US3788369A - Apparatus for transferring liquid between a container and a flexible bag - Google Patents

Apparatus for transferring liquid between a container and a flexible bag Download PDF

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US3788369A
US3788369A US3788369DA US3788369A US 3788369 A US3788369 A US 3788369A US 3788369D A US3788369D A US 3788369DA US 3788369 A US3788369 A US 3788369A
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means
needle
bag
liquid
end
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F Killinger
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Upjohn Co
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Upjohn Co
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089Containers or vials which are to be joined to each other in order to mix their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10Bag-type containers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/1475Inlet or outlet ports
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/2017Piercing means having three or more piercing ends
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068Venting means
    • A61J1/2075Venting means for external venting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079Filtering means
    • A61J1/2082Filtering means for gas filtration

Abstract

A resiliently flexible bag has a chamber with inlet and outlet passageways, the outlet passageway being connectible to a tube and the inlet passageway having perforable closure means. The chamber is normally filled with a liquid, such as a saline solution. A cannula is mounted upon a container for insertion through the closure member and communication between the chamber in the bag and the interior of the container. If the container holds a liquid, intermittent, manual compressing and releasing of the flexible bag causes the liquid within the bag to move into the container or the liquid in the container to move into the bag, depending upon their relative vertical positions. A special cannula and container therefor are provided to furnish filtered air to the bag prior to connection thereof with the container if such air is needed.

Description

United States Patent Killinger Jan. 29, 1974 [75] Inventor: Fred M. Killinger, Portage, Mich.

[73] Assignee: The Upjohn Company, Kalamazoo,

Mich.

22 Filed: June2, 1971 21 Appl.No.:149,321

[52] U.S. Cl 141/114, 128/272, 141/330,

141/383 [51] Int. Cl B65b 3/16 [58] Field of Search... 141/329, 382, 330, 383, 311, 141/384, 313, 317,10,l8,l7, 68,19, 21, 23, 24, 114; 128/272; 222/212, 215

Primary Examiner-Houston S. Bell, Jr

Assistant Examiner-Frederick R. Schmidt Attorney, Agent, or Firm-Woodhams, Blanchard & Flynn [57] ABSTRACT A resiliently flexible bag has a chamber with inlet and outlet passageways, the outlet passageway being connectible to a tube and the inlet passageway having per forable closure means. The chamber is normally filled with a liquid, such as a saline solution. A cannula is mounted upon a container for insertion through the closure member and communication between the chamber in the bag and the interior of the container. 1f the container holds a liquid, intermittent, manual compressing and releasing of the flexible bag causes the liquid within the bag to move into the container or the liquid in the container to move into the bag, depending upon their relative vertical positions. A special cannula and container therefor are provided to furnish filtered air to the bag prior to connection thereof with the container if such air is needed.

4 Claims, 10 Drawing Figures PATENTEDJAH 23 mm 3.788 3 69 sum 3 '05 3 APPARATUS FOR TRANSFERRING LIQUID BETWEEN A CONTAINER AND A FLEXIBLE BAG BACKGROUND OF THE INVENTION This invention relates in general to an apparatus for transferring a liquid between a container and a flexible bag and/or mixing liquids and, more particularly, to types thereof adapted for placing additives in an infusion bag.

It is commonplace to feed or treat a medical patient injecting nutrients and/or medicaments in liquid form into a vein. It has also been commonplace to use resiliently flexible containers, such as plastic bags, to hold the liquid, such as a saline solution, dextrose or glucose, to be injected into the vein of the patient. Furthermore, it is well known in practice to add medicaments to the liquid being injected into the patients vein, thereby avoiding the inconvenience and discomfort of independent injections of these additives. However, it has been found necessary to package the additives in airtight glass vials for a number of reasons. In the first place, Federal regulations require the use of glass containers for the storage of parenterals. These containers must be air-tight for certain medicaments because of their relatively rapid deterioration in the presence of ambient air. Also, the containers must be capable of sterilization at temperatures which would damage some plastics. Furthermore, certain of these additives will, over a period of time, react with certain types of plastic containers, whereas, they will not react with glass containers.

Glass syringes can be used as storage containers for some additives, but not others because of air leakage, risk of contamination and the short shelf life of certain medicaments after they have been mixed with a diluent. Also, glass syringes are expensive, difficult to fill and inconvenient to store.

The most convenient method for moving additives from a glass vial to the flexible bag containing the liquid carrier is by means of a cannula or transfer needle which is mounted or mountable upon the additive vial. Usually the cannula must be moved relative to the additive vial in order to effect communication between the cannula and the interior of the vial. Otherwise, the airtight condition within the container would be disturbed prior to use of the additive therein.

Where the additive is a liquid, it has in the past been transferred from the vial to the bag either by relying upon gravity, which produces an exasperatingly slow flow, or by using a syringe to remove the liquid from the vial and then injecting it into the bag. However, where the additive is a dry material, it has heretofore been necessary to first put the dry material into solution within the vial and thereafter transfer the solution from the vial to the flexible bag either by the process of gravity flow or by using a syringe. Obviously, these procedures have produced inefficiency and have risked the chance of producing unsterile conditions in both the mixing and administration of the additives involved.

Accordingly, a primary object of this invention has been the provision of an apparatus for quickly mixing an I additive with a liquid for intraveneous injection wherein the additive is contained in a relatively rigid glass vial and, sometimes, in a dry form.

