US3921632A - Implant device - Google Patents

Implant device Download PDF

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US3921632A
US3921632A US49807974A US3921632A US 3921632 A US3921632 A US 3921632A US 49807974 A US49807974 A US 49807974A US 3921632 A US3921632 A US 3921632A
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Prior art keywords
tubular member
bore
end
plunger
device
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Frank M Bardani
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Frank M Bardani
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069Devices for implanting pellets, e.g. markers or solid medicaments

Abstract

A tubular member has a central longitudinal axial bore therethrough, a pointed elongated annular concavely bevelled implanting end and a charging end. The implanting and charging ends communicate with the bore. A first plunger having a solid pointed elongated annular concavely bevelled implanting end is adapted to be removably inserted in the bore for slidable movement therein. When the first plunger is completely inserted in the bore of the tubular member the implanting ends are aligned to form a complimentary substantially continuous, pointed, elongated, annular concavely bevelled penetration surface. The first plunger is slidably moveable in the bore of the tubular member from a first to a second position at which insertion of the first plunger in the bore is complete. Means are optionally provided for aligning the implanting ends at only the second position.

Description

United States Patent Bardani 1 Nov. 25, 1975 IMPLANT DEVICE Primary Examiner-Robert W. Michell [76] Inventor: Frank M. Bardani, 16 Loewen EmmmerB'ck 0pm Cour" Rye 10580 Attorney, Agent. or Firm-Morton S. Simon, Esq.

[22] Filed: Aug. 16, 1974 21 Appl. No: 498,079 [57] ABSTRACT A tubular member has a central longitudinal axial [52] CL H 128/217; 28/264 bore therethrough, a pointed elongated annular con- [511 ML CH H AGIM 5/00; AlM :HIOO cavely bevelled implanting end and a charging end. [58] Fwd of Search 128/22] 2n 264 218 D The implanting and charging ends communicate with Hag/2M4 347 2 B P 215 the bore. A first plunger having a solid pointed elongated annular concavely bevelled implanting end is [56] References cited adapted to be removably inserted in the bore for slidable movement therein. When the first plunger is com UNITED SUTATES PATENTS pletely inserted in the bore of the tubular member the 2.513.014 6/1950 Fields 128/217 implanting ends are aligned 19 form a Complimentary wfii a g /Z substantially continuous, pointed, elongated, annular 2952'256 9H9) ";i 28/221 concavely bevelled penetration surface The first 2'959:l70 H960 Laub Tb P plunger is slidably moveable in the bore of the tubular 30973347 7 g 3 Roehr l 4 g Q8021 member from a first to a second position at which in- 3,297,031 H1967 Bray... 128/264 Sertion of the first plunger in the bore is complete. 3.585986 6/1971 Kru 128/221 Means are optionally rovided for alignin the im- 8 P g 3.630.192 12/1971 Jamshidi. 128/347 planting ends at only the second position. 3,788,320 1/1974 Dye r 128/221 ll Claims, 4 Drawing Figures U.S. Patent Nov. 25, 1975 IMPLANT DEVICE The present invention relates to an improved device for administration of drugs. More particularly, the invention relates to an improved device for subcutaneous introduction of drug implants, preferably in pellet form.

Techniques and devices for introducing solid medicaments beneath the skin are known to the art. Medical use of drug implants was initiated as early as l86l, see Howard Jones, N., .l. Hist. Med. 2, 20l (1947). Implants have advantageously been used for administration of hormones, such as testosterone, estradiol and other drugs, where slow, constant release and continuous absorption of a drug for prolonged time periods is desired. The long lasting effect of a drug implant frees the patient from the need to take multiple periodic parenteral or oral doses. Implant therapy is often in the long run more economical. Moreover, where a dosage regimen is critical use of implants eliminates the possibility of missed doses. Though clinical use of pellet implants has declined with the development of oral dosage forms, it nevertheless remains a valuable medical tool in for example, drug absorption studies. Surface area of an implant is readily determined and controlled. Moreover, the effective area of a pellet in contact with body tissues can be measured before and after implantation by simple direct inspection of the implant.

As stated heretofore, devices for subcutaneous introduction of implants are disclosed in the prior art. One such device comprises an injector needle, having a central longitudinal axial bore and a sharp bevelled end, a first plunger having a sharp bevelled end and a second plunger having a blunt end. The first plunger and the second plunger are each removably insertable within the bore of the injector needle. The technique employed with this prior art device is as follows:

The area wherein the pellet is to be inserted is anesthesized with a local anesthetic. A small incision is made in the skin to permit free passage of the injector needle. The first plunger is inserted into the bore of the injector needle, then the injector needle, with the first plunger in place, is inserted into the subcutaneous tissue. When insertion of the injector needle is complete the first plunger is withdrawn from the bore. A drug pellet is then introduced into the injector bore and gently forced down the bore and into the subcutaneous tissues with the blunt end of the second plunger. Once the pellet is fully inserted, the injector with the second plunger seated in the bore is simultaneously withdrawn. The incision is then closed with sutures, a clip, or an adhesive bridge, etc.

The aforementioned prior art device has, however, not proven successful since it suffers from several major defects. First, a preliminary surgical incision is required before the device can be employed. Second, if upon insertion into the subcutaneous tissues the injector needle with first plunger in place is not properly oriented, that is to say, the bevelled sharp end of the first plunger is not in alignment with the bevelled sharp end of the injector needle, insertion of the device will result in considerable tearing of the tissues.

The device of the present invention constitutes an improvement over the above described prior art device. Use of the present device obviates the need for preliminary surgical incision. The instant device makes a clean incision. No stitching or sutures are generally thereafter required. Furthermore, in the device of the present invention, means are provided for preventing improper orientation of the sharp end of the injector needle and the sharp end of the first plunger whereby disadvantageous tearing of the skin and tissues is avoided.

The present invention will now be described in greater detail with reference to the accompanying drawings in which like elements are assigned the same numerical designation.

In the drawings:

FIG. 1 is a plan view, partially in section, of a preferred embodiment of the instant invention;

FIG. 2 is a top plan view showing the complimentary positioned ends respectively of the tubular member and first plunger of FIG. 1;

FIG. 3 is a cross-sectional view taken along the line 33 of FIG. I, and

FIG. 4 is a plan view, partially in section, of the tubular member of FIG. 1 with the second plunger in place, and shown after delivery of a drug pellet.

Referring now to FIG. 1: Injector needle or tubular member 1 has a longitudinal axial bore 2 therethrough, a pointed elongated annular concavely bevelled implanting end 3 and a charging or inlet end portion 4. Bore 2 communicates with end 3 and with inlet end portion 4. A finger hold 5 which can also serve as an insertion limiting stop member is mounted on tubular member 1. A first plunger 6 comprised of solid rod portion 7, head portion 8 and a pointed elongated annular concavely bevelled end 9 is removably insertable in bore 2 of tubular member 1 for slidable movement therein along the longitudinal axis of said tubular member 1 from a first position to a second position. As shown in FIGS. 1 and 2, end 3 of tubular member 1 and end 9 of first plunger 6 are elongated and annular, more particularly they are substantially ellipsoidal. As is more clearly shown in FIGS. 2 and 4 ends 3 and 9 can be aligned to present a complimentary elongated annular concave surface. Means are provided on the first plunger 6 and on the tubular member 1 to ensure that this complimentary alignment of ends 9 and 3 occurs only at one position, viz. the second position referred to above.

