WO2005000287A1 - 水虫治療用外用剤 - Google Patents
水虫治療用外用剤 Download PDFInfo
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- WO2005000287A1 WO2005000287A1 PCT/JP2004/008992 JP2004008992W WO2005000287A1 WO 2005000287 A1 WO2005000287 A1 WO 2005000287A1 JP 2004008992 W JP2004008992 W JP 2004008992W WO 2005000287 A1 WO2005000287 A1 WO 2005000287A1
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- Prior art keywords
- athlete
- external preparation
- foot
- menthol
- agent
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to an external preparation for athlete's foot treatment comprising as an essential component at least one compound selected from the group consisting of an anti-tineamyces drug, menthol, menthol-related compounds, and bactericidal compounds.
- antifungal drugs used in external preparations for treating athlete's foot various antifungal drugs such as imidazole, triazole, thiocarbamine, benzylamine, arylamine, and morpholine have been developed and marketed.
- antifungal drugs differ in their antifungal spectrum and antifungal activity, and have strong antibacterial activity across fungi such as Trichophyton and other fungi such as Candida.
- an external preparation having enhanced antifungal activity and the like by combining two or more antifungal agents that can be used has been reported (for example, see Patent Documents 11 to 13).
- an antifungal activity-enhancing composition containing an allylamine antifungal agent and menthol has been reported, which enhances the activity against so-called Trichophyton, and is effective against other fungi such as Candida. It does not enhance fungal activity (see, for example, Patent Document 4).
- an antifungal agent with a peripheral vasodilator see, for example, Patent Document 5
- an antifungal agent with an antifungal agent such as methyl salicylate, glycol salicylate, crotamiton, hatsune oil, 1-menthol, etc.
- an antifungal agent with an antifungal agent such as methyl salicylate, glycol salicylate, crotamiton, hatsune oil, 1-menthol, etc.
- Patent Document 6 a substance that improves keratin retention
- they do not exhibit excellent antifungal properties against other fungi such as Trichophyton and Candida.
- any of the external preparations disclosed in the above-mentioned documents promotes athlete's foot discomfort (itching, malodor, etc.), which does not indicate suppression of the growth of bacteria indigenous to the skin such as Staphylococcus aureus. No effect was observed when the indigenous skin bacteria such as Candida bacteria ⁇ Staphylococcus aureus caused abnormal growth. Was not raised enough.
- Patent Document 1 Japanese Patent Application Laid-Open No. 3-38222
- Patent Document 2 JP-A-9-176014
- Patent Document 3 Japanese Patent Application Laid-Open No. 2004-35411
- Patent Document 4 Japanese Patent Application Laid-Open No. 2004-149508
- Patent Document 5 Japanese Patent Application Laid-Open No. 7-233088
- Patent Document 6 JP-A-8-20527
- Anti-tineaphylas drugs such as butenafine hydrochloride alone have extremely excellent antifungal activity, but the present invention is aimed at improving patient compliance and further reducing symptoms such as redness.
- the present invention provides an external preparation for athlete's foot treatment that has more excellent effects.
- the inventors of the present invention have conducted intensive studies for improving patient compliance with an external preparation for treating athlete's foot, and as a result, selected from an anti-tinea bacillus drug, and menthol, menthol-related compounds, and fungicidal compounds.
- An external preparation containing at least one compound as an essential component effectively reduces not only Trichophyton, but also other fungi such as Candida, and skin-resident bacteria such as Staphylococcus aureus. was found.
- the present invention relates to an external preparation for athlete's foot treatment, comprising an anti-tineamyces drug and at least one compound selected from menthol, menthol-related compounds, and bactericidal compounds.
- the present invention provides 0.1 to 10% by mass of an anti-tineaphylococcal agent, 0.5% by mass of at least one compound selected from menthol, a menthol-related compound, and a bactericidal compound. % Of an external preparation for treating athlete's foot. Furthermore, the present invention relates to the above external preparation for athlete's foot treatment, which is menthol analogous physical strength 3_1-menthoxypropane 1,2-diol.
- the present invention relates to the above external preparation for treating athlete's foot, wherein the bactericidal compound is isopropylmethylphenol.