A further object of this invention has been the provision of a method for transferring liquid between a resiliently flexible bag and a relatively rigid glass vial interconnected by a transfer needle wherein the vial, under some circumstances, contains a dry material which must be dissolved, said method being adapted to use some of the liquid within the flexible bag as the diluent after which the method moves the solution from the vial into the flexible bag.

A further object of the invention is the provision of a method and apparatus, as aforesaid, whereby sterile air can be added to the contents of the flexible bag prior to communication thereof with the interior of the additive vial in order to facilitate the transfer of liquid therebetween.

Other objects and purposes of this invention will become apparent to persons familiar with this type of equipment upon reading the following descriptive material and examining the accompanying drawings, in which:

FIG. 1 is a broken front elevational view of a liquid transfer apparatus embodying the invention.

FIG. 2 is a broken side elevational view of said apparatus.

FIG. 3 is a broken front elevational view of said apparatus showing the bag in a compressed condition.

FIG. 4 is a broken front elevational view illustrating the apparatus after the compressed bag is released.

FIG. 5 is a broken fragment of the front elevational view of said apparatus in the inverted position.

FIG. 6 is a sectional view taken along the line VIVI in FIG. 1.

FIG. 7 is a broken fragment of a front elevational view of said apparatus illustrating a modified additive container.

FIG. 8 is a side elevational view of a transfer needle container.

FIG. 9 is a sectional view taken along the line IXIX in FIG. 8.

FIG. 10 is an enlarged broken fragment of FIG. 9 showing a modified transfer needle and container.

For convenience in description, the terms upper, lower and words of similar import shall have reference to the apparatus of the invention as appearing in FIGS. 1 and 2. The terms inner, outer" and derivatives thereof shall have reference to the geometric center of said apparatus and the component parts thereof.

SUMMARY OF THE INVENTION The objects and purposes of the invention, including those set forth above, have been met by providing a resiliently flexible and liquid-tight bag having inlet and outlet spouts at the lower end thereof. The outlet spout is connectibe to a tube for the purpose of conducting liquid from the bag into a vein of a patient. The inlet spout has a closure means which can be penetrated by a transfer needle mounted upon a rigid glass vial holding a medicament which must be added to the liquid contents of the bag. The method concerns the movement of liquid from the rigid glass container into the flexible bag by alternately squeezing and releasing the bag in a pumping action, while holding the vial above the bag.

The method also pertains to a situation where a dry material is disposed within the vial and some of the liquid within the bag is moved by said pumping action into the vial to dissolve the dry material. The solution is then transferred from the vial into the bag by the pumping action. A transfer needle and container therefor including air filter means are used in the method for providing additional sterile air in the flexible bag if necessary.

DETAILED DESCRIPTION The liquid transfer apparatus 10, one preferred embodiment of which is illustrated in FIG. 1, includes a resiliently flexible bag or receptacle 11 which, in this particular instance, is fabricated from two sheets 12 and 13 of plastic material, which sheets are firmly secured to each other along corresponding edges thereof to form a chamber 14 and flange 16 which extends completely around the bag. Cylindrical inlet and outlet spouts l7 and 18, respectively, are integral with the front and rear sheets 12 and 13 and communicate with the chamber at the lower end thereof. The outlet spout 18 is initially covered with a cap 19, and the bag is filled with a liquid 22 such a saline solution, glucose or the like. The cap 19 can be removed and replaced by a tube 23 (FIG. 4) for the purpose of transferring the liquid 22 from the bag 11 into the vein of a patient in a conventional manner.

The inlet spout 17 (FIG. 1) is closed by a membrane 24 (FIG. 6) spaced upwardly from the lower end thereof and by a removable closure member 26 which covers the lower end of the spout 17. Both the membrane 24 and the lower wall 27 of the closure member 26 are penetrable by a cannula or transfer needle 28 mounted upon the vial 29.

The bag 1 1 may be fabricated from a variety of plastic materials, such as polyethylene, polypropylene or polyvinyl-chloride, and the flange 16 thereon is provided with a plurality of openings 32 near the upper and lower ends thereof for suspending the apparatus or the bag 11 by means of hooks 33, FIGS. 1 and 2.

The vial 29 (FIG. 1) is comprised of a glass bottle 34 (FIG. 6) with a perforable rubber seal or stopper 36, which may be made from natural or synthetic materials, inserted in or extending across the open upper end of the neck 37 on said bottle 34. The seal 36 is held in position by a metal collar 38 which is spun on or otherwise secured to the neck 37. The collar 38 has an upper wall 39 with a central opening 42 through which a cylindrical stem 43 extends. Said stem 43 has an integral outwardly projecting and annular flange 44 that is clamped between the wall 39 and the seal 36 (FIG. 6). These two parts can also be made in one piece.

The needle 28 may be of the substantially conventional transfer type having points at both ends and being rigidly engaged approximately midway between the ends thereof by a substantially cylindrical hub 46. A sleeve 47 is firmly secured at one end upon the hub 46 and extends downwardly therefrom concentrically with the needle 28. The lower end of the sleeve 47 has an outwardly extending, annular flange 48 which is spaced upwardly from the lower end of the needle. The sleeve 47 is slideably but snugly supported upon the stem 43 when the lower end of the needle 28 is disposed within the stem 43 but spaced upwardly from seal 36. When it is desired to effect communication between the needle 28 and the interior 49 of the bottle 34, said bottle and the sleeve 47 are relatively moved from their FIG. 1 positions to their FIG. 3 positions wherein the lower end of the needle 28 pierces the seal 36 and extends into the interior 49.

