WO2006099288A2 - Controlled release formulations of octreotide - Google Patents

Controlled release formulations of octreotide Download PDF

Info

Publication number
WO2006099288A2
WO2006099288A2 PCT/US2006/008891 US2006008891W WO2006099288A2 WO 2006099288 A2 WO2006099288 A2 WO 2006099288A2 US 2006008891 W US2006008891 W US 2006008891W WO 2006099288 A2 WO2006099288 A2 WO 2006099288A2
Authority
WO
WIPO (PCT)
Prior art keywords
octreotide
formulation
controlled release
months
release formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/008891
Other languages
English (en)
French (fr)
Other versions
WO2006099288A3 (en
Inventor
Petr Kuzma
Stephanie Decker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valera Pharmaceuticals Inc
Indevus Pharmaceuticals Inc
Original Assignee
Valera Pharmaceuticals Inc
Indevus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020077023359A priority Critical patent/KR101399911B1/ko
Priority to NZ561400A priority patent/NZ561400A/en
Priority to EP06738004A priority patent/EP1888043A4/en
Priority to CA2601304A priority patent/CA2601304C/en
Priority to AU2006223161A priority patent/AU2006223161B2/en
Priority to EA200701956A priority patent/EA015793B1/ru
Priority to JP2008501025A priority patent/JP4584331B2/ja
Application filed by Valera Pharmaceuticals Inc, Indevus Pharmaceuticals Inc filed Critical Valera Pharmaceuticals Inc
Publication of WO2006099288A2 publication Critical patent/WO2006099288A2/en
Publication of WO2006099288A3 publication Critical patent/WO2006099288A3/en
Priority to IL185800A priority patent/IL185800A0/en
Anticipated expiration legal-status Critical
Priority to NO20074628A priority patent/NO20074628L/no
Priority to AU2011201460A priority patent/AU2011201460B2/en
Priority to AU2011201471A priority patent/AU2011201471B2/en
Priority to AU2011201457A priority patent/AU2011201457B2/en
Priority to IL214617A priority patent/IL214617A/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Definitions

