WO1986001712A1 - Reconstitution device - Google Patents

Reconstitution device Download PDF

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Publication number
WO1986001712A1
WO1986001712A1 PCT/US1985/001486 US8501486W WO8601712A1 WO 1986001712 A1 WO1986001712 A1 WO 1986001712A1 US 8501486 W US8501486 W US 8501486W WO 8601712 A1 WO8601712 A1 WO 8601712A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
drug
liquid container
reconstitution device
securing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1985/001486
Other languages
English (en)
French (fr)
Inventor
Hugh M. Forman
Donald B. Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter Travenol Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Travenol Laboratories Inc filed Critical Baxter Travenol Laboratories Inc
Priority to DE8585904182T priority Critical patent/DE3583139D1/de
Publication of WO1986001712A1 publication Critical patent/WO1986001712A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means

Definitions

  • the diluent may be for example a dextrose solution, a saline solution or even water.
  • Many such drugs are supplied in powder form and packaged in glass vials.
  • Other drugs, such as some used in chemotherapy, are packaged in glass vials in a l quid state.
  • the drugs In order for powdered drugs to be given intravenously to a patient, the drugs must first be placed in liquid form.
  • Other drugs, although in a liquid state, must be still be diluted before administration ,to a patient.
  • reconstitution also includes dilution.
  • One way of reconstituting a powdered drug is to first inject the liquid diluent into the drug vial.
  • This may be performed by means of a combination syringe and syringe needle having diluent therein.
  • liquid in the syringe is injected into the vial.
  • the vial is shaken to mix the powdered drug with the liquid.
  • the liquid is then withdrawn back into the syringe.
  • the steps may be repeated several times.
  • the syringe is withdrawn.
  • the drug may then be injected into a patient.
  • Another common means of drug administration is to inject the reconstituted drug in the syringe into a parenteral solution container, such as a Minibag" flexible parenteral solution container or Viaflex® flexible parenteral solution container sold by Travenol Laboratories of Deerfield, Illinois, a wholly owned subsidiary of the assignee of the present invention.
  • a parenteral solution container such as a Minibag" flexible parenteral solution container or Viaflex® flexible parenteral solution container sold by Travenol Laboratories of Deerfield, Illinois, a wholly owned subsidiary of the assignee of the present invention.
  • These containers may already have therein dextrose or saline solution, for example.
  • the drug, now mixed with the solution in the parenteral solution container is delivered through an intravenous solution administration set to a vein access site of the patient.
  • a reconstitution device sold by Travenol Laboratories, product code No. 2B8064. That device includes a double pointed needle and guide tubes mounted around both ends of the needle.
  • This prior art reconstitution device is utilized to place the drug vial in flow communication with a flexible walled parenteral solution container for example.
  • liquid in the solution container may be forced into the drug vial by squeezing the solution container.
  • the vial is then shaken.
  • the liquid in the vial is withdrawn by squeezing air from the solution container into the vial.
  • the pressurized air in the vial acts as a pump to force the liquid in the vial back into the solution container.
  • the devices of the present invention solve the problems outlined above. Drug exposure to hospital personnel is minimized or eliminated. Drug labeling, to ensure that the proper drug is administered to the correct patient, is made unnecessary by means of a reconstitution device that is securely retained on both the parenteral solution container and the drug vial, preventing inadvertent separation of the vial from the solution container. Determination of what drug has been mixed in a specific solution container can be made simply by looking at the pre-existing label on the attached drug vial.
  • the device of the present invention includes valve means to prevent communication between the drug and the diluent until just before use, even though the solution container and the drug vial have been previously coupled by the device, thus facilitating a longer time period between the time of coupling and drug infusion.
