) 2002-09-11 2005-05-25 Johnson & Johnson Medical Ltd Wound dressings for the treatment of wound infection
US6979324B2 (en) 2002-09-13 2005-12-27 Neogen Technologies, Inc. Closed wound drainage system
US7520872B2 (en) 2002-09-13 2009-04-21 Neogen Technologies, Inc. Closed wound drainage system
US7815616B2 (en) 2002-09-16 2010-10-19 Boehringer Technologies, L.P. Device for treating a wound
GB2393655B (en) 2002-09-27 2005-08-24 Johnson & Johnson Medical Ltd Wound treatment device
US7119247B2 (en) 2002-10-22 2006-10-10 George Medical, Llc Dressing and a method for making and applying a dressing
GB0224986D0 (en) 2002-10-28 2002-12-04 Smith & Nephew Apparatus
US20040219337A1 (en) 2002-11-25 2004-11-04 Kappler, Inc. Breathable blood and viral barrier fabric
US7612248B2 (en) 2002-12-19 2009-11-03 3M Innovative Properties Company Absorbent medical articles
CA2510977C (en) * 2002-12-31 2012-09-18 Ossur Hf Wound dressing comprising an absorbent core with a plurality of receptacles formed therein
US6951553B2 (en) 2002-12-31 2005-10-04 Kci Licensing, Inc Tissue closure treatment system and method with externally-applied patient interface
US7976519B2 (en) 2002-12-31 2011-07-12 Kci Licensing, Inc. Externally-applied patient interface system and method
US7322971B2 (en) 2003-02-07 2008-01-29 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Surgical drain with sensors for monitoring internal tissue condition by transmittance
US7351217B2 (en) 2003-05-23 2008-04-01 Yvette Scherpenborg Thermal compressive aerating bandage and methods of use relating to same
SE526906C2 (sv) * 2003-06-10 2005-11-15 Moelnlycke Health Care Ab Metod att anbringa ett skyddsskikt på hud innehållande en högviskös silikonkomposition
IES20030443A2 (en) 2003-06-16 2004-12-01 Fraudhalt Ltd A method and apparatus for determining if an optical disk originated from a valid source
AU2004248898B2 (en) 2003-06-23 2010-03-18 Beiersdorf Ag Antimicrobial wounddressing
US20050158539A1 (en) 2003-06-25 2005-07-21 Andover Coated Products, Inc. Pressure-sensitive adhesive tapes
US20060154546A1 (en) 2003-06-25 2006-07-13 Andover Coated Products, Inc. Air permeable pressure-sensitive adhesive tapes
US20050034731A1 (en) 2003-08-13 2005-02-17 Rousseau Robert A. Surgical wound closure device
US7942866B2 (en) 2003-08-28 2011-05-17 Boehringer Technologies, L.P. Device for treating a wound
US20050054998A1 (en) 2003-09-05 2005-03-10 Poccia John F. Absorbent article
US20050065484A1 (en) 2003-09-10 2005-03-24 Watson Richard L. Wound healing apparatus with bioabsorbable material and suction tubes
DK1675536T3 (en) 2003-09-17 2016-04-18 Bsn Medical Gmbh WOUND COMPOUND AND PROCEDURE FOR PREPARING IT
US20050214376A1 (en) 2003-10-21 2005-09-29 Marie-Pierre Faure Hydrogel-containing medical articles and methods of using and making the same
US20060083776A1 (en) 2003-10-27 2006-04-20 Bott Richard R Preparations for topical application and methods of delivering an active agent to a substrate
KR101105081B1 (ko) 2003-12-23 2012-01-16 헴콘 메디컬 테크놀로지스, 인크. 키토산과 같은 친수성 중합체 스폰지 구조체로부터 형성된조직 드레싱 조립체, 시스템 및 방법
US7137390B2 (en) 2004-01-23 2006-11-21 Ric Investments, Llc. Liquid absorbing filter assembly and system using same
US20050163978A1 (en) 2004-01-27 2005-07-28 Esben Strobech Article having a surface showing adhesive properties
US8062272B2 (en) 2004-05-21 2011-11-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
GB0409293D0 (en) 2004-04-27 2004-06-02 Smith & Nephew Apparatus with flow stress
US20050277860A1 (en) 2004-06-14 2005-12-15 Jentec, Inc. Extended stay-on wound dressing
GB2415382A (en) 2004-06-21 2005-12-28 Johnson & Johnson Medical Ltd Wound dressings for vacuum therapy
DE202004017052U1 (de) 2004-11-02 2005-06-09 Riesinger, Birgit Vorrichtung zur Wundbehandlung unter Einsatz von Unterdruck
DE202004018245U1 (de) 2004-11-24 2005-07-07 Riesinger, Birgit Drainagevorrichtung zur Wundbehandlung unter Einsatz von Unterdruck
