WO2002059106A1 - Isoindole-imide compounds, compositions, and uses thereof - Google Patents

Isoindole-imide compounds, compositions, and uses thereof Download PDF

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Publication number
WO2002059106A1
WO2002059106A1 PCT/US2001/050401 US0150401W WO02059106A1 WO 2002059106 A1 WO2002059106 A1 WO 2002059106A1 US 0150401 W US0150401 W US 0150401W WO 02059106 A1 WO02059106 A1 WO 02059106A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
dioxo
piperidyl
methyl
piperidin
Prior art date
Application number
PCT/US2001/050401
Other languages
English (en)
French (fr)
Inventor
Michael J. Robarge
Roger Shen-Chu Chen
George W. Muller
Hon-Wah Man
Original Assignee
Celgene Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK01997133T priority Critical patent/DK1363900T3/da
Priority to JP2002559408A priority patent/JP4284071B2/ja
Application filed by Celgene Corporation filed Critical Celgene Corporation
Priority to AU2002248252A priority patent/AU2002248252B2/en
Priority to EP01997133A priority patent/EP1363900B1/en
Priority to IL15664601A priority patent/IL156646A0/xx
Priority to KR1020037008812A priority patent/KR100747436B1/ko
Priority to NZ526893A priority patent/NZ526893A/en
Priority to DE60126344T priority patent/DE60126344T2/de
Priority to CA2433021A priority patent/CA2433021C/en
Priority to HU0302578A priority patent/HU229003B1/hu
Priority to KR1020077018941A priority patent/KR100889116B1/ko
Priority to MXPA03005786A priority patent/MXPA03005786A/es
Publication of WO2002059106A1 publication Critical patent/WO2002059106A1/en
Priority to IL156646A priority patent/IL156646A/en
Priority to ZA2003/05759A priority patent/ZA200305759B/en
Priority to HK04102764A priority patent/HK1061396A1/xx
Priority to AU2006200717A priority patent/AU2006200717B8/en
Priority to CY20071100444T priority patent/CY1106423T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A—HUMAN NECESSITIES
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    • A61P37/02—Immunomodulators
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
PCT/US2001/050401 2000-12-27 2001-12-21 Isoindole-imide compounds, compositions, and uses thereof WO2002059106A1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CA2433021A CA2433021C (en) 2000-12-27 2001-12-21 Isoindole-imide compounds, compositions, and uses thereof
DE60126344T DE60126344T2 (de) 2000-12-27 2001-12-21 Isoindolimid-verbindungen, zusammensetzungen und verwendungen
AU2002248252A AU2002248252B2 (en) 2000-12-27 2001-12-21 Isoindole-imide compounds, compositions, and uses thereof
EP01997133A EP1363900B1 (en) 2000-12-27 2001-12-21 Isoindole-imide compounds, compositions and uses thereof
IL15664601A IL156646A0 (en) 2000-12-27 2001-12-21 Isoindole-imide compounds, compositions, and uses thereof
KR1020037008812A KR100747436B1 (ko) 2000-12-27 2001-12-21 이소인돌-이미드 화합물
NZ526893A NZ526893A (en) 2000-12-27 2001-12-21 Isoindole-imide compounds, compositions, and uses thereof
DK01997133T DK1363900T3 (da) 2000-12-27 2001-12-21 Isoindol-imid-forbindelser, præparater og anvendelser deraf
JP2002559408A JP4284071B2 (ja) 2000-12-27 2001-12-21 イソインドール−イミド化合物、組成物、およびそれらの使用
KR1020077018941A KR100889116B1 (ko) 2000-12-27 2001-12-21 이소인돌-이미드 화합물
HU0302578A HU229003B1 (hu) 2000-12-27 2001-12-21 Izoindol-imid típusú vegyületek, az ezeket tartalmazó készítmények és eljárás ezek alkalmazására
MXPA03005786A MXPA03005786A (es) 2000-12-27 2001-12-21 Compuestos de isoindol-imida, composiciones que los contienen, y usos de los mismos.
IL156646A IL156646A (en) 2000-12-27 2003-06-25 Isoindole-amide compounds, medicinal preparations containing them and their use in the preparation of medicines
ZA2003/05759A ZA200305759B (en) 2000-12-27 2003-07-25 Isoindole-imide compounds compositions and uses thereof
HK04102764A HK1061396A1 (en) 2000-12-27 2004-04-20 Isoindole-imide compounds, compositions and uses thereof
AU2006200717A AU2006200717B8 (en) 2000-12-27 2006-02-21 Isoindole-imide compounds, compositions, and uses thereof
CY20071100444T CY1106423T1 (el) 2000-12-27 2007-03-29 Ενωσεις ισοϊνδολο-ιμιδιου, συνθεσεις και χρησεις αυτων

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25837200P 2000-12-27 2000-12-27
US60/258,372 2000-12-27
US09/972,487 US20030045552A1 (en) 2000-12-27 2001-10-05 Isoindole-imide compounds, compositions, and uses thereof
US09/972,487 2001-10-05

