US9173766B2 - Systems and methods to treat upper pharyngeal airway of obstructive sleep apnea patients - Google Patents

Systems and methods to treat upper pharyngeal airway of obstructive sleep apnea patients Download PDF

Info

Publication number
US9173766B2
US9173766B2 US13486293 US201213486293A US9173766B2 US 9173766 B2 US9173766 B2 US 9173766B2 US 13486293 US13486293 US 13486293 US 201213486293 A US201213486293 A US 201213486293A US 9173766 B2 US9173766 B2 US 9173766B2
Authority
US
Grant status
Grant
Patent type
Prior art keywords
filament
palatopharyngeal
muscle
device
method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US13486293
Other versions
US20130319427A1 (en )
Inventor
An-Min Jason Sung
Robert A. Rousseau
David C. Lindh, SR.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethicon Inc
Original Assignee
Ethicon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/56Devices for preventing snoring
    • A61F5/566Intra-oral devices

Abstract

Obstructive Sleep Apnea (OSA) may be caused by a collapse of the pharyngeal wall as a result of increasing negative airway pressure. This invention is directed to systems and methods to resist collapse of the pharyngeal wall by minimally invasive upper pharyngeal airway surgery.

Description

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention generally relates to systems and methods to treat obstructive sleep apnea (OSA), more particularly to minimally invasive solutions to prevent collapse of the upper pharyngeal airway.

2. Related Art

OSA is caused by a blockage of the airway, which usually occurs when the soft tissue in the throat collapses and closes during sleep. According to the National Institutes of Health, OSA affects more than twelve million Americans. During each apnea event, the brain briefly arouses the sufferer in order to initiate the resumption of breathing. This type of sleep, however, is extremely fragmented and of poor quality. When left untreated, OSA may result in high blood pressure, cardiovascular disease, weight gain, impotency, headaches, memory problems, job impairment, and motor vehicle crashes. Despite the seriousness of OSA, a general lack of awareness among the public and healthcare professionals results in the vast majority of OSA sufferers remaining undiagnosed and untreated.

One non-surgical method available to treat OSA, commonly referred to as continuous positive airway pressure (CPAP), delivers air into a patient's airway through a specially designed nasal mask or pillow. The flow of air creates positive pressure when the patient inhales to keep the airway open. CPAP is considered by many to be an effective non-surgical treatment for the alleviation of snoring and obstructive sleep apnea, however, patients complain about discomfort caused by the mask and hoses, including bloating, nasal drying, and dry eyes. As a result, patient compliance for CPAP is only about 40%.

Surgical treatments have also been used to treat OSA. One such treatment is referred to as uvulopalatopharyngoplasty, which involves removing about 2 cm of the trailing edge of the soft palate to reduce the soft palate's ability to flutter between the tongue and the pharyngeal wall. Another procedure uses a surgical laser to create scar tissue on the surface of the soft palate, which reduces the flexibility of the soft palate for reducing snoring and/or closing of the air passage. Yet another procedure, commonly referred to as cautery-assisted palatal stiffening operation (CAPSO), is an office-based procedure performed under local anesthesia whereby a midline strip of soft palate mucosa is removed, and the wound is allowed to heal whereupon the flaccid palate is stiffened.

Surgical procedures such as those mentioned above continue to have challenges. More specifically, the area of tissue that is surgically treated (i.e., removal of palatal tissue or scarring of palatal tissue) is often larger than is necessary to treat the patient's condition. In addition, the above-mentioned surgical procedures are often painful with extended, uncomfortable healing periods. For example, scar tissue on the soft palate may be a cause of continuing irritation to the patient. Furthermore, the above procedures are not reversible in the event of adverse side effects.

Another implant system, sold under the trademark REPOSE™ by InfluENT of Concord, N.H., uses a titanium screw that is inserted into the posterior aspect of the mandible at the floor of the mouth. The screw acts as an anchor. A loop of suture is passed through the tongue base and attached to the mandibular bone screw. The REPOSE™ procedure achieves a suspension or hammock of the tongue base making it less likely for the base of the tongue to prolapse into the patient's airway during sleep. Due to the high activity of the tongue during wakefulness, however, the suture component of this device may act as a cutting element within the tongue, causing device trans-location and ultimately a loss of efficacy of the procedure thereby requiring subsequent removal.

An additional tongue suspension device developed by ASPIRE Medical is named the ADVANCE System. It is similar to the REPOSE suture suspension system for the tongue base in that it utilizes a bone screw in the mandible as an anchor, but has the advantage of being adjustable. The device further utilizes a flexible shape memory soft tissue anchor within the tongue that is shaped similar to a grappling hook, to engage the tissue within the tongue base. The soft tissue anchor is placed through a small incision in the submental region of the patient's head and the suture is attached to a spool-like component attached to the mandible. Two to four weeks after healing, a small incision is made under the chin and a screw is turned to tighten the suture, thus pulling the device forward. While the device provides a simplified installation technique from within the sterile space, the anchors may suffer from device fracture and failure due to loading within the tongue musculature.

A further system is disclosed in US 2008/0208265, Frazier, et al., entitled “System and Method for Percutaneous Palate Remodeling.” This publication discloses a looped tether element with one or more regions of an expanded diameter to reduce the risk of cutting through the tongue. This region is created to provide a flexible implant with a fixed expanded region, a balloon region or an in-situ expanding region. This method provides a large bearing surface on limited regions of the fiber. Additionally, this method requires a supplemental element to create the expanded region on the fiber. It is anticipated that this type of device will also be difficult to extract from tongue tissues after healing has occurred since the portion buried on the tongue base is larger in cross section than the tracks remaining from the trailing ends of the looped tether.

In spite of the above advances in OSA treatment, there remains a need for devices, systems and methods for treating OSA through minimally invasive approaches that will improve long term results with improved patient compliance and minimized patient discomfort.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 depicts a frontal view of tissues in the oral cavity and oropharynx prior to the tensioning of a device to enlarge the airway.

FIG. 2 shows a frontal view of tissues in the oropharynx after the tensioning of a device that enlarges the airway.

FIG. 3 is an oblique view of FIG. 1.

FIG. 4 is an oblique view of FIG. 2.

FIG. 5 is a posterior-lateral view of FIG. 1.

FIG. 6 is a posterior-lateral view of FIG. 2.

FIGS. 7 a-c depict various forms of a device useful in this invention.

FIGS. 8 a and 8 b depict alternate devices useful in this invention.

SUMMARY OF THE INVENTION

One aspect of this invention relates to a method of supporting or reshaping a targeted tissue with a device, wherein the device comprises a central load bearing section having a first end and a second end, a first filament section having a first free end and a second end connected to the first end of the load bearing section, and a second filament section having a first free end and a second end connected to the second end of the load bearing section comprising the steps of:

    • a) passing the free end of the first filament section in a first direction leaving the load bearing section around the targeted tissue and into a first supporting tissue;
    • b) passing the free end of the second filament section into tissue in a different direction from the first direction and into a second supporting tissue while maintaining the load bearing section around the targeted tissue; and
    • c) applying tension to the free ends of the first and second filament sections to sufficiently support or reshape the targeted tissue.

In a preferred embodiment the first supporting tissue structure is the palatoglossal muscle, the second supporting tissue structure is the upper portion of the palatopharyngeal, and the tissue structure being supported or reshaped is the lower portion of the palatopharyngeus muscle (also referred to as the posterior pillar). In certain further embodiments neighboring muscular structures to the palatoglossal muscle and the palatopharyngeal muscle may be used as further supporting structures. One such additional muscle is the pharyngeal constrictor muscle.

Another aspect of this invention generally relates to a method of increasing the patency of an airway of a patient comprising the step of retracting or supporting one or both of the palatopharyngeal muscles.

Other embodiments of this invention relate to tissue support devices comprising:

    • a) a central load bearing section having a first end and a second end;
    • b) a first filament section having a first end and a second end with the first end connected to the first end of the load bearing section;
    • c) a second filament section having a first end and a second end with the first end connected to the second end of the load bearing section; and
      wherein the first filament section comprises barbs.

Alternate embodiments of the foregoing are hereinafter disclosed including kits and systems that incorporate the various components needed to perform the methods of this invention.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS OF THE INVENTION

This invention discloses systems and methods using a device to retract, support or reshape soft tissue. Preferably, the device has barbed sections to hold the device in supporting tissue in a desired location and it is used to enlarge the air pathway in the oropharynx of a patient. More specifically, this invention relates to methods of increasing the patency of an airway of a patient comprising the step of retracting or supporting one or both of the palatopharyngeal muscles.

In treating the conditions of obstructive sleep apnea (and snoring due to partially obstructed airways), it is useful to understand the basic anatomy of the airway being treated and such discussion is hereinafter provided.

FIG. 1 depicts some of the major features and the boundaries of the oral cavity and the oropharnyx.

For purposes of this invention, the oral cavity proper is bounded: superiorly by the hard palate 1 and soft palate 2; inferiorly by the tongue 3 and the floor of the mouth; antero-laterally by the upper and lower teeth 4; and posteriorly by the palatoglossal arch 40.

As used herein, the palatoglossal arch is intended to describe the mucosal membrane folds that enclose the palatoglossal muscles. The palatoglossal arch is on either side of the oropharynx (and actually divides the oral cavity from the oropharynx) and is anterior to the palatopharyngeal arch. The palatopharyngeal arch is intended to describe the mucosal membrane folds that enclose the palatopharyngeal muscles on either side of the oropharynx.

The oropharynx or upper pharyngeal area as used herein is meant to describe the location of the anatomy bounded: superiorly by the soft palate 2; inferiorly by the upper border of the epiglottis and root of the tongue 3 and located posterior to the palatoglossal arch 40; and by posterior and lateral walls formed by the superior pharyngeal constrictor muscles 50 (see FIGS. 5 and 6) and middle pharyngeal constrictor muscles. Referring again to FIG. 1, the oropharynx contains tonsils 20 and the palatopharyngeal arch 30.

In preferred embodiments according to this invention, tissue in the oropharynx is targeted for retraction, support or reshaping to increase the patency of the airway.

FIG. 2 shows a preferred embodiment where soft tissue in the oropharynx is retracted to increase the patency of the airway. Generally, device 10, preferably barbed, is placed in a specific location to achieve multi-vector retraction of tissue within the oropharynx. In this instance, device 10 contains a load bearing section 12 which is placed submucosally around the palatopharyngeal muscles 30. This placement of device 10 avoids “strangulation” of the tissue and a generally follows a helical path around palatopharyngeal muscle 30. The ends of device 10 are then pulled to retract, support, and/or reshape the palatopharyngeal arch. Desirably, placement and tension of the ends of the device provide multi-vector displacement of the palatopharyngeal arch which includes 1) midline to lateral; 2) dorsal to ventral; and 3) inferior to superior retraction. This retraction of tissue results in multidirectional expansion in the following vectors: 1) lateral-to-lateral; 2) posterior to anterior (i.e., from the arch toward mandible); and 3) inferior-to-superior (i.e., from palatine arch to the hard palate/upper maxilla), thus enlarging the airway. When comparing FIG. 1 to FIG. 2, one notices airway enlargement as illustrated by the lateral-lateral expansion X′ in FIG. 2 being increased when compared to the lateral pretreatment distance X of FIG. 1.

FIGS. 3 and 4 provide oblique views of FIGS. 1 and 2, respectively. In particular, FIG. 3 shows implantation of device 10 around palatopharyngeal muscle 30 prior to tensioning of device 10. FIG. 4 depicts palatopharyngeal muscles 30 after tensioning of device 10 wherein palatopharyngeal muscles 30 are displaced forward toward, upward and adjacent to palatoglossal muscles 40. Note that in these figures, tonsil 20 has been previously removed.

FIGS. 5 and 6 show posterior-lateral views of FIGS. 1 and 2, respectively with the addition of pharyngeal constrictor muscle 50. In particular, FIG. 5 shows implantation of device 10 around palatopharyngeal muscles 30 prior to tensioning of device 10 with tonsil 20 in place. FIG. 6 depicts palatopharyngeal arch 30 after tensioning of device 10 and removal of tonsil 20 wherein palatopharyngeal muscles 30 is displaced forward toward, upward and adjacent to palatoglossal muscles 40. FIGS. 5 and 6 also show the anchoring of device 10 in pharyngeal constrictor muscle 50.

FIGS. 7 a-c describe various embodiments of device 10. In particular, FIG. 7 a shows device 10 with load supporting member 12 and barbs 14 on both sides of member 12 with filaments 18 ending at tapered tips 16. Desirably, the barbs are fashioned to be bidirectional as shown in FIG. 7 a. FIG. 7 b shows an alternate embodiment with only one of the filaments 18 of device 10 having barbs 14. Finally, FIG. 7 c shows device 10 with support member 12 but with filaments 18 containing no barbs. The embodiments of FIG. 7 b and FIG. 7 c which have barbless sections would be useful in situations where another anchoring location or anchoring means are used rather than using barbed filaments for anchoring in tissue. Thus, this invention contemplates devices 10 that may comprise barbs on both filaments, on one filament or on no filaments of the device.

