WO1998056431A1 - Implant injectable par voie sous-cutanee ou intradermique - Google Patents

Implant injectable par voie sous-cutanee ou intradermique Download PDF

Info

Publication number
WO1998056431A1
WO1998056431A1 PCT/FR1998/001241 FR9801241W WO9856431A1 WO 1998056431 A1 WO1998056431 A1 WO 1998056431A1 FR 9801241 W FR9801241 W FR 9801241W WO 9856431 A1 WO9856431 A1 WO 9856431A1
Authority
WO
WIPO (PCT)
Prior art keywords
microspheres
microparticles
implant
implant according
gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR1998/001241
Other languages
English (en)
French (fr)
Inventor
Jérôme ASIUS
Hatem Fessi
Franck Gouchet
Bénédicte Laglenne
Elisabeth Laugier-Laglenne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biopharmex Holding SA
Original Assignee
Biopharmex Holding SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9507929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998056431(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to HK00104039.5A priority Critical patent/HK1025268B/xx
Priority to EP98932196A priority patent/EP0969883B1/fr
Priority to DK98932196T priority patent/DK0969883T3/da
Priority to US09/242,103 priority patent/US6716251B1/en
Priority to HU0001465A priority patent/HU228462B1/hu
Priority to DE69819694T priority patent/DE69819694T2/de
Priority to RO99-00141A priority patent/RO118261B1/ro
Priority to CA002263361A priority patent/CA2263361C/fr
Application filed by Biopharmex Holding SA filed Critical Biopharmex Holding SA
Priority to IL12821098A priority patent/IL128210A/en
Priority to BR9804962-3A priority patent/BR9804962A/pt
Priority to JP11501805A priority patent/JP2000516839A/ja
Priority to AU82182/98A priority patent/AU744366B2/en
Priority to AT98932196T priority patent/ATE253947T1/de
Publication of WO1998056431A1 publication Critical patent/WO1998056431A1/fr
Anticipated expiration legal-status Critical
Priority to US10/809,349 priority patent/US7731758B2/en
Priority to US12/776,909 priority patent/US20100221684A1/en
Priority to US13/476,390 priority patent/US8414657B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/025—Explicitly spheroidal or spherical shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85—Polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0059—Cosmetic or alloplastic implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Definitions

