WO2011040141A1 - 脂溶性ビタミン含有組成物 - Google Patents
脂溶性ビタミン含有組成物 Download PDFInfo
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- WO2011040141A1 WO2011040141A1 PCT/JP2010/064065 JP2010064065W WO2011040141A1 WO 2011040141 A1 WO2011040141 A1 WO 2011040141A1 JP 2010064065 W JP2010064065 W JP 2010064065W WO 2011040141 A1 WO2011040141 A1 WO 2011040141A1
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- fat
- soluble vitamin
- vitamin
- containing composition
- soluble
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Definitions
- the present invention relates to a fat-soluble vitamin-containing composition with improved stability.
- fat-soluble vitamins have been attracting attention as an effective ingredient for anti-aging, beauty effects, health maintenance and the like, and have been used for health foods, functional foods, functional beverages, supplements, pharmaceuticals, cosmetics and the like.
- fat-soluble vitamins are very sensitive and unstable to oxygen, light, heat, pH, metal ions, etc., so that fat-soluble vitamins are easily degraded during storage, resulting in a decrease in fat-soluble vitamin content. Therefore, a highly stable fat-soluble vitamin-containing composition has been demanded.
- a conventional technique for improving the stability of fat-soluble vitamins is a fat-soluble vitamin-containing food or drink comprising an oil-in-water emulsion, wherein the oil-in-water emulsion contains an internal oil phase part and an aqueous phase part.
- the external oil phase part, and the internal oil phase part contains fat-soluble vitamins (see Patent Document 1), stabilized oil-soluble vitamin-containing composition containing carotenoids (see Patent Document 2) ), A composition having improved photostability obtained by blending one or more substances selected from yellow and red colorants into a photolabile fat-soluble drug (see Patent Document 3), tocopherol succinate or the like Vitamin preparations (see Patent Document 4) comprising a salt, vitamin B1 or a salt thereof and a basic inorganic compound having a specific volume of about 3 mL / g or more have been disclosed. The effect of improving stability of the emissions is further preferred method not enough has been demanded.
- An object of the present invention is to provide a fat-soluble vitamin-containing composition with improved stability.
- a fat-soluble vitamin-containing composition characterized by containing a fat-soluble vitamin and potassium carbonate; 2.
- a food or drink comprising the fat-soluble vitamin-containing composition according to 1 above, 3.
- a fat-soluble vitamin-containing composition containing 0.005 to 30 parts by mass of potassium carbonate with respect to 100 parts by mass of the fat-soluble vitamin, and a food or drink containing the fat-soluble vitamin-containing composition.
- a method for stabilizing a fat-soluble vitamin-containing composition comprising adding 0.005 to 30 parts by mass of potassium carbonate to 100 parts by mass of a fat-soluble vitamin.
- the fat-soluble vitamin-containing composition of the present invention is stable, suppresses a decrease in the content of the fat-soluble vitamin, has little change over time in quality, and even if the fat-soluble vitamin-containing composition is added to food and drink, Reduction in the content of is suppressed.
- the fat-soluble vitamin used in the present invention examples include vitamin A, vitamin E, vitamin D, vitamin K, ubiquinone, and derivatives thereof.
- Specific examples of the fat-soluble vitamin include, for example, vitamin A such as retinol, 3-dehydroretinol, retinal, 3-dehydroretinal, retinoic acid, 3-dehydroretinoic acid and derivatives thereof such as acetate ester or palmitate ester.
- Vitamin Ds such as ergocalciphenol, cholecalciphenol and derivatives thereof such as sulfate; ⁇ -tocopherol, ⁇ -tocopherol, ⁇ -tocopherol, ⁇ -tocopherol, ⁇ -tocotrienol, ⁇ -tocotrienol, ⁇ -tocotrienol, Vitamin E such as ⁇ -tocotrienol and derivatives thereof such as acetate, nicotinate or phosphate; vitamin K such as phylloquinone, menaquinone and menadione; ubiquinone And ubiquinone having 1 to 12 isoprene residues.
- These fat-soluble vitamins can be used alone or in combination of two or more.