In this particular embodiment of the invention, the vial 29 contains a dry material, such as a freeze-dried medicament, which must be mixed with a diluent. The liquid solution is then added to the liquid in the chamber 14 for injection into the vein of the patient. However, it will be apparent that the apparatus and method of the invention can and will be used where the material within the vial 29 is initially a liquid.

FIG. 7 illustrates an alternate apparatus 60 including a bag 11 and vial 61 which are interconnectible by a transfer needle 62 having a hub 63. The vial 61, which may be similar to the vial disclosed in US. Pat. No. 3,464,414, has two compartments 68 and 72 separated by a constriction 66 in which a plug 67 is removably disposed. The plug 67 is forced out of the constriction and into the lower compartment 68 by pressure applied to the stopper 69 as it is moved from a raised position into its lowered position appearing in FIG. 7.

Normally, a dry material, such as a freeze-dried medicament, is disposed within the lower compartment 68 and, after the plug 67 is placed in the constriction 66, a diluent is placed in the upper compartment 72. Thereafter, the stopper 69 and collar 73 are mounted on the bottle 64.

The bag 11 may be closed, after it is initially filled with a liquid, so that there is insufficient air therein to be removed and replaced by the liquid solution 74 in vial 61. It will be noted that, in the alternate apparatus a 60, no liquid is required from the bag to be mixed with the liquid in the vial 61. Accordingly, it may be desirable to increase the amount of air in the bag 11 in order to facilitate the pumping action by which such air is moved into the vial 61 in order to displace the liquid 74 therefrom. Nevertheless, it is also desirable that the air which is placed in the bag 11 should be sterile. This result is achieved by means of the structure disclosed in F IGS. 8 and 9 or the structure disclosed in FIG. 10.

Specifically, the transfer needle 62 (FIG. 9) is placed in a two part cylindrical container 76 having upper and lower cup-shaped parts 77 and 78, respectively, the open ends of which are telescopically engaged. The upper wall 79 of the upper cup 77 is comprised of a filter 82 through which ambient air can pass, but which blocks contaminants in said air. Thus, after removing the lower cup 78, the lower end 83 of the needle 62 (FIG. 9) is inserted through the closure member 26, as shown in FIG. 7, so that ambient air can pass through the filter 82 into the chamber 84 within the upper part 77 thence through the needle 62 and into the bag 11. Ordinarily, the bag 11 will be in its FIG. 5 position dur ing this operation so that no liquid will escape from the bag.

After the desired amount of air has been released into the bag 11, the upper part 77 (FIG. 9) of the container 76 is removed from the needle and its upper end is inserted into and through the stopper 69 (FIG. 7) of the vial 61, for example. The transfer of liquid from the vial 61 into the bag 11 can then proceed as discussed above with respect to vial 29.

Under some circumstances, there may be insufficient room in the bag to add additional air. In such case the upper part 77 may be removed from the needle 62 and some of the liquid within the bag 11 urged out through the needle by squeezing the bag. Then, before releasing the pressure on the bag, the upper part 77 is returned to the needle so that the air, thereafter drawn into the bag to replace the discharged liquid, is filtered and sterile.

In another version of the invention, the transfer needle 62 is replaced by a transfer needle 90 (FIG. in which the hub 91 thereof also comprises the filter element. That is, the hub 91 is provided with a plurality of small lengthwise bores 92 which act as filter passageways through which air can pass, but which block contaminants. Thus, after the lower part 93 of the container 94 is removed from the upper part 96 thereof, ambient air can pass upwardly through the bores 92 into the chamber 97 and thence downwardly through the needle 90 and into the bag 11.

OPERATION The operation of the apparatus 10, as well as the manner in which the method is carried out by means of thedisclosed apparatus, will be apparent to persons skilled in this art from the aforegoing description. However, for convenience, they are specifically discussed hereinafter.

In operation, where the additive in the via] 29 is initially in liquid form and there is sufficient air space in the bag 11 for such liquid, the needle 28 (FIG. 6) is inserted into and through the lower wall 27 of the closure member 26 with the bag 11 in its inverted position of FIG. 5. The bag is then manually squeezed and released intermittently with a pumping action whereby air is first forced upwardly into the vial 29 and liquid is thereafter urged downwardly into the bag until all of the liquid in the vial 29 has been transferred into the bag 11.

If there is insufficient air in the bag 11, the transfer needle 62 or the transfer'needle 90, with its corresponding container upper part 77 and 96, respectively, is utilized to increase the amount of sterile air. Where a vial 29 is to be used, which has its own needle, the transfer needle 62 or 90 is then removed from the closure member 26 and the needle 28 is inserted through said closure member in its place.

Where the vial is furnished with a non-liquid additive which must be dissolved in the liquid contained in the bag, then the needle 28 is urged downwardly relative to the bottle 34 until the needle penetrates the seal 36 and communicates with the interior 49 of the bottle 34. The needle 28 of the vial 29 containing the dry material is then inserted upwardly, as shown in FIG. 1, through the lower wall 27 of the closure member 26 and through the membrane 24 so that it is in communication with the chamber 14. These penetrations by the needle 28 can be reversed, if desired. The bag 1 1 is then squeezed or compressed, as appearing in FIG. 3, so that some of the liquid therein moves downwardly through the needle 28 into the bottle 34. When the pressure on the bag is released, the air compressed within the bottle 34 bubbles up through the liquid in the bag 11, as appearing in FIG. 4. The bottle 34, containing the dry material plus some of the liquid from the bag 11, is now agitated, as by shaking, until the dry material is dissolved in the portion of the liquid which has been forced into the bottle 34 through the needle 28.

