CO2020001740A2 - Agentes de iarn y composiciones para inhibir la expresión de la angiopoyetina tipo 3 (angptl3) y métodos de uso - Google Patents

Agentes de iarn y composiciones para inhibir la expresión de la angiopoyetina tipo 3 (angptl3) y métodos de uso

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Publication number
CO2020001740A2
CO2020001740A2 CONC2020/0001740A CO2020001740A CO2020001740A2 CO 2020001740 A2 CO2020001740 A2 CO 2020001740A2 CO 2020001740 A CO2020001740 A CO 2020001740A CO 2020001740 A2 CO2020001740 A2 CO 2020001740A2
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Colombia
Prior art keywords
angptl3
agents
compositions
irna agents
methods
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CONC2020/0001740A
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English (en)
Inventor
Zhen Li
Rui Zhu
So Wong
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Arrowhead Pharmaceuticals Inc
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Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of CO2020001740A2 publication Critical patent/CO2020001740A2/es

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Abstract

La presente divulgación se refiere a agentes de iARN, por ejemplo, agentes de iARN de cadena doble, capaces de inhibir la expresión del gen de la Angiopoyetina tipo 3 (también denominada ANGPTL3, ANGPL3, proteína angiopoyetina tipo 3), y composiciones que incluyen agentes de iARN de ANGPTL3. También se divulgan métodos para usar los agentes de iARN de ANGPTL3 y composiciones. Los agentes de iARN de ANGPTL3 divulgados en la presente pueden estar conjugados con ligandos de direccionamiento para facilitar la administración a células, inclusive a hepatocitos. También se describen composiciones farmacéuticas que incluyen uno o más agentes de iARN de ANGPTL3, opcionalmente con uno o más productos terapéuticos adicionales. La administración de los agentes de iARN de ANGPTL3 in vivo proporciona la inhibición de la expresión del gen ANGPTL3, y puede dar como resultado niveles de triglicéridos y/o niveles de colesterol reducidos en el sujeto. Los agentes de iARN se pueden usar en métodos de tratamiento de enfermedades y trastornos relacionados con ANGPTL3 que incluyen enfermedades cardiovasculares, tales como hipertrigliceridemia e hiperlipidemia
CONC2020/0001740A 2017-09-14 2020-02-14 Agentes de iarn y composiciones para inhibir la expresión de la angiopoyetina tipo 3 (angptl3) y métodos de uso CO2020001740A2 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762558819P 2017-09-14 2017-09-14
US201762583919P 2017-11-09 2017-11-09
US201862651284P 2018-04-02 2018-04-02
US201862694976P 2018-07-07 2018-07-07
PCT/US2018/050848 WO2019055633A1 (en) 2017-09-14 2018-09-13 RNAI AGENTS AND COMPOSITIONS FOR INHIBITING ANALOGUE EXPRESSION OF ANGIOPOIETIN 3 (ANGPTL3) AND METHODS OF USE

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CO2020001740A2 true CO2020001740A2 (es) 2020-05-29

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US (2) US10995335B2 (es)
EP (1) EP3681513A4 (es)
JP (2) JP7281452B2 (es)
KR (1) KR20200044837A (es)
CN (2) CN111343994B (es)
AU (1) AU2018331383A1 (es)
BR (1) BR112020003126A2 (es)
CA (1) CA3074320A1 (es)
CL (1) CL2020000666A1 (es)
CO (1) CO2020001740A2 (es)
EC (1) ECSP20018305A (es)
IL (1) IL273173A (es)
JO (1) JOP20200050A1 (es)
MX (1) MX2020001912A (es)
PE (1) PE20201287A1 (es)
PH (1) PH12020500309A1 (es)
SG (1) SG11201912188RA (es)
TN (1) TN2020000038A1 (es)
TW (1) TWI823866B (es)
UY (1) UY37881A (es)
WO (1) WO2019055633A1 (es)
ZA (1) ZA202103669B (es)

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