- the fat-soluble vitamin used in the present invention is obtained by extraction and purification from a natural product by a known method, obtained by chemical synthesis by a known method, and further obtained by fermentation using a microorganism or the like. Any of these may be used.
- the fat-soluble vitamins used in the present invention may be those added with edible fats and oils in order to adjust the concentration of the fat-soluble vitamins.
- the edible fats and oils are not particularly limited as long as they are edible fats and oils, for example, safflower oil, grape oil, soybean oil, sunflower oil, wheat germ oil, corn oil, cottonseed oil, sesame oil, rapeseed oil, sesame oil, Hydrogenation of vegetable oils such as peanut oil, olive oil, medium chain fatty acid triglycerides (MCT), palm oil, palm kernel oil, palm oil, animal fats such as beef tallow, lard, milk fat and fish oil, and these animal and vegetable oils Examples include transesterified oils and fats.
- the said edible fats and oils can combine 1 type, or 2 or more types.
- the fat-soluble vitamin when obtained by extraction and purification from a natural product, it may contain edible fats and oils derived from the extraction raw material.
- the potassium carbonate used in the present invention is not particularly limited in shape and purity, and commercially available products can be used.
- a preferred form of potassium carbonate is a form that increases the contact area with the fat-soluble vitamin.
- the amount of potassium carbonate used in the present invention is preferably about 0.005 to 30 parts by mass, more preferably 0.01 to 10 parts by mass with respect to 100 parts by mass of the fat-soluble vitamin. If the amount of potassium carbonate added is less than about 0.005 parts by mass with respect to 100 parts by mass of the fat-soluble vitamin, the stabilizing effect of the fat-soluble vitamin may not be fully exhibited, and the amount of potassium carbonate added is about When the amount is more than 30 parts by mass, the stability effect of the fat-soluble vitamin may not be further improved.
- antioxidants include, for example, vitamin C and its derivatives, water-soluble components such as sodium erythorbate, catechin, gallic acid, bayberry extract, rutin, quercetin glycoside, myristin, isoquercetin, naringenin and other flavonoids, Examples thereof include chalcones such as kaempferol and derivatives thereof.
- the fat-soluble vitamin-containing composition of the present invention may be contained so that potassium carbonate comes into contact with the fat-soluble vitamin, and the form of the fat-soluble vitamin-containing composition is not particularly limited.
- potassium carbonate is contained in the fat-soluble vitamin.
- Oil-soluble vitamin-containing composition in which oil is dispersed a fat-soluble vitamin-containing composition in the form of an oil-in-water emulsion composition in an emulsion solution containing a fat-soluble vitamin and potassium carbonate, and a fat-soluble vitamin in the form of an oil-in-water emulsion composition
- Examples include a microcapsule-like fat-soluble vitamin-containing composition. Examples of the method for producing a fat-soluble vitamin-containing composition, a fat-soluble vitamin-containing composition in the form of an oil-in
- the method for producing the fat-soluble vitamin-containing composition is not particularly limited.
- the fat-soluble vitamin-containing composition can be produced by adding potassium carbonate to a fat-soluble vitamin while stirring.
- fat and fat are optionally added to the fat-soluble vitamin to prepare a fat-soluble vitamin content, and then heated to about 100 ° C. or less, preferably about 60 to 80 ° C., Potassium carbonate can be added, stirred and dispersed uniformly, and cooled to room temperature to produce a fat-soluble vitamin-containing composition.
- the fat-soluble vitamin containing composition of an oil-in-water-type emulsion composition can manufacture by emulsifying by a well-known method.
- Specific examples of the method for producing a fat-soluble vitamin-containing composition in the form of an oil-in-water emulsified composition include water, sugar, polyhydric alcohol, thickening stabilizer, emulsifier, and potassium carbonate with stirring and stirring for about 40 to Heat to about 80 ° C., preferably about 60 to 80 ° C., and slowly add fat-soluble vitamins kept at about 100 ° C. or less, preferably about 60 to 80 ° C.
- a fat-soluble vitamin-containing composition in the form of an oil-in-water emulsion can be produced by emulsifying at about 20,000 rpm for a stirring time of about 10 to 60 minutes.