  • LH gonadotropin releasing hormone
  • GnRH gonadotropin releasing hormone
  • GH levels fall within one hour and headaches improve within minutes after the injection of octreotide.
  • octreotide is effective for long-term treatment.
  • Octreotide also has been used successfully to treat patients with acromegaly caused by non-pituitary tumors. In some acromegaly patients who already have diabetes, octreotide can reduce the need for insulin and improve blood sugar control.
  • PT #250608 v4 (5ddcO4I.DOC) acromegaly, diabetes, severe diarrhea and flushing episodes associated with carcinoid tumors and watery diarrhea associated with VIPomas.
  • a method of treating a patient comprising administering a controlled release formulation of octreotide.
  • the controlled release formulation maintains an in vivo average C ss of about 0.1 ng/ml to about 9 ng/ml of octreotide in a patient in need thereof.
  • Fig. 1 is a graph showing the linear relationship between the equilibrium water content vs. the weight percent content of hydroxypropyl methacrylate (HPMA) units in crosslinked HEMA/HPMA polymers at their maximum state of hydration.
  • HPMA hydroxypropyl methacrylate
  • Fig. 7 is a graph showing octreotide and IGF-I serum levels in a group of 3 healthy dogs implanted with one octreotide implant formulation of the present invention over a six month period.
  • Fig. 10 is a graph depicting octreotide serum levels in eleven human subjects with acromegaly over six months implanted with an octreotide formulation of the present invention.
  • the term "about” means plus or minus 10% of the numerical value of the number with which it is being used. For example, about 50% means in the range of45%-55%.
  • HPMA unit(s) is meant the structure
  • Another aspect is a therapeutic composition of a hydrogel and octreotide, wherein, upon implantation, the octreotide is released at a rate that provides and/or maintains a C ss of about 0.1 ng/ml to about 9 ng/ml, preferably about 1 ng/ml to about 2 ng/ml, more preferably about 1.2 ng/ml to about 1.6 ng/ml.
  • Diluents that are suitable for use in the pharmaceutical composition of the present invention include, for example, pharmaceutically acceptable inert fillers such as microcrystalline cellulose, lactose, sucrose, fructose, glucose dextrose, or other sugars, dibasic calcium phosphate, calcium sulfate, cellulose, ethylcellulose, cellulose derivatives,
  • pharmaceutically acceptable inert fillers such as microcrystalline cellulose, lactose, sucrose, fructose, glucose dextrose, or other sugars, dibasic calcium phosphate, calcium sulfate, cellulose, ethylcellulose, cellulose derivatives,
  • Glidants are used to improve the flow and compressibility of ingredients during processing.
  • Suitable glidants include, for example, colloidal silicon dioxide, a sub- micron fumed silica that can be prepared by, for example, vapor-phase hydrolysis of a silicon compound such as silicon tetrachloride.
  • Colloidal silicon dioxide is a sub-micron amorphous powder which is commercially available from a number of sources, including Cabot Corporation (under the tradename Cab-O-Sil); Degussa, Inc. (under the tradename Aerosil); and E.I. DuPont & Co.
  • Colloidal silicon dioxide is also known as colloidal silica, fumed silica, light anhydrous silicic acid, silicic anhydride, and silicon dioxide fumed, among others.
  • the glidant comprises Aerosil 200.
  • Another agent that may be used is a surfactant, dissolution agent and other solubilizing material.
  • Surfactants that are suitable for use in the pharmaceutical composition of the present invention include, for example, sodium lauryl sulphate, polyethylene stearates, polyethylene sorbitan fatty acid esters, polyoxyethylene castor oil derivatives, polyoxyethylene alkyl ethers, benzyl benzoate, cetrimide, cetyl alcohol, docusate sodium, glyceryl monooleate, glyceryl monostearate, glyceryl palmitostearate, lecithin, medium chain
  • compositions of the present invention may be used for the treatment of hormonal diseases characterized by increased levels of GH and IGF-I by administering to a patient an implantable formulation of the present invention.
  • the implant is administered every about six months, and releases a therapeutically effective amount of octreotide, preferably octreotide acetate.
  • the implantable composition releases a concentration of octreotide in the patient at about the minimum therapeutically effective level to ameliorate the hormonal disorder, yet relatively lower compared to the maximum concentration in order to enhance restful periods for the patient during the day.
  • PT: #250608 v4 (5ddc04!.DOC) of GH and IGF-I were measured at baseline and every month thereafter for a period of six months.
  • Each implant contained approximately 60 mg of octreotide acetate in a copolymer of 20% HEMA and 79.5% HPMA, with an EWC of about 25.2%.
  • the implants used in this study were about 44 mm in length in a dry state and 50 mm in length in a hydrated state.
  • the diameters of the implants were about 2.8 mm in a dry state and about 3.5 to about 3.6 mm in a hydrated state.
  • the implants were hydrated for a period of about 1 week prior to implantation.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/US2006/008891 2005-03-11 2006-03-10 Controlled release formulations of octreotide Ceased WO2006099288A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
KR1020077023359A KR101399911B1 (ko) 2005-03-11 2006-03-10 옥트레오타이드의 방출 조절형 제형
NZ561400A NZ561400A (en) 2005-03-11 2006-03-10 Controlled release formulations of octreotide
EP06738004A EP1888043A4 (en) 2005-03-11 2006-03-10 OCTREOTIDE FORMULATIONS WITH CONTROLLED RELEASE
CA2601304A CA2601304C (en) 2005-03-11 2006-03-10 Controlled release formulations of octreotide
AU2006223161A AU2006223161B2 (en) 2005-03-11 2006-03-10 Controlled release formulations of octreotide
EA200701956A EA015793B1 (ru) 2005-03-11 2006-03-10 Способ лечения акромегалии и связанных с ней симптомов и имплант, применяемый в этом способе
JP2008501025A JP4584331B2 (ja) 2005-03-11 2006-03-10 オクトレオチドの放出制御製剤
IL185800A IL185800A0 (en) 2005-03-11 2007-09-06 Controlled release formulations of octreotide
NO20074628A NO20074628L (no) 2005-03-11 2007-09-12 Formuleringer av octreotid med kontrollert frigjoring
AU2011201457A AU2011201457B2 (en) 2005-03-11 2011-03-31 Controlled release formulations of octreotide
AU2011201460A AU2011201460B2 (en) 2005-03-11 2011-03-31 Controlled release formulations of octreotide
AU2011201471A AU2011201471B2 (en) 2005-03-11 2011-03-31 Controlled release formulations of octreotide
IL214617A IL214617A (en) 2005-03-11 2011-08-11 Use of controlled release formulations of octreotide for the preparation of implants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66093005P 2005-03-11 2005-03-11
US60/660,930 2005-03-11

