WO2003064383A2 - Phosphorus-containing compounds & uses thereof - Google Patents
Phosphorus-containing compounds & uses thereof Download PDFInfo
- Publication number
- WO2003064383A2 WO2003064383A2 PCT/US2003/003030 US0303030W WO03064383A2 WO 2003064383 A2 WO2003064383 A2 WO 2003064383A2 US 0303030 W US0303030 W US 0303030W WO 03064383 A2 WO03064383 A2 WO 03064383A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- moiety
- independently
- occurrence
- aryl
- Prior art date
Links
- 0 C[C@](Cc(cc1)cc(OC)c1OI)[C@](CC([C@](C)C=C(C)[C@]([C@](C([C@](C)C[C@](C)C=CC=CC=C(C)[C@](*)CC(CC[C@]1C)*[C@]1(C(C(N1C2CCCC1)=O)=O)O)=O)OC)O)=O)OC2=O Chemical compound C[C@](Cc(cc1)cc(OC)c1OI)[C@](CC([C@](C)C=C(C)[C@]([C@](C([C@](C)C[C@](C)C=CC=CC=C(C)[C@](*)CC(CC[C@]1C)*[C@]1(C(C(N1C2CCCC1)=O)=O)O)=O)OC)O)=O)OC2=O 0.000 description 4
- UDQGDAHTUQCRBY-PEZBUJJGSA-N CC(C)(C)/C=C(/CCc1ccccc1)\CCOC Chemical compound CC(C)(C)/C=C(/CCc1ccccc1)\CCOC UDQGDAHTUQCRBY-PEZBUJJGSA-N 0.000 description 1
- NVDFYFKMMZFUNE-UHFFFAOYSA-N CC(C)(C)N1OCCCO1 Chemical compound CC(C)(C)N1OCCCO1 NVDFYFKMMZFUNE-UHFFFAOYSA-N 0.000 description 1
- OGTRQDOKNDBMMV-UHFFFAOYSA-N CC(C)(C[O]1CCOCCNC)P1(OCCOCCOC)=O Chemical compound CC(C)(C[O]1CCOCCNC)P1(OCCOCCOC)=O OGTRQDOKNDBMMV-UHFFFAOYSA-N 0.000 description 1
- CGNVCNBGLPQQDZ-NJNHOYGRSA-N CCCOP(C)(O[C@H](CC[C@@H](C[C@@H](C)[C@H](CC([C@H](C)/C=C(\C)/[C@H]([C@H](C(C(C)C[C@H](C)/C=C/C=C/C=C(\C)/[C@H](C[C@H](CC[C@H]1C)O[C@]1(C(C(N1C2CCCC1)=O)=O)O)OC)=O)OC)O)=O)OC2=O)C1)[C@@H]1OC)=O Chemical compound CCCOP(C)(O[C@H](CC[C@@H](C[C@@H](C)[C@H](CC([C@H](C)/C=C(\C)/[C@H]([C@H](C(C(C)C[C@H](C)/C=C/C=C/C=C(\C)/[C@H](C[C@H](CC[C@H]1C)O[C@]1(C(C(N1C2CCCC1)=O)=O)O)OC)=O)OC)O)=O)OC2=O)C1)[C@@H]1OC)=O CGNVCNBGLPQQDZ-NJNHOYGRSA-N 0.000 description 1
- BUROJSBIWGDYCN-XTRHDYNXSA-N C[C@H](CC(CC[C@H]1OP(C)(C)=O)CC1OC)[C@H](CC([C@H](C)/C=C(\C)/C([C@H](C(C(C)C[C@H](C)/C=C/C=C/C=C(\C)/[C@H](C[C@H](CCC1C)OC1(C(C(N1C2CCCC1)=O)=O)O)OC)=O)OC)O)=O)OC2=O Chemical compound C[C@H](CC(CC[C@H]1OP(C)(C)=O)CC1OC)[C@H](CC([C@H](C)/C=C(\C)/C([C@H](C(C(C)C[C@H](C)/C=C/C=C/C=C(\C)/[C@H](C[C@H](CCC1C)OC1(C(C(N1C2CCCC1)=O)=O)O)OC)=O)OC)O)=O)OC2=O BUROJSBIWGDYCN-XTRHDYNXSA-N 0.000 description 1
- ONPZMTBFHFTVIN-UHFFFAOYSA-N OC(C1SCCCC1)=O Chemical compound OC(C1SCCCC1)=O ONPZMTBFHFTVIN-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P17/04—Antipruritics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P27/02—Ophthalmic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003564006A JP4547911B2 (ja) | 2002-02-01 | 2003-02-03 | リン含有化合物およびその用途 |
| AU2003210787A AU2003210787B2 (en) | 2002-02-01 | 2003-02-03 | Phosphorus-containing compounds & uses thereof |
| DK03735110T DK1478648T3 (da) | 2002-02-01 | 2003-02-03 | Phosphorholdige forbindelser og anvendelser deraf |
| KR20047011867A KR100956195B1 (ko) | 2002-02-01 | 2003-02-03 | 인 함유 화합물 및 이의 용도 |
| MXPA04007402A MXPA04007402A (es) | 2002-02-01 | 2003-02-03 | Compuestos que contienen fosforo y usos de los mismos. |
