UY37881A - Agentes de iarn y composiciones para inhibir la expresión de la angiopoyetina tipo 3 (angptl3) y métodos de uso - Google Patents

Agentes de iarn y composiciones para inhibir la expresión de la angiopoyetina tipo 3 (angptl3) y métodos de uso

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Publication number
UY37881A
UY37881A UY0001037881A UY37881A UY37881A UY 37881 A UY37881 A UY 37881A UY 0001037881 A UY0001037881 A UY 0001037881A UY 37881 A UY37881 A UY 37881A UY 37881 A UY37881 A UY 37881A
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UY
Uruguay
Prior art keywords
angptl3
agents
compositions
expression
methods
Prior art date
Application number
UY0001037881A
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English (en)
Inventor
Zhen Li
Rui Zhu
So Wong
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Arrowhead Pharmaceuticals Inc
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Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of UY37881A publication Critical patent/UY37881A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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Abstract

La presente divulgación se refiere a agentes de iARN, por ejemplo, agentes de iARN de cadena doble, capaces de inhibir la expresión del gen de la Angiopoyetina tipo 3 (también denominada ANGPTL3, ANGPL3, proteína angiopoyetina tipo 3), y composiciones que incluyen agentes de iARN de ANGPTL3. También se divulgan métodos para usar los agentes de iARN de ANGPTL3 y composiciones. Los agentes de iARN de ANGPTL3 divulgados en la presente pueden estar conjugados con ligandos de direccionamiento para facilitar la administración a células, inclusive a hepatocitos.
UY0001037881A 2017-09-14 2018-09-14 Agentes de iarn y composiciones para inhibir la expresión de la angiopoyetina tipo 3 (angptl3) y métodos de uso UY37881A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762558819P 2017-09-14 2017-09-14
US201762583919P 2017-11-09 2017-11-09
US201862651284P 2018-04-02 2018-04-02
US201862694976P 2018-07-07 2018-07-07

Publications (1)

Publication Number Publication Date
UY37881A true UY37881A (es) 2019-03-29

Family

ID=65630620

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UY0001037881A UY37881A (es) 2017-09-14 2018-09-14 Agentes de iarn y composiciones para inhibir la expresión de la angiopoyetina tipo 3 (angptl3) y métodos de uso

Country Status (22)

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US (2) US10995335B2 (es)
EP (1) EP3681513A4 (es)
JP (2) JP7281452B2 (es)
KR (1) KR20200044837A (es)
CN (2) CN111343994B (es)
AU (1) AU2018331383A1 (es)
BR (1) BR112020003126A2 (es)
CA (1) CA3074320A1 (es)
CL (1) CL2020000666A1 (es)
CO (1) CO2020001740A2 (es)
EC (1) ECSP20018305A (es)
IL (1) IL273173A (es)
JO (1) JOP20200050A1 (es)
MX (1) MX2020001912A (es)
PE (1) PE20201287A1 (es)
PH (1) PH12020500309A1 (es)
SG (1) SG11201912188RA (es)
TN (1) TN2020000038A1 (es)
TW (1) TWI823866B (es)
UY (1) UY37881A (es)
WO (1) WO2019055633A1 (es)
ZA (1) ZA202103669B (es)

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