Publications (1)

Publication Number Publication Date
WO2002059106A1 true WO2002059106A1 (en) 2002-08-01

Family

ID=26946597

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/050401 WO2002059106A1 (en) 2000-12-27 2001-12-21 Isoindole-imide compounds, compositions, and uses thereof

Country Status (20)

Country Link
US (1) US20030045552A1 (US20030045552A1-20030306-C00236.png)
EP (3) EP1363900B1 (US20030045552A1-20030306-C00236.png)
JP (3) JP4284071B2 (US20030045552A1-20030306-C00236.png)
KR (4) KR20070026879A (US20030045552A1-20030306-C00236.png)
AT (1) ATE352548T1 (US20030045552A1-20030306-C00236.png)
AU (3) AU2002248252B2 (US20030045552A1-20030306-C00236.png)
CA (1) CA2433021C (US20030045552A1-20030306-C00236.png)
CY (1) CY1106423T1 (US20030045552A1-20030306-C00236.png)
CZ (1) CZ20032041A3 (US20030045552A1-20030306-C00236.png)
DE (1) DE60126344T2 (US20030045552A1-20030306-C00236.png)
DK (1) DK1363900T3 (US20030045552A1-20030306-C00236.png)
ES (1) ES2275758T3 (US20030045552A1-20030306-C00236.png)
HK (1) HK1061396A1 (US20030045552A1-20030306-C00236.png)
HU (1) HU229003B1 (US20030045552A1-20030306-C00236.png)
IL (2) IL156646A0 (US20030045552A1-20030306-C00236.png)
MX (1) MXPA03005786A (US20030045552A1-20030306-C00236.png)
NZ (1) NZ526893A (US20030045552A1-20030306-C00236.png)
PT (1) PT1363900E (US20030045552A1-20030306-C00236.png)
WO (1) WO2002059106A1 (US20030045552A1-20030306-C00236.png)
ZA (1) ZA200305759B (US20030045552A1-20030306-C00236.png)

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JP2004538322A (ja) * 2001-08-06 2004-12-24 ザ チルドレンズ メディカル センター コーポレイション 窒素置換サリドマイド誘導体の合成及び抗腫瘍活性
EP1505973A2 (en) * 2002-05-17 2005-02-16 Celgene Corporation Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases
EP1567157A1 (en) * 2002-11-06 2005-08-31 Celgene Corporation Methods of using and compositions comprising immunomudulatory compounds for the treatment and management of myeloproliferative diseases
EP1567158A2 (en) * 2002-11-06 2005-08-31 Celgene Corporation Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases
JP2005336157A (ja) * 2004-04-30 2005-12-08 Arigen Inc 光学活性サリドマイドおよびその誘導体の製造法
EP1689223A2 (en) * 2003-11-06 2006-08-16 Celgene Corporation Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
US7119106B2 (en) 1996-07-24 2006-10-10 Celgene Corporation Pharmaceutical compositions of 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
WO2007005972A1 (en) * 2005-06-30 2007-01-11 Celgene Corporation Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds
EP1746995A1 (en) * 2004-05-05 2007-01-31 Celgene Corporation Method of using and compositions comprising immunomodulatory compounds for the treatment and management of myeloproliferative diseases
US7176222B2 (en) 2004-07-27 2007-02-13 Cytokinetics, Inc. Syntheses of ureas
WO2007028047A2 (en) 2005-09-01 2007-03-08 Celgene Corporation Immunological uses of immunodulatory compounds for vaccine and anti-infections disease therapy
US7189740B2 (en) 2002-10-15 2007-03-13 Celgene Corporation Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
WO2007033112A1 (en) 2005-09-12 2007-03-22 Celgene Corporation Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
WO2007027527A3 (en) * 2005-08-31 2007-05-24 Celgene Corp Isoindole-imide compounds and compositions comprising and methods of using the same
CN1326522C (zh) * 2002-10-24 2007-07-18 细胞基因公司 用于治疗、改变和控制疼痛的包含免疫调节化合物的组合物
WO2007136640A2 (en) * 2006-05-16 2007-11-29 Celgene Corporation Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
WO2007139464A1 (en) * 2006-05-26 2007-12-06 Astrazeneca Ab Isoindole derivatives useful for treating pain, gastrointestinal diseases and cancer
US7323479B2 (en) 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
US7329761B2 (en) 1994-12-30 2008-02-12 Celgene Corporation Substituted imides
EP1900369A1 (en) 2002-10-15 2008-03-19 Celgene Corporation Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes
WO2008033567A1 (en) * 2006-09-15 2008-03-20 Celgene Corporation N-methylaminomethyl isoindole compounds and compositions comprising and methods of using the same
AU2006202316B2 (en) * 2002-05-17 2008-04-10 Celgene Corporation Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases
US20080145368A1 (en) * 2002-05-17 2008-06-19 Celgene Corporation Methods using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
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