FIGS. 8 a and 8 b provide alternate designs for device 10 when the intermediate supporting structure 12 is not desired or needed. Referring to these figures, device 10 comprises filament 18 which may be barbed (element 14 in FIG. 8 a) or not barbed (as depicted in FIG. 8 b). The distal tapered tips 16 are the same as described above. The proximal tab 19 has a tissue facing surface “A” and a thickness “t” and is designed as a low profile stop which prevents device 10 from passing completely through the tissue targeted to be treated. Desirably, the low profile tab thickness ranges from 0.005 to 0.050 inches and wherein the ratio of tissue facing surface area to thickness ranges from 0.01 to 5. While tab 19 is depicted as a circular element, tab 19 may be of a variety of shapes that function to stop device 10 from completely passing through the tissue targeted to be treated and which is conformable with the targeted tissue (i.e., tab 19 has a low profile so as not to project and interfere with tissue adjacent to the targeted tissue and which achieves the goal of the treatment such as increased airway patency of the oropharynx). Examples of additional suitable shapes for tab 19 include but are not limited to flat, planar shapes and elliptical shapes.

Device 10 of FIGS. 8 a and 8 b are most useful when only a targeted retraction of tissue is desired. For example, device may be passed through the desired tissue with tissue retraction being concentrated where the tab interfaces with the tissue that has been targeted to be treated. While not forming any device claims to this invention, alternative devices useful with the methods of this invention are found in US2005/0267531. This publication provides alternative barbed filament devices that include various tab or “anchor” designs that may also anchor in tissue such as depicted in FIGS. 39 A and 39 B in contrast to the devices 10 depicted in FIGS. 8 a and 8 b of this invention.

Ends 16 of device 10 may also have attached to it one or more needles. Preferably, the needle tips are tapered and end in a point. Additionally a needle attached to one end of the device need not be the same size as a needle attached to the other end of the device. The selection of size and type of needle would be determined by one of skill of the art and designed for the requirements of the specific application the device is being used for.

The distinct sections of device 10 are designed for different and separate functionalities. For example, the load bearing section 12 is the center broader section that will eventually be implanted under a mucosal layer. The load bearing section 12 serves as a brace during tensioning/lifting the tissue without cutting through tissue. Preferably, both filaments 18 extending from section 12 of the device are barbed and serve to support and reposition the tissue. Preferably, the barbs 14 can collapse during insertion to reduce insertion drag as well as reduce damage to tissue. The lead ends 16 of filaments 18 are desirably clear, tapered, and without barbs. These ends are tapered to reduce the sensation in the patient's mouth during implantation. Line markers (e.g., graduations) may be placed on lead ends 16 of filaments to indicate displacement or depth of placement peri-operatively or post-operatively. The markers may be visible (e.g., colored) or radio-opaque. The load bearing section 12 may also have visible or radio-opaque markers. Load bearing section 12 may be of a variety of shapes that functions support the tissue targeted to be treated and which is conformable with the targeted tissue (i.e., has a low profile so as not to project and interfere with tissue adjacent to the targeted tissue and which achieves the goal of the treatment such as increased airway patency of the oropharynx). Examples of suitable shapes for load bearing section 12 include but are not limited to oblong, rectangular, circular and elliptical.

Barbs 14 of device 10 may be of any of a variety of designs and are intended to grasp and anchor themselves in tissue to maintain the desired position for device 10. Barbs 14 can be a series of protruding elements either molded on to the filament 18 such as disclosed in U.S. Pat. No. 4,069,865 and U.S. Pat. No. 5,123,913 or added as separate components on to filament 18 as disclosed in US2006/0079935. Barbs 14 can also be cuts created with blades along filament 18 as disclosed in U.S. Pat. No. 3,123,007 and US2007/0005109. In other instances, barbs 14 along with filament 18 can be die cut as disclosed in US 2003/0149447 and U.S. Pat. No. 7,850,894. Furthermore, the barbs on one filament may be different from the barbs on the other filament and the length of the barbed sections may be of different length. The barbs may also be asymmetrically located with respect to the load bearing section and multiple and different barb geometries may be present on one device (e.g., possibly larger with a shorter barbed section). The various embodiments of the device will depend on the desired tissue being treated and the manner in which the device will be anchored.

Device 10 may be made of many biocompatible materials. Examples of suitable materials include but are not limited to non-absorbable materials such as polyamides (e.g., polyhexamethylene adipamide (nylon 66), polyhexamethylene sebacamide (nylon 610), polycapramide (nylon 6), polydodecanamide (nylon 12) and polyhexamethylene isophthalamide (nylon 61) copolymers and blends thereof), polyesters (e.g., polyethylene terephthalate, polybutyl terephthalate, copolymers and blends thereof), fluoropolymers (e.g., polytetrafluoroethylene and polyvinylidene fluoride) Poly (hexafluoropropylene -VDF), polyaryletherketones, polyolefins (e.g., polypropylene including isotactic and syndiotactic polypropylene and blends thereof, as well as, blends composed predominately of isotactic or syndiotactic polypropylene blended with heterotactic polypropylene and/or polyethylene (such as is described in U.S. Pat. No. 4,557,264, assigned to Ethicon, Inc., hereby incorporated by reference in its entirety)) and combinations thereof.

Additionally, bioabsorbable materials may be used in this invention either alone or in combination with the non-absorbable biocompatible material described above. In the case that a fully bioabsorbable material is used, the application that this material is used would most likely be one in which a temporary retraction or support of tissue is desired and that once the absorbable material is absorbed, the supported tissue would return to its natural tone. Suitable bioabsorbable materials for use in this invention include, but are not limited to, aliphatic polyesters which include but are not limited to homopolymers and copolymers of lactide (which includes lactic acid, d-,l- and meso lactide), glycolide (including glycolic acid), ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate (1,3-dioxan-2-one), alkyl derivatives of trimethylene carbonate, δ-valerolactone, β-butyrolactone, γ-butyrolactone, ε-decalactone, hydroxybutyrate, hydroxyvalerate, 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclotetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one and polymer blends thereof.

Combinations of absorbable and non-absorbable materials may also be utilized to produce a device with tailored properties and configurations. One such configuration contemplated is one which provides devices with absorbable coverings obtained through processing such as by coating and/or co-extrusion.

The selection of the materials for use in the device would be determined by one of the skill of the art and designed for the requirements of the specific application. The most preferred materials are non-absorbable for at least one component for long term efficacy in enabling the supported tissue to remain in the orientation achieved during implantation. Thus of the foregoing materials, the preferred device materials are polyesters (e.g. polyethylene terephthalate, polybutyl terephthalate, copolymers and blends thereof), fluoropolymers (e.g. polytetrafluoroethylene and polyvinylidene fluoride) Poly (hexafluoropropylene -VDF), polyaryletherketones, polyolefins (e.g. polypropylene including isotactic and syndiotactic polypropylene). The most preferred materials are poly (hexafluoropropylene -VDF) and polypropylene.

To achieve increased patency of the airway described in the forgoing discussion, two methods of delivery of the device are contemplated. The first described method is for using a bidirectional device such as depicted in FIGS. 7 a-7 c, i.e., for those devices which have a load bearing or support portion. The second method described may be used for the bidirectional devices of FIGS. 7 a-7 c, i.e., for those devices which have a load bearing or support portion and for the case of unidirectional devices such as depicted in FIGS. 8 a and 8 b or described in US2005/0267531 devices. For either method, the tonsils may or may not be present. Most preferably, however, removal of the tonsils is desirable as this will provide more room for retraction, for example, of the palatopharyngeal arch.

The first method for the delivery of the support device is through the use of needles. The technique generally involves inserting the device with a needle attached to one or both ends of the device from the back of the mouth and into the oropharynx area and driving the needle(s) forward following the pathway of the method described below. One important feature for these needles is to have a curvature and chord depth that enables passage through tissue at a depth of about 2 mm to less than about 2 cm and having an entry and exit points between about 0.5 and 3 inches to avoid deep penetration during placement, thus minimizing the potential of damaging critical structures like the internal carotid artery. Additionally use of short needles may be desired to create an undulating path that would result with the load of supporting the targeted tissue being distributed along a path of multiple force vectors.

More specifically the method comprises the steps of:

    • a) removing the tonsils, if needed, if not, creating an incision through the mucosal layer at the medial aspect of the palatopharyngeal fold;
    • b) inserting a first needle attached to the first end of the device having a central load bearing section and a first filament end and a second filament end extending from either end of the central load bearing section around or into the medial aspect of the palatopharyngeal muscle within the incision;
    • c) passing the first needle at the first entry point through the palatoglossal muscle and directing the needle between the mucosa and pharyngeal constrictor muscle or within the pharyngeal constrictor muscle caudal to the last molar and exit at the first exit point;
    • d) inserting a second needle into the medial aspect of the palatopharyngeal muscle within the incision slightly lateral and superior to the insertion point of the first needle at a second entry point;
    • e) passing the second needle around or through the palatopharyngeal muscle and directing the needle through tissue between the palatopharyngeal and superior pharyngeal constrictor muscles or within palatopharyngeal muscle toward the hard palate and exit at the second exit point;
    • f) pulling both ends of the device that are attached to the first needle and second needle until the center load support section is nesting at the apex of the palatopharyngeal muscle;
    • g) pulling the filament ends of the device at the same time or individually to adjust the tension/displacement of the palatopharyngeal muscle to increase the patency of the airway; and
    • h) trimming the excess of the filament ends of the device or allowing the ends to remain under the mucosa.
      The above method desirably is repeated for treatment of the palatopharyngeal arch on the opposite side of the oropharynx.

The extent that the airway patency is improved may be determined by taking the following measurements and comparing these measurements to measurements taken prior to treatment:

    • i) Lateral—lateral aspect: Distance between the palatopharyngeal arches;
    • ii) Vertical opening (anterior-posterior): Distance between the uvula (or palatopharyngeal arches) and posterior pharyngeal wall; and
    • iii) Distance from the tip of uvula (or palatopharyngeal arches) to the hard palate.
      The second method is to use commonly available instruments such as a suture passer or a trocar system with a tube with a snare, going in from the front of the mouth following the pathway described in the first method above and pulling the device 10 through. The suture passer or trocar will however travels in a reverse direction of device 10 as described in the first method above.

Therefore entry of the trocar or suture passer is made from the exit points previous described and exit from the entry points previously described. The suture passer has a grasping end to engage with filament 18 to pull it through the pathway described above. The trocar system will have the snare engaging with filament 18 to pull it through the pathway described above. The design of suture passer or trocar desirably comprises a pre-shaped wire or tube configured to the desired angle that will give user the control to deliver the tissue support device according to the pathway described above. The suture passer or trocar is preferably made of steel or nitinol.

In the case of unidirectional devices such as depicted in FIGS. 8 a and 8 b or described in US2005/0267531, the method of increasing the patency of an airway of a patient comprises the step of retracting or supporting one or both of the palatopharyngeal muscles wherein the step of retracting or supporting the palatopharyngeal muscle(s) comprises:

    • a) piercing at least one of the palatopharyngeal muscles with a device comprising a filament extending from a tab wherein the filament end of the device pierces at least one of the palatopharyngeal muscles;
    • b) drawing the filament end of the device through the at least one palatopharyngeal muscle until the tab rests at the point where the palatopharyngeal muscle had been pierced; and
    • c) applying tension to the filament end of the device to retract or support the at least one of the palatopharyngeal muscles.

In preferred embodiments the filament is barbed, and desirably two devices each comprising a barbed filament and tab both pierce at least one of the palatopharyngeal muscles and the filament end of one of the devices anchors in the palatoglossal muscle and the filament end of the second of the devices anchors in the palatopharyngeal muscle.

This invention further contemplates kits or systems that provide the various components needed to perform the forgoing described methods. For example, the system or kit may comprise the device 10 in various sizes and include needles attached to the filament ends of the device in a variety of sizes and shapes. Additionally the system or kit may contain the tissue support device fitted with needles of various shapes and sizes. A suture passer, sized to deliver the tissues support design and optionally a trocar may be provided.

It should be understood that the foregoing disclosure and description of the present invention are illustrative and explanatory thereof and various changes in the size, shape and materials as well as in the description of the preferred embodiments may be made without departing from the spirit of the invention.