| BR0307544A BR0307544A (pt) | 2002-02-01 | 2003-02-03 | Compostos contendo fósforos, componentes e composição bem como, sua utilização através de métodos de tratamentos |
| EP20030735110 EP1478648B1 (en) | 2002-02-01 | 2003-02-03 | Phosphorus-containing compounds and uses thereof |
| IL16273403A IL162734A0 (en) | 2002-02-01 | 2003-02-03 | Phosphorus-containing compounds & uses thereof |
| EA200401008A EA008379B1 (ru) | 2002-02-01 | 2003-02-03 | Фосфорсодержащие соединения и их применения |
| ES03735110.3T ES2485841T3 (es) | 2002-02-01 | 2003-02-03 | Compuestos que contienen fósforo y usos de los mismos |
| CA2472341A CA2472341C (en) | 2002-02-01 | 2003-02-03 | Phosphorus-containing compounds & uses thereof |
| IL162734A IL162734A (en) | 2002-02-01 | 2004-06-24 | Compounds containing phosphorus and their use |
| IL199153A IL199153A (en) | 2002-02-01 | 2009-06-04 | Compounds containing phosphorus and their use |
| AU2009202913A AU2009202913B2 (en) | 2002-02-01 | 2009-07-20 | Phosphorus-containing compounds & uses thereof |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35325202P | 2002-02-01 | 2002-02-01 | |
| US60/353,252 | 2002-02-01 | ||
| US42692802P | 2002-11-15 | 2002-11-15 | |
| US60/426,928 | 2002-11-15 | ||
| US42838302P | 2002-11-22 | 2002-11-22 | |
| US60/428,383 | 2002-11-22 | ||
| US43393002P | 2002-12-17 | 2002-12-17 | |
| US60/433,930 | 2002-12-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2003064383A2 true WO2003064383A2 (en) | 2003-08-07 |
| WO2003064383A3 WO2003064383A3 (en) | 2004-01-22 |
Family
ID=27671080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2003/003030 WO2003064383A2 (en) | 2002-02-01 | 2003-02-03 | Phosphorus-containing compounds & uses thereof |
Country Status (16)
Cited By (202)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004096236A2 (en) * | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Immunomodulator phosphonate conjugates |
| WO2005049021A1 (en) * | 2003-11-03 | 2005-06-02 | Oy Helsinki Transplantation R & D Ltd | Materials and methods for inhibiting neointimal hyperplasia |
| WO2005053661A2 (en) * | 2003-12-01 | 2005-06-16 | Novartis Ag | Pharmaceutical combinations |
| EP1543850A1 (en) * | 2003-12-17 | 2005-06-22 | Cordis Neurovascular, Inc. | Activatable bioactive implantable medical device |
| EP1543849A1 (en) * | 2003-12-17 | 2005-06-22 | Cordis Neurovascular, Inc. | Activatable bioactive implantable medical device |
| EP1648900A2 (en) * | 2003-07-11 | 2006-04-26 | Ariad Gene Therapeutics, Inc. | Phosphorus-containing macrocycles |
| US7091213B2 (en) | 2002-02-01 | 2006-08-15 | Ariad Gene Therapeutics, Inc. | Phosphorus-containing compounds and uses thereof |
| WO2006128660A1 (en) * | 2005-05-31 | 2006-12-07 | Novartis Ag | Combination of hmg-coa reductase inhibitors amd mtor inhibitors |
| US7244261B2 (en) | 2004-04-08 | 2007-07-17 | Cordis Neurovascular, Inc. | Activatable bioactive vascular occlusive device |