US7161056B2 (en) * 2005-01-28 2007-01-09 Ossur Hf Wound dressing and method for manufacturing the same
US20060188558A1 (en) * 2005-02-18 2006-08-24 Mylan Technologies, Inc. Transdermal systems having control delivery system
GB2425487A (en) 2005-04-26 2006-11-01 Dow Corning Wound dressing and method of preparation
US8372040B2 (en) 2005-05-24 2013-02-12 Chrono Therapeutics, Inc. Portable drug delivery device including a detachable and replaceable administration or dosing element
CN101257877B (zh) 2005-06-29 2013-07-17 应用纸巾技术有限公司 伤口敷裹
US20070027414A1 (en) 2005-07-28 2007-02-01 Integra Lifesciences Corporation Laminar construction negative pressure wound dressing including bioabsorbable material
EP1924854B1 (de) 2005-08-16 2016-04-13 Oridion Medical 1987 Ltd. Atemprobennahmevorrichtung und verfahren zur verwendung davon
CA2619929A1 (en) 2005-09-06 2007-03-15 Tyco Healthcare Group Lp Self contained wound dressing with micropump
JP5005916B2 (ja) 2005-12-09 2012-08-22 スリーエム イノベイティブ プロパティズ カンパニー 皮膚粘着剤用剥離剤組成物
DE202005019670U1 (de) 2005-12-14 2006-04-27 Riesinger, Birgit Wundbehandlungsvorrichtung mit elastisch verformbarem Unterdruckerzeugungselement
DE202006007877U1 (de) 2006-01-25 2006-07-27 Riesinger, Birgit Vorgefertigte Wundauflage mit Superabsorber
CA2635697A1 (en) 2006-02-02 2007-08-09 Coloplast A/S A suction system
EP3348290B1 (de) 2006-02-06 2019-11-20 KCI Licensing, Inc. Systeme zur verbesserten verbindung an wundverbände in verbindung mit systemen zur wundbehandlung mit vermindertem druck
JP2007254515A (ja) 2006-03-22 2007-10-04 Lintec Corp 皮膚貼付用粘着シート
GB0606661D0 (en) 2006-04-03 2006-05-10 Brightwake Ltd Improvements relating to dressings
DE102006017194B4 (de) 2006-04-12 2010-11-04 Birgit Riesinger Flüssigkeitsdurchlässiger Primärverband
US7615036B2 (en) 2006-05-11 2009-11-10 Kalypto Medical, Inc. Device and method for wound therapy
US7779625B2 (en) 2006-05-11 2010-08-24 Kalypto Medical, Inc. Device and method for wound therapy
GB2439928A (en) 2006-07-13 2008-01-16 Ethicon Inc Hydrogel wound dressings exhibiting reduced fiber losses
US20090326488A1 (en) 2006-07-24 2009-12-31 Klaus Budig Canister, Suction Device and System For Vacuum Treatment Securing a Fixed Treatment Pressure
ATE456383T1 (de) 2006-09-28 2010-02-15 Tyco Healthcare Tragbares wundtherapiesystem
DE102006047041A1 (de) 2006-10-02 2008-04-10 Birgit Riesinger Flächenhafter Absorptionskörper
SE0602064L (sv) 2006-10-03 2008-04-04 Moelnlycke Health Care Ab Sårförband med tryckfördelande slangingång
WO2008082444A2 (en) 2006-10-03 2008-07-10 Arsenal Medical, Inc. Articles and methods for tissue repair
EP2079507B1 (de) 2006-10-13 2016-11-23 KCI Licensing, Inc. Unterdruckabgabesystem mit manuell betätigter pumpe zur behandlung leichter wunden
SE0602303L (sv) 2006-11-01 2008-05-02 Moelnlycke Health Care Ab Operationslakan med lättböjlig kant och förstyvande kantskikt
DE202007019572U1 (de) 2006-12-06 2013-12-02 Weinmann Geräte für Medizin GmbH + Co. KG Atemmaske mit einem Füllkörper
US8267908B2 (en) 2007-02-09 2012-09-18 Kci Licensing, Inc. Delivery tube, system, and method for storing liquid from a tissue site
CN101605519B (zh) 2007-02-09 2013-05-22 凯希特许有限公司 用于局部减压的透气性界面系统
MX2009008397A (es) 2007-02-09 2009-10-28 Kci Licensing Inc Sistema y metodo para administrar presion reducida en un sitio de tejido.
WO2008104609A1 (en) 2007-03-01 2008-09-04 Coloplast A/S Pressure-distributing elements for use with negative pressure therapy
EP3513820A1 (de) 2007-03-14 2019-07-24 The Board of Trustees of the Leland Stanford University Vorrichtungen zur anwendung einer unterdrucktherapie
US8083712B2 (en) 2007-03-20 2011-12-27 Neogen Technologies, Inc. Flat-hose assembly for wound drainage system
EP2142152A1 (de) 2007-04-26 2010-01-13 Isense Corporation Haftverband