Publications (2)

Publication Number Publication Date
WO2006099288A2 true WO2006099288A2 (en) 2006-09-21
WO2006099288A3 WO2006099288A3 (en) 2007-03-01

Family

ID=36992335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/008891 Ceased WO2006099288A2 (en) 2005-03-11 2006-03-10 Controlled release formulations of octreotide

Country Status (13)

Country Link
US (8) US7452868B2 (enExample)
EP (3) EP1888043A4 (enExample)
JP (2) JP4584331B2 (enExample)
KR (1) KR101399911B1 (enExample)
CN (2) CN103550137B (enExample)
AU (4) AU2006223161B2 (enExample)
CA (1) CA2601304C (enExample)
EA (1) EA015793B1 (enExample)
IL (2) IL185800A0 (enExample)
NO (1) NO20074628L (enExample)
NZ (1) NZ561400A (enExample)
UA (1) UA89398C2 (enExample)
WO (1) WO2006099288A2 (enExample)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010039643A1 (en) * 2008-09-30 2010-04-08 Endo Pharmaceuticals Solutions Inc. Implantable device for the delivery of histrelin and methods of use thereof
WO2010039717A1 (en) * 2008-09-30 2010-04-08 Endo Pharmaceuticals Solutions Inc. Implantable device for the delivery of octreotide and methods of use thereof
WO2009158412A3 (en) * 2008-06-25 2010-07-15 Endo Pharmaceuticals Solutions Inc. Sustained delivery of exenatide and other polypeptides
US7759312B2 (en) 2005-03-11 2010-07-20 Endo Pharmaceuticals Solutions Inc. Delivery of dry formulations of octreotide
JP2010524652A (ja) * 2007-04-27 2010-07-22 エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド． インプラントデバイス離型剤及びその使用法
US7803773B2 (en) 2005-03-11 2010-09-28 Endo Pharmaceuticals Solutions Inc. Controlled release formulations of octreotide
US7842303B2 (en) 2003-08-11 2010-11-30 Indevus Pharmaceuticals, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
US7858110B2 (en) 2003-08-11 2010-12-28 Endo Pharmaceuticals Solutions, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
US7960335B2 (en) 2008-06-25 2011-06-14 Endo Pharmaceuticals Solutions Inc. Octreotide implant having a release agent and uses thereof
US8062652B2 (en) 2004-06-17 2011-11-22 Endo Pharmaceuticals Solutions Inc. Compositions and methods for treating precocious puberty
US9078900B2 (en) 2008-09-30 2015-07-14 Braeburn Pharmaceuticals Bvba Sprl Implantable device for the delivery of risperidone and methods of use thereof

