WO2002059106A1 - Isoindole-imide compounds, compositions, and uses thereof - Google Patents
Isoindole-imide compounds, compositions, and uses thereof Download PDFInfo
- Publication number
- WO2002059106A1 WO2002059106A1 PCT/US2001/050401 US0150401W WO02059106A1 WO 2002059106 A1 WO2002059106 A1 WO 2002059106A1 US 0150401 W US0150401 W US 0150401W WO 02059106 A1 WO02059106 A1 WO 02059106A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- dioxo
- piperidyl
- methyl
- piperidin
- Prior art date
Links
- 0 CCCCCCC(*Cc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O Chemical compound CCCCCCC(*Cc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O 0.000 description 9
- RITVZGDFSKPJIU-UHFFFAOYSA-N Cc1ccc(CNc(cccc2C(N3C(CCC(N4)=O)C4=O)=O)c2C3=O)[o]1 Chemical compound Cc1ccc(CNc(cccc2C(N3C(CCC(N4)=O)C4=O)=O)c2C3=O)[o]1 RITVZGDFSKPJIU-UHFFFAOYSA-N 0.000 description 2
- HADVZQNRDFIJQJ-UHFFFAOYSA-N O=C(CCCCCNC(OCc1ccccc1)=O)Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O Chemical compound O=C(CCCCCNC(OCc1ccccc1)=O)Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O HADVZQNRDFIJQJ-UHFFFAOYSA-N 0.000 description 2
- KHGZQRYXGMHVJJ-UHFFFAOYSA-N CC(C)NC(NCc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O Chemical compound CC(C)NC(NCc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O KHGZQRYXGMHVJJ-UHFFFAOYSA-N 0.000 description 1
- KBFZWSXWHKXWFA-UHFFFAOYSA-N CC(CC=C1)(C(C(N2C(CCC(N3)=O)C3=O)=O)=C1NC(CC(OC)=O)=O)C2=O Chemical compound CC(CC=C1)(C(C(N2C(CCC(N3)=O)C3=O)=O)=C1NC(CC(OC)=O)=O)C2=O KBFZWSXWHKXWFA-UHFFFAOYSA-N 0.000 description 1
- SBPTVFJEEQCSOA-UHFFFAOYSA-N CC(CCC(N1)=O)(C1=O)N(C(c1c2c(CNC(C3CC3)=O)ccc1)=O)C2=O Chemical compound CC(CCC(N1)=O)(C1=O)N(C(c1c2c(CNC(C3CC3)=O)ccc1)=O)C2=O SBPTVFJEEQCSOA-UHFFFAOYSA-N 0.000 description 1
- WXAXMYJQPUXINA-UHFFFAOYSA-N CC(CCC(N1)=O)(C1=O)N(C(c1c2c(NC(c3ccc[s]3)=O)ccc1)=O)C2=O Chemical compound CC(CCC(N1)=O)(C1=O)N(C(c1c2c(NC(c3ccc[s]3)=O)ccc1)=O)C2=O WXAXMYJQPUXINA-UHFFFAOYSA-N 0.000 description 1
- YMQPFBKEYDKSIP-UHFFFAOYSA-N CC(NCc1cccc2c1CN(C(CCC(N1)=O)C1=O)C2=O)=O Chemical compound CC(NCc1cccc2c1CN(C(CCC(N1)=O)C1=O)C2=O)=O YMQPFBKEYDKSIP-UHFFFAOYSA-N 0.000 description 1
- FPYSCUBOQCTDPU-UHFFFAOYSA-N CCC(Nc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O Chemical compound CCC(Nc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O FPYSCUBOQCTDPU-UHFFFAOYSA-N 0.000 description 1
- MLLZEXSWYDOQDE-UHFFFAOYSA-N CCCC(NCc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O Chemical compound CCCC(NCc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O MLLZEXSWYDOQDE-UHFFFAOYSA-N 0.000 description 1
- PMGYFRQTUOFKFJ-UHFFFAOYSA-N CCCCCNc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2ccc1 Chemical compound CCCCCNc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2ccc1 PMGYFRQTUOFKFJ-UHFFFAOYSA-N 0.000 description 1
- PDRWDMQFDDBMPT-UHFFFAOYSA-N CCOC(CNC(NCc1cccc(C(C#[O])N2C(CCC(N3)=O)C3=O)c1C2=O)=O)=O Chemical compound CCOC(CNC(NCc1cccc(C(C#[O])N2C(CCC(N3)=O)C3=O)c1C2=O)=O)=O PDRWDMQFDDBMPT-UHFFFAOYSA-N 0.000 description 1
- YFQWZWTYGJLUOC-UHFFFAOYSA-N CN(C)CC(NCc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O Chemical compound CN(C)CC(NCc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O YFQWZWTYGJLUOC-UHFFFAOYSA-N 0.000 description 1
- HWKZFWLDUJZNLU-UHFFFAOYSA-N Cc(cc1)ccc1C(Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O Chemical compound Cc(cc1)ccc1C(Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O HWKZFWLDUJZNLU-UHFFFAOYSA-N 0.000 description 1
- UDEZWTMCBWATIF-UHFFFAOYSA-N Cc1ccc(CNc2cccc(C(O)=O)c2C(O)=O)[o]1 Chemical compound Cc1ccc(CNc2cccc(C(O)=O)c2C(O)=O)[o]1 UDEZWTMCBWATIF-UHFFFAOYSA-N 0.000 description 1
- LPMWLZKQEVOOMZ-UHFFFAOYSA-N NCC(Nc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O Chemical compound NCC(Nc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O LPMWLZKQEVOOMZ-UHFFFAOYSA-N 0.000 description 1
