WO2003008571A3 - Cadenas quiméricas codificantes para proteínas inductoras de efectos contra virus - Google Patents

Cadenas quiméricas codificantes para proteínas inductoras de efectos contra virus Download PDF

Info

Publication number
WO2003008571A3
WO2003008571A3 PCT/CU2002/000006 CU0200006W WO03008571A3 WO 2003008571 A3 WO2003008571 A3 WO 2003008571A3 CU 0200006 W CU0200006 W CU 0200006W WO 03008571 A3 WO03008571 A3 WO 03008571A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
specific
code
chimeric
serotype
Prior art date
Application number
PCT/CU2002/000006
Other languages
English (en)
French (fr)
Other versions
WO2003008571A9 (es
WO2003008571A2 (es
Inventor
Cruz Lisset Hermida
Diaz Rayner Rodriguez
Vazquez Laura Lazo
Morales Aida Zulueta
Abarrategui Carlos Lopez
Prado Iris Valdes
Rodriguez Ricardo De La Silva
Santiago Glay Chinea
Nieto Gerardo Enrique Guillen
Tirado Maria Guadalupe Guzman
Vazquez Beatriz De La C Sierra
Perez Raul Rafael Espinosa
Original Assignee
Ct Ingenieria Genetica Biotech
Inst De Medicina Tropical Pedr
Cruz Lisset Hermida
Diaz Rayner Rodriguez
Vazquez Laura Lazo
Morales Aida Zulueta
Abarrategui Carlos Lopez
Prado Iris Valdes
Rodriguez Ricardo De La Silva
Santiago Glay Chinea
Nieto Gerardo Enrique Guillen
Tirado Maria Guadalupe Guzman
Vazquez Beatriz De La C Sierra
Perez Raul Rafael Espinosa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP02760073A priority Critical patent/EP1418180B1/en
Priority to JP2003514888A priority patent/JP4417712B2/ja
Priority to DE60217129T priority patent/DE60217129T2/de
Priority to CA2453300A priority patent/CA2453300C/en
Priority to DK02760073T priority patent/DK1418180T3/da
Priority to BR0211178-0A priority patent/BR0211178A/pt
Priority to MXPA04000486A priority patent/MXPA04000486A/es
Priority to US10/484,114 priority patent/US7279164B2/en
Application filed by Ct Ingenieria Genetica Biotech, Inst De Medicina Tropical Pedr, Cruz Lisset Hermida, Diaz Rayner Rodriguez, Vazquez Laura Lazo, Morales Aida Zulueta, Abarrategui Carlos Lopez, Prado Iris Valdes, Rodriguez Ricardo De La Silva, Santiago Glay Chinea, Nieto Gerardo Enrique Guillen, Tirado Maria Guadalupe Guzman, Vazquez Beatriz De La C Sierra, Perez Raul Rafael Espinosa filed Critical Ct Ingenieria Genetica Biotech
Publication of WO2003008571A2 publication Critical patent/WO2003008571A2/es
Publication of WO2003008571A3 publication Critical patent/WO2003008571A3/es
Publication of WO2003008571A9 publication Critical patent/WO2003008571A9/es
Priority to US11/705,696 priority patent/US7566457B2/en
Priority to US12/483,607 priority patent/US7947281B2/en
Priority to US13/094,287 priority patent/US8105606B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Obtención de cadenas quiméricas codificantes para proteínas que inducen en el receptor efectos contra virus, las cuales estimulan la producción de una respuesta humoral serotipo especifica y protección frente a la infección por los virus del Dengue, evitándose los efectos de amplificación viral serotipo inespecíficos causantes de las hemorragias y complicaciones clínicas descritas en este tipo de patología. Estas cadenas de ácidos nucleicos están compuestas por la combinación especifica de fragmentos pertenecientes al gen de una proteína mutante con actividad deshidrogenasa de N.meningitidis y fragmentos que codifican para una región de la proteína E de la envoltura de los virus del Dengue, las cuales al insertarse en un vector de expresión, dan como resultado las proteínas quiméricas con características especificas. Las moléculas quiméricas resultantes de esta invención son aplicables a la industria farmacéutica en la obtención de preparados vacunales y diagnósticos de alta especificidad serotípica para uso en humanos.
PCT/CU2002/000006 2001-07-16 2002-07-12 Cadenas quiméricas codificantes para proteínas inductoras de efectos contra virus WO2003008571A2 (es)