Claims (10)

What is claimed is:
1. A method for supporting or reshaping a palatopharyngeal muscle with a device, wherein the device comprises a central load bearing section having a first end and a second end, a first filament section having a first free end and a second end connected to the first end of the load bearing section, and a second filament section having a first free end and a second end connected to the second end of the load bearing section comprising the steps of:
a) passing the free end of the first filament section in a first direction leaving the load bearing section around the palatopharyngeal muscle and into a first supporting tissue;
b) passing the free end of the second filament section into tissue in a different direction from the first direction and into a second supporting tissue while maintaining the load bearing section around the palatopharyngeal muscle wherein the passing of the filaments follow a helical path; and
c) applying tension to the free ends of the first and second filament sections to sufficiently support or reshape the palatopharyngeal muscle to achieve multi-vector retraction.
2. The method of claim 1 wherein the first supporting tissue is the palatoglossal muscle and neighboring muscular structures and the second supporting tissue is the palatopharyngeal muscle and neighboring muscular structures including a superior pharyngeal constrictor muscle.
3. The method of claim 2 wherein the applied tension to the free ends of the filaments results in the palatopharyngeal muscle being retracted toward the palatoglossal muscle.
4. The method of claim 3 wherein the first filament section contains barbs.
5. The method of claim 4 wherein both the first and second filament sections contain barbs.
6. The method of claim 5 wherein the barbs of the first filament section are oriented in a direction opposite to an orientation of the barbs of the second filament section.
7. The method of claim 3 wherein the second filament section contains barbs.
8. A method for increasing a patency of an airway of a patient, the airway comprising palatopharyngeal muscles and palatoglossal muscles, the method comprising the step of retracting or supporting one or both of the palatopharyngeal muscles, wherein the step of retracting or supporting the palatopharyngeal muscle(s) comprises:
a) piercing at least one of the palatopharyngeal muscles at a point with a device comprising a filament extending from a tab wherein the filament pierces at least one of the palatopharyngeal muscles;
b) drawing the filament through the at least one palatopharyngeal muscle until the tab rests at the point where the palatopharyngeal muscle had been pierced wherein the drawing of the filament follows a helical path; and
c) applying tension to the filament to retract or support the at least one of the palatopharyngeal muscles.
9. The method of claim 8 where the filament is barbed.
10. The method of claim 9 wherein a first device and a second device each comprising a barbed filament and tab both pierce at least one of the palatopharyngeal muscles and the filament first device anchors in the palatoglossal muscle and the filament of the second device anchors in the palatopharyngeal muscle.
US13486293 2012-06-01 2012-06-01 Systems and methods to treat upper pharyngeal airway of obstructive sleep apnea patients Active 2034-01-08 US9173766B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13486293 US9173766B2 (en) 2012-06-01 2012-06-01 Systems and methods to treat upper pharyngeal airway of obstructive sleep apnea patients

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13486293 US9173766B2 (en) 2012-06-01 2012-06-01 Systems and methods to treat upper pharyngeal airway of obstructive sleep apnea patients
PCT/US2013/043238 WO2013181327A1 (en) 2012-06-01 2013-05-30 Systems to treat upper pharyngeal airway of obstructive sleep apnea patients

Publications (2)

Publication Number Publication Date
US20130319427A1 true US20130319427A1 (en) 2013-12-05
US9173766B2 true US9173766B2 (en) 2015-11-03

Family

ID=48741477

Family Applications (1)

Application Number Title Priority Date Filing Date
US13486293 Active 2034-01-08 US9173766B2 (en) 2012-06-01 2012-06-01 Systems and methods to treat upper pharyngeal airway of obstructive sleep apnea patients

Country Status (2)

Country Link
US (1) US9173766B2 (en)
WO (1) WO2013181327A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8413661B2 (en) 2008-08-14 2013-04-09 Ethicon, Inc. Methods and devices for treatment of obstructive sleep apnea
US8783258B2 (en) * 2008-12-01 2014-07-22 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US8800567B2 (en) 2008-12-01 2014-08-12 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US8371308B2 (en) * 2009-02-17 2013-02-12 Ethicon, Inc. Magnetic implants and methods for treating an oropharyngeal condition
US9326886B2 (en) * 2009-10-29 2016-05-03 Ethicon, Inc. Fluid filled implants for treating obstructive sleep apnea
US9877862B2 (en) 2009-10-29 2018-01-30 Ethicon, Inc. Tongue suspension system with hyoid-extender for treating obstructive sleep apnea
US9974683B2 (en) 2009-10-30 2018-05-22 Ethicon, Inc. Flexible implants having internal volume shifting capabilities for treating obstructive sleep apnea
US8905033B2 (en) 2011-09-28 2014-12-09 Ethicon, Inc. Modular tissue securement systems
US9161855B2 (en) 2011-10-24 2015-10-20 Ethicon, Inc. Tissue supporting device and method
US8973582B2 (en) 2011-11-30 2015-03-10 Ethicon, Inc. Tongue suspension device and method
US9173766B2 (en) 2012-06-01 2015-11-03 Ethicon, Inc. Systems and methods to treat upper pharyngeal airway of obstructive sleep apnea patients
US9439801B2 (en) 2012-06-29 2016-09-13 Revent Medical, Inc. Systems and methods for treatment of sleep apnea
WO2018063183A1 (en) * 2016-09-28 2018-04-05 Oday John M Nasopharyngeal device for obstructive sleep apnea syndrome