  • the present invention relates to an injectable implant subcutaneously or intradermally, intended for use in humans in restorative or plastic surgery and in cosmetic dermatology, for the filling of wrinkles, fine lines, skin depressions, acne scars and hairs scars, as well as in dentistry for filling the gums.
  • silicone gel (or silicone oil) is easy to use. However, it has been observed, after injection, the migration of silicone droplets into the tissues situated below the injection point, by simple gravity. Silicone is frequently the cause of chronic inflammation, the formation of granulomas, and even late allergic reactions. Silicone is not biodegradable, and it is often found in the liver.
  • Teflon paste is a suspension of polytetrafluoroethylene particles (diameter 10 to 100 ⁇ ) in glycerin. This product, in many cases, caused severe and chronic serous infections, and had to be removed after a few months from the dermal and subdermal tissues for most patients. It has also been proven that small particles of polytetrafluoroethylene have been found in the liver.
  • Hyaluronate gels presented a good alternative due to their bio-compatibility and their absence of toxicity. They are also widely used in eye surgery. However, their rapid bio-absorbability (maximum 2 months) makes them ineffective for use in plastic surgery.
  • Bioplastics are polymerized silicone particles (diameter 70 to 140 ⁇ m) dispersed in polyvinylpyrrolidone. The product had to be removed due to the chronic inflammation and the rejection reactions it caused.
  • PMMA Polymethylmethacrylate
  • the object of the invention is to remedy the drawbacks of known products.
  • the invention makes use of microspheres or microparticles consisting of a neutral polymer chosen for its harmlessness and already used widely by the pharmaceutical industry, whether orally or parenterally.
  • the implant according to the invention combines the convenience of use without prior manipulation, the product's syringability, the resorbability in a controlled time of the polymer like carrier gel, the absence of allergenicity of the product, which makes any prior test unnecessary. .
  • microspheres or microparticles must have a controlled bio-absorbability ensuring a resorbability time of between 1 and 3 years. This means that the polymer will degrade after injection in situ into low molecular weight compounds which will be eliminated from the body by natural processes. In no case does a non-absorbable implant appear desirable. It is always a foreign body placed in a living tissue.
  • microspheres or microparticles are suspended in a gel. They must have a diameter greater than 5 ⁇ m, and preferably greater than 20 ⁇ m, so as not to be absorbed by the macrophages. They must have a diameter of less than 150 ⁇ m, and preferably less than 40 ⁇ m, so that on the one hand they can be injected with a fine needle and on the other hand they do not create granular clumps under the finger.
  • polycaprolactones and in particular poly-e-caprolactones
  • polylactides polylactic acids or PLA
  • polyglycolides polyglycolic acids or PGA
  • copolymers polylac acids - ticks-co-glycolics or PLAGA
  • PLA polylactic acid
  • PLAGA polylactic acid-co- glycolic
  • Its molecular mass calculated by viscosimetry is advantageously between 70,000 and 175,000 Dalton, and preferably between 120,000 and 170,000 Dalton, an intrinsic viscosity between 3 and 4 dl / g, and preferably between 3.35 and 3.65 dl / g , a specific rotation between -150 and -160 °, a melting point between 178.0 and 190, 1 ° C, a heat of fusion between 85.0 J / g and 90.0 J / g, a amount of residual solvents ⁇ 0.01% and a proportion of residual monomer (lactic acid) ⁇ 0.1%.
  • Such a product is available from PURAC 3I0CHEM in Gorinchem (Netherlands).
  • Bio-absorbable synthetic polymers have been studied for fifteen years under the direction of Michel VERT, director of research at C.N.R.S. The first clinical uses of PLA began in 1981 for various indications in facial trauma. Lactic acid polymers have seen their use systematized in the context of bio-absorbable surgical implants. PLA's medical applications are today diversified and extensive (bone surgery, maxillofacial surgery, pharmacological formulations with controlled release: implants, microspheres, nanospheres, vaccines).
  • the degradation of lactic acid and / or glycolic acid polymers in a biological medium takes place exclusively by a non-specific chemical hydrolysis mechanism.
  • the products of this hydrolysis are then metabolized and eliminated by the human body.
  • the chemical hydrolysis of the polymer is complete; it intervenes all the more quickly when its amorphous character is pronounced and when its molecular mass is low.
  • the resorbability time can be adjusted by acting on the composition of the mixture and / or on the molecular mass of the polymer (s).
  • the biocompatibility of PLA and PLAGA polymers makes them excellent supports for cell growth and tissue regeneration.
  • the microspheres or micrcarticles are included in a gel.
  • This gel used as a vector to maintain the microspheres or microparticles in homogeneous suspension, is absorbable in about 2 months, which corresponds to the time necessary for the creation of fibrosis around the microspheres or microparticles.
  • It mainly consists of water for injections and a gelling agent authorized for injection: cellulose derivatives, and more particularly carboxymethylcellulose (CMC) at a mass concentration of 0.1 to 7.5%, and preferably from 0.1 to 5.0%.