As shown in FIG. 1 and 4, end portion 4 of tubular member 1 has a cutout forming a troughlike lip or projection 11 having shoulders 13 and 13' Head portion 8 of first plunger 6 has a complimentary semicylindrical lip or projection 12 having shoulders 14 and 14' As is clear from FIG. 3 lips or projections 11 and 12 will mesh in only one position, that is when shoulders 13 and 13' respectively are aligned opposed to and in contact with shoulders 14 and I4 Moreover, rod portion 7 of first plunger 6 can only be inserted within bore 2 of tubular member 1 to the second position when projections 11 and 12 are positioned so that shoulders 13 and 13' are aligned with respect to shoulders 14 and 14' When so aligned shoulders 14 and 14' can be slidably moved along opposing juxtaposed shoulders 13 and 13' from the first position to the second position at which point only ends 9 and 3 are in alignment as shown in FIGS. 1 and 2.

When at the second position, complimentary aligned ends 9 and 3 present a substantially continuous pointed elongated annular concavely bevelled tip. Providing the device of the present invention with such a tip accounts for certain significant advantages over prior art straight bevelled tips. The device of the instant invention readily penetrates the skin and underlying subcutaneous tissue. No preliminary surgical incision is required. Less pain and tissue damage is occasioned and the need for surgical sutures to close the puncture is generally obviated.

Finger hold is provided on tubular member 1. Hold 5 optionally functions to limit the maximum depth of penetration of end 3 of tubular member 1 to the distance between point of end 3 and shoulder portion 21 of body 15. As shown in FIGS. 1 and 4 body is preferably hour-glass shaped so as to provide a convenient gripping surface for the fingers. One end of hourglass shaped body 15 is unitary with shoulder portion 21. Hold 5 can be fixed in position on or unitary with tubular member 1. Alternatively, it can be adjustable in position along tubular member 1. This optional adjustability feature of hold 5 enables it to be positioned at any one of a plurality of points along the longitudinal axis of tubular member 1 thereby permitting regulation of the maximum depth of penetration of end 3 into the subcutaneous tissues.

Optional adjustability of the position of hold 5 on tubular member 1 can be attained by providing body 15 with releasable friction gripping means for frictionally lockiing body 15 in a selected fixed position on tubular member 1. Alternatively, tubular member 1 can be provided with an external male threaded surface and body 15 with internal complimentary female threads or viceversa whereby the position of hold 5 along the longitudinal axis of tubular member 1 can be suitably adjusted by threading body 15 toward or away from end 3. Alternatively, as shown in FIG. 4 hold 5 has a longitudinal bore therethrough adapted to slidably receive tubular member 1. A second internally threaded bore 23 is provided in body 15 and is adapted to receive therein complimentary threaded set screw 22. Set screw 22 may be threaded into bore 23 to contact tubular member 1 and frictionally fix the position of hold 5 thereon. Set screw 22 can be provided with a slotted head adapted to receive a screwdriver to facilitate tightening of same. Other means for providing optional adjustability of the position of hold 5 on tubular member 1 will readily suggest themselves to the skilled artisan.

FIG. 4 illustrates a further embodiment of the device of the present invention, blunt plunger 16. Plunger 16 is comprised of a solid rod 17 having an enlarged head portion 18 at one end and a blunt tip 19 at the other end. Like rod portion 7 of the first plunger 6, rod 17 is adapted for removable insertion in bore 2 of tubular member 1 for slidable movement therein along the longitudinal axis of tubular member 1. Head portion 18 is larger in diameter than the diameter of bore 2. Thus it serves as a stop which limits the maximum extension of rod 17 within bore 2. As shown in FIG. 4, blunt plunger 16 is preferably of sufficient length so that when fully inserted within bore 2 of tubular member 1 blunt tip 19 of rod 17 extends beyond the tip 10 of end 3 of tubular member 1. This facilitates complete removal of pellet 20 from bore 2.

Understanding of how the components of the device of the present invention cooperate to achieve subcutaneous implant of a drug pellet is best acquired by a consideration of how the device is employed.

Rod portion 7 of the first plunger 6 is inserted within bore 2 of tubular member 1 so that shoulders 13 and 13' of projection 11 of tubular member I are aligned opposed to and in juxtaposition with respect to shoulder l4 and 14' of projection 12 of head portion 8 of the first plunger 6. Rod portion 7 may then be slidably moved in the direction of stop 5 to the second position at which point only end 9 of the first plunger 6 and end 3 of tubular member 1 are complimentarily aligned and form with one another a substantially continuous, pointed, elongated, annular, concavely bevelled surface. Hour-glass shaped body 15 of hold 5 is then grasped between the pointer and index fingers with the thumb resting on head portion 8 of the first plunger 6. Hand pressure is then applied to drive the complimentarily aligned ends of tubular member 1 and first plunger 6 into the subcutaneous tissues. Hold 5 optionally serves to limit the depth of penetration and may optionally be suitably adjusted prior to insertion of the device. When the desired degree of penetration is achieved the device is withdrawn slightly so as to leave in the subcutaneous tissues adjacent the withdrawn tip 10 a pocket adapted to receive a subsequently injected pellet. Thereafter first plunger 6 is completely withdrawn from bore 2 of tubular member 1. A drug pellet 20 is placed on the troughlike lip or projection 11 then driven into and seated within the previously prepared pocket in the subcutaneous tissues by downward slidable movement of blunt plunger 16 in bore 2. Since blunt tip 19 of plunger 16 extends beyond tip 10 of tubular member 1 complete release of pellet 20 from the device is assured. Once the pellet is seated the tubular member 1 and blunt plunger 16 are simultaneously withdrawn. No sutures are generally required to close the puncture.

The device of the present invention can be readily fabricated out of for example stainless steel, carbon steel, hyperchrome steel, chromium, nickeloid, platinum, platinum iridium, gold or silver. Other materials will readily suggest themselves to those skilled in the art.

A further optional modification of the preferred embodiment of the instant invention is the provision of a protective guard for point 10 of end 3 of the tubular member 1. The protective guard may be rigid or plastic material. The guard is preferably a tubular sleeve closed at one end and open at its other end and is adapted to receive through the open end and encase and protect point 10 of end 3.

What is claimed is:

1. An implant device comprising:

a. a tubular member having a central longitudinal axial bore therethrough, a pointed elongated annular concavely bevelled implanting end, and a charging end, each of said ends communicating with said bore;

b. a plunger having a solid, pointed, elongated annular concavely bevelled end, said plunger being removeably inserted in said bore and slideably movable therein along the longitudinal axis of said tubular member from a first position to a second position at which maximum insertion of the plunger into the bore is obtained and the implanting end of the tubular member and the pointed end of the plunger are aligned to form a complimentary substantially continuous pointed elongated annular concavely bevelled penetration surface; and

means for aligning said implanting end and said pointed end, said means for aligning being only one semicircular projection on the charging end of the tubular member, said first projection extending for a distance in the axial direction whereby a pill receiving trough is formed for facilitating introduction of an implant dosage form into the bore of the tubular member, and a second semi-circular projection on the plunger, the first and second projections being complimentary and alignable at only the second position, alignment of the first and second projections serving to simultaneously align said implanting end and said pointed end, said first projection being an extension of the charging end and having a first shoulder and a second shoulder, said plunger having a head portion the diameter of which is larger than the diameter of bore of the tubular member, said second projection being an extension of the head portion of the plunger and having a third shoulder and a fourth shoulder, said plunger being movable within said bore from the first position to the second position only when the first and second shoulders are aligned opposed to and in sliding contact respectively with the third and fourth shoulders. 2. The device as claimed in claim 1 further including an insertion limiting stop member on said tubular member for limiting the maximum depth of penetration of the implanting end of the tubular member.

