EP0499764A1 - Device for the transfer of liquids between flexible containers and vials - Google Patents

Device for the transfer of liquids between flexible containers and vials Download PDF

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Publication number
EP0499764A1
EP0499764A1 EP19910500093 EP91500093A EP0499764A1 EP 0499764 A1 EP0499764 A1 EP 0499764A1 EP 19910500093 EP19910500093 EP 19910500093 EP 91500093 A EP91500093 A EP 91500093A EP 0499764 A1 EP0499764 A1 EP 0499764A1
Authority
EP
European Patent Office
Prior art keywords
canule
piece
vial
thickening
characterized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19910500093
Other languages
German (de)
French (fr)
Inventor
Francisco Faraco Munoz
Gregorio Frias Garcia
Miguel Angel Moreno De La Guerra
Carlos Manuel Sandoval Balcazar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST DE BIOLOG Y SUEROTERAPIA
INSTITUTO DE BIOLOGIA Y SUEROTERAPIA SA
Original Assignee
INSTITUTO DE BIOLOGIA Y SUEROTERAPIA, S.A.
INST DE BIOLOG Y SUEROTERAPIA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES9100538U priority Critical
Priority to ES9100538U priority patent/ES1016828Y/en
Application filed by INSTITUTO DE BIOLOGIA Y SUEROTERAPIA, S.A., INST DE BIOLOG Y SUEROTERAPIA filed Critical INSTITUTO DE BIOLOGIA Y SUEROTERAPIA, S.A.
Publication of EP0499764A1 publication Critical patent/EP0499764A1/en
Application status is Ceased legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089Containers or vials which are to be joined to each other in order to mix their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10Bag-type containers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/1475Inlet or outlet ports
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/2013Piercing means having two piercing ends

Abstract

A device is described for transferring liquids between flexible containers and vials, comprising a canule partially surrounded by a plastic piece and protruding laterally toward the inside of a thickening intended for engaging to a vial, sliding at the other end inside a piece which protects said protruding part of the needle and at its free end applied to a flexible container.