Citations (217)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2705492A (en) 1953-04-06 1955-04-05 Milton H Chandler Teeth protector
US3123007A (en) 1964-03-03 Well pump
US3378010A (en) 1965-07-28 1968-04-16 Coldling Surgical clip with means for releasing the clamping pressure
US4024855A (en) 1974-12-30 1977-05-24 Louis Bucalo Magnetic filamentary structure and method for using the same
US4069865A (en) 1975-09-12 1978-01-24 Otis Engineering Corporation Bottom hole fluid pressure communicating probe and locking mandrel
US4290763A (en) 1979-06-15 1981-09-22 Hurst Gerald L Method for producing enclosed multipaneled envelopes
SU927236A1
US4523584A (en) 1983-03-04 1985-06-18 Medical Engineering Corporation Penile erectile system
US4557264A (en) 1984-04-09 1985-12-10 Ethicon Inc. Surgical filament from polypropylene blended with polyethylene
US4839215A (en) 1986-06-09 1989-06-13 Ceramed Corporation Biocompatible particles and cloth-like article made therefrom
US4881939A (en) 1985-02-19 1989-11-21 The Johns Hopkins University Implantable helical cuff
US4950285A (en) 1989-11-27 1990-08-21 Wilk Peter J Suture device
FR2651113A1 (en) 1989-08-30 1991-03-01 Gilbert Alain Device for suturing a wound in an organ, such as a blood vessel
US5053047A (en) 1989-05-16 1991-10-01 Inbae Yoon Suture devices particularly useful in endoscopic surgery and methods of suturing
US5067485A (en) 1990-05-14 1991-11-26 Mentor Corporation Corpus cavernosum implant device
SU1697792A1
US5123913A (en) 1989-11-27 1992-06-23 Wilk Peter J Suture device
US5192271A (en) 1991-11-25 1993-03-09 Kalb Irvin M Device and method for effecting an erection
US5192274A (en) 1991-05-08 1993-03-09 Bierman Steven F Anchor pad for catheterization system
US5269783A (en) 1991-05-13 1993-12-14 United States Surgical Corporation Device and method for repairing torn tissue
RU2005447C1 (en) 1992-08-18 1994-01-15 Товарищество с ограниченной ответственностью - Акционерное общество закрытого типа Бюро "Денди" Snoring suppressor
US5284161A (en) 1992-11-12 1994-02-08 Karell Manuel L Snopper-the snoring stopper anti-snoring mouth device
US5311028A (en) 1990-08-29 1994-05-10 Nissin Electric Co., Ltd. System and method for producing oscillating magnetic fields in working gaps useful for irradiating a surface with atomic and molecular ions
US5484444A (en) 1992-10-31 1996-01-16 Schneider (Europe) A.G. Device for the implantation of self-expanding endoprostheses
US5485444A (en) 1991-06-07 1996-01-16 Deustsche Thomson-Brandt Gmbh Signalization of types of defects of an optical information carrier
US5609559A (en) 1995-05-15 1997-03-11 Weitzner; Howard B. Device for female patients to prevent involuntary loss of urine
WO1997013465A1 (en) 1995-10-09 1997-04-17 Medscand Medical Ab Surgical instrument for treating female urinary incontinence
US5683417A (en) 1996-08-14 1997-11-04 Cooper; William I. Suture and method for endoscopic surgery
US5704895A (en) 1979-12-28 1998-01-06 American Medical Systems, Inc. Implantable penile prosthetic cylinder with inclusive fluid reservoir
US5792067A (en) 1995-11-21 1998-08-11 Karell; Manuel L. Apparatus and method for mitigating sleep and other disorders through electromuscular stimulation
US5843077A (en) 1994-06-24 1998-12-01 Somnus Medical Technologies, Inc. Minimally invasive apparatus for internal ablation of turbinates with surface cooling
WO1999000058A1 (en) 1997-06-26 1999-01-07 Influence Medical Technologies, Ltd. Improved methods and devices for the treatment of airway obstruction, sleep apnea and snoring
US5931855A (en) 1997-05-21 1999-08-03 Frank Hoffman Surgical methods using one-way suture
WO2000066050A1 (en) 1999-05-03 2000-11-09 Wolfgang Fege Pharynx side implant
US6161541A (en) 1998-06-09 2000-12-19 Influent Ltd. Hyoid expansion and suspension procedure
US6190401B1 (en) 1991-05-13 2001-02-20 United States Surgical Corporation Device for applying a meniscal staple
JP2001145646A (en) 1999-09-17 2001-05-29 Pi Medical Inc Embedding object and method for treating snore
US6241747B1 (en) 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US6250307B1 (en) 1999-09-17 2001-06-26 Pi Medical, Inc. Snoring treatment
US20010037133A1 (en) 1999-09-17 2001-11-01 Knudson Mark B. Braided palatal implant for snoring treatment
CN2465680Y (en) 2000-11-23 2001-12-19 张鹏 Corrector for sleep apnea syndrome
US6348156B1 (en) 1999-09-03 2002-02-19 Baxter International Inc. Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma
US6408851B1 (en) 1999-10-01 2002-06-25 Manuel L. Karell Method and device for holding a tongue in a forward position
US6431174B1 (en) 2000-08-10 2002-08-13 Pi Medical, Inc. Method and apparatus to treat conditions of the naso-pharyngeal area
US6457472B1 (en) 1996-12-12 2002-10-01 The Johns Hopkins University Method and apparatus for providing ventilatory support to a patient
WO2001021107A9 (en) 1999-09-22 2002-10-03 Impra Inc Prosthesis for abdominal aortic aneurysm repair
US20020144685A1 (en) 2001-04-02 2002-10-10 Ivanovich Bredov Vladimir Multipurpose device for preventing and treating snoring and sleep apnea and /or preventing gnashing of teeth
US20030004579A1 (en) 2001-06-28 2003-01-02 Ethicon, Inc. Hernia repair prosthesis and methods for making same
US20030034312A1 (en) 2000-03-16 2003-02-20 Peter Unger Method and apparatus for treatment of biological material
US6523542B2 (en) 1999-09-17 2003-02-25 Pi Medical, Inc. Snoring treatment implant and method
US6578580B2 (en) 1999-09-17 2003-06-17 Restore Medical, Inc. Needle with pre-loaded implant for snoring treatment
US6589549B2 (en) 2000-04-27 2003-07-08 Macromed, Incorporated Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
US6599310B2 (en) 2001-06-29 2003-07-29 Quill Medical, Inc. Suture method
US20030149447A1 (en) 2002-02-01 2003-08-07 Morency Steven David Barbed surgical suture
US20030149445A1 (en) 2002-02-04 2003-08-07 Pi Medical, Inc. Pharyngeal wall treatment
US20030149488A1 (en) 2002-02-04 2003-08-07 Metzger Anja K. Stiffening pharyngeal wall treatment
US20030176875A1 (en) 2002-03-07 2003-09-18 Anderson Kimberly A. Transobturator surgical articles and methods
JP2003265621A (en) 2002-03-14 2003-09-24 Univ Nihon Indwelling and collecting type stent for disease in sleep apnea syndrome
US6627600B2 (en) 2000-01-27 2003-09-30 Ardana Bioscience Limited Compressed microparticles for dry injection
US6634362B2 (en) 1999-09-17 2003-10-21 Restore Medical, Inc. Braided implant for snoring treatment
US6638284B1 (en) 1999-06-08 2003-10-28 Ethicon, Inc. Knitted surgical mesh
WO2003096928A1 (en) 2002-05-22 2003-11-27 Sofradim Production Suburethral support assembly for the treatment of female stress urinary incontinence
US20040020492A1 (en) 2002-05-02 2004-02-05 Dubrul William R. Upper airway device and method
US20040028676A1 (en) 2002-08-06 2004-02-12 Klein Dean A. Swallowing system tissue modifier
US20040044366A1 (en) 2002-08-27 2004-03-04 Bonutti Peter M. Apparatus and method for securing a suture
WO2004020492A1 (en) 2002-08-30 2004-03-11 Asahi Organic Chemicals Industry Co., Ltd. Process for producing phenolic novolak
US6716251B1 (en) 1997-06-13 2004-04-06 Aventis Pharmaceuticals Holdings, Inc. Implant for subcutaneous or intradermal injection
US20040102796A1 (en) 2002-11-19 2004-05-27 J. Donald Hill Conduit coupling devices and methods for employing such devices
US6755868B2 (en) 2002-03-22 2004-06-29 Ethicon, Inc. Hernia repair device
US20040139975A1 (en) 2002-09-06 2004-07-22 Apneon, Inc. Magnetic force devices, systems, and methods for resisting tissue collapse within the pharyngeal conduit
US20040144395A1 (en) 2002-08-02 2004-07-29 Evans Douglas G Self-anchoring sling and introducer system
US20040147811A1 (en) 2001-12-14 2004-07-29 Diederich Chris J Catheter based balloon for therapy modification and positioning of tissue
US20040149290A1 (en) 2002-09-06 2004-08-05 Apneon, Inc. Devices, systems, and methods to fixate tissue within the regions of body, such as the pharyngeal conduit
US20040153127A1 (en) 2003-01-15 2004-08-05 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern Californ Treatments for snoring using injectable neuromuscular stimulators
DE10245076B4 (en) 2002-09-27 2004-09-02 Karl-Heinz Bachmann Instruments and procedures for the surgical treatment of female urinary incontinence
US6800082B2 (en) 2001-10-19 2004-10-05 Ethicon, Inc. Absorbable mesh device
WO2004060311A3 (en) 2002-12-30 2004-11-18 Quiescence Medical Inc Apparatus and methods for treating sleep apnea
US20040231678A1 (en) 2000-12-20 2004-11-25 Eduardo Fierro Adjustable autofixing sling for treatment of urinary incontinence
WO2004021870A3 (en) 2002-09-06 2004-12-02 Apneon Inc Magnetic force devices, systems, and methods for resisting tissue collapse within the pharyngal conduit
WO2004103196A1 (en) 2003-05-26 2004-12-02 Anthony Francis Connell A differential tissue expander implant
WO2004016196A3 (en) 2002-08-14 2004-12-23 Boston Scient Ltd Systems, methods and devices relating to delivery of medical implants
WO2004021869A3 (en) 2002-09-06 2005-01-27 Apneon Inc Systems and methods for moving and/or restraining tissue in the upper respiratory system
US20050038472A1 (en) 2002-07-31 2005-02-17 Icon Interventional Systems, Inc. Sutures and surgical staples for anastamoses, wound closures, and surgical closures
US20050082452A1 (en) 2003-01-06 2005-04-21 Lutron Electronics Co., Inc. Roller shade mounting system
US20050092334A1 (en) 2003-10-31 2005-05-05 Restore Medical, Inc. Airway implant
US6899105B2 (en) 2003-09-19 2005-05-31 Restore Medical, Inc. Airway implant cartridge and kit
US20050115572A1 (en) 2002-10-04 2005-06-02 Brooks Stephen N. Electrically activated alteration of body tissue stiffness for breathing disorders
US20050126563A1 (en) 2003-12-15 2005-06-16 Van Der Burg Erik J. System and method for hyoidplasty
US20050159637A9 (en) 2002-09-06 2005-07-21 Apneon, Inc. Devices, systems, and methods to fixate tissue within the regions of body, such as the pharyngeal conduit
US20050165352A1 (en) 2004-01-23 2005-07-28 Scimed Life Systems, Inc. Stent delivery catheter
WO2005082452A1 (en) 2004-02-26 2005-09-09 Ira Sanders A method and device for the treatment of obstructive sleep apnea and snoring
US20050203576A1 (en) 2002-06-07 2005-09-15 Sulamanidze Marlen A Surgical thread "aptos for cosmetic surgery
US6955172B2 (en) 2002-09-06 2005-10-18 Apneon, Inc. Systems and methods for moving and/or restraining the tongue in the oral cavity
US20050267531A1 (en) 2004-05-14 2005-12-01 Ruff Gregory L Suture methods and devices
US20050267321A1 (en) 2004-06-01 2005-12-01 Shadduck John H Elastomeric magnetic nanocomposite biomedical devices
US20050267532A1 (en) 2004-04-07 2005-12-01 Wu Tze Liang W Surgical thread
US20050267571A1 (en) 2003-12-23 2005-12-01 Spence Paul A Tissue fastening systems and methods utilizing magnetic guidance
US20050279365A1 (en) 2004-06-18 2005-12-22 Armijo Dennis F Anti-snoring apparatus and method
WO2005122954A1 (en) 2004-06-14 2005-12-29 Boston Scientific Scimed, Inc. Systems, methods and devices relating to implantable supportive slings
US6981944B2 (en) 2003-07-07 2006-01-03 Ethicon, Inc. Implantable surgical mesh having a lubricious coating
US20060079935A1 (en) 2004-06-30 2006-04-13 Alwin Kolster Suture for wound closure, tissue approximation, tissue support, suspension and/or fixation
US20060083767A1 (en) 2003-02-27 2006-04-20 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
US20060093644A1 (en) 2004-08-20 2006-05-04 Gerhard Quelle Methods of administering microparticles combined with autologous body components
US7056331B2 (en) 2001-06-29 2006-06-06 Quill Medical, Inc. Suture method
WO2006072571A1 (en) 2005-01-04 2006-07-13 Klinikum Der Universität Regensburg Implant device for the non-pneumatic adjustable positioning of a human or animal body part
US20060150986A1 (en) 2004-12-15 2006-07-13 Aspire Medical, Inc. System and method for hyoidplasty
WO2005051292A3 (en) 2003-11-20 2006-07-13 Apneon Inc Devices systems, and methods to fixate tissue within the regions of the body, such as the pharyngeal conduit
US20060185673A1 (en) 2005-02-24 2006-08-24 Restore Medical, Inc. Combination sleep apnea treatment
US20060206197A1 (en) 2002-12-30 2006-09-14 Hesham Morsi Endovascular balloon graft
US20060207612A1 (en) 2005-02-08 2006-09-21 Jasper Jackson Tissue anchoring system for percutaneous glossoplasty
JP2006517115T5 (en) 2006-09-28
WO2006108145A1 (en) 2005-04-06 2006-10-12 Boston Scientific Scimed, Inc. Systems, devices, and methods for treating pelvic floor disorders
US20060228391A1 (en) 2004-07-12 2006-10-12 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
US20060241339A1 (en) 2005-02-23 2006-10-26 Cook Timothy C Method and apparatus for an adjustable implantable continence device
US7135189B2 (en) 2001-08-23 2006-11-14 Boston Scientific Scimed, Inc. Compositions and techniques for localized therapy
US20060266369A1 (en) 2005-05-27 2006-11-30 Prospex Medical Ii, Inc. Devices and methods for treating sleep disorders
US20060289015A1 (en) 2002-09-06 2006-12-28 Apneon, Inc. Magnetic devices, systems, and methods placed in or on a tongue
US20070005110A1 (en) 2005-06-29 2007-01-04 Collier John P Braided barbed suture
US20070000497A1 (en) 2002-09-06 2007-01-04 Apneon, Inc. Devices, systems, and methods using magnetic force systems in or on tissue
US20070005109A1 (en) 2005-06-29 2007-01-04 Popadiuk Nicholas M Barbed suture
US7166570B2 (en) 2003-11-10 2007-01-23 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20070102004A1 (en) 2002-09-06 2007-05-10 Apneon Inc. Systems and methods for moving and/or restraining tissue in the upper respiratory system
US20070102010A1 (en) 2005-10-07 2007-05-10 Lemperle Stefan M Naso-pharyngeal tissue engineering
US20070110788A1 (en) 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
WO2007056583A1 (en) 2005-11-09 2007-05-18 Aspire Medical, Inc. Glossoplasty using tissue anchor glossopexy with volumetric tongue reduction
US20070123996A1 (en) 2005-10-14 2007-05-31 Kiminobu Sugaya Stem cell comprising tissue substitutes
US20070144535A1 (en) 2004-09-21 2007-06-28 Hegde Anant V Implant for treatment of sleep disorders
US20070144531A1 (en) 2002-09-06 2007-06-28 Apneon, Inc. Device, systems and methods having mobile ferromagnetic structures
US20070144534A1 (en) 2005-11-30 2007-06-28 Carlos Mery System to prevent airway obstruction
US7237554B2 (en) 2003-10-31 2007-07-03 Restore Medical, Inc. Airway implant
WO2007075394A2 (en) 2005-12-22 2007-07-05 Juva Medical, Inc. Tissue augmentation device
US20070190108A1 (en) 2004-05-17 2007-08-16 Arindam Datta High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair
US7261702B1 (en) 1999-07-16 2007-08-28 Crossject Needleless syringe operating with an impact wave generator through a wall
US20070209665A1 (en) 2002-09-06 2007-09-13 Apneon, Inc. Self-anchoring magnetic force implant devices, systems, and methods
US20070246052A1 (en) 2006-04-20 2007-10-25 Pavad Medical, Inc. Tethered Airway Implants and Methods of Using the Same
US7288075B2 (en) 2002-06-27 2007-10-30 Ethicon, Inc. Methods and devices utilizing rheological materials
US20070256693A1 (en) 2002-09-06 2007-11-08 Apneon, Inc. Devices, systems, and methods using magnetic force systems in or on soft palate tissue
US20070257395A1 (en) 2006-05-04 2007-11-08 David Lindh Tissue holding devices and methods for making the same
US20070261701A1 (en) 2004-02-26 2007-11-15 Ira Sanders Methods and Devices for Treating Sleep Apnea and Snoring
US7297102B2 (en) 2004-07-28 2007-11-20 Ethicon, Inc. Minimally invasive medical implant and insertion device and method for using the same
US20070270631A1 (en) 2003-01-22 2007-11-22 Apneon, Inc. Magnetic force devices, systems, and methods for resisting tissue collapse within the pharyngeal conduit
WO2007134005A1 (en) 2006-05-15 2007-11-22 Mayo Foundation For Medical Education And Research Devices and methods to treat nasal passages
JP2007313337A (en) 1996-06-06 2007-12-06 Jean-Claude Laborde Endoprosthesis for vascular bifurcation
WO2007146338A2 (en) 2006-06-13 2007-12-21 Aspire Medical, Inc. Glossal engagement system and method
US20070295340A1 (en) 2006-06-23 2007-12-27 Buscemi Paul J Stiffening Procedure for Sleep Apnea
US20070295338A1 (en) 2004-12-08 2007-12-27 Ventus Medical, Inc. Nasal respiratory devices for positive end-expiratory pressure
WO2007149469A2 (en) 2006-06-21 2007-12-27 Aspire Medical, Inc. System and method for temporary tongue suspension
US20080023012A1 (en) 2005-02-08 2008-01-31 Aspire Medical, Inc. Glossopexy adjustment system and method
US20080035158A1 (en) 2003-07-22 2008-02-14 Pflueger D R Apparatus and Methods for Treating Sleep Apnea
US7337781B2 (en) 2005-04-15 2008-03-04 Restore Medical, Inc. Implant for tongue
CN201029957Y (en) 2007-03-26 2008-03-05 江阴法尔胜佩尔新材料科技有限公司 Soft palate hyperelastic NiTi bracket for treating obstructive sleep apnea low-aeration syndrome
US20080053461A1 (en) 2005-02-08 2008-03-06 Aspire Medical, Inc. Methods and devices for the treatment of airway obstruction, sleep apnea and snoring
US20080066764A1 (en) 2002-09-06 2008-03-20 Apneon, Inc. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20080066769A1 (en) 2005-02-08 2008-03-20 Aspire Medical, Inc. Airway implants and methods and devices for insertion and retrieval
US20080066767A1 (en) 2002-09-06 2008-03-20 Apneon, Inc. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20080066765A1 (en) 2002-09-06 2008-03-20 Apneon, Inc. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20080078411A1 (en) 2006-10-03 2008-04-03 Restore Medical, Inc. Tongue implant for sleep apnea
WO2008042058A1 (en) 2006-10-03 2008-04-10 Restore Medical, Inc. Tongue implant
US7360432B2 (en) 2003-12-18 2008-04-22 Wartsila Finland Oy Apparatus for detecting pressure
WO2008063218A1 (en) 2006-11-03 2008-05-29 Koninklijke Philips Electronics N.V. Devices, systems, and methods using magnetic force systems in the upper airway
US20080146868A1 (en) 2006-10-17 2008-06-19 Antoine Jean Henri Robert Adjustable implantable male incontinence device
US20080167614A1 (en) 2007-01-08 2008-07-10 David Tolkowsky Endobronchial fluid exhaler devices and methods for use thereof
US20080199824A1 (en) 2007-02-21 2008-08-21 Hargadon Paul K Magnetic dental appliance
US20080208265A1 (en) 2005-02-08 2008-08-28 Andrew Frazier System and method for percutaneous palate remodeling
WO2008118913A2 (en) 2007-03-26 2008-10-02 Baxter International Inc. Injectable void filler for soft tissue augmentation
US20080312688A1 (en) 2007-06-13 2008-12-18 Jesse G Nawrocki Bi-directional Barbed Suture
JP2009006090A (en) 2007-06-29 2009-01-15 Japan Health Science Foundation Vocal cord reinforcing tool, vocal cord atrophy preventive electrode and vocal cord atrophy preventive device including them
US20090025734A1 (en) 2007-02-27 2009-01-29 Koninklijke Philips Electronics N.V. Devices, systems, and methods to move or restrain the hyoid bone
WO2009036094A2 (en) 2007-09-12 2009-03-19 The Brigham And Women's Hospital, Inc. Magnetic prosthetic materials for implantation using natural orifice transluminal endoscopic methods
US20090078411A1 (en) 2007-09-20 2009-03-26 Kenison Michael H Downhole Gas Influx Detection
WO2009023256A3 (en) 2007-08-14 2009-04-16 Venita Chandra Devices for supporting, elevating, or compressing internal structures
WO2007132449A3 (en) 2006-05-11 2009-04-30 Yossi Gross Implantable respiration therapy device
US20090165803A1 (en) 2007-11-01 2009-07-02 Pavad Medical On-off implant for supporting the tongue
US7601164B2 (en) 2004-04-07 2009-10-13 Tze Liang Woffles Wu Surgical thread
EP2145587A2 (en) 2008-07-14 2010-01-20 Tyco Healthcare Group LP Differentiation of surgical filaments
US20100023055A1 (en) 2008-07-23 2010-01-28 Ethicon, Inc. Collapsible barbed sutures having reduced drag and methods therefor
US20100030011A1 (en) 2008-07-31 2010-02-04 Ethicon, Inc. Magnetic implants for treating obstructive sleep apnea and methods therefor
US20100024830A1 (en) 2008-07-30 2010-02-04 Ethicon, Inc. Methods and devices for forming an auxiliary airway for treating obstructive sleep apnea
US20100037901A1 (en) * 2008-08-14 2010-02-18 Rousseau Robert A Methods and devices for treatment of obstructive sleep apnea
US20100080791A1 (en) 2008-09-26 2010-04-01 Rousseau Robert A Composition and Method For Treating Tissue Defects
WO2010035303A1 (en) 2008-09-25 2010-04-01 Alessandro Rampello Improved stress-relieving mouthpiece
US20100106246A1 (en) 2008-10-24 2010-04-29 Ethicon, Inc. Methods and devices for the indirect displacement of the hyoid bone for treating obstructive sleep apnea
US20100108077A1 (en) * 2008-10-30 2010-05-06 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US20100132719A1 (en) 2008-12-01 2010-06-03 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US20100137905A1 (en) 2008-12-01 2010-06-03 Weadock Kevin S Implant systems and methods for treating obstructive sleep apnea
US20100158854A1 (en) 2008-12-19 2010-06-24 Boston Scientific Scimed, Inc. Method for treatment of airway and apparatus and kit for use therewith
US20100163056A1 (en) 2008-12-30 2010-07-01 Medartis Ag Implant
US20100211184A1 (en) 2009-02-17 2010-08-19 Rousseau Robert A Magnetic implants and methods for treating an oropharyngeal condition
US20100234946A1 (en) 2009-03-16 2010-09-16 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US20100234794A1 (en) 2009-03-12 2010-09-16 Kevin Shaun Weadock System and method for reducing surgical site infection
US20100256443A1 (en) 2007-06-12 2010-10-07 Promedon S.A. Micro sling and implantation tool for urinary incontinence and faecal incontinence treatment
US20100294284A1 (en) 2008-12-09 2010-11-25 H-Medical Apparatus, systems, and methods for constraining and/or supporting tissue structures along an airway
US20100319710A1 (en) 2009-02-18 2010-12-23 Adam Sharkawy Implant system for controlling airway passage
US20110054522A1 (en) 2009-08-27 2011-03-03 Ethicon, Inc. Barbed sutures having pledget stoppers and methods therefor
US20110100377A1 (en) 2009-10-29 2011-05-05 Ethicon, Inc. Tongue suspension system with hyoid-extender for treating obstructive sleep apnea
US20110100376A1 (en) 2009-10-29 2011-05-05 Ethicon, Inc. Fluid filled implants for treating obstructive sleep apnea
US20110100378A1 (en) 2009-10-30 2011-05-05 Ethicon, Inc. Flexible implants having internal volume shifting capabilities for treating obstructive sleep apnea
US20110144558A1 (en) 2009-12-15 2011-06-16 Ethicon, Inc. Fluid filled implants for treating medical conditions
US20110174315A1 (en) 2008-08-29 2011-07-21 Xiangmin Zhang Implanted Soft Palate Support and Implantation Method
US20110178439A1 (en) 2008-10-02 2011-07-21 Irwin John N A palate retainer with attached nasopharyngeal airway extender for use in the treatment of obstructive sleep apnea
CN102198010A (en) 2010-09-29 2011-09-28 周星 Implanted tongue traction device, traction plate, traction threads, tractor and method
US20110238111A1 (en) 2010-03-28 2011-09-29 Frank Joshua B Soft Tissue Fixation Using A Looped Suture Construct
US20110245850A1 (en) 2010-03-31 2011-10-06 Siesta Medical, Inc. Suture passer systems and methods for tongue or other tissue suspension and compression
EP2386252A1 (en) 2010-05-11 2011-11-16 Aesculap AG Continuous-filament thread having a plurality of barbs and a barbed suture
WO2012004758A1 (en) 2010-07-08 2012-01-12 Assut Europe S.P.A. Suture thread
US8142422B2 (en) 2004-04-21 2012-03-27 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US20120123449A1 (en) 1999-03-01 2012-05-17 Medtronic, Inc Bridge clip tissue connector apparatus and methods
WO2012064902A2 (en) 2010-11-09 2012-05-18 Angiotech Pharmaceuticals, Inc. Emergency self-retaining sutures and packaging
US20120160249A1 (en) 2010-12-24 2012-06-28 Thomason Thomas B Tongue advancement device for reducing obstructive sleep apnea condition
US20120245629A1 (en) 2011-03-23 2012-09-27 Gross Jeffrey M Self-retaining variable loop sutures
EP2517633A1 (en) 2011-04-29 2012-10-31 Tyco Healthcare Group LP Apparatus and method of forming barbs on a suture
WO2012170468A1 (en) 2011-06-06 2012-12-13 Ethicon, Inc. Methods and devices for soft palate tissue elevation procedures
US20130074849A1 (en) 2011-09-28 2013-03-28 Robert Rousseau Modular Tissue Securement Systems
US20130098371A1 (en) 2011-10-24 2013-04-25 Robert A. Rousseau Tissue supporting device and method
US20130133669A1 (en) 2011-11-30 2013-05-30 Robert A. Rousseau Tongue suspension device and method
US20130150872A1 (en) 2011-12-08 2013-06-13 Robert A. Rousseau Modified tissue securement fibers
US20130319427A1 (en) 2012-06-01 2013-12-05 An-Amin Jason Sung Systems and methods to treat upper pharyngeal airway of obstructive sleep apnea patients