Priority Applications (11)

Application Number Priority Date Filing Date Title
MXPA04000486A MXPA04000486A (es) 2001-07-16 2002-07-12 Cadenas quimericas codificantes para proteinas inductoras de efectos contra virus.
DE60217129T DE60217129T2 (de) 2001-07-16 2002-07-12 Chimärische nukleinsäuren kodierend für proteine, die effekte gegen viren induzieren
CA2453300A CA2453300C (en) 2001-07-16 2002-07-12 Chimeric chains that code for proteins that induce effects directed against viruses
DK02760073T DK1418180T3 (da) 2001-07-16 2002-07-12 Kimære kæder, der koder for proteiner, som inducerer virkninger mod virus
BR0211178-0A BR0211178A (pt) 2001-07-16 2002-07-12 Cadeias nucleotìdicas quiméricas, proteìnas quiméricas, preparação farmacêutica, e, método diagnóstico
EP02760073A EP1418180B1 (en) 2001-07-16 2002-07-12 Chimeric chains that code for proteins that induce effects directed against viruses
US10/484,114 US7279164B2 (en) 2001-07-16 2002-07-12 Chimeric proteins that induce effects directed against viruses
JP2003514888A JP4417712B2 (ja) 2001-07-16 2002-07-12 ウイルスに対する作用を誘導するタンパク質をコードするキメラ鎖
US11/705,696 US7566457B2 (en) 2001-07-16 2007-02-13 Chimeric proteins that induce effects directed against viruses
US12/483,607 US7947281B2 (en) 2001-07-16 2009-06-12 Chimeric proteins that induce effects directed against viruses
US13/094,287 US8105606B2 (en) 2001-07-16 2011-04-26 Chimeric proteins that induce effects directed against viruses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU20010172A CU23245A1 (es) 2001-07-16 2001-07-16 CADENAS QUIMéRICAS CODIFICANTES PARA PROTEINAS INDUCTORAS DE EFECTOS CONTRA VIRUS. PREPARADOS UTILIZANDO PROTEINAS QUIMéRICAS
CU2001-0172 2001-07-16

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10484114 A-371-Of-International 2002-07-12
US11/705,696 Division US7566457B2 (en) 2001-07-16 2007-02-13 Chimeric proteins that induce effects directed against viruses

Publications (3)

Publication Number Publication Date
WO2003008571A2 WO2003008571A2 (es) 2003-01-30
WO2003008571A3 true WO2003008571A3 (es) 2004-03-04
WO2003008571A9 WO2003008571A9 (es) 2004-04-15

Family

ID=40091633

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CU2002/000006 WO2003008571A2 (es) 2001-07-16 2002-07-12 Cadenas quiméricas codificantes para proteínas inductoras de efectos contra virus

Country Status (18)

