WO2000027819A2 - Anthranilsäureamide und deren verwendung als arzneimittel - Google Patents

Anthranilsäureamide und deren verwendung als arzneimittel Download PDF

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Publication number
WO2000027819A2
WO2000027819A2 PCT/EP1999/008478 EP9908478W WO0027819A2 WO 2000027819 A2 WO2000027819 A2 WO 2000027819A2 EP 9908478 W EP9908478 W EP 9908478W WO 0027819 A2 WO0027819 A2 WO 0027819A2
Authority
WO
WIPO (PCT)
Prior art keywords
group
stands
hydrogen
halogen
methyl
Prior art date
Application number
PCT/EP1999/008478
Other languages
German (de)
English (en)
French (fr)
Other versions
WO2000027819A3 (de
Inventor
Andreas Huth
Dieter Seidelmann
Karl-Heinz Thierauch
Guido Bold
Paul William Manley
Pascal Furet
Jeanette Marjorie Wood
Jürgen Mestan
Jose Brüggen
Stefano Ferrari
Martin Krüger
Eckhard Ottow
Andreas Menrad
Michael Schirner
Original Assignee
Schering Aktiengesellschaft
Novartis Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9824579.8A external-priority patent/GB9824579D0/en
Priority claimed from DE1999110396 external-priority patent/DE19910396C2/de
Priority to UA2001063917A priority Critical patent/UA71587C2/uk
Priority to CA002350208A priority patent/CA2350208A1/en
Priority to SK607-2001A priority patent/SK6072001A3/sk
Priority to NZ511413A priority patent/NZ511413A/en
Priority to HU0104425A priority patent/HUP0104425A3/hu
Priority to EA200100524A priority patent/EA004701B1/ru
Priority to AU10454/00A priority patent/AU771180B2/en
Priority to EP99953967A priority patent/EP1129074A2/de
Application filed by Schering Aktiengesellschaft, Novartis Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Priority to EEP200100258A priority patent/EE200100258A/xx
Priority to JP2000580999A priority patent/JP2002529452A/ja
Priority to US09/831,506 priority patent/US7122547B1/en
Priority to PL99348349A priority patent/PL348349A1/xx
Priority to BR9915553-2A priority patent/BR9915553A/pt
Publication of WO2000027819A2 publication Critical patent/WO2000027819A2/de
Publication of WO2000027819A3 publication Critical patent/WO2000027819A3/de
Priority to NO20012245A priority patent/NO320647B1/no
Priority to HK02103628A priority patent/HK1041882A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
PCT/EP1999/008478 1998-11-10 1999-11-09 Anthranilsäureamide und deren verwendung als arzneimittel WO2000027819A2 (de)

Priority Applications (15)

Application Number Priority Date Filing Date Title
UA2001063917A UA71587C2 (uk) 1998-11-10 1999-09-11 Аміди антранілової кислоти та їхнє застосування як лікарських засобів
PL99348349A PL348349A1 (en) 1998-11-10 1999-11-09 Antrhranilic acid amides and the use thereof as medicaments
BR9915553-2A BR9915553A (pt) 1998-11-10 1999-11-09 Amidas de ácido antranìlico e seu emprego como medicamento
JP2000580999A JP2002529452A (ja) 1998-11-10 1999-11-09 アントラニル酸アミド及び医薬剤としてのその使用
NZ511413A NZ511413A (en) 1998-11-10 1999-11-09 Antrhranilic acid amides and the use thereof as medicaments
HU0104425A HUP0104425A3 (en) 1998-11-10 1999-11-09 Anthranilic acid amides and the use thereof for the treatment of angiogenesis
EA200100524A EA004701B1 (ru) 1998-11-10 1999-11-09 Амиды антраниловой кислоты и их применение в качестве лекарственных средств
AU10454/00A AU771180B2 (en) 1998-11-10 1999-11-09 Antrhranilic acid amides and the use thereof as medicaments
EP99953967A EP1129074A2 (de) 1998-11-10 1999-11-09 Anthranilsäureamide und deren verwendung als arzneimittel
CA002350208A CA2350208A1 (en) 1998-11-10 1999-11-09 Antrhranilic acid amides and the use thereof as medicaments
EEP200100258A EE200100258A (et) 1998-11-10 1999-11-09 Antraniilhappe amiidid ja nende kasutamine ravimitena
SK607-2001A SK6072001A3 (en) 1998-11-10 1999-11-09 Anthranilic acid amides and the use thereof as medicaments
US09/831,506 US7122547B1 (en) 1998-11-10 1999-11-09 Anthranilic acid amides and the use thereof as medicaments
NO20012245A NO320647B1 (no) 1998-11-10 2001-05-07 Anthranilsyreamider og anvendelse derav for fremstilling av medikamenter
HK02103628A HK1041882A1 (en) 1998-11-10 2002-05-14 Anthranilic acid amides and their use in manufacturing pharmaceutical agents.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9824579.8A GB9824579D0 (en) 1998-11-10 1998-11-10 Organic compounds
GB9824579.8 1998-11-10
DE19910396.8 1999-03-03
DE1999110396 DE19910396C2 (de) 1999-03-03 1999-03-03 Anthranilsäureamide und deren Verwendung als Arzneimittel