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006065951A2 (en) * 2004-12-15 2006-06-22 Qlt Usa, Inc. Sustained delivery formulations of octreotide compounds
JP5276982B2 (ja) 2005-08-26 2013-08-28 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ オキシトシンの投与による頭痛の処置のための方法
US20080286325A1 (en) * 2006-01-05 2008-11-20 Med Institute, Inc. Cyclodextrin elution media for medical device coatings comprising a taxane therapeutic agent
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20100196264A1 (en) * 2007-05-18 2010-08-05 The Brigham And Women's Hospital, Inc. Use of somatostatin analogs in myocardial perfusion imaging
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2009148583A2 (en) * 2008-06-03 2009-12-10 Qlt Usa, Inc. Method for improvement of octreotide bioavailability
US20090325863A1 (en) * 2008-06-13 2009-12-31 Kleinberg David L Somatostatin analogs and IGF-I inhibition for breast cancer prevention
RU2678833C2 (ru) 2008-09-17 2019-02-04 Киазма Инк. Фармацевтические композиции и соответствующие способы доставки
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーＳｐｏｔｌｉｇｈｔ Ｔｅｃｈｎｏｌｏｇｙ Ｐａｒｔｎｅｒｓ Ｌｌｃ 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
AU2010314994B2 (en) 2009-11-09 2016-10-06 Spotlight Technology Partners Llc Fragmented hydrogels
WO2012074559A2 (en) 2010-12-02 2012-06-07 New York University Treatment of non-proliferative cystic disease
TWI583401B (zh) 2011-10-24 2017-05-21 布雷本製藥股份有限公司 可植入替紮尼定組合物及其治療方法
US10646552B2 (en) 2012-01-17 2020-05-12 Tyme, Inc. Pharmaceutical compositions and methods
US8481498B1 (en) 2012-01-17 2013-07-09 Steven Hoffman Pharmaceutical compositions and methods
US20130183263A1 (en) 2012-01-17 2013-07-18 Steven Hoffman Pharmaceutical compositions and methods
US10272068B2 (en) 2012-01-17 2019-04-30 Tyme, Inc. Pharmaceutical compositions and methods
DK3007704T3 (da) * 2013-06-13 2021-03-29 Antisense Therapeutics Ltd Kombinationsterapi til akromegali
US9585841B2 (en) 2013-10-22 2017-03-07 Tyme, Inc. Tyrosine derivatives and compositions comprising them
JP2016534064A (ja) 2013-10-22 2016-11-04 プロリンクス エルエルシー ソマトスタチン及びその類似体のコンジュゲート
US10813901B2 (en) 2013-10-22 2020-10-27 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
US10751313B2 (en) 2013-10-22 2020-08-25 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
US9763903B2 (en) 2013-10-22 2017-09-19 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US9326962B2 (en) 2013-10-22 2016-05-03 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
PL3242676T3 (pl) 2015-01-07 2024-07-15 Tonix Pharma Limited Preparaty oksytocyny zawierające magnez i sposoby ich stosowania
SI3253401T1 (sl) 2015-02-03 2025-07-31 Amryt Endo, Inc. Zdravljenje akromegalije z oralnim oktreotidom
HRP20250215T1 (hr) 2016-04-12 2025-06-20 Tonix Pharma Limited Formulacije oksitocina koje sadrže magnezij i postupci upotrebe
JP2021530568A (ja) 2018-07-19 2021-11-11 ヤモ・ファーマシューティカルズ・エルエルシー 自閉症を処置するための組成物および方法
CN111214643A (zh) * 2020-03-11 2020-06-02 苏州善湾生物医药科技有限公司 一种基于皮下凝胶缓释的奥曲肽组合物、制备方法及应用
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods
US20250152674A1 (en) * 2022-02-25 2025-05-15 Amryt Endo, Inc. Oral octreotide for treatment of disease
AU2024248975A1 (en) * 2023-03-27 2025-11-13 Cellular Longevity, Inc. Pharmaceutical formulations for longevity in mammals
IL328013A (en) * 2023-11-01 2026-06-01 Entrega Inc Oral dosage form with ionically chargeable hydrogel for delivery of active agent and permeation enhancer
WO2026006394A1 (en) * 2024-06-26 2026-01-02 Loyal Animal Health, Inc. Somatostatin analogs and compositions and uses thereof
US20260096905A1 (en) * 2024-10-07 2026-04-09 Pituvia Therapeutics, Inc. Implantable drug-device combinations, and related methods of treatment