DE102008020553A1 (de) 2007-04-29 2008-10-30 Iskia Gmbh & Co.Kg Flachdrainage für Wundbehandlungen
CA2688167C (en) 2007-05-24 2017-05-16 Applied Tissue Technologies Llc Wound treatment device employing negative pressure
GB0710846D0 (en) 2007-06-06 2007-07-18 Bristol Myers Squibb Co A wound dressing
SE531259C2 (sv) 2007-06-27 2009-02-03 Moelnlycke Health Care Ab Anordning för behandling av sår med reducerat tryck
US20090025724A1 (en) 2007-07-16 2009-01-29 Herron Jr Roy Howard System for removal of water from a hose and the hygroscopic hose utilized
GB2452720A (en) 2007-09-11 2009-03-18 Ethicon Inc Wound dressing with an antimicrobial absorbent layer and an apertured cover sheet
US20090088719A1 (en) 2007-09-27 2009-04-02 Tyco Healthcare Retail Service Ag Absorbent article having integral stretch panels and methods for making the same
DK2214611T3 (en) 2007-11-21 2019-03-25 Smith & Nephew Wound dressing
US8808274B2 (en) 2007-11-21 2014-08-19 Smith & Nephew Plc Wound dressing
US20130096518A1 (en) 2007-12-06 2013-04-18 Smith & Nephew Plc Wound filling apparatuses and methods
GB2455962A (en) 2007-12-24 2009-07-01 Ethicon Inc Reinforced adhesive backing sheet, for plaster
US8377017B2 (en) 2008-01-03 2013-02-19 Kci Licensing, Inc. Low-profile reduced pressure treatment system
US8460258B2 (en) 2008-01-08 2013-06-11 Southeastern Medical Technologies, Llc Methods and apparatuses for the treatment of wounds with pressures altered from atmospheric
EP2244746B2 (de) 2008-02-27 2019-01-02 Aplion Medical Corporation Wundverbandvorrichtung mit gleichmässiger verteilung
US8449508B2 (en) 2008-03-05 2013-05-28 Kci Licensing, Inc. Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
CA2716769C (en) 2008-03-05 2016-08-16 Kci Licensing, Inc. Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US8298200B2 (en) 2009-06-01 2012-10-30 Tyco Healthcare Group Lp System for providing continual drainage in negative pressure wound therapy
US20090234306A1 (en) 2008-03-13 2009-09-17 Tyco Healthcare Group Lp Vacuum wound therapy wound dressing with variable performance zones
BRPI0906527A2 (pt) 2008-04-04 2016-09-06 3Mm Innovative Properties Company aparelho para aplicação de bandagens em ferimentos e bandagem médica
SE533170C2 (sv) 2008-04-09 2010-07-13 Moelnlycke Health Care Ab Anordning för att behandla sår med undertryck
US8048046B2 (en) 2008-05-21 2011-11-01 Tyco Healthcare Group Lp Wound therapy system with housing and canister support
US8545469B2 (en) 2008-08-05 2013-10-01 Mölnlycke Health Care Ab Component for securing attachment of a medical device to skin
US20110171480A1 (en) 2008-09-16 2011-07-14 Asahi Rubber Inc. Three-dimensional silicone-rubber bonded object
KR20110083692A (ko) 2008-10-29 2011-07-20 케이씨아이 라이센싱 인코포레이티드 모듈식 감압 상처 폐쇄 시스템 및 방법
EP3388093B1 (de) 2008-11-14 2020-05-20 KCI Licensing, Inc. Flüssigkeitsbeutel, system und verfahren zur aufbewahrung von flüssigkeit aus einer gewebestelle
RU2011113997A (ru) 2008-11-19 2012-12-27 КейСиАй ЛАЙСЕНЗИНГ, ИНК. Динамические системы и способы терапии пониженным давлением
GB0821702D0 (en) 2008-11-28 2008-12-31 Brightwake Ltd Process
US8162907B2 (en) 2009-01-20 2012-04-24 Tyco Healthcare Group Lp Method and apparatus for bridging from a dressing in negative pressure wound therapy
US9067035B2 (en) 2009-03-03 2015-06-30 Oridion Medical (1987) Ltd. Drying substances, preparation and use thereof
CN102803423A (zh) 2009-04-17 2012-11-28 3M创新有限公司 有机硅凝胶粘合剂构造
EP2433594B1 (de) 2009-04-24 2016-06-01 Alcare Co., Ltd. Wundpflegeprodukt und verfahren zu dessen herstellung
CN102782069B (zh) 2009-04-27 2014-03-19 艾利丹尼森公司 用于根据需要运送和脱粘的系统、方法和材料
US20100324516A1 (en) 2009-06-18 2010-12-23 Tyco Healthcare Group Lp Apparatus for Vacuum Bridging and/or Exudate Collection
US8469936B2 (en) 2009-07-15 2013-06-25 Kci Licensing, Inc. Reduced-pressure dressings, systems, and methods employing desolidifying barrier layers