  • Hydroxypropylmethylcellulose (HPMC) can also be used, which is commonly used in intraocular injection for cataract operations.
  • a synthetic hyaiuronic acid can also be used, used for intraocular injections and subcutaneous injections. It is also possible to use lactic acid esters, caproic acid esters, etc.
  • the good dispersion of the microspheres or microparticles and the homogeneity of the gel will be ensured by the use of a surfactant, chosen for its safety and its authorized use in subcutaneous and intra-dermal.
  • a surfactant chosen for its safety and its authorized use in subcutaneous and intra-dermal.
  • Polyoxyethylene sorbitan monooleate (sold under the name Tween 80) or pluronic acid will be used.
  • the product can be presented in sterile pre-filled syringes ready for use, provided with a needle, or in bottles of sterile suspension. It can also be presented in a vial containing a lyophilisate accompanied by an ampoule of sterile water (water for injection), or in a pre-filled syringe with two compartments, one containing the lyophilisate of microspheres or microparticles, the other containing water for injection.
  • the implant does not require an allergenicity test. It does not contain any animal products.
  • the implant manufacturing protocol is described below, in the case of a ready-to-use suspension of microspheres.
  • the conventional technique is used by solvent evaporation, or the technique known as controlled precipitation, or any other technique allowing microspheres of desired size to be obtained.
  • the manufacturing protocol is described below in the case of lyophilized PLA microparticles, whether it is polymer L, polymer D or a mixture of these.
  • microparticles or microspheres being made up of any one of the polymers mentioned above and their mixtures.
  • PLA 2 g
  • an organic solvent methylene chloride
  • This solution is dispersed in 100 ml of water containing 5 g of polyoxyethylene sorbitan monooleate.
  • Moderate stirring with a vortex is maintained until the solvent has evaporated and microspheres with an average diameter of 80 ⁇ m are formed.
  • the microspheres formed are recovered by sedimentation, filtration and drying. They are then included in a gel consisting of water and CMC (0.5% by mass). After moderate agitation, the distribution is carried out.
  • 600 g of polylactic acid are freeze-grinded, with a final particle size of between 20 and 100 ⁇ m, with a median of 40 ⁇ m. These microparticles are distributed at a rate of 100 mg per bottle.
  • 6.5 kg of lyophilization medium are produced by dissolving 97.5 g of sodium CMC, 276.25 g of pyrogen-free mannitol, and 6.5 g of polysorbate 80 in qs 6.5 liters of water for injection. This medium is distributed at a rate of 1 g per bottle. Animal tests (hairless mice and New Zealand rabbits) were carried out with the products of examples 1 to 4. The results are identical, and are observed during the first two months, and from the eighth day after the injection. , the appearance of giant cells surrounding the polylactic acid crystals in a network, then their transformation by creation of a fibrosis which reconstitutes the subcutaneous tissue.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PCT/FR1998/001241 1997-06-13 1998-06-12 Implant injectable par voie sous-cutanee ou intradermique Ceased WO1998056431A1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
AT98932196T ATE253947T1 (de) 1997-06-13 1998-06-12 Subkutan oder intradermal injizierbares implantat in der plastischen oder wiederherstellenden chirurgie
EP98932196A EP0969883B1 (fr) 1997-06-13 1998-06-12 Implant injectable par voie sous-cutanee ou intradermique
DK98932196T DK0969883T3 (da) 1997-06-13 1998-06-12 Subcutant eller intradermalt injicerbart implantat
US09/242,103 US6716251B1 (en) 1997-06-13 1998-06-12 Implant for subcutaneous or intradermal injection
HU0001465A HU228462B1 (en) 1997-06-13 1998-06-12 Implant for subcutaneous or intradermal injection
DE69819694T DE69819694T2 (de) 1997-06-13 1998-06-12 Subkutan oder intradermal injizierbares implantat in der plastischen oder wiederherstellenden chirurgie
RO99-00141A RO118261B1 (ro) 1997-06-13 1998-06-12 Implant injectabil pentru administrare la om
CA002263361A CA2263361C (fr) 1997-06-13 1998-06-12 Implant injectable par voie sous-cutanee ou intradermique
IL12821098A IL128210A (en) 1997-06-13 1998-06-12 Implant for subcutaneous or intradermal injection
HK00104039.5A HK1025268B (en) 1997-06-13 1998-06-12 Implant for subcutaneous or intradermal injection
AU82182/98A AU744366B2 (en) 1997-06-13 1998-06-12 Implant for subcutaneous or intradermal injection
JP11501805A JP2000516839A (ja) 1997-06-13 1998-06-12 皮下注入用、あるいは皮内注入用インプラント
BR9804962-3A BR9804962A (pt) 1997-06-13 1998-06-12 Implante injetável para a administração humana e liofilizado obtido pela liofilização de um produto
US10/809,349 US7731758B2 (en) 1997-06-13 2004-03-26 Implant for subcutaneous or intradermal injection
US12/776,909 US20100221684A1 (en) 1997-06-13 2010-05-10 Implant for subcutaneous or intradermal injection
US13/476,390 US8414657B2 (en) 1997-06-13 2012-05-21 Method for subcutaneous or intradermal injection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR97/07334 1997-06-13
FR9707334A FR2764514B1 (fr) 1997-06-13 1997-06-13 Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US09242103 A-371-Of-International 1998-06-12
US09/242,103 A-371-Of-International US6716251B1 (en) 1997-06-13 1998-06-12 Implant for subcutaneous or intradermal injection
US10/809,349 Division US7731758B2 (en) 1997-06-13 2004-03-26 Implant for subcutaneous or intradermal injection