- the present invention relates to the external preparation for treating athlete's foot, wherein the anti-tineaplastic agent is selected from a pendinoleamine-based agent, an arylamine-based agent, a thiocarbamic acid-based agent, and an imidazole-based antifungal agent.
- the anti-tineaplastic agent is selected from a pendinoleamine-based agent, an arylamine-based agent, a thiocarbamic acid-based agent, and an imidazole-based antifungal agent.
- the present invention relates to the above external preparation for athlete's foot treatment, wherein the anti-tineaphytic agent is one selected from butenafine hydrochloride, terbinafine hydrochloride, tolnaftate, bifonazole, ketoconazole, neticonazole hydrochloride, and lanconazole.
- the anti-tineaphytic agent is one selected from butenafine hydrochloride, terbinafine hydrochloride, tolnaftate, bifonazole, ketoconazole, neticonazole hydrochloride, and lanconazole.
- the present invention relates to the above external preparation for treating athlete's foot, which comprises an anti-tineagle drug and 11-menthol.
- the present invention relates to an external preparation for treating athlete's foot, comprising butenafine hydrochloride, 1-menthol, and isopropylmethylphenol.
- the present invention also relates to the external preparation for treating athlete's foot, further comprising at least one or more of a local anesthetic, an antihistamine, and an anti-inflammatory agent.
- the present invention relates to the above external preparation for treating athlete's foot, wherein the local anesthetic is dibubuin hydrochloride or lidocaine or a salt thereof.
- the present invention relates to the aforementioned external preparation for treating athlete's foot, wherein the antihistamine is chlorpheniramine maleate or diphenhydramine or the like.
- the present invention relates to the above external preparation for treating athlete's foot, wherein the anti-inflammatory agent is glycyrrhetinic acid or a salt thereof, or allantoin.
- the present invention relates to the above external preparation for treating athlete's foot, which comprises butenafine hydrochloride, 1-menthol, dibubuin hydrochloride, chlorpheniramine maleate and glycyrrhetinic acid.
- the external preparation for athlete's foot treatment of the present invention is an anti-tineamycosis drug that does not always have sufficient antibacterial activity against fungi other than Trichophyton, and is a yellow grape that causes malodor of feet and aggravation of athlete's foot due to athlete's foot.
- Use of antifungal drugs in combination with the growth of skin-resident bacteria such as cocci and Candida It has the effect of increasing the therapeutic effect of athlete's foot and also improving patient compliance than simply reducing the Trichophyton.
- a compound selected from 1-menthol, a menthol-related compound, and a fungicidal compound is combined with one or more, and preferably two or more, to form a compound with an anti-tinea bacillus drug in a smaller amount. It was found that the growth of Staphylococcus aureus and Candida could be synergistically suppressed.
- the external preparation for the treatment of athlete's foot contains at least one or more of a local anesthetic, an antihistamine and an anti-inflammatory agent, it suppresses mild but rare occurrence of redness of the anti- ringworm bacterium, Further better compliance can be obtained.
- This effect can be obtained by combining at least one of a local anesthetic, an antihistamine, and an anti-inflammatory agent, but a more favorable effect can be obtained by using two or more thereof in combination.
- the external preparation for athlete's foot treatment preparations specific concentration of anti-trichophyton agents, i.e., 0. 1-10. 0 wt 0/0, preferably, 1 one 5 mass 0/0, and 1 one menthol, At least one compound selected from a menthol analog and a bactericidal compound is added in a total amount of 0.5% by mass to 5% by mass, preferably 1% by mass to 3% by mass.
- the anti-tineaphylas agents used in the present invention are benzylamine, arylamine, thiocarbamine, imidazole, and triazole antifungal agents.
- Butenafine hydrochloride has high activity against Trichophyton, but Candida It is not expected to have much activity against cocci. 1 By using it in combination with at least one compound selected from menthol, menthol-related compounds, and fungicidal compounds, not only Trichophyton but also Candida ⁇ yellow grape It is preferable because the activity against cocci can be synergistically increased.
- the compound used together with the anti-tinea ring drug is menthol, dl-menthol, 3-1-menthoxypropane-1,2-diol, isopulegol, neoisopulegol, or isoiso.
