WO2009031565A1 - アミノ酸生産微生物及びアミノ酸の製造法 - Google Patents

アミノ酸生産微生物及びアミノ酸の製造法 Download PDF

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Publication number
WO2009031565A1
WO2009031565A1 PCT/JP2008/065834 JP2008065834W WO2009031565A1 WO 2009031565 A1 WO2009031565 A1 WO 2009031565A1 JP 2008065834 W JP2008065834 W JP 2008065834W WO 2009031565 A1 WO2009031565 A1 WO 2009031565A1
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WIPO (PCT)
Prior art keywords
amino acid
producing
medium
microorganism
microbial cells
Prior art date
Application number
PCT/JP2008/065834
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English (en)
French (fr)
Inventor
Masaru Terashita
Yoshihiro Usuda
Kazuhiko Matsui
Tatyana Abramovna Yampolskaya
Natalia Viktorovna Stoynova
Natalia Sergeevna Eremina
Irina Borisovna Altman
Leonid Romanovich Ptitsyn
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2007228733A external-priority patent/JP2010263790A/ja
Priority claimed from RU2007147434/13A external-priority patent/RU2395579C2/ru
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to EP08829698.3A priority Critical patent/EP2192170B1/en
Priority to BRPI0816429A priority patent/BRPI0816429A2/pt
Priority to CN200880105639.9A priority patent/CN101939412B/zh
Publication of WO2009031565A1 publication Critical patent/WO2009031565A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Ｌ-リジン、Ｌ－スレオニン、Ｌ-トリプトファン、Ｌ-フェニルアラニン、Ｌ-バリン、Ｌ-ロイシン、Ｌ-イソロイシン、及びＬ-セリンからなる群より選ばれるＬ－アミノ酸生産能を有し、かつピルビン酸シンターゼ、または、ピルビン酸：ＮＡＤＰ+オキシドレダクターゼの活性が増大するように改変された微生物を培地、例えばエタノールまたは脂肪酸を炭素源として含む培地で培養して、前記Ｌ-アミノ酸を該培地中又は菌体内に生成蓄積させ、該培地又は菌体よりＬ-アミノ酸を採取する。                               
PCT/JP2008/065834 2007-09-04 2008-09-03 アミノ酸生産微生物及びアミノ酸の製造法 WO2009031565A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08829698.3A EP2192170B1 (en) 2007-09-04 2008-09-03 Amino acid-producing microorganism and method of producing amino acid
BRPI0816429A BRPI0816429A2 (pt) 2007-09-04 2008-09-03 microorganismo, e, método para a produção de um l-aminoácido.
CN200880105639.9A CN101939412B (zh) 2007-09-04 2008-09-03 生产氨基酸的微生物以及氨基酸的生产方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-228733 2007-09-04
JP2007228733A JP2010263790A (ja) 2007-09-04 2007-09-04 アミノ酸生産微生物及びアミノ酸の製造法
RU2007147434/13A RU2395579C2 (ru) 2007-12-21 2007-12-21 СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
RU2007147434 2007-12-21

Publications (1)

Publication Number Publication Date
WO2009031565A1 true WO2009031565A1 (ja) 2009-03-12

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PCT/JP2008/065834 WO2009031565A1 (ja) 2007-09-04 2008-09-03 アミノ酸生産微生物及びアミノ酸の製造法

Country Status (4)

Country Link
EP (1) EP2192170B1 (ja)
CN (1) CN101939412B (ja)
BR (1) BRPI0816429A2 (ja)
WO (1) WO2009031565A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011013707A1 (ja) 2009-07-29 2011-02-03 味の素株式会社 Ｌ-アミノ酸の製造法
WO2011024555A1 (ja) 2009-08-28 2011-03-03 味の素株式会社 Ｌ－アミノ酸の製造法
WO2011096554A1 (ja) 2010-02-08 2011-08-11 味の素株式会社 変異型ｒｐｓＡ遺伝子及びＬ－アミノ酸の製造法
WO2012077739A1 (ja) 2010-12-10 2012-06-14 味の素株式会社 Ｌ－アミノ酸の製造法
US10563234B2 (en) 2014-06-03 2020-02-18 Ajinomoto Co., Inc. Method for producing L-amino acids

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KR101335853B1 (ko) * 2011-12-01 2013-12-02 씨제이제일제당 (주) Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법
CN103865869B (zh) * 2014-04-03 2017-01-11 天津科技大学 一株产α-酮基丁酸的基因工程菌及其应用
KR101747542B1 (ko) * 2015-10-23 2017-06-15 씨제이제일제당 (주) L-이소루신 생산능을 가지는 코리네박테리움 속 미생물 및 이를 이용하여 l-이소루신을 생산하는 방법
JPWO2020032258A1 (ja) * 2018-08-10 2021-08-12 協和発酵バイオ株式会社 多価不飽和脂肪酸を生産する微生物及び多価不飽和脂肪酸の製造法
CN111019878B (zh) * 2020-01-13 2021-04-16 江南大学 L-苏氨酸产量提高的重组大肠杆菌及其构建方法与应用
CN112695036B (zh) * 2021-03-23 2021-07-06 中国科学院天津工业生物技术研究所 一种天冬氨酸激酶基因表达调控序列及其应用
CN113249347B (zh) * 2021-07-14 2021-11-12 中国科学院天津工业生物技术研究所 丙酮酸脱氢酶的突变体及其用于生产l-氨基酸的方法
CN113913478B (zh) * 2021-11-26 2023-06-02 江南大学 一种发酵黄色短杆菌产l-缬氨酸的方法
EP4296367A1 (en) 2022-06-24 2023-12-27 Arkeon GmbH Method for fermentatively producing norvaline
EP4296354A1 (en) 2022-06-24 2023-12-27 Arkeon GmbH Method for producing amino acids in a bioreactor with methanogenic microorganisms
EP4296369A1 (en) 2022-06-24 2023-12-27 Arkeon GmbH Method for producing amino acids in a bioreactor
EP4296368A1 (en) 2022-06-24 2023-12-27 Arkeon GmbH Method for producing amino acids with methanogenic microorganisms in a bioreactor
KR102636674B1 (ko) * 2022-07-11 2024-02-15 대상 주식회사 L-글루탐산을 생산하는 코리네박테리움 속 변이 미생물 및 이를 이용한 l-글루탐산의 생산 방법
CN116286566A (zh) * 2022-07-13 2023-06-23 南京盛德生物科技研究院有限公司 一种l-高丝氨酸高产菌株及其构建方法和应用

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