CA2773915A1 (en) 2009-09-17 2011-04-14 Zipline Medical, Inc. Rapid closing surgical closure device
US8529526B2 (en) 2009-10-20 2013-09-10 Kci Licensing, Inc. Dressing reduced-pressure indicators, systems, and methods
US8721606B2 (en) 2010-03-11 2014-05-13 Kci Licensing, Inc. Dressings, systems, and methods for treating a tissue site
US8814842B2 (en) 2010-03-16 2014-08-26 Kci Licensing, Inc. Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US20110257617A1 (en) 2010-04-02 2011-10-20 Franklin Amie B Therapeutic Diffusion Hydrocolloid Wound Dressings
JP2013524275A (ja) * 2010-04-03 2013-06-17 ドシ，プラフル 薬剤を含む医療機器、その製造方法とその使用方法
DE102010014010A1 (de) 2010-04-03 2011-10-06 Birgit Riesinger Wundpflegeartikel angepasst an unterschiedliche Durchflussgeschwindigkeiten des Wundexsudats
EP2578193B1 (de) 2010-06-01 2016-03-23 Zuiko Corporation Oberflächenfolie für einen wundverband und wundverband
WO2011162862A1 (en) 2010-06-23 2011-12-29 Convatec Technologies Inc. Wound dressing
US9265665B2 (en) 2010-07-19 2016-02-23 Kci Licensing, Inc. Inflatable off-loading wound dressing assemblies, systems, and methods
GB201014705D0 (en) * 2010-09-03 2010-10-20 Systagenix Wound Man Ip Co Bv Silicone gel-coated wound dressing
US8986269B2 (en) 2010-11-11 2015-03-24 Ulcerx Medical Inc. Wound leakage vacuum collection device
GB2488749A (en) * 2011-01-31 2012-09-12 Systagenix Wound Man Ip Co Bv Laminated silicone coated wound dressing
US9107990B2 (en) 2011-02-14 2015-08-18 Kci Licensing, Inc. Reduced-pressure dressings, systems, and methods for use with linear wounds
US20120258271A1 (en) 2011-04-08 2012-10-11 Pointil Systems Inc. Methods for reducing tack of pressure-sensitive adhesive
GB201106491D0 (en) 2011-04-15 2011-06-01 Systagenix Wound Man Ip Co Bv Patterened silicone coating
FR2974005B1 (fr) 2011-04-15 2014-05-02 Urgo Lab Pansement adhesif mince tres absorbant, ses utilisations pour le traitement des plaies chroniques
ES2598231T3 (es) 2011-04-21 2017-01-26 Smith & Nephew Plc Gestión de obstrucciones
GB201108229D0 (en) 2011-05-17 2011-06-29 Smith & Nephew Tissue healing
WO2013009239A1 (en) 2011-07-08 2013-01-17 Mölnlycke Health Care Ab Self-adhesive wound care product
US9023012B2 (en) 2011-07-26 2015-05-05 Kci Licensing, Inc. Systems and methods for treating a tissue site with reduced pressure involving a reduced-pressure interface having a multi-lumen conduit for contacting a manifold
CA2844663C (en) 2011-09-14 2019-09-24 Kci Licensing, Inc. Reduced-pressure systems and methods employing a leak-detection member
EP3351665B1 (de) 2011-11-01 2020-06-03 Brightwake Limited Gelierende wundverbände
EP3005997B1 (de) 2011-12-16 2024-06-26 Solventum Intellectual Properties Company Ablösbare medizinische abdecktücher
JP2015505706A (ja) 2011-12-16 2015-02-26 ケーシーアイ ライセンシング インコーポレイテッド 切り替え可能ドレープを用いるシーリングシステムおよび方法
CA2865518C (en) 2012-03-12 2020-01-28 Bostik Sa Breathable self-adhesive articles
CA2880143C (en) 2012-08-01 2024-04-23 Smith & Nephew Plc Wound dressing
US9623159B2 (en) 2012-08-03 2017-04-18 Kci Licensing, Inc. Interfaces, systems, and methods for use in reduced pressure tissue treatment
US20150202354A1 (en) 2012-09-04 2015-07-23 Integrated Healing Technolgies, LLC Wound Dressing
WO2014113253A1 (en) 2013-01-16 2014-07-24 Kci Licensing, Inc. Dressing with asymmetric absorbent core for negative pressure wound therapy
EP4018985B1 (de) 2013-03-14 2024-10-02 Solventum Intellectual Properties Company Saugfähiger wundverband mit einem hybriden abdecktuch
BR112015022444A2 (pt) 2013-03-15 2017-07-18 Smith & Nephew curativo de feridas vedante e uso do mesmo
GB2512841B (en) 2013-04-08 2020-07-15 Brightwake Ltd Absorbent wound dressings
EP3062833B1 (de) 2013-10-30 2019-04-17 KCI Licensing, Inc. Absorbierende leitung und system
CA2940730C (en) 2014-02-28 2022-07-26 Kci Licensing, Inc. Hybrid drape having a gel-coated perforated mesh

