WO2002081694A1 - Procede de secretion et de production de proteine - Google Patents

Procede de secretion et de production de proteine Download PDF

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Publication number
WO2002081694A1
WO2002081694A1 PCT/JP2002/002978 JP0202978W WO02081694A1 WO 2002081694 A1 WO2002081694 A1 WO 2002081694A1 JP 0202978 W JP0202978 W JP 0202978W WO 02081694 A1 WO02081694 A1 WO 02081694A1
Authority
WO
WIPO (PCT)
Prior art keywords
foreign protein
coryneform bacterium
produce
protein
sectetion
Prior art date
Application number
PCT/JP2002/002978
Other languages
English (en)
French (fr)
Other versions
WO2002081694A8 (fr
Inventor
Yoshimi Kikuchi
Masayo Date
Yukiko Umezawa
Keiichi Yokoyama
Haruo Heima
Hiroshi Matsui
Original Assignee
Ajinomoto Co.,Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP02708684A priority Critical patent/EP1375664B1/en
Priority to BRPI0208136-9A priority patent/BR0208136B1/pt
Priority to CA2442679A priority patent/CA2442679C/en
Priority to AT02708684T priority patent/ATE447615T1/de
Priority to DK02708684.2T priority patent/DK1375664T3/da
Priority to DE60234247T priority patent/DE60234247D1/de
Application filed by Ajinomoto Co.,Inc. filed Critical Ajinomoto Co.,Inc.
Priority to KR1020037012833A priority patent/KR100602807B1/ko
Priority to JP2002580057A priority patent/JP4362651B2/ja
Priority to AU2002242986A priority patent/AU2002242986A1/en
Publication of WO2002081694A1 publication Critical patent/WO2002081694A1/ja
Publication of WO2002081694A8 publication Critical patent/WO2002081694A8/ja
Priority to US10/673,860 priority patent/US7252972B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
PCT/JP2002/002978 2001-03-30 2002-03-27 Procede de secretion et de production de proteine WO2002081694A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BRPI0208136-9A BR0208136B1 (pt) 2001-03-30 2002-03-27 Método para produzir uma proteína heteróloga
CA2442679A CA2442679C (en) 2001-03-30 2002-03-27 Methods for secretory production of proteins
AT02708684T ATE447615T1 (de) 2001-03-30 2002-03-27 Verfahren zur sekretion und produktion von protein
DK02708684.2T DK1375664T3 (da) 2001-03-30 2002-03-27 Fremgangsmåde til udskillelsen og fremstilling af protein
DE60234247T DE60234247D1 (de) 2001-03-30 2002-03-27 Verfahren zur sekretion und produktion von protein
EP02708684A EP1375664B1 (en) 2001-03-30 2002-03-27 Method for the secretion and production of protein
KR1020037012833A KR100602807B1 (ko) 2001-03-30 2002-03-27 단백질의 분비 생산 방법
JP2002580057A JP4362651B2 (ja) 2001-03-30 2002-03-27 タンパク質の分泌生産法
AU2002242986A AU2002242986A1 (en) 2001-03-30 2002-03-27 Method for the sectetion and production of protein
US10/673,860 US7252972B2 (en) 2001-03-30 2003-09-30 Methods for secretory production of proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-98808 2001-03-30
JP2001098808 2001-03-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/673,860 Continuation US7252972B2 (en) 2001-03-30 2003-09-30 Methods for secretory production of proteins

Publications (2)

Publication Number Publication Date
WO2002081694A1 true WO2002081694A1 (fr) 2002-10-17
WO2002081694A8 WO2002081694A8 (fr) 2002-11-14

Family

ID=18952423

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/002978 WO2002081694A1 (fr) 2001-03-30 2002-03-27 Procede de secretion et de production de proteine

Country Status (14)

Country Link
US (1) US7252972B2 (ja)
EP (1) EP1375664B1 (ja)
JP (1) JP4362651B2 (ja)
KR (1) KR100602807B1 (ja)
CN (1) CN1250722C (ja)
AT (1) ATE447615T1 (ja)
AU (1) AU2002242986A1 (ja)
BR (1) BR0208136B1 (ja)
CA (1) CA2442679C (ja)
DE (1) DE60234247D1 (ja)
DK (1) DK1375664T3 (ja)
ES (1) ES2335750T3 (ja)
RU (1) RU2264463C2 (ja)
WO (1) WO2002081694A1 (ja)