- Menthol analogs such as pulegol, neoisoisopulegol, neomenthol, isomenthol, neoisomenthol, citronellol, linalool, isopropylmethylphenol, decalinium chloride, decalinium acetate, benzethonium chloride, benzanolone chloride, chlorinine chloride, chlorhexine, dalcone
- suitable bactericidal compounds such as chlorhexine acid, hinokitiol and resorcinol, are 3-1-1 menthoxypropane-1,2-diol and isopropylmethylphenol.
- At least one compound selected from the group consisting of 1-menthol, a menthol-related compound, and a fungicidal compound is added in a total amount of 0.5% by mass or more to increase the growth of Candida and S. aureus. Is preferably set at 5% by mass or less, since the problem of difficulty in drying when used as a liquid does not occur.
- the type of antihistamine used in the present invention is preferably chlorpheniramine, a salt thereof, diphenhydramine or a salt thereof, promethazine, mequitazine, and the like. Chlorpheniramine, difendramin or a salt thereof is preferred. Les ,.
- the concentration of the antihistamine is 0. 05-5.
- Examples of the type of local anesthetic used in the present invention include lidocaine or a salt thereof, jib forcein or a salt thereof, tetracaine or a salt thereof, proforce in or a salt thereof, ethyl amino benzoate and the like.
- Strength Jib hydrochloride or lidocaine or its salts is preferred. Les ,.
- the concentration of the local anesthetic is preferably from 0.01 to 5.0% by weight, more preferably from 0.05 to 2.0% by weight.
- the types of anti-inflammatory agents used in the present invention include glycyrrhetinic acid or salts thereof, methyl salicylate, glycol salicinoleate, indomethacin, diclofenac, fuerbinac, piroxicam, ketoprofen, ibuprofen piconol, bufexamac, and allantoin.
- Power preferably glycyrrhetinic acid or its salts or allantoin.
- the concentration of the anti-inflammatory agent is preferably 0.05 to 10.0 mass%, more preferably 0.05 to 2.
- a formulation in which dibucaine hydrochloride, chlorpheniramine maleate and glycyrrhetinic acid are blended with an external preparation for athlete's foot treatment consisting of butenafine hydrochloride and 11-menthol is particularly preferable because it can improve compliance synergistically.
- the external preparation referred to in the present invention includes a liquid preparation, a cream, a lotion, an aerosol, a patch and the like.
- the external preparation of the present invention can contain a conventional base depending on the form, and in the case of a liquid preparation or a lotion, can contain a lower alcohol, a polyhydric alcohol, water and the like.
- Aerosols can include lower alcohols, polyhydric alcohols, and the like that dissolve the agent of the present invention.
- Examples of the lower alcohol used in the above formulation include methanol, ethanol, denatured ethanol, and isopropanol.
- oily base examples include liquid paraffin, petrolatum, paraffin wax and the like, and the higher alcohol is an alcohol having 10 to 20 carbon atoms, preferably cetyl alcohol, stearyl alcohol, cetostearyl alcohol, or oleyl alcohol.
- polyhydric alcohols and derivatives thereof include glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, and esters or ethers thereof.
- Fatty acid esters are esters of higher fatty acids, and include esters of higher fatty acids such as myristic acid, palmitic acid, stearic acid, and oleic acid, and lower alcohols (1-16 carbon atoms).
- Surfactants include anionic surfactants such as polyoxyethylene alkyl phosphate, sodium alkyl sulfate, sorbitan sesquioleate, sorbitan trioleate, sorbitan monostearate, sorbitan monolaurate, and polyoxyethylene.
- anionic surfactants such as sorbitan fatty acid esters such as sorbitan stearate, or polyoxyethylene ethers such as polyoxyethylene nonyl ether, monooxyethylene cetyl ether, and monooxyethylene lauryl ether; and other chlorides.
- Cationic or amphoteric surfactants such as zetonium and benzalkonium chloride may be used.
- gelling agent examples include carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypinolenosenorelose, methinoresenololose, etinoresenololose, and canoleboxy methinoresenorelose.
- the external preparation for treating athlete's foot of the present invention may contain a percutaneous absorption enhancer.