Patent Citations (275)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006517115T5 (en) 2006-09-28
US3123007A (en) 1964-03-03 Well pump
SU1697792A1
JP2006508708T5 (en) 2006-10-19
JP2008526286T5 (en) 2009-02-12
SU927236A1
JP2007512090T5 (en) 2007-12-20
US2705492A (en) 1953-04-06 1955-04-05 Milton H Chandler Teeth protector
US3378010A (en) 1965-07-28 1968-04-16 Coldling Surgical clip with means for releasing the clamping pressure
US4024855A (en) 1974-12-30 1977-05-24 Louis Bucalo Magnetic filamentary structure and method for using the same
US4069865A (en) 1975-09-12 1978-01-24 Otis Engineering Corporation Bottom hole fluid pressure communicating probe and locking mandrel
US4290763A (en) 1979-06-15 1981-09-22 Hurst Gerald L Method for producing enclosed multipaneled envelopes
US5704895A (en) 1979-12-28 1998-01-06 American Medical Systems, Inc. Implantable penile prosthetic cylinder with inclusive fluid reservoir
US4523584A (en) 1983-03-04 1985-06-18 Medical Engineering Corporation Penile erectile system
US4557264A (en) 1984-04-09 1985-12-10 Ethicon Inc. Surgical filament from polypropylene blended with polyethylene
US4881939A (en) 1985-02-19 1989-11-21 The Johns Hopkins University Implantable helical cuff
US4839215A (en) 1986-06-09 1989-06-13 Ceramed Corporation Biocompatible particles and cloth-like article made therefrom
US5053047A (en) 1989-05-16 1991-10-01 Inbae Yoon Suture devices particularly useful in endoscopic surgery and methods of suturing
FR2651113A1 (en) 1989-08-30 1991-03-01 Gilbert Alain Device for suturing a wound in an organ, such as a blood vessel
US4950285A (en) 1989-11-27 1990-08-21 Wilk Peter J Suture device
US5123913A (en) 1989-11-27 1992-06-23 Wilk Peter J Suture device
US5067485A (en) 1990-05-14 1991-11-26 Mentor Corporation Corpus cavernosum implant device
US5311028A (en) 1990-08-29 1994-05-10 Nissin Electric Co., Ltd. System and method for producing oscillating magnetic fields in working gaps useful for irradiating a surface with atomic and molecular ions
US5393984A (en) 1990-08-29 1995-02-28 Nissin Electric Co., Inc. Magnetic deflection system for ion beam implanters
US5483077A (en) 1990-08-29 1996-01-09 Nissin Electric Co., Ltd. System and method for magnetic scanning, accelerating, and implanting of an ion beam
US5192274A (en) 1991-05-08 1993-03-09 Bierman Steven F Anchor pad for catheterization system
US6190401B1 (en) 1991-05-13 2001-02-20 United States Surgical Corporation Device for applying a meniscal staple
US5269783A (en) 1991-05-13 1993-12-14 United States Surgical Corporation Device and method for repairing torn tissue
US5485444A (en) 1991-06-07 1996-01-16 Deustsche Thomson-Brandt Gmbh Signalization of types of defects of an optical information carrier
US5192271A (en) 1991-11-25 1993-03-09 Kalb Irvin M Device and method for effecting an erection
RU2005447C1 (en) 1992-08-18 1994-01-15 Товарищество с ограниченной ответственностью - Акционерное общество закрытого типа Бюро "Денди" Snoring suppressor
US5484444A (en) 1992-10-31 1996-01-16 Schneider (Europe) A.G. Device for the implantation of self-expanding endoprostheses
US5284161A (en) 1992-11-12 1994-02-08 Karell Manuel L Snopper-the snoring stopper anti-snoring mouth device
US6241747B1 (en) 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US7806908B2 (en) 1993-05-03 2010-10-05 Quill Medical, Inc. Barbed tissue connector
US5843077A (en) 1994-06-24 1998-12-01 Somnus Medical Technologies, Inc. Minimally invasive apparatus for internal ablation of turbinates with surface cooling
US5609559A (en) 1995-05-15 1997-03-11 Weitzner; Howard B. Device for female patients to prevent involuntary loss of urine
JPH11514266A (en) 1995-10-09 1999-12-07 メドスカンド メディカル アクティエボラーグ A surgical instrument for the treatment of female urinary incontinence
WO1997013465A1 (en) 1995-10-09 1997-04-17 Medscand Medical Ab Surgical instrument for treating female urinary incontinence
US5792067A (en) 1995-11-21 1998-08-11 Karell; Manuel L. Apparatus and method for mitigating sleep and other disorders through electromuscular stimulation
JP2007313337A (en) 1996-06-06 2007-12-06 Jean-Claude Laborde Endoprosthesis for vascular bifurcation
US5683417A (en) 1996-08-14 1997-11-04 Cooper; William I. Suture and method for endoscopic surgery
US6457472B1 (en) 1996-12-12 2002-10-01 The Johns Hopkins University Method and apparatus for providing ventilatory support to a patient
US5931855A (en) 1997-05-21 1999-08-03 Frank Hoffman Surgical methods using one-way suture
US6716251B1 (en) 1997-06-13 2004-04-06 Aventis Pharmaceuticals Holdings, Inc. Implant for subcutaneous or intradermal injection
WO1999000058A1 (en) 1997-06-26 1999-01-07 Influence Medical Technologies, Ltd. Improved methods and devices for the treatment of airway obstruction, sleep apnea and snoring
US6161541A (en) 1998-06-09 2000-12-19 Influent Ltd. Hyoid expansion and suspension procedure
US20120123449A1 (en) 1999-03-01 2012-05-17 Medtronic, Inc Bridge clip tissue connector apparatus and methods
WO2000066050A1 (en) 1999-05-03 2000-11-09 Wolfgang Fege Pharynx side implant
US6638284B1 (en) 1999-06-08 2003-10-28 Ethicon, Inc. Knitted surgical mesh
US7261702B1 (en) 1999-07-16 2007-08-28 Crossject Needleless syringe operating with an impact wave generator through a wall
US6348156B1 (en) 1999-09-03 2002-02-19 Baxter International Inc. Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma
US6634362B2 (en) 1999-09-17 2003-10-21 Restore Medical, Inc. Braided implant for snoring treatment
US6523542B2 (en) 1999-09-17 2003-02-25 Pi Medical, Inc. Snoring treatment implant and method
US6250307B1 (en) 1999-09-17 2001-06-26 Pi Medical, Inc. Snoring treatment
US6578580B2 (en) 1999-09-17 2003-06-17 Restore Medical, Inc. Needle with pre-loaded implant for snoring treatment
US20010037133A1 (en) 1999-09-17 2001-11-01 Knudson Mark B. Braided palatal implant for snoring treatment
US6513530B2 (en) 1999-09-17 2003-02-04 Pi Medical, Inc. Braided palatal implant for snoring treatment
JP2001145646A (en) 1999-09-17 2001-05-29 Pi Medical Inc Embedding object and method for treating snore
US20040020498A1 (en) 1999-09-17 2004-02-05 Restore Medical, Inc. Stiff snoring implant
WO2001021107A9 (en) 1999-09-22 2002-10-03 Impra Inc Prosthesis for abdominal aortic aneurysm repair
US6408851B1 (en) 1999-10-01 2002-06-25 Manuel L. Karell Method and device for holding a tongue in a forward position
US6627600B2 (en) 2000-01-27 2003-09-30 Ardana Bioscience Limited Compressed microparticles for dry injection
US20030034312A1 (en) 2000-03-16 2003-02-20 Peter Unger Method and apparatus for treatment of biological material
US6589549B2 (en) 2000-04-27 2003-07-08 Macromed, Incorporated Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
US6431174B1 (en) 2000-08-10 2002-08-13 Pi Medical, Inc. Method and apparatus to treat conditions of the naso-pharyngeal area
US6742524B2 (en) 2000-08-10 2004-06-01 Restore Medical, Inc. Method and apparatus to treat conditions of the naso-pharyngeal area
CN2465680Y (en) 2000-11-23 2001-12-19 张鹏 Corrector for sleep apnea syndrome
US20040231678A1 (en) 2000-12-20 2004-11-25 Eduardo Fierro Adjustable autofixing sling for treatment of urinary incontinence
RU2202313C2 (en) 2001-04-02 2003-04-20 Бредов Владимир Иванович Apparatus for preventing and treating snore and respiratory standstill during sleep and for preventing gnashing of teeth
US20020144685A1 (en) 2001-04-02 2002-10-10 Ivanovich Bredov Vladimir Multipurpose device for preventing and treating snoring and sleep apnea and /or preventing gnashing of teeth
US20030004579A1 (en) 2001-06-28 2003-01-02 Ethicon, Inc. Hernia repair prosthesis and methods for making same
US7857829B2 (en) * 2001-06-29 2010-12-28 Quill Medical, Inc. Suture method
US7056331B2 (en) 2001-06-29 2006-06-06 Quill Medical, Inc. Suture method
US6599310B2 (en) 2001-06-29 2003-07-29 Quill Medical, Inc. Suture method
US7135189B2 (en) 2001-08-23 2006-11-14 Boston Scientific Scimed, Inc. Compositions and techniques for localized therapy
US6800082B2 (en) 2001-10-19 2004-10-05 Ethicon, Inc. Absorbable mesh device
US20040147811A1 (en) 2001-12-14 2004-07-29 Diederich Chris J Catheter based balloon for therapy modification and positioning of tissue
US20030149447A1 (en) 2002-02-01 2003-08-07 Morency Steven David Barbed surgical suture
US7322993B2 (en) 2002-02-04 2008-01-29 Restore Medical Inc. Stiffening pharyngeal wall treatment
US7017582B2 (en) 2002-02-04 2006-03-28 Restore Medical Inc. Stiffening pharyngeal wall treatment
US20050251255A1 (en) 2002-02-04 2005-11-10 Restore Medical Inc. Treatment for sleep apnea or snoring
US20030149445A1 (en) 2002-02-04 2003-08-07 Pi Medical, Inc. Pharyngeal wall treatment
US20100137794A1 (en) 2002-02-04 2010-06-03 Medtronic Xomed, Inc. Pharyngeal wall treatment
US20030149488A1 (en) 2002-02-04 2003-08-07 Metzger Anja K. Stiffening pharyngeal wall treatment
US20050268919A1 (en) 2002-02-04 2005-12-08 Restore Medical, Inc. Pharyngeal tissue fixation
US7669603B2 (en) 2002-02-04 2010-03-02 Medtronic Xomed, Inc. Pharyngeal wall treatment
US7146981B2 (en) 2002-02-04 2006-12-12 Restore Medical, Inc. Pharyngeal wall treatment
US20030176875A1 (en) 2002-03-07 2003-09-18 Anderson Kimberly A. Transobturator surgical articles and methods
JP2003265621A (en) 2002-03-14 2003-09-24 Univ Nihon Indwelling and collecting type stent for disease in sleep apnea syndrome
US6755868B2 (en) 2002-03-22 2004-06-29 Ethicon, Inc. Hernia repair device
US20040020492A1 (en) 2002-05-02 2004-02-05 Dubrul William R. Upper airway device and method
WO2003096928A1 (en) 2002-05-22 2003-11-27 Sofradim Production Suburethral support assembly for the treatment of female stress urinary incontinence
US20050203576A1 (en) 2002-06-07 2005-09-15 Sulamanidze Marlen A Surgical thread "aptos for cosmetic surgery
US7288075B2 (en) 2002-06-27 2007-10-30 Ethicon, Inc. Methods and devices utilizing rheological materials
US20050038472A1 (en) 2002-07-31 2005-02-17 Icon Interventional Systems, Inc. Sutures and surgical staples for anastamoses, wound closures, and surgical closures
US20040144395A1 (en) 2002-08-02 2004-07-29 Evans Douglas G Self-anchoring sling and introducer system
US20040028676A1 (en) 2002-08-06 2004-02-12 Klein Dean A. Swallowing system tissue modifier
WO2004016196A3 (en) 2002-08-14 2004-12-23 Boston Scient Ltd Systems, methods and devices relating to delivery of medical implants
US20040044366A1 (en) 2002-08-27 2004-03-04 Bonutti Peter M. Apparatus and method for securing a suture
WO2004020492A1 (en) 2002-08-30 2004-03-11 Asahi Organic Chemicals Industry Co., Ltd. Process for producing phenolic novolak
WO2004021869A3 (en) 2002-09-06 2005-01-27 Apneon Inc Systems and methods for moving and/or restraining tissue in the upper respiratory system
US6955172B2 (en) 2002-09-06 2005-10-18 Apneon, Inc. Systems and methods for moving and/or restraining the tongue in the oral cavity
US20040149290A1 (en) 2002-09-06 2004-08-05 Apneon, Inc. Devices, systems, and methods to fixate tissue within the regions of body, such as the pharyngeal conduit
US20070272257A1 (en) 2002-09-06 2007-11-29 Apneon, Inc. Magnetic force devices, systems, and methods for resisting tissue collapse within the pharyngeal conduit
US20070267027A1 (en) 2002-09-06 2007-11-22 Apneon, Inc. Magnetic force devices, systems, and methods for resisting tissue collapse within the pharyngeal conduit
US20040139975A1 (en) 2002-09-06 2004-07-22 Apneon, Inc. Magnetic force devices, systems, and methods for resisting tissue collapse within the pharyngeal conduit
WO2004021870A3 (en) 2002-09-06 2004-12-02 Apneon Inc Magnetic force devices, systems, and methods for resisting tissue collapse within the pharyngal conduit
US20070209665A1 (en) 2002-09-06 2007-09-13 Apneon, Inc. Self-anchoring magnetic force implant devices, systems, and methods
US20050159637A9 (en) 2002-09-06 2005-07-21 Apneon, Inc. Devices, systems, and methods to fixate tissue within the regions of body, such as the pharyngeal conduit
US20080066764A1 (en) 2002-09-06 2008-03-20 Apneon, Inc. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20070144531A1 (en) 2002-09-06 2007-06-28 Apneon, Inc. Device, systems and methods having mobile ferromagnetic structures
US20070119463A1 (en) 2002-09-06 2007-05-31 Apneon, Inc. Systems and methods for moving and/or restraining tissue in the upper respiratory system
US20060005843A9 (en) 2002-09-06 2006-01-12 Apneon, Inc. Magnetic force devices, systems, and methods for resisting tissue collapse within the pharyngeal conduit
US20070102004A1 (en) 2002-09-06 2007-05-10 Apneon Inc. Systems and methods for moving and/or restraining tissue in the upper respiratory system
US20080066767A1 (en) 2002-09-06 2008-03-20 Apneon, Inc. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20080066765A1 (en) 2002-09-06 2008-03-20 Apneon, Inc. Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20060289015A1 (en) 2002-09-06 2006-12-28 Apneon, Inc. Magnetic devices, systems, and methods placed in or on a tongue
US7360542B2 (en) 2002-09-06 2008-04-22 Apneon, Inc. Devices, systems, and methods to fixate tissue within the regions of body, such as the pharyngeal conduit
US7367340B2 (en) 2002-09-06 2008-05-06 Apneon, Inc. Systems and methods for moving and/or restraining tissue in the upper respiratory system
US20080221684A1 (en) 2002-09-06 2008-09-11 Apneon, Inc. Devices, systems, and methods to fixate tissue within the regions of body, such as the pharyngeal conduit
US20070256693A1 (en) 2002-09-06 2007-11-08 Apneon, Inc. Devices, systems, and methods using magnetic force systems in or on soft palate tissue
US20070000497A1 (en) 2002-09-06 2007-01-04 Apneon, Inc. Devices, systems, and methods using magnetic force systems in or on tissue
DE10245076B4 (en) 2002-09-27 2004-09-02 Karl-Heinz Bachmann Instruments and procedures for the surgical treatment of female urinary incontinence
US20050121039A1 (en) 2002-10-04 2005-06-09 Brooks Stephen N. Altering the stiffness, size and/or shape of tissues for breathing disorders and other conditions
US20050115572A1 (en) 2002-10-04 2005-06-02 Brooks Stephen N. Electrically activated alteration of body tissue stiffness for breathing disorders
US20040102796A1 (en) 2002-11-19 2004-05-27 J. Donald Hill Conduit coupling devices and methods for employing such devices
WO2004060311A3 (en) 2002-12-30 2004-11-18 Quiescence Medical Inc Apparatus and methods for treating sleep apnea
US20050199248A1 (en) 2002-12-30 2005-09-15 Quiescence Medical, Inc. Apparatus and methods for treating sleep apnea
US20060206197A1 (en) 2002-12-30 2006-09-14 Hesham Morsi Endovascular balloon graft
US20050082452A1 (en) 2003-01-06 2005-04-21 Lutron Electronics Co., Inc. Roller shade mounting system
US20040153127A1 (en) 2003-01-15 2004-08-05 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern Californ Treatments for snoring using injectable neuromuscular stimulators
US20070270631A1 (en) 2003-01-22 2007-11-22 Apneon, Inc. Magnetic force devices, systems, and methods for resisting tissue collapse within the pharyngeal conduit
US20060083767A1 (en) 2003-02-27 2006-04-20 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
WO2004084709A3 (en) 2003-03-20 2005-01-27 Apneon Inc Devices, systems, and methods to fixate tissue within the regions of body, such as the pharyngeal conduit
WO2004103196A1 (en) 2003-05-26 2004-12-02 Anthony Francis Connell A differential tissue expander implant
US6981944B2 (en) 2003-07-07 2006-01-03 Ethicon, Inc. Implantable surgical mesh having a lubricious coating
US20080035158A1 (en) 2003-07-22 2008-02-14 Pflueger D R Apparatus and Methods for Treating Sleep Apnea
US6899105B2 (en) 2003-09-19 2005-05-31 Restore Medical, Inc. Airway implant cartridge and kit