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1280631A (en) 1968-07-09 1972-07-05 Smith & Nephew Adhesive materials
GB1301101A (en) 1969-01-08 1972-12-29 Secr Defence Improvements in the manufacture of carbon
EP0053936A2 (de) 1980-12-08 1982-06-16 Johnson & Johnson Products Inc. Chirurgische Verbände
GB2127389A (en) 1982-09-13 1984-04-11 Charcoal Cloth Ltd Activated carbon products and their manufacture
EP0117632A2 (de) 1983-01-27 1984-09-05 Johnson & Johnson Products Inc. Filmheftpflaster
US4871611A (en) * 1985-11-15 1989-10-03 Mead Release Products, Inc. Breathable backing or release liner and process for forming the same
WO1987005206A1 (en) 1986-03-10 1987-09-11 Mölnlycke AB Wound dressing
EP0251810A2 (de) 1986-07-04 1988-01-07 JOHNSON & JOHNSON Wundverband
EP0342950A2 (de) 1988-05-18 1989-11-23 SMITH & NEPHEW plc Wundverband
EP0541391A1 (de) 1991-11-07 1993-05-12 JOHNSON & JOHNSON MEDICAL, INC. Verfahren zur Herstellung von Polyurethan-Schaumstoff
WO1993019710A1 (en) 1992-03-30 1993-10-14 Mölnlycke AB An absorbent wound dressing
EP1002846A1 (de) * 1998-11-19 2000-05-24 Minnesota Mining And Manufacturing Company Klebeband für ein Windelverschlusssystem
US20050113732A1 (en) * 2001-04-19 2005-05-26 Roger Lawry Scar tissue treatment bandage and method
WO2003053584A2 (en) 2001-12-20 2003-07-03 Board Of Regents, The University Of Texas System Dielectric gate and methods for fluid injection and control
WO2010005654A2 (en) 2008-07-03 2010-01-14 Chevron U.S.A. Inc. System and method for separating a trace element from a liquid hydrocarbon feed