- the percutaneous absorption enhancer may be one or two of which the percutaneous absorption promoting effect of an anti-tineauresis agent is recognized. If it is more than one kind of compound, it may be out of place.
- 620 carbon fatty acids, fatty alcohols, fatty acid esters or ethers Ter, aromatic organic acid, aromatic alcohol, aromatic organic acid ester or ether, lactate ester, acetate ester, monoterpene compound, sesquiterpene compound, Azone (Azone) or its derivative
- Fatty acid esters and fatty alcohols are preferred, with isopropynole myristate, isopropyl palmitate, sorbitan monooleate and oleyl alcohol being particularly preferred.
- the external preparation for athlete's foot treatment of the present invention may contain an antioxidant, a preservative, a preservative, a humectant, a chelating agent, and other additives usually contained in a skin external preparation.
- Example 16-16 The solid component is dissolved in ethanol, and the other components are added thereto to produce a stock solution.
- the undiluted solution and the propellant were filled in an aerosol can to obtain the aerosol preparation of Example 16-16.
- the aqueous phase and the oil phase are each heated to 80 ° C. and mixed and emulsified while sufficiently stirring. Thereafter, the mixture was cooled to room temperature with stirring to obtain a cream of Examples 7-9.
- the liquid was prepared by dissolving the active ingredient in ethanol and adding other components to the solution to obtain liquids of Examples: 0 to 17 and Comparative Examples 13 to 13.
- Examples 10-12 and Comparative Example 1 were applied to 20 patients with dermatomycosis, and the number of persons who obtained a feeling of coolness and sensation (especially relief of itch) was shown.
- Test Example 2 Evaluation of antibacterial activity by halo test
- inoculated with SCD agar test bacteria was cooled to an appropriate temperature after autoclaving (Staphylococcus aureus, Candida albicans), it was adjusted to about 10 6 ZML.
- test bacterium cultured in 1. was thinly layered on the SCD agar medium prepared beforehand, and cooled and solidified at room temperature.
- the amount of menthol is set in 7 levels between 0-4%.
- Antibacterial activity was confirmed at a ratio of 0.5% or more against Candida and 1% or more against Staphylococcus aureus.
- the antimicrobial activity was evaluated by the halo test using the formulations of Examples 13 to 17 and Comparative Examples 13 to 13 shown in Table 4.
- the test method was the same as in Test Example 2, and the results are shown below.
- Antibacterial activity against Staphylococcus aureus and Candida was confirmed at a concentration of 0.5% or more of 3_1-menthoxypropane-1,2-diol.
- a formulation containing a combination of isopropylmethylphenol and 1-menthol could effectively suppress S. aureus and Candida.
- an external preparation for the treatment of athlete's foot which contains as an essential component an anti-ringworm drug and a compound that suppresses the growth of Staphylococcus aureus and Candida bacteria, other fungi such as Trichophyton, S. aureus, and yellow grape It also enables effective elimination of skin-resident bacteria such as cocci, and can be applied to a wide range of uses such as treatment of fungal infections.
