PE20201287A1 - Agentes de iarn y composiciones para inhibir la expresion de la angiopoyetina tipo 3 (angptl3) y metodos de uso - Google Patents

Agentes de iarn y composiciones para inhibir la expresion de la angiopoyetina tipo 3 (angptl3) y metodos de uso

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Publication number
PE20201287A1
PE20201287A1 PE2020000671A PE2020000671A PE20201287A1 PE 20201287 A1 PE20201287 A1 PE 20201287A1 PE 2020000671 A PE2020000671 A PE 2020000671A PE 2020000671 A PE2020000671 A PE 2020000671A PE 20201287 A1 PE20201287 A1 PE 20201287A1
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Peru
Prior art keywords
angptl3
irna agents
compositions
methods
agents
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PE2020000671A
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English (en)
Inventor
Zhen Li
Rui Zhu
So Wong
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Arrowhead Pharmaceuticals Inc
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Publication of PE20201287A1 publication Critical patent/PE20201287A1/es

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Abstract

La presente divulgacion se refiere a agentes de iARN, por ejemplo, agentes de iARN de cadena doble, capaces de inhibir la expresion del gen de la Angiopoyetina tipo 3 (tambien denominada ANGPTL3, ANGPL3, proteina angiopoyetina tipo 3), y composiciones que incluyen agentes de iARN de ANGPTL3. Tambien se divulgan metodos para usar los agentes iARN de ANGPTL3 y composiciones. Los agentes iARN de ANGPTL3 divulgados en la presente pueden estar conjugados con ligandos de direccionamiento para facilitar la administracion a celulas, inclusive a hepatocitos. Tambien se describen composiciones farmaceuticas que incluyen uno o mas agentes de iARN de ANGPTL3, opcionalmente con uno o mas productos terapeuticos adicionales. La administracion de los agentes de iARN de ANGPTL3 in vivo proporciona la inhibicion de la expresion del gen ANGPTL3, y puede dar como resultado niveles de trigliceridos y/o niveles de colesterol reducidos en el sujeto. Los agentes de iARN se pueden usar en metodos de tratamiento de enfermedades y trastornos relacionados con ANGPTL3 que incluyen enfermedades cardiovasculares, tales como hipertrigliceridemia e hiperlipidemia
PE2020000671A 2017-09-14 2018-09-13 Agentes de iarn y composiciones para inhibir la expresion de la angiopoyetina tipo 3 (angptl3) y metodos de uso PE20201287A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762558819P 2017-09-14 2017-09-14
US201762583919P 2017-11-09 2017-11-09
US201862651284P 2018-04-02 2018-04-02
US201862694976P 2018-07-07 2018-07-07
PCT/US2018/050848 WO2019055633A1 (en) 2017-09-14 2018-09-13 RNAI AGENTS AND COMPOSITIONS FOR INHIBITING ANALOGUE EXPRESSION OF ANGIOPOIETIN 3 (ANGPTL3) AND METHODS OF USE

Publications (1)

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PE20201287A1 true PE20201287A1 (es) 2020-11-24

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PE2020000671A PE20201287A1 (es) 2017-09-14 2018-09-13 Agentes de iarn y composiciones para inhibir la expresion de la angiopoyetina tipo 3 (angptl3) y metodos de uso

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US (2) US10995335B2 (es)
EP (1) EP3681513A4 (es)
JP (2) JP7281452B2 (es)
KR (1) KR20200044837A (es)
CN (2) CN117701562A (es)
AU (1) AU2018331383A1 (es)
BR (1) BR112020003126A2 (es)
CA (1) CA3074320A1 (es)
CL (1) CL2020000666A1 (es)
CO (1) CO2020001740A2 (es)
EC (1) ECSP20018305A (es)
IL (1) IL273173A (es)
JO (1) JOP20200050A1 (es)
MX (1) MX2020001912A (es)
PE (1) PE20201287A1 (es)
PH (1) PH12020500309A1 (es)
SG (1) SG11201912188RA (es)
TN (1) TN2020000038A1 (es)
TW (1) TWI823866B (es)
UY (1) UY37881A (es)
WO (1) WO2019055633A1 (es)
ZA (1) ZA202103669B (es)

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