Publications (1)

Publication Number Publication Date
WO1998056431A1 true WO1998056431A1 (fr) 1998-12-17

Family

ID=9507929

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1998/001241 Ceased WO1998056431A1 (fr) 1997-06-13 1998-06-12 Implant injectable par voie sous-cutanee ou intradermique

Country Status (20)

Country Link
US (4) US6716251B1 (https=)
EP (1) EP0969883B1 (https=)
JP (1) JP2000516839A (https=)
KR (1) KR100543560B1 (https=)
AT (1) ATE253947T1 (https=)
AU (1) AU744366B2 (https=)
BR (1) BR9804962A (https=)
CA (1) CA2263361C (https=)
DE (1) DE69819694T2 (https=)
DK (1) DK0969883T3 (https=)
ES (1) ES2210776T3 (https=)
FR (1) FR2764514B1 (https=)
HU (1) HU228462B1 (https=)
IL (1) IL128210A (https=)
PL (1) PL331703A1 (https=)
PT (1) PT969883E (https=)
RO (1) RO118261B1 (https=)
RU (1) RU2214283C2 (https=)
TR (1) TR199900297T1 (https=)
WO (1) WO1998056431A1 (https=)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2778847A1 (fr) * 1998-05-20 1999-11-26 Jean Pierre Perraud Implant injectable en sous gingival resorbable, constitue de microspheres a liberation prolongee et chargees en principes actifs et en suspension dans un gel vecteur
DE10026620A1 (de) * 2000-05-29 2002-03-07 Gerhard Quelle Poröse Implantate und Partikel
US6423332B1 (en) 2000-05-26 2002-07-23 Ethicon, Inc. Method and composition for deforming soft tissues
FR2850282A1 (fr) * 2003-01-27 2004-07-30 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
EP1389468A4 (en) * 2001-05-23 2007-01-10 Tanabe Seiyaku Co COMPOSITIONS FOR PROMOTING BONE FRACTURE HEALING
EP1389467A4 (en) * 2001-05-23 2007-01-10 Tanabe Seiyaku Co THERAPEUTIC COMPOSITIONS FOR THE REPAIR OF CHONDROPATHY
US7314636B2 (en) 2001-06-29 2008-01-01 Medgraft Microtech, Inc. Biodegradable injectable implants containing glycolic acid
WO2009014441A2 (en) 2007-07-26 2009-01-29 Aqtis Ip Bv Microparticles comprising pcl and uses thereof
WO2018219987A1 (en) 2017-05-30 2018-12-06 Aqpha Ip B.V. Resorbable biodegradable medical and cosmetic composition comprising poly(1,3-trimethylene carbonate)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764514B1 (fr) 1997-06-13 1999-09-03 Biopharmex Holding Sa Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique
JP2003509128A (ja) * 1999-09-14 2003-03-11 テファ， インコーポレイテッド 軟部組織の修復、増強および粘性補充のためのポリヒドロキシアルカノエート組成物
US7666588B2 (en) * 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7419949B2 (en) * 2001-07-16 2008-09-02 Novo Noridsk Healthcare A/G Single-dose administration of factor VIIa
US7744651B2 (en) * 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
US20040054414A1 (en) 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
JP2006515765A (ja) * 2002-11-15 2006-06-08 エスディージーアイ・ホールディングス・インコーポレーテッド 滑膜性関節を治療するためのコラーゲンベース材料および方法
US20040186471A1 (en) * 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
US7965719B2 (en) * 2002-12-11 2011-06-21 Broadcom Corporation Media exchange network supporting multiple broadband network and service provider infrastructures
EA200501422A1 (ru) * 2003-03-04 2006-04-28 Дзе Текнолоджи Девелопмент Компани Лтд. Длительнодействующая инъецируемая композиция инсулина и способы её изготовления и применения
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
US7754233B2 (en) * 2004-09-03 2010-07-13 Ethicon, Inc. Method of preventing post-operative surgical adhesion
US8440215B2 (en) * 2004-09-03 2013-05-14 Ethicon, Inc. Absorbable polymer formulations
US7641688B2 (en) * 2004-09-16 2010-01-05 Evera Medical, Inc. Tissue augmentation device
US20060058891A1 (en) * 2004-09-16 2006-03-16 Lesh Michael D Transformable tissue bulking device
US7244270B2 (en) * 2004-09-16 2007-07-17 Evera Medical Systems and devices for soft tissue augmentation
BRPI0515337A (pt) * 2004-09-16 2008-07-22 Juva Medical Inc dispositivo de aumento de tecido
ITPD20040312A1 (it) * 2004-12-15 2005-03-15 Fidia Advanced Biopolymers Srl Protesi e o supporto per la sostituzione, riparazione, rigenerazione del menisco
US7767656B2 (en) * 2005-04-25 2010-08-03 Molly S Shoichet Blends of temperature sensitive and anionic polymers for drug delivery
US9205047B2 (en) * 2005-04-25 2015-12-08 The Governing Council Of The University Of Toronto Tunable sustained release of a sparingly soluble hydrophobic therapeutic agent from a hydrogel matrix
WO2007056142A2 (en) * 2005-11-02 2007-05-18 Theraquest Biosciences, Llc Methods of preventing the serotonin syndrome and compositions for use therefor
WO2008134071A1 (en) * 2007-04-26 2008-11-06 Theraquest Biosciences, Inc. Multimodal abuse resistant extended release formulations
US20090082466A1 (en) * 2006-01-27 2009-03-26 Najib Babul Abuse Resistant and Extended Release Formulations and Method of Use Thereof