Cited By (25)

* Cited by examiner, † Cited by third party
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WO2005103278A1 (ja) * 2004-04-20 2005-11-03 Ajinomoto Co., Inc. タンパク質の製造法
JP2008502354A (ja) * 2004-06-14 2008-01-31 ノボザイムス アクティーゼルスカブ ポリペプチド製造用シグナルペプチド
WO2008099898A1 (ja) 2007-02-15 2008-08-21 Ajinomoto Co., Inc. ジスルフィド結合導入トランスグルタミナーゼ
JP2008212155A (ja) * 2003-12-18 2008-09-18 Basf Se Ｐｅｆ−ｔｕ発現ユニット
JP2008212156A (ja) * 2004-07-20 2008-09-18 Basf Se Ｐｅｆ−ｔｓ発現ユニット
WO2008120798A1 (ja) 2007-03-29 2008-10-09 Ajinomoto Co., Inc. 接着用酵素製剤及び接着成形食品の製造方法
WO2009066785A1 (ja) 2007-11-19 2009-05-28 Ajinomoto Co., Inc. 繊維加工物及びその製造法
WO2010035856A1 (ja) 2008-09-25 2010-04-01 味の素株式会社 接着成形食品用酵素製剤及び接着成形食品の製造方法
WO2010101256A1 (ja) 2009-03-06 2010-09-10 味の素株式会社 放線菌由来の耐熱性トランスグルタミナーゼ
WO2011105344A1 (ja) 2010-02-23 2011-09-01 東レ株式会社 カダベリンの製造方法
US8124379B2 (en) 2004-06-14 2012-02-28 Novozymes A/S Signal peptide for producing a polypeptide
WO2013062029A1 (ja) * 2011-10-25 2013-05-02 味の素株式会社 タンパク質の分泌生産法
WO2017082374A1 (ja) 2015-11-12 2017-05-18 味の素株式会社 Ｎε－アシル－Ｌ－リジンの製造方法
WO2017191817A1 (ja) 2016-05-02 2017-11-09 味の素株式会社 アジド基含有Ｆｃタンパク質
WO2018074579A1 (ja) 2016-10-21 2018-04-26 味の素株式会社 タンパク質の分泌生産法
WO2018074578A1 (ja) 2016-10-21 2018-04-26 味の素株式会社 タンパク質の分泌生産法
WO2018135027A1 (ja) 2017-01-19 2018-07-26 味の素株式会社 ヘキスロン酸残基が異性化されたヘパロサン化合物の製造方法
WO2019050051A1 (en) 2017-09-05 2019-03-14 Ajinomoto Co., Inc. MUTANT OF 2-O-SULFATION ENZYME AND MUTANT OF 3-O-SULFATION ENZYME, AND METHOD OF USE
JP2019526283A (ja) * 2016-09-01 2019-09-19 ニンシア エッペン バイオテック カンパニー リミテッド Ｌ−リジンを発酵生産するコリネバクテリウム菌
WO2019203368A1 (ja) 2018-04-20 2019-10-24 味の素株式会社 タンパク質の分泌生産法
WO2020085511A1 (ja) 2018-10-25 2020-04-30 味の素株式会社 タンパク質の分泌生産法
WO2020090979A1 (ja) 2018-10-31 2020-05-07 味の素株式会社 抗体に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩
WO2021177392A1 (ja) 2020-03-04 2021-09-10 味の素株式会社 変異型トランスグルタミナーゼ
WO2022071061A1 (ja) 2020-09-29 2022-04-07 味の素株式会社 変異型トランスグルタミナーゼ
WO2023282315A1 (ja) 2021-07-07 2023-01-12 味の素株式会社 非天然アミノ酸含有タンパク質の分泌生産法

