WO2009048072A1 - 破骨細胞関連蛋白質Ｓｉｇｌｅｃ－１５を標的とした抗体 - Google Patents

破骨細胞関連蛋白質Ｓｉｇｌｅｃ－１５を標的とした抗体 Download PDF

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Publication number
WO2009048072A1
WO2009048072A1 PCT/JP2008/068287 JP2008068287W WO2009048072A1 WO 2009048072 A1 WO2009048072 A1 WO 2009048072A1 JP 2008068287 W JP2008068287 W JP 2008068287W WO 2009048072 A1 WO2009048072 A1 WO 2009048072A1
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WIPO (PCT)
Prior art keywords
abnormality
related protein
bone metabolism
antibody targeting
protein siglec
Prior art date
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PCT/JP2008/068287
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English (en)
French (fr)
Inventor
Yoshiharu Hiruma
Eisuke Tsuda
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40549216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009048072(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to MX2010003884A priority Critical patent/MX2010003884A/es
Priority to CN200880110441.XA priority patent/CN101896501B/zh
Priority to PL08838427T priority patent/PL2206727T3/pl
Priority to JP2009537006A priority patent/JPWO2009048072A1/ja
Priority to BRPI0818437A priority patent/BRPI0818437B8/pt
Priority to KR1020107005095A priority patent/KR101534884B1/ko
Priority to NZ583397A priority patent/NZ583397A/en
Priority to CA2698326A priority patent/CA2698326C/en
Priority to ES08838427.6T priority patent/ES2540733T3/es
Priority to AU2008311698A priority patent/AU2008311698C1/en
Priority to SI200831433T priority patent/SI2206727T1/sl
Priority to DK08838427.6T priority patent/DK2206727T3/en
Priority to KR1020157004726A priority patent/KR101577935B1/ko
Priority to RU2010106639/10A priority patent/RU2475499C2/ru
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Priority to EP08838427.6A priority patent/EP2206727B1/en
Priority to US12/677,621 priority patent/US8546540B2/en
Publication of WO2009048072A1 publication Critical patent/WO2009048072A1/ja
Priority to IL204607A priority patent/IL204607A/en
Priority to HK11100127.3A priority patent/HK1145847A1/xx
Priority to AU2012201263A priority patent/AU2012201263B9/en
Priority to US13/457,967 priority patent/US9090692B2/en
Priority to US13/481,016 priority patent/US10723800B2/en
Priority to IL234078A priority patent/IL234078B/en
Priority to HRP20150485TT priority patent/HRP20150485T1/hr
Priority to US14/826,515 priority patent/US9815899B2/en
Priority to US15/729,947 priority patent/US10308715B2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

破骨細胞で強く発現する遺伝子を用いた骨代謝異常の検出方法、骨代謝異常治療及び／又は予防効果を有する化合物のスクリーニング法、及び骨代謝異常治療及び／又は予防用医薬組成物を提供すること。ヒトＳｉｇｌｅｃ－１５遺伝子の発現を指標とした骨代謝異常の検出方法、及びヒトＳｉｇｌｅｃ－１５を特異的に認識し、破骨細胞の形成を抑制する活性を有する抗体を含む医薬組成物の提供等。
PCT/JP2008/068287 2007-10-11 2008-10-08 破骨細胞関連蛋白質Ｓｉｇｌｅｃ－１５を標的とした抗体 WO2009048072A1 (ja)

Priority Applications (25)

Application Number Priority Date Filing Date Title
CN200880110441.XA CN101896501B (zh) 2007-10-11 2008-10-08 靶向破骨细胞相关蛋白Siglec‑15的抗体
RU2010106639/10A RU2475499C2 (ru) 2007-10-11 2008-10-08 Антитело, направленное на белок siglec-15, связанный с остеокластами
KR1020157004726A KR101577935B1 (ko) 2007-10-11 2008-10-08 파골 세포 관련 단백질 Ｓｉｇｌｅｃ-15 를 표적으로 한 항체
JP2009537006A JPWO2009048072A1 (ja) 2007-10-11 2008-10-08 破骨細胞関連蛋白質Ｓｉｇｌｅｃ−１５を標的とした抗体
BRPI0818437A BRPI0818437B8 (pt) 2007-10-11 2008-10-08 anticorpo ou fragmento funcional do anticorpo, composição farmacêutica, uso de pelo menos um dos anticorpos ou fragmentos funcionais dos anticorpos, e, hibridoma
KR1020107005095A KR101534884B1 (ko) 2007-10-11 2008-10-08 파골 세포 관련 단백질 Ｓｉｇｌｅｃ-15 를 표적으로 한 항체
NZ583397A NZ583397A (en) 2007-10-11 2008-10-08 ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN Siglec-15
CA2698326A CA2698326C (en) 2007-10-11 2008-10-08 Antibody targeting osteoclast-related protein siglec-15
ES08838427.6T ES2540733T3 (es) 2007-10-11 2008-10-08 Anticuerpo que se dirige a la proteína Siglec-15 relacionada con osteoclastos
AU2008311698A AU2008311698C1 (en) 2007-10-11 2008-10-08 Antibody targeting osteoclast-related protein Siglec-15
SI200831433T SI2206727T1 (sl) 2007-10-11 2008-10-08 Protitelo, ki cilja osteoklast - soroden protein Siglec-15
DK08838427.6T DK2206727T3 (en) 2007-10-11 2008-10-08 ANTIBODY SPECIFIC TO OSTEOKLASTRELATERET PROTEIN Siglec-15
PL08838427T PL2206727T3 (pl) 2007-10-11 2008-10-08 Przeciwciało skierowane na białko Siglec-15 związane z osteoklastami
MX2010003884A MX2010003884A (es) 2007-10-11 2008-10-08 Anticuerpo dirigido a la proteina lecitina similar a inmunoglobulina de union a acido sialico-15 relacionado con osteoclastos.
US12/677,621 US8546540B2 (en) 2007-10-11 2008-10-08 Antibody targeting osteoclast-related protein Siglec-15
EP08838427.6A EP2206727B1 (en) 2007-10-11 2008-10-08 ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN Siglec-15
IL204607A IL204607A (en) 2007-10-11 2010-03-18 Anti-protein 15 siglec antagonists - osteoclast-related preparations containing them and their uses
HK11100127.3A HK1145847A1 (en) 2007-10-11 2011-01-07 Antibody targeting osteoclast-related protein siglec-15 siglec-15
AU2012201263A AU2012201263B9 (en) 2007-10-11 2012-02-27 Antibody targeting osteoclast-related protein Siglec-15
US13/457,967 US9090692B2 (en) 2007-10-11 2012-04-27 Antibody targeting osteoclast-related protein Siglec-15
US13/481,016 US10723800B2 (en) 2007-10-11 2012-05-25 Antibody targeting osteoclast-related protein siglec-15
IL234078A IL234078B (en) 2007-10-11 2014-08-12 Polynucleotides encoding antibodies against osteoclast-associated protein Siglec-15
HRP20150485TT HRP20150485T1 (en) 2007-10-11 2015-05-05 ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN Siglec-15
US14/826,515 US9815899B2 (en) 2007-10-11 2015-08-14 Antibody targeting osteoclast-related protein siglec-15
US15/729,947 US10308715B2 (en) 2007-10-11 2017-10-11 Antibody targeting osteoclast-related protein Siglec-15