Cited By (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10086107B2 (en) 2006-04-03 2018-10-02 Brightwake Limited Adhesive laminates and applications thereof
US10299966B2 (en) 2007-12-24 2019-05-28 Kci Usa, Inc. Reinforced adhesive backing sheet
US12097094B2 (en) 2008-03-05 2024-09-24 Solventum Intellectual Properties Company Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US11020516B2 (en) 2008-03-05 2021-06-01 Kci Licensing, Inc. Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US10010656B2 (en) 2008-03-05 2018-07-03 Kci Licensing, Inc. Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US11400204B2 (en) 2010-03-16 2022-08-02 Kci Licensing, Inc. Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US20140330227A1 (en) 2010-03-16 2014-11-06 Kci Licensing, Inc. Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US10279088B2 (en) 2010-03-16 2019-05-07 Kci Licensing, Inc. Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US10568767B2 (en) 2011-01-31 2020-02-25 Kci Usa, Inc. Silicone wound dressing laminate and method for making the same
US10357406B2 (en) 2011-04-15 2019-07-23 Kci Usa, Inc. Patterned silicone coating
US9393158B2 (en) 2011-08-25 2016-07-19 Brightwake Limited Non-adherent wound dressing
GB2493960A (en) * 2011-08-25 2013-02-27 Brightwake Ltd Wound dressing comprising perforated sheet impregnated with silicone gel
GB2493960B (en) * 2011-08-25 2013-09-18 Brightwake Ltd Non-adherent wound dressing
US10940047B2 (en) 2011-12-16 2021-03-09 Kci Licensing, Inc. Sealing systems and methods employing a hybrid switchable drape
US9861532B2 (en) 2011-12-16 2018-01-09 Kci Licensing, Inc. Releasable medical drapes
US11969318B2 (en) 2011-12-16 2024-04-30 Solventum Intellectual Properties Company Releasable medical drapes
US11944520B2 (en) 2011-12-16 2024-04-02 3M Innovative Properties Company Sealing systems and methods employing a hybrid switchable drape
US10945889B2 (en) 2011-12-16 2021-03-16 Kci Licensing, Inc. Releasable medical drapes
USD733896S1 (en) 2012-05-04 2015-07-07 Genadyne Biotechnologies, Inc. Abdominal dressing
US10842707B2 (en) 2012-11-16 2020-11-24 Kci Licensing, Inc. Medical drape with pattern adhesive layers and method of manufacturing same
US11839529B2 (en) 2012-11-16 2023-12-12 Kci Licensing, Inc. Medical drape with pattern adhesive layers and method of manufacturing same
US11395785B2 (en) 2012-11-16 2022-07-26 Kci Licensing, Inc. Medical drape with pattern adhesive layers and method of manufacturing same
US11141318B2 (en) 2012-12-18 2021-10-12 KCl USA, INC. Wound dressing with adhesive margin
US10271995B2 (en) 2012-12-18 2019-04-30 Kci Usa, Inc. Wound dressing with adhesive margin
AU2013365843B2 (en) * 2012-12-18 2018-09-13 Systagenix Wound Management Ip Co. B.V. Wound dressing with adhesive margin
EP3092991A1 (de) * 2012-12-18 2016-11-16 Systagenix Wound Management IP Co. BV. Wundverband mit klebstoffrand
JP2016506283A (ja) * 2013-01-09 2016-03-03 ベーエスエヌ・メディカル・ゲーエムベーハーＢＳＮ ｍｅｄｉｃａｌ ＧｍｂＨ シリコーンコーティングを有する液体浸透性一次包帯剤
CN105007871A (zh) * 2013-01-09 2015-10-28 Bsn医疗有限公司 具有有机硅涂层的透液性主要敷料
AU2014204880B2 (en) * 2013-01-09 2018-03-22 Bsn Medical Gmbh Liquid-permeable primary dressing with a silicone coating
US10603219B2 (en) 2013-01-09 2020-03-31 Bsn Medical Gmbh Liquid-permeable primary dressing with a silicone coating
WO2014108476A1 (de) * 2013-01-09 2014-07-17 Birgit Riesinger Flüssigkeitsdurchlässiger primärverband mit einer silikonbeschichtung
US10117978B2 (en) 2013-08-26 2018-11-06 Kci Licensing, Inc. Dressing interface with moisture controlling feature and sealing function
US10946124B2 (en) 2013-10-28 2021-03-16 Kci Licensing, Inc. Hybrid sealing tape
US10398814B2 (en) 2013-10-30 2019-09-03 Kci Licensing, Inc. Condensate absorbing and dissipating system