US8329744B2 (en) * 2005-11-02 2012-12-11 Relmada Therapeutics, Inc. Methods of preventing the serotonin syndrome and compositions for use thereof
JP2009521493A (ja) * 2005-12-23 2009-06-04 アルコン，インコーポレイテッド 眼への受容体チロシンキナーゼ阻害（ＲＴＫｉ）化合物の送達のための医薬製剤
FR2895907B1 (fr) * 2006-01-06 2012-06-01 Anteis Sa Gel viscoelastique a usage dermatologique
FR2897775B1 (fr) * 2006-02-24 2013-05-03 Elisabeth Laugier Biomateriau, implant injectable le comprenant, son procede de preparation et ses utilisations
US8580307B2 (en) 2006-06-22 2013-11-12 Ethicon, Inc. High glass transition temperature absorbable microspheres
US9119902B2 (en) 2006-06-22 2015-09-01 Ethicon, Inc. Semi-crystalline absorbable microspheres
US20080004431A1 (en) * 2006-06-30 2008-01-03 Warsaw Orthopedic Inc Method of manufacturing an injectable collagen material
US8399619B2 (en) * 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
US8118779B2 (en) * 2006-06-30 2012-02-21 Warsaw Orthopedic, Inc. Collagen delivery device
US20080069871A1 (en) * 2006-07-21 2008-03-20 Vaughn Jason M Hydrophobic abuse deterrent delivery system
US20080107744A1 (en) * 2006-11-06 2008-05-08 Jack Fa-De Chu Injectable hollow tissue filler
WO2008066382A1 (en) * 2006-11-29 2008-06-05 Cam Aesthetics B.V. I.O. Carboxymethyl cellulose-stabilised tissue filler and its preparation and use
KR100759091B1 (ko) 2006-12-13 2007-09-17 조강선 피부 충전제 조성물
US7776840B2 (en) 2007-02-21 2010-08-17 Cutanea Life Sciences, Inc. Methods of use of biomaterial and injectable implant containing biomaterial
JP2010528039A (ja) * 2007-05-23 2010-08-19 アラーガン、インコーポレイテッド 被覆されたヒアルロン酸粒子
US20080293637A1 (en) * 2007-05-23 2008-11-27 Allergan, Inc. Cross-linked collagen and uses thereof
US8318695B2 (en) * 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
US20110077737A1 (en) * 2007-07-30 2011-03-31 Allergan, Inc. Tunably Crosslinked Polysaccharide Compositions
US20090081173A1 (en) * 2007-08-10 2009-03-26 The Board Of Regents Of The University Of Texas System Methods and compositions involving bacteriophage isolates
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
US8475815B2 (en) * 2007-10-29 2013-07-02 Ayman Boutros Alloplastic injectable dermal filler and methods of use thereof
US7910134B2 (en) * 2007-10-29 2011-03-22 Ayman Boutros Alloplastic injectable dermal filler and methods of use thereof
US8709395B2 (en) 2007-10-29 2014-04-29 Ayman Boutros Method for repairing or replacing damaged tissue
US8431141B2 (en) * 2007-10-29 2013-04-30 Ayman Boutros Alloplastic injectable dermal filler and methods of use thereof
JP5670196B2 (ja) 2007-11-16 2015-02-18 バイセプト セラピューティクス、インク． 紫斑を治療する組成物および方法
US8394782B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
WO2009079555A2 (en) * 2007-12-17 2009-06-25 Anna Love Soft tissue filler
US20090198329A1 (en) 2008-02-01 2009-08-06 Kesten Randy J Breast implant with internal flow dampening
US20090198331A1 (en) * 2008-02-01 2009-08-06 Kesten Randy J Implantable prosthesis with open cell flow regulation
US8678008B2 (en) * 2008-07-30 2014-03-25 Ethicon, Inc Methods and devices for forming an auxiliary airway for treating obstructive sleep apnea
US8556797B2 (en) * 2008-07-31 2013-10-15 Ethicon, Inc. Magnetic implants for treating obstructive sleep apnea and methods therefor
US8357795B2 (en) * 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
US8413661B2 (en) 2008-08-14 2013-04-09 Ethicon, Inc. Methods and devices for treatment of obstructive sleep apnea
ES2658609T3 (es) 2008-09-02 2018-03-12 Tautona Group Lp Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos, y usos de los mismos
US20100080791A1 (en) * 2008-09-26 2010-04-01 Rousseau Robert A Composition and Method For Treating Tissue Defects
US8561616B2 (en) 2008-10-24 2013-10-22 Ethicon, Inc. Methods and devices for the indirect displacement of the hyoid bone for treating obstructive sleep apnea
US8561617B2 (en) 2008-10-30 2013-10-22 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US8783258B2 (en) 2008-12-01 2014-07-22 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US8800567B2 (en) 2008-12-01 2014-08-12 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US8371308B2 (en) 2009-02-17 2013-02-12 Ethicon, Inc. Magnetic implants and methods for treating an oropharyngeal condition
US8307831B2 (en) 2009-03-16 2012-11-13 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US10105197B1 (en) 2009-03-26 2018-10-23 Fernando Colon Method of treatment for periodontal pockets
US9200112B2 (en) 2009-08-10 2015-12-01 Ethicon, Inc. Semi-crystalline, fast absorbing polymer formulation
US9877862B2 (en) 2009-10-29 2018-01-30 Ethicon, Inc. Tongue suspension system with hyoid-extender for treating obstructive sleep apnea