Description

  • The present invention, as stated in the title of this Specification, comprises a plastic device manufactured by injection, provided with a canule sharpened at both ends, adapted to be connected at one end to the appropriate access piece of a flexible container and, at the other end, to the top of a vial containing a liquid or powder which, by piercing of both containers with the canule, allows the transfer of liquids from the flexible container to the vial and from the latter to the flexible container, once its content is dissolved or diluted in the transferred solution, without the need to disconnect the initial connection at any moment of the process.
  • The device is characterized in being manufactured from such materials capable of being chemically or thermically sterilized, being apirogens and compatible with the solutions with which they are brought into contact.
  • The device can be manufactured with various shapes at the ends, in accordance with the kind of vial and flexible container to which it is going to be engaged. For example, as illustrative and in no way limitative, vials with a 13 mm, 22 mm or 32 mm diameter mouth, flexible containers with 50 ml, 100 ml, 250 ml, 500 ml, 1,000 ml, 21, 31 capacity with threaded coupling which can have different pitches or be engaged under pressure.
  • The essential feature of the device is that it is comprised of a stainless steel canule, firmly held to an injected plastic piece, bell-shaped at one end, with suitable dimensions for attaching to the vial mouth, and of another piece of injected plastic, in which the preceding piece internally slides and integral with the canule, so that in the most extended position the ends of the canule do not protrude beyond the ends of the device and, once slid, pierce the flexible container; this piece has at one end the shape of a chamber with appropriate design to be attached to the coupling of the flexible container.
  • An illustrative embodiment is next described in more detail and by no way limitative, of the object of the invention, making reference to the accompanying drawings, wherein:
    • Figures 1, 2 and 3 respectively represent an axial lengthwise section, a side and front views of the canule and of the injected plastic piece integral with it.
    • Figures 4, 5 and 6 respectively represent an axial lengthwise section, a side and front views of the injected plastic piece, inside which the piece integral with the canule slides.
    • Figure 7 represents an axial lengthwise section of the assemblied arrangement of the canule and the two injected pieces.
    • Figure 8 represents a side view of the arrangement in its most extended position, with the canule retracted and concealed.
    • Figure 9 represents a side view of the arrangement, engaged with the flexible container and with the piece integral with the canule, slid to its less extended position, to pierce the container with the canule.
  • As can particularly be seen in Figure 1, the canule 1 has the shape of a hollow cylinder, with both ends sharpened, and of a suitable length to be able to remain concealed until the time of use, which can be seen in Figure 7.
  • In the same Figure 1, it is seen that the injected piece is bell-shaped 2 at one end, with an inner diameter slightly larger than the outer diameter of the capsule of the vial with which it is engaged, and of a suitable length, so that on pressing the vial down to the bottom of the bell the canule pierces the cap of the vial and penetrates into the vial sufficiently to issue out of the interior of the cap.
  • To prevent ready release of the vial from the device, the bell has at one end some bulges 3 directed toward the inside to clamp the top of the vial; these bulges likewise hinder insertion of the top of the vial into the bell, whereby said bell has several openings 4, distributed symmetrically in order to facilitate insertion of the top of the vial.
  • Next to the bell it is seen that the injected piece clamps the canule, along most of its length, with a non-cylindrical section shape 5, whose purpose is to strengthen the canule, preventing it from folding on piercing and, thanks to its shape, engaging with the piece represented in Figures 4 and 6, allowing lengthwise sliding, but not the rotation of one piece with respect to the other. At the opposite end of the bell 2, the piece again has a cylindrical shape 6, of greater diameter than the non-cylindrical one 5, this increase having as its purpose to avoid separation of the two pieces once assembled; to facilitate mounting, this cylindrical zone is discontinued with hollow zones 7 by way of longitudinal grooves as can be seen in Figure 3.
  • As can be seen particularly in Figure 4, the injected piece, which will serve as guide and protection for the canule, has a zone of internal circular section shape 8, of appropriate length for concealing the canule in the most extended position of the device, as can be seen in Figure 8, and to produce the piercing of the flexible container in the most retracted position of the device, as can be seen in Figure 9; externally it has a grooved shape 9, in order to facilitate handling of the device, preventing slipping on being grasped with the fingers.
  • At one end the piece has internally modified its section, adopting a non-cylindrical section shape 10 like the non-cylindrical section zone 5, with a small clearance to facilitate lengthwise sliding of the pieces; this zone having the narrowing with respect to the circular section zone 8 allows, along with zone 6, avoidance of separation of the two pieces once assembled.
  • At the other end the piece comprises a chamber 11, which can have male screw fillets 12 of luer, luer lock, record type or any other suitable kind of screw pitch or shape for attaching to the supplementary coupling of the flexible container.
  • Once the cap of the vial is pierced with the canule 1, and the vial attached in the bell 2, the device is engaged to the flexible container by pressure screwing or equivalent action, in accordance with the kind of coupling 12 involved. This engagement is facilitated through the non-cylindrical section zones 5 and 10 which force the pieces and the canule to turn together. By pushing, exercised between the vial, or on the outer part of the bell 2, the piece joined to the canule slides internally to the piece engaged to the flexible container, until piercing said container, along the suitable lengths of this piece and of the canule.
  • Although one embodiment of the invention has been described and represented, it is evident that modifications can be introduced into it, comprised within the scope of same, and it should not be considered limited to said embodiment, but solely to the content of the following:

Claims (6)