Country Link
US (4) US7279164B2 (es)
EP (1) EP1418180B1 (es)
JP (1) JP4417712B2 (es)
KR (1) KR100991717B1 (es)
CN (1) CN100378123C (es)
AT (1) ATE349466T1 (es)
BR (1) BR0211178A (es)
CA (1) CA2453300C (es)
CU (1) CU23245A1 (es)
DE (1) DE60217129T2 (es)
DK (1) DK1418180T3 (es)
ES (1) ES2278041T3 (es)
GT (1) GT200200150A (es)
MX (1) MXPA04000486A (es)
MY (1) MY138482A (es)
PT (1) PT1418180E (es)
WO (1) WO2003008571A2 (es)
ZA (1) ZA200400289B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU23245A1 (es) 2001-07-16 2007-10-17 Inst De Medicina Tropical Pedr CADENAS QUIMéRICAS CODIFICANTES PARA PROTEINAS INDUCTORAS DE EFECTOS CONTRA VIRUS. PREPARADOS UTILIZANDO PROTEINAS QUIMéRICAS
CU23578A1 (es) * 2005-09-16 2010-09-30 Ct Ingenieria Genetica Biotech Proteína de la cápsida del virus dengue inductora de respuesta protectora y composición vacunal
CU23586A1 (es) 2005-11-22 2010-10-30 Ct Ingenieria Genetica Biotech Métodos y proteínas para el tratamiento profiláctico y/o terapéutico de los cuatro serotipos del virus de dengue y otros flavivirus
CU23630A1 (es) 2006-10-30 2011-02-24 Ct Ingenieria Genetica Biotech Moléculas peptídicas quiméricas con propiedades antivirales contra los virus de la familia flaviviridae
CU20080028A6 (es) * 2008-02-29 2011-02-24 Ct Ingenieria Genetica Biotech Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus
EP2632485A4 (en) * 2010-10-29 2014-05-28 Merck Sharp & Dohme RECOMBINANT SUBUNIT VACCINE AGAINST DENGUE VIRUS
CU24188B1 (es) * 2012-12-27 2016-07-29 Ct De Ingeniería Genética Y Biotecnología Composición vacunal contra el virus dengue
ITRM20130458A1 (it) * 2013-08-05 2015-02-05 Internat Ct For Genetic En Gineering And Vaccino genetico anti-dengue virus basato sugli ectodomini della proteina envelope
CN113429479B (zh) * 2018-04-04 2023-03-10 中国科学院微生物研究所 一种高灵敏度的黄热病毒人源单克隆抗体及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0474313A2 (en) * 1990-09-07 1992-03-11 Centro De Ingenieria Genetica Y Biotecnologia Nucleotide sequence coding for an outer membrane protein from Neisseria meningitidis and use of said protein in vaccine preparations
WO1996037221A1 (en) * 1995-05-24 1996-11-28 Hawaii Biotechnology Group, Inc. Subunit vaccine against flavivirus infection
WO1997026359A1 (es) * 1996-01-17 1997-07-24 Centro De Ingenieria Genetica Y Biotecnologia (Cigb) Sistema de expresion de antigenos heterologos como proteinas de fusion
WO2000066791A1 (en) * 1999-04-30 2000-11-09 Chiron Corporation Neisseria genomic sequences and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2153223T3 (es) 1991-09-19 2001-02-16 Us Health Flavivirus quimericos y/o flavivirus de crecimiento restringido.
WO1997043310A1 (en) 1996-05-10 1997-11-20 Schering Corporation Synthetic inhibitors of hepatitis c virus ns3 protease
CU22666A1 (es) 1996-11-25 2001-04-27 Inst De Medicina Tropical Pedro Kouri Procedimiento para la expresión de genes de los virus del dengue en la levadura pichia pastoris, adns recombinantes y microorganismos transformados
CU22683A1 (es) * 1997-01-15 2001-07-20 Inst De Medicina Tropical Pedro Kouri Epítopes de la proteína pre-m/m del virus del dengue, péptidos sintéticos, proteínas quiméricas y sus usos
ES2241157T3 (es) 1997-08-11 2005-10-16 Boehringer Ingelheim (Canada) Ltd. Peptidos inhibidores de la hepatitis c.
DE69833002T2 (de) 1997-10-08 2006-08-24 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Chimärer impfstoff gegen das zeckenenzephalitis virus
CU23245A1 (es) 2001-07-16 2007-10-17 Inst De Medicina Tropical Pedr CADENAS QUIMéRICAS CODIFICANTES PARA PROTEINAS INDUCTORAS DE EFECTOS CONTRA VIRUS. PREPARADOS UTILIZANDO PROTEINAS QUIMéRICAS
AU2003239932A1 (en) * 2002-05-31 2003-12-19 Acambis, Inc. Tetravalent dengue vaccines
WO2004052293A2 (en) 2002-12-11 2004-06-24 Hawaii Biotech, Inc. Recombinant vaccine against flavivirus infection
EP1454988A1 (en) 2003-03-03 2004-09-08 Institut National De La Sante Et De La Recherche Medicale (Inserm) Infectious flavivirus pseudo-particles containing functional prM-E envelope proteins
WO2005002501A2 (en) 2003-04-22 2005-01-13 Children's Medical Center Corporation Novel druggable regions in the dengue virus envelope glycoprotein and methods of using the same
MY157941A (en) 2005-01-19 2016-08-15 Vaxinnate Corp Compositions of pathogen-associated molecular patterns and methods of use
CA2508266A1 (fr) 2005-06-20 2006-12-20 Institut Pasteur Polypeptides chimeriques et leurs applications therapeutiques contre une infection a flaviviridae
CU23632A1 (es) 2006-04-28 2011-02-24 Ct Ingenieria Genetica Biotech Métodos para la identificación de candidatos terapéuticos contra enfermedades causadas por flavivirus y moléculas antivirales.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0474313A2 (en) * 1990-09-07 1992-03-11 Centro De Ingenieria Genetica Y Biotecnologia Nucleotide sequence coding for an outer membrane protein from Neisseria meningitidis and use of said protein in vaccine preparations
WO1996037221A1 (en) * 1995-05-24 1996-11-28 Hawaii Biotechnology Group, Inc. Subunit vaccine against flavivirus infection
WO1997026359A1 (es) * 1996-01-17 1997-07-24 Centro De Ingenieria Genetica Y Biotecnologia (Cigb) Sistema de expresion de antigenos heterologos como proteinas de fusion
WO2000066791A1 (en) * 1999-04-30 2000-11-09 Chiron Corporation Neisseria genomic sequences and methods of their use