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US71736A (en) * 1867-12-03 Improvement in fences
US2168331A (en) 1936-10-17 1939-08-08 Du Pont Cast resin with integral sheen
US2513014A (en) * 1946-11-18 1950-06-27 Abbott Lab Apparatus for implanting medicinal pellets subcutaneously
GB1306541A (en) 1969-01-20 1973-02-14 Ceskoslovenska Akademie Ved Method of manufacturing tubes by centrifugal casting
US3772435A (en) 1971-11-02 1973-11-13 American Cyanamid Co Method of using steroid acetonides as growth promoting agents
US3975350A (en) 1972-08-02 1976-08-17 Princeton Polymer Laboratories, Incorporated Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles
US3921632A (en) * 1974-08-16 1975-11-25 Frank M Bardani Implant device
US4131604A (en) 1977-11-23 1978-12-26 Thermo Electron Corporation Polyurethane elastomer for heart assist devices
US4285987A (en) * 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
US4298002A (en) 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4386039A (en) 1980-02-11 1983-05-31 Thermo Electron Corporation Process for forming an optically clear polyurethane lens or cornea
US4523005A (en) 1981-10-30 1985-06-11 Thermedics, Inc. Extrudable polyurethane for prosthetic devices prepared from a diisocyanate, a polytetramethylene ether polyol, and 1,4-butane diol
US4751133A (en) 1984-11-13 1988-06-14 Thermedics, Inc. Medical patches and processes for producing same
US5342622A (en) * 1986-05-16 1994-08-30 The State Of Victoria Subdermal biocompatible implants
US4959217A (en) * 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US4743673A (en) 1986-12-19 1988-05-10 Tyndale Plains-Hunter, Ltd. Hydrophilic carboxy polyurethanes
US4871094A (en) 1986-12-31 1989-10-03 Alcon Laboratories, Inc. Means and method for dispensing substances
US4846793A (en) * 1987-03-18 1989-07-11 Endocon, Inc. Injector for implanting multiple pellet medicaments
US4994028A (en) * 1987-03-18 1991-02-19 Endocon, Inc. Injector for inplanting multiple pellet medicaments
AU608891B2 (en) 1987-09-24 1991-04-18 Merck & Co., Inc. Solubility modulated drug delivery device
US5035891A (en) 1987-10-05 1991-07-30 Syntex (U.S.A.) Inc. Controlled release subcutaneous implant
US4954587A (en) * 1988-07-05 1990-09-04 Ciba-Geigy Corporation Dimethylacrylamide-copolymer hydrogels with high oxygen permeability
GB8820353D0 (en) * 1988-08-26 1988-09-28 Staniforth J N Controlled release tablet
HU207940B (en) 1989-02-16 1993-07-28 British Tech Group Feeder apparatus for controlled dissolution of the active components
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US5538739A (en) 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
US5273752A (en) * 1989-07-18 1993-12-28 Alza Corporation Controlled release dispenser comprising beneficial agent
US5468811A (en) * 1989-11-02 1995-11-21 National Patent Development Corporation Hydrophilic composite polymer articles formed from a settable paste comprising a mixture of hydrophilic polymer and unsaturated monomer
US5254662A (en) 1990-09-12 1993-10-19 Polymedia Industries, Inc. Biostable polyurethane products
US5266325A (en) * 1990-09-28 1993-11-30 Hydro Med Science Division Of National Patent Development Corp. Preparation of homogeneous hydrogel copolymers
AU651654B2 (en) 1992-01-14 1994-07-28 Endo Pharmaceuticals Solutions Inc. Manufacture of water-swellable hydrophilic articles and drug delivery devices
ATE106015T1 (de) * 1990-09-28 1994-06-15 Pfizer Wirkstoffabgabevorrichtung die ein hydrophobisches mittel enthält.
HU222249B1 (hu) * 1991-03-08 2003-05-28 Amylin Pharmaceuticals Inc. Eljárás amilin agonista peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
AU652984B2 (en) 1992-01-14 1994-09-15 Endo Pharmaceuticals Solutions Inc. Preparation of homogeneous hydrogel copolymers
JP2530079B2 (ja) * 1992-02-05 1996-09-04 ナショナル・パテント・ディベロプメント・コーポレーション 水分膨潤性親水性製品及び薬物放出装置の製造
EP0637323B1 (en) * 1992-04-24 1998-08-19 The Polymer Technology Group, Inc. Copolymers and non-porous, semi-permeable membrane thereof and its use for permeating molecules of predetermined molecular weight range
US5614223A (en) * 1992-05-04 1997-03-25 Digestive Care Inc. Intraoral medicament-releasing device
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
EP0628959B1 (en) * 1993-06-11 2000-09-06 Nippon Chemi-Con Corporation Apparatus for supporting and connecting a magnetic field modulation head to be used for a photomagnetic recording
US5354835A (en) 1993-07-23 1994-10-11 Saudi Basic Industries Corporation Desalination process
JPH07252166A (ja) * 1993-09-20 1995-10-03 Shiseido Co Ltd 徐放性製剤
KR950007873A (ko) 1993-09-20 1995-04-15 후꾸하라 요시하루 생리 활성 물질 지속 방출형의 의약 제제
JPH0797338A (ja) * 1993-09-20 1995-04-11 Shiseido Co Ltd 徐放性製剤
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US6143718A (en) * 1995-06-07 2000-11-07 Amylin Pharmaceuticals, Inc. Treatment of Type II diabetes mellutis with amylin agonists
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
CA2264562C (en) * 1996-08-30 2012-01-03 Peptech Limited Sustained peptide-release formulation