US9326886B2 (en) 2009-10-29 2016-05-03 Ethicon, Inc. Fluid filled implants for treating obstructive sleep apnea
US9974683B2 (en) * 2009-10-30 2018-05-22 Ethicon, Inc. Flexible implants having internal volume shifting capabilities for treating obstructive sleep apnea
US9044524B2 (en) * 2009-10-30 2015-06-02 Ethicon, Inc. Absorbable polyethylene diglycolate copolymers to reduce microbial adhesion to medical devices and implants
US8632488B2 (en) 2009-12-15 2014-01-21 Ethicon, Inc. Fluid filled implants for treating medical conditions
EP2512516B1 (en) 2009-12-18 2016-02-17 The Governing Council Of The University Of Toronto Injectable polymer composition for use as a cell delivery vehicle
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
KR101764451B1 (ko) 2010-03-12 2017-08-02 알러간 인더스트리 에스에이에스 피부 상태 개선을 위한 히알루론안 폴리머 및 만니톨을 포함하는 유체 조성물
EP3078388B1 (en) 2010-03-22 2019-02-20 Allergan, Inc. Cross-linked hydrogels for soft tissue augmentation
US8815228B2 (en) 2010-04-30 2014-08-26 Ayman Boutros Alloplastic injectable dermal filler and methods of use thereof
KR101003331B1 (ko) 2010-05-11 2010-12-23 조강선 피부 충전제 조성물
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
KR102238406B1 (ko) 2011-06-03 2021-04-08 알러간 인더스트리 에스에이에스 항산화제를 포함하는 피부 충전제 조성물
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US8905033B2 (en) 2011-09-28 2014-12-09 Ethicon, Inc. Modular tissue securement systems
US9161855B2 (en) 2011-10-24 2015-10-20 Ethicon, Inc. Tissue supporting device and method
US8973582B2 (en) 2011-11-30 2015-03-10 Ethicon, Inc. Tongue suspension device and method
US10470760B2 (en) 2011-12-08 2019-11-12 Ethicon, Inc. Modified tissue securement fibers
US9173766B2 (en) 2012-06-01 2015-11-03 Ethicon, Inc. Systems and methods to treat upper pharyngeal airway of obstructive sleep apnea patients
EP3200838B1 (en) 2014-09-30 2019-09-18 Allergan Industrie, SAS Stable hydrogel compositions including additives
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
HUE047971T2 (hu) 2015-02-13 2020-05-28 Allergan Ind Sas Az arcelemek - például az áll - formázására, megnagyobbítására vagy korrekciójára szolgáló implantátumok
US11254792B2 (en) 2015-12-29 2022-02-22 Galderma Holding SA Method for deacetylation of biopolymers
CN105664261B (zh) * 2016-02-18 2018-09-21 江苏西宏生物医药有限公司 一种注射植入剂的制备方法
CN105727370B (zh) * 2016-02-18 2018-11-06 江苏西宏生物医药有限公司 一种注射植入剂
KR101852127B1 (ko) 2016-04-11 2018-04-25 주식회사 지씨에스 폴리엘락틱산 필러와 히알루론산 필러 결합체의 제조방법
RU2641053C1 (ru) * 2016-09-21 2018-01-15 Наталья Павловна Михайлова Твёрдофазный способ получения биоактивного композита для наращивания ткани на основе гиалуроновой кислоты и микрочастиц полилактида или его сополимеров и способ получения имплантата на основе этого композита
US10821200B2 (en) * 2016-12-05 2020-11-03 Hyalo Technologies, LLC Method of sterilization of microparticles
CN108619564A (zh) * 2017-03-18 2018-10-09 浙江臻我生物技术有限公司 一种用于皮肤填充的组合物及其制备方法
CN108619563A (zh) * 2017-03-18 2018-10-09 浙江臻我生物技术有限公司 一种聚乳酸组合物及其制备方法
FI3897763T3 (fi) * 2018-12-21 2025-06-24 Galderma Holding SA Kiinteitä hiukkasia kapseloivat hydrogeelikoostumukset
EP3730161A4 (en) * 2019-03-08 2021-07-14 GCS Co., Ltd. COMPLEX PRODUCTION PROCESS
US20200376128A1 (en) 2019-06-01 2020-12-03 Lupin Holdings B.V. Monodisperse resorbable polyester polymer compositions, systems, and methods
CN110339397B (zh) * 2019-07-11 2021-12-21 山东省药学科学院 一种不含助悬剂的可注射皮肤填充剂及其制备方法和用途
CN110327497A (zh) * 2019-07-31 2019-10-15 易浦润（上海）生物技术有限公司 一种含微球的注射用凝胶及其制备方法
TWI894176B (zh) * 2019-10-28 2025-08-21 瑞士商葛德瑪控股公司 即用型美容組成物
AU2020395955A1 (en) 2019-12-02 2022-07-14 Galderma Holding SA High molecular weight esthetic compositions
CN113058074B (zh) * 2020-01-02 2022-04-29 华利源(上海)生物医药科技有限公司 温敏填充剂组合物
CN113117143B (zh) * 2020-01-14 2023-11-28 渼颜空间(河北)生物科技有限公司 透明质酸用于制备可生物降解的聚合物微粒制剂的应用
CN111150883A (zh) * 2020-01-14 2020-05-15 北京四环制药有限公司 可生物降解的注射填充物及其制备方法和其应用
CN114099771A (zh) * 2020-08-27 2022-03-01 杭州协合医疗用品有限公司 一种含混合聚合物微球的梯度注射剂
US12453805B2 (en) 2020-09-24 2025-10-28 Everest Medical Innovation GmbH Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery
US12426594B2 (en) 2020-09-24 2025-09-30 Everest Medical Innovation GmbH Cryoprotective compositions and methods for protection of a surgical site during cryosurgery
KR102266384B1 (ko) * 2021-01-25 2021-06-21 주식회사 울트라브이 필러용 생분해성 고분자 미세입자, 이를 포함한 필러용 동결건조체, 그 제조방법 및 상기 동결건조체를 포함하는 필러용 주사제
CN113877000B (zh) * 2021-10-13 2023-01-24 科笛生物医药(无锡)有限公司 注射用微球组合物及其应用
CN116672498B (zh) * 2022-02-23 2025-07-01 济南格莱威医疗科技有限公司 一种注射用复合材料及其用途
KR102587872B1 (ko) * 2022-06-14 2023-10-12 주식회사 바임 복합체, 이의 제조방법 및 이를 이용한 성형용 필러 조성물
IN202411028038A (https=) * 2024-04-04 2025-05-23