3. The device as claimed in claim 2 wherein the stop member is fixed in position on the tubular member.

4. The device as claimed in claim 2 wherein the stop member is adjustable in position on the tubular member.

5. The device as claimed in claim 4 wherein said stop member has a longitudinal axial bore adapted to receive said tubular member for slidable movement therein further including gripping means for releasably frictionally fixing the stop member in a selected position on said tubular member.

6. The device as claimed in claim 4 wherein the stop member has a first longitudinal axial bore, the tubular member is disposed within, and slidably movable along the axis of, said first longitudinal axial bore, said stop member having an internally threaded second bore communicating with the first longitudinal axial bore, and a complimentary threaded set screw in said second bore threadable into frictional engagement with the tubular member to fix the position of the stop member on the tubular member.

7. The device as claimed in claim 2 wherein said stop member is substantially hour glass shaped.

8. The device as claimed in claim 2 wherein said stop member 7 also serves as a finger hold.

9. The device as claimed in claim 1 further including means on the tubular member for facilitating gripping of the device.

10. The device as claimed in claim 1, wherein said implanting end and said pointed end are substantially ellipsoidal.

11. The device as claimed in claim I wherein the first projection is a cutout of the charging end of the tubular member and the second projection is a cutout of the head portion of the plunger.

Claims (11)

1. An implant device comprising: a. a tubular member having a central longitudinal axial bore therethrough, a pointed elongated annular concavely bevelled implanting end, and a charging end, each of said ends communicating with said bore; b. a plunger having a solid, pointed, elongated annular concavely bevelled end, said plunger being removeably inserted in said bore and slideably movable therein along the longitudinal axis of said tubular member from a first position to a second position at which maximum insertion of the plunger into the bore is obtained and the implanting end of the tubular member and the pointed end of the plunger are aligned to form a complimentary substantially continuous pointed elongated annular concavely bevelled penetration surface; and c. means for aligning said implanting end and said pointed end, said means for aligning being only one semicircular projection on the charging end of the tubular member, said first projection extending for a distance in the axial direction whereby a pill receiving trough is formed for facilitating introduction of an implant dosage form into the bore of the tubular member, and a second semi-circular projection on the plunger, the first and second projections being complimentary and alignable at only the second position, alignment of the first and second projections serving to simultaneously align said implanting end and said pointed end, said first projection being an extension of the charging end and having a first shoulder and a second shoulder, said plunger having a head portion the diameter of which is larger than the diameter of bore of the tubular member, said second projection being an extension of the head portion of the plunger and having a third shoulder and a fourth shoulder, said plunger being movable within said bore from the first position to the second position only when the first and second shoulders are aligned opposed to and in sliding contact respectively with the third and fourth shoulders.
2. The device as claimed in claim 1 further including an insertion limiting stop member on said tubular member for limiting the maximum depth of penetration of the implanting end of the tubular member.
3. The device as claimed in claim 2 wherein the stop member is fixed in position on the tubular member.
4. The device as claimed in claim 2 wherein the stop member is adjustable in position on the tubular member.
5. The device as claimed in claim 4 wherein said stop member has a longitudinal axial bore adapted to receive said tubular member for slidable movement therein further including gripping means for releasably frictionally fixing the stop member in a selected position on said tubular member.
6. The device as claimed in claim 4 wherein the stop member has a first longitudinal axial bore, the tubular member is disposed within, and slidably movable along the axis of, said first longitudinal axial bore, said stop member having an internally threaded second bore communicating with the first longitudinal axial bore, and a complimentary threaded set screw in said second bore threadable into frictional engagement with the tubular member to fix the position of the stop member on the tubular member.
7. The device as claimed in claim 2 wherein said stop member is substantially hour-glass shaped.
8. The device as claimed in claim 2 wherein said stop member 7 also serves as a finger hold.
9. The device as claimed in claim 1 further including means on the tubular member for facilitating gripping of the device.
10. The device as claimed in claim 1, wherein said implanting end and said pointed end are substantially ellipsoidal.
11. The device as claimed in claim 1 wherein the first projection is a cutout of the charging end of the tubular member and the second projection is a cutout of the head portion of the plunger.
US3921632A 1974-08-16 1974-08-16 Implant device Expired - Lifetime US3921632A (en)