US5945128A (en) * 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
AUPO251096A0 (en) 1996-09-23 1996-10-17 Cardiac Crc Nominees Pty Limited Polysiloxane-containing polyurethane elastomeric compositions
US5756127A (en) * 1996-10-29 1998-05-26 Wright Medical Technology, Inc. Implantable bioresorbable string of calcium sulfate beads
JP4798814B2 (ja) * 1997-01-07 2011-10-19 アミリン・ファーマシューティカルズ，インコーポレイテッド 食物摂取低減用のエキセンジンおよびそのアゴニストの使用
US5854127A (en) * 1997-03-13 1998-12-29 Micron Technology, Inc. Method of forming a contact landing pad
FI971385A0 (fi) 1997-04-04 1997-04-04 Bioxid Oy Biokompatibel komposition, metoder foer dess framstaellning samt anvaendning daerav
US7101853B2 (en) * 1997-05-06 2006-09-05 Amylin Pharmaceuticals, Inc. Method for treating or preventing gastritis using amylin or amylin agonists
US7157555B1 (en) * 1997-08-08 2007-01-02 Amylin Pharmaceuticals, Inc. Exendin agonist compounds
US7220721B1 (en) * 1997-11-14 2007-05-22 Amylin Pharmaceuticals, Inc. Exendin agonist peptides
US6770623B1 (en) * 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
US6822016B2 (en) 2001-09-10 2004-11-23 Johnson & Johnson Vision Care, Inc. Biomedical devices containing internal wetting agents
AU4992299A (en) * 1998-07-14 2000-02-07 Amylin Pharmaceuticals, Inc. Uncoupling protein 4 (ucp-4) and methods of use
US6087334A (en) * 1998-08-21 2000-07-11 Amylin Pharmaceuticals, Inc. Anti-diabetic peptides
US20040071736A1 (en) * 1998-08-25 2004-04-15 Health Protection Agency Methods and compounds for the treatment of mucus hypersecretion
US7259136B2 (en) * 1999-04-30 2007-08-21 Amylin Pharmaceuticals, Inc. Compositions and methods for treating peripheral vascular disease
JP2002538084A (ja) * 1999-01-14 2002-11-12 アミリン・ファーマシューティカルズ，インコーポレイテッド グルカゴンを抑制する方法
CA2325386C (en) * 1999-01-28 2010-03-23 Hydromed Sciences A Division Of Gp Strategies Corporation Hydrogel compositions useful for the sustained release of macromolecules and methods of making same
WO2001051078A1 (en) * 2000-01-10 2001-07-19 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia
CN1487836A (zh) * 2000-03-14 2004-04-07 埃米林药品公司 胰高糖素样肽1(7-36)对胃窦幽门十二指肠能动性的影响
US6969480B2 (en) * 2000-05-12 2005-11-29 Matregen Corp. Method of producing structures using centrifugal forces
AU2001263230B2 (en) * 2000-05-19 2005-03-10 Amylin Pharmaceuticals, Llc Treatment of acute coronary syndrome with glp-1
JP3498041B2 (ja) * 2000-05-29 2004-02-16 科研製薬株式会社 プラルモレリン含有点鼻用製剤
US7118737B2 (en) * 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
EP2123293A3 (en) * 2000-12-14 2010-09-08 Amylin Pharmaceuticals, Inc. Peptide YY and petide YY agonists for treatment of metabolic disorders
US20030049320A1 (en) * 2000-12-18 2003-03-13 Wockhardt Limited Novel in-situ forming controlled release microcarrier delivery system
WO2002078597A2 (en) 2001-04-01 2002-10-10 Yeda Research And Development Co. Ltd. Weizmann Institute Of Science Oral absorbed drugs
US7105489B2 (en) * 2002-01-22 2006-09-12 Amylin Pharmaceuticals, Inc. Methods and compositions for treating polycystic ovary syndrome
DE10208335A1 (de) * 2002-02-27 2003-09-04 Roehm Gmbh Arzneiform und Verfahren zu ihrer Herstellung
US20060122106A1 (en) * 2002-06-14 2006-06-08 Amylin Pharmaceuticals, Inc Prevention and/or treatment of inflammatory bowel disease using pyy or agonists thereof
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
US6942264B1 (en) * 2003-02-10 2005-09-13 Richard Mendez Disposable pet waste receptacle
CA2437639C (en) * 2003-08-11 2016-07-05 Valera Pharmaceuticals, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
WO2005041873A2 (en) 2003-10-24 2005-05-12 Azopax Therapeutics Llc Formulation of exendin-4
US20050143303A1 (en) 2003-12-26 2005-06-30 Nastech Pharmaceutical Company Inc. Intranasal administration of glucose-regulating peptides
US8076288B2 (en) * 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
WO2006009801A2 (en) * 2004-06-17 2006-01-26 Valera Pharmaceuticals, Inc. Compositions and methods for treating central precocious puberty
SE0402345L (sv) * 2004-09-24 2006-03-25 Mederio Ag Uppmätt läkemedelsdos
WO2006099288A2 (en) 2005-03-11 2006-09-21 Indevus Pharmaceuticals, Inc. Controlled release formulations of octreotide
US7759312B2 (en) * 2005-03-11 2010-07-20 Endo Pharmaceuticals Solutions Inc. Delivery of dry formulations of octreotide
US20070037897A1 (en) 2005-08-12 2007-02-15 Guigui Wang Method for making contact lenses
JP2009507050A (ja) 2005-09-08 2009-02-19 ガストロテック・ファルマ・アクティーゼルスカブ 胆道ジスキネジーおよび／または胆道痛／不快の治療のためのｇｌｐ−１分子の使用
WO2008061355A1 (en) 2006-11-24 2008-05-29 Matregen Corp. Glp-1 depot systems, and methods of manufacture and uses thereof
RU2463079C2 (ru) 2007-04-27 2012-10-10 Эндо Фармасьютикалз Солюшнз Инк. Разделительные агенты для имплантируемого устройства и способы их применения
EP2317975B1 (en) * 2008-06-25 2016-04-13 Endo Pharmaceuticals Solutions Inc. Octreotide implant having a release agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of EP1888043A4 *