  • the invention is directed to a device for reconstituting a substance such as a drug, which includes means to secure the device to both first and second containers, such that each securing means includes an interlock that prevents inadvertent detachment of the device from either the first or the second container.
  • the interlock permits a positive mechanical fixturing of the reconstitution device to the two containers and is more than simply a friction fit.
  • the device further includes flow path means for placing the first and second container interiors in open communication.
  • the first and second container securing means are mounted about the flow path means.
  • the device further includes means for entering the interior of the first container and means for entering the interior of the second container.
  • the flow path means and both entering means are embodied in a double-pointed needle assembly.
  • the invention is also directed to a drug reconstitution system including a flexible-walled liquid container defining a chamber and having an injection site, as well as a drug container defining a chamber and including an access site.
  • the system further includes an initially separate reconstitution device such as discussed above, coupled to both containers.
  • the invention is further directed to a reconstitution device which includes means for securing the device to both a liquid container and a drug container, piercing means for piercing both the injection site of the liquid container and the access site of the drug container, and flow path means for placing the chambers of the drug and liquid containers into open communication.
  • the device further includes valve means for selectively opening the flow path means.
  • the flow path means and valve means may further include separate first and second flow path segments. The first flow path segment is mounted at least partially within the drug container securing means and the second flow path segment is mounted in the liquid container securing means. A so included is a sealing segment between the two separate flow path segments, with an aperture through the sealing segment.
  • the invention is still further directed to a reconstitution device including means for securing the device to a liquid container and a drug container, wherein at least the drug container securing means includes an interlock.
  • the drug container securing means has base means secured to flow path means, at least one upstanding wall portion extending from the base means and a ridge extending inwardly from an inside wall of at least one of the wall portions, near the top thereof. Further included is a wall slot in each wall portion having an annular ridge, the wall slots extending from the base means to the annular ridges.
  • Liquid and drug container piercing means are also included in this embodiment of the invention to provide access to the container interiors. In this embodiment it is preferred that there are at least two upstanding wall portions, spaced from each other to permit bending toward and away from each other.
  • the reconstitution device may further include inner ribs within the liquid container securing means for a tighter fit with the liquid container injection site.
  • the device may include a cup removably mounted in the liquid container securing means and including an opening in the base of the cup through which the flow path means of the device (in th s case a needle) extends.
  • the cup is adapted for retention on the injection site of the liquid container even after the reconstitution device is removed, serving as a further indication that a drug has been added to the solution container.
  • the invention is also directed to a reconstitution device that includes flow path means, securing means and container piercing means, wherein at least the liquid container securing means has an interlock to prevent the inadvertent removal of the device from the liquid container.
  • the liquid container securing means includes base means secured to the flow path means and at least two wall segments extending outwardly from the base means, the wall segments defining a volume having a generally cylindrical shape and being disposed around and spaced from at least a portion of the flow path means.
  • a retaining projection extends inwardly from near the top of at least one of the wall segments.
  • a locking ring is sl dably mounted about the exterior of the wall segments and is disposed for sliding movement between a first position near the base means to a second position near the top of the wall segments. In the second position the locking ring exerts inward pressure on the wall segments, urging the retaining projections against the liquid container mounted therein, typically the tubular injection site thereof.