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Cited By (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060083A (en) * 1976-04-01 1977-11-29 Hanson Raymond L Pill gun
US4147164A (en) * 1977-02-14 1979-04-03 Behney Charles A Method of performing implantations in a canine ear or the like for correctional purposes
US4402308A (en) * 1980-11-03 1983-09-06 Scott Walter P Medical implantation device
WO1984000304A1 (en) * 1982-07-08 1984-02-02 Mitchell Harman Injectible sustained release dosage cylinders
US4461280A (en) * 1980-12-15 1984-07-24 Baumgartner George C Surgical instrument and process
US4490139A (en) * 1983-01-28 1984-12-25 Eli Lilly And Company Implant needle and method
US4690682A (en) * 1983-04-15 1987-09-01 Damon Biotech, Inc. Sustained release
EP0292936A2 (en) * 1987-05-26 1988-11-30 Sumitomo Pharmaceuticals Company, Limited Device for administering solid preparations
US4789516A (en) * 1983-04-15 1988-12-06 Damon Biotech, Inc Production of sustained released system
EP0304700A1 (en) * 1987-08-11 1989-03-01 Hoechst Aktiengesellschaft Apparatus for placing implants
US4820267A (en) * 1985-02-19 1989-04-11 Endocon, Inc. Cartridge injector for pellet medicaments
US5112614A (en) * 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5152747A (en) * 1989-08-16 1992-10-06 Olivier Lucien C Implantable reservoir and balloon catheter system
US5266325A (en) * 1990-09-28 1993-11-30 Hydro Med Science Division Of National Patent Development Corp. Preparation of homogeneous hydrogel copolymers
US5292515A (en) * 1990-09-28 1994-03-08 Hydro Med Sciences, A Division Of National Patent Development Corporation Manufacture of water-swellable hydrophilic articles and drug delivery devices
US5447499A (en) * 1992-12-23 1995-09-05 New Dimensions In Medicine, Inc. Wound dressing having a cylindrical shape for deep wounds
US5891155A (en) * 1995-01-27 1999-04-06 Scimed Life Systems, Inc. Embolizing system
US6264626B1 (en) * 1999-06-25 2001-07-24 Mcneil-Ppc, Inc. Paperboard applicators having improved gripping features
US6270472B1 (en) 1998-12-29 2001-08-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Apparatus and a method for automatically introducing implants into soft tissue with adjustable spacing
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6368442B1 (en) 1999-06-25 2002-04-09 Mcneil-Ppc, Inc. Method of making applicators having improved finger grip features
EP1216721A2 (en) * 2000-12-22 2002-06-26 Frank M. Bardani Implant device and dosage form employable therein
US20020151979A1 (en) * 1999-08-18 2002-10-17 Lambrecht Greg H. Devices and method for nucleus pulposus augmentation and retention
US6488649B1 (en) 1998-11-24 2002-12-03 Edward M. Lichten Implant device
US20030009227A1 (en) * 1999-08-18 2003-01-09 Lambrecht Gregory H. Methods of reinforcing an annulus fibrosis
US20030176854A1 (en) * 2002-03-11 2003-09-18 Alcon, Inc. Implantable drug delivery system
US20030233101A1 (en) * 2002-06-17 2003-12-18 Senorx, Inc. Plugged tip delivery tube for marker placement
US20040024465A1 (en) * 1999-08-18 2004-02-05 Gregory Lambrecht Devices and method for augmenting a vertebral disc
US6699493B2 (en) 2000-11-29 2004-03-02 Oculex Pharmaceuticals, Inc. Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
US20040044412A1 (en) * 1999-08-18 2004-03-04 Gregory Lambrecht Devices and method for augmenting a vertebral disc
US6752753B1 (en) 1999-10-15 2004-06-22 Deschutes Medical Products, Inc. Brachytherapy instrument and methods
US20040133229A1 (en) * 2000-08-18 2004-07-08 Lambrecht Gregory H. Minimally invasive system for manipulating intervertebral disc tissue
US20040267277A1 (en) * 2003-06-30 2004-12-30 Zannis Anthony D. Implant delivery instrument
US20050004578A1 (en) * 1999-08-18 2005-01-06 Lambrecht Gregory H. Apparatus delivery in an intervertebral disc
US20060067966A1 (en) * 1995-06-02 2006-03-30 Allergan, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US20060068012A1 (en) * 2004-09-29 2006-03-30 Bausch & Lomb Incorporated Process for preparing poly (vinyl alcohol) drug delivery devices with humidity control
US20060067978A1 (en) * 2004-09-29 2006-03-30 Bausch & Lomb Incorporated Process for preparing poly(vinyl alcohol) drug delivery devices
US20060173280A1 (en) * 2003-11-17 2006-08-03 Inrad, Inc. Multi Mode Imaging Marker
US20060241411A1 (en) * 2005-04-20 2006-10-26 Inrad, Inc. Marking device with retracable cannula
US7201775B2 (en) 2002-09-24 2007-04-10 Bogomir Gorensek Stabilizing device for intervertebral disc, and methods thereof
US20070298074A1 (en) * 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20080077157A1 (en) * 2006-07-26 2008-03-27 Medical Instrument Development Laboratories, Inc. Insertion apparatus having a concave surface
US20080167598A1 (en) * 2007-01-10 2008-07-10 The Procter & Gamble Company Active applicator
US20080226741A1 (en) * 2006-11-03 2008-09-18 Boston Scientific Scimed, Inc. Cross-linked Polymer Particles
US20080311170A1 (en) * 2007-04-27 2008-12-18 Indevus Pharmaceuticals, Inc. Implant device release agents and methods of using same
US7500978B2 (en) 2003-06-20 2009-03-10 Intrinsic Therapeutics, Inc. Method for delivering and positioning implants in the intervertebral disc environment
US7553329B2 (en) 1999-08-18 2009-06-30 Intrinsic Therapeutics, Inc. Stabilized intervertebral disc barrier
US20090171198A1 (en) * 2006-08-04 2009-07-02 Jones Michael L Powdered marker
US20100010341A1 (en) * 2006-12-18 2010-01-14 Talpade Dnyanesh A Biopsy Marker with In Situ-Generated Imaging Properties
US20100021522A1 (en) * 2008-06-25 2010-01-28 Endo Pharmaceuticals Solutions Inc. Sustained delivery of exenatide and other peptides
US20100030072A1 (en) * 2006-12-12 2010-02-04 Casanova R Michael Multiple Imaging Mode Tissue Marker
US20100082102A1 (en) * 2008-09-23 2010-04-01 Senorx, Inc. Porous bioabsorbable implant
US7727241B2 (en) 2003-06-20 2010-06-01 Intrinsic Therapeutics, Inc. Device for delivering an implant through an annular defect in an intervertebral disc
US20100198059A1 (en) * 1999-02-02 2010-08-05 Senorx, Inc. Remotely activated marker
US20100204570A1 (en) * 2009-02-06 2010-08-12 Paul Lubock Anchor markers
US20100247594A1 (en) * 2005-03-11 2010-09-30 Endo Pharmaceuticals Solutions Inc. Delivery of dry formulations of octreotide
US20100298696A1 (en) * 2003-11-17 2010-11-25 Bard Peripheral Vascular, Inc. Self-contained, self-piercing, side-expelling marking apparatus
US20100298698A1 (en) * 2000-11-20 2010-11-25 Senorx, Inc. Tissue site markers for in vivo imaging
US20100317579A1 (en) * 2005-03-11 2010-12-16 Endo Pharmaceuticals Solutions Inc. Controlled release formulations of octreotide
US20100324416A1 (en) * 1999-02-02 2010-12-23 Senorx, Inc. Cavity-filling biopsy site markers
US20100331668A1 (en) * 2008-01-31 2010-12-30 Ranpura Himanshu M Biopsy Tissue Marker
US20110028836A1 (en) * 2008-12-30 2011-02-03 Himanshu Ranpura Marker delivery device for tissue marker placement
US20110054612A1 (en) * 2009-08-27 2011-03-03 Houdin Dehnad Bone implants for the treatment of infection
US20110082547A1 (en) * 1997-10-10 2011-04-07 Senorx, Inc. Tissue marking implant
US20110092815A1 (en) * 2003-05-23 2011-04-21 Senorx, Inc. Marker or filler forming fluid
US7959679B2 (en) 1999-08-18 2011-06-14 Intrinsic Therapeutics, Inc. Intervertebral anulus and nucleus augmentation
US7960335B2 (en) 2008-06-25 2011-06-14 Endo Pharmaceuticals Solutions Inc. Octreotide implant having a release agent and uses thereof
US7972337B2 (en) 2005-12-28 2011-07-05 Intrinsic Therapeutics, Inc. Devices and methods for bone anchoring
US20110166448A1 (en) * 1999-02-02 2011-07-07 Jones Michael L Marker delivery device with releasable plug
US20110184449A1 (en) * 2006-08-04 2011-07-28 Senorx, Inc. Marker delivery device with obturator
US20110184280A1 (en) * 1999-02-02 2011-07-28 Jones Michael L Intracorporeal marker and marker delivery device
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8034366B2 (en) 2003-01-09 2011-10-11 Allergan, Inc. Ocular implant made by a double extrusion process
US8062652B2 (en) 2004-06-17 2011-11-22 Endo Pharmaceuticals Solutions Inc. Compositions and methods for treating precocious puberty
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8224424B2 (en) 1999-02-02 2012-07-17 Senorx, Inc. Tissue site markers for in vivo imaging
US8231678B2 (en) 1999-08-18 2012-07-31 Intrinsic Therapeutics, Inc. Method of treating a herniated disc
US8242099B2 (en) 2000-07-05 2012-08-14 Allergan, Inc. Implants and methods for treating inflammation-mediated conditions of the eye
US8323341B2 (en) 2007-09-07 2012-12-04 Intrinsic Therapeutics, Inc. Impaction grafting for vertebral fusion
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US8437834B2 (en) 2006-10-23 2013-05-07 C. R. Bard, Inc. Breast marker
US8454612B2 (en) 2007-09-07 2013-06-04 Intrinsic Therapeutics, Inc. Method for vertebral endplate reconstruction
US8486028B2 (en) 2005-10-07 2013-07-16 Bard Peripheral Vascular, Inc. Tissue marking apparatus having drug-eluting tissue marker
US8579931B2 (en) 1999-06-17 2013-11-12 Bard Peripheral Vascular, Inc. Apparatus for the percutaneous marking of a lesion
US8626269B2 (en) 2003-05-23 2014-01-07 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US8771323B2 (en) 2010-11-12 2014-07-08 Silver Bullet Therapeutics, Inc. Bone implant and systems that controllably releases silver
US8802129B2 (en) 2004-04-30 2014-08-12 Allergan, Inc. Methods for treating retinopathy with extended therapeutic effect
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
US8927004B1 (en) 2014-06-11 2015-01-06 Silver Bullet Therapeutics, Inc. Bioabsorbable substrates and systems that controllably release antimicrobial metal ions
US9114197B1 (en) 2014-06-11 2015-08-25 Silver Bullett Therapeutics, Inc. Coatings for the controllable release of antimicrobial metal ions
US9149341B2 (en) 1999-02-02 2015-10-06 Senorx, Inc Deployment of polysaccharide markers for treating a site within a patient
US9452242B2 (en) 2014-06-11 2016-09-27 Silver Bullet Therapeutics, Inc. Enhancement of antimicrobial silver, silver coatings, or silver platings
US20170065805A1 (en) * 2015-09-04 2017-03-09 The Sotopelle Group, Llc Therapeutic trocar/inserter and method of use
US9700304B2 (en) 2010-04-19 2017-07-11 Gold Thread Llc Filament implant system and method
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US9821094B2 (en) 2014-06-11 2017-11-21 Silver Bullet Therapeutics, Inc. Coatings for the controllable release of antimicrobial metal ions
US9849027B2 (en) 2007-11-08 2017-12-26 Alimera Sciences, Inc. Ocular implantation device