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8343528B2 (en) 2003-08-11 2013-01-01 Endo Pharmaceuticals Solutions Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
US8658195B2 (en) 2003-08-11 2014-02-25 Endo Pharmaceuticals Solutions Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
US8529936B2 (en) 2003-08-11 2013-09-10 Endo Pharmaceuticals Solutions Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
US8357389B2 (en) 2003-08-11 2013-01-22 Endo Pharmaceuticals Solutions Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
US7858110B2 (en) 2003-08-11 2010-12-28 Endo Pharmaceuticals Solutions, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
US7842303B2 (en) 2003-08-11 2010-11-30 Indevus Pharmaceuticals, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
US8062652B2 (en) 2004-06-17 2011-11-22 Endo Pharmaceuticals Solutions Inc. Compositions and methods for treating precocious puberty
US7759312B2 (en) 2005-03-11 2010-07-20 Endo Pharmaceuticals Solutions Inc. Delivery of dry formulations of octreotide
US7803773B2 (en) 2005-03-11 2010-09-28 Endo Pharmaceuticals Solutions Inc. Controlled release formulations of octreotide
KR101574354B1 (ko) * 2007-04-27 2015-12-04 엔도 파마슈티컬즈, 솔루션스 아이엔씨. 이식 장치 이형제 및 이의 사용 방법
JP2010524652A (ja) * 2007-04-27 2010-07-22 エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド． インプラントデバイス離型剤及びその使用法
JP2016006098A (ja) * 2007-04-27 2016-01-14 エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド．Ｅｎｄｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｓｏｌｕｔｉｏｎｓ Ｉｎｃ． インプラントデバイス離型剤及びその使用法
US9120249B2 (en) 2007-04-27 2015-09-01 Endo Pharmaceuticals Solutions Inc. Implant device release agents and methods of using same
JP2011526289A (ja) * 2008-06-25 2011-10-06 エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド． 離型剤を有するオクトレオチドインプラント
US9072786B2 (en) 2008-06-25 2015-07-07 Endo Pharmaceuticals Solutions Inc. Method of manufacturing an implantable device
US8383577B2 (en) 2008-06-25 2013-02-26 Endo Pharmaceuticals Solutions, Inc. Octreotide implant having a release agent
US7960335B2 (en) 2008-06-25 2011-06-14 Endo Pharmaceuticals Solutions Inc. Octreotide implant having a release agent and uses thereof
WO2009158412A3 (en) * 2008-06-25 2010-07-15 Endo Pharmaceuticals Solutions Inc. Sustained delivery of exenatide and other polypeptides
US8071537B2 (en) 2008-06-25 2011-12-06 Endo Pharmaceuticals Solutions Inc. Implantable device for the sustained release of a polypeptide
RU2521291C2 (ru) * 2008-06-25 2014-06-27 Эндо Фармасьютикалз Солюшнз Инк. Имплантат октреотида, содержащий высвобождающее вещество
JP2011527705A (ja) * 2008-07-11 2011-11-04 エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド． オクトレオチドの乾燥処方物の送達
US9078900B2 (en) 2008-09-30 2015-07-14 Braeburn Pharmaceuticals Bvba Sprl Implantable device for the delivery of risperidone and methods of use thereof
US8784865B2 (en) 2008-09-30 2014-07-22 Endo Pharmaceuticals Solutions Inc. Long term drug delivery devices with polyurethane-based polymers and their manufacture
US8303977B2 (en) 2008-09-30 2012-11-06 Endo Pharmaceuticals Solutions Inc. Long term drug delivery devices with polyurethane-based polymers and their manufacture
WO2010039717A1 (en) * 2008-09-30 2010-04-08 Endo Pharmaceuticals Solutions Inc. Implantable device for the delivery of octreotide and methods of use thereof
AU2009298711B2 (en) * 2008-09-30 2015-10-29 Endo Pharmaceuticals Solutions Inc. Implantable device for the delivery of octreotide and methods of use thereof
US8460274B2 (en) 2008-09-30 2013-06-11 Endo Pharmaceuticals Solutions Inc. Long term drug delivery devices with polyurethane-based polymers and their manufacture
WO2010039643A1 (en) * 2008-09-30 2010-04-08 Endo Pharmaceuticals Solutions Inc. Implantable device for the delivery of histrelin and methods of use thereof