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0251695A2 (en) * 1986-06-25 1988-01-07 Collagen Corporation Injectable implant composition having improved intrudability
WO1993013755A1 (fr) * 1992-01-16 1993-07-22 Coletica Composition injectable contenant des microcapsules de collagene
US5258028A (en) * 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
EP0648480A2 (en) * 1993-09-21 1995-04-19 JOHNSON & JOHNSON MEDICAL, INC. Wound implant materials
US5451406A (en) * 1994-07-14 1995-09-19 Advanced Uroscience, Inc. Tissue injectable composition and method of use
EP0711548A1 (en) * 1994-10-18 1996-05-15 Ethicon, Inc. Injectable microdispersions for soft tissue repair and augmentation
WO1996033751A1 (fr) * 1995-04-25 1996-10-31 W.K. Et Associes Compositions biphasiques injectables renfermant de l'acide hyaluronique, notamment utiles en chirurgies reparatrice et esthetique

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2185152A (en) * 1939-12-26 Diazo derivatives of gtjanidyl
US2756867A (en) * 1950-11-21 1956-07-31 Joy Mfg Co Conveyor chain with replaceable flights
US2758987A (en) 1952-06-05 1956-08-14 Du Pont Optically active homopolymers containing but one antipodal species of an alpha-monohydroxy monocarboxylic acid
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
CH530951A (de) * 1970-08-04 1972-11-30 Ciba Geigy Ag Verfahren zur Herstellung von 2,3-disubstituierten 1,3-Butadienen
CH611150A5 (https=) * 1975-04-18 1979-05-31 Sulzer Ag
US4166800A (en) * 1977-08-25 1979-09-04 Sandoz, Inc. Processes for preparation of microspheres
US4919929A (en) 1984-02-01 1990-04-24 Stolle Research & Development Corporation Mammal immunization
CA1196864A (en) 1983-06-10 1985-11-19 Mattheus F.A. Goosen Controlled release of injectable and implantable insulin compositions
DE3689650T2 (de) * 1985-12-17 1994-05-26 United States Surgical Corp Bioresorbierbare Polymere von hohem Molekulargewicht und Implantate davon.
US5061281A (en) * 1985-12-17 1991-10-29 Allied-Signal Inc. Bioresorbable polymers and implantation devices thereof
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
JPS63122620A (ja) * 1986-11-12 1988-05-26 Sanraku Inc ポリ乳酸マイクロスフエア及びその製造方法
FR2618674B1 (fr) 1987-07-30 1990-06-15 Ire Celltarg Sa Microparticules comportant un polymere biodegradable controlant la liberation d'un principe actif antimalarique, compositions pharmaceutiques en comprenant et procede de preparation
US4969912A (en) * 1988-02-18 1990-11-13 Kelman Charles D Human collagen processing and autoimplant use
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
US4897287A (en) 1988-10-06 1990-01-30 The Boc Group, Inc. Metallization process for an integrated circuit
DE3841401A1 (de) 1988-12-08 1990-06-13 Martin Lemperle Alloplastisches implantat
US5185152A (en) 1990-01-10 1993-02-09 Peyman Gholam A Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye
US5059123A (en) 1990-05-14 1991-10-22 Jernberg Gary R Periodontal barrier and method for aiding periodontal tissue regeneration
US5288496A (en) 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
WO1993000050A1 (en) * 1991-06-21 1993-01-07 Genetics Institute, Inc. Pharmaceutical formulations of osteogenic proteins
US5356629A (en) * 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
DE4235312A1 (de) 1991-10-23 1993-04-29 Boehringer Ingelheim Kg Halbfeste mischungen aus oligomeren und/oder polymeren auf der basis von milchsaeure, verfahren zu deren herstellung und deren verwendung als resorbierbare implantate
JPH05194189A (ja) * 1991-10-23 1993-08-03 Boehringer Ingelheim Kg 乳酸に基づくオリゴマー及び／又はポリマーの半固形混合物、それらの製造方法並びに吸収性埋め込み物としてのそれらの使用
WO1993015722A1 (en) 1992-02-07 1993-08-19 Syntex (Usa) Inc. Controlled delivery of pharmaceuticals from preformed porous microparticles
ZA93506B (en) * 1992-02-11 1994-05-11 Bristol Myers Squibb Co Soft tissue augmentation material
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
GB9206509D0 (en) * 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges containing active agents
SE509991C2 (sv) 1992-07-20 1999-03-29 Bengt Hjalmar Aagerup Med Firm Biologiskt nedbrytbar vävnadsförstärkning
RU2034465C1 (ru) * 1992-08-05 1995-05-10 Малое Внедренческое Предприятие "Интерфалл" Состав для инъекции при эндопротезировании
ZA938595B (en) * 1992-12-23 1994-08-05 Ndm Acquisition Corp Wound dressing having a cylindrical shape for deep wounds.
WO1994021299A1 (en) 1993-03-19 1994-09-29 Medinvent A composition and a method for tissue augmentation
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
JPH07125508A (ja) 1993-09-09 1995-05-16 Bridgestone Corp 空気入りタイヤ
JPH07265421A (ja) 1994-03-28 1995-10-17 Shibuya Kogyo Co Ltd ダブルチャンバーシリンジの製造方法
US5478837A (en) 1994-06-07 1995-12-26 University Of Southern California Use of quinacrine in preventing adhesion formation
UA10911C2 (uk) * 1994-08-10 1996-12-25 Мале Впроваджувальне Підприємство "Іhтерфалл" Біосумісhий гідрогель
AU706434B2 (en) * 1994-10-18 1999-06-17 Ethicon Inc. Injectable liquid copolymers for soft tissue repair and augmentation
US6287341B1 (en) * 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
US5977204A (en) * 1997-04-11 1999-11-02 Osteobiologics, Inc. Biodegradable implant material comprising bioactive ceramic
FR2764514B1 (fr) * 1997-06-13 1999-09-03 Biopharmex Holding Sa Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique
US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
AU9313298A (en) * 1997-09-04 1999-03-22 Point Biomedical Corporation Injectable tissue reconstruction material
WO1999058082A2 (en) * 1998-05-14 1999-11-18 The Cleveland Clinic Foundation Processing of implantable animal tissues for dry storage
FR2778847A1 (fr) * 1998-05-20 1999-11-26 Jean Pierre Perraud Implant injectable en sous gingival resorbable, constitue de microspheres a liberation prolongee et chargees en principes actifs et en suspension dans un gel vecteur
DE60136815D1 (de) * 2000-07-14 2009-01-15 Kyphon Inc Vorrichtungen zur behandlung von wirbelkoerpern

