WO2009134076A3 - 방출성이 제어된 안지오텐신 - II - 수용체 차단제와 H M G - C o A 환원 효소 억제제의 복합제 조성물 - Google Patents
방출성이 제어된 안지오텐신 - II - 수용체 차단제와 H M G - C o A 환원 효소 억제제의 복합제 조성물 Download PDFInfo
- Publication number
- WO2009134076A3 WO2009134076A3 PCT/KR2009/002256 KR2009002256W WO2009134076A3 WO 2009134076 A3 WO2009134076 A3 WO 2009134076A3 KR 2009002256 W KR2009002256 W KR 2009002256W WO 2009134076 A3 WO2009134076 A3 WO 2009134076A3
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- Prior art keywords
- hmg
- angiotensin
- controlled
- coa reductase
- combination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
본 발명은 방출성이 제어된 안지오텐신-II-수용체 차단제와 HMG-CoA 환원효소 억제제의 복합제 조성물에 관한 것으로서, 복합 성분 각각의 체내 약리 작용 발현 시간에 차이를 두어 투약하는 원리를 적용하여 각 성분을 특정 속도로 제어 방출할 수 있도록 설계한 복합제 조성물에 관한 발명으로서 당뇨병, 비만증, 고지혈증, 관상 동맥 질환 등이 복합적으로 나타나는 이른바 대사성 증후군을 지닌 자들의 고혈압 치료와 합병증 예방에 매우 효과적인 약학 조성물 및 그의 제제화 방법에 관한 것이다. 보다 상세하게는 특정 속도로 약물을 제어 방출 하도록 설계된 약물 송달 시스템으로서 체내 흡수 시 가장 이상적인 효과를 나타낼 수 있도록 하였으며, 환자의 복약 순응도를 높여 외적인 요소에서도 효과를 극대화시킬 수 있는 방출성이 제어된 안지오텐신-II-수용체 차단제와 HMG-CoA 환원효소 억제제의 시간차 투여 복합제 조성물에 관한 것이다.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2008-0039864 | 2008-04-29 | ||
| KR20080039864 | 2008-04-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2009134076A2 WO2009134076A2 (ko) | 2009-11-05 |
| WO2009134076A3 true WO2009134076A3 (ko) | 2010-02-18 |
Family
ID=41255555
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2009/002278 WO2009134086A2 (ko) | 2008-04-29 | 2009-04-29 | 심혈관계 질환 치료용 약제학적 제제 |
| PCT/KR2009/002256 WO2009134076A2 (ko) | 2008-04-29 | 2009-04-29 | 방출성이 제어된 안지오텐신 - II - 수용체 차단제와 H M G - C o A 환원 효소 억제제의 복합제 조성물 |
| PCT/KR2009/002261 WO2009134079A2 (ko) | 2008-04-29 | 2009-04-29 | 약제학적 제제 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2009/002278 WO2009134086A2 (ko) | 2008-04-29 | 2009-04-29 | 심혈관계 질환 치료용 약제학적 제제 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2009/002261 WO2009134079A2 (ko) | 2008-04-29 | 2009-04-29 | 약제학적 제제 |
Country Status (2)
| Country | Link |
|---|---|
| KR (15) | KR101238156B1 (ko) |
| WO (3) | WO2009134086A2 (ko) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101248804B1 (ko) * | 2010-05-14 | 2013-03-29 | 한미사이언스 주식회사 | ＨＭＧ-ＣｏＡ 환원효소 억제제 및 이베살탄을 포함하는 이층정 약제학적 복합제제 |
| SI2787993T1 (sl) * | 2011-12-09 | 2017-04-26 | Ims Medical D.O.O. | Tretiranje arterijskih sten s kombinacijo raas zaviralcev in zaviralcev hmg-coa reduktaze |
| KR20130076015A (ko) | 2011-12-28 | 2013-07-08 | 주식회사 삼양바이오팜 | 높은 경도를 갖는 속붕정 및 이의 제조 방법 |
| KR20140030505A (ko) * | 2012-08-31 | 2014-03-12 | 한미약품 주식회사 | 이베살탄 및 ＨＭＧ-ＣｏＡ 환원효소 억제제를 포함하는 약제학적 캡슐 복합제제 |
| KR20140028971A (ko) * | 2012-08-31 | 2014-03-10 | 한미약품 주식회사 | 아토바스타틴, 이르베살탄 및 탄산마그네슘을 포함하는 이층정 복합제제 |
| KR20160105662A (ko) * | 2015-02-27 | 2016-09-07 | 대원제약주식회사 | 에페리손과 펠루비프로펜을 함유하는 약제학적 조성물 |
| KR102145853B1 (ko) * | 2018-06-19 | 2020-08-19 | 한국유나이티드제약 주식회사 | 실로스타졸과 스타틴계약물을 함유하는 약학 조성물 |
| KR102042626B1 (ko) | 2019-06-26 | 2019-11-11 | 한미약품 주식회사 | 이베살탄 및 ＨＭＧ-ＣｏＡ 환원효소 억제제를 포함하는 약제학적 캡슐 복합제제 |
| KR102104507B1 (ko) * | 2019-08-23 | 2020-04-24 | 브릿지바이오테라퓨틱스(주) | 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법 |
| KR102304910B1 (ko) * | 2021-01-11 | 2021-09-27 | 알리코제약(주) | 칸데사르탄을 함유하는 안정한 약학적 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20010022508A (ko) * | 1997-07-31 | 2001-03-15 | 추후보정 | 3-히드록시-3-메틸글루타릴 조효소 ａ 환원 효소 억제제와니코틴산 화합물의 조성물 및 야간에 1일 1회 투여하여고지질혈증을 치료하는 방법 |
| KR20040079980A (ko) * | 2002-02-01 | 2004-09-16 | 데포메드 인코퍼레이티드 | 속방성 및 서방성 약물 모두를 송달하는 경구 투약 형태의제조방법 |
| KR20060064048A (ko) * | 2003-07-18 | 2006-06-12 | 데포메드 인코퍼레이티드 | 약물 분리가 개선된 이중 약물 제형 |
| KR20070078625A (ko) * | 2006-01-27 | 2007-08-01 | 씨제이 주식회사 | 멀티플 유닛 타입 서방성 경구 제제 및 그 제조방법 |