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2513014A (en) * 1946-11-18 1950-06-27 Abbott Lab Apparatus for implanting medicinal pellets subcutaneously
US2751907A (en) * 1953-09-18 1956-06-26 Bishop & Co Platinum Works J Pellet injector
US2907327A (en) * 1957-02-08 1959-10-06 Pfizer & Co C Pellet implanter
US2952256A (en) * 1957-12-06 1960-09-13 Sierra Eng Co Epidural needle
US2959170A (en) * 1957-12-26 1960-11-08 Ernest S V Laub Hypodermic syringe
US3097647A (en) * 1958-09-12 1963-07-16 Brunswick Corp Surgical apparatus
US3297031A (en) * 1966-02-07 1967-01-10 Henry F Bray Suppository applicator
US3585986A (en) * 1969-08-21 1971-06-22 Becton Dickinson Co Stylet
US3630192A (en) * 1969-07-14 1971-12-28 Khosrow Jamshidi Instrument for internal organ biopsy
US3788320A (en) * 1972-02-25 1974-01-29 Kendall & Co Spinal needle

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2513014A (en) * 1946-11-18 1950-06-27 Abbott Lab Apparatus for implanting medicinal pellets subcutaneously
US2751907A (en) * 1953-09-18 1956-06-26 Bishop & Co Platinum Works J Pellet injector
US2907327A (en) * 1957-02-08 1959-10-06 Pfizer & Co C Pellet implanter
US2952256A (en) * 1957-12-06 1960-09-13 Sierra Eng Co Epidural needle
US2959170A (en) * 1957-12-26 1960-11-08 Ernest S V Laub Hypodermic syringe
US3097647A (en) * 1958-09-12 1963-07-16 Brunswick Corp Surgical apparatus
US3297031A (en) * 1966-02-07 1967-01-10 Henry F Bray Suppository applicator
US3630192A (en) * 1969-07-14 1971-12-28 Khosrow Jamshidi Instrument for internal organ biopsy
US3585986A (en) * 1969-08-21 1971-06-22 Becton Dickinson Co Stylet
US3788320A (en) * 1972-02-25 1974-01-29 Kendall & Co Spinal needle