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Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE602004029465T DE602004029465D1 (de) | 2003-06-25 | 2004-06-25 | Externes Präparat zur Behandlung von Fusspilz |
JP2005511050A JPWO2005000287A1 (ja) | 2003-06-25 | 2004-06-25 | 水虫治療用外用剤 |
EP04746461A EP1637132B1 (en) | 2003-06-25 | 2004-06-25 | External preparation for athlete´s foot treatment |
US10/561,499 US20070099932A1 (en) | 2003-06-25 | 2004-06-25 | External preparation for athlete's foot treatment |
US12/338,096 US20090099202A1 (en) | 2003-06-25 | 2008-12-18 | External Preparation for Athlete's Foot Treatment |
US13/183,621 US8664224B2 (en) | 2003-06-25 | 2011-07-15 | External preparation for athlete's foot treatment |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003181264 | 2003-06-25 | ||
JP2003-181264 | 2003-06-25 | ||
JP2003-407136 | 2003-12-05 | ||
JP2003407136 | 2003-12-05 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/561,499 A-371-Of-International US20070099932A1 (en) | 2003-06-25 | 2004-06-25 | External preparation for athlete's foot treatment |
US12/338,096 Continuation US20090099202A1 (en) | 2003-06-25 | 2008-12-18 | External Preparation for Athlete's Foot Treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005000287A1 true WO2005000287A1 (ja) | 2005-01-06 |
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ID=33554443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2004/008992 WO2005000287A1 (ja) | 2003-06-25 | 2004-06-25 | 水虫治療用外用剤 |
Country Status (5)
Country | Link |
---|---|
US (3) | US20070099932A1 (ja) |
EP (1) | EP1637132B1 (ja) |
JP (3) | JPWO2005000287A1 (ja) |
DE (1) | DE602004029465D1 (ja) |
WO (1) | WO2005000287A1 (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007091661A (ja) * | 2005-09-29 | 2007-04-12 | Nippon Nohyaku Co Ltd | 外用抗真菌剤組成物 |
JP2007182385A (ja) * | 2005-12-29 | 2007-07-19 | Rohto Pharmaceut Co Ltd | カンジダ症の予防又は治療用組成物 |
JP2007291049A (ja) * | 2006-04-27 | 2007-11-08 | Adeka Corp | 抗菌剤及びこれを含有する抗菌性組成物 |
JP2008069109A (ja) * | 2006-09-14 | 2008-03-27 | Ikeda Mohandou:Kk | 外用医薬組成物 |
JP2008156346A (ja) * | 2006-11-29 | 2008-07-10 | Rohto Pharmaceut Co Ltd | 抗真菌医薬組成物 |
JP2009007365A (ja) * | 2003-06-25 | 2009-01-15 | Hisamitsu Pharmaceut Co Inc | 水虫治療用外用剤 |
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JP2009007365A (ja) * | 2003-06-25 | 2009-01-15 | Hisamitsu Pharmaceut Co Inc | 水虫治療用外用剤 |
JP2007091661A (ja) * | 2005-09-29 | 2007-04-12 | Nippon Nohyaku Co Ltd | 外用抗真菌剤組成物 |
JP2007182385A (ja) * | 2005-12-29 | 2007-07-19 | Rohto Pharmaceut Co Ltd | カンジダ症の予防又は治療用組成物 |
JP2007291049A (ja) * | 2006-04-27 | 2007-11-08 | Adeka Corp | 抗菌剤及びこれを含有する抗菌性組成物 |
JP2008069109A (ja) * | 2006-09-14 | 2008-03-27 | Ikeda Mohandou:Kk | 外用医薬組成物 |
JP2013163679A (ja) * | 2006-11-29 | 2013-08-22 | Rohto Pharmaceutical Co Ltd | 抗真菌医薬組成物 |
JP2008156346A (ja) * | 2006-11-29 | 2008-07-10 | Rohto Pharmaceut Co Ltd | 抗真菌医薬組成物 |
JP2016166238A (ja) * | 2006-11-29 | 2016-09-15 | ロート製薬株式会社 | 抗真菌医薬組成物 |
JP2014205725A (ja) * | 2006-11-29 | 2014-10-30 | ロート製薬株式会社 | 抗真菌医薬組成物 |
EP2266553A1 (en) * | 2008-04-08 | 2010-12-29 | Teikoku Seiyaku Co., Ltd. | Butenafine hydrochloride-containing aqueous patch |
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JP2012126733A (ja) * | 2012-03-15 | 2012-07-05 | Ikeda Mohando:Kk | 外用医薬組成物 |
Also Published As
Publication number | Publication date |
---|---|
US8664224B2 (en) | 2014-03-04 |
US20110269794A1 (en) | 2011-11-03 |
JP4828563B2 (ja) | 2011-11-30 |
EP1637132B1 (en) | 2010-10-06 |
EP1637132A1 (en) | 2006-03-22 |
JP2009007365A (ja) | 2009-01-15 |
EP1637132A4 (en) | 2008-01-09 |
US20090099202A1 (en) | 2009-04-16 |
DE602004029465D1 (de) | 2010-11-18 |
JPWO2005000287A1 (ja) | 2006-10-05 |
JP2008239626A (ja) | 2008-10-09 |
US20070099932A1 (en) | 2007-05-03 |
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