US20050092334A1 (en) 2003-10-31 2005-05-05 Restore Medical, Inc. Airway implant
US20070204866A1 (en) 2003-10-31 2007-09-06 Restore Medical, Inc. Airway implant
US7213599B2 (en) 2003-10-31 2007-05-08 Restore Medical, Inc. Airway implant
US7237554B2 (en) 2003-10-31 2007-07-03 Restore Medical, Inc. Airway implant
US20070227545A1 (en) 2003-10-31 2007-10-04 Restore Medical, Inc. Soft palate implant
US20070233276A1 (en) 2003-10-31 2007-10-04 Restore Medical, Inc. Tongue implant
US7401611B2 (en) 2003-10-31 2008-07-22 Restore Medical, Inc. Airway implant
WO2005046554A3 (en) 2003-11-05 2005-11-10 Jed E Black Altering the stiffness, size, and/or shape of tissues for breathing disorders and other conditions
US7166570B2 (en) 2003-11-10 2007-01-23 Angiotech International Ag Medical implants and fibrosis-inducing agents
WO2005051292A3 (en) 2003-11-20 2006-07-13 Apneon Inc Devices systems, and methods to fixate tissue within the regions of the body, such as the pharyngeal conduit
US20050126563A1 (en) 2003-12-15 2005-06-16 Van Der Burg Erik J. System and method for hyoidplasty
US7360432B2 (en) 2003-12-18 2008-04-22 Wartsila Finland Oy Apparatus for detecting pressure
US20050267571A1 (en) 2003-12-23 2005-12-01 Spence Paul A Tissue fastening systems and methods utilizing magnetic guidance
US20050165352A1 (en) 2004-01-23 2005-07-28 Scimed Life Systems, Inc. Stent delivery catheter
WO2005082452A1 (en) 2004-02-26 2005-09-09 Ira Sanders A method and device for the treatment of obstructive sleep apnea and snoring
US20070261701A1 (en) 2004-02-26 2007-11-15 Ira Sanders Methods and Devices for Treating Sleep Apnea and Snoring
US7601164B2 (en) 2004-04-07 2009-10-13 Tze Liang Woffles Wu Surgical thread
US20050267532A1 (en) 2004-04-07 2005-12-01 Wu Tze Liang W Surgical thread
US8142422B2 (en) 2004-04-21 2012-03-27 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US20050267531A1 (en) 2004-05-14 2005-12-01 Ruff Gregory L Suture methods and devices
US20070190108A1 (en) 2004-05-17 2007-08-16 Arindam Datta High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair
US20050267321A1 (en) 2004-06-01 2005-12-01 Shadduck John H Elastomeric magnetic nanocomposite biomedical devices
WO2005122954A1 (en) 2004-06-14 2005-12-29 Boston Scientific Scimed, Inc. Systems, methods and devices relating to implantable supportive slings
US20050279365A1 (en) 2004-06-18 2005-12-22 Armijo Dennis F Anti-snoring apparatus and method
WO2006012188A1 (en) 2004-06-24 2006-02-02 Restore Medical, Inc. Airway implant
US20060079935A1 (en) 2004-06-30 2006-04-13 Alwin Kolster Suture for wound closure, tissue approximation, tissue support, suspension and/or fixation
US20060228391A1 (en) 2004-07-12 2006-10-12 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
US7297102B2 (en) 2004-07-28 2007-11-20 Ethicon, Inc. Minimally invasive medical implant and insertion device and method for using the same
US7442389B2 (en) 2004-08-20 2008-10-28 Artes Medical, Inc. Methods of administering microparticles combined with autologous body components
US20060093644A1 (en) 2004-08-20 2006-05-04 Gerhard Quelle Methods of administering microparticles combined with autologous body components
US20070144535A1 (en) 2004-09-21 2007-06-28 Hegde Anant V Implant for treatment of sleep disorders
US20070295338A1 (en) 2004-12-08 2007-12-27 Ventus Medical, Inc. Nasal respiratory devices for positive end-expiratory pressure
US20060150986A1 (en) 2004-12-15 2006-07-13 Aspire Medical, Inc. System and method for hyoidplasty
US20070288057A1 (en) 2005-01-04 2007-12-13 Klinikum Der Universitat Regensburg Implant Device for the Non-Pneumatic, Adjustable Positioning of a Human or Animal Body Part
WO2006072571A1 (en) 2005-01-04 2006-07-13 Klinikum Der Universität Regensburg Implant device for the non-pneumatic adjustable positioning of a human or animal body part
JP2008529608A (en) 2005-02-08 2008-08-07 アスピール・メディカル・インコーポレイティッド System and method for transdermal tongue arthroplasty
US20080053461A1 (en) 2005-02-08 2008-03-06 Aspire Medical, Inc. Methods and devices for the treatment of airway obstruction, sleep apnea and snoring
US20080023012A1 (en) 2005-02-08 2008-01-31 Aspire Medical, Inc. Glossopexy adjustment system and method
US20080066769A1 (en) 2005-02-08 2008-03-20 Aspire Medical, Inc. Airway implants and methods and devices for insertion and retrieval
US20060207608A1 (en) 2005-02-08 2006-09-21 Mark Hirotsuka System and method for percutaneous glossoplasty
US20060207612A1 (en) 2005-02-08 2006-09-21 Jasper Jackson Tissue anchoring system for percutaneous glossoplasty
US20080208265A1 (en) 2005-02-08 2008-08-28 Andrew Frazier System and method for percutaneous palate remodeling
US20060241339A1 (en) 2005-02-23 2006-10-26 Cook Timothy C Method and apparatus for an adjustable implantable continence device
US20060185673A1 (en) 2005-02-24 2006-08-24 Restore Medical, Inc. Combination sleep apnea treatment
WO2006108145A1 (en) 2005-04-06 2006-10-12 Boston Scientific Scimed, Inc. Systems, devices, and methods for treating pelvic floor disorders
US7337781B2 (en) 2005-04-15 2008-03-04 Restore Medical, Inc. Implant for tongue
US20060266369A1 (en) 2005-05-27 2006-11-30 Prospex Medical Ii, Inc. Devices and methods for treating sleep disorders
US20070005110A1 (en) 2005-06-29 2007-01-04 Collier John P Braided barbed suture
US20070005109A1 (en) 2005-06-29 2007-01-04 Popadiuk Nicholas M Barbed suture
US20070102010A1 (en) 2005-10-07 2007-05-10 Lemperle Stefan M Naso-pharyngeal tissue engineering
US20070123996A1 (en) 2005-10-14 2007-05-31 Kiminobu Sugaya Stem cell comprising tissue substitutes
US7888119B2 (en) 2005-10-14 2011-02-15 University Of Central Florida Research Foundation, Inc. Tissue substitutes comprising stem cells and reduced ceria
WO2007056583A1 (en) 2005-11-09 2007-05-18 Aspire Medical, Inc. Glossoplasty using tissue anchor glossopexy with volumetric tongue reduction
US20070144539A1 (en) 2005-11-09 2007-06-28 Van Der Burg Erik Glossoplasty using tissue anchor glossopexy with volumetric tongue reduction
US20070110788A1 (en) 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
US20070144534A1 (en) 2005-11-30 2007-06-28 Carlos Mery System to prevent airway obstruction
WO2007075394A2 (en) 2005-12-22 2007-07-05 Juva Medical, Inc. Tissue augmentation device
US20070246052A1 (en) 2006-04-20 2007-10-25 Pavad Medical, Inc. Tethered Airway Implants and Methods of Using the Same
US7850894B2 (en) 2006-05-04 2010-12-14 Ethicon, Inc. Tissue holding devices and methods for making the same
US20070257395A1 (en) 2006-05-04 2007-11-08 David Lindh Tissue holding devices and methods for making the same
WO2007132449A3 (en) 2006-05-11 2009-04-30 Yossi Gross Implantable respiration therapy device
WO2007134005A1 (en) 2006-05-15 2007-11-22 Mayo Foundation For Medical Education And Research Devices and methods to treat nasal passages
WO2007146338A2 (en) 2006-06-13 2007-12-21 Aspire Medical, Inc. Glossal engagement system and method
WO2007149469A2 (en) 2006-06-21 2007-12-27 Aspire Medical, Inc. System and method for temporary tongue suspension
US20080035160A1 (en) 2006-06-21 2008-02-14 Woodson Beverly T System and method for temporary tongue suspension
US20070295340A1 (en) 2006-06-23 2007-12-27 Buscemi Paul J Stiffening Procedure for Sleep Apnea
US20080078411A1 (en) 2006-10-03 2008-04-03 Restore Medical, Inc. Tongue implant for sleep apnea
WO2008042058A1 (en) 2006-10-03 2008-04-10 Restore Medical, Inc. Tongue implant
US20080146868A1 (en) 2006-10-17 2008-06-19 Antoine Jean Henri Robert Adjustable implantable male incontinence device
WO2008063218A1 (en) 2006-11-03 2008-05-29 Koninklijke Philips Electronics N.V. Devices, systems, and methods using magnetic force systems in the upper airway
US20080167614A1 (en) 2007-01-08 2008-07-10 David Tolkowsky Endobronchial fluid exhaler devices and methods for use thereof
US20080199824A1 (en) 2007-02-21 2008-08-21 Hargadon Paul K Magnetic dental appliance
US20090025734A1 (en) 2007-02-27 2009-01-29 Koninklijke Philips Electronics N.V. Devices, systems, and methods to move or restrain the hyoid bone
WO2008118913A2 (en) 2007-03-26 2008-10-02 Baxter International Inc. Injectable void filler for soft tissue augmentation
CN201029957Y (en) 2007-03-26 2008-03-05 江阴法尔胜佩尔新材料科技有限公司 Soft palate hyperelastic NiTi bracket for treating obstructive sleep apnea low-aeration syndrome
US20100256443A1 (en) 2007-06-12 2010-10-07 Promedon S.A. Micro sling and implantation tool for urinary incontinence and faecal incontinence treatment
US20080312688A1 (en) 2007-06-13 2008-12-18 Jesse G Nawrocki Bi-directional Barbed Suture
JP2009006090A (en) 2007-06-29 2009-01-15 Japan Health Science Foundation Vocal cord reinforcing tool, vocal cord atrophy preventive electrode and vocal cord atrophy preventive device including them
WO2009023256A3 (en) 2007-08-14 2009-04-16 Venita Chandra Devices for supporting, elevating, or compressing internal structures
WO2009036094A2 (en) 2007-09-12 2009-03-19 The Brigham And Women's Hospital, Inc. Magnetic prosthetic materials for implantation using natural orifice transluminal endoscopic methods
US20090078411A1 (en) 2007-09-20 2009-03-26 Kenison Michael H Downhole Gas Influx Detection
US20090165803A1 (en) 2007-11-01 2009-07-02 Pavad Medical On-off implant for supporting the tongue
EP2145587A2 (en) 2008-07-14 2010-01-20 Tyco Healthcare Group LP Differentiation of surgical filaments
US20100023055A1 (en) 2008-07-23 2010-01-28 Ethicon, Inc. Collapsible barbed sutures having reduced drag and methods therefor
US20100024830A1 (en) 2008-07-30 2010-02-04 Ethicon, Inc. Methods and devices for forming an auxiliary airway for treating obstructive sleep apnea
US20100030011A1 (en) 2008-07-31 2010-02-04 Ethicon, Inc. Magnetic implants for treating obstructive sleep apnea and methods therefor
JP2011530385A (en) 2008-08-14 2011-12-22 エシコン・インコーポレイテッドEthicon, Incorporated Method and apparatus for treating obstructive sleep apnea
US20100037901A1 (en) * 2008-08-14 2010-02-18 Rousseau Robert A Methods and devices for treatment of obstructive sleep apnea
US20130174857A1 (en) 2008-08-14 2013-07-11 Robert A. Rousseau Methods and devices for treatment of obstructive sleep apnea
US8413661B2 (en) 2008-08-14 2013-04-09 Ethicon, Inc. Methods and devices for treatment of obstructive sleep apnea
WO2010019376A2 (en) 2008-08-14 2010-02-18 Ethicon, Inc. Methods and devices for treatment of obstructive sleep apnea
US20110174315A1 (en) 2008-08-29 2011-07-21 Xiangmin Zhang Implanted Soft Palate Support and Implantation Method
WO2010035303A1 (en) 2008-09-25 2010-04-01 Alessandro Rampello Improved stress-relieving mouthpiece
US20100080791A1 (en) 2008-09-26 2010-04-01 Rousseau Robert A Composition and Method For Treating Tissue Defects
US20110178439A1 (en) 2008-10-02 2011-07-21 Irwin John N A palate retainer with attached nasopharyngeal airway extender for use in the treatment of obstructive sleep apnea
US20100106246A1 (en) 2008-10-24 2010-04-29 Ethicon, Inc. Methods and devices for the indirect displacement of the hyoid bone for treating obstructive sleep apnea
WO2010051195A1 (en) 2008-10-30 2010-05-06 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US20100108077A1 (en) * 2008-10-30 2010-05-06 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
CN102271624A (en) 2008-10-30 2011-12-07 伊西康公司 Implantation systems and methods for the treatment of obstructive sleep apnea
US20100137905A1 (en) 2008-12-01 2010-06-03 Weadock Kevin S Implant systems and methods for treating obstructive sleep apnea
WO2010065341A1 (en) 2008-12-01 2010-06-10 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US20100132719A1 (en) 2008-12-01 2010-06-03 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US20130186412A1 (en) 2008-12-01 2013-07-25 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US8800567B2 (en) * 2008-12-01 2014-08-12 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US20100294284A1 (en) 2008-12-09 2010-11-25 H-Medical Apparatus, systems, and methods for constraining and/or supporting tissue structures along an airway
US20100158854A1 (en) 2008-12-19 2010-06-24 Boston Scientific Scimed, Inc. Method for treatment of airway and apparatus and kit for use therewith
US20100163056A1 (en) 2008-12-30 2010-07-01 Medartis Ag Implant
US20130118505A1 (en) 2009-02-17 2013-05-16 Robert A. Rousseau Magnetic implants and methods for treating an oropharyngeal condition
US20100211184A1 (en) 2009-02-17 2010-08-19 Rousseau Robert A Magnetic implants and methods for treating an oropharyngeal condition
US20100319710A1 (en) 2009-02-18 2010-12-23 Adam Sharkawy Implant system for controlling airway passage
US20100234794A1 (en) 2009-03-12 2010-09-16 Kevin Shaun Weadock System and method for reducing surgical site infection
US8307831B2 (en) 2009-03-16 2012-11-13 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US20100234946A1 (en) 2009-03-16 2010-09-16 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US20110054522A1 (en) 2009-08-27 2011-03-03 Ethicon, Inc. Barbed sutures having pledget stoppers and methods therefor
US20110100376A1 (en) 2009-10-29 2011-05-05 Ethicon, Inc. Fluid filled implants for treating obstructive sleep apnea
US20110100377A1 (en) 2009-10-29 2011-05-05 Ethicon, Inc. Tongue suspension system with hyoid-extender for treating obstructive sleep apnea
US20110100378A1 (en) 2009-10-30 2011-05-05 Ethicon, Inc. Flexible implants having internal volume shifting capabilities for treating obstructive sleep apnea
US20110144558A1 (en) 2009-12-15 2011-06-16 Ethicon, Inc. Fluid filled implants for treating medical conditions
US20110238111A1 (en) 2010-03-28 2011-09-29 Frank Joshua B Soft Tissue Fixation Using A Looped Suture Construct
US20110245850A1 (en) 2010-03-31 2011-10-06 Siesta Medical, Inc. Suture passer systems and methods for tongue or other tissue suspension and compression
US20110282386A1 (en) 2010-05-11 2011-11-17 Aesculap Ag Continuous-filament thread having a plurality of barbs and a barbed suture
EP2386252A1 (en) 2010-05-11 2011-11-16 Aesculap AG Continuous-filament thread having a plurality of barbs and a barbed suture
WO2012004758A1 (en) 2010-07-08 2012-01-12 Assut Europe S.P.A. Suture thread
US20130103078A1 (en) * 2010-07-08 2013-04-25 Maurizio Longo Suture thread
CN102198010A (en) 2010-09-29 2011-09-28 周星 Implanted tongue traction device, traction plate, traction threads, tractor and method
WO2012041205A1 (en) 2010-09-29 2012-04-05 Zhou Xing Implanted tongue traction device, pull plate, pull lines, tractor and method thereof
WO2012064902A2 (en) 2010-11-09 2012-05-18 Angiotech Pharmaceuticals, Inc. Emergency self-retaining sutures and packaging
US20120160249A1 (en) 2010-12-24 2012-06-28 Thomason Thomas B Tongue advancement device for reducing obstructive sleep apnea condition
US20120245629A1 (en) 2011-03-23 2012-09-27 Gross Jeffrey M Self-retaining variable loop sutures
EP2517633A1 (en) 2011-04-29 2012-10-31 Tyco Healthcare Group LP Apparatus and method of forming barbs on a suture
WO2012170468A1 (en) 2011-06-06 2012-12-13 Ethicon, Inc. Methods and devices for soft palate tissue elevation procedures
US20130074849A1 (en) 2011-09-28 2013-03-28 Robert Rousseau Modular Tissue Securement Systems
US20130098371A1 (en) 2011-10-24 2013-04-25 Robert A. Rousseau Tissue supporting device and method
US20130133669A1 (en) 2011-11-30 2013-05-30 Robert A. Rousseau Tongue suspension device and method
US20130150872A1 (en) 2011-12-08 2013-06-13 Robert A. Rousseau Modified tissue securement fibers
US20130319427A1 (en) 2012-06-01 2013-12-05 An-Amin Jason Sung Systems and methods to treat upper pharyngeal airway of obstructive sleep apnea patients