  1. Device for the transfer of liquids between flexible containers and vials, characterized in that it is comprised by a stainless steel canule (1) joined to a plastic piece partially surrounding it and protruding on one side to the interior of a bell-shaped thickening adapted to engage to a vial, sliding at the other end, where the piece of a needle protrudes, inside a piece which protects said protruding part of the needle, and which is applied at its free end to a flexible container.
  2. Device according to claim 1, characterized in that the stainless steel canule (1) has both ends tapered and sharpened a suitable length so that, in the most extended position of the device, the canule (1) will not protrude therefrom and, in the most rectracted position, protrude from the protection piece, a sufficient length to pierce the flexible container.
  3. Device according to claim 1, characterized in that the bell-shaped thickening (2) of the plastic piece integral with the canule is of dimensions adapted to the top of the vial to which it is desired to transfer the liquid and is then provided with some bulges (3) directed inwardly, adjacent to the free edge of the bell, to avoid separation of the vial, and axial openings (4) beginning on said free edge, facilitating insertion of the top of the vial, and in that the outer area of said bell (2) surrounding integrally the canule (1) has a non-cylindrical smaller transversal cross-section (5), whose opposite end has a thickening to serve as stop to a corresponding thickening of the end of the protection piece and to avoid separation of the same, said thickening having a cylindrical profile (6) provided with wide grooves parallel to the axis of the canule (1), to facilitate engagement to the two plastic pieces.
  4. Device according to claim 1, characterized in that the protection piece of the canule (1), which also serves as guide for the piece integral with the canule, has a cylindrical transversal cross-section (8) bore with a diameter slightly larger than that of the broadened end of the canule piece, to allow lengthwise sliding of one piece with respect to the other, while the narrowing of the inner end of the same has a non-circular transversal cross-section, conjugated from the transversal section of the part surrounding the canule, with sufficient space to allow mutual sliding lengthwise, but not to turn, and likewise avoiding the separation of both pieces.
  5. Device according to claim 4, characterized in that the protection piece of the canule (1) has its outer surface grooved (9) in axial direction to improve manual attachment of the same.
  6. Device according to claim 4, characterized in that the outer or free end of the protection piece has a thickening provided inside with a screw or other type of suitable attachment to engage the device to the flexible container.
EP19910500093 1991-02-22 1991-08-08 Device for the transfer of liquids between flexible containers and vials Ceased EP0499764A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES9100538U 1991-02-22
ES9100538U ES1016828Y (en) 1991-02-22 1991-02-22 Device for the transfer of liquids between containers flexible and vials.

Publications (1)

Publication Number Publication Date
EP0499764A1 true EP0499764A1 (en) 1992-08-26

Family

ID=8271450

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910500093 Ceased EP0499764A1 (en) 1991-02-22 1991-08-08 Device for the transfer of liquids between flexible containers and vials

Country Status (3)

Country Link
EP (1) EP0499764A1 (en)
ES (1) ES1016828Y (en)
FI (1) FI912923A (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19644644C1 (en) * 1996-10-26 1997-12-04 Eltest Ges Fuer Elektrophorese Blood sample extraction device
WO1998002129A1 (en) * 1996-07-11 1998-01-22 Pharmacia & Upjohn Ab Method and device for sealing and connecting a container
FR2780878A1 (en) * 1998-07-10 2000-01-14 Frederic Senaux Clip-on cap e.g. for medication in powder form being transferred to solute pouch
WO2000028940A1 (en) * 1998-11-17 2000-05-25 Novo Nordisk A/S Medicament transferring device
WO2000028941A2 (en) * 1998-11-17 2000-05-25 Novo Nordisk A/S Transfer device
WO2000015292A3 (en) * 1998-09-15 2000-07-20 Baxter Int Sliding reconstitution device for a diluent container
WO2002053086A1 (en) * 2001-01-08 2002-07-11 Pierre Frezza Ampule for packaging and transferring a liquid or a powder for medical use
EP1060730A3 (en) * 1999-06-16 2002-10-30 Fresenius Kabi Deutschland GmbH Connection assembly including a coupling system and an access port
US6582415B1 (en) 1998-09-15 2003-06-24 Thomas A. Fowles Sliding reconstitution device for a diluent container
US6610040B1 (en) 1997-12-04 2003-08-26 Baxter International Inc. Sliding reconstitution device with seal
US8022375B2 (en) 2003-12-23 2011-09-20 Baxter International Inc. Method and apparatus for validation of sterilization
US8226627B2 (en) 1998-09-15 2012-07-24 Baxter International Inc. Reconstitution assembly, locking device and method for a diluent container
FR2998285A1 (en) * 2012-11-20 2014-05-23 Peugeot Citroen Automobiles Sa Device for filling a reservoir with a fluid and method of using the same
DE102006014495B4 (en) * 2006-03-29 2014-06-05 Sartorius Stedim Biotech Gmbh Apparatus for taking samples from flexible wall systems and for introducing fluids into them

