JP2007262030A - 皮膚外用剤 - Google Patents
皮膚外用剤 Download PDFInfo
- Publication number
- JP2007262030A JP2007262030A JP2006092523A JP2006092523A JP2007262030A JP 2007262030 A JP2007262030 A JP 2007262030A JP 2006092523 A JP2006092523 A JP 2006092523A JP 2006092523 A JP2006092523 A JP 2006092523A JP 2007262030 A JP2007262030 A JP 2007262030A
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- skin
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- lower alcohol
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Abstract
【解決手段】局所麻酔剤(リドカイン等)0.3〜5重量%、尿素3〜20重量%、清涼化剤(メントール、カンフル等)3〜11重量%、低級アルコール(エタノール、無水エタノール等)12〜40重量%及び水を含有する皮膚外用剤。
【効果】かゆみを素早く他の感覚(清涼感、灼熱感)に置換し、かゆみを抑制し、これらの置換、抑制作用が持続する。
【選択図】なし
Description
項1.局所麻酔剤0.3〜5重量%、尿素3〜20重量%、清涼化剤3〜11重量%、低級アルコール12〜40重量%及び水を含有する皮膚外用剤。
項2.皮膚外用剤に含有される水及び低級アルコールの重量比率が水/低級アルコールで表すと0.6〜7.0である項1に記載の皮膚外用剤。
項3.局所麻酔剤がリドカイン、ジブカイン、プロカイン又はこれらの塩、アミノ安息香酸エチル及びテシットデシチンからなる群から選択される1種又は2種以上である項1又は2に記載の皮膚外用剤。
項4.清涼化剤がl−メントール、dl−メントール、d−カンフル、dl−カンフル、薄荷油及び樟脳油からなる群から選択される1種又は2種以上である項1〜3のいずれかに記載の皮膚外用剤。
項5.低級アルコールが無水エタノール、エタノール、メタノール及びイソプロパノールからなる群から選択される1種又は2種以上である項1〜4のいずれかに記載の皮膚外用剤。
項6.低級アルコール含有量が20〜39重量%である項1〜5のいずれかに記載の皮膚外用剤。
項7.ゲル剤である項1〜6のいずれかに記載の皮膚外用剤。
項8.掻痒感改善用である項1〜7のいずれかに記載の皮膚外用剤。
項9.知覚過敏型掻痒感改善用である項1〜8のいずれかに記載の皮膚外用剤。
表1に示す成分、すなわち局所麻酔剤(リドカイン)2重量%、尿素10重量%、清涼化剤(l−メントール)4重量%、低級アルコール(無水エタノール)12重量%、水67重量%、ジフェンヒドラミン1重量%、CVP(カルボキシビニルポリマー)1重量%及びグリセリン3重量%を含有するゲル剤を製造した。すなわち、水に尿素を溶解し、撹拌しながらCVPを加えて水相を調製し、水相とは別に無水エタノールにリドカイン、l−メントール、ジフェンヒドラミン、グリセリンを溶解、混和して有機相を調製し、水相を撹拌しながらここに有機相を徐々に添加し、撹拌混合してゲル剤を調製した。
表2及び3に示す成分を使用し、実施例1と同様にしてゲル剤を製造した。
表1に示す成分を使用し、実施例1と同様にしてゲル剤を製造した。
ジフェンヒドラミン、リドカイン、l−メントール、モノステアリン酸グリセリルを混合し、加熱溶解し、油相を製造した。これとは別に、水、尿素、エタノール及びグリセリンを混合し、加熱溶解し、ここに油相を加えた。撹拌しながらカルボキシビニルポリマー、トリエタノールアミンを加えて乳剤を製造した。
表1に示す成分を使用し、ワセリンを40〜60℃に加温し液状になったところに各成分を加え、撹拌混合し、冷却して油系軟膏剤を製造した。