After the solution in the glass bottle 34 is completed, the apparatus 10 is inverted, as appearing in FIG. 5, and the alternate compression and release of the bag 11 is repeated until all of the liquid has been forced out of the bottle 34 and down through the needle 28 into the LII bag 11. This is accomplished by virtue of the fact that 6 somewhat. Thus, when the bag is released, the compressed air forces the liquid down through the needle into the bag.

The closure member 26 and the membrane 24 are designed so that they will automatically close, after the needle 28 is removed, and provide a leak proof seal to prevent accidental discharge of the liquid through the inlet spout under normal operating conditions. That is, the force of gravity will not be sufficient to produce a leak of the liquid 22 through the inlet spout 17.

The via] 61 (FIG. 7) requires some preparation before use in that the dry material must be mixed with the diluent to produce the liquid 74. This procedure is well knownfl'hereafter, the transfer needle 62 or the transfer needle is caused to penetrate the closure member 26 and the membrane 24 and the operation of the vial 61 with the bag 11 will be substantially the same as discussed above with respect to a vial 29 containing a liquid additive. The apparatus disclosed herein is capable of performing the method claimed hereinafter. However, it will be readily recognized that other specific types of apparatus can be utilized to carry out the claimed method.

Accordingly, although particular preferred embodiments of the invention have been disclosed above in detail for illustrative purposes, it will be recognized that variations or modifications of the disclosed structures, including the rearrangement of parts, lie within the scope of the present invention.

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. An apparatus for transferring and mixing liquids, comprising:

resiliently flexible bag means having a liquid holding chamber and a pair of integral outlet means connected to one end of the chamber;

closure means on said outlet means;

a liquid within said chamber substantially, but not entirely, filling said chamber and said outlet means so that some air space exists within said bag means;

rigid vial means having a transfer needle attached thereto and adapted to communicate with the interior of said vial means, said vial means being totally closed and at least partially filled with a medicament adapted to be mixed with said liquid, said vial means having a perforable closure structure at one end thereof; and

said vial means having a sleevelike support member fixedly secured thereto and projecting outwardly from said one end of said vial means in substantial alignment with the perforable closure structure, and said needle being sharpened at both ends and being at least partially disposed and slidably supported by said sleevelike support member, one end of said needle being positioned directly adjacent the perforable closure structure and being insertable therethrough to communicate with the interior of said vial means, the other end of said needle thereafter being insertable through the closure means associated with one of the outlet means of said bag means for permitting communication between said chamber and said vial means; and

an actuator sleeve disposed in surrounding relationship to said needle and having one end thereof fixedly connected to a center portion of said needle, the other end of said actuator sleeve being disposed in surrounding relationship to said sleevelike support member, and detent means coacting between said support member and said sleeve for normally maintaining said sleeve and said needle in a first position wherein the one end thereof is positioned closely adjacent the perforable closure structure, said sleeve being manually slidable from said first position toward said closure structure for causing said one end of said needle to penetrate said closure structure;

said bag means being manually collapsible for pumping liquid between said rigid vial means and said bag means through said outlet means and said needle, the flow of liquid being in a downward direction, by alternately compressing and releasing said bag means.

2. An apparatus according to claim 1, wherein said closure means associated with one of said outlet means includes a self-closing seal means adapted to be penetrated by the other end of said needle for permitting communication between said bag means and said vial means, said self-closing seal means being capable of automatically closing and sealing to prevent leakage therethrough when the needle is withdrawn therefrom so as to again close off said chamber.

3. An apparatus for transferring and mixing a liquid and a medicament, comprising:

flexible bag means having a liquid holding chamber therein, and a liquid within said chamber substantially, but not entirely, filling said chamber so that some air space exists within said bag means;

said bag means including first and second tubuiar portions fixedly secured thereto and projecting outwardly from one side thereof, said tubular portions communicating with said chamber for permitting liquid to be supplied to or removed therefrom; one of said tubular portions comprising an outlet spout adapted to be connected to an intravenous tube, and means associated with the free end of said outlet spout for normally maintaining same in a closed condition;

said other tubular portion comprising an inlet spout, and closure means associated with said inlet spout adjacent the free end thereof for normally sealingly closing same, said closure means including a sealing member fixedly and sealingly engaged with said inlet spout adjacent the free end thereof and extending across the passageway defined within the interior of said spout for closing same, said sealing member being constructed of a resilient material permitting penetration thereof by a needle so as to allow communication with said chamber while the resilient material of said sealing member automatically expands to close and seal the aperture formed by the needle after the needle has been withdrawn from the sealing member;

rigid vial means having a compartment therein which is at least partially filled with a medicament adapted to be mixed with a liquid, said vial means having a transfer needle mounted thereon and adapted for communication with said compartment, the needle being provided with a pointed end thereon remote from said compartment and being insertable through the sealing member on said inlet spout for providing communication between said compartment and said chamber;

said vial means including a perforable resilient closure member at one end thereof for totally closing and sealing said compartment, said needle being pointed at the other end thereof, said other end being normally disposed adjacent said perforable closure member for penetrating same so as to permit said needle to communicate with said compartment, and means mounted on said vial means adja cent said one end thereof and disposed exteriorly of said perforable closure member for slidably supporting said needle while effectively preventing tilting of said needle so as to facilitate penetration of said perforable closure member by said other end of said needle; and

said bag means being manually collapsible for pumping liquid between said vial means and said bag means through said inlet spout and said needle, the flow of liquid between said compartment and said chamber being caused by alternately compressing and releasing said bag means.