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ES2313878T3 (es) 2000-01-21 2009-03-16 Ajinomoto Co., Inc. Procedimiento para la produccion de l-lisina.
KR20050106502A (ko) * 2003-03-07 2005-11-09 아지노모토 가부시키가이샤 미생물 트랜스글루타미나제의 제조방법
DE10359660A1 (de) * 2003-12-18 2005-07-28 Basf Ag Psod-Expressionseinheiten
KR100620092B1 (ko) * 2004-12-16 2006-09-08 씨제이 주식회사 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법
EP1902126A1 (en) * 2005-07-12 2008-03-26 Codon Devices, Inc Compositions and methods for biocatalytic engineering
RU2338784C2 (ru) * 2006-03-24 2008-11-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Новая альдолаза, днк, кодирующая альдолазу, клетки, трансформированные днк, способ получения альдолазы и способ получения 4-гидрокси-l-изолейцина (варианты)
ES2539280T3 (es) * 2006-10-24 2015-06-29 Basf Se Procedimiento de reducción de la expresión génica mediante el uso de codones modificado
JP5445453B2 (ja) * 2008-07-09 2014-03-19 味の素株式会社 アミノヒドロキシ安息香酸類の製造方法
AU2012333515B2 (en) 2011-11-02 2015-07-16 Ajinomoto Co., Inc. Method for secreting and producing proteins
IN2014CN04039A (ja) 2011-11-02 2015-10-23 Ajinomoto Kk
MX2014011459A (es) 2012-03-26 2015-02-04 Pronutria Inc Proteinas nutritivas cargadas y metodos.
US9700071B2 (en) 2012-03-26 2017-07-11 Axcella Health Inc. Nutritive fragments, proteins and methods
SG10201604458VA (en) 2012-03-26 2016-07-28 Axcella Health Inc Nutritive fragments, proteins and methods
WO2013148328A1 (en) 2012-03-26 2013-10-03 Pronutria, Inc. Nutritive proteins and methods
JP2016537402A (ja) 2013-09-25 2016-12-01 アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． 癌の処置における、腫瘍形成、癌細胞の増殖および浸潤の予防および低減のための組成物および配合物、ならびにその生成方法および使用方法
EP3287523B1 (en) 2015-04-24 2022-06-29 Ajinomoto Co., Inc. Method for secretory production of protein
EP3415622A1 (en) 2017-06-14 2018-12-19 Evonik Degussa GmbH Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases

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WO1993003158A1 (fr) * 1991-07-30 1993-02-18 Orsan Systeme d'expression et de secretion de proteines utilisables en particulier chez les corynebacteries
JPH11169182A (ja) * 1997-12-10 1999-06-29 Mitsubishi Chemical Corp コリネ型細菌内で蛋白質を効率よく培地中へ分泌させる変異型分泌装置遺伝子
WO2001023591A1 (fr) * 1999-09-30 2001-04-05 Ajinomoto Co., Inc. Procédé de production de transglutaminase