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0251695A2 (en) * 1986-06-25 1988-01-07 Collagen Corporation Injectable implant composition having improved intrudability
US5258028A (en) * 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
WO1993013755A1 (fr) * 1992-01-16 1993-07-22 Coletica Composition injectable contenant des microcapsules de collagene
EP0648480A2 (en) * 1993-09-21 1995-04-19 JOHNSON & JOHNSON MEDICAL, INC. Wound implant materials
US5451406A (en) * 1994-07-14 1995-09-19 Advanced Uroscience, Inc. Tissue injectable composition and method of use
EP0711548A1 (en) * 1994-10-18 1996-05-15 Ethicon, Inc. Injectable microdispersions for soft tissue repair and augmentation
WO1996033751A1 (fr) * 1995-04-25 1996-10-31 W.K. Et Associes Compositions biphasiques injectables renfermant de l'acide hyaluronique, notamment utiles en chirurgies reparatrice et esthetique

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2778847A1 (fr) * 1998-05-20 1999-11-26 Jean Pierre Perraud Implant injectable en sous gingival resorbable, constitue de microspheres a liberation prolongee et chargees en principes actifs et en suspension dans un gel vecteur
US6423332B1 (en) 2000-05-26 2002-07-23 Ethicon, Inc. Method and composition for deforming soft tissues
DE10026620A1 (de) * 2000-05-29 2002-03-07 Gerhard Quelle Poröse Implantate und Partikel
EP1389468A4 (en) * 2001-05-23 2007-01-10 Tanabe Seiyaku Co COMPOSITIONS FOR PROMOTING BONE FRACTURE HEALING
EP1389467A4 (en) * 2001-05-23 2007-01-10 Tanabe Seiyaku Co THERAPEUTIC COMPOSITIONS FOR THE REPAIR OF CHONDROPATHY
US7887599B2 (en) 2001-06-29 2011-02-15 Crisoforo Peralta Casares Methods of use of biodegradable injectable implants
US7314636B2 (en) 2001-06-29 2008-01-01 Medgraft Microtech, Inc. Biodegradable injectable implants containing glycolic acid
FR2850282A1 (fr) * 2003-01-27 2004-07-30 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
US9144631B2 (en) 2003-01-27 2015-09-29 Benedicte Asius Ceramic-based injectable implants which are used to fill wrinkles, cutaneous depressions and scars, and preparation method thereof
WO2009014441A2 (en) 2007-07-26 2009-01-29 Aqtis Ip Bv Microparticles comprising pcl and uses thereof
US8795694B2 (en) 2007-07-26 2014-08-05 Aqtis I.P. B.V. Microparticles comprising PCL and uses thereof
WO2018219987A1 (en) 2017-05-30 2018-12-06 Aqpha Ip B.V. Resorbable biodegradable medical and cosmetic composition comprising poly(1,3-trimethylene carbonate)
US11331411B2 (en) 2017-05-30 2022-05-17 Aqpha Ip B.V. Resorbable biodegradable medical and cosmetic composition comprising poly(1,3-trimethylene carbonate)

Also Published As

Publication number Publication date
BR9804962A (pt) 1999-09-08
DK0969883T3 (da) 2004-03-01
US20120231046A1 (en) 2012-09-13
DE69819694D1 (de) 2003-12-18
HK1025268A1 (en) 2000-11-10
RO118261B1 (ro) 2003-04-30
TR199900297T1 (xx) 1999-09-21
HUP0001465A2 (hu) 2000-10-28
FR2764514B1 (fr) 1999-09-03
PT969883E (pt) 2004-04-30
CA2263361C (fr) 2006-10-24
US7731758B2 (en) 2010-06-08
IL128210A0 (en) 1999-11-30
JP2000516839A (ja) 2000-12-19
ES2210776T3 (es) 2004-07-01
KR20000068167A (ko) 2000-11-25
ATE253947T1 (de) 2003-11-15
RU2214283C2 (ru) 2003-10-20
AU8218298A (en) 1998-12-30
CA2263361A1 (fr) 1998-12-17
DE69819694T2 (de) 2004-09-30
IL128210A (en) 2004-02-19
PL331703A1 (en) 1999-08-02
EP0969883B1 (fr) 2003-11-12
FR2764514A1 (fr) 1998-12-18
US20100221684A1 (en) 2010-09-02
HU228462B1 (en) 2013-03-28
HUP0001465A3 (en) 2001-11-28
US6716251B1 (en) 2004-04-06
KR100543560B1 (ko) 2006-01-20
AU744366B2 (en) 2002-02-21
US20040191323A1 (en) 2004-09-30
EP0969883A1 (fr) 2000-01-12
US8414657B2 (en) 2013-04-09

Similar Documents

Publication Publication Date Title
EP0969883B1 (fr) Implant injectable par voie sous-cutanee ou intradermique
EP1404294B1 (en) Biodegradable polymer composition
JP3351525B2 (ja) 骨形成性蛋白医薬処方物
US5945115A (en) Polymeric compositions useful as controlled release implants
JP2685353B2 (ja) 歯周組織の再生のための生体分解系
KR20040048382A (ko) 생분해성 주사가능한 이식제 및 관련된 제조방법과 용도
EP1587556B1 (fr) Implants injectables a base de ceramique pour le comblement de tissus mous
WO2019139380A1 (ko) 비타민 c가 함유된 폴리카프로락톤 미립구 필러 및 그 제조방법
Ma et al. A composited PEG-silk hydrogel combining with polymeric particles delivering rhBMP-2 for bone regeneration
FR2955258A1 (fr) Composition injectable
EP0621776B1 (fr) Composition injectable contenant des microcapsules de collagene
HK1025268B (en) Implant for subcutaneous or intradermal injection

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1998932196

Country of ref document: EP

Ref document number: 82182/98

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 99-00141

Country of ref document: RO

Ref document number: 09242103

Country of ref document: US

ENP Entry into the national phase

Ref document number: 2263361

Country of ref document: CA

Ref document number: 2263361

Country of ref document: CA

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 1999 501805

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1999/00297

Country of ref document: TR

WWE Wipo information: entry into national phase

Ref document number: 1019997001267

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: PA/a/1999/001569

Country of ref document: MX

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1998932196

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1019997001267

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 82182/98

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 1998932196

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1019997001267

Country of ref document: KR