- the apparatus for producing the fat-soluble vitamin-containing composition in the form of an oil-in-water emulsion composition For example, a normal stirring / mixing tank equipped with a stirrer, a heating jacket, a baffle plate, and the like is used. be able to. As a stirrer to be equipped, a high-speed rotary dispersing / emulsifying machine such as TK homomixer (manufactured by PRIMIX Co., Ltd.) or CLEARMIX (manufactured by M Technique Co., Ltd.) is preferably used. Moreover, you may further homogenize the liquid emulsified with these apparatuses using a high-pressure-type homogenizer.
- TK homomixer manufactured by PRIMIX Co., Ltd.
- CLEARMIX manufactured by M Technique Co., Ltd.
- examples of the high-pressure homogenizer include an APV gorin homogenizer (manufactured by APV), a microfluidizer (manufactured by Microfluidics), an optimizer (manufactured by Sugino Machine), or a nanomizer (manufactured by Daiwa Steel). Can be preferably used.
- a homogenizer such as an ultrasonic emulsifier may be used.
- saccharide used in the oil-in-water emulsified composition-containing fat-soluble vitamin-containing composition examples include, for example, starch degradation products, isomerized liquid sugar, octenyl succinate-starch, and the like. The above can be combined.
- Examples of the polyhydric alcohol used for the fat-soluble vitamin-containing composition in the form of an oil-in-water emulsion composition include glycerin, D-sorbitol, reduced starch degradation products, and the like. The above can be combined.
- thickening stabilizer used in a fat-soluble vitamin-containing composition in the form of an oil-in-water emulsion composition include, for example, agar, carrageenan, farseleran, alginate, locust bean gum, guar gum, tamarind gum, psyllium gum, and gum arabic. , Tragacanth gum, karaya gum, pectin, arabinogalactan, pullulan, dextran, curdlan, cellulose, hemicellulose, xanthan gum, mannan and the like, and the above thickening stabilizers can be used alone or in combination of two or more.
- Examples of the emulsifier used in the oil-in-water emulsion composition-containing fat-soluble vitamin-containing composition include, for example, glycerin fatty acid ester, glycerin organic acid fatty acid ester, polyglycerin fatty acid ester, polyglycerin condensed ricinoleic acid ester, sucrose fatty acid ester, Examples include sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, propylene glycol fatty acid ester, lecithin, saponin, and the like, and one or more of these can be used.
- the production method of the powdery fat-soluble vitamin-containing composition is not particularly limited, and the oil-soluble vitamin-containing composition in the form of an oil-in-water emulsion composition or the fat-soluble vitamin-containing composition in the form of an oil-in-water emulsion composition It can manufacture by drying what added the powdered base material etc. by a well-known method.
- a powdered base material, a thickening stabilizer, potassium carbonate and an emulsifier are added to water and stirred at about 40 to 80 ° C., preferably about 60 Heat to about 80 ° C., slowly add fat-soluble vitamins kept at about 100 ° C. or less, preferably about 60 to 80 ° C., using a high-speed rotary dispersing / emulsifying machine at a rotational speed of about 4000 to 20000 rpm and a stirring time of about 10 Emulsify for 60 minutes to obtain an emulsion containing fat-soluble vitamins.
- a powdery fat-soluble vitamin-containing composition can be produced by drying and pulverizing the emulsion containing the fat-soluble vitamin.
- drying method examples include spray drying, drum drying, belt drying, vacuum drying, and vacuum freeze drying, and spray drying is preferable.
- spray drying is preferable.
- limiting in particular in a spray-drying apparatus Well-known apparatuses, such as a spray-type spray-drying apparatus or a rotary disk type spray-drying apparatus, can be used.
- spray drying There are no particular restrictions on the operating conditions for spray drying.
- an emulsion containing a fat-soluble vitamin and potassium carbonate is supplied to a pressure nozzle type spray drying apparatus, the hot air inlet temperature is about 150 to 270 ° C., the exhaust temperature is about By spray-drying under conditions of 70 to 130 ° C.
- a powdery fat-soluble vitamin-containing composition is obtained.
- the average particle size of the obtained powder is about 20 to 200 ⁇ m, preferably about 50 to 100 ⁇ m.