4. An apparatus according to claim 3, wherein said inlet and outlet spouts are disposed adjacent and in substantially parallel relationship to one another and extend outwardly from one end of said bag means, and

said bag means being provided with means associated with the other end thereof for permitting said bag means to be suspended from a suitable holding device. a=

Claims (4)

1. An apparatus for transferring and mixing liquids, comprising: resiliently flexible bag means having a liquid holding chamber and a pair of integral outlet means connected to one end of the chamber; closure means on said outlet means; a liquid within said chamber substantially, but not entirely, filling said chamber and said outlet means so that some air space exists within said bag means; rigid vial means having a transfer needle attached thereto and adapted to communicate with the interior of said vial means, said vial means being totally closed and at least partially filled with a medicament adapted to be mixed with said liquid, said vial means having a perforable closure structure at one end thereof; and said vial means having a sleevelike support member fixedly secured thereto and projecting outwardly from said one end of said vial means in substantial alignment with the perforable closure structure, and said needle being sharpened at both ends and being at least partially disposed and slidably supported by said sleevelike support member, one end of said needle being positioned directly adjacent the perforable closure structure and being insertable therethrough to communicate with the interior of said vial means, the other end of said needle thereafter being insertable through the closure means associated with one of the outlet means of said bag means for permitting communication between said chamber and said vial means; and an actuator sleeve disposed in surrounding relationship to said needle and having one end thereof fixedly connected to a center portion of said needle, the other end of said actuator sleeve being disposed in surrounding relationship to said sleeve-like support member, and detent means coacting between said support member and said sleeve for normally maintaining said sleeve and said needle in a first position wherein the one end thereof is positioned closely adjacent the perforable closure structure, said sleeve being manually slidable from said first position toward said closure structure for causing said one end of said needle to penetrate said closure structure; said bag means being manually collapsible for pumping liquid between said rigid vial means and said bag means through said outlet means and said needle, the flow of liquid being in a downward direction, by alternately compressing and releasing said bag means.
2. An apparatus according to claim 1, wherein said closure means associated with one of said outlet means includes a self-closing seal means adapted to be penetrated by the other end of said needle for permitting communication between said bag means and said vial means, said self-closing seal means being capable of automatically closing and sealing to prevent leakage therethrough when the needle is withdrawn therefrom so as to again close off said chamber.
3. An apparatus for transferring and mixing a liquid and a medicament, comprising: flexible bag means having a liquid holding chamber therein, and a liquid within said chamber substantially, but not entirely, filling said chamber so that some air space exists within said bag means; said bag means including first and second tubular portions fixedly secured thereto and projecting outwardly from one side thereof, said tubular portions communicating with said chamber for permitting liquid to be supplied to or removed therefrom; one of said tubular portions comprising an outlet spout adapted to be connected to an intravenous tube, and means associated with the free end of said outlet spout for normally maintaining same in a closed condition; said other tubular portion comprising an inlet spout, and closure means associated with said inlet spout adjacent the free end thereof for normally sealingly closing same, said closure means including a sealing member fixedly and sealingly engaged with said inlet spout adjacent the free end thereof and extending across the passageway defined within the interior of said spout for cLosing same, said sealing member being constructed of a resilient material permitting penetration thereof by a needle so as to allow communication with said chamber while the resilient material of said sealing member automatically expands to close and seal the aperture formed by the needle after the needle has been withdrawn from the sealing member; rigid vial means having a compartment therein which is at least partially filled with a medicament adapted to be mixed with a liquid, said vial means having a transfer needle mounted thereon and adapted for communication with said compartment, the needle being provided with a pointed end thereon remote from said compartment and being insertable through the sealing member on said inlet spout for providing communication between said compartment and said chamber; said vial means including a perforable resilient closure member at one end thereof for totally closing and sealing said compartment, said needle being pointed at the other end thereof, said other end being normally disposed adjacent said perforable closure member for penetrating same so as to permit said needle to communicate with said compartment, and means mounted on said vial means adjacent said one end thereof and disposed exteriorly of said perforable closure member for slidably supporting said needle while effectively preventing tilting of said needle so as to facilitate penetration of said perforable closure member by said other end of said needle; and said bag means being manually collapsible for pumping liquid between said vial means and said bag means through said inlet spout and said needle, the flow of liquid between said compartment and said chamber being caused by alternately compressing and releasing said bag means.
4. An apparatus according to claim 3, wherein said inlet and outlet spouts are disposed adjacent and in substantially parallel relationship to one another and extend outwardly from one end of said bag means, and said bag means being provided with means associated with the other end thereof for permitting said bag means to be suspended from a suitable holding device.
US3788369A 1971-06-02 1971-06-02 Apparatus for transferring liquid between a container and a flexible bag Expired - Lifetime US3788369A (en)