Non-Patent Citations (40)

* Cited by examiner, † Cited by third party
Title
Cole et al., "Snoring: A Review and a Reassessment", J. of Otolaryngology, vol. 24, No. 5 pp. 303-306 (1995).
Copy of Notification of Transmittal of the International Search Report and the Written Opinion of the International Search Authority or the Declaration mailed on Dec. 25, 2010; PCT/US2010/023152; International Filing Date: Apr. 2, 2010.
Copy of Notification of Transmittal of the International Search Report and the Written Opinion of the International Search Authority or the Declaration mailed on Feb. 3, 2010; PCT/US2009/051921; International Filing Date: Jul. 28, 2009.
Database WPI Week 198312, Thomson Scientific, London, GB; AN 1983-D9513K XP002693421, -& SU 927 236 A1 (Petrozazodsk Univ) May 15, 1982 abstract (see figures 7 & 8).
Friedman et al., "A System and Method for Inserting a Medical Device for Treatment of Sleep Apnea via the Nasal Passage, and Device Therefor", Dec. 29, 2008, U.S. Appl. No. 61/203,758, p. 8 & p. 6/8.
Harries et al., "The Surgical treatment of snoring", J. of Laryngology and Otology, vol. 110, Issue 12 pp. 1105-1106 (1996).
Huang et al., "Biomechanics of snoring", Endeavour, vol. 19(3): pp. 96100 (1995).
International Search Report dated Apr. 2, 2013 for International Patent Application No. PCT/US2012/067708.
International Search Report dated Apr. 29, 2010 for International Patent Application No. PCT/US2009/065293.
International Search Report dated Apr. 9, 2013 for International Patent Application No. PCT/US2012/061569.
International Search Report dated Dec. 21, 2009 for International Patent Application No. PCT/US2009/057661.
International Search Report dated Dec. 22, 2009 for International Patent Application No. PCT/US2009/061223.
International Search Report dated Dec. 29, 2009 for International Patent Application No. PCT/US2009/061455.
International Search Report dated Feb. 28, 2011 for International Patent Application No. PCT/US2010/059673.
International Search Report dated Jan. 14, 2011 for International Patent Application No. PCT/US2010/052628.
International Search Report dated Jan. 20, 2011 for International Patent Application No. PCT/US2010/052644.
International Search Report dated Jan. 21, 2010 for International Patent Application No. PCT/US2009/052110.
International Search Report dated Jan. 24, 2011 for International Patent Application No. PCT/US2010/052649.
International Search Report dated May 24, 2013 for International Patent Application No. PCT/US2012/066011.
International Search Report dated May 25, 2010 for International Patent Application No. PCT/US2010/023152.
International Search Report dated May 25, 2010 for International Patent Application No. PCT/US2010/025778.
International Search Report dated Nov. 4, 2009 for International Patent Application No. PCT/US2009/052126.
International Search Report dated Oct. 2, 2013 re: PCT/US2013/043238.
International Search Report re: PCT/US2012/0565677 dated Nov. 27, 2012.
MacMillan Dictionary, Fiber, MacMillan Publisher, Liminted 2009-2014.
Medtronic AIRvance System for Obstructive Sleep Apnea. http://www.medtronic.com/for-healthcare-professionals/products-therapies/ear-nose-throat/sleep-disordered-breathing-products/airvance-system-for-obstructive-sleep-apnea/index.htm.
Pang, Kenny et al., "Tongue Suspension Suture in Obstructive Sleep Apnea", Operative Techniques in Otolaryngology, vol. 17, No. 4, pp. 252256 (2006).
Repose Genioglossus Advancement, INFLUENT Medical, www.influent.com, 1 page (2008).
Schleef et al., "Cytokine Activation of Vascular Endothelium, Effects on Tissue-Type 1 Plasminogen Activator Inhibitor" The J. of Biological Chem., vol. 263, No. 12, pp. 5797-5803 (1988).
Schwab et al., "Upper airway and soft tissue changes induced by CPAP in normal subject", Am. J. Respit. Crit. Care Med., vol. 154, No. 4 pp. 1106-1116 (1996).
Schwartz et al., "Effects of electrical stimulation to the soft palate on snoring and obstructive sleep apnea", J. Prosthetic Dentistry, vol. 76 pp. 273-281 (1996).
Shamsuzzaman et al., "Obstructive Sleep Apnea; Implications for Cardiac and Vascular Disease", JAMA vol. 290, No. 14 pp. 1906-1914 (2003).
Teles et al., "Use of Palatal Lift Prosthesis on Patient Submitted to Maxillectomy: A Case Report", Applied Cancer Res. vol. 25(3), pp. 151-154 (2005).
The Advance System, Aspire Medical, Inc. www.aspiremedical.com, 3 pp (2008).
The Pillar Procedure, Restore Medical, Inc. www.restoremedical.com, 2 pp (2008).
U.S. Appl. No. 13/486,293 filed Jun. 1, 2012.
Vicente et al., "Tongue-Base Suspension in Conjunction with Uvulopapatopharyngoplasty for Treatment of Severe Obstructive Sleep Apnea: Long-term Follow-Up Results", The Laryngoscope, vol. 116 pp. 1223-1227 (2006).
Wassmuth et al., "Cautery-assisted palatal stiffening operation for the treatment of obstructive sleep apnea syndrome", Otolaryngology-Head and Neck Surgery, vol. 123, pp. 55-60 (2000).
Wiltfang et al., "First results on daytime submandibular electrostimulation of suprahyoidal muscles to prevent night-time hypopharyngeal collapse in obstructive sleep apnea syndrome", Intl J. of Oral & Maxillofacial Surgery vol. 28 pp. 21-25 (1999).
Written Opinion dated Nov. 27, 2012 for International Patent Application No. PCT/US2012/056577.