- the loss on drying of the obtained powder is about 10% by mass or less, preferably about 7% by mass or less, more preferably about 5% by mass or less.
- Powdered base materials used in powdered fat-soluble vitamin-containing compositions include cyclodextrins, dextrins, lactose, casein and its salts, starch, modified starch, glucose, fructose and other simple sugars, sucrose, lactose, maltose Starch degradation products such as disaccharides, dextrin and powdered starch syrup, malto-oligosaccharides such as maltotriose, maltotetraose, maltopentaose and maltohexaose, sorbitol, mannitol, maltitol, powdered reduced starch syrup, powdered reduced palatinose, etc.
- Sugar alcohols, and the like, more preferably cyclodextrins, and the above powdered base materials can be used alone or in combination of two or more.
- Cyclodextrins are cyclic oligosaccharides that have ⁇ , ⁇ , and ⁇ structures depending on the number of glucose, methyl cyclodextrins, ethyl cyclodextrins, and hydroxyalkylated hydroxys into which lower alkyl groups have been introduced. Examples thereof include methyl cyclodextrin, hydroxyethyl cyclodextrin, hydroxypropyl cyclodextrin, hydroxybutyl cyclodextrin and the like, preferably ⁇ -cyclodextrin and ⁇ -cyclodextrin.
- a fluidity-imparting substance can be added to the powdery fat-soluble vitamin-containing composition as long as the purpose and effect of the present invention are not impaired.
- the fluidity-imparting substance include tricalcium phosphate and fine silicon dioxide.
- the fat-soluble vitamin-containing composition of each aspect thus obtained can be used for foods and drinks, pharmaceuticals, cosmetics and the like in the same manner as conventional fat-soluble vitamins and conventional fat-soluble vitamin compositions. Since the fat-soluble vitamin of the present invention is excellent in stability, stability is maintained even when blended in foods, drinks, pharmaceuticals, cosmetics and the like.
- the blending amount of the fat-soluble vitamin-containing composition of the present invention in foods and drinks, pharmaceuticals, cosmetics and the like is not particularly limited, and can be the same as the usual blending amount.
- Examples of the foods and drinks to which the fat-soluble vitamin-containing composition is added include infant formula for adding fat-soluble vitamins, functional drinks, sports drinks, and nutritional supplement drinks.
- Examples of pharmaceuticals to which a fat-soluble vitamin-containing composition is added include eye drops, infusions, and the like, and cosmetics to which a fat-soluble vitamin-containing composition is added include, for example, skin beautifying agents, hairdressing agents, hair restorers, and the like. Can be mentioned.
- Fat-soluble vitamin-containing composition (1) Raw materials (a) Fat-soluble vitamins Vitamin E (Product name: Riken E Oil 705; manufactured by Riken Vitamin Co., Ltd., total tocopherol content 68% by mass or more, d- ⁇ -tocopherol content 35%) Vitamin A (Product name: Vitamin A fatty acid ester; manufactured by BASF Japan, Vitamin A palmitate content 1.7 million IU / g) Vitamin D (Product name: Riken D3 Oil 100; manufactured by Riken Vitamin Co., Ltd., vitamin D3 content 100,000 IU / g) (B) Potassium carbonate carbonate (Product name: Potassium carbonate; Wako Pure Chemical Industries, Ltd.) Sodium carbonate (Product name: Sodium carbonate; manufactured by Junsei Kagaku) Calcium carbonate (Product name: Calcium carbonate; Wako Pure Chemical Industries, Ltd.)
- Table 1 shows the composition of the fat-soluble vitamin-containing composition prepared using the above raw materials.
- Method for Measuring Vitamin E The test solution and standard solution were prepared by the quantitative method described in the method for measuring d- ⁇ -tocopherol (D-1183 to 1184) in the Food Additives Official Document (8th Edition). About this test solution and a standard solution, it measured on the following conditions using the high performance liquid chromatography, and calculated
- Detector UV absorption photometer (Product name: SPD-10AV; manufactured by Shimadzu Corporation) Detection wavelength: 292 nm
- Mobile phase: hexane: 2-propanol mixed solution 98: 2 Flow rate: 1.0 mL / min
- Vitamin A measurement method Vitamin A content was determined by the quantitative method described in (D-1339) described in the measurement method of vitamin A fatty acid ester in the Food Additives Official Manual (8th edition). At that time, the absorbance was measured using an ultraviolet spectrophotometer (model: U-3310; manufactured by Hitachi, Ltd.).