  • the invention is further directed to a device including flow path means and means for securing the device to both a liquid container and a drug container. At least the liquid container securing means includes an interlock to prevent inadvertent detachment of the device from the liquid container. Liquid and drug container piercing means are included to access the interiors of the containers.
  • the liquid container securing means is disposed relative to the liquid container piercing means such that the liquid container securing means may be secured to the liquid container, i.e., the injection site thereof, without the injection site being totally pierced by the piercing means, so that the injection site may be completely pierced after the securing means is initially affixed to the liquid container.
  • Fig. 1 is an exploded perspective view of one embodiment of the invention, including valve means, illustrating attachment of the reconstitution device to a flexible walled liquid container and to a drug vial container to form a reconstitution system.
  • Fig. 2 is an exploded view of the reconstitution device illustrated in Fig. 1.
  • Fig. 3 is a top plan view of the vial adapter in the reconstitution device illustrated in Fig. 1.
  • Fig.4 is a bottom plan view of the bag adapter utilized in the reconstitution device of Fig. 1.
  • Fig. 5 is a cross-sectional view of the reconstitution device with the valve closed and illustrating attachment of the device to both the liquid container and the drug container.
  • Fig.6 is a cross-sectional view like Fig.5, but with the valve open.
  • Fig. 7 is a cross-sectional view of a modified device with the bag adapter disposed relative to the needle so that the needle has not yet totally pierced the injection site on the bag.
  • Fig.8 is a perspective, cut-away view of another embodiment of the device, without valve means, but including an interlock on the vial adapter.
  • Fig. 9 is a cross-sectional exploded view of the device illustrated in Fig.8.
  • Fig. 10 is a side elevational view of the device illustrated in Fig.8.
  • Fig. 11 is a side elevational view rotated 45 degrees from Fig. 10.
  • Fig. 12 is a perspective view, illustrating the device attached to a drug vial only, with a needle protector retained on the bag adapter.
  • Fig. 12a is similar to Fig. 12 but with the needle protector removed and the bag adapter secured to a flexible liquid container.
  • Fig. 13 is a plan view of the vial adapter of the device of Fig. 8.
  • Fig. 13a is a cross-sectional view of the device of Fig.8.
  • Fig. 15a is a cross-sectional view illustrating the molding operation for the vial adapter of the device of Fig.8, taken at Line 15a-15a of Fig. 15.
  • Fig. 15b is a cross-sectional view, rotated 45 degrees about the vertical axis from Fig. 15a, taken at line 15b-15b of Fig. 15.
  • Fig. 17 is a cross-sectional view of yet another embodiment of the reconstitution device, illustrating a detachable cup.
  • Fig. 18 is a cut-away, exploded view of the reconstitution device illustrated in Fig. 17, in partial cross-section.
  • Fig. 19 is a perspective view of still another embodiment of the invention, illustrating a device having interlocks for securement to both the flexible liquid container and the drug container.
  • Fig.20 is a cross-sectional view of the device illustrated in Fig. 19.
  • Figs. 1 through 20 there is illustrated various embodiments of the reconstitution device and system of the present invention.
  • Figs. 1 through 6 a first embodiment of the reconstitution device and system of the present invention.
  • Fig. 1 illustrates a reconstitution device 30 for securely coupling and permitting selective fluid flow between a first container such as a drug vial 32 and a second container such as a flexible-walled medical liquid container 34.
  • the drug vial 32 contains a first component such as a drug 36, shown in powdered form.
  • the drug 36 may be in another form, such as a liquid.
  • the metal band 42 initially includes a top portion (not shown) covering the top of the rubber stopper 40.
  • the top portion is separated from the metal band 42 by means of a weakened score line disposed at inner circle 46 of the metal band 42.
  • the top portion is removed to provide access to the rubber stopper 40.
  • the second container 34 as illustrated in Fig. 1 is a flexible walled, compressible medical parenteral solution container of known construction, including two sheets 48, 50 of flexible plastic material sealed together about their peripheries.
  • the liquid container 34 includes an administration port 52 and an injection site 54, both forming part of the container 34.