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US3987791A (en) * 1974-04-29 1976-10-26 Abbott Laboratories Additive transfer unit having a slidable piercing member
FR2378526A1 (en) * 1977-02-01 1978-08-25 Braun Melsungen Ag Cannula Levy and ventilation
US4125186A (en) * 1977-02-01 1978-11-14 Warner-Lambert Company Pharmaceutical delivery system
US4161178A (en) * 1977-12-08 1979-07-17 Abbott Laboratories Additive transfer device
US4169475A (en) * 1977-12-08 1979-10-02 Abbott Laboratories Additive transfer unit
US4191231A (en) * 1977-07-22 1980-03-04 Baxter Travenol Laboratories, Inc. Flexible collapsible containers, and method of molding
US4203443A (en) * 1977-12-08 1980-05-20 Abbott Laboratories Additive transfer unit with interlocking means
US4212373A (en) * 1977-09-21 1980-07-15 Scragg Edgar Peter Dosing a flowing fluid
US4259952A (en) * 1978-06-22 1981-04-07 Avoy Donald R Blood diluting method and apparatus
WO1981001241A1 (en) * 1979-11-05 1981-05-14 Baxter Travenol Lab System for the sterile mixing of materials
USRE31135E (en) * 1977-07-22 1983-02-01 Baxter Travenol Laboratories, Inc. Flexible collapsible containers, and method of molding
US4392851A (en) * 1981-11-23 1983-07-12 Abbott Laboratories In-line transfer unit
US4392850A (en) * 1981-11-23 1983-07-12 Abbott Laboratories In-line transfer unit
EP0091312A2 (en) * 1982-04-06 1983-10-12 Baxter Travenol Laboratories, Inc. Apparatus and method for mixing separately stored components
EP0091310A2 (en) * 1982-04-06 1983-10-12 Baxter Travenol Laboratories, Inc. A closed system and a method for mixing two separately stored components
WO1983003539A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Container for mixing a liquid and a solid
EP0102302A2 (en) * 1982-09-02 1984-03-07 Synthelabo Bag for medical use, especially for parenteral feeding
EP0107271A1 (en) * 1982-07-06 1984-05-02 E.I. Du Pont De Nemours And Company Sterile docking process, apparatus and system for thermoplastic resin tubes
US4467588A (en) * 1982-04-06 1984-08-28 Baxter Travenol Laboratories, Inc. Separated packaging and sterile processing for liquid-powder mixing
US4470812A (en) * 1983-02-28 1984-09-11 Martens Leslie V Cutting handpiece and coolant means
WO1985004801A1 (en) * 1984-04-16 1985-11-07 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US4567918A (en) * 1983-03-31 1986-02-04 Flexcel International, Inc. Liquid reservoir and method of dispensing a liquid therefrom by means of a vehicle
US4573993A (en) * 1983-09-29 1986-03-04 Instafil, Inc. Fluid transfer apparatus
US4607671A (en) * 1984-08-21 1986-08-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4610374A (en) * 1984-10-29 1986-09-09 Dougherty Brothers Company Apparatus for mixing flowable materials in sealed containers
EP0212100A1 (en) * 1985-06-25 1987-03-04 Laboratorien Hausmann AG Device with two solutions to be mixed together
US4676280A (en) * 1986-03-18 1987-06-30 Flexcel International, Inc. Liquid reservoir and method of using a vehicle to dispense liquid therefrom
US4712594A (en) * 1984-09-26 1987-12-15 Wesley Schneider Liquid storage and delivery system for protective mask
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US4941518A (en) * 1987-05-20 1990-07-17 Johnson & Johnson Medical, Inc. Fluid injection system
US5100394A (en) * 1988-01-25 1992-03-31 Baxter International Inc. Pre-slit injection site
US5122129A (en) * 1990-05-09 1992-06-16 Olson Donald J Sampler coupler device useful in the medical arts
US5304163A (en) * 1990-01-29 1994-04-19 Baxter International Inc. Integral reconstitution device
WO1995016490A1 (en) * 1993-12-16 1995-06-22 Baxter International Inc. In-line drug delivery device and method
US5526853A (en) * 1994-08-17 1996-06-18 Mcgaw, Inc. Pressure-activated medication transfer system
US5580349A (en) * 1993-09-17 1996-12-03 Avecor Cardiovascular, Inc. Blood reservoir
US5697409A (en) * 1996-02-21 1997-12-16 Biomerieux Vitek, Inc. Diluting and pipetting stations for sample testing machine
US5811142A (en) * 1996-04-03 1998-09-22 Tenneo Packaging Modified atmosphere package for cut of raw meat
US5928560A (en) * 1996-08-08 1999-07-27 Tenneco Packaging Inc. Oxygen scavenger accelerator
US6054153A (en) * 1998-04-03 2000-04-25 Tenneco Packaging Inc. Modified atmosphere package with accelerated reduction of oxygen level in meat compartment
US6321509B1 (en) 1999-06-11 2001-11-27 Pactiv Corporation Method and apparatus for inserting an oxygen scavenger into a modified atmosphere package
US6395195B1 (en) 1996-08-08 2002-05-28 Pactiv Corporation Oxygen scavenger accelerator
US20030036725A1 (en) * 2000-09-21 2003-02-20 Gilad Lavi Reconstitution and injection system
US20040082899A1 (en) * 1999-07-29 2004-04-29 Jean-Marie Mathias Biological fluid sampling apparatus
US20040199139A1 (en) * 1998-09-15 2004-10-07 Fowles Thomas A. Sliding reconstitution device for a diluent container
US20040241041A1 (en) * 1998-09-15 2004-12-02 Archie Woodworth Apparatus and method for fabricating a reconstitution assembly
US6852103B2 (en) 1997-12-04 2005-02-08 Baxter International Inc. Sliding reconstitution device with seal
US20050033260A1 (en) * 2003-07-17 2005-02-10 Tomohiko Kubo Transfer needle
US6890328B2 (en) 1998-09-15 2005-05-10 Baxter International Inc. Sliding reconstitution device for a diluent container
US20050133729A1 (en) * 2003-12-23 2005-06-23 Archie Woodworth Apparatus and method for fabricating a reconstitution assembly
US20050135965A1 (en) * 2003-12-23 2005-06-23 Williams John A. Method and apparatus for validation of sterilization process
US6926846B1 (en) 1996-08-08 2005-08-09 Pactiv Corporation Methods of using an oxygen scavenger
US20070073263A1 (en) * 2004-03-18 2007-03-29 Xianghua Liu Infusion bags having a medicine mixing nozzle with a puncture function
US20080065088A1 (en) * 2006-09-07 2008-03-13 Wyeth Bone Cement Mixing Systems and Related Methods
US20080219642A1 (en) * 2007-03-09 2008-09-11 Haitham Matloub Collapsible Fluid Containment Device With Semi-Rigid Support Members
US20090043282A1 (en) * 2005-04-29 2009-02-12 Wyeth Drug Delivery Devices and Related Components, Systems and Methods
CN104334467A (en) * 2012-06-08 2015-02-04 N·V·努特里奇亚 Flexible Container With Outlet