Publications (2)

Publication Number Publication Date
WO2000027819A2 true WO2000027819A2 (de) 2000-05-18
WO2000027819A3 WO2000027819A3 (de) 2000-08-17

Family

ID=26052266

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/008478 WO2000027819A2 (de) 1998-11-10 1999-11-09 Anthranilsäureamide und deren verwendung als arzneimittel

Country Status (23)

Country Link
US (1) US7122547B1 (US07122547-20061017-C00064.png)
EP (1) EP1129074A2 (US07122547-20061017-C00064.png)
JP (1) JP2002529452A (US07122547-20061017-C00064.png)
KR (2) KR100777476B1 (US07122547-20061017-C00064.png)
CN (1) CN1151133C (US07122547-20061017-C00064.png)
AU (1) AU771180B2 (US07122547-20061017-C00064.png)
BG (1) BG65371B1 (US07122547-20061017-C00064.png)
BR (1) BR9915553A (US07122547-20061017-C00064.png)
CA (1) CA2350208A1 (US07122547-20061017-C00064.png)
CZ (1) CZ20011631A3 (US07122547-20061017-C00064.png)
EA (1) EA004701B1 (US07122547-20061017-C00064.png)
EE (1) EE200100258A (US07122547-20061017-C00064.png)
HK (1) HK1041882A1 (US07122547-20061017-C00064.png)
HR (1) HRP20010402A2 (US07122547-20061017-C00064.png)
HU (1) HUP0104425A3 (US07122547-20061017-C00064.png)
NO (1) NO320647B1 (US07122547-20061017-C00064.png)
NZ (1) NZ511413A (US07122547-20061017-C00064.png)
PL (1) PL348349A1 (US07122547-20061017-C00064.png)
SK (1) SK6072001A3 (US07122547-20061017-C00064.png)
TR (1) TR200101307T2 (US07122547-20061017-C00064.png)
UA (1) UA71587C2 (US07122547-20061017-C00064.png)
WO (1) WO2000027819A2 (US07122547-20061017-C00064.png)
YU (1) YU31801A (US07122547-20061017-C00064.png)

Cited By (131)