| US7273717B2 (en) | 2003-10-24 | 2007-09-25 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds with GS-9005 ester hydrolase B |
| US7300924B2 (en) | 2003-04-25 | 2007-11-27 | Gilead Sciences, Inc. | Anti-infective phosphonate analogs |
| WO2007135411A1 (en) * | 2006-05-19 | 2007-11-29 | Biotica Technology Ltd. | 39-desmethoxy-39-methyl derivatives of rapamycin. |
| WO2008033956A2 (en) | 2006-09-13 | 2008-03-20 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| JP2008532991A (ja) * | 2005-03-11 | 2008-08-21 | バイオティカ テクノロジー リミテッド | ラパマイシンの３９−デスメトキシ誘導体 |
| US7417055B2 (en) | 2003-04-25 | 2008-08-26 | Gilead Sciences, Inc. | Kinase inhibitory phosphonate analogs |
| US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| US7427624B2 (en) | 2003-10-24 | 2008-09-23 | Gilead Sciences, Inc. | Purine nucleoside phosphorylase inhibitory phosphonate compounds |
| US7429565B2 (en) | 2003-04-25 | 2008-09-30 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
| US7432273B2 (en) | 2003-10-24 | 2008-10-07 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| US7432272B2 (en) | 2003-12-22 | 2008-10-07 | Gilead Sciences, Inc. | Antiviral analogs |
| US7432277B2 (en) | 2002-02-01 | 2008-10-07 | Araid Gene Therapeutics, Inc. | Phosphorus-containing macrocycles |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| US7462608B2 (en) | 2002-04-26 | 2008-12-09 | Gilead Sciences, Inc. | Non nucleoside reverse transcriptase inhibitors |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| EP2022498A2 (en) | 2005-11-21 | 2009-02-11 | Novartis AG | Neuroendocrine tumour treatment |
| WO2009054001A1 (en) * | 2007-10-22 | 2009-04-30 | Biocon Limited | A pharmaceutical composition and a process thereof |
| US7645747B2 (en) | 2003-04-25 | 2010-01-12 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| EP2206704A1 (en) | 2005-04-19 | 2010-07-14 | Novartis AG | Pharmaceutically active diazepanes |
| WO2011002887A1 (en) | 2009-07-02 | 2011-01-06 | Schering Corporation | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS |
| WO2011024168A2 (en) | 2009-08-26 | 2011-03-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd | Sustained release delivery systems for the prevention and treatment of head and neck cancers |
| WO2011050016A1 (en) | 2009-10-23 | 2011-04-28 | Eli Lilly And Company | Akt inhibitors |
| EP2332577A1 (en) | 2005-10-26 | 2011-06-15 | Novartis AG | Novel use of IL-1beta compounds |
| WO2011120911A1 (en) | 2010-03-30 | 2011-10-06 | Novartis Ag | Pkc inhibitors for the treatment of b-cell lymphoma having chronic active b-cell-receptor signalling |
| US8088789B2 (en) | 2006-09-13 | 2012-01-03 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| WO2012022814A1 (en) | 2010-08-20 | 2012-02-23 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) |
| WO2012027236A1 (en) | 2010-08-23 | 2012-03-01 | Schering Corporation | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
| WO2012061907A2 (en) | 2010-11-10 | 2012-05-18 | Katholieke Universiteit Leuven | Osteoclast activity |