US10849792B2 (en) 2013-10-30 2020-12-01 Kci Licensing, Inc. Absorbent conduit and system
US10940046B2 (en) 2013-10-30 2021-03-09 Kci Licensing, Inc. Dressing with sealing and retention interface
US11793923B2 (en) 2013-10-30 2023-10-24 Kci Licensing, Inc. Dressing with differentially sized perforations
US9925092B2 (en) 2013-10-30 2018-03-27 Kci Licensing, Inc. Absorbent conduit and system
US10967109B2 (en) 2013-10-30 2021-04-06 Kci Licensing, Inc. Dressing with differentially sized perforations
US11744740B2 (en) 2013-10-30 2023-09-05 Kci Licensing, Inc. Dressing with sealing and retention interface
US9956120B2 (en) 2013-10-30 2018-05-01 Kci Licensing, Inc. Dressing with sealing and retention interface
US20150119831A1 (en) 2013-10-30 2015-04-30 Kci Licensing, Inc. Condensate absorbing and dissipating system
US10016544B2 (en) 2013-10-30 2018-07-10 Kci Licensing, Inc. Dressing with differentially sized perforations
US11964095B2 (en) 2013-10-30 2024-04-23 Solventum Intellectual Properties Company Condensate absorbing and dissipating system
US11154650B2 (en) 2013-10-30 2021-10-26 Kci Licensing, Inc. Condensate absorbing and dissipating system
US10632020B2 (en) 2014-02-28 2020-04-28 Kci Licensing, Inc. Hybrid drape having a gel-coated perforated mesh
US11026844B2 (en) 2014-03-03 2021-06-08 Kci Licensing, Inc. Low profile flexible pressure transmission conduit
US10226566B2 (en) 2014-04-23 2019-03-12 Genadyne Biotechnologies, Inc. System and process for removing bodily fluids from a body opening
US10406266B2 (en) 2014-05-02 2019-09-10 Kci Licensing, Inc. Fluid storage devices, systems, and methods
US10561534B2 (en) 2014-06-05 2020-02-18 Kci Licensing, Inc. Dressing with fluid acquisition and distribution characteristics
US11957546B2 (en) 2014-06-05 2024-04-16 3M Innovative Properties Company Dressing with fluid acquisition and distribution characteristics
US20160166726A1 (en) * 2014-12-11 2016-06-16 Gergonne Sas Non adherent healing interface and associated compress and dressing
US10398604B2 (en) 2014-12-17 2019-09-03 Kci Licensing, Inc. Dressing with offloading capability
US11246975B2 (en) 2015-05-08 2022-02-15 Kci Licensing, Inc. Low acuity dressing with integral pump
US11096830B2 (en) 2015-09-01 2021-08-24 Kci Licensing, Inc. Dressing with increased apposition force
US11950984B2 (en) 2015-09-01 2024-04-09 Solventum Intellectual Properties Company Dressing with increased apposition force
US10973694B2 (en) 2015-09-17 2021-04-13 Kci Licensing, Inc. Hybrid silicone and acrylic adhesive cover for use with wound treatment
US11944521B2 (en) 2015-11-13 2024-04-02 First Water Limited Compositions for application to wounds
WO2019027401A3 (en) * 2017-05-05 2019-03-21 T.C. Istanbul Medipol Universitesi DRESSING ARTICLE

Also Published As

Publication number Publication date
GB201101662D0 (en) 2011-03-16
GB2488749A (en) 2012-09-12
US20200146900A1 (en) 2020-05-14
US10568767B2 (en) 2020-02-25
EP2670369A1 (de) 2013-12-11
EP2670369B1 (de) 2017-06-28
US20140058309A1 (en) 2014-02-27

Similar Documents

Publication Publication Date Title
US20200146900A1 (en) Silicone wound dressing laminate and method for making the same
US20210401630A1 (en) Wound dressing with adhesive margin
US11432968B2 (en) Silicone gel-coated wound dressing
US20190298582A1 (en) Patterned silicone coating
JP5767235B2 (ja) 医療用物品及び不混和性材料を用いる製造方法
US20170231821A1 (en) Silicone wound contact layer with silver

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12705381

Country of ref document: EP

Kind code of ref document: A1

REEP Request for entry into the european phase

Ref document number: 2012705381

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2012705381

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 13982650

Country of ref document: US