Cited By (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060083A (en) * 1976-04-01 1977-11-29 Hanson Raymond L Pill gun
US4147164A (en) * 1977-02-14 1979-04-03 Behney Charles A Method of performing implantations in a canine ear or the like for correctional purposes
US4402308A (en) * 1980-11-03 1983-09-06 Scott Walter P Medical implantation device
US4461280A (en) * 1980-12-15 1984-07-24 Baumgartner George C Surgical instrument and process
WO1984000304A1 (en) * 1982-07-08 1984-02-02 Mitchell Harman Injectible sustained release dosage cylinders
US4490139A (en) * 1983-01-28 1984-12-25 Eli Lilly And Company Implant needle and method
US4690682A (en) * 1983-04-15 1987-09-01 Damon Biotech, Inc. Sustained release
US4789516A (en) * 1983-04-15 1988-12-06 Damon Biotech, Inc Production of sustained released system
US4820267A (en) * 1985-02-19 1989-04-11 Endocon, Inc. Cartridge injector for pellet medicaments
EP0292936A3 (en) * 1987-05-26 1991-04-03 Nissho Corporation Device for administering solid preparations
EP0292936A2 (en) * 1987-05-26 1988-11-30 Sumitomo Pharmaceuticals Company, Limited Device for administering solid preparations
US4941874A (en) * 1987-08-11 1990-07-17 Hoechst Aktiengesellschaft Device for the administration of implants
EP0304700A1 (en) * 1987-08-11 1989-03-01 Hoechst Aktiengesellschaft Apparatus for placing implants
US5152747A (en) * 1989-08-16 1992-10-06 Olivier Lucien C Implantable reservoir and balloon catheter system
US5112614A (en) * 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5660847A (en) * 1989-09-14 1997-08-26 Alza Corporation Implantable delivery dispenser comprising exit port
US5266325A (en) * 1990-09-28 1993-11-30 Hydro Med Science Division Of National Patent Development Corp. Preparation of homogeneous hydrogel copolymers
US5292515A (en) * 1990-09-28 1994-03-08 Hydro Med Sciences, A Division Of National Patent Development Corporation Manufacture of water-swellable hydrophilic articles and drug delivery devices
US5447499A (en) * 1992-12-23 1995-09-05 New Dimensions In Medicine, Inc. Wound dressing having a cylindrical shape for deep wounds
US5895411A (en) * 1995-01-27 1999-04-20 Scimed Life Systems Inc. Embolizing system
US5891155A (en) * 1995-01-27 1999-04-06 Scimed Life Systems, Inc. Embolizing system
US20060067966A1 (en) * 1995-06-02 2006-03-30 Allergan, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US8157862B2 (en) 1997-10-10 2012-04-17 Senorx, Inc. Tissue marking implant
US10058416B2 (en) 1997-10-10 2018-08-28 Senorx, Inc. Tissue marking implant
US20110082547A1 (en) * 1997-10-10 2011-04-07 Senorx, Inc. Tissue marking implant
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US9480554B2 (en) 1997-10-10 2016-11-01 Senorx, Inc. Tissue marking implant
US9039763B2 (en) 1997-10-10 2015-05-26 Senorx, Inc. Tissue marking implant
US6488649B1 (en) 1998-11-24 2002-12-03 Edward M. Lichten Implant device
US6270472B1 (en) 1998-12-29 2001-08-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Apparatus and a method for automatically introducing implants into soft tissue with adjustable spacing
US9649093B2 (en) 1999-02-02 2017-05-16 Senorx, Inc. Cavity-filling biopsy site markers
US20110166448A1 (en) * 1999-02-02 2011-07-07 Jones Michael L Marker delivery device with releasable plug
US8219182B2 (en) 1999-02-02 2012-07-10 Senorx, Inc. Cavity-filling biopsy site markers
US8224424B2 (en) 1999-02-02 2012-07-17 Senorx, Inc. Tissue site markers for in vivo imaging
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US8498693B2 (en) 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
US8626270B2 (en) 1999-02-02 2014-01-07 Senorx, Inc. Cavity-filling biopsy site markers
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US9861294B2 (en) 1999-02-02 2018-01-09 Senorx, Inc. Marker delivery device with releasable plug
US20100324416A1 (en) * 1999-02-02 2010-12-23 Senorx, Inc. Cavity-filling biopsy site markers
US8965486B2 (en) 1999-02-02 2015-02-24 Senorx, Inc. Cavity filling biopsy site markers
US20100198059A1 (en) * 1999-02-02 2010-08-05 Senorx, Inc. Remotely activated marker
US9149341B2 (en) 1999-02-02 2015-10-06 Senorx, Inc Deployment of polysaccharide markers for treating a site within a patient
US9044162B2 (en) 1999-02-02 2015-06-02 Senorx, Inc. Marker delivery device with releasable plug
US9237937B2 (en) 1999-02-02 2016-01-19 Senorx, Inc. Cavity-filling biopsy site markers
US20110184280A1 (en) * 1999-02-02 2011-07-28 Jones Michael L Intracorporeal marker and marker delivery device
US9579159B2 (en) 1999-06-17 2017-02-28 Bard Peripheral Vascular, Inc. Apparatus for the percutaneous marking of a lesion
US8579931B2 (en) 1999-06-17 2013-11-12 Bard Peripheral Vascular, Inc. Apparatus for the percutaneous marking of a lesion
US6685788B2 (en) 1999-06-25 2004-02-03 Mcneil-Ppc, Inc. Method of making applicators having improved finger grip features
US6264626B1 (en) * 1999-06-25 2001-07-24 Mcneil-Ppc, Inc. Paperboard applicators having improved gripping features
US6368442B1 (en) 1999-06-25 2002-04-09 Mcneil-Ppc, Inc. Method of making applicators having improved finger grip features
US6685787B2 (en) 1999-06-25 2004-02-03 Mcneil-Ppc, Inc. Method of making applicators having improved finger grip features
US8021425B2 (en) 1999-08-18 2011-09-20 Intrinsic Therapeutics, Inc. Versatile method of repairing an intervertebral disc
US8409284B2 (en) 1999-08-18 2013-04-02 Intrinsic Therapeutics, Inc. Methods of repairing herniated segments in the disc
US7124761B2 (en) 1999-08-18 2006-10-24 Intrinsic Therapeutics, Inc. Deployment devices and methods for vertebral disc augmentation
US7094258B2 (en) 1999-08-18 2006-08-22 Intrinsic Therapeutics, Inc. Methods of reinforcing an annulus fibrosis
US8257437B2 (en) 1999-08-18 2012-09-04 Intrinsic Therapeutics, Inc. Methods of intervertebral disc augmentation
US8231678B2 (en) 1999-08-18 2012-07-31 Intrinsic Therapeutics, Inc. Method of treating a herniated disc
US7220281B2 (en) 1999-08-18 2007-05-22 Intrinsic Therapeutics, Inc. Implant for reinforcing and annulus fibrosis
US7258700B2 (en) 1999-08-18 2007-08-21 Intrinsic Therapeutics, Inc. Devices and method for nucleus pulposus augmentation and retention
US20040024465A1 (en) * 1999-08-18 2004-02-05 Gregory Lambrecht Devices and method for augmenting a vertebral disc
US20040034429A1 (en) * 1999-08-18 2004-02-19 Lambrecht Gregg H, Anchored anulus method
US7563282B2 (en) 1999-08-18 2009-07-21 Intrinsic Therapeutics, Inc. Method of supporting nucleus pulposus
US8025698B2 (en) 1999-08-18 2011-09-27 Intrinsic Therapeutics, Inc. Method of rehabilitating an anulus fibrosus
US20040044412A1 (en) * 1999-08-18 2004-03-04 Gregory Lambrecht Devices and method for augmenting a vertebral disc
US8002836B2 (en) 1999-08-18 2011-08-23 Intrinsic Therapeutics, Inc. Method for the treatment of the intervertebral disc anulus
US7507243B2 (en) * 1999-08-18 2009-03-24 Gregory Lambrecht Devices and method for augmenting a vertebral disc
US7513911B2 (en) 1999-08-18 2009-04-07 Intrinsic Therapeutics, Inc. Method of implanting dynamically stable spinal implant
US7524333B2 (en) 1999-08-18 2009-04-28 Intrinsic Therapeutics, Inc. Method of anchoring an implant in an intervertebral disc
US7553330B2 (en) 1999-08-18 2009-06-30 Intrinsic Therapeutics, Inc. Methods of reinforcing an intervertebral disc annulus
US7553329B2 (en) 1999-08-18 2009-06-30 Intrinsic Therapeutics, Inc. Stabilized intervertebral disc barrier
US7998213B2 (en) 1999-08-18 2011-08-16 Intrinsic Therapeutics, Inc. Intervertebral disc herniation repair
US20030009227A1 (en) * 1999-08-18 2003-01-09 Lambrecht Gregory H. Methods of reinforcing an annulus fibrosis