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| KR100582347B1 (ko) * | 2004-12-30 | 2006-05-22 | 한미약품 주식회사 | 3-하이드록시-3-메틸글루타릴 조효소 ａ 환원효소 억제제및 고혈압 치료제의 복합제제 및 그의 제조방법 |
| KR100648825B1 (ko) * | 2005-02-22 | 2006-11-24 | 한국유나이티드제약 주식회사 | 당뇨병 환자의 동맥경화증 예방을 위한 혈당강하제, 에이치엠지이-씨오에이 환원효소 저해제 및 장용코팅된 아스피린을 함유하는 복합 펠렛 |
| WO2008023869A1 (en) * | 2006-08-24 | 2008-02-28 | Hanall Pharmaceutical Co., Ltd. | Combined pharmeceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors |
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2009
- 2009-04-29 KR KR1020090037380A patent/KR101238156B1/ko not_active IP Right Cessation
- 2009-04-29 KR KR1020090037371A patent/KR101205633B1/ko not_active IP Right Cessation
- 2009-04-29 KR KR1020090037373A patent/KR20090114321A/ko not_active Application Discontinuation
- 2009-04-29 WO PCT/KR2009/002278 patent/WO2009134086A2/ko active Application Filing
- 2009-04-29 KR KR1020090037372A patent/KR20090114320A/ko not_active Application Discontinuation
- 2009-04-29 KR KR1020090037422A patent/KR20090114333A/ko not_active Application Discontinuation
- 2009-04-29 KR KR1020090037375A patent/KR20090114323A/ko not_active Application Discontinuation
- 2009-04-29 WO PCT/KR2009/002256 patent/WO2009134076A2/ko active Application Filing
- 2009-04-29 KR KR1020090037374A patent/KR20090114322A/ko not_active Application Discontinuation
- 2009-04-29 KR KR1020090037381A patent/KR20090114329A/ko not_active Application Discontinuation
- 2009-04-29 KR KR1020090037376A patent/KR20090114324A/ko not_active Application Discontinuation
- 2009-04-29 KR KR1020090037379A patent/KR101230731B1/ko active IP Right Grant
- 2009-04-29 KR KR1020090037377A patent/KR20090114325A/ko not_active Application Discontinuation
- 2009-04-29 KR KR1020090037420A patent/KR20090114331A/ko not_active Application Discontinuation
- 2009-04-29 KR KR1020090037421A patent/KR20090114332A/ko not_active Application Discontinuation
- 2009-04-29 WO PCT/KR2009/002261 patent/WO2009134079A2/ko active Application Filing
- 2009-04-29 KR KR1020090037382A patent/KR20090114330A/ko not_active Application Discontinuation
- 2009-04-29 KR KR1020090037378A patent/KR20090114326A/ko not_active Application Discontinuation
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| KR20010022508A (ko) * | 1997-07-31 | 2001-03-15 | 추후보정 | 3-히드록시-3-메틸글루타릴 조효소 ａ 환원 효소 억제제와니코틴산 화합물의 조성물 및 야간에 1일 1회 투여하여고지질혈증을 치료하는 방법 |
| KR20040079980A (ko) * | 2002-02-01 | 2004-09-16 | 데포메드 인코퍼레이티드 | 속방성 및 서방성 약물 모두를 송달하는 경구 투약 형태의제조방법 |
| KR20060064048A (ko) * | 2003-07-18 | 2006-06-12 | 데포메드 인코퍼레이티드 | 약물 분리가 개선된 이중 약물 제형 |
| KR20070078625A (ko) * | 2006-01-27 | 2007-08-01 | 씨제이 주식회사 | 멀티플 유닛 타입 서방성 경구 제제 및 그 제조방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090114319A (ko) | 2009-11-03 |
| KR101238156B1 (ko) | 2013-02-27 |
| KR20090114328A (ko) | 2009-11-03 |
| KR20090114332A (ko) | 2009-11-03 |
| WO2009134086A3 (ko) | 2010-01-21 |
| WO2009134079A3 (ko) | 2010-01-21 |
| WO2009134086A2 (ko) | 2009-11-05 |
| WO2009134086A9 (ko) | 2010-03-11 |
| KR20090114331A (ko) | 2009-11-03 |
| WO2009134079A9 (ko) | 2010-03-11 |
| KR20090114322A (ko) | 2009-11-03 |
| KR101230731B1 (ko) | 2013-02-07 |
| KR20090114320A (ko) | 2009-11-03 |
| KR20090114329A (ko) | 2009-11-03 |
| KR20090114324A (ko) | 2009-11-03 |
| KR20090114325A (ko) | 2009-11-03 |
| KR20090114333A (ko) | 2009-11-03 |
| KR101205633B1 (ko) | 2012-11-27 |
| KR20090114321A (ko) | 2009-11-03 |
| KR20090114327A (ko) | 2009-11-03 |
| WO2009134079A2 (ko) | 2009-11-05 |
| KR20090114330A (ko) | 2009-11-03 |
| KR20090114323A (ko) | 2009-11-03 |
| KR20090114326A (ko) | 2009-11-03 |
| WO2009134076A2 (ko) | 2009-11-05 |
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