| EP2455104A1 (en) | 2010-11-19 | 2012-05-23 | Universitätsklinikum Freiburg | Bio-functionalized stimulus-responsive dissolvable PEG-hydrogels |
| EP2468301A1 (en) | 2007-05-29 | 2012-06-27 | Novartis AG | New indications for anti-IL-1-beta therapy |
| WO2012145471A1 (en) | 2011-04-21 | 2012-10-26 | Merck Sharp & Dohme Corp. | Insulin-like growth factor-1 receptor inhibitors |
| WO2013016164A1 (en) | 2011-07-26 | 2013-01-31 | Merck Sharp & Dohme Corp. | FUSED TRICYCLIC COMPOUNDS AS mTOR INHIBITORS |
| WO2013082282A1 (en) | 2011-12-02 | 2013-06-06 | lNOVARTIS AG | Anti-il-1beta (interleukin-1beta) antibody-based prophylactic therapy to prevent complications leading to vaso-occlusion in sickle cell disease. |
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| WO2013084148A2 (en) | 2011-12-05 | 2013-06-13 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) directed to domain ii of her3 |
| WO2013105022A2 (en) | 2012-01-09 | 2013-07-18 | Novartis Ag | Organic compositions to treat beta-catenin-related diseases |
| US8496967B2 (en) | 2006-11-14 | 2013-07-30 | Ariad Pharmaceuticals, Inc. | Oral formulations |
| US8507518B2 (en) | 2003-11-04 | 2013-08-13 | Mayo Foundation For Medical Education And Research | Method of treating mantle cell lymphoma |
| WO2013138871A1 (en) | 2012-03-23 | 2013-09-26 | The University Of Queensland | Immunomodulatory agent and uses therefor |
| EP2662082A1 (en) | 2005-11-14 | 2013-11-13 | Ariad Pharmaceuticals, Incorporated | Administration of mTOR inhibitors |
| EP2762142A1 (en) | 2009-10-30 | 2014-08-06 | ARIAD Pharmaceuticals, Inc. | Compositions for treating cancer |
| WO2014130657A1 (en) | 2013-02-20 | 2014-08-28 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
| WO2014153270A1 (en) | 2013-03-16 | 2014-09-25 | Novartis Ag | Treatment of cancer using humanized anti-cd19 chimeric antigen receptor |
| WO2014160160A2 (en) | 2013-03-13 | 2014-10-02 | Novartis Ag | Antibody drug conjugates |
| WO2014184734A1 (en) | 2013-05-14 | 2014-11-20 | Novartis Ag | Markers associated with mtor inhibition |
| US8921642B2 (en) | 2008-01-11 | 2014-12-30 | Massachusetts Eye And Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
| US8951986B2 (en) | 2008-07-08 | 2015-02-10 | Gilead Sciences, Inc. | Salts of HIV inhibitor compounds |
| WO2015044854A1 (en) | 2013-09-24 | 2015-04-02 | Novartis Ag | Markers associated with mtor inhibition |
| EP2878312A1 (en) | 2013-12-02 | 2015-06-03 | Albert-Ludwigs-Universität Freiburg | Reversible PEGylation of nanocarriers |
| WO2015092634A1 (en) | 2013-12-16 | 2015-06-25 | Novartis Ag | 1,2,3,4-tetrahydroisoquinoline compounds and compositions as selective estrogen receptor antagonists and degraders |
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- 2003-02-03 US US10/357,152 patent/US20030220297A1/en not_active Abandoned
- 2003-02-03 PL PL371526A patent/PL216224B1/pl unknown
- 2003-02-03 PT PT03735110T patent/PT1478648E/pt unknown
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