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Cited By (100)

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USRE29656E (en) * 1974-04-29 1978-06-06 Abbott Laboratories Additive transfer unit having a slidable piercing member
US3987791A (en) * 1974-04-29 1976-10-26 Abbott Laboratories Additive transfer unit having a slidable piercing member
FR2378526A1 (en) * 1977-02-01 1978-08-25 Braun Melsungen Ag Cannula Levy and ventilation
US4125186A (en) * 1977-02-01 1978-11-14 Warner-Lambert Company Pharmaceutical delivery system
USRE31135E (en) * 1977-07-22 1983-02-01 Baxter Travenol Laboratories, Inc. Flexible collapsible containers, and method of molding
US4191231A (en) * 1977-07-22 1980-03-04 Baxter Travenol Laboratories, Inc. Flexible collapsible containers, and method of molding
US4212373A (en) * 1977-09-21 1980-07-15 Scragg Edgar Peter Dosing a flowing fluid
US4169475A (en) * 1977-12-08 1979-10-02 Abbott Laboratories Additive transfer unit
US4203443A (en) * 1977-12-08 1980-05-20 Abbott Laboratories Additive transfer unit with interlocking means
US4161178A (en) * 1977-12-08 1979-07-17 Abbott Laboratories Additive transfer device
US4259952A (en) * 1978-06-22 1981-04-07 Avoy Donald R Blood diluting method and apparatus
WO1981001241A1 (en) * 1979-11-05 1981-05-14 Baxter Travenol Lab System for the sterile mixing of materials
EP0079327A2 (en) * 1979-11-05 1983-05-18 Baxter Travenol Laboratories, Inc. Fluid transfer assembly
EP0079327A3 (en) * 1979-11-05 1984-04-25 Baxter Travenol Laboratories, Inc. Fluid transfer assembly
US4392851A (en) * 1981-11-23 1983-07-12 Abbott Laboratories In-line transfer unit
US4392850A (en) * 1981-11-23 1983-07-12 Abbott Laboratories In-line transfer unit
US4467588A (en) * 1982-04-06 1984-08-28 Baxter Travenol Laboratories, Inc. Separated packaging and sterile processing for liquid-powder mixing
US4410321A (en) * 1982-04-06 1983-10-18 Baxter Travenol Laboratories, Inc. Closed drug delivery system
US4411662A (en) * 1982-04-06 1983-10-25 Baxter Travenol Laboratories, Inc. Sterile coupling
WO1983003540A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Sterile coupling
WO1983003586A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Closed drug delivery system
WO1983003539A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Container for mixing a liquid and a solid
US4432755A (en) * 1982-04-06 1984-02-21 Baxter Travenol Laboratories, Inc. Sterile coupling
EP0091310A2 (en) * 1982-04-06 1983-10-12 Baxter Travenol Laboratories, Inc. A closed system and a method for mixing two separately stored components
US4484920A (en) * 1982-04-06 1984-11-27 Baxter Travenol Laboratories, Inc. Container for mixing a liquid and a solid
EP0091310A3 (en) * 1982-04-06 1984-09-12 Baxter Travenol Laboratories, Inc. A closed system and a method for mixing two separately stored components
EP0091312A2 (en) * 1982-04-06 1983-10-12 Baxter Travenol Laboratories, Inc. Apparatus and method for mixing separately stored components
EP0091312A3 (en) * 1982-04-06 1984-09-12 Baxter Travenol Laboratories, Inc. Apparatus and method for mixing separately stored components
US4458733A (en) * 1982-04-06 1984-07-10 Baxter Travenol Laboratories, Inc. Mixing apparatus
EP0107271A1 (en) * 1982-07-06 1984-05-02 E.I. Du Pont De Nemours And Company Sterile docking process, apparatus and system for thermoplastic resin tubes
EP0102302A2 (en) * 1982-09-02 1984-03-07 Synthelabo Bag for medical use, especially for parenteral feeding
EP0102302A3 (en) * 1982-09-02 1984-04-04 Synthelabo Bag for medical use, especially for parenteral feeding
FR2532550A1 (en) * 1982-09-02 1984-03-09 Synthelabo Biomedical Pockets for medical purposes, in particular destinies in parenteral nutrition
US4559053A (en) * 1982-09-02 1985-12-17 Synthelabo Bags for medical use and intended in particular for parenteral nutrition
US4470812A (en) * 1983-02-28 1984-09-11 Martens Leslie V Cutting handpiece and coolant means
US4567918A (en) * 1983-03-31 1986-02-04 Flexcel International, Inc. Liquid reservoir and method of dispensing a liquid therefrom by means of a vehicle
US4573993A (en) * 1983-09-29 1986-03-04 Instafil, Inc. Fluid transfer apparatus
