UY37871A - Agentes de iarn y composiciones para inhibir la expresión de la apolipoproteína c-iii (apoc3) - Google Patents

Agentes de iarn y composiciones para inhibir la expresión de la apolipoproteína c-iii (apoc3)

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Publication number
UY37871A
UY37871A UY0001037871A UY37871A UY37871A UY 37871 A UY37871 A UY 37871A UY 0001037871 A UY0001037871 A UY 0001037871A UY 37871 A UY37871 A UY 37871A UY 37871 A UY37871 A UY 37871A
Authority
UY
Uruguay
Prior art keywords
iii
apoc3
agents
apolipoprotein
expression
Prior art date
Application number
UY0001037871A
Other languages
English (en)
Inventor
Steven Kanner
Tao Pei
Zhen Li
Rui Zhu
So Wong
Original Assignee
Arrowhead Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of UY37871A publication Critical patent/UY37871A/es

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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C12N2310/351—Conjugate

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Abstract

La presente descripción se refiere a agentes de iARN, por ejemplo, agentes de iARN de cadena doble, capaces de inhibir la expresión del gen de la Apolipoproteína C-III (también denominada APOC3, apoC-III, APOC-III, y APO C-III), y composiciones que incluyen agentes de iARN de APOC3. Los agentes de iARN de APOC3 descritos en la presente pueden estar conjugados con ligandos diana, que incluyen ligandos que incluyen N-acetil-galactosamina, para facilitar la administración a células, que incluyen a hepatocitos
UY0001037871A 2017-09-11 2018-09-11 Agentes de iarn y composiciones para inhibir la expresión de la apolipoproteína c-iii (apoc3) UY37871A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762556818P 2017-09-11 2017-09-11
US201862643927P 2018-03-16 2018-03-16
US201862720434P 2018-08-21 2018-08-21

Publications (1)

Publication Number Publication Date
UY37871A true UY37871A (es) 2019-03-29

Family

ID=65630632

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UY0001037871A UY37871A (es) 2017-09-11 2018-09-11 Agentes de iarn y composiciones para inhibir la expresión de la apolipoproteína c-iii (apoc3)

Country Status (22)

Country Link
US (4) US10597657B2 (es)
EP (1) EP3681516A4 (es)
JP (2) JP7438103B2 (es)
KR (1) KR20200044013A (es)
AU (1) AU2018329190A1 (es)
BR (1) BR112020002413A2 (es)
CA (1) CA3074303A1 (es)
CL (1) CL2020000593A1 (es)
CO (1) CO2020002586A2 (es)
CR (1) CR20200108A (es)
EC (1) ECSP20017905A (es)
IL (1) IL273172A (es)
JO (1) JOP20200054A1 (es)
MX (1) MX2020002648A (es)
PE (1) PE20201283A1 (es)
PH (1) PH12020500332A1 (es)
SG (1) SG11201912178VA (es)
TN (1) TN2020000039A1 (es)
TW (2) TWI811238B (es)
UY (1) UY37871A (es)
WO (1) WO2019051402A1 (es)
ZA (1) ZA202100806B (es)

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TN2020000039A1 (en) * 2017-09-11 2021-10-04 Arrowhead Pharmaceuticals Inc Rnai agents and compositions for inhibiting expression of apolipoprotein c-iii (apoc3)

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