US7717961B2 (en) 1999-08-18 2010-05-18 Intrinsic Therapeutics, Inc. Apparatus delivery in an intervertebral disc
US9706947B2 (en) 1999-08-18 2017-07-18 Intrinsic Therapeutics, Inc. Method of performing an anchor implantation procedure within a disc
US7959679B2 (en) 1999-08-18 2011-06-14 Intrinsic Therapeutics, Inc. Intervertebral anulus and nucleus augmentation
US20040097924A1 (en) * 1999-08-18 2004-05-20 Gregory Lambrecht Devices and method for augmenting a vertebral disc
US7879097B2 (en) 1999-08-18 2011-02-01 Intrinsic Therapeutics, Inc. Method of performing a procedure within a disc
US7867278B2 (en) 1999-08-18 2011-01-11 Intrinsic Therapeutics, Inc. Intervertebral disc anulus implant
US9333087B2 (en) 1999-08-18 2016-05-10 Intrinsic Therapeutics, Inc. Herniated disc repair
US7658765B2 (en) 1999-08-18 2010-02-09 Intrinsic Therapeutics, Inc. Resilient intervertebral disc implant
US7749275B2 (en) 1999-08-18 2010-07-06 Intrinsic Therapeutics, Inc. Method of reducing spinal implant migration
US20050004578A1 (en) * 1999-08-18 2005-01-06 Lambrecht Gregory H. Apparatus delivery in an intervertebral disc
US20020151979A1 (en) * 1999-08-18 2002-10-17 Lambrecht Greg H. Devices and method for nucleus pulposus augmentation and retention
US6752753B1 (en) 1999-10-15 2004-06-22 Deschutes Medical Products, Inc. Brachytherapy instrument and methods
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US8242099B2 (en) 2000-07-05 2012-08-14 Allergan, Inc. Implants and methods for treating inflammation-mediated conditions of the eye
US9012437B2 (en) 2000-07-05 2015-04-21 Allergan, Inc. Implants and methods for treating inflammation-mediated conditions of the eye
US9775849B2 (en) 2000-07-05 2017-10-03 Allergan, Inc. Implants and methods for treating inflammation-mediated conditions of the eye
US20040133229A1 (en) * 2000-08-18 2004-07-08 Lambrecht Gregory H. Minimally invasive system for manipulating intervertebral disc tissue
US20040138673A1 (en) * 2000-08-18 2004-07-15 Lambrecht Gregory H. Lateral probe advancement in intervertebral disc tissue
US7144397B2 (en) 2000-08-18 2006-12-05 Intrinsic Therapeutics, Inc. Minimally invasive system for manipulating intervertebral disc tissue
US8718745B2 (en) 2000-11-20 2014-05-06 Senorx, Inc. Tissue site markers for in vivo imaging
US20100298698A1 (en) * 2000-11-20 2010-11-25 Senorx, Inc. Tissue site markers for in vivo imaging
US9283178B2 (en) 2000-11-29 2016-03-15 Allergan, Inc. Methods for treating edema in the eye and intraocular implants for use therefor
US7767223B2 (en) 2000-11-29 2010-08-03 Allergan, Inc. Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use
US7033605B2 (en) 2000-11-29 2006-04-25 Allergan, Inc. Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
US7846468B2 (en) 2000-11-29 2010-12-07 Allergan, Inc. Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
US20060198871A1 (en) * 2000-11-29 2006-09-07 Allergan, Inc. Methods for treating neovascularization and intravitreal implants
US7625582B2 (en) 2000-11-29 2009-12-01 Allergan, Inc. Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
US8071120B2 (en) 2000-11-29 2011-12-06 Allergan, Inc. Methods for treating neovascularization and intravitreal implants
US9592242B2 (en) 2000-11-29 2017-03-14 Allergan, Inc. Methods for treating edema in the eye and intraocular implants for use therefor
US8828446B2 (en) 2000-11-29 2014-09-09 Allergan, Inc. Method for reducing transplant rejection in the eye and intraocular implants for use therefor
US20050249710A1 (en) * 2000-11-29 2005-11-10 Allergan, Inc. Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use
US8043628B2 (en) 2000-11-29 2011-10-25 Allergan, Inc. Methods for reducing edema
US6699493B2 (en) 2000-11-29 2004-03-02 Oculex Pharmaceuticals, Inc. Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
US8088407B2 (en) 2000-11-29 2012-01-03 Allergan, Inc. Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
US20040137034A1 (en) * 2000-11-29 2004-07-15 Wong Vernon G. Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
EP1216721A3 (en) * 2000-12-22 2002-08-07 Frank M. Bardani Implant device and dosage form employable therein
US6478790B2 (en) * 2000-12-22 2002-11-12 Frank M. Bardani Implant device and dosage form employable therein
EP1216721A2 (en) * 2000-12-22 2002-06-26 Frank M. Bardani Implant device and dosage form employable therein
US20100022945A1 (en) * 2002-03-11 2010-01-28 Theron Robert Rodstrom Implantable drug delivery system
US20030176854A1 (en) * 2002-03-11 2003-09-18 Alcon, Inc. Implantable drug delivery system
US7621907B2 (en) 2002-03-11 2009-11-24 Alcon, Inc. Implantable drug delivery system
US8177792B2 (en) 2002-06-17 2012-05-15 Senorx, Inc. Plugged tip delivery tube for marker placement
US8784433B2 (en) 2002-06-17 2014-07-22 Senorx, Inc. Plugged tip delivery tube for marker placement
US20030233101A1 (en) * 2002-06-17 2003-12-18 Senorx, Inc. Plugged tip delivery tube for marker placement
US7651505B2 (en) * 2002-06-17 2010-01-26 Senorx, Inc. Plugged tip delivery for marker placement
US7201775B2 (en) 2002-09-24 2007-04-10 Bogomir Gorensek Stabilizing device for intervertebral disc, and methods thereof
US9848956B2 (en) 2002-11-18 2017-12-26 Bard Peripheral Vascular, Inc. Self-contained, self-piercing, side-expelling marking apparatus
US8034370B2 (en) 2003-01-09 2011-10-11 Allergan, Inc. Ocular implant made by a double extrusion process
US8034366B2 (en) 2003-01-09 2011-10-11 Allergan, Inc. Ocular implant made by a double extrusion process
US10076526B2 (en) 2003-01-09 2018-09-18 Allergan, Inc. Ocular implant made by a double extrusion process
US9192511B2 (en) 2003-01-09 2015-11-24 Allergan, Inc. Ocular implant made by a double extrusion process
US8778381B2 (en) 2003-01-09 2014-07-15 Allergan, Inc. Ocular implant made by a double extrusion process
US8506987B2 (en) 2003-01-09 2013-08-13 Allergan, Inc. Ocular implant made by a double extrusion process
US8318070B2 (en) 2003-01-09 2012-11-27 Allergan, Inc. Ocular implant made by a double extrusion process
US8626269B2 (en) 2003-05-23 2014-01-07 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US9801688B2 (en) 2003-05-23 2017-10-31 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US8639315B2 (en) 2003-05-23 2014-01-28 Senorx, Inc. Marker or filler forming fluid
US8447386B2 (en) 2003-05-23 2013-05-21 Senorx, Inc. Marker or filler forming fluid
US8880154B2 (en) 2003-05-23 2014-11-04 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US10045832B2 (en) 2003-05-23 2018-08-14 Senorx, Inc. Marker or filler forming fluid
US20110092815A1 (en) * 2003-05-23 2011-04-21 Senorx, Inc. Marker or filler forming fluid
US7500978B2 (en) 2003-06-20 2009-03-10 Intrinsic Therapeutics, Inc. Method for delivering and positioning implants in the intervertebral disc environment
US7727241B2 (en) 2003-06-20 2010-06-01 Intrinsic Therapeutics, Inc. Device for delivering an implant through an annular defect in an intervertebral disc
US7819880B2 (en) * 2003-06-30 2010-10-26 Depuy Products, Inc. Implant delivery instrument
US20040267277A1 (en) * 2003-06-30 2004-12-30 Zannis Anthony D. Implant delivery instrument
US20060173280A1 (en) * 2003-11-17 2006-08-03 Inrad, Inc. Multi Mode Imaging Marker
US8634899B2 (en) 2003-11-17 2014-01-21 Bard Peripheral Vascular, Inc. Multi mode imaging marker
US20100298696A1 (en) * 2003-11-17 2010-11-25 Bard Peripheral Vascular, Inc. Self-contained, self-piercing, side-expelling marking apparatus
US9233071B2 (en) 2004-04-30 2016-01-12 Allergan, Inc. Methods for treating retinopathy with extended therapeutic effect
US8911768B2 (en) 2004-04-30 2014-12-16 Allergan, Inc. Methods for treating retinopathy with extended therapeutic effect