WO1985004801A1 (en) * 1984-04-16 1985-11-07 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US4607671A (en) * 1984-08-21 1986-08-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4759756A (en) * 1984-09-14 1988-07-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4712594A (en) * 1984-09-26 1987-12-15 Wesley Schneider Liquid storage and delivery system for protective mask
US4610374A (en) * 1984-10-29 1986-09-09 Dougherty Brothers Company Apparatus for mixing flowable materials in sealed containers
EP0212100A1 (en) * 1985-06-25 1987-03-04 Laboratorien Hausmann AG Device with two solutions to be mixed together
US4676280A (en) * 1986-03-18 1987-06-30 Flexcel International, Inc. Liquid reservoir and method of using a vehicle to dispense liquid therefrom
US4842028A (en) * 1987-05-13 1989-06-27 Baxter International Inc. Fluid transfer apparatus
US4941518A (en) * 1987-05-20 1990-07-17 Johnson & Johnson Medical, Inc. Fluid injection system
US4913196A (en) * 1987-05-20 1990-04-03 Surgikos, Inc. Fluid injection system pumping methods
US5100394A (en) * 1988-01-25 1992-03-31 Baxter International Inc. Pre-slit injection site
EP0330130A3 (en) * 1988-02-25 1991-06-05 Schiwa GmbH Infusion solution container
EP0330130A2 (en) * 1988-02-25 1989-08-30 Schiwa GmbH Infusion solution container
US4898209A (en) * 1988-09-27 1990-02-06 Baxter International Inc. Sliding reconstitution device with seal
US5304163A (en) * 1990-01-29 1994-04-19 Baxter International Inc. Integral reconstitution device
US5122129A (en) * 1990-05-09 1992-06-16 Olson Donald J Sampler coupler device useful in the medical arts
US5484406A (en) * 1992-11-19 1996-01-16 Baxter International Inc. In-line drug delivery device for use with a standard IV administration set and a method for delivery
US5580349A (en) * 1993-09-17 1996-12-03 Avecor Cardiovascular, Inc. Blood reservoir
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US6183790B1 (en) 1996-04-03 2001-02-06 Pactiv Corporation Modified atmosphere package
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US5948457A (en) * 1996-04-03 1999-09-07 Tenneco Packaging Inc. Modified atmosphere package
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US7147799B2 (en) 1996-08-08 2006-12-12 Pactiv Corporation Methods of using an oxygen scavenger
US6395195B1 (en) 1996-08-08 2002-05-28 Pactiv Corporation Oxygen scavenger accelerator
US6666988B2 (en) 1996-08-08 2003-12-23 Pactiv Corporation Methods of using an oxygen scavenger
US6852103B2 (en) 1997-12-04 2005-02-08 Baxter International Inc. Sliding reconstitution device with seal
US6054153A (en) * 1998-04-03 2000-04-25 Tenneco Packaging Inc. Modified atmosphere package with accelerated reduction of oxygen level in meat compartment
US6132781A (en) * 1998-04-03 2000-10-17 Pactiv Corporation Modified atmosphere package with accelerated reduction of oxygen level in meat compartment
US7425209B2 (en) 1998-09-15 2008-09-16 Baxter International Inc. Sliding reconstitution device for a diluent container
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US20080300570A1 (en) * 1998-09-15 2008-12-04 Baxter International Inc. Reconstitution assembly, locking device and method for a diluent container
US8226627B2 (en) 1998-09-15 2012-07-24 Baxter International Inc. Reconstitution assembly, locking device and method for a diluent container
US6890328B2 (en) 1998-09-15 2005-05-10 Baxter International Inc. Sliding reconstitution device for a diluent container
US20040241041A1 (en) * 1998-09-15 2004-12-02 Archie Woodworth Apparatus and method for fabricating a reconstitution assembly
US6494023B2 (en) 1999-06-11 2002-12-17 Pactiv Corporation Apparatus for inserting an oxygen scavenger into a modified atmosphere package
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US20080065088A1 (en) * 2006-09-07 2008-03-13 Wyeth Bone Cement Mixing Systems and Related Methods
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US20080219642A1 (en) * 2007-03-09 2008-09-11 Haitham Matloub Collapsible Fluid Containment Device With Semi-Rigid Support Members
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