- RZQHCMWISNAJBN-UHFFFAOYSA-N O=C(COCc1ccccc1)Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O Chemical compound O=C(COCc1ccccc1)Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O RZQHCMWISNAJBN-UHFFFAOYSA-N 0.000 description 1
- TYFWVUHGEDGFCZ-UHFFFAOYSA-N O=C(c1c2c(NCc3cnccc3)ccc1)N(C(CCC(N1)=O)C1=O)C2=O Chemical compound O=C(c1c2c(NCc3cnccc3)ccc1)N(C(CCC(N1)=O)C1=O)C2=O TYFWVUHGEDGFCZ-UHFFFAOYSA-N 0.000 description 1
- BQSYGXOLTFHQPO-UHFFFAOYSA-N O=C(c1cccc(NC(c2ccccc2)=[U])c11)N(C(CCC(N2)=O)C2=O)C1=O Chemical compound O=C(c1cccc(NC(c2ccccc2)=[U])c11)N(C(CCC(N2)=O)C2=O)C1=O BQSYGXOLTFHQPO-UHFFFAOYSA-N 0.000 description 1
- YPKGJVAMXZZNGJ-UHFFFAOYSA-N O=C(c1cccc(NCc2ccc[o]2)c11)N(C(CCC(N2)=O)C2=O)C1=O Chemical compound O=C(c1cccc(NCc2ccc[o]2)c11)N(C(CCC(N2)=O)C2=O)C1=O YPKGJVAMXZZNGJ-UHFFFAOYSA-N 0.000 description 1
- BIUYITAPSPGGPW-UHFFFAOYSA-N O=C(c1ccccn1)NCc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O Chemical compound O=C(c1ccccn1)NCc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O BIUYITAPSPGGPW-UHFFFAOYSA-N 0.000 description 1
- AXZONJHBMFYWII-UHFFFAOYSA-N OC(c1c(C(O)=O)c(NCc2cc(Cl)ccc2)ccc1)=O Chemical compound OC(c1c(C(O)=O)c(NCc2cc(Cl)ccc2)ccc1)=O AXZONJHBMFYWII-UHFFFAOYSA-N 0.000 description 1
- JQEQCBULHMUUKQ-UHFFFAOYSA-N OC(c1ccc(CNc2cccc(C(N3C(CCC(N4)=O)C4=O)=O)c2C3=O)[o]1)=O Chemical compound OC(c1ccc(CNc2cccc(C(N3C(CCC(N4)=O)C4=O)=O)c2C3=O)[o]1)=O JQEQCBULHMUUKQ-UHFFFAOYSA-N 0.000 description 1
- GCQYXHFKOBGGJG-CRAIPNDOSA-N O[C@H](c1cccc(NCc2ccc[o]2)c1C1)N1[C@H](CCC(N1)=O)C1=O Chemical compound O[C@H](c1cccc(NCc2ccc[o]2)c1C1)N1[C@H](CCC(N1)=O)C1=O GCQYXHFKOBGGJG-CRAIPNDOSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2433021A CA2433021C (en) | 2000-12-27 | 2001-12-21 | Isoindole-imide compounds, compositions, and uses thereof |
DE60126344T DE60126344T2 (de) | 2000-12-27 | 2001-12-21 | Isoindolimid-verbindungen, zusammensetzungen und verwendungen |
AU2002248252A AU2002248252B2 (en) | 2000-12-27 | 2001-12-21 | Isoindole-imide compounds, compositions, and uses thereof |
EP01997133A EP1363900B1 (en) | 2000-12-27 | 2001-12-21 | Isoindole-imide compounds, compositions and uses thereof |
IL15664601A IL156646A0 (en) | 2000-12-27 | 2001-12-21 | Isoindole-imide compounds, compositions, and uses thereof |
KR1020037008812A KR100747436B1 (ko) | 2000-12-27 | 2001-12-21 | 이소인돌-이미드 화합물 |
NZ526893A NZ526893A (en) | 2000-12-27 | 2001-12-21 | Isoindole-imide compounds, compositions, and uses thereof |
DK01997133T DK1363900T3 (da) | 2000-12-27 | 2001-12-21 | Isoindol-imid-forbindelser, præparater og anvendelser deraf |
JP2002559408A JP4284071B2 (ja) | 2000-12-27 | 2001-12-21 | イソインドール−イミド化合物、組成物、およびそれらの使用 |
KR1020077018941A KR100889116B1 (ko) | 2000-12-27 | 2001-12-21 | 이소인돌-이미드 화합물 |
HU0302578A HU229003B1 (hu) | 2000-12-27 | 2001-12-21 | Izoindol-imid típusú vegyületek, az ezeket tartalmazó készítmények és eljárás ezek alkalmazására |
MXPA03005786A MXPA03005786A (es) | 2000-12-27 | 2001-12-21 | Compuestos de isoindol-imida, composiciones que los contienen, y usos de los mismos. |
IL156646A IL156646A (en) | 2000-12-27 | 2003-06-25 | Isoindole-amide compounds, medicinal preparations containing them and their use in the preparation of medicines |
ZA2003/05759A ZA200305759B (en) | 2000-12-27 | 2003-07-25 | Isoindole-imide compounds compositions and uses thereof |
HK04102764A HK1061396A1 (en) | 2000-12-27 | 2004-04-20 | Isoindole-imide compounds, compositions and uses thereof |
AU2006200717A AU2006200717B8 (en) | 2000-12-27 | 2006-02-21 | Isoindole-imide compounds, compositions, and uses thereof |
CY20071100444T CY1106423T1 (el) | 2000-12-27 | 2007-03-29 | Ενωσεις ισοϊνδολο-ιμιδιου, συνθεσεις και χρησεις αυτων |
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