実施例1〜14及び比較例1〜7のゲル剤、比較例8の乳剤、比較例9の軟膏剤を使用して皮膚のかゆみに関する官能試験を行った。皮膚が乾燥肌でない健常な状態の者を被験者(6名)とし、被験者がかゆみを発生した時にかゆみの発生した部位に実施例及び比較例の製剤を塗布してもらい、SD法などで用いられる意味尺度を利用して5段階(最低1点、最高5点)で評価をしてもらった。評価項目及び評価方法は次のとおりである。結果を表に示した。なお、表中、CVPはカルボキシビニルポリマー、DPGはジプロピレングリコール、PGはポリエチレングリコールを意味する。
かゆみ以外の感覚(清涼感/灼熱感)の強さ
かゆみ以外の感覚(清涼感/灼熱感)の速さ
かゆみの抑制効果
かゆみ以外の感覚及びかゆみ抑制効果の持続性
評価方法
被験者6名のつけた5段階評価の点の合計点を次の区分で表した。
◎:24〜30点
○:18〜23点
△:12〜17点
×:6〜11点
表4に示した組成を、常法によりクリーム剤、乳剤、液剤、エアゾール剤、ゲル剤に製した。なお、エアゾール剤は、薬液:噴射剤=1:4でアルミ缶に充填し、エアゾール剤とした。また、表中、BHTはジブチルヒドロキシトルエンを意味する。
Claims (9)
- 局所麻酔剤0.3〜5重量%、尿素3〜20重量%、清涼化剤3〜11重量%、低級アルコール12〜40重量%及び水を含有する皮膚外用剤。
- 皮膚外用剤に含有される水及び低級アルコールの重量比率が水/低級アルコールで表すと0.6〜7.0である請求項1に記載の皮膚外用剤。
- 局所麻酔剤がリドカイン、ジブカイン、プロカイン又はこれらの塩、アミノ安息香酸エチル及びテシットデシチンからなる群から選択される1種又は2種以上である請求項1又は2に記載の皮膚外用剤。
- 清涼化剤がl−メントール、dl−メントール、d−カンフル、dl−カンフル、薄荷油及び樟脳油からなる群から選択される1種又は2種以上である請求項1〜3のいずれかに記載の皮膚外用剤。
- 低級アルコールが無水エタノール、エタノール、メタノール及びイソプロパノールからなる群から選択される1種又は2種以上である請求項1〜4のいずれかに記載の皮膚外用剤。
- 低級アルコール含有量が20〜39重量%である請求項1〜5のいずれかに記載の皮膚外用剤。
- ゲル剤である請求項1〜6のいずれかに記載の皮膚外用剤。
- 掻痒感改善用である請求項1〜7のいずれかに記載の皮膚外用剤。
- 知覚過敏型掻痒感改善用である請求項1〜8のいずれかに記載の皮膚外用剤。
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JP2009280511A (ja) * | 2008-05-20 | 2009-12-03 | Otsuka Pharmaceut Factory Inc | 皮膚外用かゆみ止め剤 |
WO2011001676A1 (ja) | 2009-07-02 | 2011-01-06 | 国立大学法人山口大学 | 表面麻酔剤 |
JP2012240944A (ja) * | 2011-05-18 | 2012-12-10 | Kuroisutaazu :Kk | 皮膚外用剤 |
KR20220026405A (ko) * | 2020-08-25 | 2022-03-04 | 이나래 | 항문 소양증의 완화 및 치료용 조성물 및 이를 포함하는 항문 패드 |
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JP2009280511A (ja) * | 2008-05-20 | 2009-12-03 | Otsuka Pharmaceut Factory Inc | 皮膚外用かゆみ止め剤 |
WO2011001676A1 (ja) | 2009-07-02 | 2011-01-06 | 国立大学法人山口大学 | 表面麻酔剤 |
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JP2012240944A (ja) * | 2011-05-18 | 2012-12-10 | Kuroisutaazu :Kk | 皮膚外用剤 |
KR20220026405A (ko) * | 2020-08-25 | 2022-03-04 | 이나래 | 항문 소양증의 완화 및 치료용 조성물 및 이를 포함하는 항문 패드 |
KR102597992B1 (ko) * | 2020-08-25 | 2023-11-06 | 이나래 | 항문 소양증의 완화 및 치료용 조성물 및 이를 포함하는 항문 패드 |
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