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-265420 2007-10-11
JP2007265420 2007-10-11

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US12/677,621 A-371-Of-International US8546540B2 (en) 2007-10-11 2008-10-08 Antibody targeting osteoclast-related protein Siglec-15
US13/457,967 Continuation US9090692B2 (en) 2007-10-11 2012-04-27 Antibody targeting osteoclast-related protein Siglec-15
US13/481,016 Continuation US10723800B2 (en) 2007-10-11 2012-05-25 Antibody targeting osteoclast-related protein siglec-15

Publications (1)

Publication Number Publication Date
WO2009048072A1 true WO2009048072A1 (ja) 2009-04-16

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ID=40549216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068287 WO2009048072A1 (ja) 2007-10-11 2008-10-08 破骨細胞関連蛋白質Ｓｉｇｌｅｃ－１５を標的とした抗体

Country Status (25)

Country Link
US (5) US8546540B2 (ja)
EP (2) EP2907826B1 (ja)
JP (4) JPWO2009048072A1 (ja)
KR (2) KR101577935B1 (ja)
CN (2) CN101896501B (ja)
AU (2) AU2008311698C1 (ja)
BR (1) BRPI0818437B8 (ja)
CA (2) CA2875310A1 (ja)
CY (1) CY1116432T1 (ja)
DK (1) DK2206727T3 (ja)
ES (2) ES2540733T3 (ja)
HK (2) HK1209135A1 (ja)
HR (1) HRP20150485T1 (ja)
HU (1) HUE025262T2 (ja)
IL (2) IL204607A (ja)
MX (1) MX2010003884A (ja)
NZ (1) NZ583397A (ja)
PL (1) PL2206727T3 (ja)
PT (1) PT2206727E (ja)
RU (2) RU2475499C2 (ja)
SG (2) SG10201605897RA (ja)
SI (1) SI2206727T1 (ja)
TW (1) TWI511740B (ja)
WO (1) WO2009048072A1 (ja)
ZA (1) ZA201001339B (ja)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010117011A1 (ja) 2009-04-09 2010-10-14 第一三共株式会社 抗Ｓｉｇｌｅｃ－１５抗体
US7989160B2 (en) 2006-02-13 2011-08-02 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling
WO2012045481A2 (en) 2010-10-05 2012-04-12 Daiichi Sankyo Company, Limited Antibody targeting osteoclast-related protein siglec-15
WO2012050154A1 (ja) * 2010-10-13 2012-04-19 学校法人 東京女子医科大学 抗vdac抗体を含有する破骨細胞形成抑制剤
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
WO2013147213A1 (ja) 2012-03-30 2013-10-03 第一三共株式会社 ＣＤＲ改変抗Ｓｉｇｌｅｃ－１５抗体
WO2013147212A1 (ja) 2012-03-30 2013-10-03 第一三共株式会社 新規抗Ｓｉｇｌｅｃ－１５抗体
JP2014527804A (ja) * 2011-09-09 2014-10-23 メディミューン リミテッド 抗Ｓｉｇｌｅｃ−１５抗体およびその使用
US8980272B2 (en) 2004-02-12 2015-03-17 Sankyo Company, Limited Antibody targeting osteoclast-associated protein
WO2015046505A1 (ja) 2013-09-30 2015-04-02 第一三共株式会社 抗ｌｐｓ ｏ１１抗体
US9493562B2 (en) 2012-07-19 2016-11-15 Alethia Biotherapeutics Inc. Anti-Siglec-15 antibodies
US9815899B2 (en) 2007-10-11 2017-11-14 Daiichi Sankyo Company, Limited Antibody targeting osteoclast-related protein siglec-15
WO2018147245A1 (ja) 2017-02-07 2018-08-16 第一三共株式会社 抗ｇｐｒｃ５ｄ抗体及び該抗体を含む分子
WO2018181656A1 (ja) 2017-03-30 2018-10-04 第一三共株式会社 抗ｇｐｒ２０抗体
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