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BLOK J ET AL: "VARIATION OF THE NUCLEOTIDE AND ENCODED AMINO ACID SEQUENCES OF THE ENVELOPE GENE FROM EIGHT DENGUE-2 VIRUSES", ARCHIVES OF VIROLOGY, vol. 105, no. 1-2, 1989, pages 39 - 53, XP002230298, ISSN: 0304-8608 *
LANCIOTTI ROBERT S ET AL: "Molecular evolution and epidemiology of dengue-3 viruses.", JOURNAL OF GENERAL VIROLOGY, vol. 75, no. 1, 1994, pages 65 - 75, XP002230297, ISSN: 0022-1317 *
LANCIOTTI ROBERT S ET AL: "Molecular evolution and phylogeny of dengue-4 viruses.", JOURNAL OF GENERAL VIROLOGY, vol. 78, no. 9, 1997, pages 2279 - 2286, XP002230296, ISSN: 0022-1317 *
SILVA RICARDO ET AL: "Characterisation of the lpdA gene from Neisseria meningitidis by polymerase chain reaction, restriction fragment length polymorphism and sequencing.", FEMS MICROBIOLOGY LETTERS, vol. 174, no. 1, 1 May 1999 (1999-05-01), pages 191 - 199, XP002230295, ISSN: 0378-1097 *
TETTELIN HERVE ET AL: "Complete genome sequence of Neisseria meningitidis serogroup B strain MC58.", SCIENCE (WASHINGTON D C), vol. 287, no. 5459, 10 March 2000 (2000-03-10), pages 1809 - 1815, XP002230293, ISSN: 0036-8075 *
WANG ERYU ET AL: "Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses.", JOURNAL OF VIROLOGY, vol. 74, no. 7, April 2000 (2000-04-01), pages 3227 - 3234, XP002230294, ISSN: 0022-538X *