- Vitamin D As the vitamin D of the fat-soluble vitamin-containing composition (vitamin D-containing product) of the present invention, about 2500 I.D. U. Precisely measure the amount corresponding to, put in a brown test tube with a stopper, add about 5 mg of butylhydroxytoluene and 5 mL of n-hexane, and completely remove n-hexane in a water bath at 40-60 ° C. It was. Precisely weigh about 30 mg of a standard solution of vitamin D3 (Japanese Pharmacopoeia) into a 100 mL brown volumetric flask, add about 5 mg of butylhydroxytoluene and make up with n-hexane.
- vitamin D3 Japanese Pharmacopoeia
- Detector UV spectrophotometer (Product name: SPD-10AV; manufactured by Shimadzu Corporation) Detection wavelength: 265 nm
- Mobile phase: hexane: 2-propanol mixed solution 95: 5 Flow rate: 0.5mL / min
- the numerical values in the table are each mass% (residual rate) of the fat-soluble vitamins after storage, with the fat-soluble vitamins immediately after creation as 100 mass%.
- the fat-soluble vitamin-containing composition containing potassium carbonate as an example had a high residual ratio of fat-soluble vitamins, and was a good result even after long-term storage.
- the comparative product containing no potassium carbonate had a low residual ratio of fat-soluble vitamins and had poor stability.
- [Powdered fat-soluble vitamin-containing composition] (1) Raw material Vitamin A (Product name: Vitamin A fatty acid ester, manufactured by BASF Japan Ltd. Vitamin A palmitate content 1.7 million IU / g) ⁇ -cyclodextrin (trade name: CAVAMAX® W7 Food; manufactured by Cyclochem) Dextrin (trade name: Paindex # 2; manufactured by Matsutani Chemical Industry Co., Ltd.) Gum arabic (trade name: Arabic Coal SS; manufactured by Sanei Pharmaceutical Trading Co., Ltd.) Potassium carbonate (Product name: Potassium carbonate; Wako Pure Chemical Industries, Ltd.)
- Table 3 shows the formulation of powdered fat-soluble vitamin-containing composition prepared using the above raw materials.
- the production amount of each emulsified solution at a time is 1500 g.
- the obtained emulsified solution was spray-dried (air blowing temperature 180 ° C.) using a spray dryer (model: L-8i; manufactured by Okawara Kako Co., Ltd.) and powdered fat-soluble vitamin-containing composition (Example Product 7, 8 Comparative example products 6 and 7) were obtained.
- the numerical values in the table are each mass% (residual rate) of the fat-soluble vitamins after storage, with the fat-soluble vitamins immediately after creation as 100 mass%.
- the powdered fat-soluble vitamin-containing composition containing potassium carbonate which is an example, has a high residual ratio of fat-soluble vitamins and good stability even during long-term storage. Met.
- the comparative product which does not contain potassium carbonate had a low residual rate of fat-soluble vitamins and had poor stability.
- Example product 7 (powdered fat-soluble vitamin-containing composition containing vitamin A and potassium carbonate)
- Table 5 shows the formulation of food containing the powdered fat-soluble vitamin-containing composition prepared using the above raw materials.
- the numerical values in the table are each mass% (residual rate) of the fat-soluble vitamins after storage with the fat-soluble vitamins immediately after creation (before heat sterilization) as 100 mass%.
- the powdered fat-soluble vitamin-containing composition containing potassium carbonate has a high residual ratio of fat-soluble vitamins even in jelly beverages and good stability during storage. Met.
- the fat-soluble vitamin-containing composition containing no potassium carbonate has a poor stability when stored in a jelly beverage.
- a fat-soluble vitamin-containing composition with improved stability is provided.
- the fat-soluble vitamin-containing composition provided by the present invention is stable, suppresses a decrease in the content of the fat-soluble vitamin, has little change in quality over time, and is fat-soluble even when the fat-soluble vitamin-containing composition is added to food and drink. Industrial applicability is tremendous in that the decrease in vitamin content is suppressed.