Also Published As

Publication number Publication date
US20200046806A1 (en) 2020-02-13
US8507432B2 (en) 2013-08-13
AU2006223161B2 (en) 2011-05-12
CA2601304C (en) 2010-08-17
NZ561400A (en) 2010-02-26
WO2006099288A3 (en) 2007-03-01
KR101399911B1 (ko) 2014-06-19
AU2006223161A1 (en) 2006-09-21
AU2011201457B2 (en) 2011-05-19
IL214617A (en) 2016-05-31
AU2011201460A1 (en) 2011-04-21
EP2455072A1 (en) 2012-05-23
IL214617A0 (en) 2011-09-27
AU2011201457A1 (en) 2011-04-21
CN103550137B (zh) 2015-07-29
CA2601304A1 (en) 2006-09-21
AU2011201460B2 (en) 2011-07-28
JP2010189401A (ja) 2010-09-02
JP4584331B2 (ja) 2010-11-17
UA89398C2 (uk) 2010-01-25
US7452868B2 (en) 2008-11-18
US20060204540A1 (en) 2006-09-14
IL185800A0 (en) 2008-01-06
KR20080005496A (ko) 2008-01-14
US7803773B2 (en) 2010-09-28
EP1888043A4 (en) 2010-07-28
NO20074628L (no) 2007-11-27
US20090087470A1 (en) 2009-04-02
CN101193626A (zh) 2008-06-04
EP1888043A2 (en) 2008-02-20
US20250255936A1 (en) 2025-08-14
US20170100461A1 (en) 2017-04-13
JP2008533046A (ja) 2008-08-21
EA015793B1 (ru) 2011-12-30
EA200701956A1 (ru) 2008-02-28
US20200353055A1 (en) 2020-11-12
CN103550137A (zh) 2014-02-05
US20110009338A1 (en) 2011-01-13
EP2457564A1 (en) 2012-05-30
AU2011201471B2 (en) 2011-05-19
US20100317579A1 (en) 2010-12-16
AU2011201471A1 (en) 2011-04-21

Similar Documents

Publication Publication Date Title
US20250255936A1 (en) Controlled release formulations of octreotide
US20190388500A1 (en) Delivery of dry formulations of octreotide
US8383577B2 (en) Octreotide implant having a release agent
US20250249067A1 (en) Delivery of dry formulations of octreotide
HK1121675A (en) Controlled release formulations of octreotide
HK1158491B (en) Octreotide implant having a release agent

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200680016029.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 185800

Country of ref document: IL

ENP Entry into the national phase

Ref document number: 2601304

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2008501025

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 561400

Country of ref document: NZ

Ref document number: 2006223161

Country of ref document: AU

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2006738004

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2006738004

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1563/MUMNP/2007

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 2006223161

Country of ref document: AU

Date of ref document: 20060310

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: RU

WWE Wipo information: entry into national phase

Ref document number: 1020077023359

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 200701956

Country of ref document: EA

WWE Wipo information: entry into national phase

Ref document number: 214617

Country of ref document: IL