Also Published As

Publication number Publication date
US8105606B2 (en) 2012-01-31
US7566457B2 (en) 2009-07-28
US20070141081A1 (en) 2007-06-21
PT1418180E (pt) 2007-04-30
US20110200628A1 (en) 2011-08-18
ZA200400289B (en) 2004-09-12
EP1418180B1 (en) 2006-12-27
ES2278041T3 (es) 2007-08-01
US20040234951A1 (en) 2004-11-25
KR100991717B1 (ko) 2010-11-03
US7279164B2 (en) 2007-10-09
CU23245A1 (es) 2007-10-17
US20090274718A1 (en) 2009-11-05
DE60217129D1 (de) 2007-02-08
ATE349466T1 (de) 2007-01-15
CA2453300C (en) 2012-03-20
MY138482A (en) 2009-06-30
CN1531548A (zh) 2004-09-22
JP2004537306A (ja) 2004-12-16
GT200200150A (es) 2003-06-19
EP1418180A2 (en) 2004-05-12
WO2003008571A9 (es) 2004-04-15
MXPA04000486A (es) 2005-03-07
DK1418180T3 (da) 2007-05-07
CN100378123C (zh) 2008-04-02
DE60217129T2 (de) 2007-10-31
CA2453300A1 (en) 2003-01-30
US7947281B2 (en) 2011-05-24
BR0211178A (pt) 2004-08-10
WO2003008571A2 (es) 2003-01-30
JP4417712B2 (ja) 2010-02-17
KR20040030056A (ko) 2004-04-08

Similar Documents

Publication Publication Date Title
WO2005005610A3 (en) Mutant adeno-associated virus virions and methods of use thereof
WO2003048184A3 (en) Flavivirus ns1 subunit vaccine
BRPI0309631A8 (pt) vacina tetravalente da dengue contendo uma trivial deleção de 30 nucleotídeos na utr-31' dos tipos de dengue 1,2,3 e 4, ou de vírus antigênicos quiméricos da dengue 1,2,3 e 4
WO2006044923A3 (en) Yeast-based therapeutic for chronic hepatitis c infection
WO2002061113A3 (en) Nucleic acid derived vaccine that encodes an antigen linked to a polypeptide that promotes antigen presentation
JP2004511201A5 (es)
WO2000066739A3 (en) Chlamydia antigens and corresponding dna fragments and uses thereof
EP2351843A3 (en) Rabies virus vector systems and compositions and methods thereof
WO2004096842A3 (en) Sars virus nucleotide and amino acid sequences and uses thereof
WO2006136448A3 (en) Attenuated sars and use as a vaccine
WO2004085633A8 (en) A novel human virus causing severe acute respiratory syndrome (sars) and uses thereof
WO2003008571A3 (es) Cadenas quiméricas codificantes para proteínas inductoras de efectos contra virus
DE69732029D1 (de) Dna enthaltende impfstoffen
Xue et al. Molecular engineering tools for the development of vaccines against infectious diseases: current status and future directions
BR9815285A (pt) Vetores alfavìrus para vacina de paramixovìrus
WO2005033265A3 (en) Optimized multi-epitope constructs and uses thereof
ATE417106T1 (de) Chlamydia antigene und deren korrespondierende dna fragmente und verwendungen davon
WO2009101604A3 (en) Recombinant lumpy skin disease virus for preventing aids
CA2198743A1 (en) Feline infectious peritonitis vaccine
WO2005016247A3 (en) Dna sequences, peptides, antibodies and vaccines for prevention and treatment of sars
AU2018200081B2 (en) Avirulent, immunogenic flavivirus chimeras
DE60128950D1 (de) Proteine aus yaba monkey tumor virus mit modulatorischer aktivität
WO2002044366A3 (en) Retina-specific human proteins c70rf9, c120rf7, mpp4 and f379
WO2005001096A8 (fr) Vaccins contre le sras
EP0789563B8 (en) Hepatitis virus b and c vaccines

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2453300

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2004/00289

Country of ref document: ZA

Ref document number: 200400289

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: 1020047000610

Country of ref document: KR

Ref document number: 2003514888

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: PA/a/2004/000486

Country of ref document: MX

Ref document number: 20028143507

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 289/DELNP/2004

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2002760073

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2002325784

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 1020047000610

Country of ref document: KR

COP Corrected version of pamphlet

Free format text: INDICATIONS IN RELATION TO DEPOSITED BIOLOGICAL MATERIALS, ADDED 24 PAGES (WITH AN UPDATED VERSION OF THE PAMPHLET FRONT PAGE)

WWP Wipo information: published in national office

Ref document number: 2002760073

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10484114

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 1-2004-500057

Country of ref document: PH

WWG Wipo information: grant in national office

Ref document number: 2002760073

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 2002325784

Country of ref document: AU