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Abstract
Description
すなわち、本発明は、
1.脂溶性ビタミンと炭酸カリウムとを含有することを特徴とする脂溶性ビタミン含有組成物、
2.上記1に記載の脂溶性ビタミン含有組成物を含むことを特徴とする飲食品、
3.炭酸カリウムを脂溶性ビタミンに添加することを特徴とする、脂溶性ビタミン含有組成物の安定化方法、
からなっている。
また、脂溶性ビタミンが天然物より抽出精製して得たものである場合、抽出原料由来の食用油脂を含むものであっても良い。
以下に脂溶性ビタミン含有組成物、水中油型乳化組成物状の脂溶性ビタミン含有組成物及び粉末状の脂溶性ビタミン含有組成物の製造方法について例示する。
脂溶性ビタミン含有組成物の製造方法の具体例としては、脂溶性ビタミンに所望により油脂を加えて脂溶性ビタミン含量を調製した後、約100℃以下、好ましくは約60~80℃に加熱し、炭酸カリウムを加えて攪拌し均一に分散させ、室温まで冷却して脂溶性ビタミン含有組成物を製造することができる。
水中油型乳化組成物状の脂溶性ビタミン含有組成物の製造方法の具体例としては、水、糖類、多価アルコール、増粘安定剤、乳化剤、および炭酸カリウムを加えて攪拌しながら約40~80℃、好ましくは約60~80℃に加熱し、約100℃以下、好ましくは約60~80℃に保持した脂溶性ビタミンをゆっくり加えながら高速回転式分散・乳化機を用いて回転数約4000~20000rpmで攪拌時間約10~60分間乳化することにより、水中油型乳化組成物状の脂溶性ビタミン含有組成物を製造することができる。
本発明の脂溶性ビタミンは安定性に優れているため、飲食品、医薬品、化粧品などに配合した場合においても安定性は保持される。
本発明の脂溶性ビタミン含有組成物の飲食品、医薬品、化粧品などへの配合量は特に制限されず、通常の配合量と同量とすることができる。
脂溶性ビタミン含有組成物を添加する医薬品としては、例えば、点眼薬、点滴などが挙げられ、脂溶性ビタミン含有組成物を添加する化粧品としては、例えば、美肌剤、美毛剤、育毛剤などが挙げられる。
(1)原材料
(a)脂溶性ビタミン
ビタミンE(製品名:理研Eオイル705;理研ビタミン社製、総トコフェロール含量68質量%以上、d-α-トコフェロール含量35%)
ビタミンA(製品名:ビタミンA脂肪酸エステル;BASFジャパン社製、ビタミンAパルミテート含量170万I.U./g)
ビタミンD(製品名:理研D3オイル100;理研ビタミン社製、ビタミンD3含量10万I.U./g)
(b)炭酸塩
炭酸カリウム(製品名:炭酸カリウム;和光純薬工業社製)
炭酸ナトリウム(製品名:炭酸ナトリウム;純正化学社製)
炭酸カルシウム(製品名:炭酸カルシウム;和光純薬工業社製)
上記原材料を用いて作製した脂溶性ビタミン含有組成物の配合を表1に示した。
表1に示した配合に基づいて各原材料を混合し脂溶性ビタミン含有組成物(実施例品1~6、比較例品1~5)を作製した。尚、混合は500mLビーカーに各原材料を入れ、約60℃に加熱し、攪拌機(製品名:スリーワンモーター、形式:FBL-600;HEIDON社製)を用いて、約300rpmで15分間攪拌して行った。
得られた脂溶性ビタミン含有組成物(実施例品1~6、比較例品1~5)各10gをガラスシャーレにとり、55℃の暗所で保管した。ビタミンEを用いた含有組成物の保管期間は30日間、70日間とし、ビタミンA、ビタミンDを使用した脂溶性ビタミン含有組成物の保管期間は4日間、8日間、12日間とした。
脂溶性ビタミン含有組成物中に含まれる脂溶性ビタミン含量を測定し、作製直後の脂溶性ビタミンを100質量%として保管後の脂溶性ビタミンの含有質量%(残存率)を計算した。結果を表2に示す。
ビタミンEの測定方法