Also Published As

Publication number Publication date Type
WO2013181327A1 (en) 2013-12-05 application
US20130319427A1 (en) 2013-12-05 application

Similar Documents

Publication Publication Date Title
US7669603B2 (en) Pharyngeal wall treatment
US6502574B2 (en) Lateral stiffening snoring treatment
US20070261701A1 (en) Methods and Devices for Treating Sleep Apnea and Snoring
US20070288057A1 (en) Implant Device for the Non-Pneumatic, Adjustable Positioning of a Human or Animal Body Part
US20100037901A1 (en) Methods and devices for treatment of obstructive sleep apnea
US6401717B1 (en) Snoring treatment
US20080208265A1 (en) System and method for percutaneous palate remodeling
US20110100376A1 (en) Fluid filled implants for treating obstructive sleep apnea
US6513530B2 (en) Braided palatal implant for snoring treatment
US7363926B2 (en) Apparatus and methods for treating sleep apnea
US6516806B2 (en) Compliant snoring treatment implant
US20080188947A1 (en) Methods and devices for treating sleep apnea and snoring
US6601584B2 (en) Contracting snoring treatment implant
US20080023012A1 (en) Glossopexy adjustment system and method
US6578580B2 (en) Needle with pre-loaded implant for snoring treatment
US20060150986A1 (en) System and method for hyoidplasty
US20110174315A1 (en) Implanted Soft Palate Support and Implantation Method
US20080058584A1 (en) Glossopexy tension system and method
US7992567B2 (en) System and method for percutaneous glossoplasty
US7845356B2 (en) Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20080066766A1 (en) Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20080066765A1 (en) Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US7780730B2 (en) Nasal implant introduced through a non-surgical injection technique
US20080066764A1 (en) Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20090044814A1 (en) Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions

Legal Events

Date Code Title Description
AS Assignment

Owner name: ETHICON, INC., NEW JERSEY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SUNG, AN-MIN JASON;ROUSSEAU, ROBERT A.;LINDH, DAVID C.;REEL/FRAME:028411/0259

Effective date: 20120604