  • the administration port 52 includes a plastic tube 56 with a membrane (not shown) of standard construction therein which closes off the administration port 52.
  • a spike of a standard intravenous administration set (not shown) is inserted into the tube 56, piercing the membrane and allowing liquid 60 such as dextrose solution, saline solution, water or other fluid in the container 34 to exit the liquid container 34, flow through the administration set and, via vein access means, flow into the intravenous system of a patient.
  • the injection site 54 may include an outer tube 62 secured between the two plastic sheets.
  • An inner tube 64 having a membrane 66 closing the passage of the inner tube 64 is mounted in and sealed to the outer tube 62. A portion of the inner tube 64 extends out of the outer tube 62.
  • the injection site 54 typically includes a polyisoprene or latex situs 68 which is pierceable by a needle and resealable upon withdrawal of the needle.
  • the situs includes a skirt 70 which grips the outer surface 72 of the inner tube 64.
  • the situs 68 may be secured to the inner tube 64 by means of a shrink band 74 conforming to the outer surface 72 of the inner tube 64 and to the skirt 70 of the situs 68.
  • the reconstitution device 30 includes means for securing the device to the first container such as the drug container 32 and means for securing the device to the second container such as the iquid container 34.
  • the drug container securing means is noted generally by vial adapter 76.
  • the liquid container securing means is noted generally by bag adapter 78.
  • the vial adapter 76 is secured over the mouth 38 of the drug vial 32.
  • the bag adapter 78 is secured over the situs 68 and inner tube 64 of the injection site 54.
  • the separate parts of the reconstitution device 30 include the vial adapter 76, a sealing segment 80, a first flow path means segment such as first needle 82, the bag adapter 78, a second flow path means segment such as a second needle 84, and a locking ring 160.
  • the vial adapter 76 includes base means such as a generally circular base 88.
  • a vial adapter skirt 90 extends away from the base 88.
  • the vial adapter skirt 90 may be constructed of a single wall portion, two wall portions are better and in the preferred embodiments of the invention the vial adapter skirt 90 is formed by four upstanding wall portions 92. Each wall portion 92 includes a top 94 opposite the base 88.
  • a ridge 96 extends inwardly from an inside wall 98 of at least one and preferably all of the wall portions 92, near the top 94 thereof.
  • the ridge or ridges 96 can be made to extend inwardly a great distance if required, as explained further below.
  • the ridges 96 snap into the underside 43 of the vial mouth 38 to create a mechanical interlock, securing the vial adapter 76 to the vial 32, as seen in Fig.5.
  • Wall slots 100 are disposed in each of the wall portions 92 having an annular ridge 96. Each of the wall slots 100 extend from the base 88 to an annular ridge 96. The wall portions 92 are spaced from each other to permit bending of the wall portions toward and away from each other as will be explained further below.
  • the vial adapter 76 includes a stem 102 extending from the center of the base 88.
  • the stem is substantially cylindrical.
  • a cylindrical opening 104 extends through the stem 102 and base 88.
  • the stem 102 has a flange 106 extending about the circumference of the upper portion of the stem 102.
  • the cavity mold 221 includes wall slot formers 234 and spacer slot formers 236.
  • the wall slot former ends 235 extend to and define the inner ledges 232 of the ridges 224.
  • the wall slot formers 234 in the cavity mold 221 fit into the wall slot former cavities 237 within the core mold 223.
  • the ridges 224 are formed between the wall slot former ends 235 and the wall slot former cavity ends 239. It is seen that a wedging action is created between the wall slot formers 234 of the cavity mold 221 and the wall slot former cavities 237 of the core mold 223. Because of this wedging formation, more than minor draft angles must be provided.
  • the wall slots 228 have edges which converge at an angle of from about 5° to 8 ⁇ from the base 206 to the inner ledge 232.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Radiation-Therapy Devices (AREA)
PCT/US1985/001486 1984-09-14 1985-08-07 Reconstitution device Ceased WO1986001712A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE8585904182T DE3583139D1 (de) 1984-09-14 1985-08-07 Wiederfuellvorrichtung.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/650,481 US4759756A (en) 1984-09-14 1984-09-14 Reconstitution device
US650,481 1984-09-14