食品添加物公定書解説書(第8版)のd-α-トコフェロールの測定方法に記載(D-1183~1184)の定量方法で検液及び標準液を調整した。この検液及び標準液について高速液体クロマトグラフィを用いて下記条件で測定し、総トコフェロール(ビタミンE)の含量を求めた。
検出器:紫外線吸光光度計(製品名:SPD-10AV;島津製作所社製)
検出波長:292nm
カラム:Finepak SIL C18T-5 φ4.6×25cm(日本分光社製)
移動相:ヘキサン:2-プロパノール混液=98:2
流量:1.0mL/min
カラム温度:40℃
注入量:20μL
食品添加物公定書解説書(第8版)のビタミンA脂肪酸エステルの測定方法に記載(D-1339)の定量方法で測定してビタミンAの含量を求めた。その際吸光度測定は、紫外分光光度計(型式:U-3310;日立製作所社製)を用いて行った。
本発明の脂溶性ビタミン含有組成物(ビタミンD含有品)のビタミンDとして約2500I.U.に対応する量を精密に量り、共栓付き褐色試験管に入れ、ブチルヒドロキシトルエン約5mg、n-ヘキサン5mLを加え、40~60℃の水浴中でn-ヘキサンを完全に除去して検液とした。
ビタミンD3の標準原液(日本薬局方適合品)約30mgを100mL褐色メスフラスコに精密に量り入れ、ブチルヒドロキシトルエン約5mgを加えてn-ヘキサンでメスアップする。ここから正確に5mLを量り50mL容褐色メスフラスコに入れてn-ヘキサンでメスアップした。さらにここから正確に10mLを量り、50mL容褐色メスフラスコに入れてn-ヘキサンでメスアップして標準液とした。
得られた検液及び標準液を、高速液体クロマトグラフィを用いて下記条件で測定し、標準品の分析結果(ピーク面積)をもとにビタミンDの含量を求めた。
検出器:紫外吸光光度計(製品名:SPD-10AV;島津製作所社製)
検出波長:265nm
カラム:Resolve silica 5μm:φ3.9×150mm(Waters社製)
移動相:ヘキサン:2-プロパノール混液=95:5
流量:0.5mL/min
カラム温度:30℃
注入量:50μL
(1)原材料
ビタミンA(製品名:ビタミンA脂肪酸エステル、BASFジャパン社製 ビタミンAパルミテート含量170万I.U./g)
β-サイクロデキストリン(商品名:CAVAMAX(R) W7 Food;シクロケム社製)
デキストリン(商品名:パインデックス#2;松谷化学工業社製)
アラビアガム(商品名:アラビックコールSS;三栄薬品貿易社製)
炭酸カリウム(製品名:炭酸カリウム;和光純薬工業社製)
上記原材料を用いて作製した粉末状の脂溶性ビタミン含有組成物の配合を、表3に示した。
表3に示した配合に基づいて各原材料を下記方法で乳化液とした後乾燥し、粉末状の脂溶性ビタミン含有組成物(実施例品7、8、比較例品6、7)を作製した。
表3に示したビタミンA以外の原材料を2L容ステンレス製ジョッキに加えてゆっくり混合しながら、液温60℃まで加温し、60℃を保ちながら10分間混合した後、ビタミンAを加えてT.K.ホモキキサー(型式:MARK II型;プライミクス社製)を用いて8000rpmで15分間撹拌し乳化溶液を得た。各乳化溶液の1回の作製量は1500gである。
得られた乳化溶液をスプレードライヤ(型式:L-8i;大川原化工機社製)を使用して、噴霧乾燥(送風温度180℃)し粉末状の脂溶性ビタミン含有組成物(実施例品7、8 比較例品6、7)を得た。
得られた粉末状の脂溶性ビタミン含有組成物(実施例品7、8 比較例品6、7)の各300gを1L容のポリ袋に入れ、40℃暗所で30日間、60日間、90日間保管した。粉末状の脂溶性ビタミン含有組成物中に含まれる脂溶性ビタミン(ビタミンA)含量を測定し、作製直後の脂溶性ビタミン含量を100質量%として保管後の脂溶性ビタミンの含有質量%(残存率)を計算した。結果を表4に示す。
(1)ゼリー飲料の作製