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Publication number Priority date Publication date Assignee Title
JP2008212155A (ja) * 2003-12-18 2008-09-18 Basf Se Ｐｅｆ−ｔｕ発現ユニット
JP4730302B2 (ja) * 2004-04-20 2011-07-20 味の素株式会社 タンパク質の製造法
US8597907B2 (en) 2004-04-20 2013-12-03 Ajinomoto Co., Inc. Method of producing proteins
JPWO2005103278A1 (ja) * 2004-04-20 2008-03-13 味の素株式会社 タンパク質の製造法
WO2005103278A1 (ja) * 2004-04-20 2005-11-03 Ajinomoto Co., Inc. タンパク質の製造法
JP4809347B2 (ja) * 2004-06-14 2011-11-09 ノボザイムス アクティーゼルスカブ ポリペプチド製造用シグナルペプチド
JP2008502354A (ja) * 2004-06-14 2008-01-31 ノボザイムス アクティーゼルスカブ ポリペプチド製造用シグナルペプチド
US8124379B2 (en) 2004-06-14 2012-02-28 Novozymes A/S Signal peptide for producing a polypeptide
CN1969041B (zh) * 2004-06-14 2012-06-20 诺维信公司 用于生产多肽的信号肽
JP2008212156A (ja) * 2004-07-20 2008-09-18 Basf Se Ｐｅｆ−ｔｓ発現ユニット
US8735159B2 (en) 2004-07-20 2014-05-27 Basf Se PEF-TS expression units
WO2008099898A1 (ja) 2007-02-15 2008-08-21 Ajinomoto Co., Inc. ジスルフィド結合導入トランスグルタミナーゼ
WO2008120798A1 (ja) 2007-03-29 2008-10-09 Ajinomoto Co., Inc. 接着用酵素製剤及び接着成形食品の製造方法
WO2009066785A1 (ja) 2007-11-19 2009-05-28 Ajinomoto Co., Inc. 繊維加工物及びその製造法
WO2010035856A1 (ja) 2008-09-25 2010-04-01 味の素株式会社 接着成形食品用酵素製剤及び接着成形食品の製造方法
WO2010101256A1 (ja) 2009-03-06 2010-09-10 味の素株式会社 放線菌由来の耐熱性トランスグルタミナーゼ
US8871477B2 (en) 2010-02-23 2014-10-28 Toray Industries, Inc. Process for production of cadaverine
WO2011105344A1 (ja) 2010-02-23 2011-09-01 東レ株式会社 カダベリンの製造方法
US9376701B2 (en) 2011-10-25 2016-06-28 Ajinomoto Co., Inc. Method for secretory production of protein
WO2013062029A1 (ja) * 2011-10-25 2013-05-02 味の素株式会社 タンパク質の分泌生産法
WO2017082374A1 (ja) 2015-11-12 2017-05-18 味の素株式会社 Ｎε－アシル－Ｌ－リジンの製造方法
WO2017191817A1 (ja) 2016-05-02 2017-11-09 味の素株式会社 アジド基含有Ｆｃタンパク質
US11149074B2 (en) 2016-05-02 2021-10-19 Ajinomoto Co., Inc. Azide group-containing Fc protein
JP2019526283A (ja) * 2016-09-01 2019-09-19 ニンシア エッペン バイオテック カンパニー リミテッド Ｌ−リジンを発酵生産するコリネバクテリウム菌
US11242545B2 (en) 2016-09-01 2022-02-08 Ningxia Eppen Biotech Co., Ltd Corynebacterium for producing L-lysine by fermentation
WO2018074579A1 (ja) 2016-10-21 2018-04-26 味の素株式会社 タンパク質の分泌生産法
CN110312807A (zh) * 2016-10-21 2019-10-08 味之素株式会社 蛋白质的分泌产生方法
WO2018074578A1 (ja) 2016-10-21 2018-04-26 味の素株式会社 タンパク質の分泌生産法
CN110312807B (zh) * 2016-10-21 2023-11-17 味之素株式会社 蛋白质的分泌产生方法
WO2018135027A1 (ja) 2017-01-19 2018-07-26 味の素株式会社 ヘキスロン酸残基が異性化されたヘパロサン化合物の製造方法
WO2019050051A1 (en) 2017-09-05 2019-03-14 Ajinomoto Co., Inc. MUTANT OF 2-O-SULFATION ENZYME AND MUTANT OF 3-O-SULFATION ENZYME, AND METHOD OF USE
EP4050036A1 (en) 2017-09-05 2022-08-31 Ajinomoto Co., Inc. 3-o-sulfation enzyme mutant, and method for using same
WO2019203368A1 (ja) 2018-04-20 2019-10-24 味の素株式会社 タンパク質の分泌生産法
WO2020085511A1 (ja) 2018-10-25 2020-04-30 味の素株式会社 タンパク質の分泌生産法
WO2020090979A1 (ja) 2018-10-31 2020-05-07 味の素株式会社 抗体に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩
WO2021177392A1 (ja) 2020-03-04 2021-09-10 味の素株式会社 変異型トランスグルタミナーゼ
WO2022071061A1 (ja) 2020-09-29 2022-04-07 味の素株式会社 変異型トランスグルタミナーゼ
WO2023282315A1 (ja) 2021-07-07 2023-01-12 味の素株式会社 非天然アミノ酸含有タンパク質の分泌生産法

Also Published As

Publication number Publication date
ES2335750T3 (es) 2010-04-05
CA2442679C (en) 2010-06-01
JP4362651B2 (ja) 2009-11-11
EP1375664B1 (en) 2009-11-04
AU2002242986A1 (en) 2002-10-21
EP1375664A1 (en) 2004-01-02
DE60234247D1 (de) 2009-12-17
WO2002081694A8 (fr) 2002-11-14
CN1250722C (zh) 2006-04-12
EP1375664A4 (en) 2005-08-17
CN1500145A (zh) 2004-05-26
RU2264463C2 (ru) 2005-11-20
KR100602807B1 (ko) 2006-07-20
BR0208136B1 (pt) 2014-10-21
US7252972B2 (en) 2007-08-07
KR20030087042A (ko) 2003-11-12
JPWO2002081694A1 (ja) 2004-07-29
US20040126847A1 (en) 2004-07-01
BR0208136A (pt) 2004-03-02
CA2442679A1 (en) 2002-10-17
DK1375664T3 (da) 2010-02-08
ATE447615T1 (de) 2009-11-15
RU2003128977A (ru) 2005-02-27

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