WO2008139703A1 - 肺疾患治療薬 - Google Patents

肺疾患治療薬 Download PDF

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Publication number
WO2008139703A1
WO2008139703A1 PCT/JP2008/001081 JP2008001081W WO2008139703A1 WO 2008139703 A1 WO2008139703 A1 WO 2008139703A1 JP 2008001081 W JP2008001081 W JP 2008001081W WO 2008139703 A1 WO2008139703 A1 WO 2008139703A1
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
agent
pulmonary disease
pulmonary diseases
disclosed
Prior art date
Application number
PCT/JP2008/001081
Other languages
English (en)
French (fr)
Inventor
Kensuke Egashira
Junji Kojima
Megumi Sakamoto
Original Assignee
Kyushu University, National University Corporation
Kowa Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyushu University, National University Corporation, Kowa Co., Ltd. filed Critical Kyushu University, National University Corporation
Priority to CA2685054A priority Critical patent/CA2685054C/en
Priority to CN2008800137806A priority patent/CN101668542B/zh
Priority to US12/596,996 priority patent/US20100086615A1/en
Priority to JP2009513998A priority patent/JP4896220B2/ja
Priority to EP08751606.8A priority patent/EP2140882B1/en
Priority to ES08751606T priority patent/ES2425969T3/es
Priority to KR1020097021959A priority patent/KR101530393B1/ko
Publication of WO2008139703A1 publication Critical patent/WO2008139703A1/ja
Priority to HK10108116.0A priority patent/HK1141708A1/xx

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

　有効性が高く、かつ副作用の少ない肺疾患治療薬の提供。 　ＨＭＧ－ＣｏＡリダクターゼ阻害剤を含む生体適合性ポリマーナノ粒子を含有する気管内投与用肺疾患治療薬。
PCT/JP2008/001081 2007-04-27 2008-04-25 肺疾患治療薬 WO2008139703A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2685054A CA2685054C (en) 2007-04-27 2008-04-25 Agent for treatment of pulmonary disease
CN2008800137806A CN101668542B (zh) 2007-04-27 2008-04-25 肺病治疗药
US12/596,996 US20100086615A1 (en) 2007-04-27 2008-04-25 Agent for treatment of pulmonary disease
JP2009513998A JP4896220B2 (ja) 2007-04-27 2008-04-25 肺疾患治療薬
EP08751606.8A EP2140882B1 (en) 2007-04-27 2008-04-25 Agent for treatment of pulmonary disease
ES08751606T ES2425969T3 (es) 2007-04-27 2008-04-25 Agente para el tratamiento de enfermedades pulmonares
KR1020097021959A KR101530393B1 (ko) 2007-04-27 2008-04-25 폐질환 치료약
HK10108116.0A HK1141708A1 (en) 2007-04-27 2010-08-25 Agent for treatment of pulmonary disease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-119553 2007-04-27
JP2007119553 2007-04-27
JP2007155816 2007-06-13
JP2007-155816 2007-06-13

Publications (1)

Publication Number Publication Date
WO2008139703A1 true WO2008139703A1 (ja) 2008-11-20

Family

ID=40001929

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/001081 WO2008139703A1 (ja) 2007-04-27 2008-04-25 肺疾患治療薬

Country Status (10)

Country Link
US (1) US20100086615A1 (ja)
EP (1) EP2140882B1 (ja)
JP (1) JP4896220B2 (ja)
KR (1) KR101530393B1 (ja)
CN (1) CN101668542B (ja)
CA (1) CA2685054C (ja)
ES (1) ES2425969T3 (ja)
HK (1) HK1141708A1 (ja)
PT (1) PT2140882E (ja)
WO (1) WO2008139703A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014516044A (ja) * 2011-05-25 2014-07-07 ユストゥス−リービッヒ−ウニヴェルジテート・ギーセン 肺に投与するための活性成分を含有する生体適合性ナノポリマー粒子
JP2015164420A (ja) * 2014-02-10 2015-09-17 公立大学法人首都大学東京 クロマチン構造制御剤
WO2021167088A1 (ja) * 2020-02-21 2021-08-26 良和 中岡 肺高血圧症改善用組成物、肺高血圧症の予後予測方法、肺高血圧症の重症度判定補助方法および肺高血圧症の診断補助方法

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EP2526927A1 (de) * 2011-05-25 2012-11-28 Justus-Liebig-Universität Gießen Biokompatible Nano- und Mikropartikel beschichtet mit Stabilisatoren für die pulmonale Applikation
WO2016076227A1 (ja) * 2014-11-10 2016-05-19 正明 伊井 幹細胞機能増強用スタチン封入ナノ粒子製剤、並びにそれを含有する機能増強幹細胞及びその製造方法
KR20200141501A (ko) * 2016-05-06 2020-12-18 각코우호징 오사카 이카야쿠카 다이가쿠 염증성 질환 치료용 줄기세포의 기능 강화를 위한 스타틴 봉입 나노입자 제제, 및 이를 함유하는 염증성 질환 치료용 기능 강화 줄기세포
KR20200130704A (ko) * 2018-02-26 2020-11-19 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. 약물 전달 시스템
JP2019196342A (ja) * 2018-05-10 2019-11-14 学校法人大阪医科薬科大学 スタチン封入ナノ粒子製剤、それを含有する歯髄由来幹細胞及びそれを含む細胞製剤。
US20230014352A1 (en) * 2019-03-29 2023-01-19 The Regents Of The University Of California Inhaled statins as bronchodilators to improve lung function in respiratory diseases

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JP2014516044A (ja) * 2011-05-25 2014-07-07 ユストゥス−リービッヒ−ウニヴェルジテート・ギーセン 肺に投与するための活性成分を含有する生体適合性ナノポリマー粒子
JP2015164420A (ja) * 2014-02-10 2015-09-17 公立大学法人首都大学東京 クロマチン構造制御剤
WO2021167088A1 (ja) * 2020-02-21 2021-08-26 良和 中岡 肺高血圧症改善用組成物、肺高血圧症の予後予測方法、肺高血圧症の重症度判定補助方法および肺高血圧症の診断補助方法

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JP4896220B2 (ja) 2012-03-14
CA2685054C (en) 2014-11-04
KR20100015758A (ko) 2010-02-12
HK1141708A1 (en) 2010-11-19
CA2685054A1 (en) 2008-11-20
KR101530393B1 (ko) 2015-06-19
EP2140882A4 (en) 2010-05-26
ES2425969T3 (es) 2013-10-18
JPWO2008139703A1 (ja) 2010-07-29
CN101668542B (zh) 2012-06-27
EP2140882B1 (en) 2013-08-14
PT2140882E (pt) 2013-09-30
CN101668542A (zh) 2010-03-10
EP2140882A1 (en) 2010-01-06

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