3L容ステンレス製ジョッキにイオン交換水1500gをとり、これにクエン酸(和光純薬工業社製)2.55gとクエン酸ナトリウム(和光純薬工業社製)1.80gを加え、攪拌機(製品名:スリーワンモーター、形式:FBL-600;HEIDON社製)にて混合して溶解した。そこに粉寒天(商品名:伊那寒天S-7;伊那食品工業社製)12.0g、カラギーナン(商品名:GENUGELカラギナン WG-108;CP Kelco社製)7.5gを加え、攪拌機(製品名:スリーワンモーター 形式:FBL-600;HEIDON社製)150rpmで、60℃・5分間混合してゼリー飲料を得た。得られたゼリー飲料(品温25℃)をpHメータ(型式:HM-30R;東亜ディ-ケーケー社製)で測定したところpH3.8であった。
ゼリー飲料((1)ゼリー飲料の作製で得たゼリー飲料 pH3.8)
実施例品7(ビタミンAと炭酸カリウムを含有する粉末状の脂溶性ビタミン含有組成物)
実施例品8(ビタミンAと炭酸カリウムを含有する粉末状の脂溶性ビタミン含有組成物)
比較例品6(ビタミンAを含有する粉末状の脂溶性ビタミン含有組成物)
比較例品7(ビタミンAを含有する粉末状の脂溶性ビタミン含有組成物)
上記原材料を用いて作製した粉末の脂溶性ビタミン含有組成物を含有する食品の配合を表5に示した。
表5のゼリー飲料300gを500mL容ビーカーにとり、攪拌機(製品名:スリーワンモーター 形式:FBL-600;HEIDON社製)にて攪拌しながら加温して85℃に保温して、攪拌しながら粉末状の脂溶性ビタミン含有組成物(実施例品7、8 比較例品6、7)各0.09gを加えて撹拌し、粉末状の脂溶性ビタミン含有組成物を含むゼリー飲料(実施例品9、10 比較例品8、9)を得た。
得られた粉末状の脂溶性ビタミン含有組成物を含むゼリー飲料100gを、レトルトパウチに加えて密封した後、高圧蒸気滅菌装置(オートクレーブ 型式:SN200;ヤマト科学社製)にて105℃、2分間の加熱殺菌処理を行った。次いで殺菌済みの粉末状の脂溶性ビタミン含有組成物を含むゼリー飲料を、40℃暗所で14日間、28日間保管した。
粉末状の脂溶性ビタミン含有組成物を含有するゼリー飲料中に含まれる脂溶性ビタミン(ビタミンA)含量を測定し、作製直後(加熱殺菌前)の脂溶性ビタミン含量を100質量%として殺菌後、保管後の脂溶性ビタミンの含有質量%(残存率)を計算した。結果を表6に示す。
Claims (5)
- 脂溶性ビタミンと炭酸カリウムとを含有することを特徴とする脂溶性ビタミン含有組成物。
- 脂溶性ビタミン100質量部に対して炭酸カリウムを0.005~30質量部含有する請求項1に記載の脂溶性ビタミン含有組成物。
- 請求項1又は2に記載の脂溶性ビタミン含有組成物を含むことを特徴とする飲食品。
- 炭酸カリウムを脂溶性ビタミンに添加することを特徴とする、脂溶性ビタミン含有組成物の安定化方法。
- 脂溶性ビタミン100質量部に対して炭酸カリウムを0.005~30質量部添加することからなる請求項4に記載の脂溶性ビタミン含有組成物の安定化方法。
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CN113952358A (zh) * | 2021-11-24 | 2022-01-21 | 合肥远志医药科技开发有限公司 | 一种碳酸钙维生素d3组合物及其制备方法 |
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JPWO2011040141A1 (ja) | 2013-02-21 |
TWI531321B (zh) | 2016-05-01 |
JP5836127B2 (ja) | 2015-12-24 |
CN102639011A (zh) | 2012-08-15 |
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