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976073A (en) * 1974-05-01 1976-08-24 Baxter Laboratories, Inc. Vial and syringe connector assembly
EP0126718A2 (en) * 1983-05-20 1984-11-28 Bengt Gustavsson A device for transferring a substance from one vessel to another and further to the intended application
WO1986001712A1 (en) * 1984-09-14 1986-03-27 Baxter Travenol Laboratories, Inc. Reconstitution device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976073A (en) * 1974-05-01 1976-08-24 Baxter Laboratories, Inc. Vial and syringe connector assembly
EP0126718A2 (en) * 1983-05-20 1984-11-28 Bengt Gustavsson A device for transferring a substance from one vessel to another and further to the intended application
WO1986001712A1 (en) * 1984-09-14 1986-03-27 Baxter Travenol Laboratories, Inc. Reconstitution device

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002129A1 (en) * 1996-07-11 1998-01-22 Pharmacia & Upjohn Ab Method and device for sealing and connecting a container
DE19644644C1 (en) * 1996-10-26 1997-12-04 Eltest Ges Fuer Elektrophorese Blood sample extraction device
US6610040B1 (en) 1997-12-04 2003-08-26 Baxter International Inc. Sliding reconstitution device with seal
FR2780878A1 (en) * 1998-07-10 2000-01-14 Frederic Senaux Clip-on cap e.g. for medication in powder form being transferred to solute pouch
US8226627B2 (en) 1998-09-15 2012-07-24 Baxter International Inc. Reconstitution assembly, locking device and method for a diluent container
WO2000015292A3 (en) * 1998-09-15 2000-07-20 Baxter Int Sliding reconstitution device for a diluent container
US6582415B1 (en) 1998-09-15 2003-06-24 Thomas A. Fowles Sliding reconstitution device for a diluent container
US6755810B1 (en) 1998-11-17 2004-06-29 Novo Nordisk A/S Medicament transferring device
WO2000028940A1 (en) * 1998-11-17 2000-05-25 Novo Nordisk A/S Medicament transferring device
WO2000028941A3 (en) * 1998-11-17 2000-08-10 Novo Nordisk As Transfer device
WO2000028941A2 (en) * 1998-11-17 2000-05-25 Novo Nordisk A/S Transfer device
EP1060730A3 (en) * 1999-06-16 2002-10-30 Fresenius Kabi Deutschland GmbH Connection assembly including a coupling system and an access port
US6709424B1 (en) 1999-06-16 2004-03-23 Fre{overscore (s)}nius Kabi Deutschland GmbH Connector with a coupling system and a port system
WO2002053086A1 (en) * 2001-01-08 2002-07-11 Pierre Frezza Ampule for packaging and transferring a liquid or a powder for medical use
US7261707B2 (en) 2001-01-08 2007-08-28 Pierre Frezza Ampule for packaging and transferring a liquid or a powder for medical use
FR2819174A1 (en) * 2001-01-08 2002-07-12 Pierre Frezza Ampoule for packaging and transferring a liquid or a powder for medical use in a container
US8022375B2 (en) 2003-12-23 2011-09-20 Baxter International Inc. Method and apparatus for validation of sterilization
DE102006014495B4 (en) * 2006-03-29 2014-06-05 Sartorius Stedim Biotech Gmbh Apparatus for taking samples from flexible wall systems and for introducing fluids into them
FR2998285A1 (en) * 2012-11-20 2014-05-23 Peugeot Citroen Automobiles Sa Device for filling a reservoir with a fluid and method of using the same
WO2014079815A1 (en) * 2012-11-20 2014-05-30 Peugeot Citroen Automobiles Sa Device for filling a tank with a fluid and method for using said device

Also Published As

Publication number Publication date
FI912923A (en) 1992-08-23
ES1016828Y (en) 1992-06-01
ES1016828U (en) 1991-12-01
FI912923D0 (en)
FI912923A0 (en) 1991-06-17

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