Publications (1)

Publication Number Publication Date
WO1986001712A1 true WO1986001712A1 (en) 1986-03-27

Family

ID=24609096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1985/001486 Ceased WO1986001712A1 (en) 1984-09-14 1985-08-07 Reconstitution device

Country Status (7)

Country Link
US (1) US4759756A (enExample)
EP (1) EP0195018B1 (enExample)
JP (1) JPS62500427A (enExample)
CA (1) CA1239619A (enExample)
DE (1) DE3583139D1 (enExample)
NO (1) NO861899L (enExample)
WO (1) WO1986001712A1 (enExample)

Cited By (62)

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EP0367549A3 (en) * 1988-10-31 1991-01-09 Lawrence A. Lynn Medical connector
EP0416454A3 (en) * 1989-09-06 1991-11-13 Npbi Nederlands Produktielaboratorium Voor Bloedtransfusieapparatuur En Infusievloeistoffen B.V. Method of and apparatus for administering medicament to a patient
EP0499764A1 (en) * 1991-02-22 1992-08-26 Instituto De Biologia Y Sueroterapia, S.A. Device for the transfer of liquids between flexible containers and vials
WO1994000094A1 (en) * 1992-06-22 1994-01-06 Mary Therese Purcell A reconstitution device
WO1994008549A1 (en) * 1992-10-16 1994-04-28 Abbott Laboratories An improved latching piercing pin for use with fluid vials of varying sizes
US5308347A (en) * 1991-09-18 1994-05-03 Fujisawa Pharmaceutical Co., Ltd. Transfusion device
US5374263A (en) * 1992-10-13 1994-12-20 Automatic Liquid Packaging Full withdrawal container and method
US5472434A (en) * 1993-05-14 1995-12-05 Akzo N.V. Spike retainer system
US5496301A (en) * 1992-09-25 1996-03-05 Cobe Laboratories, Inc. Fluid sampling device for closed collection systems
US5526853A (en) * 1994-08-17 1996-06-18 Mcgaw, Inc. Pressure-activated medication transfer system
DE19513666C1 (de) * 1995-04-11 1996-11-28 Behringwerke Ag Vorrichtung zum Zusammenführen einer ersten flüssigen und einer zweiten festen oder flüssigen Komponente mittels Unterdruck unter sterilen Bedingungen
US5641010A (en) * 1994-07-14 1997-06-24 International Medication Systems, Limited Mixing and dispensing apparatus
US5647845A (en) * 1995-02-01 1997-07-15 Habley Medical Technology Corporation Generic intravenous infusion system
US5685866A (en) * 1991-12-18 1997-11-11 Icu Medical, Inc. Medical valve and method of use
US5694686A (en) * 1991-12-18 1997-12-09 Icu Medical, Inc. Method for assembling a medical valve
FR2780878A1 (fr) * 1998-07-10 2000-01-14 Frederic Senaux Capuchon de transfert encliquetable
EP1034772A1 (fr) * 1999-03-10 2000-09-13 Maco Pharma Dispositif de transfert d'une substance contenue dans un flacon dans une poche de solute
DE19930791A1 (de) * 1999-07-03 2001-01-11 Fresenius Ag Arretierbarer Nadeladapter
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FR2817465A1 (fr) * 2000-12-06 2002-06-07 Technoflex Sa Dispositif de reconstitution notamment pour le melange de substances dans le domaine medical
US6916309B2 (en) 2000-07-11 2005-07-12 Icu Medical, Inc. Medical valve with positive flow characteristics
WO2007069907A1 (en) * 2005-12-12 2007-06-21 Ge Healthcare As Spike-accommodating container holder
WO2007149960A3 (en) * 2006-06-22 2008-04-17 Baxter Int Medicant reconstitution container and system
WO2011060829A1 (en) * 2009-11-20 2011-05-26 Carmel Pharma Ab Medical device connector
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EP2462913A1 (en) 2010-12-10 2012-06-13 Fresenius Medical Care Deutschland GmbH Insert and vial for the infusion of liquids
WO2012152704A1 (en) * 2011-05-06 2012-11-15 Sanofi-Aventis Deutschland Gmbh Active valve for drug delivery
EP2771047A1 (en) * 2011-12-19 2014-09-03 Medimop Medical Projects Ltd Vial adapter for use with syringe having widened distal syringe tip
CN104717953A (zh) * 2012-10-16 2015-06-17 株式会社Jms 穿刺针适配器
US9283324B2 (en) 2012-04-05 2016-03-15 Medimop Medical Projects, Ltd Fluid transfer devices having cartridge port with cartridge ejection arrangement
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US10278897B2 (en) 2015-11-25 2019-05-07 West Pharma. Services IL, Ltd. Dual vial adapter assemblage including drug vial adapter with self-sealing access valve
US10285907B2 (en) 2015-01-05 2019-05-14 West Pharma. Services IL, Ltd. Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
US10646404B2 (en) 2016-05-24 2020-05-12 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including identical twin vial adapters
US10688295B2 (en) 2013-08-07 2020-06-23 West Pharma. Services IL, Ltd. Liquid transfer devices for use with infusion liquid containers
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Also Published As

Publication number Publication date
JPH0566818B2 (enExample) 1993-09-22
CA1239619A (en) 1988-07-26
EP0195018A4 (en) 1988-01-21
EP0195018A1 (en) 1986-09-24
US4759756A (en) 1988-07-26
NO861899L (no) 1986-06-24
DE3583139D1 (de) 1991-07-11
JPS62500427A (ja) 1987-02-26
EP0195018B1 (en) 1991-06-05

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