US8802129B2 (en) 2004-04-30 2014-08-12 Allergan, Inc. Methods for treating retinopathy with extended therapeutic effect
US8062652B2 (en) 2004-06-17 2011-11-22 Endo Pharmaceuticals Solutions Inc. Compositions and methods for treating precocious puberty
US20060067978A1 (en) * 2004-09-29 2006-03-30 Bausch & Lomb Incorporated Process for preparing poly(vinyl alcohol) drug delivery devices
US20060068012A1 (en) * 2004-09-29 2006-03-30 Bausch & Lomb Incorporated Process for preparing poly (vinyl alcohol) drug delivery devices with humidity control
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US20100317579A1 (en) * 2005-03-11 2010-12-16 Endo Pharmaceuticals Solutions Inc. Controlled release formulations of octreotide
US20110009338A1 (en) * 2005-03-11 2011-01-13 Endo Pharmaceuticals Solutions Inc. Controlled release formulations of octreotide
US8507432B2 (en) 2005-03-11 2013-08-13 Endo Pharmaceuticals Solutions Inc. Controlled release formulations of octreotide
US20100247594A1 (en) * 2005-03-11 2010-09-30 Endo Pharmaceuticals Solutions Inc. Delivery of dry formulations of octreotide
US20060241411A1 (en) * 2005-04-20 2006-10-26 Inrad, Inc. Marking device with retracable cannula
US8486028B2 (en) 2005-10-07 2013-07-16 Bard Peripheral Vascular, Inc. Tissue marking apparatus having drug-eluting tissue marker
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US9610106B2 (en) 2005-12-28 2017-04-04 Intrinsic Therapeutics, Inc. Bone anchor systems
US7972337B2 (en) 2005-12-28 2011-07-05 Intrinsic Therapeutics, Inc. Devices and methods for bone anchoring
US8394146B2 (en) 2005-12-28 2013-03-12 Intrinsic Therapeutics, Inc. Vertebral anchoring methods
US8114082B2 (en) 2005-12-28 2012-02-14 Intrinsic Therapeutics, Inc. Anchoring system for disc repair
US9039741B2 (en) 2005-12-28 2015-05-26 Intrinsic Therapeutics, Inc. Bone anchor systems
US20070298074A1 (en) * 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20080077157A1 (en) * 2006-07-26 2008-03-27 Medical Instrument Development Laboratories, Inc. Insertion apparatus having a concave surface
US20090171198A1 (en) * 2006-08-04 2009-07-02 Jones Michael L Powdered marker
US20110184449A1 (en) * 2006-08-04 2011-07-28 Senorx, Inc. Marker delivery device with obturator
US8437834B2 (en) 2006-10-23 2013-05-07 C. R. Bard, Inc. Breast marker
US20080226741A1 (en) * 2006-11-03 2008-09-18 Boston Scientific Scimed, Inc. Cross-linked Polymer Particles
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US9579077B2 (en) 2006-12-12 2017-02-28 C.R. Bard, Inc. Multiple imaging mode tissue marker
US20100030072A1 (en) * 2006-12-12 2010-02-04 Casanova R Michael Multiple Imaging Mode Tissue Marker
US9901415B2 (en) 2006-12-12 2018-02-27 C. R. Bard, Inc. Multiple imaging mode tissue marker
US9042965B2 (en) 2006-12-18 2015-05-26 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
US20100010341A1 (en) * 2006-12-18 2010-01-14 Talpade Dnyanesh A Biopsy Marker with In Situ-Generated Imaging Properties
US8401622B2 (en) 2006-12-18 2013-03-19 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
US20080167598A1 (en) * 2007-01-10 2008-07-10 The Procter & Gamble Company Active applicator
US20080311170A1 (en) * 2007-04-27 2008-12-18 Indevus Pharmaceuticals, Inc. Implant device release agents and methods of using same
US9120249B2 (en) 2007-04-27 2015-09-01 Endo Pharmaceuticals Solutions Inc. Implant device release agents and methods of using same
US8361155B2 (en) 2007-09-07 2013-01-29 Intrinsic Therapeutics, Inc. Soft tissue impaction methods
US10076424B2 (en) 2007-09-07 2018-09-18 Intrinsic Therapeutics, Inc. Impaction systems
US8323341B2 (en) 2007-09-07 2012-12-04 Intrinsic Therapeutics, Inc. Impaction grafting for vertebral fusion
US8454612B2 (en) 2007-09-07 2013-06-04 Intrinsic Therapeutics, Inc. Method for vertebral endplate reconstruction
US9226832B2 (en) 2007-09-07 2016-01-05 Intrinsic Therapeutics, Inc. Interbody fusion material retention methods
US9849027B2 (en) 2007-11-08 2017-12-26 Alimera Sciences, Inc. Ocular implantation device
US8311610B2 (en) 2008-01-31 2012-11-13 C. R. Bard, Inc. Biopsy tissue marker
US20100331668A1 (en) * 2008-01-31 2010-12-30 Ranpura Himanshu M Biopsy Tissue Marker
US8475820B2 (en) 2008-06-25 2013-07-02 Endo Pharmaceuticals Solutions Inc. Method of manufacturing an implantable device
US20100292144A1 (en) * 2008-06-25 2010-11-18 Endo Pharmaceuticals Solutions Inc. Sustained delivery of exenatide and other peptides
US9072786B2 (en) 2008-06-25 2015-07-07 Endo Pharmaceuticals Solutions Inc. Method of manufacturing an implantable device
US8071537B2 (en) 2008-06-25 2011-12-06 Endo Pharmaceuticals Solutions Inc. Implantable device for the sustained release of a polypeptide
US20110206745A1 (en) * 2008-06-25 2011-08-25 Endo Pharmaceuticals Solutions Inc. Octreotide implant having a release agent
US8383577B2 (en) 2008-06-25 2013-02-26 Endo Pharmaceuticals Solutions, Inc. Octreotide implant having a release agent
US20100021522A1 (en) * 2008-06-25 2010-01-28 Endo Pharmaceuticals Solutions Inc. Sustained delivery of exenatide and other peptides
US7960335B2 (en) 2008-06-25 2011-06-14 Endo Pharmaceuticals Solutions Inc. Octreotide implant having a release agent and uses thereof
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
US20100082102A1 (en) * 2008-09-23 2010-04-01 Senorx, Inc. Porous bioabsorbable implant
US8670818B2 (en) 2008-12-30 2014-03-11 C. R. Bard, Inc. Marker delivery device for tissue marker placement
US20110028836A1 (en) * 2008-12-30 2011-02-03 Himanshu Ranpura Marker delivery device for tissue marker placement
US20100204570A1 (en) * 2009-02-06 2010-08-12 Paul Lubock Anchor markers
US20110054612A1 (en) * 2009-08-27 2011-03-03 Houdin Dehnad Bone implants for the treatment of infection
US10004548B2 (en) 2009-08-27 2018-06-26 Silver Bullet Therapeutics, Inc. Bone implants for the treatment of infection
US8221396B2 (en) * 2009-08-27 2012-07-17 Silver Bullet Therapeutics, Inc. Bone implants for the treatment of infection
US9248254B2 (en) 2009-08-27 2016-02-02 Silver Bullet Therapeutics, Inc. Bone implants for the treatment of infection
US9889284B2 (en) 2009-08-27 2018-02-13 Silver Bullet Therapeutics, Inc. Bone implant and systems that controllably releases silver
US9700304B2 (en) 2010-04-19 2017-07-11 Gold Thread Llc Filament implant system and method
US9789298B2 (en) 2010-11-12 2017-10-17 Silver Bullet Therapeutics, Inc. Bone implant and systems that controllably releases silver
US8771323B2 (en) 2010-11-12 2014-07-08 Silver Bullet Therapeutics, Inc. Bone implant and systems that controllably releases silver
US9108051B2 (en) 2010-11-12 2015-08-18 Silver Bullet Therapeutics, Inc. Bone implant and systems that controllably releases silver
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
US9114197B1 (en) 2014-06-11 2015-08-25 Silver Bullett Therapeutics, Inc. Coatings for the controllable release of antimicrobial metal ions
US9452242B2 (en) 2014-06-11 2016-09-27 Silver Bullet Therapeutics, Inc. Enhancement of antimicrobial silver, silver coatings, or silver platings
US8927004B1 (en) 2014-06-11 2015-01-06 Silver Bullet Therapeutics, Inc. Bioabsorbable substrates and systems that controllably release antimicrobial metal ions
US8999367B1 (en) 2014-06-11 2015-04-07 Silver Bullet Therapeutics, Inc. Bioabsorbable substrates and systems that controllably release antimicrobial metal ions
US9821094B2 (en) 2014-06-11 2017-11-21 Silver Bullet Therapeutics, Inc. Coatings for the controllable release of antimicrobial metal ions
US20170065805A1 (en) * 2015-09-04 2017-03-09 The Sotopelle Group, Llc Therapeutic trocar/inserter and method of use

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