* Cited by examiner, † Cited by third party
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WO2001085719A1 (de) * 2000-05-09 2001-11-15 Schering Aktiengesellschaft Ortho substituierte anthranilsäureamide und deren verwendung als arzneimittel
WO2001085671A2 (de) * 2000-05-09 2001-11-15 Schering Aktiengesellschaft Anthranylamide und deren verwendung als arzneimittel
WO2001097786A2 (en) * 2000-06-21 2001-12-27 F. Hoffmann-La Roche Ag Benzothiazole derivatives
WO2002046181A2 (en) * 2000-12-07 2002-06-13 Cv Therapeutics, Inc. Abca-1 elevating compounds against coronary artery disease or atherosclerosis
WO2002066470A1 (en) * 2001-01-12 2002-08-29 Amgen Inc. Substituted alkylamine derivatives and methods of use
WO2002090352A2 (de) * 2001-05-08 2002-11-14 Schering Aktiengesellschaft Selektive anthranylamidpyridinamide als vegfr-2 und vegfr-3 inhibitoren
WO2002090349A1 (de) * 2001-05-08 2002-11-14 Schering Aktiengesellschaft N-oxidanthranylamid-derivate und deren verwendung als arzneimittel
DE10123587A1 (de) * 2001-05-08 2002-11-21 Schering Ag Cyanoanthranylamid-Derivate und deren Verwendung als Arzneimittel
DE10123573A1 (de) * 2001-05-08 2002-11-28 Schering Ag N-Oxidanthranylamid-Derivate und deren Verwendung als Arzneimittel
WO2002100833A1 (fr) * 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Inhibiteurs de rho kinase
WO2002055501A3 (en) * 2001-01-12 2002-12-19 Amgen Inc. N-pyridyl carboxamide derivatives and pharmaceutical compositions containing them
WO2003000678A1 (de) * 2001-05-08 2003-01-03 Schering Aktiengesellschaft Cyanoanthranylamid-derivate und deren verwendung als arzneimittel
WO2002068406A3 (en) * 2001-01-12 2003-04-24 Amgen Inc Substituted amine derivatives and their use for the treatment of angiogenesis
WO2004005279A2 (en) * 2002-07-09 2004-01-15 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
WO2004007481A2 (en) * 2002-07-17 2004-01-22 Amgen Inc. Substituted amine derivatives and methods of use in the treatment of angiogenesis relates disorders
WO2004007458A1 (en) 2002-07-17 2004-01-22 Amgen Inc. Substituted 2-alkylamine nicotinic amide derivatives and use there of
EP1388341A1 (en) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
DE10235690A1 (de) * 2002-07-31 2004-02-19 Schering Ag VEGFR-2 und VEGFR-3 inhibitorische Anthranylamidpyridinamide
WO2004050610A2 (en) * 2002-12-04 2004-06-17 Gene Logic Inc. Modulators of melanocortin receptor
WO2004063330A2 (en) 2003-01-06 2004-07-29 Osi Pharmaceuticals, Inc. (2-carboxamido) (3-amino) thiophene compounds
WO2004072069A1 (en) * 2003-02-14 2004-08-26 Glaxo Group Limited Carboxamide derivatives
WO2004078723A1 (ja) 2003-03-07 2004-09-16 Santen Pharmaceutical Co. Ltd. ４－ピリジルアルキルチオ基を置換基として有する新規化合物
US6818661B2 (en) * 2000-05-09 2004-11-16 Novartis Ag Anthranylalkyl and cycloalkyl amides and use thereof as VEGF receptor inhibitors
WO2004103306A2 (en) 2003-05-19 2004-12-02 Irm Llc Immunosuppressant compounds and compositions
WO2004108133A2 (en) * 2003-06-05 2004-12-16 Vertex Pharmaceuticals Incorporated Modulators of vr1 receptor
WO2004111005A1 (de) * 2003-06-13 2004-12-23 Schering Aktiengesellschaft Vegfr-2 und vegfr-3 inhibitorische anthranylamidpyridone
WO2005000833A1 (en) 2003-05-19 2005-01-06 Irm, Llc Immunosuppressant compounds and compositions
WO2005004864A1 (en) * 2003-07-11 2005-01-20 Merck Patent Gmbh Benzimidazole derivatives as raf kinase inhibitors
WO2004069792A3 (en) * 2003-02-03 2005-01-20 Janssen Pharmaceutica Nv Quinoline-derived amide modulators of vanilloid vr1 receptor
US6864255B2 (en) 2001-04-11 2005-03-08 Amgen Inc. Substituted triazinyl amide derivatives and methods of use
WO2005047273A1 (en) * 2003-11-14 2005-05-26 Novartis Ag Thiazole and pyrazole derivatives as flt-3 kinase inhibitors
WO2005054179A2 (en) 2003-12-03 2005-06-16 Leo Pharma A/S Hydroxamic acid esters and pharmaceutical use thereof
EP1568368A1 (en) * 2004-02-26 2005-08-31 Schering Aktiengesellschaft Pharmaceutical combination comprising a CDK inhibitor and a VEGF receptor inhibitor
WO2005085202A1 (de) * 2004-02-26 2005-09-15 Merck Patent Gmbh Pyridinamid-derivate als kinase-inhibitoren
WO2005085188A2 (en) * 2004-03-02 2005-09-15 Compass Pharmaceuticals Llc Compounds and methods for anti-tumor therapy
WO2006047574A1 (en) 2004-10-26 2006-05-04 Osi Pharmaceuticals, Inc. (2-carboxamido)(3-amino) thiophene compounds
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
US7094789B2 (en) 2002-07-22 2006-08-22 Asahi Kasei Pharma Corporation 5-substituted isoquinoline derivatives
US7101868B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted arylamine derivatives and methods of use
US7129245B2 (en) * 1998-12-23 2006-10-31 Eli Lilly And Company Aromatic amides
US7132438B2 (en) 2001-10-09 2006-11-07 Amgen Inc. Benzimidazole derivatives
CN1300113C (zh) * 2001-11-08 2007-02-14 诺瓦提斯公司 邻氨基苯甲酰胺和其作为vegf受体酪氨酸激酶抑制剂的用途
WO2007038459A2 (en) 2005-09-27 2007-04-05 Novartis Ag Carboxyamine compounds and their use in the treatment of hdac dependent diseases
US7202260B2 (en) 2003-06-13 2007-04-10 Schering Ag VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones
US7238808B2 (en) 2005-03-23 2007-07-03 Hoffmann-La Roche Inc. Acetylenyl-pyrazolo-pyrimidine derivatives
WO2007107543A1 (en) 2006-03-22 2007-09-27 Janssen Pharmaceutica N.V. Inhibitors of the interaction between mdm2 and p53
US7338956B2 (en) 2002-08-07 2008-03-04 Sanofi-Aventis Deutschland Gmbh Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
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UA71587C2 (uk) 2004-12-15
AU1045400A (en) 2000-05-29
HRP20010402A2 (en) 2003-10-31
NO320647B1 (no) 2006-01-09
BR9915553A (pt) 2001-08-14
KR20070087027A (ko) 2007-08-27
EP1129074A2 (de) 2001-09-05
AU771180B2 (en) 2004-03-18
EA004701B1 (ru) 2004-06-24
BG105588A (en) 2002-04-30
HUP0104425A3 (en) 2003-05-28
KR20010075689A (ko) 2001-08-09
WO2000027819A3 (de) 2000-08-17
HK1041882A1 (en) 2002-07-26
CZ20011631A3 (cs) 2001-10-17
NO20012245D0 (no) 2001-05-07
SK6072001A3 (en) 2002-01-07
JP2002529452A (ja) 2002-09-10

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